BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Pronethalol hydrochloride | Pronethalol hydrochloride is a β-adrenergic antagonist. Synonyms: 2-Isopropylamino-1-(2-naphthyl)ethanol hydrochloride. Grades: ≥99% by HPLC. CAS No. 51-02-5. Molecular formula: C15H19NO.HCl. Mole weight: 265.78. |  |
| Prop-2-ynyl-2-aminotetraline hydrochloride | Prop-2-ynyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist. Synonyms: N-prop-2-ynyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; Aminotetraline hydrochloride, Prop-2-ynyl-2-. Grades: 99%. CAS No. 134467-59-7. Molecular formula: C13H15N.HCl. Mole weight: 221.73. | |
| Propantheline Bromide | Propantheline Bromide is an antimuscarinic agent used as an antispasmodic for the treatment of ulcers. Uses: An antimuscarinic agent used in the treatment of hyperhidrosis. Synonyms: Neometantyl; Neopepulsan; methyl-di(propan-2-yl)-[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium;bromide. Grades: ≥97%. CAS No. 50-34-0. Molecular formula: C23H30BrNO3. Mole weight: 448.40. | |
| Propenyl-L-NIO hydrochloride | Propenyl-L-NIO hydrochloride is a potent and selective inhibitor of iNOS. Synonyms: ENIPO. Grades: ≥90%. Molecular formula: C10H19N3O2·HCl. Mole weight: 249.7. | |
| Propiomazine Hydrochloride | Propiomazine hydrochloride is an antihistamine-blocking H1 receptor used to treat insomnia and produce drowsiness. It is also used to relieve anxiety before or during surgery or other procedures. Synonyms: 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-, hydrochloride (1:1); 1-Propanone, 1-[10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-, monohydrochloride; 1-Propanone, 1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]-, monohydrochloride; Largon; 1-(10-(2-(dimethylamino)propyl)-10H-phenothiazin-2-yl)propan-1-one hydrochloride. Grades: 95%. CAS No. 1240-15-9. Molecular formula: C20H25ClN2OS. Mole weight: 376.95. | |
| Prostaglandin A3 | Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay. Synonyms: PGA3; (Z)-7-[(1R)-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid. Grades: ≥98%. CAS No. 36614-31-0. Molecular formula: C20H28O4. Mole weight: 332.4. | |
| Prostaglandin B2 | Prostaglandin B2 (PGB2) is a non-enzymatic dehydration product resulting from the treatment of PGE2 or PGA2 with strong base. Synonyms: PGB2; (Z)-7-[2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopenten-1-yl]hept-5-enoic acid. Grades: ≥98%. CAS No. 13367-85-6. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| Prostaglandin D2 | Prostaglandin D2 (PGD2) is the major eicosanoid product found in mast cells and brain. It has been shown to induce inflammation such as allergic asthma. Synonyms: PGD2; 11-Dehydroprostaglandin F2-alpha; (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 41598-07-6. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| Prostaglandin E2 ethanolamide | Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 with improved water solubility. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA) and acts as an agonist of E prostanoid (EP) receptors 1-4 with Ki values of 2.45, 0.46, 0.2, and 0.51 μM, respectively. Synonyms: Dinoprostone ethanolamide; PGE2-EA; Prostamide E2; N-(11R,15S-dihydroxy-9-oxo-5Z,13E-prostadienoyl)-ethanolamine; (5Z,11α,13E,15S)-11,15-Dihydroxy-N-(2-hydroxyethyl)-9-oxo-prosta-5,13-dien-1-amide; PGE2 ethanolamide; Prostaglandin E2-EA; N-(2-hydroxyethyl)-9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide. Grades: ≥98%. CAS No. 194935-38-1. Molecular formula: C22H37NO5. Mole weight: 395.53. | |
| Prostaglandin F2β | Prostaglandin F2β (PGF2β) is the 9β-hydroxy stereoisomer of PGF2α and acts as a PGF2α activity antagonist. It also can be used as a bronchodilator. Synonyms: PGF2β; PGF2beta; Prostaglandin F2b; PGF2b. Grades: ≥95%. CAS No. 4510-16-1. Molecular formula: C20H34O5. Mole weight: 354.49. | |
| Prostaglandin F3α | PGF3α is a COX metabolite of EPA. It acts as a weak FP receptor antagonist. Synonyms: PGF3α; PGF3alpha; Prostaglandin F3alpha; 9S,11R,15S-trihydroxy-5Z,13E,17Z-prostatrienoic acid; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3S,5Z)-3-hydroxyocta-1,5-dienyl]cyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 745-64-2. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| Prostaglandin H1 | Prostaglandin H1 (PGH1) is a COX metabolite of DGLA and is the precursor to all 1-series PGs and thromboxanes. PGH1 is a suicide inhibitor of platelet thromboxane synthase with Ki value of 28 μM. Synonyms: PGH1; 9S,11R-epidioxy-15S-hydroxy-13E-prostaenoic acid; 9alpha,11alpha-epidioxy-15(S)-hydroxy-13-trans-prostenoic acid. Grades: ≥95%. CAS No. 52589-22-7. Molecular formula: C20H34O5. Mole weight: 354.5. | |
