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| Product | Description | |
|---|---|---|
| LUF 5834 | LUF5834 is an A2A and A2B adenosine receptor agonist with an EC50 value of 12 nM. Synonyms: LUF5834; LUF-5834; LUF 5834; 2-Amino-4-(4-hydroxyphenyl)-6-[(1H-imidazol-2-ylmethyl)thio]-3,5-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 333962-91-7. Molecular formula: C17H12N6OS. Mole weight: 348.38. |  |
| LUF 6000 | LUF6000 is an allosteric modulator of the human A3 adenosine receptor (AR). It was found to be an allosteric enhancer of Emax. It exerted an Emax-enhancing effect at a concentration of 0.1 microM or higher. It was shown to increase the Emax of Cl-IB-MECA and other low-efficacy agonists to a larger extent than that of the high-efficacy agonist NECA. It converted a nucleoside A3 AR antagonist MRS542. It has anti-inflammatory effect. Uses: Luf6000 has anti-inflammatory effect. Synonyms: LUF6000; LUF 6000; LUF-6000. N-(3,4-Dichlorophenyl)-2-cyclohexyl-1H-imidazo[4,5-c]quinolin-4-amine;2-Cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo[4,5-c]quinolin-4-amine. Grades: >98 %. CAS No. 890087-21-5. Molecular formula: C22H20Cl2N4. Mole weight: 411.33. | |
| Luffariellolide | Luffariellolide is a natural sesterterpenoid isolated from the Palauan spongeLuffariella sp. It reversibly inhibits phospholipase A2, displaying anti-inflammatory activity. It also acts as an agonist for the RA receptors RAR α, β, and γ but not for other nuclear receptors. Synonyms: 3-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohexen-1-yl)deca-3,7-dienyl]-2-hydroxy-2H-furan-5-one. Grades: ≥98%. CAS No. 111149-87-2. Molecular formula: C25H38O3. Mole weight: 386.6. | |
| Luotonin A | Luotonin A is an alkaloid isolated from a Chinese traditional herbal medicine Peganum nigellastrum. It binds to and stabilizes the topoisomerase I-DNA binary complex, leading to DNA breakage and cell death (IC50 = 5.07 - 12.6 μM). Synonyms: Quino[2',3':3,4]pyrrolo[2,1-b]quinazolin-11(13H)-one. Grades: ≥98%. CAS No. 205989-12-4. Molecular formula: C18H11N3O. Mole weight: 285.3. | |
| Lusaperidone | Lusaperidone, also known as R107474, is an α2 adrenergic receptor antagonist. R107474 showed high affinity for ha2A-, ha2B-, and ha2C-adrenoceptors, stably expressed in CHO cells. The compound bound preferentially to the ha2A- and ha2C-adrenoceptor subtypes (Ki = 0.13 and 0.15 nM, respectively) and was seven times less potent in binding to the ha2B-adrenoceptors (Ki = 1.03 nM). Synonyms: 3-[2-(3,4-dihydro-1H-[1]benzofuro[3,2-c]pyridin-2-yl)ethyl]-2-methylpyrido[1,2-a]pyrimidin-4-one; R107474; R 107474; R-107474. CAS No. 214548-46-6. Molecular formula: C22H21N3O2. Mole weight: 359.42. | |
| Luzindole | Luzindole is a melatonin receptor antagonist which preferentially targets MT1B. Synonyms: Luzindole, N-0774, N0774, N 0774, N-acetyl-2-benzyltryptamine. Grades: ≥99% by HPLC. CAS No. 117946-91-5. Molecular formula: C19H20N2O. Mole weight: 292.38. | |
| LW479 | LW479 is a HDAC inhibitor with marked cytotoxicity leading to apoptosis and cell cycle arrest in a panel of breast cancer cell lines. LW479 silences EGFR expression in breast cancer cells via inhibiting Sp1 and HDAC1 binding to EGFR promoter, and blocks EGF/EGFR signaling pathway and EGF-stimulated motility. Uses: Anticancer agent for breast cancer. Synonyms: LW479; LW 479; LW-479; 6-[2-[2-(3-Bromophenyl)-4-oxo-3-thiazolidinyl]phenoxy]-N-hydroxy-hexanamide. Grades: 98%. CAS No. 1688677-89-5. Molecular formula: C21H23BrN2O4S. Mole weight: 479.39. | |
| LX-1031 | LX-1031 is a heterocyclic substituted phenylalanine analog, an oral small molecule tryptophan hydroxylase (TPH) inhibitor that reduces synthesis of serotonin (5-HT) peripherally. It is being developed for conditions characterized by excess 5-HT expression such as diarrhea-predominant irritable bowel syndrome (IBS-D) and, possibly, carcinoid diarrhea. Synonyms: LX-1031; LX 1031; LX1031. Grades: >98%. CAS No. 945976-76-1. Molecular formula: C28H25F3N4O4. Mole weight: 538.52. | |
