BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Methyllycaconitine citrate | Methyllycaconitine citrate is a potent and specific nicotinic receptor antagonist that binds to neuronal α-bungarotoxin sites (Ki = 1.4 nM). It interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Synonyms: [1α , 4 (S) , 6β , 14α , 16β ]-20-Ethyl-1, 6, 14, 16-tetramethoxy-4-[[[2- (3-methyl-2, 5-dioxo-1-pyrrolidinyl) benzoyl]oxy]methyl]aconitane-7, 8-diol citrate. CAS No. 112825-05-5. Molecular formula: C37H50N2O10.C6H8O7. Mole weight: 874.93. |  |
| Methylpiperidino pyrazole | Methylpiperidino pyrazole is a high-affinity and selective ERα antagonist, exhibiting 200-fold potency for ERα over ER&beta. Synonyms: MPP; 4-[1-(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidin-1-ylethoxy)phenyl]pyrazol-3-yl]phenol. Grades: ≥98%. CAS No. 289726-02-9. Molecular formula: C29H31N3O3. Mole weight: 469.6. | |
| Methysergide | Methysergide is an ergot derivative that is a congener of lysergic acid diethylamide for the treatment of vascular headache. Uses: An ergot derivative that is a congener of lysergic acid diethylamide. Synonyms: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-4,7-dimethyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide;UML 491; UML491; UML-491. Grades: ≥98%. CAS No. 361-37-5. Molecular formula: C21H27N3O2. Mole weight: 353.46. | |
| Methysticin | Methysticin is a natural kavalactone found in the kava plant. It induces hepatic CYP1A1 enzyme. Study in a mouse model of Alzheimer's disease has shown that methysticin activated the Nrf2 pathway and improved cognitive ability. Synonyms: 2H-Pyran-2-one, 6-[(1E)-2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, (6R)-; (6R)-6-[(1E)-2-(1,3-Benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one; 2H-Pyran-2-one, 5,6-dihydro-4-methoxy-6-[3,4-(methylenedioxy)styryl]-, (R)-; 2H-Pyran-2-one, 6-[2-(1,3-benzodioxol-5-yl)ethenyl]-5,6-dihydro-4-methoxy-, [R-(E)]-; (+)-Methysticin; d-Methysticin; Kavahin; Kavatin; Methysticin; NSC 112158. Grades: ≥98%. CAS No. 495-85-2. Molecular formula: C15H14O5. Mole weight: 274.27. | |
| Metiamide | Metiamide is developed from another burimamide, used as a histamine H2 receptor antagonist. Uses: Metrizamide is used for lumbar, thoracic, cervical, and total columnar myelography to determine the presence of abnormalities in the spinal column, spinal canal, and central nervous system (cns) as well as for cisternography by direct injection using stan. Synonyms: WIN 39103; WIN39103; WIN-39103; SKF 92058; SKF92058; SKF-92058; NSC 307755; NSC307755; NSC-3077553-[(1-hydroxyethylidene)amino]-2,4,6-triiodo-5-(N-methylacetamido)-N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]benzene-1-carboximidic acid. Grades: ≥98%. CAS No. 34839-70-8. Molecular formula: C9H16N4S2. Mole weight: 244.385. | |
| Metoprolol succinate | Metoprolol succinate is a selective β-adrenoceptor antagonist. It is used in treatment of several diseases of the cardiovascular system. It is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia. Uses: Metoprolol succinate is used in treatment of several diseases of the cardiovascular system. it is a drug used in the treatment of patients suffering from hypertension, coronary heart disease, chronic heart failure and arrhythmia. Synonyms: 2-Propanol, 1-(4-(2-Methoxyethyl)phenoxy)-3-((1-Methylethyl)aMino)-, (+-)-, butanedioate (2:1) (salt);Butanedioic acid 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol;Toprol XL;Spesicor Dos;Selozok. Grades: 95%. CAS No. 98418-47-4. Molecular formula: C34H56N2O10. Mole weight: 652.83. | |
| MF498 | MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, a Gs protein-coupled receptor, with Ki of 0.7 nM. It plays important roles in bone formation and resorption, inflammation, cancer, and atherosclerosis. It has been shown to inhibit inflammation without gastrointestinal toxicity in various animal models for arthritis. It also displays a relatively good selectivity over other prostanoid receptors. It does not compromise the mucosal integrity in the gastrointestinal tract in vitro. It inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner. It relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis in vivo. Uses: Mf498 plays important roles in bone formation and resorption, inflammation, cancer, and atherosclerosis. it has been shown to inhibit inflammation without gastrointestinal toxicity in various animal models for arthritis. it relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis in vivo. Synonyms: MF498; MF 498; MF-498; C 528911; C-528911; C528911; N-[[[4-(5,9-Diethoxy-6,8-dihydro-6-oxo-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methyl]sulfonyl]-2-methoxy-benzeneacetamide;N-[[4-(5,9-diethoxy-6-oxo-8H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylphenyl]methylsulfonyl]-2-(2-methoxyphenyl)acetamide. Grades: >98%. CAS No. 915191-42-3. Molecular formula: C32H33N3O7S. Mole weight: 603.69. | |
