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| Product | Description | |
|---|---|---|
| NPS-2143 | NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. Synonyms: SB-262470; NPS-2143; SB 262470; NPS 2143; SB262470; NPS2143. Grades: >98%. CAS No. 284035-33-2. Molecular formula: C24H25ClN2O2. Mole weight: 408.92. |  |
| NPS-2143 hydrochloride | NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. Synonyms: NPS2143 hydrochloride; NPS 2143 hydrochloride. Grades: >98%. CAS No. 324523-20-8. Molecular formula: C24H26Cl2N2O2. Mole weight: 445.38. | |
| NPS 2390 | NPS 2390 is a Group I mGlu antagonist. NPS 2390 acts as a noncompetitive antagonist of mGluR1 and mGluR5 with IC50 values of 5.2 and 82 nM. Synonyms: N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide. Grades: ≥99% by HPLC. CAS No. 226878-01-9. Molecular formula: C19H21N3O. Mole weight: 307.39. | |
| NPS ALX Compound 4a dihydrochloride | NPS ALX Compound 4a dihydrochloride is a 5-HT6 antagonist with IC50 value of 7.2 nM. Synonyms: 6-(Hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl)-1-(1-naphthalenylsulfonyl)-1H-indole dihydrochloride. Grades: ≥99% by HPLC. CAS No. 299433-10-6. Molecular formula: C25H25N3O2S.2HCl. Mole weight: 504.47. | |
| NPY 5RA972 | NPY5RA972 is a neuropeptide Y Y5 antagonist. Synonyms: NPY5RA972; NPY-5-RA-972; NPY 5 RA 972; N-[4-Methyl-9-(1-methylethyl)-9H-carbazol-3-yl]-4-morpholinecarboxamide. Grades: ≥98% by HPLC. CAS No. 439861-56-0. Molecular formula: C21H25N3O2. Mole weight: 351.44. | |
| NQTrp | NQTrp, also called 1,4-Naphthoquinon-2-yl-L-tryptophan, inhibits amyloid β (Aβ) oligomerization and fibrillization (IC50 = 50 nM for formation of fibrils from Aβ1-42) to treat Alzheimer's disease. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: NQTrp; NQ-Trp; NQ Trp; (2S)-2-[(1,4-dioxonaphthalen-2-yl)amino]-3-(1H-indol-3-yl)propanoic acid; 185351-19-3; nqtrp; TRY001; DTXSID30717912; ZINC100222454; KB-274843; N-(1,4-Dioxo-1,4-dihydronaphthalen-2-yl)-L-tryptophan; L-Tryptophan, N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-; NQTrp|N-(1,4-Dihydro-1,4-dioxo-2-naphthalenyl)-L-tryptophan. CAS No. 185351-19-3. Molecular formula: C21H16N2O4. Mole weight: 360.36. | |
| NRC-2694 | NRC-2694 is a small molecule antagonist of epidermal growth factor receptor (EGFR) signalling pathways, for the treatment of solid tumors. Synonyms: NRC-2694; NRC 2694; NRC2694; N-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; NRC-2694; NRC 2694; NRC2694; 4-Quinazolinamine, N-(3-ethynylphenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-. CAS No. 936446-61-6. Molecular formula: C24H26N4O3. Mole weight: 418.49. | |
| NRX-204647 | NRX-204647 is a Retinoic acid receptor gamma-selective inverse agonist. Synonyms: NRX204647; NRX-204647; NRX 204647. 4-((1E,3Z)-3-(hydroxyimino)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl)benzoic acid. Grades: 98%. CAS No. 1351452-80-6. Molecular formula: C24H27NO3. Mole weight: 377.78. | |
| NS-018 | NS-018, a selective JAK2 as well as Src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells. It is still under Phase I/II trial against Myelofibrosis. IC50: 470 nM for Ba/F3-JAK2V617F cell. Uses: Ns-018 is a selective jak2 as well as src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells. Synonyms: NS-018; NS 018; NS018; UNII-56R994WX4L; 56R994WX4L; GTPL7839; GTPL 7839; GTPL-7839; SCHEMBL14954406; UQTPDWDAYHAZNT-AWEZNQCLSA-N. Grades: 98%. CAS No. 1239358-86-1. Molecular formula: C21H20FN7. Mole weight: 389.43. | |
| NS-018 hydrochloride | The hydrochloride salt form of NS-018 which is a selective JAK2 as well as Src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells. It is still under Phase I/II trial against Myelofibrosis. IC50: 470 nM for Ba/F3-JAK2. Uses: The hydrochloride salt form of ns-018 which is a selective jak2 as well as src family tyrosine kinases inhibitor that could probably induce the apoptosis of tumor cells. Synonyms: NS018 hydrochloride; NS 018 hydrochloride. Grades: 98%. CAS No. 1239358-85-0. Molecular formula: C21H21ClFN7. Mole weight: 425.89. | |
