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| Product | Description | |
|---|---|---|
| NGB 2904 | NGB 2904 is a dopamine D3 receptor antagonist. It can inhibit quinpirole-stimulated mitogenesis with IC50 value of 6.8 nM. Synonyms: NGB 2904; NGB2904; NGB-2904; N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 189061-11-8. Molecular formula: C28H29Cl2N3O.HCl. Mole weight: 530.92. |  |
| NGD 94-1 | NGD 94-1 is a dopamine D4 receptor ligand and it is selective over D1, D2, D3 and D5 receptors. Synonyms: NGD 94-1; NGD94-1; NGD-94-1; NGD941; 2-[4-[(2-Phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]-pyrimidine. Grades: ≥99% by HPLC. CAS No. 178928-68-2. Molecular formula: C18H20N6. Mole weight: 320.39. | |
| NGD 98-2 hydrochloride | NGD 98-2 hydrochloride is a corticotropin-releasing factor receptor 1 antagonist. Synonyms: N-(1-Ethylpropyl)-3-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]-6-methyl-2-pyrazinamine hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C19H24F3N3O3.HCl. Mole weight: 435.87. | |
| NG,NG-dimethyl-L-arginine hydrochloride | NG,NG-dimethyl-L-arginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor. ADMA interferes with L-arginine in the production of nitric oxide (NO), a key chemical involved in normal endothelial function and, by extension, cardiovascular health. Synonyms: ADMA; ADMA 2HCl; NG,NG-Dimethylarginine dihydrochloride; NG,NG-Dimethyl-L-arginine dihydrochloride; (2S) -2-amino-5-[[amino (dimethylamino) methylidene]amino]pentanoic acid dihydrochloride. Grades: ≥98%. CAS No. 220805-22-1. Molecular formula: C8H18N4O2·2HCl. Mole weight: 275.2. | |
| Nialamide | Nialamide is used as an antidepressant for it is a monoamine oxidase inhibitor (MAOI) of the hydrazine class. It might be efficient under the combination action with 5-hydroxytryptophan in antidepressant. Uses: Nialamide is a a monoamine oxidase inhibitor (maoi) of the hydrazine class that is useful as an antidepressant agent. Synonyms: N-benzyl-3-[2-(pyridine-4-carbonyl)hydrazinyl]propanamide. Grades: ≥ 99 %. CAS No. 51-12-7. Molecular formula: C16H18N4O2. Mole weight: 298.34. | |
| Niclosamide monohydrate | Niclosamide Monohydrate is used for the treatment of most tapeworm infections by inhibiting DNA replication. It inhibits the TNF-induced NF-κB reporter activity in a dose- and time-dependent manner in U2OS cells. It also inhibits TNF-induced degradation of IκBα and relocation of p65 in a dose- and time-dependent manner in HL-60, Molm13, or AML primary cells. Synonyms: Niclocide monohydrate; BAY2353 monohydrate; BAY 2353 monohydrate; BAY-2353 monohydrate; Cestocid monohydrate; Sagimid monohydrate; Yomesan monohydrate. Grades: >98%. CAS No. 73360-56-2. Molecular formula: C13H10Cl2N2O5. Mole weight: 345.13. | |
| Nicotinamide-Adenine-Dinucleotide-5-Hydroxy-4-Oxonorvaline | A luteinizing hormone releasing hormone (LHRH). Molecular formula: C26H35N8O18P2. Mole weight: 809.55. | |
| Nicotinamide Adenine Dinucleotide Cyclohexanone | Nicotinamide Adenine Dinucleotide Cyclohexanone (NADH) is a pivotal molecular entity within the biomedical sector. Its involvement spans across diverse metabolic pathways is assuming the role of a fundamental cofactor for a myriad of enzymatic reactions. Synonyms: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-[3-carbamoyl-4-[(1S)-2-oxocyclohexyl]pyridin-1-ium-1-yl]-3,4-dihydroxyoxolan-2-yl]methyl phosphate. Molecular formula: C27H35N7O15P2. Mole weight: 759.55. | |
| NIDA 41020 | NIDA-41020 is a CB1 cannabinoid receptor antagonist with Ki value of 4.1 nM. Synonyms: NIDA-41020; NIDA 41020; NIDA41020; N-(Piperidin-1-yl)-5-(4-methoxyphenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide. Grades: ≥99% by HPLC. CAS No. 502486-89-7. Molecular formula: C23H24Cl2N4O2. Mole weight: 459.37. | |
