BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| MRS 4062 triethylammonium salt | MRS 4062 is a hP2Y4 agonist with EC50 value of 23 nM, EC50 value of 640 nM to P2Y2 receptor and EC50 value of 740 nM to P2Y6 receptor. Synonyms: N4-Phenylpropoxycytidine-5'-O-triphosphate tetra(triethylammonium) salt; MRS4062; MRS 4062; MRS-4062; MRS 4062 triethylammonium salt. Grades: ≥99% by HPLC. CAS No. 1309871-50-8. Molecular formula: C18H26N3O15P3.4(C2H5)3N. Mole weight: 1022.09. |  |
| MRS 5698 | MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM), with >1000-fold selectivity over A1 and A2A adenosine receptors. It is becoming an important pharmacological tool for defining A3AR effects and is orally active in a chronic neuropathic pain model. Synonyms: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide; MRS5698; MRS 5698; MRS-5698. Grades: ≥96% by HPLC. CAS No. 1377273-00-1. Molecular formula: C28H23ClF2N6O3. Mole weight: 564.97. | |
| MRT 10 | MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells. Synonyms: MRT 10; MRT10; MRT-10; N-[[[3-Benzoylamino) phenyl]amino]thioxomethyl]-3, 4, 5-trimethoxybenzamide. Grades: ≥98%. CAS No. 330829-30-6. Molecular formula: C24H23N3O5S. Mole weight: 465.52. | |
| MRT67307 HCl | MRT67307 is a potent and dual IKK? and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1 and ULK2 with IC50 value of 45 and 38nM, respectively. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 HCl; MRT-67307 HCl; MRT67307 HCl. Grades: 99.80 %. Molecular formula: C26H36N6O2ยท xHCl. Mole weight: 464.6 (free-base). | |
| MRT68921 | MRT68921 is an inhibitor of ULK1 and ULK2 with IC50 values of 2.9 and 1.1 nM, respectively. It inhibits ULK and blocks autophagy in cells. Synonyms: N- (3- ( (5-Cyclopropyl-2- ( (2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-6-yl) amino) pyrimidin-4-yl) amino) propyl) cyclobutanecarboxamide; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-. Grades: ≥98%. CAS No. 1190379-70-4. Molecular formula: C25H34N6O. Mole weight: 434.58. | |
| MRT 68921 dihydrochloride | MRT 68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It also inhibits autophagy in mouse embryonic fibroblasts. Synonyms: N- [3- [ [5-Cyclopropyl-2- [ (1, 2, 3, 4-tetrahydro-2-methyl-6-isoquinolinyl) amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:1). Grades: ≥98% by HPLC. CAS No. 2080306-21-2. Molecular formula: C25H34N6O.2HCl. Mole weight: 507.50. | |
| MRT-83 | This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83; MRT 83; MRT83; N-[5-[[imino[ (3, 4, 5-trimethoxybenzoyl) amino]methyl]amino]-2-methylphenyl]-[1, 1'-Biphenyl]-4-carboxamide; 1359944-60-7 (HCl salt). Grades: 98%. CAS No. 1263131-92-5. Molecular formula: C31H30N4O5. Mole weight: 538.59. | |
| MRT-83 hydrochloride | MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and mouse Smo. MRT-83 can efficiently antagonize Hh signaling in vivo. MRT-83 may help develop new therapies for the treatment of Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83 hydrochloride; MRT 83 hydrochloride; MRT83 hydrochloride; N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;1263131-92-5 (free base). Grades: 98%. CAS No. 1359944-60-7. Molecular formula: C31H31ClN4O5. Mole weight: 575.06. | |
| MRT-92 HCl salt | MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (IC50 value is 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs, so MRT-92 may be become a drug candidate for treatment of cancer. Uses: Cancer. Synonyms: MRT-92 HCl salt; MRT 92 HCl salt; MRT92 HCl salt; 3, 4, 5-trimethoxy-N- (N- (4-methyl-3- (4-phenethylbenzamido) phenyl) carbamimidoyl) benzamide hydrochloride. Grades: 98%. CAS No. 1428307-52-1. Molecular formula: C33H35ClN4O5. Mole weight: 603.13. | |
