BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Piboserod | Piboserod is a highly and potent selective 5-HT4 receptor antagonist which as been studied in vitro as well as in vivo as a pharmacological tool to evaluate the pathophysiological role of the 5-HT4 receptor in human gastrointestinal pathophysiology. Synonyms: N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide Piboserod UNII-4UQ3S81B25 SB-207266 152811-62-6 SB207256 SB 207266 N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide Pibosero. Grades: 95%. CAS No. 152811-62-6. Molecular formula: C22H31N3O2. Mole weight: 369.51. |  |
| Piboserod hydrochloride | Piboserod hydrochloride is a selective 5-HT4 antagonist. Synonyms: Piboserod HCl; N-[(1-butylpiperidin-4-yl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indole-10-carboxamide hydrochloride. Grades: 99%. CAS No. 178273-87-5. Molecular formula: C22H31N3O2.HCl. Mole weight: 405.96. | |
| Pibrentasvir | Pibrentasvir is an antiviral agent that inhibits HCV non-structural protein 5A (NS5A). It inhibits HCV RNA replication and viron assembly. In combination with glecaprevir, a HCV NS3/4A protease inhibitor, pibrentasvir is used to treat patients with HCV infections who experienced therapeutic failure from other NS5A inhibitors. Grades: ≥98%. CAS No. 1353900-92-1. Molecular formula: C57H65F5N10O8. Mole weight: 1113.18. | |
| Picfeltarraenin IA | Picfeltarraenin IA is a naturally occurring triterpenoid glycoside that acts as an AChE inhibitior. It also inhibits PI3K and EGFR. CAS No. 97230-47-2. Molecular formula: C41H62O13. Mole weight: 762.92. | |
| Piclamilast | Piclamilast is a potent and selective phosphodiesterase-4 (PDE4) inhibitor (IC50 = 1 nM at PDE4 from human neutrophils) with >19,000-fold selectivity over other PDE isoenzymes. Uses: Phosphodiesterase 4 inhibitors. Synonyms: Piclamilast; RP-73401; RP 73-401; RP 73401; RP 73 401; RP73401; RP 73401; 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide; N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide. Grades: ≥99% by HPLC. CAS No. 144035-83-6. Molecular formula: C18H18Cl2N2O3. Mole weight: 381.25. | |
| Picolinamide | Picolinamide acts as an inhibitor of poly (ADP-ribose) synthetase (PARP) of nuclei from rat pancreatic islet cells. Synonyms: pyridine-2-carboxamide. CAS No. 1452-77-3. Molecular formula: C6H6N2O. Mole weight: 122.12. | |
| picropodophyllin | Picropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis. IGF1R, a receptor tyrosine kinase overexpressed in a variety of human cancers, plays a critical role in the growth and survival of many types of cancer cells. Synonyms: AXL1717; AX-L1717; AXL 1717; PPP; Picropodophyllotoxin. Grades: >98%. CAS No. 477-47-4. Molecular formula: C22H22O8. Mole weight: 414.41. | |
| Pidilizumab | A humanized, immunoglobulin (Ig) G1 monoclonal antibody directed against human inhibitory receptor programmed cell death 1 (PD-1; PDCD1), with potential immune checkpoint inhibitory and antineoplastic activities. Pidilizumab binds to PD-1 and blocks the interaction between PD-1 and its ligands, PD-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2). This prevents the activation of PD-1 and its downstream signaling pathways. This may restore immune function through the activation of natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. PD-1, an inhibitory receptor belonging to the B7-receptor family expressed on activated T-lymphocytes, B-cells and NK cells, negatively regulates T-cell activation and effector function when activated by its ligands; it plays an important role in tumor evasion from host immunity. Synonyms: CT-011; MDV 9300; CT 011; MDV9300; CT011; MDV-9300. CAS No. 1036730-42-3. | |