| Nifenalol HCl | Nifenalol, also known as INPEA, is a novel antagonist of β-adrenoceptors. Uses: The hydrochloride of nifenalol, a beta-adrenoceptor antagonist. Synonyms: 2-(Isopropylamino)-1-(p-nitrophenyl)ethanol hydrochloride; Nifenalol; Nifenalol HCl; INPEA. Grades: ≥98%. CAS No. 5704-60-9. Molecular formula: C11H17ClN2O3. Mole weight: 260.71. | |
| Nifeviroc | Nifeviroc is a CCR5 antagonist that can be used to treat HIV type 1 infection. Synonyms: 4-Nitrobenzyl Allyl(1-(((3S,4R)-1-(Cyclopentanecarbonyl)-4-Hydroxy-4-Phenylpyrrolidin-3-Yl)Methyl)Piperidin-4-Yl)Carbamate. Grades: ≥98% by HPLC. CAS No. 934740-33-7. Molecular formula: C33H42N4O6. Mole weight: 590.7. | |
| Nifursol | Nifursol, a nitrofuran antibiotic, has been used extensively as a feed additive for the prevention of histomoniasis (black head disease) in turkeys. Uses: A medicinal, prophylactic additive in animal feeds, protecting poultry from histomoniasis. Synonyms: 2-hydroxy-3,5-dinitro-N-[(E)-(5-nitrofuran-2-yl)methylideneamino]benzamide NIFURSOL Histomon Salfuride 16915-70-1 Sulfuride Nifursolo [DCIT] Nifursolum [INN-Latin] UNII-TG99GOU55Z EINECS 240-963-6 NCGC00160555-01 DSSTox_CID_26226 DSSTox_RID_81453 DSSTox_G. CAS No. 16915-70-1. Molecular formula: C12H7N5O9. Mole weight: 365.21. | |
| Niguldipine hydrochloride | Cas No. 119934-51-9. | |
| Nilotinib hydrochloride | Nilotinib is an orally bioavailable Bcr-Abl tyrosine kinase inhibitor displaying antineoplastic activity. It is promisingly used for the treatment of chronic myelogenous leukemia (CML). Uses: Tyrosine kinase inhibitors. Synonyms: AMN-107 HCl; 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzamide hydrochloride. CAS No. 923288-95-3. Molecular formula: C28H22F3N7O·HCl. Mole weight: 565.98. | |
| Ningetinib | Ningetinib is a potent, orally bioavailable small molecule tyrosine kinase inhibitor (TKI) with IC50s of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. In vivo, ningetinib (20 mg/kg) inhibits tumor growth in MKN45, Caki-1, NCI-H441, Huh-7, U87MG, and MDA-MB-231 mouse xenograft models by 53-97%. Synonyms: N-[3-Fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl]oxy]phenyl]-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; N-[3-Fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. CAS No. 1394820-69-9. Molecular formula: C31H29FN4O5. Mole weight: 728.79. | |
| Ningetinib-Tosylate | Ningetinib Tosylate is a small molecule tyrosine kinase inhibitor (TKI) with IC50 of 6.7, 1.9 and <1.0 nM for c-Met, VEGFR2 and Axl, respectively. Synonyms: N-(3-Fluoro-4-((7-(2-Hydroxy-2-Methylpropoxy)Quinolin-4-Yl)Oxy)Phenyl)-1,5-Dimethyl-3-Oxo-2-Phenyl-2,3-Dihydro-1H-Pyrazole-4-Carboxamide P-Toluenesulfonate. CAS No. 1394820-77-9. Molecular formula: C38H37FN4O8S. Mole weight: 728.8. | |
| (±)-Nipecotic acid | (±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. Synonyms: (±)-3-Piperidine Carboxylic Acid; Nipecotic Acid (6CI,7CI,8CI); (±)-b-Homoproline; 3-Carboxypiperidine; DL-Nipecotic Acid; Hexahydronicotinic Acid. CAS No. 60252-41-7. Molecular formula: C6H11NO2. Mole weight: 129.16. | |
| NITD-304 | NITD-304, an indole derivative, has been found to be an antitubercular agent that could be effective through influencing multidrug-resistant mycobacterium tuberculosis (Mtb). Synonyms: NITD-304; NITD 304; NITD304; 4,6-dichloro-N-(4,4-dimethylcyclohexyl)-1H-indole-2-carboxamide. Grades: 98%. CAS No. 1473450-60-0. Molecular formula: C17H20Cl2N2O. Mole weight: 339.26. | |
| Nitecapone | Nitecapone is a catechol-O-methyltransferase (COMT) inhibitor exhibiting antioxidant and gastroprotective properties. It is a potential therapeutic agent for Parkinson's disease. Study has shown that nitecapone decreased neuropathic pain in the spinal nerve ligation (SNL) model. Uses: Antioxidants. Synonyms: OR-462; 3-(3,4-dihydroxy-5-nitrobenzylidene)pentane-2,4-dione. Grades: ≥98%. CAS No. 116313-94-1. Molecular formula: C12H11NO6. Mole weight: 265.2. | |