| MRX-2843 | MRX-2843 is a dual inhibitor of MerTK and FLT3 with IC50 values of 1.3 and 1 nM, respectively. It induces apoptosis and inhibits colony formation in AML cell lines and other tumor cells expressing MERTK and/or FLT3-ITD. Treatment with MRX-2843 significantly prolonged survival of AML mouse models. Synonyms: 4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol. Grades: ≥95%. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. | |
| MS0022 | MS0022 is a SMO antagonist. It showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. It reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. It is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo. Uses: Ms0022 is a treatment led to a transient delay of tumor growth. Synonyms: MS-0022; MS 0022; MS0022. 2-Bromo-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide. Grades: 98%. CAS No. 691392-89-9. Molecular formula: C21H16BrN3O. Mole weight: 406.28. | |
| MS-1020 | MS-1020 is a selective, cell-permeable inhibitor of Janus kinase 3 (JAK3). It potently inhibited persistently-active STAT3 in a cell type-specific manner, and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. Synonyms: MS 1020; MS1020; 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide. Grades: ≥95%. CAS No. 1255516-86-9. Molecular formula: C21H18N2O3. Mole weight: 346.4. | |
| MS 245 Oxalate | MS 245 oxalate is a 5-HT6 antagonist with high affinity (Ki = 2.1 nM). It potentiates the hypolocomotor actions of (-)-nicotine in mice. Synonyms: MS 245 oxalate; MS245 oxalate; MS-245 oxalate; 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate. Grades: ≥99% by HPLC. CAS No. 275363-58-1. Molecular formula: C21H24N2O7S. Mole weight: 448.49. | |
| MSA-2 | An orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. Grades: >98%. CAS No. 294425-81-6. Molecular formula: C14H14O5S. Mole weight: 294.32. | |
| MSAB | MSAB is a Wnt/β-catenin signaling inhibitor. It has selective and potent anti-tumor effects on Wnt-dependent cancer cells. MSAB binds to β-catenin, promotes its degradation, and specifically down-regulates Wnt/β-catenin target genes. Grades: 98%. CAS No. 173436-66-3. Molecular formula: C15H15NO4S. Mole weight: 305.4. | |
| MSB-2311 | MSB-2311 is a second-generation programmed cell death 1 ligand 1 (PD-L1) antibody with pH-dependent antigen binding property. The pH-dependent antigen binding property allows recycle of MSB-2311 in tumor cells and much longer residence time. Studies show that MSB-2311 is active in multiple tumor models. Uses: Pd-l1 antibody. Synonyms: Betifisolimab; MSB-2311; MSB 2311; MSB2311. CAS No. 2460539-60-8. | |
| MSOP | MSOP is a selective group III metabotropic glutamate receptor (mGluR) antagonist. MSOP exhibits an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. MSOP has no effect on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Synonyms: (RS)-α-Methylserine-O-phosphate; Alpha-MSOP; Alpha-methylserine-O-phosphate; 2-amino-2-methyl-3-phosphonooxypropanoic acid. CAS No. 66515-29-5. Molecular formula: C4H10NO6P. Mole weight: 199.1. | |
| MSPG | MSPG is a non-selective antagonist of presynaptic mGluRs. Synonyms: (RS)-α-Methyl-4-sulfonophenylglycine; MSPG; (RS)-MSPG; 2-amino-2-(4-sulfophenyl)propanoic acid. CAS No. 169209-64-7. Molecular formula: C9H11NO5S. Mole weight: 245.25. | |
| MSX-122 | MSX-122 is a novel small molecule and partial CXCR4 antagonist. Synonyms: MSX122; MSX 122; MSX-122. N-[[4-[ (pyrimidin-2-ylamino) methyl]phenyl]methyl]pyrimidin-2-amine. CAS No. 897657-95-3. Molecular formula: C16H16N6. Mole weight: 292.34. | |
| MTEP hydrochloride | Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7, and 8) inhibit adenylyl cyclase. MTEP is a negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50=110 nM). MTEP at 0.3 mg/kg produces antidepressant effects in several rodent models of depression. It also demonstrates neuroprotective potential by preventing excitotoxic neuronal damage when administered through either intrahippocampal or intraperitoneal injection. Additionally, MTEP demonstrates an anxiolytic-like phenotype in rodent models similar to that of benzodiazepines while lacking undesirable sedative and addictive effects. Synonyms: 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride; MTEP. Grades: >98%. CAS No. 1186195-60-7. Molecular formula: C11H9ClN2S. Mole weight: 236.72. | |