| LX2343 | LX2343 is an inhibitor of β-site amyloid protein cleaving enzyme 1 (BACE1/β-secretase) with IC50 = 11.43 μM. It also acts as a non-ATP competitive PI3K inhibitor (IC50 = 15.99 μM). LX2343 was shown to ameliorate the cognitive dysfunction of AD model rats by inhibiting oxidative stress-induced neuronal apoptosis and tauopathy. Synonyms: LX-2343; LX 2343; 2-[N-(Benzenesulfonyl)-5-chloro-2-methoxyanilino]-N-(1,3-benzodioxol-5-yl)acetamide. Grades: ≥98%. CAS No. 333745-53-2. Molecular formula: C22H19ClN2O6S. Mole weight: 474.91. | |
| LX-2761 | LX-2761 is a locally acting SGLT1 inhibitor that can delay intestinal glucose absorption in the body to improve blood sugar control. Synonyms: LX2761. Grades: ≥ 98 % by HPLC. CAS No. 1610954-97-6. Molecular formula: C32H47N3O6S. Mole weight: 601.8. | |
| LXH254 | LXH254 is a pan-Raf inhibitor developed for the treatment of solid tumors. Uses: Antineoplastic agents. Synonyms: LXH-254; LXH 254; N-[3-[2-(2-Hydroxyethoxy)-6-morpholin-4-ylpyridin-4-yl]-4-methylphenyl]-2-(trifluoromethyl)pyridine-4-carboxamide. Grades: ≥98%. CAS No. 1800398-38-2. Molecular formula: C25H25F3N4O4. Mole weight: 502.49. | |
| LXR623 | WAY-252623 (LXR-623) is a highly selective and orally bioavailable synthetic modulator of LXR, which can reduces total serum cholesterol and LDL cholesterol and inhibits lesion growth in models of atherosclerosis. IC50 values= 24 and 179 nM (for LXRβ and LXRα, respectively). Uses: A novel and potent lxr (liverx receptor) β-agonist used as a potential candidate for the treatment of atopic dermatitis ic50 values= 24 and 179 nm (for lxrβ and lxrα, respectively). Synonyms: 2-[(2-chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)indazole; 2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole; LXR 623; LXR-623; LXR623; WAY 252623; WAY-252623; WAY252623. Grades: ≥ 98.0%. CAS No. 875787-07-8. Molecular formula: C21H12ClF5N2. Mole weight: 422.78. | |
| LXS196 | LXS196 is a potent and orally active protein kinase C (PKC) inhibitor under clinical trials for the treatment of uveal melanoma, the most common cancer of the eye in adults. Synonyms: 3-amino-N-[3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl]-6-[3-(trifluoromethyl)pyridin-2-yl]pyrazine-2-carboxamide; LXS 196; LXS-196. CAS No. 1874276-76-2. Molecular formula: C22H23F3N8O. Mole weight: 472.47. | |
| LY 106737 | LY 106737 is phenylpiperidine opioid receptor antagonist, but no detailed information has been published yet. Synonyms: LY 106737; LY-106737; LY106737; cis-(+-)-3-(3,4-dimethyl-1-(2-phenylethyl)-4-piperidinyl)-Phenol. Grades: 98%. CAS No. 82970-72-7. Molecular formula: C21-H27-N-O. Mole weight: 309.45. | |
| LY 123502 | LY 123502 is an opioid agonist, but no detailed information has been published yet. Synonyms: LY 123502; LY-123502; LY123502; L-Tyrosyl-D-alanylglycyl-4-fluoro-L-phenylalanyl-L-2-phenylglycinamide monoacetate (salt). Grades: 98%. CAS No. 79561-42-5. Molecular formula: C33H39FN6O8. Mole weight: 666.70. | |
| LY 125180 | LY 125180 is a serotonin antagonist.It can effect on serotonin uptake and serotonin synthesis in rat brain in vitro and in vivo. Synonyms: LY 125180; LY-125180; LY125180. N,N-dimethyl-alpha-(2-(4-methylphenoxy)ethyl)-Benzenemethanamine hydrochloride. Grades: 98%. CAS No. 74515-39-2. Molecular formula: C18H24ClNO. Mole weight: 305.85. | |
| LY-150310 | LY-150310 is a histamine H1-receptor antagonist. It could alter prostanoid concentrations in vitro and in vivo. Uses: Ly-150310 could alter prostanoid concentrations. Synonyms: LY 150310; LY-150310; LY150310; 1H-Imidazole, 1-(1,2,3,4-tetrahydro-1-naphthalenyl)-;LY150310;1-(1,2,3,4-tetrahydronaphthalen-1-yl)imidazole. Grades: >98 %. CAS No. 103294-47-9. Molecular formula: C13H14N2. Mole weight: 198.27. | |
