BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| NVP-QAV-572 | NVP-QAV-572 is a potent PI3K kianse inhibitor. Grades: >98%. CAS No. 957209-68-6. Molecular formula: C17H19F2N7O3S2. Mole weight: 471.5. |  |
| NVS-CECR2-1 | NVS-CECR2-1 is a potent and selective CECR2 (cat eye syndrome chromosome region, candidate 2) inhibitor (IC50 = 47 nM). NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. CECR2 (cat eye syndrome chromosome region, candidate 2) is a component of chromatin complexes that regulate gene expression controlling development. Synonyms: NVS-CECR2-1; NVS CECR2 1; NVSCECR21; NVS-1; NVS 1; NVS1; N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine. Grades: ≥98% by HPLC. CAS No. 1992047-61-6. Molecular formula: C27H37N5O2S. Mole weight: 495.68. | |
| NW457 | NW-457 is a potent Hsp90 inhibitor with no detectable hepatocytotoxicity in vitro. It synergizes with ionizing irradiation to induce chromatin condensation, nuclear fragmentation, apoptosis, and post-apoptotic, secondary necrosis. Enhanced apoptosis induction by NW457 in combination with irradiation is accompanied by increased caspase activation and caspase substrate cleavage. Synonyms: NW457; NW 457; NW-457; 1H-2-Benzoxacyclotetradec?in-1,?11(12H)?-dione, 3,?4,?7,?8-tetrahydro-7,?14,?16-trihydroxy-3-methyl-, 11-[O-[2-oxo-2-(1-piperidinyl)?ethyl]?oxime]?, (3S,?5E,?9E,?11E)?-. Grades: >98%. CAS No. 1373761-12-6. Molecular formula: C25H32N2O7. Mole weight: 472.53. | |
| NXD30001 | NXD30001 inhibits Hsp90, potentially resulting in decreased tumor growth. Synonyms: NXD30001; NXD 30001; NXD-30001. Grades: >98%. CAS No. 1223580-83-3. | |
| Nylidrin hydrochloride | Nylidrin hydrochloride is a beta-adrenergic agonist. It was an effective inhibitor of IgE-mediated release of histamine from passively sensitized rat peritoneal mast cells and human basophils, and of IgG1-mediated release of histamine from passively sensitized guinea pig lung slices. It causes peripheral vasodilation, a positive inotropic effect, and increases gastric volume of gastric juice. It is used in the treatment of peripheral vascular disorders and premature labor. It also can be used as antiallergic agent. It is one of the FDA approved drug as Inhibitors of the Human Sodium Taurocholate Cotransporting Polypeptide (NTCP). Uses: Nylidrin hydrochloride is used in the treatment of peripheral vascular disorders and premature labor. it also can be used as antiallergic agent. Synonyms: 1-p-Hydroxyphenyl-2-(1'-methyl-3'-phenylpropylamino)-1-propanolhydrochloride;Arlidin hydrochloride;Buphenine hydrochloride;Dilatol hydrochloride;p-Hydroxy-alpha-(1-((1-methyl-3-phenylpropyl)amino)ethyl)-benzylalcohohyd;Suprifenpsb hydrochloride; 4-[1-hydroxy-2-(4-phenylbutan-2-ylamino)propyl]phenol; hydrochloride; Dilatyl. Grades: 95%. CAS No. 849-55-8. Molecular formula: C19H26NO2Cl. Mole weight: 335.87. | |
| O-1918 | O-1918 is a cannabidiol analog and a selective, silent antagonist of a putative endothelial anandamide receptor distinct from CB1 or CB2 receptors. It is also an inhibitor of GPR18. It does not bind to CB1 or CB2 receptors at concentrations up to 30 μM. It inhibits endothelium-dependent vasodilation and cell migration induced by abnormal-cannabidiol in vitro and in whole animals. It also blocks the abnormal cannabidiol-induced activation of the phosphatidylinositol 3-kinase/Akt pathway in human umbilical vein endothelial cells. Synonyms: O-1918; O 1918; O1918; 1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene. Grades: ≥97% by HPLC. CAS No. 536697-79-7. Molecular formula: C19H26O2. Mole weight: 286.41. | |
| O-2050 | O-2050 is a high affinity neutral cannabinoid 1-receptor silent antagonist. It is used for the mechanistic effects and analysis of cannabinoids in the body. It is known to decrease food and water consumption in rats, and stimulate locomotor activity in rodents. It is also used as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation, with EC50 value of 40.4 nM. It also shows antagonist effects of CP55,940 in vitro. Synonyms: O-2050; O 2050; O2050; rel-N-[6-[(6aR,10aR)-6a,7,10,10a-Tetrahydro-1-hydroxy-6,6,9-trimethyl-6H-dibenzo[b,d]pyran-3-yl]-4-hexyn-1-yl]methanesulfonamide; (6aR,10aR)-1-Hydroxy-3-(1-Methanesulfonylamino-4-hexyn-6-yl)-6a,7,10,10a-tetrahydro-6,6,9-trimethyl-6H-dibenzo[b,d]pyran. Grades: ≥97% by HPLC. CAS No. 851320-29-1. Molecular formula: C23H31NO4S. Mole weight: 417.56. | |