| Nitrocaramiphen hydrochloride | Nitrocaramiphen hydrochloride is a mAChR M1 selective muscarinic antagonist, which exhibits 71-fold selectivity for M1 over M2. Synonyms: 2-(Diethylamino)ethyl Ester 1-(4-Nitrophenyl)cyclopentanecarboxylic Acid Hydrochloride; 1-(p-Nitrophenyl)-2-(diethylamino)ethylester Cyclopentanecarboxylic Acid Hydrochloride. Grades: ≥98% by HPLC. CAS No. 98636-73-8. Molecular formula: C18H26N2O4.HCl. Mole weight: 370.88. | |
| Nitrofurazone | Nitrofural is a topical anti-infective agent with an IC50 of 22.83 ± 1.2 μM. (Rat LD50=590 mg/kg). Synonyms: Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]-; 2-[ (5-Nitro-2-furanyl) methylene]hydrazinecarboxamide; 2-Furaldehyde, 5-nitro-, semicarbazone; Semioxamazide, 1-(5-nitrofurfurylidene)-; (5-Nitro-2-furfurylidenamino)urea; 1-(5-Nitro-2-furfurylidene)semicarbazide; 2-Furancarboxaldehyde, 5-nitro-, semicarbazone; 5-Nitro-2-furaldehyde semicarbazone; 5-Nitro-2-furfural semicarbazone; 5-Nitro-2-furfuraldehyde semicarbazone; 5-Nitrofurazone; 5-Nitrofurfural semicarbazone; Aldomycin; Alfucin; Amifur; Babrocid; Chemofuran; Coxistat; Fura-Septin; Furacilin; Furacilinum; Furacin; Furacine; Furacinetten; Furacycline; Furaplast; Furaziline; Furesol; Mammex; Mastofuran; Monafuracin; Nefco; NFS; Nfz mix; Nifucin; Nifuzon; Nitrofural; Nitrofuraldehyde semicarbazone; Nitrofuran (bactericide); Nitrozone; NSC 1602; NSC 2100; NSC 44009; Otofural; Topifuran; Vabrocid; Veterinary nitrofurazone. Grades: >98%. CAS No. 59-87-0. Molecular formula: C6H6N4O4. Mole weight: 198.14. | |
| Nizatidine | Nizatidine is a histamine H2 receptor antagonist with IC50 of 0.9 nM, also inhibits AChE with IC50 of 6.7 μM. Synonyms: Nizatidine, LY-139037, Tazac, Axid, LY 139037, LY139037; DL-Octopamine hydrochloride. Grades: >98%. CAS No. 76963-41-2. Molecular formula: C12H21N5O2S2. Mole weight: 331.46. | |
| NKL-22 | NKL-22 is a HDAC inhibitor with IC 50 value of 78 uM. It is a cell-permeable pimeloylanilide compound which acts as a FXN-(frataxin gene) specific HDAC inhibitor. It increase frataxin protein concentrations. It increase FXN mRNA in FRDA lymphocytes. Uses: Nkl-22 it increase fxn mrna in frda lymphocytes. Synonyms: HDAC inhibitor IV; NKL 22; NKL-22; NKL22; MDK-4154; MDK4154; MDK4154; N-(2-Aminophenyl)-N'-phenylheptanediamide;HDAC inhibitor IV;N1-(2-Aminophenyl)-N7-phenylheptanediamide;Histone Deacetylase Inhibitor IV. Grades: 98%. CAS No. 537034-15-4. Molecular formula: C19H23N3O2. Mole weight: 325.40. | |
| NL-103 | NL-103, a nicotinamide derivative, has been found to be an inhibitor of both histone deacetylases and hedgehog pathway. It was found to exhibit activity in decreasing the expression of Gli2 so that could probably be significant in the biological studies of Hh pathway. Synonyms: NL-103; NL 103; NL103; N-(4-chloro-3-(3-chlorobenzamido)phenyl)-6-((7-(hydroxyamino)-7-oxoheptyl)amino)nicotinamide. Grades: 98%. CAS No. 1788896-33-2. Molecular formula: C71H108N18O14. Mole weight: 1437.76. | |
| NLS-StAx-h | NLS-StAx-h is a cell-permeable Wnt inhibitor that potently suppresses β-catenin-transcription factor interactions. CAS No. 2872559-21-0. Molecular formula: C161H275N55O29. Mole weight: 3445.26. | |
| N-Methyl-N-propyl-2-aminotetraline hydrochloride | N-Methyl-N-propyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist. Synonyms: Aminotetraline hydrochloride, N-Methyl-N-propyl-2-; N-methyl-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride. Grades: 98%. CAS No. 134467-74-6. Molecular formula: C14H21N.HCl. Mole weight: 239.78. | |
| N-Methylquipazine dimaleate | N-Methylquipazine dimaleate, a tertiary amine analog of quipazine, is a 5-HT3 agonist, which has almost the same affinity for 5-HT3 sites as quipazine but unlike the latter, does not bind to 5-HT1B sites. Synonyms: 2-(1-N-Methylpiperazinyl)quinoline dimaleate. CAS No. 171205-17-7. Molecular formula: C14H17N3.(C4H4O4)2. Mole weight: 459.45. | |