| LY 156735 | This active molecular is high affinity nonselective melatonin receptors MT1 and MT2 agonist which is under development for the treatment of insomnia and other sleep disorders. Its agonist action on MT1 and MT2 receptors in the suprachiasmatic nucleus in the brain enables its action as a chronobiotic. The action of LY 156735 on MT1 and MT2 receptors promots sleeping because melatonin's effects at these same receptors is linked with maintenance of normal-sleep wake cycle. The EC50 value of LY 156735 is 0.0479nM, compared to 0.063nM for melatonin. In May 2004, LY 156735 had received orphan drug status for the treatment of circadian sleep disorders in totally blind individuals in the US. In Nov 2005, data which was presented at the 18th Annual Congress of the European College of Neuropsychopharmacology had been added to the adverse events and Anxiety disorders therapeutic trials sections. Uses: The treatment of insomnia and other sleep disorders. Synonyms: LY 156735; LY156735; LY-156735; TIK-301; TIK 301; TIK301; N-[(2R)-2-(6-chloro-5-methoxy-1H-indol-3-yl)propyl]acetamide. Grades: 98%. CAS No. 118702-11-7. Molecular formula: C14H17ClN2O2. Mole weight: 280.75. | |
| LY171883 | LY171883 is an orally available leukotriene D4 receptor antagonist. Uses: Leukotriene antagonists. Synonyms: LY-171883; LY 171883; Tomelukast; 1-[2-hydroxy-3-propyl-4-[4-(2H-tetrazol-5-yl)butoxy]phenyl]ethanone. Grades: ≥98%. CAS No. 88107-10-2. Molecular formula: C16H22N4O3. Mole weight: 318.4. | |
| LY 173013 | LY173013 is an antibacterial agent with bicyclic pyrazolidinones containing a novel aza-γ-lactam ring structure. The properties of this compound appear to be related to those of β-lactam antibiotics, because both classes of compounds have common binding molecules such as β-lactamases and penicillin-binding proteins. Uses: Antibacterial agent. Synonyms: LY 173013; LY-173013; LY173013. 2-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-6-methoxycarbonyl-3-oxo-2,7-dihydro-1H-pyrazolo[1,2-a]pyrazole-5-carboxylic acid. Grades: 98%. CAS No. 126165-78-4. Molecular formula: C15H16N6O7S. Mole weight: 424.39. | |
| LY-178002 | LY-178002 is a phospholipase A2 inhibitor. It also inhibits leukotriene B4 production. Synonyms: LY 178002; LY178002; LY-178002. 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one;5-(3,5-Bis(tert-butyl)-4-hydroxyphenyl)methylene-4-thiazolidinone;4-Thiazolidinone, 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-. Grades: >98%. CAS No. 107889-32-7. Molecular formula: C18H25NO2S. Mole weight: 319.46. | |
| LY 186826 | LY 186826 is an antibacterial agent with bicyclic pyrazolidinones containing a novel aza-γ-lactam ring structure. The properties of this compound appear to be related to those of β-lactam antibiotics, because both classes of compounds have common binding molecules such as β-lactamases and penicillin-binding proteins. Uses: Antibacterial agent. Synonyms: LY 186826; LY186826; LY-186826. AC1NUT6W; CHEMBL436143; HE187334; 6-acetyl-2-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-oxo-2,7-dihydro-1H-pyrazolo[1,2-a]pyrazole-5-carboxylic acid. Grades: 98%. CAS No. 126165-79-5. Molecular formula: C15H16N6O6S. Mole weight: 408.39. | |
| LY-190388 | LY-190388 is an μ receptor agonist. It is a penicillamine-containing enkephalin analog and has analgesia effect. Uses: Ly-190388 has analgesia effect. Synonyms: LY 190388; LY190388; LY-190388; H-Tyr-pen-gly-phe-val-OH;Tyr-penicillamine-gly-phe-val;(2R)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-[2-[[(2S)-2-amino-3-methyl-3-sulfanylbutanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoic acid;LY190388;D-Valine, N-(N-(N-(3-mercapto-N-L-tyrosyl-D-valyl)glycyl)-L-phenylalanyl)-. Grades: >98%. CAS No. 105496-35-3. Molecular formula: C30H41N5O7S. Mole weight: 615.74. | |