| mTOR-IN-1 | Selective inhibitors of mammalian target of rapamycin (mTOR) kinase based upon saturated heterocycles fused to a pyrimidine core were designed and synthesized. Each series produced compounds with Ki < 10 nM for the mTOR kinase and>500-fold selectivity over closely related PI3 kinases. This potency translated into strong pathway inhibition, as measured by phosphorylation of mTOR substrate proteins and antiproliferative activity in cell lines with a constitutively active PI3K pathway. Two compounds exhibiting suitable mouse PK were profiled in in vivo tumor models and were shown to suppress mTORC1 and mTORC2 signaling for over 12 h when dosed orally. Both compounds were additionally shown to suppress tumor growth in vivo in a PC3 prostate cancer model over a 14 day study. Synonyms: mTOR-IN-1; mTOR IN 1. Grades: >98%. CAS No. 1207358-59-5. Molecular formula: C25H30N8O2. Mole weight: 474.56. | |
| MTX-211 | MTX-211 is a dual inhibitor of EGFR and PI3K, which plays important roles in the progression of KRAS mutant colorectal cancer. MTX-211 has the potential for the treatment of KRAS mutant colorectal cancer. Synonyms: MTX-211; MTX 211; MTX211; CS-7929; CS 7929; CS7929; HY-107364; HY 107364; HY107364; N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)pyridin-3-yl)methanesulfonamide. Grades: ≥98%. CAS No. 1952236-05-3. Molecular formula: C20H14Cl2FN5O2S. Mole weight: 478.323. | |
| Muraglitazar | Muraglitazar is a peroxisome proliferator-activated receptor (PPAR) α/γ dual agonist(EC50s = 320 and 110 nM in vitro). Uses: A peroxisome proliferator-activated receptor (ppar) α/γ dual agonist. Synonyms: Pargluva; BMS 298585; BMS-298585; BMS298585; Muraglitazar; N- ( (4-methoxyphenoxy) carbonyl) -N- ( (4- (2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy) phenyl) methyl) glycine; Muraglitazar; N-[ (4-Methoxyphenoxy) carbonyl]-N-[[4-[2- (5-methyl-2-phenyl-4-oxazolyl) ethoxy]phenyl]methyl]glycine; Pargluva. Grades: ≥98%. CAS No. 331741-94-7. Molecular formula: C29H28N2O7. Mole weight: 516.54. | |
| Muristerone A | Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. It is an agonist of the ecdysteroid receptor (Kd = 1 nM), a nuclear receptor that heterodimerizes with a retinoid X receptor ortholog and regulates arthropod development. Muristerone A stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells. Synonyms: (2β, 3β, 5β, 11α, 22R)-2, 3, 5, 11, 14, 20, 22-Heptahydroxycholest-7-en-6-one; Mur A. Grades: ≥97% by HPLC. CAS No. 38778-30-2. Molecular formula: C27H44O8. Mole weight: 496.63. | |
| (+)-Muscarine iodide | (+)-Muscarine iodide is a muscarinic receptor agonist with activity similar to that of acetylcholine, involved in the production of gastric acid. Synonyms: 2,5-Anhydro-1,4,6-trideoxy-6-(trimethylammonio)-D-ribo-hexitol iodide. CAS No. 24570-49-8. Molecular formula: C9H20INO2. Mole weight: 301.17. | |
| MUT056399 | MUT056399 is an antibacterial especially against S. aureus and E. coli. It has not been reporte a clinical trial after presenting the preclinical trial data in 2012 yet. IC50: 12 nM and 58 nM for S. aureus and E. coli respectively. Uses: Mut056399 is an antibacterial especially against s. aureus and e. coli. Synonyms: UNII-B52RPV7VRM; MUT056399; B52RPV7VRM; CHEMBL2178284; FAB001; SCHEMBL1498707. Grades: 98%. CAS No. 1269055-85-7. Molecular formula: C15H13F2NO3. Mole weight: 293.27. | |
| Mutant IDH1-IN-1 | Mutant IDH1-IN-1, a mutant IDH1 R132H inhibitor, could be used in some biological studies. Uses: Mutant idh1-in-1 is a mutant idh1 r132h inhibitor that could be used in some biological studies. Synonyms: Mutant IDH1-IN-1; 1355326-21-4; MutantIDH1-IN-1; IDH1-IN-1; SCHEMBL15118896; C30H31FN4O2. Grades: 98%. CAS No. 1355326-21-4. Molecular formula: C30H31FN4O2. Mole weight: 498.59. | |