| MF592 | MF592 is a potent and selective antagonists of the EP4 receptor. It has good functional potency and potent inhibition of PGE2 modulated TNFa release in LPS stimulated human whole blood (hWB). It displays an excellent oral pharmacokinetic (PK) profile and in vivo efficacy in a rat chronic adjuvant-induced-arthritis model. It has a desirable overall preclinical profile that suggests it is suitable for further development. Synonyms: MF-592; MF 592; MF592; 2, 6-Dichloro-N- ( (1- (4- (4, 9-diethoxy-1-oxo-1, 3-dihydro-2H-benzo[f]isoindol-2-yl) -3-methylbenzyl) cyclopropyl) carbamoyl) benzenesulfonamide. Grades: >98%. CAS No. 1064195-48-7. Molecular formula: C34H33Cl2N3O6S. Mole weight: 682.61. | |
| Mf-63 | Mf-63 is a selective Microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Its IC50 value is 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively. It displays greater than 1,000-fold selectivity over other prostanoid synthases. It strongly inhibited guinea pig mPGES-1 but not the mouse or rat enzyme in rodent species. It did not cause NSAID-like gastrointestinal toxic effects that is caused by non-selective COX inhibitors, although it markedly suppresses PGE2 synthesis in the stomach. It prevents LPS-induced hyperglasia. It has anti-inflammatory, analgesic and anti-cancer agent. Uses: Mf-63 has anti-inflammatory, analgesic and anti-cancer agent. Synonyms: 2-(9-Chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-1,3-benzenedicarbonitrile;2-(6-chloro-1H-phenanthro-[9,10-d]iMidazol-2-yl)isophthalonitrile;MF-63; MF63; MF 63. Grades: >98%. CAS No. 892549-43-8. Molecular formula: C23H11ClN4. Mole weight: 378.81. | |
| MFZ 10-7 | MFZ 10-7 is a mGlu5 receptor negative allosteric modulator. It can inhibit mGlu5 glutamate-mediated calcium mobilization with IC50 value of 1.22 nM. MFZ 10-7 can inhibit cocaine-taking and cocaine-seeking behavior in rats. Synonyms: 3-Fluoro-5-[2-(6-methyl-2-pyridinyl)ethynyl]benzonitrile hydrochloride. Grades: ≥99% by HPLC. CAS No. 1224431-15-5. Molecular formula: C15H9FN2.HCl. Mole weight: 272.7. | |
| MG 1 | An α1 adrenergic receptor antagonist. Synonyms: MG 1; MG1; MG-1; 1-[2-hydroxy-3-(4-phenylpiperazin-1-yl)propyl]pyrrolidin-2-one; N-(2-hydroxy-3-(N-phenylpiperazinepropyl))-2-pyrrolidinone; N-(2-OH-3-PPP)-2-pyrrolidinone; N-(beta-hydroxy-gamma-(N-phenylpiperazinepropyl))-2-pyrrolidinone. CAS No. 148274-76-4. Molecular formula: C17H25N3O2. Mole weight: 303.4. | |
| MG149 | MG149 is a potent histone acetyltransferase inhibitor with IC50 of 74 μM and 47 μM for Tip60 and MOF,respectively. Synonyms: MG149; MG 149; MG-149. Grades: >98%. CAS No. 1243583-85-8. Molecular formula: C22H28O3. Mole weight: 340.46. | |
| MG 624 | MG624 is a neuronal nicotinic acetylcholine receptors antagonist. It is selective for neuronal nAChRs over muscle-type AChRs. It can decrease vagus nerve stimulation-induced contractions of isolated guinea pig vagus nerve-stomach preparations. Synonyms: MG624; MG 624; MG-624; N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide. Grades: ≥98% by HPLC. CAS No. 77257-42-2. Molecular formula: C22H30NOI. Mole weight: 451.39. | |
| MGA271 | Enoblituzumab is a monoclonal antibody designed for the treatment of cancer. Formerly known as MGA271, the drug is a humanized IgG1κ monoclonal antibody recognizing human. B7-H3, a member of the B7 family of immune regulators. Synonyms: MGA271; MGA 271; MGA-271; Enoblituzumab; UNII-M6030H73N9. CAS No. 1353485-38-7. Molecular formula: C6474H9990N1726O2030S42. | |
| MGCD-265 | MGCD-265 is a potent, multi-target and ATP-competitive inhibitor of c-Met and VEGFR1/2/3 with IC50 of 1 nM, 3 nM/3 nM/4 nM, respectively and also inhibits Ron and Tie2. Synonyms: MGCD-265; MGCD 265; MGCD265; MGCD-265-analog; MGCD 265-analog; MGCD265-analog. Glesatinib-analog. Grades: >98%. CAS No. 875337-44-3. Molecular formula: C26H20FN5O2S2. Mole weight: 517.60. | |
| MHY1485 | mTOR activator with an inhibitory effect on autophagy. MHY1485 markedly increased the LC3II/LC3I ratio dose-dependently and time-dependently by inhibition of the fusion between autophagosomes and lysosomes, and without increasing the autophagic flux. At 2 μM, MHY1485 did not show any cell death during longer treatment, supporting that MHY1485 had less toxicity than other well-known inhibitors of autophagy. MHY1485 was also tested and found moderately active as antimalarial agent (MIC value of ca. 26 μM against P. Falciparum). Synonyms: MHY-1485; MHY1485; MHY 1485. Grades: >98%. CAS No. 326914-06-1. Molecular formula: C17H21N7O4. Mole weight: 387.39. | |