| NS 11021 | NS 11021 is an activator of large-conductance Ca2+-activated potassium channels. It has been shown to relax intracavernous arterial rings and corpus cavernosum strips in vitro. Synonyms: NS-11021; NS 11021; NS11021. N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea. Grades: ≥98% by HPLC. CAS No. 956014-19-0. Molecular formula: C16H9BrF6N6S. Mole weight: 511.24. | |
| NS 11394 | NS 11394 is a drug with selectivity for the α3 and α5 subtypes. It acts as a subtype-selective positive allosteric modulator at GABAA receptors. It is used as an analgesic for use in chronic or neuropathic pain. It is unique in having superior efficacy at alpha(3) receptors and low efficacy at alpha(1) receptors in vitro. It has an excellent pharmacokinetic profile, which correlates with pharmacodynamic endpoints, yielding a high level of confidence in deriving in vivo conclusions anchored to an in vitro selectivity profile and allowing for translation to higher species. It impairs memory in both rats and mice because of its efficacy at GABA(A)-alpha(5) receptors. It is potent and highly effective in rodent anxiety models. It has a significantly reduced side effect profile in rat and mouse, even at full CNS receptor occupancy. Uses: Ns-11394 is used as an analgesic for use in chronic or neuropathic pain. Synonyms: NS-11394; NS 11394; NS11394; 2-[3-[5-(2-hydroxypropan-2-yl)benzimidazol-1-yl]phenyl]benzonitrile;NS-11394;3'-[5-(1-Hydroxy-1-methylethyl)-1H-benzimidazol-1-yl]-[1,1'-biphenyl]-2-carbonitrile. Grades: >98 %. CAS No. 951650-22-9. Molecular formula: C23H19N3O. Mole weight: 353.42. | |
| NS-1209 | NS-1209, an AMPA/GluR5 receptor antagonist, is a antiepileptic drug candidate currently under clinical trials. Synonyms: 2-[[5-[4-(dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-7,9-dihydro-6H-pyrrolo[3,2-h]isoquinolin-3-yl]amino]oxy-4-hydroxybutanoic acid; NS-1209; NS 1209; NS1209; 245063-59-6; SPD-502; SPD502; SPD 502. Grades: >98%. CAS No. 245063-59-6. Molecular formula: C24H28N4O7S. Mole weight: 516.57. | |
| NS 1619 | NS 1619, a benzimidazalone derivative, activates BKca channels in a number of tissues. However, the effect of NS 1619 was dependent upon the presence of Ca 2+ ions at the intracellular surface, for at free Ca2+ ion concentrations of 0.1/zM and below (a ra. Synonyms: 3-[2-hydroxy-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1H-benzimidazol-2-oneNS 1619; NS1619153587-01-0NS-16191-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-oneCHEMBL384903. Grades: >98 %. CAS No. 153587-01-0. Molecular formula: C15H8F6N2O2. Mole weight: 362.23. | |
| NS 1643 | NS 1643 is human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM). Uses: Kv11.1 channel activator. Synonyms: NS-1643; NS 1643; NS1643. 1,3-Bis(2-hydroxy-5-trifluoromethylphenyl)urea;N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea. Grades: ≥98 %. CAS No. 448895-37-2. Molecular formula: C15H10F6N2O3. Mole weight: 380.06. | |
| NS 1738 | NS 1738 is an allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). It shows cognitive-enhancing properties in vivo. Synonyms: NS1738; NS 1738; NS-1738; N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea. Grades: ≥99% by HPLC. CAS No. 501684-93-1. Molecular formula: C14H9Cl2F3N2O2. Mole weight: 365.13. | |
| NS 19504 | NS 19504 is an activator of large-conductance Ca2+-activated potassium channels. It has relaxing effects on bladder smooth muscle. Synonyms: NS 19504; NS19504; NS-19504; 5-[(4-Bromophenyl)methyl]-2-thiazolamine. Grades: ≥99% by HPLC. CAS No. 327062-46-4. Molecular formula: C10H9BrN2S. Mole weight: 269.16. | |
| NS-2359 | NS-2359, a serotonin-norepinephrine-dopamine reuptake inhibitor, may be able to reduce cocaine withdrawal symptoms, reduce cocaine craving and reduce cocaine-induced euphoria. Synonyms: (1S,3S,4R,5R)-3-(3,4-dichlorophenyl)-4-(methoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; GSK 372475; GSK-372475; GSK372475; NS 2359; NS2359; NS-2359. Grades: >98%. CAS No. 195875-68-4. Molecular formula: C16H21Cl2NO. Mole weight: 558.675. | |