| Mutant IDH1-IN-2 | Mutant IDH1-IN-2, aslo called as SCHEMBL14831158, is an inhibitor of mutant IDH protein. It is developed for the treatment of diseases associated with such mutant IDH proteins, such as cancer. Synonyms: (4S) -3-[2-[[ (1S) -1-[4-[ (4, 4-difluoropiperidin-1-yl) methyl]phenyl]ethyl]amino]pyrimidin-4-yl]-4-propan-2-yl-1, 3-oxazolidin-2-oneMutant IDH1-IN-2 SCHEMBL14831158 BDBM146172 CS-5119 HY-18717 US8957068, 224 (S)-3-(2-(((S)-1-(4-((4,4-difluoropiperidin-1-yl)met. CAS No. 1429176-69-1. Molecular formula: C24H31F2N5O2. Mole weight: 459.53. | |
| MX69 | MX69 inhibits expression of both MDM2 and XIAP, used for cancer treatment. MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. Synonyms: 4-(8-(N-(2,3-dimethylphenyl)sulfamoyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-4-yl)benzoic acid; MX69; MX-69; MX 69. CAS No. 1005264-47-0. Molecular formula: C27H26N2O4S. Mole weight: 474.57. | |
| MY-5445 | MY-5445 is a specific inhibitor of cyclic GMP phosphodiesterase, selective for PDE5, with a Ki value of 1.3 μM. It inhibits calcium- and cAMP-selective PDEs with Ki values of >1,000 and 915 μM, respectively. Synonyms: MY 5445; MY5445; MY-5445; 1-(3-Chlorophenylamino)-4-phenylphthalazine. CAS No. 78351-75-4. Molecular formula: C20H14ClN3. Mole weight: 331.8. | |
| (-)-N 0425 hydrochloride | (-)-N 0425 hydrochloride is a potent monoamine oxidase (MAO) inhibitor. Synonyms: N 0425 hydrochloride; N0425 hydrochloride; N-0425 hydrochloride. Grades: 99%. CAS No. 98640-73-4. Molecular formula: C14H17N.HCl. Mole weight: 235.75. | |
| N 0425 hydrochloride | N 0425 hydrochloride is a potent monoamine oxidase (MAO) inhibitor. Synonyms: N 0425 hydrochloride; N0425 hydrochloride; N-0425 hydrochloride; N-methyl-N-prop-2-ynyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride. Grades: 99%. CAS No. 78621-26-8. Molecular formula: C14H17N.HCl. Mole weight: 235.75. | |
| N 0426 hydrochloride | N 0426 hydrochloride is a dopamine receptor agonist. Synonyms: N 0426 hydrochloride; N0426 hydrochloride; N-0426 hydrochloride; 7-[methyl(prop-2-ynyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride. Grades: 98%. CAS No. 150542-92-0. Molecular formula: C14H17NO.HCl. Mole weight: 251.75. | |
| N 0430 hydrobromide | N 0430 hydrobromide is a monoamine oxidase (MAO) inhibitor and a dopamine agonist. Synonyms: N 0430 hydrobromide; N0430 hydrobromide; N-0430 hydrobromide; 6-[methyl(prop-2-ynyl)amino]-5,6,7,8-tetrahydronaphthalene-1,2-diol hydrobromide. Grades: 99%. CAS No. 96333-04-9. Molecular formula: C14H17NO2.HBr. Mole weight: 312.2. | |
| N 0432 hydrobromide | N 0432 hydrobromide is a monoamine oxidase (MAO) inhibitor and a dopamine agonist. Synonyms: N 0432 hydrobromide; N0432 hydrobromide; N-0432 hydrobromide; 6-[methyl(prop-2-ynyl)amino]-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide. Grades: 96%. CAS No. 96333-05-0. Molecular formula: C14H17NO2.HBr. Mole weight: 312.2. | |
| N 0734 hydrochloride | N 0734 hydrochloride is a potent and selective dopamine (DA) receptor agonist. Synonyms: N 0734 hydrochloride; N0734 hydrochloride; N-0734 hydrochloride; 6-[propyl(2-thiophen-3-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol hydrochloride. Grades: 99%. CAS No. 102121-01-7. Molecular formula: C19H25NOS.HCl. Mole weight: 351.93. | |
| N-0861 racemate | N-0861 racemate is the racemate of N-0861 which appears to be an effective and selective A1 adenosine receptor antagonist in humans. Synonyms: N-0861 racemate; N 0861 racemate; N0861 racemate; N-(3-bicyclo[2.2.1]heptanyl)-9-methylpurin-6-amine; N-0861 (racemate). CAS No. 121241-87-0. Molecular formula: C13H17N5. Mole weight: 243.31. | |