| Pifithrin-β | Pifithrin-β is a potent p53 inhibitor (IC50=23 uM) in an antiproliferative, showing a conformation similar to those of the prototypical AhR ligand β-naphthoflavone. Uses: A cell-permeable and very stable analog of pifithrin-α with similar biological function, but with reduced cytotoxicity. Synonyms: Cyclic Pifithrin-α; 2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole. Grades: ≥98%. CAS No. 60477-34-1. Molecular formula: C16H16N2S.HBr. Mole weight: 349.29. | |
| PIK-294 | PIK-294 is a potent PI3K inhibitor. Synonyms: PIK-294; PIK 294; PIK294. Grades: 0.98. CAS No. 900185-02-6. Molecular formula: C28H23N7O2. Mole weight: 489.539. | |
| PIK-75 | PIK-75 was developed as part of a PI 3-kinase drug discovery program. PIK75 attenuates insulin stimulation of Akt/PKB in a range of cell types at 100 nM. The compound has been reported to block growth of a range of cell lines with an IC50 value in the region of 50 nM. In vivo studies have shown that PIK-75, administered at 50 mg/kg, inhibited the growth of HeLa cell xenografts in mice models. Uses: Pi 3-kinase drug (ic50 values are 5.8, 76 nm and 1.3 μm at pi 3-kinase p110α, pi 3-kinase p110γ and pi 3-kinase p110β respectively); attenuates insulin stimulation of akt/pkb in a range of cell types at 100 nm; in vivo: studies have shown that pik-75, administered at 50 mg/kg, inhibited the growth of hela cell xenografts in mice models. Synonyms: (E)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide; PIK75; PIK-75; PIK 75. CAS No. 372196-67-3. Molecular formula: C16H14BrN5O4S. Mole weight: 452.30. | |
| PIK-90 | PIK-90 is a potent PI3K inhibitor. Synonyms: PIK-90; PIK90; PIK 90. Grades: 0.98. CAS No. 677338-12-4. Molecular formula: C18H17N5O3. Mole weight: 351.366. | |
| PIK-93 | PIK-93 is a potent PI3K inhibitor. Synonyms: PIK-93; PIK 93; PIK93. Grades: 0.98. CAS No. 593960-11-3. Molecular formula: C14H16ClN3O4S2. Mole weight: 389.869. | |
| Pilocarpine Hydrochloride | Cas No. 54-71-7. | |
| Pimasertib | Pimasertib, also known as AS703026, SAR245509, MSC1936369B, is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor AS703026 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. Synonyms: SAR245509; SAR-245509; SAR 245509; MSC1936369B; AS-703026; AS 703026; AS703026. Grades: 0.98. CAS No. 1236699-92-5. Molecular formula: C15H15FIN3O3. Mole weight: 431.206. | |
| Pimethixene | Pimethixene, also called as BP 400 or Calmixène, with antihistamine and anticholinergic properties it treats hyperactivity, anxiety, sleep disorders, and allergy. Synonyms: 1-methyl-4-thioxanthen-9-ylidenepiperidine1-methyl-4-thioxanthen-9-ylidenepiperidineBP 400; BP400; BP-400Calmixènepimethixene. CAS No. 314-03-4. Molecular formula: C19H19NS. Mole weight: 293.432. | |
| Pimobendan hydrochloride | Pimobendan hydrochloride is a selective inhibitor of PDE3. It exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). It shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. It also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. It suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. Synonyms: Vetmedin hydrochloride; Acardi hydrochloride. Grades: >98%. CAS No. 77469-98-8. Molecular formula: C19H19ClN4O2. Mole weight: 370.83. | |
| Pinaverium bromide | Pinaverium bromide is a calcium channel blocker and can be used as an antispasmodic. Synonyms: Icosapentaenoic acid; Dicetel; 4-[(2-bromo-4, 5-dimethoxyphenyl)methyl]-4-[2-[2-(6, 6-dimethyl-2-bicyclo[3. 1. 1]heptanyl)ethoxy]ethyl]morpholin-4-ium bromide. CAS No. 53251-94-8. Molecular formula: C26H41Br2NO4. Mole weight: 591.42. | |