| MHY 908 | MHY 908 is a dual PPARα/γ agonist and a melanogenesis inhibitor that suppresses mushroom tyrosinase activity (IC50 value 8.19 μM). MHY908 exhibits more potent activation of PPARα and PPARγ than fenofibrate and rosiglitazone, and enhances the binding and transcriptional activity of PPARα and -γ in AC2F cells. It reduces serum glucose, triglyceride, and insulin levels, however increases adiponectin levels without body weight gain. Synonyms: MHY908; MHY 908; MHY-908; 2-[4-(5-Chloro-2-benzothiazolyl)phenoxy]-2-methylpropanoic acid. Grades: 99%. CAS No. 1393371-39-5. Molecular formula: C17H14ClNO3S. Mole weight: 347.82. | |
| MI-136 | MI-136, with the potential to treat refractory prostate cancer, inhibits DHT-induced expression of androgen receptor (AR) target genes. In vitro: Treatment with MI-136 inhibits the expression of genes that are bound to ASH2L after AR stimulation and induc. Synonyms: 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrileMI-136; MI 136; MI1365-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile5-[(4-{[6-(2,2,2-Tri. CAS No. 1628316-74-4. Molecular formula: C23H21F3N6S. Mole weight: 470.51. | |
| MI-192 | MI-192 is a selectively histone deacetylases inhibitor (HDACs) that preferentially inhibits HDAC2 with IC50 value of 30 nM and HDAC3 with IC50 value of 16 nM over HDAC1, 4, 6, 7, and 8 (IC50s = 4.8, 5, >10, 4.1, and >10 μM, respectively). MI-192 can promote apoptosis of leukemia cell lines in vitro. It also can attenuate IL-6 production in rheumatoid arthritis PBMCs in vitro. Synonyms: MI-192; MI 192; MI192; N-(2-aminophenyl)-4-[(3,4-dihydro-4-methylene-1-oxo-2(1H)-isoquinolinyl)methyl]-benzamide. Grades: 98%. CAS No. 1415340-63-4. Molecular formula: C24H21N3O2. Mole weight: 383.45. | |
| MI-2 | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. Synonyms: MI-2 ; Menin-MLL inhibitor 2; Menin-MLL Inhibitor. Grades: >98%. CAS No. 1271738-62-5. Molecular formula: C18H25N5S2. Mole weight: 375.55. | |
| MI-3 | MI-3 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 648 nM. Synonyms: Menin-MLL Inhibitor; MI3; MI 3; MI-3. Grades: >98%. CAS No. 1271738-59-0. Molecular formula: C18H25N5S2. Mole weight: 375.55. | |
| MI-503 | MI-503 is a potent, selective and orally bioavailable Menin-MLL inhibitor (IC50 = 14.7 nM). It is used in the pharmacological inhibition of menin-MLL interaction that blocks progression of MLL leukemia in vivo. It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines (GI50 at 250 nM-570 nM range), but only a minimal effect in human leukemia cell lines without MLL translocations. Synonyms: MI-503; MI 503; MI503; 4-methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indole-2-carbonitrile; 4-Methyl-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]-1-piperidinyl]methyl]-1H-indole-2-carbonitrile. Grades: 99.16 %. CAS No. 1857417-13-0. Molecular formula: C28H27F3N8S. Mole weight: 564.63. | |
| MI-773 | MI-773, a spirooxindole derivative, is a MDM2 antagonist that has probable effect in the treatment of sorts of cancers. It has already discontinued the Phase I trial against solid tumor. Uses: Mi-773 is a mdm2 antagonist that has probable effect in the treatment of sorts of cancers. Synonyms: MI-773; MI 773; MI773; C29H34Cl2FN3O3; SCHEMBL6882778; SCHEMBL15214439; SCHEMBL15214524. Grades: 98%. CAS No. 1303607-07-9. Molecular formula: C29H34Cl2FN3O3. Mole weight: 562.50. | |
| Mianserin | Mianserin is a tetracyclic second generation antidepressant. It has the same efficacy as the tricyclics, but has no anticholinergic and cardiovascular side-effects. It also has antiemetic (nausea and vomiting-attenuating), orexigenic (appetite-stimulating. Synonyms: 1, 2, 3, 4, 10, 14b-hexahydro-2-methyldibenzo(c, f)pyrazino(1, 2-a)azepine; f)pyrazino(1, 2-a)azepine, 1, 2, 3, 4, 10, 14b-hexahydro-2-methyl-dibenzo(; MIANSERIN; MIANSERINE; Dibenzoc, fpyrazino1, 2-aazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-;MIANSERIN,1.0MG/MLINMETHANOL;D. Grades: 95%. CAS No. 24219-97-4. Molecular formula: C18H20N2. Mole weight: 264.3649. | |
| Mibefradil | Mibefradil, a calcium channel blocker, has modest selectivity for T-type Ca2+ channels so that could be used in the treatment of sorts of cardiovascular disease like hypertension and chronic angina pectoris. IC50: 2.7 μM (for T-type). Uses: Mibefradil is a calcium channel blocker and has modest selectivity for t-type ca2+ channels so that could be used in the treatment of sorts of cardiovascular disease like hypertension and chronic angina pectoris. Synonyms: Mibefradil;Mibefradil dihydrochloride. Grades: >98 %. CAS No. 116644-53-2. Molecular formula: C29H38FN3O3. Mole weight: 568.55. | |
| MIK665 | MIK665 is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with potential pro-apoptotic and antineoplastic activities. Synonyms: MIK-665; MIK 665; S64315; 2-[5-[3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid. CAS No. 1799631-75-6. Molecular formula: C47H44ClFN6O6S. Mole weight: 875.41. | |