| LY 203647 | LY 203647 is a a leukotriene D4 and E4 receptor antagonist with a tetrazole nucleus structure originated by Eli Lilly. No development for treatment of Ischaemic heart disorders by LY 203647 has been reported yet. Uses: Ischaemic heart disorders. Synonyms: LY 203647; LY203647; LY-203647; 1-(2-hydroxy-3-propyl-4-(4-(2-(4-(1H-tetrazol-5-yl)butyl)-2H-tetrazol-5-yl)butoxy)phenyl)-Ethanone. Grades: 98%. CAS No. 122009-61-4. Molecular formula: C21H30N8O3. Mole weight: 442.52. | |
| LY 206130 | This active molecular is a serotonin 5-HT1A antagonist. LY 206130 (3.0 mg/kg, s.c.) alone significantly increased norepinephrine level by 60%, dopamine levels by 34% without affecting 5-HT levels. Synonyms: LY 206130; LY-206130; LY206130. CHEMBL396185;AC1L3YFA; SCHEMBL7287084;1-(cyclohexylamino)-3-(1H-indol-4-yloxy)propan-2-ol. Grades: 98%. CAS No. 127414-58-8. Molecular formula: C17H24N2O2. Mole weight: 288.39. | |
| LY 2087101 | LY 2087101 is a selective positive allosteric potentiator of α7 and α4β2 nicotinic acetylcholine receptors. Synonyms: LY2087101; LY 2087101; LY-2087101; [2-[(4-Fluorophenyl)amino]-4-methyl-5-thiazolyl]-3-thienylmethanone. Grades: ≥98% by HPLC. CAS No. 913186-74-0. Molecular formula: C15H11FN2OS2. Mole weight: 318.39. | |
| LY 210073 | LY 210073, an oxoxanthene derivative, has been found to be a LTB4 receptor antagonist that could probably be effective against inflammation and rheumatic disorders. Synonyms: 9H-Xanthene-4-propanoicacid, 7-carboxy-3-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-9-oxo-; ACMC-20n5ed; CTK0H7653; CTK8H0111; LY 210073; LY-210073; LY210073. Grades: 98%. CAS No. 148291-65-0. Molecular formula: C30H28O8. Mole weight: 516.55. | |
| LY 213024 | LY 213024 is a potent leukotriene B4 receptor antagonist. Agents which block the production of the leukotrienes have shown reduction of infarct size in animal models of myocardial infarction. Uses: Myocardial infarction. Synonyms: LY 213024; LY213024; LY-213024; 3-[3-(2-carboxyethyl)-4-decoxybenzoyl]benzoic acid. Grades: 98%. CAS No. 117423-95-7. Molecular formula: C27H34O6. Mole weight: 454.56. | |
| LY 215840 | LY 215840 is a potent antagonist of both Serotonin 2A receptor and Serotonin 7 receptor. It can reduce stimulatory effect of serotonin on aldosterone secretion and 5-HT-induced cAMP formation. LY 215840 has anti-hypertensive and muscle relaxant effects in animal models. No development was reported for the treatment of Thrombosis and Migraine. Uses: Migraine; thrombosis. Synonyms: LY 215840; LY-215840; LY215840. (6aR,9R)-N-[(1S,2R)-2-hydroxycyclopentyl]-7-methyl-4-propan-2-yl-6,6a,8,9,10,10a-hexahydroindolo[4,3-fg]quinoline-9-carboxamide. Grades: >98 %. CAS No. 137328-52-0. Molecular formula: C24H33N3O2. Mole weight: 395.55. | |
| LY 215890 | LY 215890 has been found to have probable antibiotic activity. Synonyms: LY 215890; LY-215890; LY215890. 7-(((2-Amino-4-thiazolyl)hydroximinoacetyl)amino)-3-chloro-1-carba-1-dethia-3-cephem-4-carboxylic acid. Grades: 98%. CAS No. 153502-35-3. Molecular formula: C13H12ClN5O5S. Mole weight: 385.78. | |
| LY2183240 | LY2183240 is a novel and highly potent blocker of anandamide uptake. It inhibits fatty acid amide hydrolase (FAAH) activity. It increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain. Synonyms: LY2183240; LY-2183240; LY 2183240. Grades: >98%. CAS No. 874902-19-9. Molecular formula: C17H17N5O. Mole weight: 307.35. | |
| LY 219057 | LY 219057, a phenylpyrazolidine derivative, has been found to be a CCK receptor antagonist that could probably be useful in gastrointestinal disorder studies. Synonyms: LY 219057; LY-219057; CHEMBL353189; N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxo-4,5-diphenylpyrazolidine-1-carbothioamide. Grades: 98%. CAS No. 150351-93-2. Molecular formula: C23H17ClF3N3OS. Mole weight: 475.91. | |