| O-304 | O-304 is a first-in-class orally available pan-activator of AMP-activated protein kinase (AMPK). In preclinical models of hyperglycaemia/diabetes, O-304 increases glucose uptake in skeletal muscle, reduces insulin resistance and promotes β-cell rest. O-304 is identified as a drug candidate for the treatment of type 2 diabetes mellitus. Synonyms: 4-Chloro-N-[2-[(4-chlorophenyl)methyl]-3-oxo-1,2,4-thiadiazol-5-yl]benzamide. Grades: ≥98%. CAS No. 1261289-04-6. Molecular formula: C16H11Cl2N3O2S. Mole weight: 380.25. | |
| o-3M3FBS | O-3M3FBS is an activator of phospholipase C (PLC). It stimulates cytoplasmic calcium increase, inositol phosphate formation and superoxide generation in humans. It is used to study PLC signaling in cells and animals in conjunction with the PLC inhibitor U-73122. It is an inactive analog of m-3M3FBS and can be used as a negative control. Synonyms: o-3M3FBS; o 3M3FBS; o3M3FBS; 2,4,6-Trimethyl-N-[2-(trifluoromethyl)phenyl]-benzenesulfonamide. Grades: ≥99% by HPLC. CAS No. 313981-55-4. Molecular formula: C16H16F3NO2S. Mole weight: 343.36. | |
| O-Acetyl-L-carnitine hydrochloride | O-Acetyl-L-carnitine hydrochloride is an acetic acid ester of L-carnitine that transports fatty acids into the mitochondria. It was demonstrated that exhibits antidepressant and neuroprotective activity, and it can upregulate metabotropic glutamate receptor 2 (mGlu2). Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Acetyl-L-carnitine hydrochloride; O-Acetyl-L-carnitine HCl; [(2R)-2-acetyloxy-3-carboxypropyl]-trimethylazanium chloride. CAS No. 5080-50-2. Molecular formula: C9H17NO4.HCl. Mole weight: 239.696. | |
| O-Arachidonoyl ethanolamine hydrochloride | O-Arachidonoyl ethanolamine hydrochloride (O-AEA) is an AEA derivative that acts as a partial antagonist of CB1 receptor and a full agonist of CB2 receptor. O-AEA produced hypothermia in the mouse and acted as an antagonist in the presence of anandamide both in vivo and in vitro. Synonyms: O-AEA hydrochloride; Arachidonic acid-(2-aminoethyl)-ester hydrochloride; Virodhamine hydrochloride; 2-aminoethyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate hydrochloride. Grades: ≥98%. CAS No. 443129-35-9. Molecular formula: C22H37NO2·HCl. Mole weight: 384. | |
| OB 24 hydrochloride | OB 24 hydrochloride is a selective heme oxygenase 1 (HO-1) inhibitor with IC50 value of 1.9μM. It can inhibit cell proliferation in vitro, PCA tumor growth and lymph node/lung metastases in vivo. Synonyms: OB-24 hydrochloride; OB 24 hydrochloride; OB24 hydrochloride; OB-24 HCl; OB 24 HCl; OB24 HCl; 1-[[2-[2-(4-Bromophenyl)ethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 939825-12-4. Molecular formula: C15H17BrN2O2.HCl. Mole weight: 373.67. | |
| OBAA | OBAA is a phospholipase A2 inhibitor with IC50 value of 70 nM. It can reduce bronchospasm in guinea pigs in vivo. Synonyms: 2-Butenoic acid, 4-(4-octadecylphenyl)-4-oxo-, (2E)-; (2E)-4-(4-Octadecylphenyl)-4-oxo-2-butenoic acid. Grades: ≥95%. CAS No. 221632-26-4. Molecular formula: C28H44O3. Mole weight: 428.65. | |
| O-(Carboxymethyl)hydroxylamine hemihydrochloride | Aminooxyacetic acid (AOA) hemihydrochloride is a malate-aspartate shuttle (MAS) inhibitor which also inhibits the GABA degradating enzyme GABA-T. Aminooxyacetic acid hemihydrochloride treatment produces a significant increase in the percentage of the cells arrested in the stage of G0/G1, as well as a significant decrease in the percentage of the cells at S phase and G2/M phase. Synonyms: AOA hemihydrochloride. Grades: > 98.0 % (T). CAS No. 2921-14-4. Molecular formula: C4H11ClN2O6. Mole weight: 109.30. | |
| Ocedurenone | Ocedurenone is a non-steroidal mineralocorticoid receptor antagonist. Synonyms: Ocedurenona; Ocedurenonum. Grades: >98%. CAS No. 1359969-24-6. Molecular formula: C28H30ClN5O2. Mole weight: 504.0. | |
| (+)-Ochromycinone | STA-21 is a natural antibiotic that selectively inhibits STAT3. It suppresses STAT3 dimerization and DNA binding. It blocks the growth and survival of cancer cells expressing active STAT3. Synonyms: Ochromycinone; (+)-Ochromycinone; (3S)-8-hydroxy-3-methyl-3,4-dihydro-2H-benzo[a]anthracene-1,7,12-trione. Grades: ≥98%. CAS No. 28882-53-3. Molecular formula: C19H14O4. Mole weight: 306.3. | |