| N20C hydrochloride | N20C hydrochloride is an NMDA receptor antagonist with an IC50 of 5 μM. It shows neuroprotective activity in vivo. Synonyms: Acetamide, 2-[(3,3-diphenylpropyl)amino]-, hydrochloride (1:1); N 20C hydrochloride; N-20C hydrochloride; 2-(3,3-Diphenyl-propylamino)-acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1177583-87-7. Molecular formula: C17H20N2O.HCl. Mole weight: 304.82. | |
| N-[2-(4-Aminophenyl)ethyl]-adenosine | N6-[2-(4-Aminophenyl)ethyl]adenosine is a potent, non-selective adenosine A3 adenosine receptor agonist. It could enhance the protective activity of carbamazepine and the protective activity potentiates most likely through the A subtype of adenosine receptors at low doses. It also enhances the anticonvulsive effect of other antiepileptics via adenosine A1 receptors at higher doses. It has no significant effect on seizure parameters in amygdala-kindled rats in vivo. It is combined with antiepileptic drugs administered at doses ineffective in fully kindled rats. Uses: N6-[2-(4-aminophenyl)ethyl]adenosine could enhance the protective activity of carbamazepine. it also enhances the anticonvulsive effect of other antiepileptic. Synonyms: APNEA;Adenosine, N6-2-(4-aminophenyl)ethyl;(2R,3R,4S,5R)-2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol. Grades: >98%. CAS No. 89705-21-5. Molecular formula: C18H22N6O4. Mole weight: 386.41. | |
| N-(2-Chloroethyl)dibenzylamine hydrochloride | Dibenamine is an irreversible blocker of α1 adrenoceptors. Synonyms: N,N-dibenzyl-2-chloroethanamine;hydrochloride. CAS No. 55-43-6. Molecular formula: C16H19Cl2N. Mole weight: 296.23. | |
| N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide | N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide is a selective ligand belongs to benzamides, therapeutic agents for human prostate tumors sigma-1, which binds with high affinity to human malignant melanoma cells A2058. CAS No. 155054-42-5. Molecular formula: C14H19IN2O. Mole weight: 358.22. | |
| N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide | TAPI 2 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor (Ki = 120 nM at ADAM-17). TAPI 2 sensitizes cancer stem cells to the lethal effects of 5-FU in vitro, and inhibits shedding of TNF-α from cell membranes. Synonyms: TAPI 2; TAPI2; TAPI-2; N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide; Immunex compound 1. Grades: ≥95% by HPLC. CAS No. 689284-12-6. Molecular formula: C19H37N5O5. Mole weight: 415.54. | |
| N-[(4-Aminophenyl)methyl]adenosine | N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor with Ki value of 29 nM for Rat ecto-5'-Nucleotidase. Synonyms: 4-Abza; 4Abza; 4 Abza; 4-ABzA; 4ABzA; 4 ABzA; N(6)-(4-aminobenzyl)adenosine; N6-[(P-Aminobenzyl)adenosine. Grades: >98 %. CAS No. 95523-13-0. Molecular formula: C17H20N6O4. Mole weight: 372.37. | |
| N-5-Carboxypentyl-1-deoxynojirimycin | N-5-Carboxypentyl-1-deoxynojirimycin is a ligand used for the purification of glucosidase I and II. It can act as an inhibitor of glucosidase. Synonyms: N-5-Carboxypentyl-1-dNM; 6-[(2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidin-1-yl]hexanoic acid. Grades: ≥95%. CAS No. 79206-51-2. Molecular formula: C12H23NO6. Mole weight: 277.3. | |
| N6-Cyclohexyladenosine | N6-Cyclohexyladenosine is a derivative of Adenosine, a selective A1 receptor agonist with EC50 = 8.2 nM. Uses: A1 receptor enhancer. Synonyms: Cyclohexyladenosine; N-Cyclohexyladenosine; (2R,3R,4S,5R)-2-[6-(cyclohexylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol. Grades: ≥99%. CAS No. 36396-99-3. Molecular formula: C16H23N5O4. Mole weight: 349.38. | |
| N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate | N-(8Z-Heptadecen-1-yl)-O-(3-pyridylmethyl)carbamate acts as an inhibitor of fatty acid amide hydrolase (FAAH). It decreased cell viability of non-small lung cancer cells A549 and H460 with IC50 of 4.9 and 0.9 μM, respectively. Synonyms: Pyridin-3-ylmethyl N-[(Z)-heptadec-8-enyl]carbamate. Grades: ≥98%. CAS No. 1450603-63-0. Molecular formula: C24H40N2O2. Mole weight: 388.6. | |