| N-MPPP Hydrochloride | N-MPPP Hydrochloride is a high affinity and selective agonist of the κ opioid receptor (KOR-1) with no measured binding at μ or δ sites. Synonyms: N-Methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]phenylacetamide hydrochloride. CAS No. 207452-97-9. Molecular formula: C21H26N2O.HCl. Mole weight: 358.91. | |
| NMS-1286937 | NMS1286937, also know as NMS-P937, is an orally bioavailable, small-molecule Polo-like kinase 1 (PLK1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor NMS-1286937 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressing tumor cells. PLK1 is a serine/threonine protein kinase crucial in the regulation of mitosis. Uses: Protein kinase inhibitors. Synonyms: PCM-075; PCM 075; PCM075; NMS1286937; NMS 1286937; NMS-1286937; NMS-P937; NMS-P-937; NMS-P 937; Onvansertib. Grades: >98%. CAS No. 1034616-18-6. Molecular formula: C24H27F3N8O3. Mole weight: 532.53. | |
| NMS-E973 | NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases. NMS-E973 shows a widespread antiproliferative activity with an average IC50 of 1.6 μM, and induces the degradation of client protein. Synonyms: NMS-E973; NMSE973; NMS E973. Grades:>98%. CAS No. 1253584-84-7. Molecular formula: C22H22N4O7. Mole weight: 454.43. | |
| NMS-P118 | NMS-P118 is a highly selective Poly(ADP-ribose) Polymerase 1 (PARP-1) inhibitor with excellent ADME, pharmacokinetic profiles and high efficacy in vivo originated by Nerviano Medical Sciences. It was found to be less myelotoxic in vitro than olaparib which is a dual PARP-1/-2 inhibitor. It was in preclinical trials for Breast cancer, but no development had been published yet. Uses: Breast cancer. Synonyms: NMS-P118; NMS-P 118; NMS P118. 2-[1-(4,4-difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide. Grades: 98%. CAS No. 1262417-51-5. Molecular formula: C20H24F3N3O2. Mole weight: 395.42. | |
| NNC 05-2090 hydrochloride | NNC052090 is a GABA uptake inhibitor that displays selectivity for BGT-1 (mGAT-2) transporters. Synonyms: NNC 05 2090 hydrochloride; NNC05-2090 hydrochloride; NNC052090 hydrochloride; 1-[3-(9H-Carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-4-piperidinol hydrochloride; 4-Piperidinol, 1-[3-(9H-carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-, hydrochloride (1:1); 4-Piperidinol, 1-[3-(9H-carbazol-9-yl)propyl]-4-(2-methoxyphenyl)-, monohydrochloride; NNC 05-2090 monohydrochloride. Grades: ≥98% by HPLC. CAS No. 184845-18-9. Molecular formula: C27H30N2O2.HCl. Mole weight: 451.01. | |
| NNC0640 | NNC0640 is a potent human G protein-coupled glucagon receptor (GCGR) negative allosteric modulator (NAM) with an IC50 of 69.2 nM. It is also a negative allosteric modulator of the glucagon-like peptide-1 receptor (GLP-1R). Synonyms: 4-[1-(4-Cyclohexylphenyl)-3-(3-Methanesulfonylphenyl)Ureidomethyl]-N-(2H-Tetrazol-5-Yl)Benzamide; NNC-0640. Grades: ≥98% by HPLC. CAS No. 307986-98-7. Molecular formula: C29H31N7O4S. Mole weight: 573.7. | |
| NNC 26-9100 | NNC269100 is a somatostatin sst4 receptor agonist. It can inhibit forskolin-induced cAMP accumulation whit EC50 value of 26 nM. Synonyms: NNC269100; NNC 269100; NNC-269100. 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea. Grades: ≥99% by HPLC. CAS No. 199522-35-5. Molecular formula: C22H25N6Cl2SBr. Mole weight: 556.35. | |
| NNC 55-0396 dihydrochloride | NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker (IC50=6.8 nM). Uses: Highly selective t-type calcium channel blocker. Synonyms: [(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] cyclopropanecarboxylate; dihydrochloride. Grades: ≥98%. CAS No. 357400-13-6. Molecular formula: C30H38FN3O2.2HCl. Mole weight: 564.56. | |