| Milameline hydrochloride | Milameline is a non-selective muscarinic acetylcholine receptor partial agonist at all receptor subtypes (Ki values are 2.3, 2.4, 3.6, 3.8 and 4.3 μM for hM1, hM2, hM3, hM4 and hM5 receptors respectively). In Sep 2000, phase III clinical trials for Alzheimer's disease were discontinued in European Union and USA. Uses: Alzheimer's disease. Synonyms: CI979; CI 979; CI-979; Milameline; (E)-1-methyl-1,2,5,6-tetrahydropyridine-3-carbaldehyde O-methyl oxime hydrochloride. Grades: 98%. CAS No. 139886-04-7. Molecular formula: C8H15ClN2O. Mole weight: 190.67. | |
| Milveterol | Milveterol is a long-acting β(2)-adrenoceptor agonist. It is potentially useful for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. It was developed by GlaxoSmithKline and Theravance together. It was in clinic phase 2 trials, but now it is terminated. Uses: Milveterol is potentially useful for the treatment of chronic obstructive pulmonary disease (copd) and asthma. Synonyms: GSK159797; GSK 159797; GSK-159797; N- [2-hydroxy-5- [ (1R) -1-hydroxy-2- [2- [4- [ [ (2R) -2-hydroxy-2-phenylethyl] amino] phenyl] ethylamino] ethyl] phenyl] formamide; GSK-159797. Grades: 98%. CAS No. 652990-07-3. Molecular formula: C25H29N3O4. Mole weight: 435.52. | |
| Milveterol hydrochloride | Milveterol is a long-acting β(2)-adrenoceptor agonist under the development of GlaxoSmithKline. Phase II trials for the treatment of Chronic obstructive pulmonary disease were discontinued. Uses: Chronic obstructive pulmonary disease. Synonyms: GSK 159797; GSK159797; GSK-159797; Milveterol; N- [2-hydroxy-5- [ (1R) -1-hydroxy-2- [2- [4- [ [ (2R) -2-hydroxy-2-phenylethyl] amino] phenyl] ethylamino] ethyl] phenyl] formamide; hydrochloride. Grades: 98%. CAS No. 804518-03-4. Molecular formula: C25H30ClN3O4. Mole weight: 471.98. | |
| MIM1 | MIM1 is a small molecule inhibitor of Mcl-1 (IC50= 4.8 uM) by selectively targets the BH3-binding pocket. Uses: Mcl-1 inhibitor. Synonyms: AC1OBINW; MIM1; MIM 1; MIM-14-[[(2-cyclohexylimino-4-methyl-1,3-thiazol-3-yl)amino]methylidene]-2,3-dihydroxycyclohexa-2,5-dien-1-one. Grades: ≥98%. CAS No. 509102-00-5. Molecular formula: C17H21N3O3S. Mole weight: 347.43. | |
| Minaprine | Minaprine, also called as Agr 1240 or Cantor, an atypical antidepressant drug which is effective in most animal models of depression, is a reversible inhibitor of MAO-A and weakly inhibits acetylcholinesterase. Synonyms: 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine Agr 1240 Cantor minaprine minaprine dihydrochloride MINAPRINE HYDRO. CAS No. 25905-77-5. Molecular formula: C17H22N4O. Mole weight: 298.38. | |
| Minaprine hydrochloride | Minaprine hydrochloride is the hydrochloride salt form of Minaprine. Minaprine, also called as Agr 1240 or Cantor, an atypical antidepressant drug which is effective in most animal models of depression, is a reversible inhibitor of MAO-A and weakly inhibi. Synonyms: 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine;dihydrochloride 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine Agr 1240 Cantor minaprine minaprine dihydrochloride. CAS No. 25953-17-7. Molecular formula: C17H24Cl2N4O. Mole weight: 371.3. | |
| Miransertib hydrochloride | Miransertib is an orally bioavailable and selective AKT pathway inhibitor that suppresses AKT1, 2, 3 isoforms. It binds to both the active and inactive forms of AKT. Miransertib inhibits PIK3CA/AKT1 mutant dependent kinase signaling and exhibits antitumor activity. Synonyms: Miransertib; ARQ 092 HCl; Miransertib HCl; 3-[3-[4-(1-aminocyclobutyl)phenyl]-5-phenylimidazo[4,5-b]pyridin-2-yl]pyridin-2-amine hydrochloride. CAS No. 1313883-00-9. Molecular formula: C27H25ClN6. Mole weight: 468.98. | |
| Mirisetron maleate | Mirisetron maleate, an oxoquinoline derivative, has been found to be a 5-HT3 receptor antagonist that could probably be effective against anxiety disorders and sleep disorders. It has been already discontinued by Wyeth. Synonyms: MIRISETRON MALEATE; 148611-75-0; UNII-0B4615FL1S; Mirisetron maleate (USAN); AC1O5KJ1; SCHEMBL121861; (Z)-but-2-enedioic acid;1-cyclohexyl-N-[(1S,5R)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-4-oxoquinoline-3-carboxamide. Grades: 98%. CAS No. 148611-75-0. Molecular formula: C28H35N3O6. Mole weight: 509.60. | |
| Mirk-IN-1 | Mirk-IN-1, a pyrido[2,3-d]pyrimidine derivative, has been found to be a DYRK1A/B inhibitor and probably have antitumor activity through influencing the accumulation and induce the DNA damage and apoptosis of Panc1 in tumor cells. IC50: 68±48/22±8 nM (Dyrk. Uses: Mirk-in-1 has been found to be a dyrk1a/b inhibitor and probably have antitumor activity through influencing the accumulation and induce the dna damage and apoptosis of panc1 in tumor cells. Synonyms: Dyrk1B/1A-IN-9; Dyrk1B inhibitor; 1A-IN-9; Dyrk-1B/1A-IN-9; Dyrk 1B/1A IN 9; Dyrk1B/1A-inhibitor-9; Mirk-IN-1; CHEMBL3094448; SCHEMBL10446906; CQKBSRPVZZLCJE-UHFFFAOYSA-N; BDBM50444379; AKOS025147328; N-[2-chloro-5-[(3-chlorophenyl)methylcarbamoyl]phenyl]-2-methoxy-7-oxo-8H-pyrido[2,3-d]pyrimidine-6-carboxamide. Grades: 98%. CAS No. 1386979-55-0. Molecular formula: C23H17Cl2N5O4. Mole weight: 498.32. | |