| NS 30678 hydrochloride | NS 30678 hydrochloride is a dopamine D2 receptor ligand with surmountable/competitive-like D2 antagonist properties (Ki = 9.7 nM, IC50 = 7 nM, in HEK-hD2L-Gαqi5 cells). Synonyms: NS 30678 hydrochloride; NS30678 hydrochloride; NS-30678 hydrochloride. Grades: 99%. CAS No. 1193707-19-5. Molecular formula: C12H16ClNO4S.HCl. Mole weight: 342.24. | |
| NS309 | NS309 is a small- and intermediate- conductance Ca2+-activated K+ channels of SK and IK types whereas exhibits no activity at BK channels. Synonyms: 6,7-dichloro-3-(hydroxyamino)indol-2-one 6,7-dichloro-1H-indole-2,3-dione 3-oxime NS 309 NS-309 NS309 cpd. Grades: >98 %. CAS No. 18711-16-5. Molecular formula: C8H4Cl2N2O2. Mole weight: 231.04. | |
| NS 3623 | NS 3623 is a KV11.1 (hERG) and KV4.3 channel activator. It can activate the IKr and Ito currents and display antiarrhythmic activity. Synonyms: NS3623; NS 3623; NS-3623. N-[4-Bromo-2-(1H-tetrazol-5-yl-phenyl]-N'-[3-(trifluoromethyl)phenyl]-urea. Grades: ≥99% by HPLC. CAS No. 343630-41-1. Molecular formula: C15H10BrF3N6O. Mole weight: 427.18. | |
| NS 3694 | NS 3694 is an apoptosis inhibitor that inhibits the formation of the apoptosome Apaf-1 via blocking the activation of the initiator caspase 9. It does not affect apoptosome-independent caspase activation or enzymatic activity of caspases. Synonyms: NS 3694; NS3694; NS-3694; Apoptosis Inhibitor II; 4-chloro-2-[[3- (trifluoromethyl) phenyl]carbamoylamino]benzoic acid. Grades: 99%. CAS No. 426834-38-0. Molecular formula: C15H10ClF3N2O3. Mole weight: 358.7. | |
| NS 3861 | NS 3861 is an α3β2 full agonist with EC50 of 1.6 μM. It is also an α3β4 partial agonist with EC50 of 1 μM. Synonyms: NS3861; NS-3861; NS 3861; 3-(3-Bromo-2-thienyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-ene fumarate. Grades: ≥98% by HPLC. CAS No. 216853-60-0. Molecular formula: C12H14BrNS.C4H4O4. Mole weight: 400.29. | |
| NS 5806 | NS5806 is a KV4.3 channel activator. It can mediate the transient outward K+ current (Ito). Synonyms: NS-5806; NS 5806; NS5806; N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2,4-dibromo-6-(2H-tetrazol-5-yl)phenyl]urea. Grades: ≥99% by HPLC. CAS No. 426834-69-7. Molecular formula: C16H8Br2F6N6O. Mole weight: 574.07. | |
| NS6180 | NS6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively). NS6180 prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. Synonyms: NS6180; NS-6180; NS 6180. Grades: 98%. CAS No. 353262-04-1. Molecular formula: C16H12F3NOS. Mole weight: 323.33. | |
| NS-638 | NS-638 is a small nonpeptide Ca(2+)-channel blocker. Synonyms: 1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)benzimidazol-2-amine; 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole; NS 638; NS-638. CAS No. 150493-34-8. Molecular formula: C15H11ClF3N3. Mole weight: 325.72. | |
| NS 6740 | NS 6740 is an α7 nAChR partial agonist displaying anti-inflammatory activity. It reduces LPS-induced TNF-α release from microglia enriched cultures. Synonyms: 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 753499-14-8. Molecular formula: C19H19F3N2O2·HCl. Mole weight: 400.82. | |
| NS 8593 hydrochloride | NS8593 HCl is a selective KCa2 channel negative modulator. Synonyms: NS 8593 hydrochloride; NS8593 hydrochloride; NS-8593 hydrochloride; N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 875755-24-1. Molecular formula: C17H17N3.HCl. Mole weight: 299.8. | |
| NS 9283 | NS 9283 is an allosteric modulator of α4β2 receptor affecting the potency of acetylcholine related events. It can reduce the rate of recovery from desensitization and slow the rate of deactivation. Synonyms: NS9283; NS 9283; NS-9283; 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile. Grades: ≥99% by HPLC. CAS No. 913830-15-6. Molecular formula: C14H8N4O. Mole weight: 248.24. | |