| Prostaglandin I3 sodium salt | PGI3 is a metabolite of EPA by COX and PGI synthase. PGI3 has a short in vivo half-life and is hydrolyzed to Δ17-6-keto PGF1&alpha. Synonyms: PGI3; 6,9alpha-Epoxy-11alpha,15S-dihydroxy-prosta-5Z,13E,17Z-trien1-oic acid sodium salt. Grades: ≥99%. CAS No. 68324-96-9. Molecular formula: C20H29O5·Na. Mole weight: 372.4. | |
| Prostaglandin J2 | Prostaglandin J2 (PGJ2) is a metabolite of PGD2, exhibiting antimitotic and antiproliferative effects. It inhibits platelet aggregation with IC50 value of 5-10 nM. Uses: Antineoplastic agents. Synonyms: PGJ2; 9-Deoxy-delta-9-prostaglandin D2; 9-Deoxy-delta-9-pgd2; (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid. Grades: ≥95%. CAS No. 60203-57-8. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| Prostratin | Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). It is an unusual non-tumorigenic phorbol ester and is found in the bark of the mamala tree of Samoa, Homalanthus nutans (Euphorbiaceae). It has potential to be useful in the treatment of HIV as it could flush viral reservoirs in latently infected CD4+ T-cells. It exhibits promising therapeutic potential against other diseases such as cancer and Alzheimer's disease. It inhibits growth and induces differentiation of AML cell lines. It inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Uses: Prostratin has potential to be useful in the treatment of hiv. it exhibits promising therapeutic potential against other diseases such as cancer and alzheimer's disease. Synonyms: (1aR,1bS,4aR,7aS,7bR,8R,9aS)-9a-(Acetyloxy)-1,1a,1b,4,4a,7a,7b,8,9,9a -decahydro-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl- 5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one;13-O-Acetylphorbol;NSC 623310;(1aR)-1, 1aα, 1bβ, 4, 4a, 7aα, 7b, 8, 9, 9a-Decahydro-4a. Grades: 95%. CAS No. 60857-08-1. Molecular formula: C22H30O6. Mole weight: 390.47. | |
| Prothionamide | An anti-tuberculosis agent. It has also been used to treat Leprosy. Antibacterial (tuberculostatic). Synonyms: Protionamide. Grades: >98%. CAS No. 14222-60-7. Molecular formula: C9H12N2S. Mole weight: 180.27. | |
| Proxalutamide | Proxalutamide is a non-steroidal androgen receptor (AR) antagonist with potential anti-tumor activity for the treatment of prostate cancer and breast cancer. Synonyms: GT 0918; pruxelutamide; Benzonitrile, 4-[4,4-dimethyl-3-[6-[3-(2-oxazolyl)propyl]-3-pyridinyl]-5-oxo-2-thioxo-1-imidazolidinyl]-3-fluoro-2-(trifluoromethyl)-. Grades: 98.79%. CAS No. 1398046-21-3. Molecular formula: C24H19F4N5O2S. Mole weight: 517.5. | |
| Proxyfan maleate | Proxyfan oxalate is a high affinity histamine H3 receptor ligand (pKi = 8.62), acting as a protean agonist with activity ranges from full agonist to inverse agonist depending on system used. Uses: Histamine antagonists. Synonyms: 4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate. Grades: ≥98% by HPLC. CAS No. 177708-09-7. Molecular formula: C17H20N2O5. Mole weight: 332.4. | |
| Proxyfan oxalate | Proxyfan oxalate is a high affinity histamine H3 receptor ligand (pKi = 8.62) that acts as a protean agonist at recombinant and native receptors. Synonyms: 4-[3-(Phenylmethoxy)propyl]-1H-imidazole oxalate. Grades: ≥98% by HPLC. CAS No. 1620017-81-3. Molecular formula: C13H16N2O·C2H2O4. Mole weight: 306.32. | |
| Proxymetacaine hydrochloride | Proparacaine Hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. IC50(ED50): 3.4 mM. Uses: Proparacaine hydrochloride is a topical ophthalmic anesthetic, acting by inhibiting the voltage-gated sodium channels. Synonyms: Proxymetacaine hydrochloride. Grades: 95%. CAS No. 5875-6-9. Molecular formula: C16H26N2O3.HCl. Mole weight: 330.85. | |
| Proxyphylline | Proxyphylline is a metabolite of theophylline in human plasma. It acts as a selective antagonist of A1 adenosine receptors, and exhibits vasodilatory and cardiac stimulatory effects. Uses: Bronchodilator agents. Synonyms: NSC 163343; Proxiphylline; Purophyllin; Monophylline; 7-(2-hydroxypropyl)-1,3-dimethylpurine-2,6-dione. Grades: ≥98%. CAS No. 603-00-9. Molecular formula: C10H14N4O3. Mole weight: 238.2. | |
| PRT-060318 | PRT-060318, also known as PRT318 or P142-76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. Synonyms: PRT-060318; PRT 060318; PRT060318; PRT318; P1426. CAS No. 1194961-19-7. Molecular formula: C18H24N6O. Mole weight: 340.431. | |