| Ocinaplon | Ocinaplon is a GABAA receptor modulator and it can be used for the treatment of generalized anxiety disorder. Synonyms: Ocinaplon; CL 273,547; CL 273547; CL273547; DOV 273,547; 2-Pyridinyl[7-(4-pyridinyl)pyrazolo[1,5-a]pyrimidin-3-yl]methanone. Grades: ≥98% by HPLC. CAS No. 96604-21-6. Molecular formula: C17H11N5O. Mole weight: 301.3. | |
| Octreotide Acetate (Random Configuration) | Octreotide is an octapeptide that mimics somatostatin binding to somatostatin receptors (SSTRs) with higher affinity. It effectively inhibits growth hormone, glucagon, and insulin both in vitro and in vivo. Synonyms: SMS 201-995. Grades: ≥95%. CAS No. 760176-26-9. Molecular formula: C49H66N10O10S2·C2H4O2. Mole weight: 1079.3. | |
| OD1 | OD1 is a rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator. It exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5. OD1 can induce spontaneous pain in vivo. Synonyms: OD1; OD 1; OD-1. Grades: ≥95% by HPLC. Molecular formula: C308H466N90O95S8. Mole weight: 7206.1. | |
| Odapipam | Odapipam is a potent dopamine D1 antagonist. Synonyms: NNC 756; (5S)-8-chloro-5-(2,3-dihydro-1-benzofuran-7-yl)-3-methyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol. Grades: 99%. CAS No. 131796-63-9. Molecular formula: C19H20ClNO2. Mole weight: 329.82. | |
| Odelepran | Odelepran is a opioid receptor antagonist. It is used for the treatment of alcohol dependence. It was developed by Lilly and was in clinical phase 2 trial, but now it is terminated. Uses: Odelepran is used for the treatment of alcohol dependence. Synonyms: LY2196044; LY 2196044; LY-2196044; Odelepran; 6-[2-Fluoro-4-[[2- (oxan-4-yl) ethylamino]methyl]phenoxy]pyridine-3-carboxamide. Grades: 98%. CAS No. 676501-25-0. Molecular formula: C20H24FN3O3. Mole weight: 373.43. | |
| O-desmethyl Mebeverine alcohol hydrochloride | O-desmethyl Mebeverine alcohol hydrochloride, a metabolite of Mebeverine, is a potent inhibitor of α1 repector, causing relaxation of the gastrointestinal tract. Synonyms: 4-[2-[ethyl(4-hydroxybutyl)amino]propyl]phenol; hydrochloride; O-desmethyl Mebeverine alcohol (hydrochloride). CAS No. 856620-39-8. Molecular formula: C15H26ClNO2. Mole weight: 287.83. | |
| OF-1 | OF-1 is the potent and selective BRPF (BRomodomain and PHD Finger containing) inhibitor with Kd values 100 nM, 500 nM, and 2.4 μM for BRPF1B, BRPF2, and BRPF3, respectively. Selectivity against other bromodomains is very good, in general >100-fold. OF-1 increases thermal stability in the cellular thermal shift assay (CETSA) of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. Synonyms: SGC OF-1; SGC OF 1; SGC OF1; SGCOF1; SGC-OF-1; 4-bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methyl-benzenesulfonamide; OF-1; OF1; OF 1. CAS No. 919973-83-4. Molecular formula: C17H18BrN3O4S. Mole weight: 440.31. | |
| OL135 | OL135 is a CNS penetrant, highly potent and selective reversible inhibitor of FAAH. It exhibits analgesic pharmacology in various animal models without the motor impairment associated with direct CB1 agonism. It increases the analgesic and hypothermic activity of anandamide. Uses: Ol135 is used as an analgesic drug. Synonyms: OL-135;1-Oxo-1-[5-(2-pyridyl)oxazol-2-yl]-7-phenylheptane;7-Phenyl-1-[5-(2-pyridinyl)-2-oxazolyl]-1-heptanone;7-Phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one. Grades: 98%. CAS No. 681135-77-3. Molecular formula: C21H22N2O2. Mole weight: 334.42. | |
| OLDA | OLDA is a vanilloid TRPV1 (VR1) receptor agonist with EC50 value of 36 nM at hVR1. OLDA is also a 5-lipoxygenase inhibitor with IC50 value of 7.5 nM. Synonyms: (9Z)-N-[2-(3,4-Dihydroxyphenyl)ethyl]-9-octadecenamide. Grades: ≥99% by HPLC. CAS No. 105955-11-1. Molecular formula: C26H43NO3. Mole weight: 417.63. | |
| Oleanolic acid acrylate | Oleanolic acid acrylate (OAA) is an agonist of 5-HT1A receptor displaying antidepressant activity. It also acts as an inhibitor of MAO-A over MAO-B. Grades: ≥95%. CAS No. 1975976-24-9. Molecular formula: C33H50O4. Mole weight: 510.75. | |