| NSC 109555 dimesylate | NSC 109555 is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), displaying no effect against other kinases. It inhibits H1 phosphorylation and attenuates mitochondrial ATP synthesis. NSC 109555 can be used in cancer therapy. Synonyms: DDUG; NCI C04808; Carbanilide, 4,4'-diacetyl-, 4,4'-bis(amidinohydrazone), dimethanesulfonate. CAS No. 15427-93-7. Molecular formula: C19H24N10O·2CH3SO3H. Mole weight: 600.7. | |
| NSC 109555 ditosylate | NSC-109555 Ditosylate is an ATP-competitive Chk2 inhibitor with IC50 value of 0.2 μM. It acts by inhibiting histone H1 phosphorylation and attenuating mitochondrial ATP synthesis. It is an antileukemic agent. Synonyms: NSC-109555 Ditosylate; NSC 109555 Ditosylate; NSC109555 Ditosylate; 4,4'-diacetyldiphenylurea bis(guanylhydrazone) ditosylate. Grades: ≥98% by HPLC. CAS No. 66748-43-4. Molecular formula: C19H24N10O.2C7H8O3S. Mole weight: 752.86. | |
| NSC12 | NSC12 is an extracellular trap for fibroblast growth factor 2 (FGF2). It binds FGF2 with Kd value of 51 μM and interferes with its interaction with FGFR1 without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans. It also binds several other FGF isoforms and prevents them from forming HSPG/FGF/FGFR ternary complexes. It inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice. It inhibited the proliferation of different FGF-dependent tumour cell lines, but had no inhibitory effect on FGF-independent tumour cells expressing a constitutively active FGFR1. It was shown to inhibit FGFR phosphorylation, angiogenesis and primary and metastatic tumour growth of FGF-dependent human and mouse cancer cells in vivo. It has significant implications in cancer therapy. Uses: Nsc12 has significant implications in cancer therapy. Synonyms: NSC-12; NSC 12; NSC12; NSC 172285; NSC-172285; NSC172285; 21- (Hydroxy (bistrifluoromethyl)methyl)pregnane-3, 20-diol; Pregn-5-ene-3, 20-diol, 21-(2-hydroxy-1,1,1,3,3,3-hexafluoro-2-propyl)-;LS-118618;4,4,4-Trifluoro-1-[(8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-3-(trifluoromethyl)butane-1,3-diol;NSC-12;NSC-172285;NSC172285;(R)-4,4,4-trifluoro-1-((3S,8S,9S,10R,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-3-(trifluoromethyl)butane-1,3-diol. Grades: >98 %. CAS No. 102586-30-1. Molecular formula: C24H34F6O3. Mole weight: 484.52. | |
| NSC 228155 | NSC 228155 is an EGFR activator that binds to the dimerization domain II of sEGFR. It inhibits KIX-KID interaction with IC50 value of 0.36 μM. Synonyms: NSC228155; NSC-228155; 7-nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole. CAS No. 113104-25-9. Molecular formula: C11H6N4O4S. Mole weight: 290.25. | |
| NSC305787 | NSC305787 is a small molecule inhibitor of PKC. Its IC50 value is 8.3 μM, 9.4 μM, 55 μM for PKC&Lota; phosphorylation of recombinant ezrin, moesin and radixin. It is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. It could inhibited T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing K7M2 OS cells in this organ culture assay. It cause reduced cell motility phenotypes in zebrafish in vivo. Uses: Nsc305787 is proved a novel targeted therapy which could inhibit ezrin protein as an approach to prevent tumor metastasis in vitro. it could inhibited t567 phosphorylation and actin binding of endogenous ezrin at 10 μm without altering cellular ezrin levels and inhibit the lung metastases growth of high-ezrin-expressing k7m2 os cells in this organ culture assay. Synonyms: NSC 305787; NSC-305787; NSC 305787. Grades: >98%. CAS No. 785718-37-8. Molecular formula: C25H30Cl2N2O. Mole weight: 445.42. | |
| NSC305787 hydrochloride | NSC305787 hydrochloride is a small molecule inhibitor of PKC (IC50=8.3 μM) that directly inhibits ezrin protein as an approach to prevent tumor metastasis. Uses: A small molecule inhibitor of pkc. Synonyms: NSC-305787 Hydrochloride; NSC 305787 Hydrochloride; NSC305787 Hydrochloride; NSC-305787 HCl; NSC 305787 HCl; NSC305787 HCl; [2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride;[2-(Adamantan-1-yl)-6,8-dichloro-4-quinolinyl](2-piperidinyl)methanol hydrochloride. Grades: ≥95%. CAS No. 53868-26-1. Molecular formula: C25H31Cl3N2O. Mole weight: 481.89. | |