| LY 221068 | LY 221068 is a Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties. But no development was reported for Rheumatic disorders in USA. Uses: Rheumatic disorders. Synonyms: LY 221068; LY-221068; LY221068; 5-((3,5-Bis(1,1,-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(dimethylamino)-4-thiazolidinone. Grades: 98%. CAS No. 132392-39-3. Molecular formula: C20H30N2O2S. Mole weight: 362.54. | |
| LY-221501 | LY-221501, a piperidine derivative, has been found to be a NMDA receptor antagonist. Synonyms: LY 221501; LY221501; LY-221501; Cis-4-(3-Carboxyprop-1-yl)piperidine-2-carboxylic acid; 145512-35-2; LY 221501; 4-Piperidinebutanoicacid, 2-carboxy-, (2R,4S)-; AC1L31HC. Grades: 98%. CAS No. 145512-35-2. Molecular formula: C10H17NO4. Mole weight: 215.25. | |
| LY223982 | This active molecular is benzophenone dicarboxylic acid derivative which is a potent BLT1 receptor antagonist. It inhibits the binding of radiolabeled-LTB4 to isolated human neutrophils and IC50 value is 13.2 nM. LY223982 also inhibits the leukotriene B4 (LTB4)-induced aggregation of guinea human neutrophils. IC50 value is 100 nM. In Aug 1997, phase II for Psoriasis in USA was discontinued. Uses: Psoriasis. Synonyms: LY 223982; LY-223982; LY223982; CGS 23131; SKF 107324; CGS23131; SKF107324; CGS-23131; SKF-107324; 5-(3-Carboxybenzoyl)-2-((6-(4-methoxyphenyl)-5-hexenyl)oxy)benzenepropanoic acid. Grades: 98%. CAS No. 117423-74-2. Molecular formula: C30H30O7. Mole weight: 502.56. | |
| LY 225910 | LY 225910 is a CCK2 receptor antagonist with IC50 value of 9.3 nM. Synonyms: LY 225910; LY-225910; LY225910; 2-[2-(5-Bromo-1H-indol-3-yl)ethyl]-3-[3-(1-methylethoxy)phenyl]-4-(3H)-quinazoline. Grades: ≥95%. CAS No. 133040-77-4. Molecular formula: C27H24BrN3O2. Mole weight: 502.41. | |
| LY 233053 | LY 233053 is an NMDA receptor antagonist with IC50 value of 7 nM. Synonyms: LY233053; LY-233053 LY 233053; (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid. Grades: ≥99% by HPLC. CAS No. 125546-04-5. Molecular formula: C8H13N5O2. Mole weight: 211.22. | |
| LY2334737 | LY2334737 is an orally available valproic acid ester of gemcitabine, which is a broad-spectrum antimetabolite with antineoplastic activity. It is an orally available prodrug of gemcitabine which is a nucleoside analog used as chemotherapy. It is hydrolyzed by carboxylesterase 2 (CES2) and releases gemcitabine systemically over a period of time consistent with formation rate-limited kinetics. It was less cytotoxic to a SK-OV-3 CES2 knockdown than parental cells. Uses: Ly2334737 is used as chemotherapy. it has antineoplastic activity. Synonyms: LY2334737; LY 2334737; LY-2334737; gemcitabine prodrug; 2'-Deoxy-2',2'-difluoro-N-(1-oxo-2-propylpentyl)cytidine;N-[1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-propylpentanamide. Grades: >98 %. CAS No. 892128-60-8. Molecular formula: C17H25F2N3O5. Mole weight: 389.39. | |
| LY 233536 | LY 233536 is a novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, but few detailed information has been published yet. Synonyms: LY 233536; LY-233536; LY233536; (3R-(3alpha,4aalpha,6beta,8aalpha))-decahydro-6-(1H-tetrazol-5-ylmethyl)- 3-Isoquinolinecarboxylic acid. Grades: 98%. CAS No. 136845-59-5. Molecular formula: C12H19N5O2. Mole weight: 265.32. | |
| LY 235959 | LY 235959 is a competitive N-Methyl-D-Aspartate Receptor antagonist originated by Eli Lilly. No development was reported for treatment of Movement disorders in USA. Research for treatment of Alzheimer's disease was discontinued. Uses: Alzheimer's disease;movement disorders. Synonyms: LY 235959; LY235959; LY-235959; (3S)-(3-alpha-4-alpha,alpha-6-beta-8-alpha,alpha)-Decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid;LY 235959. Grades: 98%. CAS No. 137433-06-8. Molecular formula: C11H20NO5P. Mole weight: 277.26. | |