| Oleoyl ethyl amide | Oleoyl ethyl amide is a fatty acid amide hydrolase (FAAH) inhibitor with potential analgesic and anxiolytic activity. It altered sensory urodynamic parameters and reduced bladder overactivity in female rats. Synonyms: OEtA; N-Ethyloleamide; (1Z)-N-Ethyloctadec-9-enimidate. Grades: ≥98%. CAS No. 85075-82-7. Molecular formula: C20H39NO. Mole weight: 309.5. | |
| Oleoyl oxazolopyridine | Oleoyl oxazolopyridine is a potent inhibitor of fatty acid amide hydrolase (FAAH) with Ki values of 1.3 and 2.3 nM for the human and rat enzymes, respectively. It is approximately 35-fold more potent than oleyl trifluoromethyl ketone when assayed under the same conditions. Synonyms: CAY10400; (Z)-1-([1,3]oxazolo[4,5-b]pyridin-2-yl)octadec-9-en-1-one. Grades: ≥98%. CAS No. 288862-58-8. Molecular formula: C24H36N2O2. Mole weight: 384.6. | |
| Oleoyl serinol | Oleoyl serinol is an analog of ceramide that acts as an agonist of the cannabinoid receptor GPR119. It has been found to stimulate migration of neural progenitors (NPs) in scratch (wounding) migration assays. It eliminates mouse and human Oct-4(+)/PAR-4(+) cells, preventing teratoma formation, and enriching the embryoid body-derived cells (EBCs) for cells that undergo neural differentiation after transplantation. Synonyms: N-Oleoyl serinol; S-18; (Z)-N-(1,3-dihydroxypropan-2-yl)octadec-9-enamide. Grades: ≥98%. CAS No. 72809-08-6. Molecular formula: C21H41NO3. Mole weight: 355.6. | |
| Oleoyl serotonin | Oleoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, which is a dual antagonist of FAAH/TRPV1 channel. Oleoyl serotonin inhibits capsaicin-induced TRPV1 channel activation (IC50 = 2.57 μM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC50 > 50 μM). Synonyms: (9Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]octadec-9-enamide; N-(2-(5-Hydroxy-1H-indol-3-yl)ethyl)-9Z-octadecenamide. Grades: ≥98%. CAS No. 1002100-44-8. Molecular formula: C28H44N2O2. Mole weight: 440.7. | |
| Oleylethanolamide | Oleylethanolamide is an endogenous agonist for PPARα with an EC50 value of 120 nM in a transactivation assay. Oleylethanolamide is also a selective GPR55 agonist with EC50 value of 120 μM. It is involved in peripheral regulation of feeding. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: (9Z)-N-(2-Hydroxyethyl)-9-octadecenamide. Grades: ≥99% by HPLC. CAS No. 111-58-0. Molecular formula: C20H39NO2. Mole weight: 325.53. | |
| Oleyloxyethyl phosphorylcholine | Oleyloxyethyl phosphorylcholine is an inhibitor of PLA2 with IC50 value of 6.2 μM for porcine pancreatic PLA2. Synonyms: 2-Oleyloxyethyl 2-trimethylammonioethyl phosphate; 2-[(Z)-octadec-9-enoxy]ethyl 2-(trimethylazaniumyl)ethyl phosphate. Grades: ≥98%. CAS No. 84601-19-4. Molecular formula: C25H52NO5P. Mole weight: 477.7. | |
| Oleyl trifluoromethyl ketone | Oleyl trifluoromethyl ketone is a potent inhibitor of FAAH, in both human and rat. Synonyms: Heptadecyl trifluoromethyl ketone; OTK; (Z)-1,1,1-Trifluoro-nonadec-10-en-2-one. Grades: ≥98%. CAS No. 177987-23-4. Molecular formula: C19H33F3O. Mole weight: 334.5. | |
| Olinone | Olinone, a pyridoindol derivative, has been found to be an BET Bromodomain inhibitor and could be probably useful in sorts of biological studies. Synonyms: Olinone; SCHEMBL16771423; N-[4-(1-Oxo-1,2,3,4-Tetrahydro-5h-Pyrido[4,3-B]indol-5-Yl)butyl]acetamide. Grades: 98%. CAS No. 1770789-37-1. Molecular formula: C17H21N3O2. Mole weight: 299.37. | |
| Olopatadine | This active molecular is an antihistamine, anticholinergic and mast cell stabilizer. Olopatadine blocks the action of endogenous histamine. It is used to treat itching associated with allergic conjunctivitis (eye allergies). In Dec 2014, Alcon Research planed a phase III trial for Allergic conjunctivitis in China.In Jan 2015,Registered for Allergic conjunctivitis in USA was completed (Ophthalmic, 0.7%). In Oct 2015, Alcon Research completeD phase III trial in Allergic conjunctivitis in China. Uses: Antiallergic; antihistaminic;for the treatment of ocular itching associated with allergic conjunctivitis. Synonyms: (Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid; 11-[(Z)-3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid; Opatanol; Pataday; Patanol; KW-4679, KW 4679; KW4679; KW-4943A. Grades: 98%. CAS No. 113806-05-6. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| Olprinone | Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. Uses: Cardiotonic agents. Synonyms: Olprinone; 106730-54-5; loprinone; Olprinone [INN]5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile. Grades: >98%. CAS No. 106730-54-5. Molecular formula: C14H10N4O. Mole weight: 250.26. | |