| NSC 319726 | NSC319726 is a p53(R175) mutant reactivator, exhibits growth inhibition in cells expressing mutant p53, with IC50 of 8 nM for p53(R175) mutant, shows no inhibition for p53 wild-type cells. Synonyms: NSC-26386; NSC-319726; NSC 26386; NSC 319726; NSC26386; NSC319726. Grades: >98%. CAS No. 71555-25-4. Molecular formula: C11H14N4S. Mole weight: 234.32. | |
| NSC 33994 | NSC-33994 is a selective inhibitor of JAK2 with IC50 of 60 nM. Synonyms: NSC-33994; NSC 33994; NSC33994; E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol. Grades: ≥98% by HPLC. CAS No. 82058-16-0. Molecular formula: C28H42N2O2. Mole weight: 438.65. | |
| NSC 3852 | NSC 3852 is a histone deacetylase inhibitor. It is shown to have cell differentiation and antiproliferative activity in human breast cancer cells. Synonyms: NSC 3852; NSC3852; NSC-3852; 5-Nitroso-8-quinolinol. Grades: ≥95% by HPLC. CAS No. 3565-26-2. Molecular formula: C9H6N2O2. Mole weight: 174.16. | |
| NSC 405020 | NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2. Synonyms: TWS119; TWS 119; TWS-119. CAS No. 7497-7-6. Molecular formula: C12H15Cl2NO. Mole weight: 260.158. | |
| NSC 42834 | A cell-permeable pyridinylbutanone compound that inhibits cellular autophosphorylation of both the wild-type Jak2 and the constitutively active V167F mutant (IC50 = 15 & 28 μM, respectively, with WT- & V617F-transfected BSC-40 cells), while exhiting no effect against cellular Tyk2 autophosphorylation in COS cells or c-Src kinase in cell-free kinase assays. Z3 suppresses the Jak2-V167F-dependent proliferation of the erythroleukemia cell line HEL by blocking the G1-S transition and is shown to effectively reduce the cytokine-stimulated growth of both Jak2-V617F-positive and Jak2-F537I-positive primary hematopoietic progenitor cells from myeloproliferative disorder patients. Synonyms: NSC 42834; NSC-42834; NSC42834; Z3; 1-Butanone, 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-. Grades: >98%. CAS No. 195371-52-9. Molecular formula: C23H24N2O. Mole weight: 344.45. | |
| NSC5844 | NSC5844 is a CCR1 agonist and a bisquinoline compound. Synonyms: N,N'-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine; NSC5844; NSC-5844; NSC 5844; RE640; RE-640; R E640. CAS No. 140926-75-6. Molecular formula: C20H16Cl2N4. Mole weight: 383.27. | |
| NSC59984 | NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. Synonyms: NSC-59984; NSC 59984. Grades: 98%. CAS No. 803647-40-7. Molecular formula: C12H15N3O4. Mole weight: 265.27. | |
| NSC 660028 | NSC 660028, an arylamino etoposide analogue, has been found to be a DNA topoisomerase II inhibitor that was once studied due to its potential anticancer activity. Synonyms: NSC660028; NSC-660028; NSC 660028; 2,6-dimethoxy-4-((5S,5aS,8aR,9R)-9-(phenylamino)-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl)phenol. Grades: 98%. CAS No. 153230-81-0. Molecular formula: C27H27NO6. Mole weight: 461.51. | |
| NSC 668036 | NSC-668036 is a Wnt signaling inhibitor, binding to the PDZ domain of the dishevelled protein. It can inhibit proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. Synonyms: NSC 668036; NSC668036; NSC-668036; N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl-(2S)-2-hydroxy-3-methylbutanoyl-L-alanine-(1S)-1-carboxy-2-methylpropyl ester. Grades: ≥98% by HPLC. CAS No. 144678-63-7. Molecular formula: C21H36N2O9. Mole weight: 460.52. | |
| NSC 66811 | NSC 66811 is a MDM2 antagonist. It can disrupt MDM2-p53 interaction. Synonyms: NSC66811; NSC-66811; NSC 66811; 2-Methyl-7-[Phenyl(phenylamino)methyl]-8-quinolinol. Grades: ≥97% by HPLC. CAS No. 6964-62-1. Molecular formula: C23H20N2O. Mole weight: 340.42. | |
| NSC 693868 | A cyclin-dependent kinases and glycogen synthase kinase-3 inhibitor with IC50 values of 0.6, 0.4 and 1 μM for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively. Synonyms: NSC 693868; NSC693868; NSC-693868; 1H-Pyrazolo[3,4-b]quinoxalin-3-amine. Grades: ≥99% by HPLC. CAS No. 40254-90-8. Molecular formula: C9H7N5. Mole weight: 185.19. | |