| Mirogabalin besylate | Mirogabalin besylate is a selective and orally available ligand for the voltage-gated calcium channel α2δ subunit and is being developed for the treatment of pain associated with diabetic peripheral neuropathy, fibromyalgia and post-herpetic neuralgia. Synonyms: DS-5565; DS 5565; DS5565; A-2000700. Grades: 98%. CAS No. 1138245-21-2. Molecular formula: C18H25NO5S. Mole weight: 367.5. | |
| Mitonafide | Mitonafide is a naphthalimide with potent anticancer activity. Mitonafide was shown in early clinical trials to be toxic to the central nervous system when administered as a short intravenous infusion. Uses: A naphthalimides with potent anticancer activity. Synonyms: N-(2-(Dimethylamino)ethyl)-3-nitronaphthalimide; 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione; M-4212. Grades: 95%. CAS No. 54824-17-8. Molecular formula: C16H15N3O4. Mole weight: 313.31. | |
| MIV-150 | MIV-150 is an allosteric inhibitor of HIV-1 and HIV-2 reverse transcriptase with both EC50 values of 1 nM in vitro. Synonyms: PC-815; 1-(5-cyanopyridin-2-yl)-3-[(1S,2S)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea. Grades: ≥98%. CAS No. 231957-54-3. Molecular formula: C19H17FN4O3. Mole weight: 368.4. | |
| Mivacurium chloride | Mivacurium is a nicotinic acetylcholine receptors (nAChRs) antagonist and a non-depolarizing neuromuscular-blocking drug metabolized by plasma cholinesterase. Grades: ≥95%. CAS No. 106861-44-3. Molecular formula: C58H80Cl2N2O14. Mole weight: 1100.2. | |
| Mivorilaner | Mivorilaner is an antineoplastic and antiparasitic primarily used in veterinary medicine. Synonyms: Itabh-19-01; LY 3116151; LY3116151; LY-3116151. Grades: >98%. CAS No. 1414642-93-5. Molecular formula: C22H17Cl2F6N3O3S. Mole weight: 588.3. | |
| Mizolastine dihydrochloride | The dihydrochloride salt form of Mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy symptoms for playing the role as a histamine H1-receptor antagonis. IC50: 47nM. Uses: The dihydrochloride salt form of mizolastine which is effective in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis and other allergy symptoms for playing the role as a histamine h1-receptor antagonis. Synonyms: Mizolastine (dihydrochloride); CS-1998. Grades: 98%. CAS No. 1056596-82-7. Molecular formula: C24H27Cl2FN6O. Mole weight: 505.42. | |
| MJ 15 | MJ 15 is a CB1 receptor antagonist with IC50 value of 118.9 pM for rat CB1 receptors. It can inhibit food intake and increase body weight in diet-induced obese rats and mice. Synonyms: MJ15; MJ 15; MJ-15; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(3-pyridinylmethyl)-1H-pyrazole-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 944154-76-1. Molecular formula: C23H17Cl3N4O. Mole weight: 471.77. | |
| MJ33 lithium salt | MJ33 is a selective and reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6. Prdx6 is a bifunctional enzyme with both non-selenium glutathione peroxidase (Gpx) and PLA2 activities. Synonyms: 1-Hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol, Li. Grades: ≥95%. CAS No. 1007476-63-2. Molecular formula: C22H43F3LiO6P. Mole weight: 498.5. | |
| MK-0249 | This active molecular is a potent histamine H3 inverse antagonist. Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. MK-0249 might improve cognitive deficits in patients with schizophrenia in due to promote histamine release that may enhance cognition. In Dec 2006, Phase-II clinical trials in Alzheimer's disease in USA was on going. In Dec 2009, adverse events data from a clinical trial in healthy subjects was presented. In Jun 2012, Pharmacodynamics data from a phase I trial in Sleep apnoea syndrome was reported by Merck. Uses: Alzheimer's disease; attention-deficit hyperactivity disorder; obesity; schizophrenia; sleep apnoea syndrome. Synonyms: MK0249; MK 0249; MK-0249; 2-methyl-3-[4-(3-pyrrolidin-1-ylpropoxy)phenyl]-5-(trifluoromethyl)quinazolin-4-one. Grades: 98%. CAS No. 1167574-41-5. Molecular formula: C23H24F3N3O2. Mole weight: 431.45. | |
| MK 0343 | MK 0343, also known as MRK-409, is a subtype-selective GABAA partial agonist (Ki values are 0.21, 0.22, 0.23 and 0.40 for α3, α1, α5 and α2 respectively). MK-0343 is a non-sedating anxiolytic in preclinical species but causes sedation in humans. Synonyms: 7-cyclobutyl-3-(2,6-difluorophenyl)-6-((1-methyl-1H-1,2,4-triazol-5-yl)methoxy)-[1,2,4]triazolo[4,3-b]pyridazine; MK-0343; MK 0343; MK0343; MRK 409; MRK409; MRK-409. Grades: >98%. CAS No. 233275-76-8. Molecular formula: C19H17F2N7O. Mole weight: 397.38. | |
| MK 0524 sodium salt | MK 0524 sodium salt is a potent and selective prostaglandin D2 (PGD2) receptor 1 (DP1) antagonist with Ki values to be 0.57 nM and 750 nM for DP1 and DP2 receptors, respectively. Synonyms: MK 0524 sodium salt; MK0524 sodium salt; MK-0524 sodium salt; Laropiprant sodium; 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid sodium. Grades: 99%. CAS No. 572874-50-1. Molecular formula: C21H18ClFNNaO4S. Mole weight: 457.88. | |