| Olprinone Hydrochloride | Olprinone is a selective phosphodiesterase 3 (PDE3) inhibitor. Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Synonyms: 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride, Loprinone hydrochloride. Grades: >98%. CAS No. 119615-63-3. Molecular formula: C14H11ClN4O. Mole weight: 286.72. | |
| Olsalazine | Olsalazine, a kind of colchicum alkaloid, has been found to be an anti-inflammatory agent and could be used against inflammatory bowel disease and ulcerative colitis. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: Olsalazine; Dipentium; Salicylic acid; ; 3, 3'-azobis(6-hydroxy-benzoicaci; 3, 3'-azobis(6-hydroxybenzoicacid); 5, 5'-azobis(salicylicacid); azodisal; c.i.mordantyellow5; Ph-CJ-91B; 4, 4'-Dihydroxyazobenzene-3, 3'-dicarboxylic acid. Grades: 98%. CAS No. 15722-48-2. Molecular formula: C14H10N2O6. Mole weight: 302.24. | |
| Oltipraz | Oltipraz, a promising cancer chemopreventive agent, is a bifunctional inducer, modulating both phase I and II drug-metabolizing enzymes to enhance carcinogen detoxification. Uses: Anticarcinogenic agents. Synonyms: CD1400; CD 1400; CD-1400. Grades: >98%. CAS No. 64224-21-1. Molecular formula: C8H6N2S3. Mole weight: 226.33. | |
| Olutasidenib | Olutasidenib is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor used to treat acute myeloid leukemia. Synonyms: FT-2102; FT2102. CAS No. 1887014-12-1. Molecular formula: C18H15ClN4O2. Mole weight: 354.8. | |
| Ombitasvir | Ombitasvir, a NS5A inhibitor, could be effective in the treatment of HCV as an antiviral agent. IC50: 14 pM and 5 pM (EC50) for genotype 1a-H77 and 1b-Con1 respectively. Uses: Ombitasvir is a ns5a inhibitor that could be effective in the treatment of hcv as an antiviral agent. Synonyms: ABT-267; ABT267; ABT 267; Ombitasvir; Viekira Pak; Ombitasvir(ABT-267); CHEBI:85183. Grades: 98%. CAS No. 1258226-87-7. Molecular formula: C50H67N7O8. Mole weight: 894.11. | |
| ω-Agatoxin TK | ω-Agatoxin TK is a kind of toxin found in the venom of the funnel web spider. It is a selective and potent blocker of CaV2.1 P-type and Q-type calcium channels. It is selective for P/Q-type Ca2+ channel, but shows little or no activity at N-type, or T-type calcium channels. So it is used to differentiate the types of calcium channel active during various physiological processes. Synonyms: omega-Agatoxin TK; Agatoxin IVB; ω-Aga-TK. CAS No. 158484-42-5. Molecular formula: C215H337N65O70S10. Mole weight: 5273.02. | |
| Omidenepag | This active molecular is a prostaglandin receptor agonist and detailed information has not been published yet. Synonyms: Omidenepag; UR-7276; UR 7276; UR7276; (6-((N-(4-(1H-pyrazol-1-yl)benzyl)pyridine-3-sulfonamido)methyl)pyridin-2-yl)glycine. Grades: 98%. CAS No. 1187451-41-7. Molecular formula: C23H22N6O4S. Mole weight: 478.53. | |
| Omipalisib | Omipalisib, also known as GSK2126458, is asmall-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity. PI3K inhibitor GSK2126458 binds to and inhibits PI3K in the PI3K/mTOR signaling pathway, which may trigger the translocation of cytosolic Bax to the mitochondrial outer membrane, increasing mitochondrial membrane permeability and inducing apoptotic cell death. Bax is a member of the proapoptotic Bcl2 family of proteins. PI3K, often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival. Synonyms: GSK-2126458; GSK2126458; GSK 2126458; Omipalisib. CAS No. 1086062-66-9. Molecular formula: C25H17F2N5O3S. Mole weight: 505.5. | |
| ON1231320 | ON1231320, also known as GBO-006, was found to be a specific Polo like kinase 2 (PLK2) inhibitor when profiled against a panel of 288 wild-type, 55 mutant and 12 special kinases. In vitro testing revealed that ON1231320 is a selective inhibitor of PLK2 with no inhibitory activity against PLK1, PLK3 and PLK4. Synonyms: 2-((1H-indol-5-yl)amino)-6-((2,4-difluorophenyl)sulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one; ON1231320; ON-1231320; ON 1231320; GBO-006; GBO006; GBO 006. CAS No. 131247-39-8. Molecular formula: C22H15F2N5O3S. Mole weight: 467.45. | |