| NSC781406 | NSC781406 demonstrates potent PI3K inhibition (PI3Kα IC50=2.0 nM) and is a highly potent mTOR inhibitor, with reasonable liver microsome stability. Synonyms: NSC-781406; NSC 781406; NSC781406; 2,4-difluoro-N-[2-methoxy-5-[4-[3-(4-methylsulfonylpiperazin-1-yl)prop-1-ynyl]quinolin-6-yl]pyridin-3-yl]benzenesulfonamide; CHEMBL3763244; BDBM50145412. CAS No. 1676893-24-5. Molecular formula: C29H27F2N5O5S2. Mole weight: 627.68. | |
| NT113 | NT113 is a pan-ERBB inhibitor with high brain penetrance. It can inhibit the growth of glioblastoma xenografts with EGFR amplification. NT113 is active against GBM xenografts in which wild-type EGFR or EGFRvIII is highly expressed. NT113 can inhibit ERBB family member phosphorylation in vivo and vitro. It can also inhibit the phosphorylation of downstream signaling mediator Akt. No recent reports of development were identified for preclinical development in Glioblastoma in USA. Uses: Glioblastoma. Synonyms: NT-004; NT 004; NT004; NT-113; NT 113; NT113; NT-125; NT 125; NT125; (E)-N-(7-(((1R,5S,6s)-3-oxabicyclo[3.1.0]hexan-6-yl)ethynyl)-4-((3-chloro-4-fluorophenyl)amino)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grades: 98%. CAS No. 1398833-56-1. Molecular formula: C27H25ClFN5O2. Mole weight: 505.98. | |
| NT-157 | NT-157, a selective IRS-1/2 inhibitor, has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. The preclinical trails has reported by TyrNovo. IC50: 0.3 to 0.8 μM. Uses: Nt-157 is a selective irs-1/2 inhibitor that has been found to influence cell migratory at some extent and could induce the inhibition of cancer cell survival. Synonyms: NT-157; NT 157; NT157; AK174915; AK 174915; AK-174915; AKOS025404921; CS-5531; CS 5531; CS5531;(4E)-2-bromo-6-hydroxy-4-[(Z)-3-sulfanyl-3-[(3,4,5-trihydroxyphenyl)methylamino]prop-2-enylidene]cyclohexa-2,5-dien-1-one. Grades: 98%. CAS No. 1384426-12-3. Molecular formula: C16H14BrNO5S. Mole weight: 410.98. | |
| NTNCB hydrochloride | NTNCB hydrochloride is a selective, non-peptide competitive NPY Y5 antagonist (Ki= 8.0 and 16032 nM at human recombinant Y5 and Y1 receptors respectively). Synonyms: 2-Nitro-N- [ [trans-4- [ [ [ (1, 2, 3, 4-tetrahydro-2-naphthalenyl) methyl] amino] methyl] cyclohexyl] methyl] benzenesulfonamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 191931-56-3. Molecular formula: C25H33N3O4S.HCl. Mole weight: 508.07. | |
| NTR 368 | NTR 368 is a peptide fragment corresponding to residues 368-381 of the human p75 neurotrophin receptor (p75NTR). Synonyms: NTR 368; NTR368; NTR-368; (3S)-3-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-acetamidopropanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1,5-diamino-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid. CAS No. 197230-90-3. Molecular formula: C69H124N22O19. Mole weight: 1565.87. | |
| NTRC 824 | NTRC 824 is a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2 (IC50 = 38 nM), with >150-fold selectivity for NTS2 over NTS1. Synonyms: N-[2-[5-[[(4-Methylphenyl)sulfonyl]amino]-3-(2,2,2-trifluoroacetyl)-1H-indol-1-yl]acetyl]-L-leucine; NTRC-824; NTRC 824; NTRC824. Grades: ≥98% by HPLC. CAS No. 1623002-61-8. Molecular formula: C25H26F3N3O6S. Mole weight: 553.55. | |
| NU2058 | NU2058 is a potent CDK inhibitor. which has CDK2 IC(50)=17 microM and CDK1 IC(50)=26 microM. Synonyms: NU2058; NU 2058; NU-2058; O(6)-Cyclohexylmethylguanine. Grades: 0.98. CAS No. 161058-83-9. Molecular formula: C12H17N5O. Mole weight: 247.3. | |
| NU 6102 | NU 6102 is a potent inhibitor of CDK1 and CDK2 with Ki values of 9 and 6 nM and IC50 values of 9.5 and 5.4 nM, respectively. NU 6102 inhibits Cdk4 activity with IC50 value of 1.6 μM. Synonyms: NU-6102; NU6102; 4-[[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino]benzenesulfonamide. Grades: ≥95%. CAS No. 444722-95-6. Molecular formula: C18H22N6O3S. Mole weight: 402.5. | |