| p-Iodo-clonidine hydrochloride | p-Iodo-clonidine is a partial antihypertensive α2-adrenergic receptor agonist. It potentiates platelet aggregation by ADP and inhibits epinephrine-induced aggregation. Uses: Affinity labels. Synonyms: p-Iodoclonidine hydrochloride; 2-[(2,6-Dichloro-4-iodophenyl)imino]imidazoline hydrochloride; N-(2,6-dichloro-4-iodophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride. Grades: ≥98%. CAS No. 108294-57-1. Molecular formula: C9H8Cl2IN3·HCl. Mole weight: 392.5. | |
| Pioglitazone potassium salt | Pioglitazone is a PPARγ agonist (EC50 = ~500-600 nM) with selectivity for PPARγ over PPAR&alpha. It has been used as a medication indicated for the treatment of diabetes mellitus type 2, It works by lowering insulin resistance thus reducing glucose level. Synonyms: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidin-3-ide-2,4-dione potassium salt. Grades: ≥98%. CAS No. 1266523-09-4. Molecular formula: C19H19N2O3S·K. Mole weight: 394.53. | |
| Pipecuronium | A nondepolarizing neuromuscular blocking agent that inhibits neuromuscular transmission by competing with acetylcholine for the cholinergic receptors of the motor end plate, thereby reducing the response of the end plate to acetylcholine. It has been used as a muscle relaxant during anesthesia and surgical procedures. Synonyms: Pipecurium; Arduan. CAS No. 68399-58-6. Molecular formula: C35H62N4O4. Mole weight: 602.89. | |
| Pipendoxifene hydrochloride | Pipendoxifene hydrochloride is the hydrochloride salt of Pipendoxifene, which is a selective estrogen receptor modulator (SERM). Synonyms: 2-(4-hydroxyphenyl)-3-methyl-1-[[4-(2-piperidin-1-ylethoxy)phenyl]methyl]indol-5-ol;hydrochloride; Pipendoxifene (hydrochloride). CAS No. 245124-69-0. Molecular formula: C29H33ClN2O3. Mole weight: 493.04. | |
| Pipenzolate | Pipenzolate, a muscarinic receptor antagonist, commonly existed as bromide salt form and could be used as a spasmolytic and could probably effective in aid therapy of Alzheimer's disease. Uses: Pipenzolate is a muscarinic receptor antagonist and commonly existed as bromide salt form and could be used as a spasmolytic and could probably effective in aid therapy of alzheimer's disease. Synonyms: pipenzolate;Pipenzolonum;EINECS236-748-1;BRN1506094; BRN 1506094; BRN-1506094; 13473-38-6;Piperidinium,1-ethyl-3-hydroxy-1-methyl-,benzilate(ester). Grades: 95%. CAS No. 13473-38-6. Molecular formula: C22H28NO3+. Mole weight: 354.46. | |
| Pipenzolate bromide | Pipenzolate bromide, a muscarinic receptor antagonist, was once considered as a spasmolytic. Uses: Pipenzolate bromide is a muscarinic receptor antagonist that was once considered as a spasmolytic. Synonyms: NSC 4347; NSC-4347; NSC4347; PIPENZOLATE BROMIDE; 1-ethyl-3-hydroxy-1-methyl-piperidiniumbromidebenzilate; 1-ethyl-3-piperidylbenzilatemethylbromide; benzilicacid, 1-ethyl-3-piperidylestermethylbromide; benzilicacid, esterwith1-ethyl-3-hydroxy-1-methylpiperidiniumbromide; jb-323; jb 323; jb323. Grades: 95%. CAS No. 125-51-9. Molecular formula: C22H28NO3.Br. Mole weight: 434.42. | |
| Pipequaline | Pipequaline is a non-selective GABAA receptor partial agonist that is potentially used as an anxiolytic drug of the nonbenzodiazepine class. It exhibits anxiolytic properties and very little sedative, amnestic or anticonvulsant effects. Currently pipequaline is only used for research. Uses: Pipequaline is a non-selective gabaa receptor partial agonist. Synonyms: Pipequalinum; Pipequalina; UNII-J3S205V4I2; PK-8165; 2-phenyl-4-(2-piperidin-4-ylethyl)quinoline. Grades: 0.95. CAS No. 77472-98-1. Molecular formula: C22H24N2. Mole weight: 316.448. | |
| Pipequaline HCl | | |
| Piperazine malate | An anthelmintic. Synonyms: 2-hydroxybutanedioic acid;piperazine; Piperazine DL-Malate; Piperazine (malate). CAS No. 14852-14-3. Molecular formula: C8H16N2O5. Mole weight: 220.22. | |