| ON123300 | ON123300, a dihydropyrido[2,3-d]pyrimidine derivative, has been found to be an effective multikinase inhibitor that could be probably used against brain tumor and mantle cell lymphomas. It is still under preclinical trials in Colorectal cancer. IC50: 3.8. Uses: On123300 has been found to be an effective multikinase inhibitor that could be probably used against brain tumor and mantle cell lymphomas. Synonyms: UNII-QJ8RO3296G; QJ8RO3296G; CHEMBL3115681; ON-123300; ON 123300; ON123300. SCHEMBL10050883; BDBM50447512. Grades: 98%. CAS No. 1357470-29-1. Molecular formula: C24H27N7O. Mole weight: 429.52. | |
| ON 146040 | ON 146040 was highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1,000 nM range. In biochemical testing, ON 146040 inhibited PI3K α/δ isoforms (IC50 ? 14 and 20 nM, respectively) without having a major effect on β/γ isoforms (IC50 ? 3 and 1 μM, respectively). ON 146040 was also found to inhibit Abl1 and several mutant versions of this kinase (IC50 < 150 nM), although the compound was not found to be active against the T315I mutant. Following treatment with ON 146040, STAT3 and STAT5 phosphorylation were down-regulated in leukemia and myeloma cells. Synonyms: ON-146040; ON146040. Grades:>98%. CAS No. 1404231-34-0. Molecular formula: C24H23N7O3S. Mole weight: 489.55. | |
| Ondansetron Hydrochloride Dihydrate | Ondansetron hydrochloride dihydrate is a specific and competitive antagonist of serotonin 5-HT3 receptor (Ki = 0.77 nM) with anxiolytic and neuroleptic activities. It can be used for the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, such as cisplatin. Uses: Serotonin 5-ht3 receptor antagonists. Synonyms: Zofran; GR 38032F; Ondansetron (hydrochloride dihydrate). Grades: 99.37 %. CAS No. 103639-04-9. Molecular formula: C18H19N3O.HCl.2H2O. Mole weight: 365.85. | |
| Ono 3403 | Ono 3403, a derivative of camostat mesilate and has a higher protease-inhibitory activity, is a synthetic serine protease inhibitor that inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock. Synonyms: (4-carbamimidoylphenyl) 4-[(E)-3-[(2-ethoxy-2-oxoethyl)-prop-2-enylamino]-2-methyl-3-oxoprop-1-enyl]benzoate;methanesulfonic acid; ethyl N-allyl-N- (2-methyl-3- (4- (4-amidinophenoxycarbonyl) phenyl) propenoyl) aminoacetate methanesulfonate; ONO 3403; ONO-3403; ONO 3403. Grades: >98%. CAS No. 181586-07-2. Molecular formula: C2H31N3O8S. Mole weight: 545.60. | |
| ONO-4057 | ONO-4057 is a leukotriene B4 receptor antagonist originated by Ono Pharmaceutical. ONO-4057 is an Immunologic Factor and Immunosuppressive Agent. Clinical trials for the treatment of Behcet's syndrome, Gastritis and Ulcerative colitis was discontinued. Uses: Behcet's syndrome; gastritis; ulcerative colitis. Synonyms: ONO-4057; ONO4057; ONO 4057; Ono-LB-457; Ono LB 457; OnoLB457; Ono-LB 457; (E)-5-(2-(2-carboxyethyl)-3-((6-(4-methoxyphenyl)hex-5-en-1-yl)oxy)phenoxy)pentanoic acid. Grades: 98%. CAS No. 134578-96-4. Molecular formula: C27H34O7. Mole weight: 470.56. | |
| ONO-4059 analogue | ONO-4059 analogue is an analogue of ONO-4059, which is a highly potent and selective oral BTK inhibitor with IC50 of 23.9 nM. Phase 1. Synonyms: ONO-WG-307; ONO-4059 analogue; ONO 4059 analogue; ONO4059 analogue. Grades: 98%. CAS No. 1351635-67-0. Molecular formula: C25H24N6O3. Mole weight: 456.5. | |
| ONO 4817 | ONO 4817 is a broad spectrum matrix metalloproteinase (MMPs) inhibitor. It shows antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. Synonyms: ONO 4817; ONO4817; ONO-4817; N-[(1S,3S)-1-[(Ethoxymethoxy)methyl]-4-(hydroxyamino)-3-methyl-4-oxobutyl]-4-phenoxybenzamide. Grades: ≥99% by HPLC. CAS No. 223472-31-9. Molecular formula: C22H28N2O6. Mole weight: 416.47. | |
| ONO-5334 | NO-5334 is cathepsin K inhibitor Ki values of 0.1 nM for human. It can improve bone strength by preferentially increasing cortical bone mass in ovariectomized rats. ONO-5334 can also inhibit N-terminal and C-terminal collagen crosslinks in serum and urine in postmenopausal women. In Feb 2012, Phase-II for Osteoporosis in European Union was discontinued. Uses: Osteoporosis. Synonyms: ONO-5334; ONO 5334; ONO5334. N-((S)-3-(2-((R,Z)-3,4-dimethylthiazolidin-2-ylidene)hydrazinyl)-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl)cycloheptanecarboxamide. Grades: 98%. CAS No. 868273-90-9. Molecular formula: C21H34N4O4S. Mole weight: 438.59. | |