| NU7441 | NU7441 is a highly potent and selective DNA-PK inhibitor (IC50=14 nM), exhibiting ATP-competitive inhibition kinetics. NU7441 increased the cytotoxicity of ionizing radiation and etoposide in SW620, LoVo, and V3-YAC cells but not in V3 cells, confirming that potentiation was due to DNA-PK inhibition. NU7441 substantially retarded the repair of ionizing radiation-induced and etoposide-induced DSB. NU7441 appreciably increased G(2)-M accumulation induced by ionizing radiation, etoposide, and doxorubicin in both SW620 and LoVo cells. In mice bearing SW620 xenografts, NU7441 concentrations in the tumor necessary for chemopotentiation in vitro were maintained for at least 4 hours at nontoxic doses. NU7441 increased etoposide-induced tumor growth delay 2-fold without exacerbating etoposide toxicity to unacceptable levels. In conclusion, NU7441 shows sufficient proof of principle through in vitro and in vivo chemosensitization and radiosensitization to justify further development of DNA-PK inhibitors for clinical use. Synonyms: NU7441; NU-7441; NU 7441; KU-57788; KU 57788; KU57788. Grades: 98%. CAS No. 503468-95-9. Molecular formula: C25H19NO3S. Mole weight: 413.49. | |
| NU 9056 | NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 = < 2, 60, 36, and>100 μM for KAT5, p300, pCAF and GCN5, respectively). NU 9056 treatment inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 μM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. Also, decreased androgen receptor, prostate specific antigen, p53 and p21 protein levels were demonstrated in response to treatment with NU 9056. Synonyms: NU 9056; NU9056; NU-9056; 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole. CAS No. 1450644-28-6. Molecular formula: C6H4N2S4. Mole weight: 232.37. | |
| Nucleozin | Nucleozin is a cell-permeable isoxazolylpiperazine, which targets influenza a nucleoprotein (NP) to inhibit influenza A H1N1, H3N2 and H5N1. Synonyms: 1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine; [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone. Grades: ≥98%. CAS No. 341001-38-5. Molecular formula: C21H19ClN4O4. Mole weight: 426.85. | |
| Nuvenzepine | Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. Synonyms: 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one; 11-(N-methylisonipecotyl)-6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one; DF 545; DF-545; nuvenzepine. CAS No. 96487-37-5. Molecular formula: C19H20N4O2. Mole weight: 336.39. | |
| NVP 2 | NVP 2 is a potent, ATP-competitive CDK9 inhibitor with IC50 value of 0.5 nM, exhibiting selectivity for CDK9 over a panel of 468 kinases. Synonyms: 4- [ [ [5'-Chloro-2'- [ [trans-4- [ [ (1R) -2-methoxy-1-methylethyl]amino]cyclohexyl]amino] [2, 4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile. Grades: ≥97% by HPLC. CAS No. 1263373-43-8. Molecular formula: C27H37ClN6O2. Mole weight: 513.07. | |
| NVP-ACC789 | NVP-ACC789 is a potent, selective and orally active inhibitor of the VEGF receptor tyrosine kinases, antagonizing tumor-driven angiogenesis. Uses: A potent, selective and orally active inhibitor of the vegf receptor tyrosine kinases. Synonyms: NVP-ACC789; NVP-ACC 789; NVP-ACC-789; ACC-789; ACC 789; ACC789; ZK-202650; ZK 202650; ZK202650.AC1OCFN3;N-(3-bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine. Grades: ≥96%. CAS No. 300842-64-2. Molecular formula: C21H17BrN4. Mole weight: 405.3. | |
| NVP-AEW541 | NVP-AEW541 is a selective inhibitor of Insulin-like growth factor 1 receptor (IGF-1R) kinase. It abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. In vivo, NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas. Synonyms: AEW-541; AEW 541; AEW541; 7-[3-(azetidin-1-ylmethyl)cyclobutyl]-5-(3-phenylmethoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine. Grades: ≥98%. CAS No. 475488-34-7. Molecular formula: C27H29N5O. Mole weight: 439.6. | |
| NVP-BBD130 | NVP-BBD130 is a potent and selective dual PI3K/mTOR inhibitor. It can suppress the growth and proliferation of melanoma primary tumors and metastasis via inhibiting NVP-BEZ235 and BBD130. Uses: Antitumor agent. Synonyms: 2-methyl-2-[4-[3-methyl-2-oxo-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile. Grades: 99%. CAS No. 853910-61-9. Molecular formula: C28H21N5O. Mole weight: 443.5. | |