| LY 2389575 hydrochloride | LY 2389575 hydrochloride is a mGluR3 receptor antagonist with IC50 value of 190 nM. Synonyms: LY2389575; LY-2389575; LY 2389575; (3S)-N-(2,4-Dichlorobenzyl)-1-(5-bromopyrimidin-2-yl)pyrrolidinyl-3-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 885104-09-6. Molecular formula: C15H15BrCl2N4.HCl. Mole weight: 438.58. | |
| LY2409881 | LY2409881 is a novel selective inhibitor of IKK2. It inhibited constitutively activated NF-κB, and caused concentration- and time-dependent growth inhibition and apoptosis in lymphoma cells. It suppressed the activity of the NF-κB subunit p65 in lymphoma cells treated by the HDAC inhibitor romidepsin, underlying a potential mechanism of the marked synergy observed of these two drugs. Synonyms: LY2409881; LY 2409881; LY-2409881. Grades: >98%. CAS No. 946518-61-2. Molecular formula: C24H29ClN6OS. Mole weight: 485.04. | |
| LY2409881 Trihydrochloride | LY2409881 is a potent and selective IKK2 inhibitor with IC50 of 30 nM, >10-fold selectivity over IKK1 and other common kinases. Synonyms: LY2409881; LY 2409881; LY-2409881. Grades: >98%. CAS No. 946518-60-1. Molecular formula: C24H32Cl4N6OS. Mole weight: 594.43. | |
| LY 245769 | LY 245769 is a leukotriene E4 (LTE4) inhibitor, and it can inhibit the oxidative degradation of LTE4 and N-acetyl-LTE4 in animal model. LY 245769, as one of the omega-trifluoro analogs of leukotrienes, will provide a new tool for interfering with the inactivation of leukotrienes in the omega-oxidation pathway. Synonyms: LY 245769; LY-245769; LY245769; R-(R*,S*-(E,Z)))-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-. Grades: 98%. CAS No. 127345-02-2. Molecular formula: C25H33F3N8OS. Mole weight: 550.65. | |
| LY255283 | This active molecular is a competitive leukotriene B4 receptor antagonist and IC50 value is about 100 nM. LY 255283 is selective for the BLT2 receptor, since IC50 values at the BLT1 receptor are >10 μM. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM. It also inhibits the binding of radiolabeled LTB4 to eosinophil membranes and IC50 value is 260 nM. LY255283 reduces airway obstruction in animal models of asthma. However, clinical trials for asthma had been discontinued. Uses: Asthma. Synonyms: LY 255283; LY255283; LY-255283; (1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone). Grades: 98%. CAS No. 117690-79-6. Molecular formula: C19H28N4O3. Mole weight: 360.45. | |
| LY-256548 | LY-25648 is a leukotriene B4 antagonist. Synonyms: LY 25648; LY-25648; LY25648; Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one;LY25648;5-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene-N-methyl-4-thiazolidinone;(5Z)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-3-methyl-1,3-thiazolidin-4-one. Grades: >98%. CAS No. 107889-31-6. Molecular formula: C19H27NO2S. Mole weight: 333.49. | |
| LY 257883 | LY 257883, also known as PPPA, is a competitive NMDA receptor antagonist which displays moderate selectivity for NR2A-containing receptors. Ki values are 0.13μM for NR2A, 0.47μM for NR2B, 1.10μM for NR2C and 3.86 μM for NR2D. Related experiments show that the increase in potency on raising of the extracellular pH results largely from an increase in the antagonist association rate constant but also from a small decrease in the dissociation rate constant. These results suggest that the fully ionized forms of the LY 257883 act as the active antagonist species at NMDA receptors. Synonyms: LY 257883; LY-257883; LY257883; 4-(3-phosphonopropyl)piperidine-2-carboxylic acid,PPPA. Grades: 98%. CAS No. 118183-22-5. Molecular formula: C9H18NO5P. Mole weight: 251.22. | |
| LY2603618 | LY2603618 is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. Synonyms: LY-2603618; LY 2603618; Rabusertib. Grades: >98%. CAS No. 911222-45-2. Molecular formula: C18H22BrN5O3. Mole weight: 436.31. | |