| ONO-8711 | ONO-8711 is a potent and selective competitive antagonist of the EP1 receptor. It reduces the risk of breast cancer, and inhibits its multiplicity and volume. Synonyms: ONO 8711; ONO8711; GTPL1920; (Z)-6-[(2R,3S)-3-[[(4-chloro-2-methylphenyl)sulfonylamino]methyl]-2-bicyclo[2.2.2]octanyl]hex-5-enoic acid. Grades: ≥98%. CAS No. 216158-34-8. Molecular formula: C22H30ClNO4S. Mole weight: 440. | |
| ONO 8711 dicyclohexyl amine salt | ONO 8711 dicyclohexyl amine salt is a selective and competitive prostaglandin E (PGE) receptor EP1 antagonist with chemopreventive activity. It suppresses tumor incidence and proliferation in mouse models of cancer. Uses: Tumor suppressant. Synonyms: ONO 8711 dicyclohexyl amine salt; ONO8711 dicyclohexyl amine salt; ONO-8711 dicyclohexyl amine salt; dicyclohexylamine (Z) -6- ( (1S, 2R, 3R, 4S) -3- ( (4-chloro-2-methylphenylsulfonamido) methyl) bicyclo[2. 2. 2]octan-2-yl) hex-5-enoate. Grades: 98%. Molecular formula: C22H30ClNO4S.C12H23N. Mole weight: 621.31. | |
| Ononetin | Ononetin is a TRPM3 channel blocker with IC50 value of 300 nM. Synonyms: 1-(2,4-Dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone. Grades: ≥98% by HPLC. CAS No. 487-49-0. Molecular formula: C15H14O4. Mole weight: 258.27. | |
| ONO-RS-082 | ONO-RS-082 is a reversible inhibitor of PLA2 and epinephrine. It has been shown to inhibit the substance P (SP)-induced histamine release in a concentration-dependent manner. Synonyms: 4-Chloro-2-[[(2E)-1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]benzoic Acid; (E)-4-chloro-2-[[1-oxo-3-(4-pentylphenyl)-2-propenyl]amino]benzoic Acid. Grades: ≥98%. CAS No. 99754-06-0. Molecular formula: C21H22ClNO3. Mole weight: 371.86. | |
| Ono-RS-347 | Ono-RS-347 is an SRS-A antagonist and a new leukotriene antagonists. Synonyms: Ono-RS-347; Ono RS-347; Ono RS 347; Ono-RS 347; 8-(4-(4-Phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)benzo-1,4-dioxane;4-(4-Phenylbutoxy)-N-[3-(2H-tetrazol-5-yl)-2,3-dihydro-1,4-benzodioxin-5-yl]benzamide;N-(3-(1H-tetrazol-5-yl)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-4-(4-phenylbutoxy)benzamide. Grades: >98 %. CAS No. 103176-67-6. Molecular formula: C26H25N5O4. Mole weight: 471.51. | |
| ONX-0914 | ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders, such as rheumatoid arthritis, inflammatory bowel disease and lupus. ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. Recent evidence suggests that the immunoproteasome regulates the production of several inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-6 (IL-6), IL-17, and IL-23. In preclinical models of rhematoid arthritis and lupus, ONX 0914 blocked progression of these diseases at well-tolerated doses. Preclinical studies are underway to evaluate the potential of ONX 0914 in the treatment of a range of autoimmune disorders. Uses: Proteasome inhibitors. Synonyms: ONX 0914; ONX0914; ONX-0914; PR957; PR-957; PR 957. Grades: >98%. CAS No. 960374-59-8. Molecular formula: C31H40N4O7. Mole weight: 580.6719. | |
| OPC 13463 | OPC 13463 is one of the metabolites of pranidipine. Pranidipine is a long acting calcium channel antagonist of the dihydropyridine group. Synonyms: 5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)pyridine-3-carboxylate;MP2689; MP-2689; MP 2689; OPC13463; OPC-13463; OPC 13463. Grades: 98%. CAS No. 73372-63-1. Molecular formula: C16H13N2O6-. Mole weight: 329.29. | |
| OPC 21268 | OPC-21268 is a vasopressin V1 receptor antagonist with IC50 value of 0.4 μM. Uses: Antidiuretic hormone receptor antagonists. Synonyms: OPC-21268; OPC21268; OPC 21268; N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide. Grades: ≥98% by HPLC. CAS No. 131631-89-5. Molecular formula: C26H31N3O4. Mole weight: 449.54. | |