| N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide | N-Acetyl-O-phosphono-Tyr-Glu Dipentylamide is a phosphopeptide ligand for the src SH2 domain. It was used in the study of potent dipeptide inhibitors of the pp60c-src SH2 domain. Synonyms: N-Acetyl-O-phosphono-L-tyrosyl-N,N-dipentyl-L-α-glutamine. CAS No. 190078-50-3. Molecular formula: C26H42N3O9P. Mole weight: 571.61. | |
| N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu | N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu is a phosphopeptide ligand for the src SH2 domain with IC50 value of 1 μM. It blocks src interactions with EGFR and FAK. Synonyms: N-Acetyl-O-phosphono-L-tyrosyl-L-α-glutamyl-L-α-glutamyl]-L-α-glutamyl-L-isoleucyl]-L-glutamic acid. CAS No. 159439-02-8. Molecular formula: C32H46N5O17P. Mole weight: 803.71. | |
| N-Acetylpuromycin | N-Acetylpuromycin is a selective CB2 receptor agonist. It downregulates Ski protein and SnoN expression, but promotes TGF-β signaling independently of MAPK activation. It does not block protein synthesis or bind to ribosomes. Synonyms: N-Acetylpurinomycin; N Acetylpurinomycin; 3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine; 3'-(L-α-Acetamido-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine. Grades: ≥98% by HPLC. CAS No. 22852-13-7. Molecular formula: C24H31N7O6. Mole weight: 513.55. | |
| N-Acetylserotonin | Cas No. 1210-83-9. | |
| N-Acetyltryptamine | N-Acetyltryptamine is a structural analog of 5-methoxy-N-acetyltryptamine which acts as a melatonin receptor antagonist in chicken retina and frog skin, and as a partial agonist in rabbit retina. It is a reaction product of assays for serotonin N-acetyltransferase and is used for determination of serotonin N-acetyl transferase. It binds to the melatonin MT2 receptor with Ki value of 41 nM. Synonyms: N-[2-(1H-indol-3-yl)ethyl]-acetamide; 3-(2-N-Acetylaminoethyl)indole. Grades: ≥99% by HPLC. CAS No. 1016-47-3. Molecular formula: C12H14N2O. Mole weight: 202.26. | |
| nAChR agonist CMPI hydrochloride | nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity. CAS No. 2250025-94-4. Molecular formula: C18H20Cl2N4O. Mole weight: 379.28. | |
| NAD 299 hydrochloride | NAD 299 hydrochloride is a 5-HT1A receptor antagonist. It can be used in psychotropic drug development. Synonyms: NAD-299 HCl; NAD 299 HCl; NAD299 HCl; NAD-299 hydrochloride; NAD 299 Hydrochloride; NAD299 Hydrochloride; (3R)-3-(Dicyclobutylamino)-8-fluoro-3,4-dihydro-2H-1-benzopyran-5-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 184674-99-5. Molecular formula: C18H23FN2O2.HCl. Mole weight: 354.85. | |
| Nafadotride | Nafadotride inhibits potently and stereoselectively [125I]iodosulpride binding at recombinant human dopamine D3 receptors. Ki values are 0.52, 5, and 269 nM for human cloned D3, D2 and D4 receptors respectively. Uses: Dopamine antagonists. Synonyms: N-[(1-Butyl-2-pyrrolidinyl)methyl]-4-cyano-1-methoxy-2-naphthalenecarboxamide. Grades: ≥98% by HPLC. CAS No. 149649-22-9. Molecular formula: C22H27N3O2. Mole weight: 365.47. | |
| Nafamostat | Nafamostat is a broad spectrum serine protease inhibitor and kallikrein inhibitor. It inhibits blood coagulation and used as an anticoagulant. It is also a possible complement inhibitor. It is mainly used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. It is formulated with HCl salt due to its basic tendencies. Uses: Nafamostat inhibits blood coagulation and used as an anticoagulant. it is also a possible complement inhibitor. it is mainly used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Synonyms: FUT-175; FUT 175; FUT175; 6-Amidino-2-naphthyl 4-guanidinobenzoate;(6-carbamimidoylnaphthalen-2-yl) 4-(diaminomethylideneamino)benzoate; Benzoic acid,4-[(aminoiminomethyl)amino]-, 6-(aminoiminomethyl)-2-naphthalenyl ester. Grades: 95%. CAS No. 81525-10-2. Molecular formula: C19H17N5O2. Mole weight: 347.37. | |