| Piperidine-MO-1 | A modulator of dopamine receptor. Synonyms: Piperidine, 1-ethyl-4-[2-fluoro-3-(methylsulfonyl)phenyl]-, hydrochloride; 1-ethyl-4-(2-fluoro-3-methylsulfonylphenyl)piperidine; hydrochloride; ordopidine hydrochloride. CAS No. 871351-61-0. Molecular formula: C14H21ClFNO2S. Mole weight: 321.84. | |
| Piperidolate hydrochloride | The hydrochloride salt form of Piperidolate which is an antimuscarinic and could restrain the abnormal activity caused by acetylcholine. Uses: The hydrochloride salt form of piperidolate which is an antimuscarinic and could restrain the abnormal activity caused by acetylcholine. Synonyms: Piperidolate hydrochloride; Dactil; Crapinon; NSC 4349; NSC4349; NSC-4349; Piperidolate HCl; 1-ethyl-3-piperidyldiphenyl-acetatehydrochloride;3-piperidinol, 1-ethyl-, diphenylacetate, hydrochloride;aceticacid, diphenyl-, 1-ethyl-3-piperidylester, hydrochloride;benzeneaceticacid, alpha-phenyl-, 1-ethyl-3-piperidinylester, hydrochloride;benzeneaceticacid, a. Grades: 95%. CAS No. 129-77-1. Molecular formula: C21H25NO2. Mole weight: 323.43. | |
| Piperonylbutoxide | Piperonyl butoxide works as an insecticide synergist. It is useful in inhibitng the insect microsomal enzyme detoxification activity and is always under the combination usage with other ingredients like pyrethroid, rotenone, pyrethrin and etc. Uses: Piperonyl butoxide works as an insecticide synergist mainly for pyrethroids and rotenone. Synonyms: 5-[2-(2-butoxyethoxy)ethoxymethyl]-6-propyl-1,3-benzodioxole. Grades: > 90 %. CAS No. 51-03-6. Molecular formula: C19H30O5. Mole weight: 338.44. | |
| Pirbuterol acetate | Pirbuterol acetate is a short-acting β2 adrenoreceptor agonist. It has bronchodilating action and is used as a bronchodilator. It is also used in the treatment of asthma as a breath-activated metered-dose inhaler. It was developed by Valeant and has been listed. Uses: Pirbuterol acetate has bronchodilating action and is used as a bronchodilator. it is also used in the treatment of asthma as a breath-activated metered-dose inhaler. Synonyms: Alpha-6-[(tert-butylamino)methyl]-3-hydroxypyridine-2,6-dimethanol monoacetate;(RS)-2-(tert-Butylamino)-1-(6-hydroxymethyl-5-hydroxy-2-pyridyl)ethanol acetate salt;6-(2-Tert-Butylamino-1-hydroxyethyl)-2-hydroxymethylpyridin-3-ol acetate. Grades: 95%. CAS No. 65652-44-0. Molecular formula: C14H24N2O5. Mole weight: 300.35. | |
| Piribedil dihydrochloride | Piribedil dihydrochloride is a dopamine receptor agonist that is selective for the D3 subtype, for which it has 20 times higher affinity than for D2, and possesses no significant affinity for D1 receptors. Synonyms: 2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine dihydrochloride. Grades: ≥99% by HPLC. CAS No. 1451048-94-4. Molecular formula: C16H18N4O2.2HCl. Mole weight: 371.27. | |
| Pirinixic Acid | WY 14643 (Pirinixic Acid) is a potent peroxisome proliferator and activator of PPARα with EC50 of 1.5 μM. Uses: Carcinogens. Synonyms: WY-14643; WY 14643; WY14643; Pirinixic Acid. Grades: >98%. CAS No. 50892-23-4. Molecular formula: C14H14ClN3O2S. Mole weight: 323.8. | |
| Pirinixic acid aminothiazole | Pirinixic acid aminothiazole is a dual inhibitor of 5-lipoxygenase (5-LO) and microsomal prostaglandin E2 synthase 1 (mPGES-1) with IC50 values of 0.4 and 0.2 μM, respectively. It also weakly inhibits COX-1 and -2. Synonyms: 2-[4-Chloro-6-[4-(2-naphthyl)-2-thiazolylamino]-2-pyrimidinylthio]octanoic acid. Grades: ≥98%. CAS No. 1492060-44-2. Molecular formula: C25H25ClN4O2S2. Mole weight: 513.1. | |
| Piriprost potassium salt | Piriprost is a structural analog of prostaglandin I2 (PGI2) and an inhibitor of 5-lipoxygenase (5-LO). Piriprost suppresses the synthesis of leukotrienes. Synonyms: U-60257B; 5-[(4R,5R)-5-hydroxy-4-[(E,3S)-3-hydroxyoct-1-enyl]-1-phenyl-5,6-dihydro-4H-cyclopenta[b]pyrrol-2-yl]pentanoate potassium salt. Grades: ≥98%. CAS No. 88851-62-1. Molecular formula: C26H34NO4·K. Mole weight: 463.7. | |