| LY2606368 dihydrochloride | The dihydrochloride salt form of LY2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. It is still under Phase II clinical trial against breast cancer and some other sorts of cancers. Uses: The dihydrochloride salt form of ly2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. Synonyms: UNII-9RFT476U2L; 9RFT476U2L; LY2606368 (dihydrochloride); 1234015-54-3; HY-18174A; CS-3507; CS 3507; CS3507; LY2606368; LY 2606368; LY-2606368. Grades: 98%. CAS No. 1234015-54-3. Molecular formula: C18H21Cl2N7O2. Mole weight: 438.31. | |
| LY2608204 | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
| LY 266097 hydrochloride | LY 266097 hydrochloride is a 5-HT2B receptor antagonist. It can attenuate amphetamine-induced locomotion in the rat. Synonyms: LY 266097 hydrochloride; LY266097 hydrochloride; LY-266097 hydrochloride; 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-39-5. Molecular formula: C21H23ClN2O2.HCl. Mole weight: 407.33. | |
| LY 269415 | LY 269415 is a 5-Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties in vitro. But no development was reported for Rheumatic disorders in USA. Uses: Rheumatic disorders. Synonyms: LY 269415; LY269415; LY-269415. 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(methylamino)-4-Thiazolidinone. Grades: 98%. CAS No. 132392-65-5. Molecular formula: C19H28N2O2S. Mole weight: 348.51. | |
| LY 272015 hydrochloride | LY 272015 hydrochloride is a selective 5-HT2B receptor antagonist. Synonyms: LY 272015 hydrochloride; LY272015 hydrochloride; LY-272015 hydrochloride; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-15-7. Molecular formula: C21H24N2O2.HCl. Mole weight: 372.89. | |
| LY 278584 | LY 278584 is a 5-HT3-receptor antagonist and no detailed information has been published yet. Synonyms: LY 278584; LY-278584; LY278584. 1-methyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]indazole-3-carboxamide. Grades: 98%. CAS No. 119193-37-2. Molecular formula: C17H22N4O. Mole weight: 298.39. | |
| LY2801653 | LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. Synonyms: LY-2801653; LY 2801653. Grades: >98%. CAS No. 1206799-15-6. Molecular formula: C30H22F2N6O3. Mole weight: 552.542. | |
| LY2801653 dihydrochloride | LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(I)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Synonyms: LY-2801653 dihydrochloride; LY 2801653 dihydrochloride. Grades: >98%. CAS No. 1206801-37-7. Molecular formula: C30H24Cl2F2N6O3. Mole weight: 625.45. | |
| LY2811376 | LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi Beta secretase (BACE) inhibitor (IC50 = 239-249 nM) with the potent effect of treating Alzheimer's Disease. In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1. In vitro, LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM. Synonyms: 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; LY 2811376; LY-2811376; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine. Grades: ≥95%. CAS No. 1194044-20-6. Molecular formula: C15H14F2N4S. Mole weight: 320.36. | |
| LY2828360 | LY2828360 is a selective cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). LY2828360 (3 mg/kg per day i.p. × 12 days) suppressed chemotherapy-induced neuropathic pain produced by paclitaxel without producing tolerance in wild-type mice. Synonyms: LY-2828360; LY 2828360; 8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine. Grades: ≥98%. CAS No. 1231220-79-3. Molecular formula: C22H27ClN6O. Mole weight: 426.94. | |
| LY285434 | An antagonist of angiotensin II receptor. Synonyms: LY285434; LY 285434; LY-285434; 2-[5-[2-(2H-tetrazol-5-yl)phenyl]indol-1-yl]octanoic acid. CAS No. 159748-08-0. Molecular formula: C23H25N5O2. Mole weight: 403.48. | |
| LY2857785 | LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. Synonyms: LY2857785; LY-2857785; LY 2857785. Grades: >98%. CAS No. 1619903-54-6. Molecular formula: C26H36N6O. Mole weight: 448.6. | |