| OPC 31260 hydrochloride | OPC 31260 is a Vasopressin receptor antagonist marketed by Otsuka. It is a benzazepine derivative that antagonizes the binding of arginine vasopressin (AVP) to vasopressin receptors located in the liver (V1; IC50 = 1.2 μM) and kidney (V2; IC50 = 14 nM). In Japan, OPC 31260 was approved in October 2006 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH) due to ADH producing tumors. Uses: Hyponatraemia. Synonyms: OPC 31260 hydrochloride; OPC31260 hydrochloride; OPC-31260 hydrochloride; N-(4-(5-(dimethylamino)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-2-methylbenzamide hydrochloride;OPC31260. Grades: 98%. CAS No. 138470-70-9. Molecular formula: C27H30ClN3O2. Mole weight: 464.01. | |
| Optovin | Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-type zebrafish (EC50 = 2 μM). Synonyms: Optovin; 348575-88-2; Oprovin; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-2-thioxo-4-thiazolidinone; SCHEMBL14305788; 5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one; CHEBI:137470; HMS3886J04; 5-{[2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl]methylidene}-2-sulfanylidene-1,3-thiazolidin-4-one; YNA57588; CCG-14653; MFCD02219276; AKOS000337708; BIM-0018214.P001; S8073; SW219786-1; AB00104090-01; SR-01000230413; SR-01000230413-1. Grades: >98%. CAS No. 348575-88-2. Molecular formula: C15H13N3OS2. Mole weight: 315.41. | |
| Orbifloxacin | Orbifloxacin is a third generation of fluoroquinolone that exhibits increased antibacterial activity against the Enterobacteriaceae, gram-negative and gram-positive bacteria, anaerobes, and mycobacteria. Grades: >98%. CAS No. 113617-63-3. Molecular formula: C19H20F3N3O3. Mole weight: 395.38. | |
| Orciprenaline | Orciprenaline is a moderately selective beta-adrenergic agonist used in the treatment of asthma and bronchospasms. It stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. It is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP. It was developed by Boehringer-Ingelheim and has been withdraw from the market. Uses: Orciprenaline is used in the treatment of asthma and bronchospasms. Synonyms: Metaproterenol;Alupent;Metaprel;5-[1-Hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,3-diol;Astmopent;1-(3,5-dihydroxyphenyl)-2-isopropylaminoethanol;1,3-Benzenediol, 5-1-hydroxy-2-(1-methylethyl)aminoethyl-;3,5-Dihydroxy-a-[(isopropylamino)methyl]benzyl alco. Grades: 95%. CAS No. 586-06-1. Molecular formula: C11H17NO3. Mole weight: 211.26. | |
| Ordopidine | Ordopidine is a dopaminergic stabilizer. It can inhibit psychostimulant-induced hyperactivity and stimulate behaviour in states of hypoactivity. In May 2016, Phase-I clinical trials in Parkinson's disease in Germany was discontinued. Uses: Parkinson's disease. Synonyms: ACR 325; ACR325; ACR-325; 1-Ethyl-4-(2-fluoro-3-(methylsulfonyl)phenyl)piperidine. Grades: 98%. CAS No. 871351-60-9. Molecular formula: C14H20FNO2S. Mole weight: 285.38. | |
| Orenetide | Orenetide is a GABA receptor antagonist. Synonyms: L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-proline. CAS No. 1124168-43-9. Molecular formula: C26H47N9O7. Mole weight: 597.7. | |
| Orexin 2 Receptor Agonist | N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide is an orexin 2 receptor agonist that is potentially for the treatment of narcolepsy. Synonyms: MDK-5220; MDK 5220; MDK5220. Orexin2 receptor agonist; CHEMBL3623075; N- [2- [3- [ [5- [3- (dimethylcarbamoyl) phenyl] -2-methoxyphenyl] sulfonylamino] anilino] ethyl] -3-methylbenzamide; GTPL9305; SCHEMBL18138813. Grades: ≥98%. CAS No. 1796565-52-0. Molecular formula: C32H34N4O5S. Mole weight: 586.707. | |
| Org 12962 hydrochloride | Org 12962 hydrochloride is a 5-HT2C receptor agonist with pEC50 value of 7.01. It shows antiaversive effects in the anxiety models in rats. Synonyms: Org 12962 hydrochloride; Org12962 hydrochloride; Org-12962 hydrochloride; 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride. Grades: ≥99% by HPLC. CAS No. 210821-63-9. Molecular formula: C10H11ClF3N3.HCl. Mole weight: 302.12. | |
| Org 20599 | Org 20599 is an anesthetic steroid that has a modulatory effect on GABAA receptors. Org 20599 is a potential drug for the treatment of migraines and headaches. Synonyms: Org 20599 free base; Pregnan-20-one, 21-chloro-3-hydroxy-2-(4-morpholinyl)-, (2β,3α,5α)-; (2β,3α,5α)-21-Chloro-3-hydroxy-2-(4-morpholinyl)pregnan-20-one; 2-chloro-1-((2S,3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethan-1-one. Grades: ≥95% by HPLC. CAS No. 156685-94-8. Molecular formula: C25H40ClNO3. Mole weight: 438.04. | |
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