| Pirlindole mesylate | Pirlindole mesylate is a highly selective reversible inhibitor of monoamine oxidase type A. Synonyms: 2,3,3a,4,5,6-Hexahydro-8-methyl-1H-pyrazino[3,2,1-j,k]carbazole mesylate. Grades: ≥98% (HPLC). CAS No. 207572-66-5. Molecular formula: C15H18N2.CH3SO3H. Mole weight: 322.42. | |
| Pirmenol | Pirmenol, also known as CI-845, a new antiarrhythmic drug, inhibits muscarinic acetylcholine receptor-operated K+ current in the guinea pig heart. However, pirmenol has minimal effect on the PR and QRS intervals, and thus does not appear to be a Class IC drug either. Synonyms: 4-((2R,6S)-2,6-dimethylpiperidin-1-yl)-1-phenyl-1-(pyridin-2-yl)butan-1-ol; Pirmenol. CAS No. 68252-19-7. Molecular formula: C22H30N2O. Mole weight: 338.49. | |
| Piroctone olamine | Piroctone olamine, a pyridine derivate, is an anti-dandruff agent with fungicidal effect used in shampoo formulations. Synonyms: 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one; octopirox; piroctone olamine. CAS No. 68890-66-4. Molecular formula: C16H30N2O3. Mole weight: 298.42. | |
| Pirodavir | R-77975's predecessor, R 61837, a substituted phenyl-pyridazinamine, was effective in inhibiting 80% of 100 serotypes tested (EC80) at concentrations above 32 micrograms/ml, pirodavir inhibits the same percentage of viruses at 0.064 micrograms/ml. Pirodavir is also effective in inhibiting 16 enteroviruses, with an EC80 of 1.3 micrograms/ml. Pirodavir acts at an early stage of the viral replication cycle (up to 40 min after infection) and reduces the yield of selected rhinoviruses 1,000- to 100,000-fold in a single round of replication. Adults with symptoms of < or=2 days' duration were randomly assigned to intranasal sprays of pirodavir (2 mg per treatment) or placebo six times daily for 5 days. In people with laboratory-documented rhinovirus colds (53 in the pirodavir group, 55 in the placebo group), no significant differences in the resolution of respiratory symptoms were apparent between the groups. The median duration of illness was 7 days in each group. Similarly, scores for individual symptoms found no differences in favor of pirodavir during or after treatment. Synonyms: R 77975; R-77975; R77975; R77,975; R 77,975; R-77,975; Pirodavir. Grades:>98%. CAS No. 124436-59-5. Molecular formula: C21H27N3O3. Mole weight: 369.46. | |
| Piromidic acid | Piromidic acid is a quinolone antibiotic to treat gram-negative bacteria infections. Uses: Quinolone antibacterial. Synonyms: 8-ethyl-5-oxo-2-pyrrolidin-1-ylpyrido[2,3-d]pyrimidine-6-carboxylic acid Acid, Piromidic Piromidic Acid. Grades: 95%. CAS No. 19562-30-2. Molecular formula: C14H16N4O3. Mole weight: 288.30. | |
| Pirtobrutinib | Pirtobrutinib is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Synonyms: BTK inhibitor 16; LY 3527727; LOXO-305; (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide. Grades: >98%. CAS No. 2101700-15-4. Molecular formula: C22H21F4N5O3. Mole weight: 479.4. | |
| PIT | PIT selectively and non-competitively blocked P2Y1 receptor signaling without affecting nucleotide binding. PIT had no significant effect on agonist activation of other P2Y receptors, including P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12 receptors. Synonyms: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-oxide 4-methylbenzenesulfonate; 2,2'-Pyridylisatogen tosylate. Grades: ≥99% by HPLC. CAS No. 56583-49-4. Molecular formula: C13H8N2O2.C7H8O3S. Mole weight: 396.42. | |