| Nafamostat hydrochloride | Nafamostat hydrochloride is a synthetic serine protease inhibitor. It is used as an anticoagulant. It is similar to Tranilast. Uses: Nafamostat hydrochloride is used as an anticoagulant. Synonyms: Benzoic acid,4-[(aminoiminomethyl)amino]-,6- (aminoiminomethyl)-2-naphthalenyl ester,dihydrochloride;Nafamostat mesylate dihydrochloride;6-Amidino-2-naphthyl p-guanidinobenzoate dimethanesulfonate dihydrochloride. Grades: >98%. CAS No. 80251-32-7. Molecular formula: C19H19N5O2Cl2. Mole weight: 420.29. | |
| Nafcillin | Nafcillin, a semi-synthetic penicillin analogue, has been found to be an antibiotic that could be effective especially against Gram-positive bacteria. Synonyms: Nafcillin; Naphcillin; Nafcilina; Nafcilline; Nafcillinum; Nallpen; (2S,5R,6R)-6-[(2-ethoxynaphthalene-1-carbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Grades: 98%. CAS No. 147-52-4. Molecular formula: C21H22N2O5S. Mole weight: 414.48. | |
| Nafoxidine | Nafoxidine, a triphenylethylene nonsteroidal agent, is a partial estrogen antagonist. Uses: Antineoplastic agents, hormonal. Synonyms: 1-(2-(p-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthyl)phenoxy)ethyl)pyrrolidine; 5-20-01-00210 (Beilstein Handbook Reference); BRN 1440873; BRN1440873; BRN-1440873; Nafoxidina; Nafoxidina [INN-Spanish]; Nafoxidine; Nafoxidinum; Nafoxidinum [INN-Latin]; NSC 70735; NSC70735; NSC-70735; UNII-4RIY10WM82. Grades: >98%. CAS No. 1845-11-0. Molecular formula: C29H31NO2. Mole weight: 425.56. | |
| Nafronyl oxalate | Naftidrofuryl, being useful in enhancing cellular oxidative, could be used as a vasodilator in the treatment of peripheral and cerebral vascular disorders. Uses: Naftidrofuryl could be used as a vasodilator against peripheral and cerebral vascular disorders. Synonyms: Nafronyl oxalate; 3200-06-4; 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate oxalate; Naftidrofuryl oxalate; Naftidrofuryl (oxalate); Dubimax. Grades: 98%. CAS No. 3200-6-4. Molecular formula: C26H35NO7. Mole weight: 473.56. | |
| Naftalofos | Naftalofos, an isoquinolin derivative, has been found to be an insecticide and commonly used in sheep. Synonyms: Naftalofos; Naphthalophos; Phtalophos; Maretin; Rametin; Rawetin; (1,3-dioxobenzo[de]isoquinolin-2-yl) diethyl phosphate. Grades: 98%. CAS No. 1491-41-4. Molecular formula: C16H16NO6P. Mole weight: 349.28. | |
| Naftopidil hydrochloride | Naftopidil hydrochloride is an α1-adrenoceptor antagonist with only weak antagonism at post-junctional α2 receptors. Used as a potent, persistent antihypertensive and vasodilator. Clinical formulations of naftopidil are used in the treatment of benign prostatic hyperplasia in Japan. Naftopidil also exhibits antiproliferative activity, inhibiting the growth of androgen-sensitive LNcaP cells and androgen-insensitive PC-3 cancer cell lines with IC50 values of 22.2 and 33.2 μM, respectively. Synonyms: 4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1164469-60-6. Molecular formula: C24H28N2O3.HCl. Mole weight: 428.96. | |
| Naloxonazine dihydrochloride | Naloxonazine dihydrochloride is a potent and selective antagonist for μ1 opioid receptors. Studies show that pretreatment with naloxonazine significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels. Synonyms: Bis-[5-α-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)-morphinan-6-ylidene] hydrazine dihydrochloride; Naloxonazine Dihydrochloride; Naloxonazine 2HCl. Grades: ≥98% by HPLC. CAS No. 880759-65-9. Molecular formula: C38H42N4O6.2HCl. Mole weight: 723.69. | |
| Nα-Methylhistamine dihydrochloride | Nα-Methylhistamine dihydrochloride, a production of Nα-Methylhistamine (NAMH), is a potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Nα-Methylhistamine is a potent H2R agonist as well as a H3R agonist. Synonyms: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride; 2-(1H-Imidazol-5-yl)-N-methylethanamine Dihydrochloride; 4-[2-(Methylamino)ethyl]-imidazole Dihydrochloride; N-Methyl-1H-imidazole-4-ethanamine Dihydrochloride; NAMH dihydrochloride. CAS No. 16503-22-3. Molecular formula: C6H11N3.2HCl. Mole weight: 198.09. | |