| MK-0591 | Quiflapon is a synthetic compound which specifically inhibits the activity of 5-Lox and is currently under development for the treatment of asthma. Also, Quiflapon, a leukotriene biosynthesis inhibitor, induces apoptosis in prostate cancer cells. Synonyms: Quiflapon; MK 591; MK-591; MK591; L 686708; L-686708; L686708; L-686,708; L 686,708; L686,708. Grades: >98%. CAS No. 136668-42-3. Molecular formula: C34H35ClN2O3S. Mole weight: 587.17. | |
| MK-0634 | MK-0634, also called as L-796568, is an β3 adrenergic receptor agonist that was progressed into clinical studies for the treatment of obesity in the early 2000s but discontinued due to unacceptable toxicity. Synonyms: MK-0634; MK 0634; MK0634; N-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl]benzenesulfonamide; 2-hydroxy-PEAPTTB; L-796568 free base; L 796568 free base; L796568 free base; 211031-81-1 (L-796568 dihydrochloride); N-(4-(2-((2-hydroxy-2-(3-pyridinyl)ethyl)amino)ethyl)phenyl)-4-(4-(4-(trifluoromethyl)phenyl)thiazol-2-yl)benzenesulfonamide. Grades: >98%. CAS No. 211031-01-5. Molecular formula: C31H27F3N4O3S2. Mole weight: 624.697. | |
| MK-0634 dihydrochloride | MK-0634, also called as L-796568, is an β3 adrenergic receptor agonist that was progressed into clinical studies for the treatment of obesity in the early 2000s but discontinued due to unacceptable toxicity. Uses: Adrenergic beta-3 receptor agonists. Synonyms: N-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-4-[4-[4-(trifluoromethyl)phenyl]-1, 3-thiazol-2-yl]benzenesulfonamide; dihydrochloride; L-796568 dihydrochloride; 211031-81-1 (L-796568 dihydrochloride); 211031-01-5 (L-796568 Free base); MK 0634 dihydrochloride; MK0634 dihydrochloride; MK-0634 dihydrochloride; L-796568 dihydrochloride; L 796568 dihydrochloride; L796568 dihydrochloride. Grades: >98%. CAS No. 211031-81-1. Molecular formula: C31H29Cl2F3N4O3S2. Mole weight: 697.61. | |
| MK0686 | MK0686 is a bradykinin B1 receptor antagonist. It exhibits suitable pharmacokinetic properties and efficient ex vivo receptor occupancy for further development as a novel approach for the treatment of pain and inflammation. It had been in phase II clinical trials by Merck Sharp & Dohme for the treatment of postherpetic neuralgia, postoperative pain and osteoarthritis. But it is discontinued now. Uses: Mk0686 is used for the treatment of postherpetic neuralgia, postoperative pain and osteoarthritis. Synonyms: MK0686; MK 0686; MK-0686;Methyl 2-chloro-6- [3-fluoro-4- [ (1R) -1- [ [1- [ (2, 2, 2-trifluoroacetyl) amino] cyclopropanecarbonyl] amino] ethyl] phenyl] benzoate; Methyl (R)-3-chloro-3'-fluoro-4'-(1-(1-(2,2,2-trifluoroacetamido)cyclopropane-1-carboxamido)ethyl)-[1,1'-biphenyl]-2-carboxyla. Grades: 98%. CAS No. 578727-68-1. Molecular formula: C22H19ClF4N2O4. Mole weight: 486.85. | |
| MK-0752 sodium salt | MK-0752 sodium salt is a novel potent γ-secretase inhibitor. It is in clinical trial for treatment of several types of cancer. Uses: Mk-0752 sodium salt is used for treatment of several types of cancer. Synonyms: MK0752; MK 0752; MK-0752; MK0752 sodium salt;Sodium 3-(4-((4-chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoate. Grades: 98%. CAS No. 656810-87-6. Molecular formula: C21H20ClF2NaO4S. Mole weight: 464.88. | |
| MK-0812 | MK-0812 is a potent and selective CCR2 antagonist with low affinity for CCR2 on human monocytes. Synonyms: MK-0812; MK 0812; MK0812; [(1S,3R)-3-[[(3S,4S)-3-methoxyoxan-4-yl]amino]-1-propan-2-ylcyclopentyl]-[3-(trifluoromethyl)-7,8-dihydro-5H-1,6-naphthyridin-6-yl]methanone. CAS No. 624733-88-6. Molecular formula: C24H34F3N3O3. Mole weight: 469.54. | |
| MK 0893 | MK-0893 is a potent, selective glucagon receptor antagonist with high binding affinity with IC(50) of 6.6 nM and functional cAMP activity with IC(50) of 15.7 nM. It is selective for glucagon receptor relative to other family B GPCRs and is > 200 fold selectivity for GIPR, PAC1, GLP-1R, VPAC1 and VPAC2. It blunted glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys. It may be a potential oral treatment for type 2 diabetes. It was selected for further preclinical and clinical evaluations. Uses: Mk-0893 may be a potential oral treatment for type 2 diabetes. Synonyms: MK 0893; MK0893; MK-0893; b-Alanine, N-[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-;Merk Glucagon antagonist;N-[4-[(1S)-1-[3-(3,5-Dichlorophenyl)-5-(6-methoxy-2-naphthalenyl)-1H-pyrazol-1-yl]ethyl]benzoyl]-beta-alanine;(S)-3-(4-(1-(3-(3,5-Dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl)ethyl)benzamido)propanoic acid. Grades: >98 %. CAS No. 870823-12-4. Molecular formula: C32H27Cl2N3O4. Mole weight: 588.48. | |