| Pitofenone hydrochloride | Pitofenone is an antispasmodic agent and an inhibitor of acetylcholinesterase (AChE). It is commonly used in combination with fenpiverinium bromide and metamizole sodium for the treatment of pain and spasms of smooth muscles. Synonyms: Baralginketone; Bulgarketone; methyl 2-[4-(2-piperidin-1-ylethoxy)benzoyl]benzoate hydrochloride. Grades: ≥98%. CAS No. 1248-42-6. Molecular formula: C22H25NO4·HCl. Mole weight: 403.9. | |
| Pitolisant oxalate | Tiprolisant is potent and selective nonimidazole inverse agonist at the histamine H3 receptor. (Ki=0.16 nM). Uses: The histamine h3 receptor. Synonyms: Tiprolisant oxalate; 1-[3-[3- (4-chlorophenyl) propoxy]propyl]piperidine oxalate. Grades: ≥98%. CAS No. 362665-57-4. Molecular formula: C19H28ClNO5. Mole weight: 385.88. | |
| PJ-34 HCL | PJ34 is a potent specific inhibitor of PARPl/2 with IC50 of 110 nM and 86 nM, respectively. Synonyms: PJ-34 HCL; PJ34 HCL; PJ 34 HCL. CAS No. 344458-19-1. Molecular formula: C17H17N3O2. Mole weight: 295.342. | |
| PK 11195 | PK 11195 has high affinity for the peripheral benzodiazepine receptor (PBR, TSPO) without binding to other known neurotransmitter receptors. It can also inhibit the human constitutive androstane receptor (hCAR). In Mar 2006, Preclinical for Cancer in United Kingdom was discontinued. Uses: Anticancer. Synonyms: PK11195; PK-11195; PK 11195. 1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide; N-Methyl-N-(1-methylpropyl)-1-(2-chlorophenyl)isoquinoline-3-carboxamide; RP 52028; RP52028; RP-52028. Grades: 98%. CAS No. 85532-75-8. Molecular formula: C21H21ClN2O. Mole weight: 352.86. | |
| PK 44 phosphate | PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM, which displays >1000-fold selectivity for DPP-IV over DPP-8 and DPP-9. Synonyms: PK-44 phosphate; PK44 phosphate; (3R)-3-Amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-1-butanone phosphate; 1-Butanone, 3-amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-, (3R)-, phosphate (1:1); (R)-3-amino-4-(6,7-difluoro-1H-indazol-3-yl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one phosphate. Grades: ≥98% by HPLC. CAS No. 1017682-66-4. Molecular formula: C17H16F5N7O.H3PO4. Mole weight: 527.34. | |
| PK7242 maleate | PK7242 is an inducer of reactivation of mutant p53 in cancer cells. Synonyms: 2-[4-(4-fluorophenyl)-3-pyrrol-1-ylpyrazol-1-yl]-N,N-dimethylethanamine maleate. Grades: ≥95%. CAS No. 1446352-68-6. Molecular formula: C17H19FN4·C4H4O4. Mole weight: 414.4. | |
| PKC-9 | PKC-9 is a potent and selective inhibitor of PKCζ with IC50 value of 5.18 nM. Synonyms: 4-[3-[7-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl]-benzenamine. Grades: ≥95%. CAS No. 1132609-87-0. Molecular formula: C25H25N7. Mole weight: 423.51. | |
| PKCα (C2-4) Inhibitor Peptide | PKCα (C2-4) inhibitor peptide is an inhibitor of PKC activity in HepG2 cells stimulated with calcium and pancreastatin when applied at 10 μM. Synonyms: Protein Kinase Cα (C2-4) Inhibitor Peptide. Grades: ≥95%. Molecular formula: C47H74N14O17. Mole weight: 1107.2. | |
| PKCε Inhibitor Peptide | PKC? inhibitor peptide is a synthetic peptide that inhibits the translocation of PKC? to intracellular membranes, blocking activation. PKC? inhibitor peptide is commonly used in cells to evaluate the role of PKC? in various cellular responses. Synonyms: Protein Kinase C? Inhibitor Peptide; ?V1-2. Grades: ≥95%. CAS No. 182683-50-7. Molecular formula: C37H65N9O13. Mole weight: 844. | |
| PKC-IN-1 | PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies. Ki: 14.9 nM. Uses: Pkc-in-1 has been found to be a pkcβii inhibitor that probably has biological activity in antineoplastic studies. Synonyms: PKC-IN-1; SCHEMBL3325504; CS-4284; DA-48103; HY-16903; CS 4284; DA 48103; HY 16903; CS4284; DA48103; HY16903. Grades: 98%. CAS No. 1046787-18-1. Molecular formula: C25H37FN8O2. Mole weight: 500.61. | |