| NVP-BEP800 | NVP-BEP800 is a novel, fully synthetic Hsp90β inhibitor with IC50 of 58 nM, which exhibits >70-fold selectivity against Hsp90 family members Grp94 and Trap-1. Synonyms: VER82576; VER 82576; VER-82576; XL184; XL 184; XL-184; BMS-907351; BMS 907351; BMS907351; NVP BEP800; NVP-BEP 800; NVP BEP-800; BEP-800; BEP800; BEP 800. Grades: >98%. CAS No. 847559-80-2. Molecular formula: C21H23Cl2N5O2S. Mole weight: 480.41. | |
| NVP-BHG712 | NVP-BHG712 is a EphB4 kinase inhibitor and BCR-ABL inhibitor. NVP-BHG712, which inhibits EphB4 kinase activity in the low nanomolar range in cellular assays showed high selectivity for targeting the EphB4 kinase when profiled against other kinases in biochemical as well as in cell based assays. Furthermore, NVP-BHG712 shows excellent pharmacokinetic properties and potently inhibits EphB4 autophosphorylation in tissues after oral administration. In vivo, NVP-BHG712 inhibits VEGF driven vessel formation, while it has only little effects on VEGF receptor (VEGFR) activity in vitro or in cellular assays. The data shown here suggest a close cross talk between the VEGFR and EphR signaling during vessel formation. In addition to its established function in vascular remodeling and endothelial arterio-venous differentiation, EphB4 forward signaling appears to be an important mediator of VEGF induced angiogenesis since inhibition of EphB4 forward signaling is sufficient to inhibit VEGF induced angiogenesis. Synonyms: NVP BHG712; NVP BHG-712; NVP BHG 712; BHG-712; BHG712; BHG 712. CAS No. 940310-85-0. Molecular formula: C26H20F3N7O. Mole weight: 503.489. | |
| NVP-BKM120 Hydrochloride | NVP-BKM120 Hcl(BKM120) is a selective PI3K inhibitor of p110α/β/δ/γ with IC50 of 52 nM/166 nM/116 nM/262 nM, respectively. Synonyms: BKM-120 hydrochloride; BKM120 hydrochloride; BKM 120 hydrochloride. Grades: >98%. CAS No. 1312445-63-8. Molecular formula: C18H22ClF3N6O2. Mole weight: 446.85. | |
| NVP-BVU972 | NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. Synonyms: NVP BVU972; NVPBVU972; NVP-BVU972; BVU-972; BVU 972; BVU972. Grades: >98%. CAS No. 1185763-69-2. Molecular formula: C20H16N6. Mole weight: 340.38. | |
| NVP-CGM097 sulfate | NVP-CGM097 sulfate, a dihydroisoquinolinone derivative, is a potent and selective MDM2 inhibitor (IC50 = 1.7±0.1 nM for hMDM2) in the treatment of p53wt tumors. Synonyms: (1S)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one;sulfuric acid; NVP-CGM097 (sulfate). CAS No. 1313367-56-4. Molecular formula: C38H49ClN4O8S. Mole weight: 757.34. | |
| NVP CXCR2 20 | NVP CXCR2 20 is a potent and selective CXCR2 antagonist. Synonyms: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile; NVP-CXCR2 20; NVP CXCR2-20; NVP CXCR220. CAS No. 1029521-30-9. Molecular formula: C15H11F2N3OS. Mole weight: 319.33. | |
| NVP DPP 728 dihydrochloride | NVP DPP 728, a cyanopyrrolidine, is a potent, orally active dipeptidyl peptidase (DPP)-IV inhibitor with excellent oral bioavailability and potent antihyperglycemic activity (Ki = 11 nM, IC50=14 nM). NVP DPP 728 exhibits > 15 000-fold selectivity over DPP-II and a range of proline-cleaving proteases. Synonyms: NVP DPP 728 dihydrochloride; NVPDPP728 dihydrochloride; NVP-DPP-728 dihydrochloride; 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile dihydrochloride. Grades: ≥97% by HPLC. CAS No. 207556-62-5. Molecular formula: C15H18N6O.2HCl. Mole weight: 371.27. | |
| NVP-LCQ195 | NVP-LCQ195 is a small molecule heterocyclic inhibitor of CDK1, CDK2, CDK3 and CDK5. It induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-lmol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. It suppressed the expression of transcription factors including myc, IRF4 and XBP-1. Synonyms: NVP-LCQ-195; NVP-LCQ 195; NVP-LCQ195. LCQ-195; LCQ 195; LCQ195; AT9311; AT-9311; AT 9311. Grades: >98%. CAS No. 902156-99-4. Molecular formula: C17H19Cl2N5O4S. Mole weight: 460.33. | |
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