| NNC 711 | NNC 711 is a GABA uptake inhibitor by GAT-1 with IC50 values of 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1. NNC 711 is an anticonvulsantagent. Uses: Gaba antagonists. Synonyms: NNC 711; NNC711; NNC-711; 1, 2, 5, 6-Tetrahydro-1-[2-[[ (diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 145645-62-1. Molecular formula: C21H22N2O3.HCl. Mole weight: 386.88. | |
| N,N-dibutyldopamine hydrobromide | A dopamine receptor agonist. Synonyms: 4-[2-(dibutylamino)ethyl]benzene-1,2-diol hydrobromide. Grades: 99%. CAS No. 65273-67-8. Molecular formula: C16H27NO2.HBr. Mole weight: 346.3. | |
| N,N-Dipropyldopamine hydrobromide | A dopamine receptor agonist. Synonyms: Dipropyldopamine hydrobromide; DPDA; N,N-Dipropyldopamine; EU-0100465; EU 0100465; EU0100465; 4-[2-(dipropylamino)ethyl]benzene-1,2-diol hydrobromide. Grades: 98%. CAS No. 65273-66-7. Molecular formula: C14H23NO2.HBr. Mole weight: 318.25. | |
| NNGH | NNGH is a cell-permeable inhibitor of matrix metalloproteinases (MMPs). It has been used to study the role of MMP-3 (stromelysin 1) in biological systems. Synonyms: N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid; ??Matrix Metalloproteinase-3 Inhibitor II; MMP-3 Inhibitor II; N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide. Grades: ≥99%. CAS No. 161314-17-6. Molecular formula: C13H20N2O5S. Mole weight: 316.4. | |
| nNOS Inhibitor I | nNOS inhibitor I is a cell-permeable nNOS inhibitor with Ki value of 120 nM. It displays >2,500-fold and 320-fold selectivity for nNOS over eNOS and iNOS, respectively. Synonyms: NOS I; ncNOS; N-[(4S)-4-Amino-5-[(2-aminoethyl]amino]P; N-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-N'-nitroguanidine tris(trifluoroacetate) salt. Grades: ≥95%. CAS No. 357965-99-2. Molecular formula: C8H21N7O2·3CF3COOH. Mole weight: 589.4. | |
| Nociceptin (1-7) | Nociceptin (1-7), the N-terminal fragment of Nociceptin, antagonizes nociceptin-induced hyperalgesia, with no effect on nociceptin-induced analgesia. Synonyms: L-Phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanine; 1-7-Orphanin FQ (pig); (2S) -2- [ [2- [ [ (2S, 3R) -2- [ [ (2S) -2- [ [2- [ [2- [ [ (2S) -2-amino-3-phenylpropanoyl] amino] acetyl] amino] acetyl] amino] -3-phenylpropanoyl] amino] -3-hydroxybutanoyl] amino] acetyl] amino] propanoic acid. CAS No. 178249-42-8. Molecular formula: C31H41N7O9. Mole weight: 655.7. | |
| NocII | NocII, a heptadecapeptide whose sequence lies immediately downstream of nociceptin, stimulates locomotion in mice, possibly through a novel specific receptor. Synonyms: NocII; 188119-47-3; Orphanin FQ 2 (mouse); AKOS024456395; PD079090. CAS No. 188119-47-3. Molecular formula: C92H141N23O28S2. Mole weight: 2081.4. | |
| Nocistatin (human) | Nocistatin (human) is a human putative counterpart of nocistatin (bovine). Nocistatin is widely present in the spinal cord and brain, and is a novel bioactive peptide produced from the same precursor as Noc/OFQ. Nocistatin plays important roles in the regulation of pain transmission and learning and memory processes in the central nervous system. Synonyms: Glu-Gln-Lys-Gln-Leu-Gln. CAS No. 212609-11-5. Molecular formula: C149H238N42O53S3. Mole weight: 3561.93. | |
| Nocodazole | Nocodazole, also called Oncodazole, reversibly inhibits microtubule polymerization so it has anti-neoplastic effect. It is inhibitor of Abl (IC50= 0.21 μM), Abl(E255K) (IC50= 0.53 μM)and Abl(T315I) (IC50= 0.53 μM). in vitro: a high-affinity ligand for Abl phosphorylated (Kd= 0.091 μM), c-Kit (Kd= 1.6 μM), BRAF (Kd= 1.8 μM), and MEK (Kd= 1.6 μM) in vivo: combined with Ketoconazole strongly enhances apoptosis of COLO 205 tumor xenografts. Synonyms: methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate; nocodazole; Oncodazole; 31430-18-9; R 17934; Nocodazolum; Nocidazole; Nocodazol; NSC 238159; Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate; Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate; NSC-238159; R-17934; R 17,934; C14H11N3O3S; Methyl 5-(2-thenoyl)-2-benzimidazolecarbamate; Nocodazole [USAN:INN]. CAS No. 31430-18-9. Molecular formula: C14H11N3O3S. Mole weight: 301.32. | |