| Naltriben mesylate | Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki= 0.013, 19 and 152 nM for δ, μ and κ receptors respectively). Synonyms: 17-(Cyclopropylmethyl)-6,7-didehydro-3,14β-dihydroxy-4,5α-epoxy-6,7-2',3'-benzo[b]furanomorphinan mesylate. CAS No. 122517-78-6. Molecular formula: C26H25NO4.CH3SO3H. Mole weight: 511.59. | |
| Naluzotan | Naluzotan is a selective 5-HT1A receptor partial agonist under the development of EPIX Pharmaceuticals. It is a serotonergic drug for the treatment of generalized anxiety disorder and major depressive disorder. Uses: Generalized anxiety disorder; major depressive disorder. Synonyms: PRX-00023; PRX 00023; PRX00023; Naluzotan; N- (3- (4- (4- ( (cyclohexylmethyl) sulfonamido) butyl) piperazin-1-yl) phenyl) acetamide. Grades: 98%. CAS No. 740873-06-7. Molecular formula: C23H38N4O3S. Mole weight: 450.64. | |
| Naminidil | Naminidil is an ATP-Sensitive Potassium Channel Vasodilator used for the treatment of Alopecia. Synonyms: 1-cyano-3-(4-cyanophenyl)-2-[(2R)-3,3-dimethylbutan-2-yl]guanidine; Naminidil; UNII-7K50VT05OD. Grades: >98%. CAS No. 220641-11-2. Molecular formula: C15H19N5. Mole weight: 269.35. | |
| Nampt-IN-1 | Nampt-IN-1, a pyridyloxyacetyl tetrahydroisoquinoline compound, is a novel inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) with the potential to treat cancer. IC50: NCI-H1155 cell= 18 nM, Calu-6 cell= 49 nM, HCC1937 cell= 333 nM, MCF-7 cell= 3. Synonyms: Nampt-IN-1; Nampt-IN 1; Nampt-IN1; LSN3154567; LSN-3154567; LSN 3154567; 2-hydroxy-2-methyl-N-[2-(2-pyridin-3-yloxyacetyl)-3,4-dihydro-1H-isoquinolin-6-yl]propane-1-sulfonamideNampt-IN-1CHEMBL3586462SCHEMBL16634738. CAS No. 1698878-14-6. Molecular formula: C20H25N3O5S. Mole weight: 419.49. | |
| NAN-190 hydrobromide | The hydrobromide salt form of NAN-190 which is an effective antagonist of 5-HT1A serotonin receptor. Uses: The hydrobromide salt form of nan-190 which is an effective antagonist of 5-ht1a serotonin receptor. Synonyms: NAN-190 hydrobromide; NAN 190 hydrobromide; NAN190 hydrobromide; 2-(4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl)isoindoline-1,3-dione hydrobromide; NAN-190; Nan 190. Grades: 98%. CAS No. 115338-32-4. Molecular formula: C23H27N3O3.BrH. Mole weight: 474.40. | |
| Naphazoline hydrochloride | Naphazoline hydrochloride is an ocular vasoconstrictor used in eye drops. Uses: An ocular vasoconstrictor. Synonyms: 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole;hydrochloride. Grades: ≥95%. CAS No. 550-99-2. Molecular formula: C14H14N2.HCl. Mole weight: 246.74. | |
| Naphthoquine phosphate | Naphthoquine phosphate and artemisinine are two antimalarials developed in China. Both drugs have proven to be efficacious and well tolerated as monotherapy as well as in combination in patients suffering from malaria. The Co-naphthoquine, a novel antimalarial combination, is an oral fixed combination tablet of the naphthoquine phosphate and artemisinine. Artemisinin is characterised by a rapid onset of schizonticidal action and a short half-life. Parasite clearance is, however, often incomplete when it is employed as a single agent unless high dosages are used over several days, but such a regimen may reduce patient compliance and increase the danger of toxicity. Naphthoquine phosphate, by contrast, has a slower onset of action and a longer half-life, associated with a low recrudescence rate. Synonyms: 1-Naphthalenol, 4-[(7-chloro-4-quinolinyl)amino]-2-[[(1,1-dimethylethyl)amino]methyl]-5,6,7,8-tetrahydro-, phosphate (1:2) (salt); 2-((tert-butylamino)methyl)-4-((7-chloroquinolin-4-yl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol bis(phosphate); Naphthoquine diphosphate. Grades: >98%. CAS No. 173531-58-3. Molecular formula: C24H34ClN3O9P2. Mole weight: 605.94. | |
Our database is helping our users find suppliers everyday.