| LY2874455 | LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. Synonyms: LY2874455; LY 2874455; LY-2874455. Grades: >98%. CAS No. 1254473-64-7. Molecular formula: C21H19Cl2N5O2. Mole weight: 444.316. | |
| LY 288513 | LY 288513 is a CCK2 receptor antagonist with IC50 value of 16nM. It shows anxiolytic and antipsychotic properties in vivo. Synonyms: LY 288513; LY288513; LY-288513; (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 147523-65-7. Molecular formula: C22H18BrN3O2. Mole weight: 436.3. | |
| LY2886721 | LY2886721, under the IUPAC name N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, is the first oral small molecule inhibitting Beta secretase (BACE) to reach Phase 2 clinical research. It was developed by Eli Lilly & Co. with the potention to treat Alzheimer's Disease. Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; LY2886721; LY-2886721; LY 2886721. CAS No. 1262036-50-9. Molecular formula: C18H16F2N4O2S. Mole weight: 390.41. | |
| LY 2886721 hydrochloride | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. Uses: Potential treatment of alzheimer's disease. Synonyms: LY 2886721 hydrochloride; LY2886721 hydrochloride; LY-2886721 hydrochloride; N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1262036-49-6. Molecular formula: C18H16F2N4O2S.HCl. Mole weight: 426.87. | |
| LY 292728 | LY 292728, an oxoxanthene derivative, has been found to be a leukotriene B4 receptor antagonist that has once been studied as an antiasthmatic agent. Synonyms: LY 292728; LY292728; LY-292728; CHEMBL292782; 9h-xanthene-4-propanoic acid, 7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo-; 9H-Xanthene-4-propanoicacid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propox. Grades: 98%. CAS No. 153034-77-6. Molecular formula: C34H29FO9. Mole weight: 600.60. | |
| LY 293284 | LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A with over 1000x selectivity over other serotonin receptor subtypes and other targets. No development was reported for the treatment of Anxiety disorders and Major depressive disorder. Uses: Anxiety disorders; major depressive disorder. Synonyms: LY 293284; LY293284; LY-293284. (R)-1-(4-(dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indol-6-yl)-Ethanone. Grades: 98%. CAS No. 141318-62-9. Molecular formula: C19H26N2O. Mole weight: 298.43. | |
| LY-293559 | LY 215490, a decahydroisoquinoline derivative, has been found to be an AMPA receptor antagonist that could be a neuroprotective agent in the study of focal ischaemia. Synonyms: LY-293559; LY 215490; LY-215490; CHEMBL70937; SCHEMBL3678843; ZINC5760; (3R,4aS,6S,8aS)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid. Grades: 98%. CAS No. 150010-68-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
| LY 293606 | GYKI-53405 is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) antagonist. It can bind to Xenopus brain membranes with KD and Bmax values of 4.5 mM and 35 pmol mg-1 protein respectively. Synonyms: GYKI-53405; GYKI 53405; GYKI53405; LY 293606; LY-293606; LY293606; 1-(4-Aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine. Grades: 98%. CAS No. 143691-37-6. Molecular formula: C19H19N3O3. Mole weight: 337.38. | |
| LY 2955303 hydrochloride | LY 2955303 hydrochloride is a potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) commonly used for the treatment of osteoarthritis joint pain. Uses: The treatment of osteoarthritis joint pain. Synonyms: LY 2955303 hydrochloride; LY2955303 hydrochloride; LY-2955303 hydrochloride; 4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid hydrochloride. Grades: 98%. Molecular formula: C36H42N4O3.HCl. Mole weight: 615.2. | |
| LY2979165 | LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants. Synonyms: LY-2979165; LY 2979165. Grades: 0.98. CAS No. 1311385-32-6. Molecular formula: C13H22N6O6S. Mole weight: 390.415. | |
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