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Fmoc-Sar-Sar-OH is a peptide building block used in solid-phase peptide synthesis. It features an Fmoc (Fluorenylmethyloxycarbonyl) protective group on the N-terminus, which shields the amino group during peptide assembly. The core structure includes two Sar (Sarcosine) residues, a small, non-polar amino acid with a methyl group replacing one hydrogen, contributing to the peptide's flexibility and hydrophobic interactions. The -OH at the C-terminus indicates a free carboxyl group, allowing for further coupling with other amino acids. This compound is utilized to introduce specific dipeptide sequences into larger peptides, influencing their structure and function. Synonyms: Fmoc-Sar-Sar; N-(Fluorenylmethoxycarbonyl)-sarcosyl-sarcosine; N-(N-(((9H-Fluoren-9-yl)methoxy)carbonyl)-N-methylglycyl)-N-methylglycine; 2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-N-methylacetamido)acetic acid; N-Fmoc-sarcosyl-sarcosine. Grade: ≥95% by HPLC. CAS No. 2313534-20-0. Molecular formula: C21H22N2O5. Mole weight: 382.42.
Fmoc-Sar-Sar-Sar-OH
Fmoc-Sar-Sar-Sar-OH is a protected tripeptide used in peptide synthesis. The Fmoc (9-Fluorenylmethoxycarbonyl) group protects the N-terminus of the first sarcosine (Sar) residue, preventing it from reacting during synthesis. Sarcosine is a non-natural amino acid known for its small size and flexibility. The remaining Sar residues in the sequence are also sarcosines, with all the side chains protected to avoid unwanted reactions. The -OH at the C-terminus indicates a free carboxyl group, allowing for further peptide coupling or modifications. This peptide is utilized for incorporating multiple sarcosine residues into peptides, with specific protections to ensure controlled and efficient synthesis. Synonyms: N-(Fluorenylmethoxycarbonyl)-sarcosyl-sarcosyl-sarcosine; 1-(9H-Fluoren-9-yl)-4,7,10-trimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazadodecan-12-oic acid; Fmoc-Sarcosyl-Sarcosyl-Sarcosine; Fmoc-Sar-Sar-Sar; N-Fmoc-Sarcosyl-Sarcosyl-Sarcosine; Fmoc-tris-Sarcosine; N-alpha-(9-Fluorenylmethyloxycarbonyl)-sarcosinyl-sarcosinyl-sarcosine. Grade: ≥95%. CAS No. 2749824-37-9. Molecular formula: C24H27N3O6. Mole weight: 453.49.
Fmoc-Sar-Sar-Sar-Sar-OH
Fmoc-Sar-Sar-Sar-Sar-OH is a protected tetrapeptide consisting of four sarcosine (Sar) residues, a non-chiral derivative of glycine with a methyl group attached to the nitrogen atom. The Fmoc (Fluorenylmethyloxycarbonyl) group protects the N-terminus of the first sarcosine residue, which can be removed under mild basic conditions during peptide synthesis. The C-terminus of the last sarcosine residue is free, indicated by -OH, allowing it to participate in further coupling reactions or modifications. This tetrapeptide can be used to introduce flexibility and alter the conformational properties of peptide chains while maintaining the overall sequence's chemical stability. Synonyms: 1-(9H-Fluoren-9-yl)-4,7,10,13-tetramethyl-3,6,9,12-tetraoxo-2-oxa-4,7,10,13-tetraazapentadecan-15-oic acid; Fmoc-Sar-Sar-Sar-Sar. Grade: ≥95%. Molecular formula: C27H32N4O7. Mole weight: 524.57.
This unusal amino acid derivative can be used as lysine or arginine mimetic. Synonyms: Fmoc-L-Cys(Boc-3-aminopropyl)-OH; (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propylsulfanyl]propanoic acid. Grade: ≥ 98% (HPLC). CAS No. 173963-91-2. Molecular formula: C26H32N2O6S. Mole weight: 500.62.
Fmoc-Ser(OtBu)-Asp(OtBu)-Tyr(OtBu)-Ser(OtBu)-OH is a protected tetrapeptide used in peptide synthesis. The Fmoc (Fluorenylmethyloxycarbonyl) group protects the N-terminus of the first serine (Ser) residue, preventing it from participating in premature reactions. The side chains of serine (Ser), aspartic acid (Asp), and tyrosine (Tyr) residues are protected by OtBu (tert-butyl) groups, which shield the hydroxyl and carboxyl groups during the synthesis process. The final Ser residue has a free carboxyl group at the C-terminus, indicated by -OH, which allows for further coupling or modifications. This peptide is designed to incorporate serine, aspartic acid, and tyrosine into peptide chains, with the protective groups ensuring precise and efficient synthesis. Synonyms: SDYS; N-((S)-2-((S)-2-((S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)propanamido)-4-(tert-butoxy)-4-oxobutanamido)-3-(4-(tert-butoxy)phenyl)propanoyl)-O-(tert-butyl)-L-serine; Fmoc-Ser(tBu)-Asp(tBu)-Tyr(tBu)-Ser(tBu)-OH. Grade: ≥97%. Molecular formula: C50H68N4O12. Mole weight: 917.11.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
Fmoc-Ser(tBu)-Aib-OH
Fmoc-Ser(tBu)-Aib-OH is commonly used in solid-phase peptide synthesis (SPPS) as a building block for peptide chains. CAS No. 135875-33-1. Molecular formula: C26H32N2O6. Mole weight: 468.55.
Fmoc-Ser(tBu)-Alko-PEG Resin
Wang resins are the standard supports for the preparation of peptide acids by the Fmoc batch solid phase synthesis strategy. Fmoc amino acids are pre-loaded to Wang resins so that that epimerization and dipeptide formation are minimized. Synonyms: Fmoc-Ser(tBu)-Wang-PEG Resin; N-α-(9-Fluorenylmethoxycarbonyl)-O-(t-butyl)-L-serine p-methoxybenzyl alcohol polyethyleneglycol resin.
Fmoc-Ser(tBu)-Ser[Psi(Me,Me)Pro]-OH is used as a reactant in the synthesis of peptides and proteins. Synonyms: Fmoc-Ser(tBu)-Ser[Ψ(Me,Me)Pro]-OH; (S)-3-[Nα-(9-Fluorenylmethyloxycarbonyl)-O-tert-butyl-L-serinyl]-2,2-dimethyloxazolidine-4-carboxylic acid; Fmoc-Ser(Tbu)-Ser(Psime,Mepro)-OH; (4S)-3-[(2S)-3-(tert-butoxy)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-2,2-dimethyl-1,3-oxazolidine-4-carboxylic acid; Fmoc-L-Ser(tBu)-L-Ser(Psi(Me,Me)pro)-OH; (S)-3-((S)-2-(((E)-((9H-fluoren-9-yl)methoxy)(hydroxy)methylene)amino)-3-(tert-butoxy)propanoyl)-2,2-dimethyloxazolidine-4-carboxylic acid. Grade: ≥ 98.5% (HPLC). CAS No. 1000164-43-1. Molecular formula: C28H34N2O7. Mole weight: 510.58.
Excellent resin for the synthesis of peptide acids using Fmoc strategy. Cleavage can be effected by 95% TFA.
Fmoc-Ser(Trt)-2-Chlorotrityl Resin
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.
2-Chlorotrityl-Chloride-Resin is less acid-labile than Trityl Resin, and is widely used for solid phase immobilization. It has been used with the Fmoc/tBu methodology in the microwave-assisted solid phase peptide synthesis.