| N-Octadecyl-N'-propyl-sulfamide | N-Octadecyl-N'-propyl-sulfamide is an analog of oleoyl ethanolamide (OEA) that acts as a PPARα activator, modulating lipid and glucose metabolism. At a dose of 1 mg/kg for 8-11 days, N-octadecyl-N'-propyl-sulfamide decreased food-intake, body weight gain, and plasma triglyceride concentration in free-feeding Wistar and obese Zucker (fa/fa) rats. Synonyms: N-(propylsulfamoyl)octadecan-1-amine. Grades: ≥95%. CAS No. 925891-74-3. Molecular formula: C21H46N2O2S. Mole weight: 390.7. | |
| N-Oleoyl Valine | N-Oleoyl valine is an antagonist at the transient receptor potential vanilloid type 3 (TRPV3) receptor. Synonyms: N-[(9Z)-1-oxo-9-octadecen-1-yl]-L-valine; (2S)-3-Methyl-2-[[(Z)-octadec-9-enoyl]amino]butanoic acid. Grades: ≥98%. CAS No. 60374-41-6. Molecular formula: C23H43NO3. Mole weight: 381.6. | |
| Nolomirole hydrochloride | Nolomirole is a Alpha 2 adrenergic receptor and Dopamine D2 receptor agonist. Nolomirole can attenuate the heart failure signs in the monocrotaline-induced congestive heart failure. Phase-III clinical trials for Congestive heart failure in Europe was discontinued. Uses: Heart failure. Synonyms: CHF1035; CHF-1035; CHF 1035; Nolomirole Hydrochloride; Nolomirole HCl; 6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diyl bis(2-methylpropanoate) hydrochloride. Grades: 98%. CAS No. 138531-51-8. Molecular formula: C19H28ClNO4. Mole weight: 369.89. | |
| Nω-Propyl-L-arginine hydrochloride | Nω-Propyl-L-arginine hydrochloride is a neuronal selective nitric oxide synthase inhibitor and a potent and selective inhibitor of NOS1 (nNOS) (Ki = 57 nM) with 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo. Synonyms: N5-[Imino(propylamino)methyl]-L-ornithine hydrochloride. Grades: ≥98% by HPLC. CAS No. 137361-05-8. Molecular formula: C9H20N4O2.HCl. Mole weight: 252.74. | |
| Nomifensine | Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it is an antidepressant drug but due to increased incidence of hemolytic anemia, as well as kidney and liver toxicity it was withdrawn from the market. Uses: A novel antidepressant distinguished from existing tricyclic and tetracyclic antidepressants by its bicyclic structure. Synonyms: Nomifensine; CCRIS 9179; HSDB 7702; Linamiphen; 2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amineHoe 984Hoe-984Hoe984LinamiphenMaleate, NomifensineMeritalNomifensinNomifens ineNomifensine MaleateNomifensine Maleate (1:1). Grades: 95%. CAS No. 24526-64-5. Molecular formula: C16H18N2.C4H4O4. Mole weight: 354.40. | |
| Nomifensine maleate | Nomifensine maleate is maleate salt form of Nomifensine. Nomifensine, also called as Hoe 984 or Linamiphen, as a norepinephrine-dopamine reuptake inhibitor it is an antidepressant drug but due to increased incidence of hemolytic anemia, as well as kidney. Synonyms: (Z)-but-2-enedioic acid;2-methyl-4-phenyl-3,4-dihydro-1H-isoquinolin-8-amine Hoe 984 Hoe-984 Hoe984 Linamiphen Maleate, Nomifensine Merital Nomifensin Nomifensine Nomifensine Maleate Nomifensine Maleate (1:1). CAS No. 32795-47-4. Molecular formula: C20H22N2O4. Mole weight: 354.40. | |
| nor-Binaltorphimine dihydrochloride | nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist. Synonyms: Nor-BNI dihydrochloride; 17,17'-(Dicyclopropylmethyl)-6,6',7,7'-6,6'-imino- 7,7'-binorphinan-3,4',14,14'-tetrol dihydrochloride. Grades: ≥98% by HPLC. CAS No. 113158-34-2. Molecular formula: C40H43N3O6.2HCl. Mole weight: 734.72. | |