| MK-0941 mesylate | MK-0941 is a glucokinase activator used for the treatment of type II diabetes. It increases the risk of hypoglycemia and elevations in triglycerides and blood pressure. Synonyms: MK-0941; MK 0941; MK0941; 3-(6-ethylsulfonylpyridin-3-yl)oxy-5-[(2S)-1-hydroxypropan-2-yl]oxy-N-(1-methylpyrazol-3-yl)benzamide mesylate. Grades: ≥98%. CAS No. 1137916-97-2. Molecular formula: C21H24N4O6S·CH3SO3H. Mole weight: 556.61. | |
| MK-0969 | MK-0969 is an Muscarinic M3 antagonist which has the potential for the treatment of chronic obstructive pulmonary diseases. Synonyms: (2R)-N-[1-[(6-aminopyridin-2-yl)methyl]piperidin-4-yl]-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxy-2-phenylacetamide; MK0969; MK 0969; MK-0969; J-104135; J 104135; J104135. Grades: >98%. CAS No. 203321-88-4. Molecular formula: C24H30F2N4O2. Mole weight: 444.53. | |
| MK-2048 | MK-2048 is a second generation integrase inhibitor (IC50=2.6 nM). It can inhibits the HIV enzyme integrase 4 times longer than raltegravir. Synonyms: MK2048; MK 2048; MK-2048. Grades: >98%. CAS No. 869901-69-9. Molecular formula: C22H24FN5O4. Mole weight: 441.46. | |
| MK212 | MK212 is a 5HT2C-receptor agonist. It exhibited anxiolytic activity in mice at low doses. It is a serotonin agonist. It could promote the secretion of serum prolactin and cortisol in humans. Uses: Mk212 exhibites anxiolytic activity and could promote the secretion of serum prolactin and cortisol in humans. Synonyms: MK212; MK 212; MK-212; 2-Chloro-6-(1-piperazinyl)pyrazine;MK-212;2-Chloro-6-(piperazin-1-yl)pyrazine. Grades: 98%. CAS No. 64022-27-1. Molecular formula: C8H11ClN4. Mole weight: 198.65. | |
| MK212 hydrochloride | MK212 hydrochloride is a selective 5-HT2C serotonin receptor agonist. It displays selectivity for 5-HT2C over 5-HT2A with IC50 values of 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively. Uses: Serotonin receptor agonists. Synonyms: MK212; MK 212; MK-212; MK-212 hydrochloride;1-(6-Chloro-2-pyrazinyl)piperazine monohydrochloride;2-Chloro-6-(1-piperazinyl)pyrazine monohydrochloride. Grades: 98%. CAS No. 61655-58-1. Molecular formula: C8H12Cl2N4. Mole weight: 235.11. | |
| MK-2206 | MK-2206 is an allosteric inhibitor of Akt that prevents translocation of Akt to membranes. It is also an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It induces G1-phase cell cycle arrest in hepatocellular carcinoma cells, inhibits cell proliferation in non-small cell lung cancer cells, and inhibits proliferation in medullary thyroid cancer cells. It also inhibits tumor growth in animal models of nasopharyngeal cancer. It was developed by Merck Sharp & Dohme and in clinic phase 2 trials. Uses: Mk-2206 has potential antineoplastic activity. Synonyms: MK2206; MK 2206; MK-2206; 8-(4-(1-Aminocyclobutyl)phenyl)-9-phenyl-8,9-dihydro-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one;8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one. Grades: 95%. CAS No. 1032349-93-1. Molecular formula: C25H21N5O. Mole weight: 407.47. | |
| MK-2206 hydrochloride | MK-2206 hydrochloride is the hydrochloride form of MK-2206, which is an allosteric inhibitor of Akt and an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B). It has potential antineoplastic activity. It exhibits anticancer chemotherapeutic activity in a variety of in vitro cancer models. It inhibits tumor growth in animal models of nasopharyngeal cancer. Uses: Mk-2206 hydrochloride has potential antineoplastic activity. Synonyms: MK-2206 hydrochloride; MK 2206 hydrochloride; 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one hydrochloride;MK2206 hydrochloride. Grades: >98 %. CAS No. 1032349-77-1. Molecular formula: C25H22ClN5O. Mole weight: 443.93. | |
| MK-2295 | MK-2295 is a potent TRPV1 antagonist. TRPV1 antagonists has the potential as analgesic and anti-inflammatory agents. Synonyms: MK-2295; MK 2295; MK2295; 6-[(3R)-4-[6-(4-fluorophenyl)-2-[(2R)-2-methylpyrrolidin-1-yl]pyrimidin-4-yl]-3-methylpiperazin-1-yl]-5-methylpyridine-3-carboxylic acid; 6-{4-[6-(4-Fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidin-4-yl]-3-(R)-methyl-piperazin-1-yl}-5-methyl-nicotinic acid; 3-Pyridinecarboxylic acid, 6-[(3R)?-4-[6-(4-fluorophenyl)?-2-[(2R)?-2-methyl-1-pyrrolidinyl]?-4-pyrimidinyl]?-3-methyl-1-piperazinyl]?-5-methyl-; 878811-00-8 (free base); 1855897-95-8 (mesylate salt). Grades: >98%. CAS No. 878811-00-8. Molecular formula: C27H31FN6O2. Mole weight: 490.58. | |
| MK-2461 | MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met. MK-2461 inhibited in vitro phosphorylation of a peptide substrate recognized by wild-type or oncogenic c-Met kinases (N1100Y, Y1230C, Y1230H, Y1235D, and M1250T) with IC50 values of 0.4 to 2.5 nmol/L. In tumor cells, MK-2461 effectively suppressed constitutive or ligand-induced phosphorylation of the juxtamembrane domain and COOH-terminal docking site of c-Met, and its downstream signaling to the phosphoinositide 3-kinase-AKT and Ras-extracellular signal-regulated kinase pathways, without inhibiting autophosphorylation of the c-Met activation loop. In cell culture, MK-2461 inhibited hepatocyte growth factor/c-Met-dependent mitogenesis, migration, cell scatter, and tubulogenesis. In a murine xenograft model of c-Met-dependent gastric cancer, a well-tolerated oral regimen of MK-2461 administered at 100 mg/kg twice daily effectively suppressed c-Met signaling and tumor growth. Synonyms: MK 2461; MK2461; MK-2461. Grades: >98%. CAS No. 917879-39-1. Molecular formula: C24H25N5O5S. Mole weight: 495.554. | |