| PKCθ Pseudosubstrate Inhibitor | PKCθ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCθ activity. Synonyms: Protein Kinase Cθ Pseudosubstrate Inhibitor. Grades: ≥95%. Molecular formula: C95H165N39O20. Mole weight: 2173.6. | |
| PKC ζ pseudosubstrate | PKC ζ pseudosubstrate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that attached to cell permeabilisation Antennapedia domain vector peptide. Synonyms: Myristolated PKC Zeta, Pseudosubstrate (ZIP); Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH. Molecular formula: C208H336N74O44S3. Mole weight: 4673.59. | |
| PKCζ Pseudosubstrate Inhibitor | PKCζ pseudosubstrate inhibitor is a synthetic peptide that inhibits PKCζ activity. Synonyms: Protein Kinase Cζ Pseudosubstrate Inhibitor. Grades: ≥95%. CAS No. 799764-07-1. Molecular formula: C76H128N30O16. Mole weight: 1718. | |
| PKI-166 | PKI-166 is an ATP-competitive EGFR inhibitor with >3000-fold selectivity against a panel of serine/threonine kinases. It inhibits the growth and metastasis in pancreatic cancer. It also exhibits potential therapeutic effects against several cardiovascular (CV) conditions, including hypertension, heart failure, and cardiac and vascular hypertrophy. Uses: Protein kinase inhibitors. Synonyms: PKI 166; PKI166; CGP-75166; NVP-PKI166; 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol. Grades: ≥98%. CAS No. 187724-61-4. Molecular formula: C20H18N4O. Mole weight: 330.4. | |
| PKI 166 hydrochloride | PKI 166 is a potent EGFR-kinase inhibitor (IC50 = 0.7 nM), with >3000-fold selectivity against a panel of serine/threonine kinases. PKI 166 potently inhibits the growth and metastasis of many human cancers including human pancreatic cancer. Synonyms: PKI 166 hydrochloride; PKI166 hydrochloride; PKI-166 hydrochloride; 4-[4-[[(1R)-1-Phenylethyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl]phenol hydrochloride; PKI 166 HCl. Grades: ≥98% by HPLC. Molecular formula: C20H18N4O.HCl. Mole weight: 366.84. | |
| PKI-179 hydrochloride | PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR), displaying potential antineoplastic activity. Synonyms: N-[4-[4-(4-morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl]phenyl]-N'-4-pyridinyl-urea monohydrochloride. Grades: ≥98%. CAS No. 1463510-35-1. Molecular formula: C25H28N8O3·HCl. Mole weight: 525. | |
| PKI-402 | PKI-402 is a selective, reversible, ATP-competitive, equipotent inhibitor of class I phosphatidylinositol 3-kinases (PI3K), including PI3K-alpha mutants, and mammalian target of rapamycin (mTOR; IC(50) versus PI3K-alpha = 2 nmol/L). PKI-402 inhibited growth of human tumor cell lines derived from breast, brain (glioma), pancreas, and non-small cell lung cancer tissue and suppressed phosphorylation of PI3K and mTOR effector proteins (e.g., Akt at T308) at concentrations that matched those that inhibited cell growth. Synonyms: PKI-402; PKI 402; PKI402. Grades: 0.98. CAS No. 1173204-81-3. Molecular formula: C29H34N10O3. Mole weight: 570.658. | |
| PK-THPP | PK-THPP is a potent antagonist of tandem pore potassium channel subunit TASK-3 (KCNK9, K2P9.1) with an IC50 value of 35 nM for TASK-3 compared to 303 nM for TASK-1 and with >140 fold selectivity over a wider range of potassium channels. PK-THPP ncreases breathing rate and induces respiratory alkalosis in rats. It induced a respiratory alkalosis and increased oxygenation. Synonyms: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone; PK-THPP; PK THPP; PKTHPP. Grades: ≥99% by HPLC. CAS No. 1332454-07-5. Molecular formula: C29H32N4O2. Mole weight: 468.59. | |