| Norfloxacin Hydrochloride | Norfloxacin hydrochloride is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division. It is a synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Synonyms: Noroxin hydrochloride; Chibroxin hydrochloride. Grades: >98%. CAS No. 68077-27-0. Molecular formula: C16H19ClFN3O3. Mole weight: 355.79. | |
| (±)-Nornicotine | Cas No. 5746-86-1. | |
| Norvancomycin hydrochloride | Norvancomycin hydrochloride is an antibacterial agent. Synonyms: Desmethyl-vancomycin hydrochloride. CAS No. 213997-73-0. Molecular formula: C65H74Cl3N9O24. Mole weight: 1471.69. | |
| Noscapine hydrochloride | Noscapine hydrochloride, the hydrochloride salt form of Noscapine which binds to tubulin and arrests mammalian cells in mitosis at a concentration of 20 μM. Noscapine induces apoptosis (in HeLa cells: IC50=25 μM; in thymocytes: IC50=10 μM) and inhibit CYP2C19 (IC50 = 400.3 nM (human)), HepG2 (IC50 >1000 nM (human)) and A549 (EC5050 = 25 μM (human)). Uses: Antitussive agents. Synonyms: 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride (1:1), (3S)-; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, hydrochloride, [S-(R*,S*)]-; 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, monohydrochloride, (3S)-; Narcotine, hydrochloride; l-Narcotine hydrochloride; Opianine hydrochloride. Grades: ≥95%. CAS No. 912-60-7. Molecular formula: C22H23NO7.HCl. Mole weight: 449.88. | |
| Novokinin | Novokinin, designed based on the structure of ovokinin, is an angiotensin AT2 receptor agonist (Ki = 7.35 μM) that displays 93-fold selectivity over AT1. Novokinin exhibits vasorelaxing and hypotensive activity via activation of the IP (prostacyclin) receptor, and suppresses food intake via activation of PGE2-EP4 interaction. Synonyms: Novokinin; L-arginyl-L-prolyl-L-leucyl-L-lysyl-L-prolyl-L-tryptophan. CAS No. 358738-77-9. Molecular formula: C39H61N11O7. Mole weight: 795.98. | |
| NP-118809 | NP-118809 is a N-type calcium channel blocker exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain. Uses: An analog of cinnarizine, a calcium channel blocker as anti-inflammatory agent. Synonyms: 39-1B4; NP 118809; NP-118809; NP118809; Z160; Z160; Z160. 1-(4-benzhydrylpiperazin-1-yl)-3,3-diphenylpropan-1-one; 1-(Diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine. Grades: ≥98%. CAS No. 41332-24-5. Molecular formula: C32H32N2O. Mole weight: 460.61. | |
| N-(p-amylcinnamoyl)anthranilic acid | N-(p-amylcinnamoyl)anthranilic acid is a TPR channel blocker and phospholipase A2 (PLA2) inhibitor. It blocks the receptor-induced release of arachidonic acid and subsequent signaling cascades in the pancreas and the cardiovascular system. Synonyms: Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-; 2-[[1-Oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]benzoic acid; Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]-; N-(4-Pentylcinnamoyl)anthranilic acid; N-(para-Amylcinnamoyl)anthranilic acid. Grades: ≥95%. CAS No. 110683-10-8. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| NPC-15437 hydrochloride | NPC-15437 is a selective protein kinase C (PKC) inhibitor with IC50 value of 19 μM. It dose-dependently induced deficit of memory retention in mice as PKC signaling is involved in memory processes. Synonyms: NPC 15437 dihydrochloride; (S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride. Grades: ≥95%. CAS No. 141774-20-1. Molecular formula: C25H50N4O2·2HCl. Mole weight: 511.6. | |
| NPEC-caged-(1S,3R)-ACPD | A caged version of (1S,3R)-ACPD. (1S,3R)-ACPD is a group I/II mGlu agonist. Synonyms: (1S, 3R) -1- (2-Nitrophenyl) ethylcarboxyaminocyclopentane-1, 3-dicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1315379-60-2. Molecular formula: C16H18N2O8. Mole weight: 366.32. | |