| MK 287 | MK-287 is platelet activating factor (PAF) inhibitor originated by Merck & Co. It can potently inhibit [3H]C18-PAF binding to human platelet, PMN (polymorphonuclear leukocyte) and lung membranes. The inhibitory effects are competitive and stereospecific. Clinical trials for asthma was discontinued. Uses: Asthma. Synonyms: MK-287; MK 287; MK287; L-680573; L 680573; L680573;2-((3-methoxy-2-propoxy-5-((2S,5S)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran-2-yl)phenyl)sulfonyl)ethan-1-ol. Grades: 98%. CAS No. 135947-75-0. Molecular formula: C25H34O9S. Mole weight: 510.60. | |
| MK-2894 | MK-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the EP4 receptor. It is found to have conceivable potency and selectivity for further study and might be safer than traditional Non-steroidal anti-inflammatory drugs and co. Uses: Mk-2894, a nonacylsulfonamide analogue, is a high affinity full antagonist against the ep4 receptor. Synonyms: MK-2894; MK 2894; MK2894; CHEMBL597997; 1006036-87-8; 4- [1- [ [2, 5-dimethyl-4- [ [4- (trifluoromethyl) phenyl] methyl] thiophene-3-carbonyl] amino] cyclopropyl] benzoicacid; C25H22F3NO3S; GTPL4041. Grades: 95%. CAS No. 1006036-87-8. Molecular formula: C25H22F3NO3S. Mole weight: 473.51. | |
| MK-2894 Na salt | The sodium salt form of MK-2894 that is found to have conceivable potency and selectivity for further study and might be safer than traditional Non-steroidal anti-inflammatory drugs and coxibs in the treatment of pain and inflammation. IC50: 2.5 nM (Ki=0. Uses: The sodium salt form of mk-2894 that is found to have conceivable potency and selectivity in the treatment of pain and inflammation. Synonyms: MK-2894 Na salt; MK 2894 Na salt; MK2894 Na salt; sodium; 4-[1-[[2, 5-dimethyl-4-[[4- (trifluoromethyl) phenyl]methyl]thiophene-3-carbonyl]amino]cyclopropyl]benzoate; MK-2894 (sodiumsalt) ; 1006036-88-9; MK-2894Nasalt; C25H21F3NO3S. Na. Grades: 95%. CAS No. 1006036-88-9. Molecular formula: C25H21F3NNaO3S. Mole weight: 495.49. | |
| MK-351 hydrochloride | MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension. It has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase. Uses: Mk-351 hydrochloride is a psychoactive drug used as a sympatholytic or antihypertensive. it plays a role in treating hypertension and gestational hypertension. Synonyms: MK-351 hydrochloride; MK 351 hydrochloride; MK351 hydrochloride; Alpha-Methyldopa hydrochloride;L-(-)-A-Methyldopa hydrochloride;Alpha-Methyldopa HCl;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;3-Hydroxy-alpha-methyl-L-tyrosine hydrochloride;L-Tyrosine, 3-hydroxy-alpha-methyl-, hydrochloride;Methyldopa hydrochloride. Grades: >98 %. CAS No. 884-39-9. Molecular formula: C10H14ClNO4. Mole weight: 247.68. | |
| MK-3697 | MK3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. MK-3697 is also the third insomnia product, currently being developed by Merck. MK-3697 has Ki = 0.95 nM. Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species. Synonyms: MK-3697; MK3697; MK 3697. Grades: 0.99. CAS No. 1224846-01-8. Molecular formula: C23H21N5O3S. Mole weight: 447.513. | |
| MK-386 | MK-386 is a human type I 5α-reductase inhibitor with selectivity for type I 5α-reductase over type II 5α-reductase (IC50 = 0.9 and 154 nM, respectively). It reduces dihydrotestosterone (DHT) in serum and sebum in a dose-dependent manner, suggesting its utilization in acne treatment. Uses: 5-alpha reductase inhibitors. Synonyms: MK 386; MK386; (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-indeno[5,4-f]quinolin-2-one. Grades: ≥98% by HPLC. CAS No. 158493-17-5. Molecular formula: C28H49NO. Mole weight: 415.69. | |
| MK-3903 | MK-3903 is a potent and selective AMPK activator with EC50 value of 8 nM. Synonyms: MK 3903; MK3903; 5-[[6-Chloro-5-(4-phenylphenyl)-1H-benzimidazol-2-yl]oxy]-2-methylbenzoic acid. CAS No. 1219737-12-8. Molecular formula: C27H19ClN2O3. Mole weight: 454.90. | |
| MK-3984 | MK-3984 is a androgen receptor modulators. It can be used for the prevention and treatment of muscle wasting associated with cancer. Uses: Muscle wasting associated with cancer. Synonyms: MK3984; MK 3984; MK-3984; (R)-3,3,3-trifluoro-N-(2-fluoro-5-(trifluoromethyl)benzyl)-2-hydroxy-2-phenylpropanamide. Grades: 98%. CAS No. 871325-55-2. Molecular formula: C17H12F7NO2. Mole weight: 395.27. | |
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