| PL 017 | PL 017, a morphiceptin analog, is a selective μ opioid receptor agonist (IC50= 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Although the affinity of PL017 for μ-sites is lower than that of morphine, PL 017 is more potent than morphine in all in vitro studies, suggesting a difference in the way in which peptide and alkaloid activate μ-receptors. Synonyms: Tyr-Pro-MePhe-D-Pro; PL 017; PL017; PL-017. CAS No. 83397-56-2. Molecular formula: C29H37N5O5. Mole weight: 535.64. | |
| Platelet-derived Growth Factor | Platelet-derived Growth Factor (PDGF) is a growth factor that regulates the growth of cells and blood vessels. PDGF consists of five isoforms, including PDGF-AA (PDGFA), -BB (PDGFB), -CC (PDGFC), and -DD (PDGFD), and -AB (a PDGFA and PDGFB heterodimer). Synonyms: PDGF. | |
| Plinabulin | Plinabulin is a vascular disrupting agent (VDA) against tubulin-depolymerizing with IC50 value of 9.8~18 nM in tumor cells under the development of Nereus Pharmaceuticals. It can bind to the colchicine binding site of b-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network. In Sep 2016, BeyondSpring Pharmaceuticals planed a phase II/III trial for Neutropenia. Phase I clinical trials for Solid tumours and Phase III clinical trials for Non-small cell lung cancer are on-going. Uses: Non-small cell lung cancer; neutropenia;solid tumours. Synonyms: NPI 2358; NPI2358; NPI-2358; Plinabulin; UNII-986FY7F8XR; (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione. Grades: 98%. CAS No. 714272-27-2. Molecular formula: C19H20N4O2. Mole weight: 339.39. | |
| PLpro inhibitor | Cas No. 1093070-14-4. | |
| PLS-123 | PLS-123 is a novel covalent irreversible Bruton's Tyrosine Kinase inhibitor. PLS-123 shows potent anti-proliferative effects in multiple cellular and in vivo preclinical models of B-cell lineage malignancy. PLS-123 may become a drug candidate for treatment of B cell cancers. Uses: B cell cancers. Synonyms: PLS-123; PLS 123; PLS123. N- (2- ( (3- (2-acrylamidoacetamido) phenyl) amino) pyrimidin-5-yl) -2-methyl-5- (3- (trifluoromethyl) benzamido) benzamide. Grades: 98%. CAS No. 1431727-04-6. Molecular formula: C31H26F3N7O4. Mole weight: 617.59. | |
| PLX4720 | PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. Synonyms: PLX 4720; PLX-4720. Grades: >98%. CAS No. 918505-84-7. Molecular formula: C17H14ClF2N3O3S. Mole weight: 413.82. | |
| PLX51107 | PLX51107 is a potent and selective BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2). It blocks the interaction mediated by the four BET family proteins. Synonyms: (S)-4-(6-(3,5-dimethylisoxazol-4-yl)-1-(1-(pyridin-2-yl)ethyl)-1H-pyrrolo[3,2-b]pyridin-3-yl)benzoic acid; PLX 51107; PLX-51107. CAS No. 1627929-55-8. Molecular formula: C26H22N4O3. Mole weight: 438.48. | |
| PLX7904 | PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. PB04 is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells. Synonyms: PLX7904; PLX-7904; PLX 7904; PB04; PB-04; PB 04; paradox-breaker-04. Grades: 98%. CAS No. 1393465-84-3. Molecular formula: C24H22F2N6O3S. Mole weight: 512.54. | |
| PMPA (NMDA antagonist) | PMPA (NMDA antagonist) is a selective competitive antagonist at the NMDA receptor, with Ki= 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Synonyms: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid. CAS No. 113919-36-1. Molecular formula: C6H13N2O5P. Mole weight: 224.15. | |
| p-MPPF dihydrochloride | p-MPPF dihydrochloride is a selective 5-HT1A antagonist. Synonyms: p-MPPF dihydrochloride; p MPPF dihydrochloride; pMPPF dihydrochloride. 4-Fluoro-N-(2-[4-(2-methoxyphenyl)1-piperazinyl]ethyl)-N-(2-pyridinyl)benzamide dihydrochloride. Grades: 99%. CAS No. 223699-41-0. Molecular formula: C25H27FN4O2.2HCl. Mole weight: 525.66. | |
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