| NPEC-caged-D-AP5 | A caged version of D-AP5. D-AP5 is an antagonist of the NMDA receptor. Synonyms: D-[[1-(2-Nitrophenyl)ethyl]carbamoyl]-2-amino]-5-phosphonopentanoic acid. Grades: ≥99% by HPLC. CAS No. 1416943-27-5. Molecular formula: C14H19N2O9P. Mole weight: 390.28. | |
| NPEC-caged-dopamine | NPEC-caged-dopamine is a caged version of dopamine. It can release dopamine leading to dopamine D1 receptor activation upon UV light illumination. Synonyms: (N)-1-(2-Nitrophenyl)ethylcarboxy-3,4-dihydroxyphenethylamine. Grades: ≥99% by HPLC. CAS No. 1257326-23-0. Molecular formula: C17H18N2O6. Mole weight: 346.33. | |
| NPEC-caged-LY 379268 | A caged version of LY 379268. LY 379268 is a selective group II mGlu receptor agonist. Synonyms: (N)-1-(2-Nitrophenyl)ethylcarboxy-(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid. Grades: ≥98% by HPLC. Molecular formula: C16H16N2O9. Mole weight: 380.31. | |
| NPEC-caged-(S)-3,4-DCPG | A caged version of (S)-3,4-DCPG. (S)-3,4-DCPG is a selective mGlu8a agonist. Synonyms: (N)-1-(2-Nitrophenyl)ethylcarboxy-(S)-3,4-Dicarboxyphenylglycine. Grades: ≥98% by HPLC. CAS No. 1257323-85-5. Molecular formula: C19H16N2O10. Mole weight: 432.34. | |
| NPEC-caged-(S)-AMPA | A caged version of (S)-AMPA. (S)-AMPA is an AMPA receptor agonist. Synonyms: (N)-1-(2-Nitrophenyl)ethylcarboxy-(S)-α-1-(2-nitrophenyl)ethylcarboxyamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. Grades: ≥98% by HPLC. CAS No. 1257323-84-4. Molecular formula: C16H17N3O8. Mole weight: 379.32. | |
| NPEC-caged serotonin | NPEC-caged serotonin is a caged version of serotonin. Synonyms: 3-((N)-1-(2-Nitrophenyl)ethylcarboxy)-(2-Aminoethyl)-1H-indol-5-ol. Grades: ≥99% by HPLC. CAS No. 1257326-22-9. Molecular formula: C19H19N3O5. Mole weight: 369.37. | |
| [Nphe1]Nociceptin(1-13)NH2 | [Nphe1]Nociceptin(1-13)NH2 acts as the first truly selective and competitive nociceptin receptor antagonist and is devoid of any residual agonist activity. It binds selectively to recombinant nociceptin receptors (pKi = 8.4), and competitively antagonizes the actions of nociceptin in vitro and in vivo. Synonyms: (S, Z)-6-amino-N-((S, Z)-1-(((S, Z)-1-(((S, Z)-1-(((S)-6-amino-1-hydroxy-1-iminohexan-2-yl)imino)-5-guanidino-1-hydroxypentan-2-yl)imino)-1-hydroxypropan-2-yl)imino)-1, 3-dihydroxypropan-2-yl)-2-((Z)-((4Z, 7Z, 10Z, 12S, 13Z, 15S, 16Z, 19Z, 21S, 22Z, 24S)-12-benzyl-24-(3. CAS No. 267234-08-2. Molecular formula: C61H100N22O15. Mole weight: 1381.6. | |
| NPPB | NPPB is a chloride channel blocker with IC50 value of 80 nM. NPPB has protonophoric activity. It has been used to uncouple mitochondrial ATP synthesis in phagocytes. Uses: Angiogenesis inhibitors. Synonyms: 5-Nitro-2-(3-phenylpropylamino)benzoic acid. Grades: ≥99% by HPLC. CAS No. 107254-86-4. Molecular formula: C16H16N2O4. Mole weight: 300.31. | |
| (-)-NPPCC | (-)-NPPCC is a potent and selective 5-HT1A receptor agonist. Synonyms: NPPCC, (-)-; N- [ [ (2S) -1-Phenethyl-2-pyrrolidinyl] methyl] cyclohexanecarboxamide. Grades: 98%. CAS No. 265644-16-4. Molecular formula: C20H30N2O. Mole weight: 314.47. | |
| NPS-1034 | NPS-1034 is a novel MET inhibitor, which inhibits the activated MET receptor and its constitutively active mutants. NPS-1034, inhibits various constitutively active mutant forms of MET as well as HGF-activated wild-type MET. NPS-1034 inhibited the proliferation of cells expressing activated MET and promoted the regression of tumors formed from such cells in a mouse xenograft model through anti-angiogenic and pro-apoptotic actions. NPS-1034 also inhibited HGF-stimulated activation of MET signaling in the presence or absence of serum. Notably, NPS-1034 inhibited three MET variants that are resistant to the MET inhibitors SU11274, NVP-BVU972, and PHA665752. Synonyms: NPS-1034; NPS1034; NPS 1034. Grades: 98%. CAS No. 1221713-92-3. Molecular formula: C31H23F2N5O3. Mole weight: 551.554. | |
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