| PRT-060318 dihydrochloride | PRT-060318, also known as PRT318 or P142-76, is a novel selective inhibitor of the tyrosine kinase Syk, as an approach to HIT treatment. PRT318 completely inhibited HIT immune complex-induced aggregation of both human and transgenic HIT mouse platelets. Transgenic HIT model mice were treated with KKO, a mouse monoclonal HIT-like antibody, and heparin. The experimental group received orally dosed PRT318, whereas the control group received vehicle. Nadir platelet counts of PRT318-treated mice were significantly higher than those of control mice. When examined with a novel thrombosis visualization technique, mice treated with PRT318 had significantly reduced thrombosis. The Syk inhibitor PRT-060318 thus prevented both HIT immune complex-induced thrombocytopenia and thrombosis in vivo, demonstrating its activity in HIT. Synonyms: PRT-060318 2HCl; PRT318 dihydrochloride; PRT318 2HCl. Molecular formula: C18H24N6O·2HCl. Mole weight: 413.34. | |
| PRX-07034 hydrochloride | PRX-07034 is a potent and selective 5-HT6 receptor antagonist. It was shown to improve cognition and memory in rats. Synonyms: PRX-07034; PRX07034; PRX 07034; PRX-07034 HCl; N-(1-(5-Chloro-2,3-dimethoxyphenyl)ethyl)-2-(methylsulfonyl)-5-(piperazin-1-yl)aniline hydrochloride. Grades: ≥98% by HPLC. CAS No. 903580-39-2. Molecular formula: C21H28ClN3O4S·HCl. Mole weight: 490.44. | |
| PRX 08066 | PRX 08066, a selective 5-hydroxytryptamine receptor 2B(5-HT2BR) antagonist, causes selective vasodilation of pulmonary arteries. Its IC50 value is 3.4 nM. It can potentially inhibit the pathologic 5-HT-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (PAH). It reduces monocrotaline-induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. It shows effects on the vascular muscularization induced by 5-HT in the in vitro studies. It inhibits 5-HT-induced mitogen-activated protein kinase activation and markedly reduces thymidine incorporation in Chinese hamster ovary cells expressing the human 5-HT2BR in vitro. It decrea...ts and mice without affecting the systemic mean arterial pressure in the animals. It is also found to have anti-proliferative and anti-fibrotic effects. It was developed by Allergan company and is in clinical phase 2 with no progression. Uses: Prx 08066 can potentially inhibit the pathologic 5-ht-induced vascular muscularization and is developed to treat for pulmonary arterial hypertension (pah). it is also found to have anti-proliferative and anti-fibrotic effects. Synonyms: PRX-08066; PRX 08066; PRX08066. 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]methyl]-2-fluorobenzonitrile. Grades: >98%. CAS No. 866206-54-4. Molecular formula: C19H17ClFN5S. Mole weight: 401.89. | |
| PRX-08066 maleic acid | PRX-08066 Maleic acid is a selective 5-HT2B receptor antagonist with IC50 value of 3.4 nM. Synonyms: PRX-08066 maleate; 5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-Butenedioate. CAS No. 866206-55-5. Molecular formula: C19H17ClFN5S·C4H4O4. Mole weight: 517.96. | |
| PS 1145 dihydrochloride | PS 1145 is a highly specific small-molecule IKK inhibitor (IC50 = 100 nM). Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo. Effects of PS 1145 on proliferation and apoptosis correlated with inhibition of interleukin (IL)-6, cyclin D1, D2, inhibitor of apoptosis (IAP)-1 and IAP-2 gene expression and decreased IL-6 protein level. Synonyms: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide; PS 1145 dihydrochloride; PS-1145 dihydrochloride; PS1145 dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1049743-58-9. Molecular formula: C17H11ClN4O.2HCl. Mole weight: 395.67. | |
| PSB 0739 | PSB 0739 is a highly potent, direct-acting and reversible P2Y12 receptor antagonist (Ki = 24.9 nM). Unlike clopidogrel, it does not require bioactivation. P2Y12 receptors regulate CFA-induced hyperalgesia and the local inflammatory response, and platelet P2Y12 receptors contribute to these effects in the chronic inflammation phase. Synonyms: 1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt; PSB-0739; PSB 0739; PSB0739 sodium. Grades: ≥95% by HPLC. CAS No. 1052087-90-7. Molecular formula: C26H17N3Na2O8S2. Mole weight: 609.54. | |
| PSB 0777 ammonium salt | PSB 0777 is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors), with subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). The beneficial effects of PSB-0777 on inflammatory parameters were prevented by the pharmacological blockade of A2A receptors. No adverse cardiovascular events were observed upon PSB-0777 administration. The novel A2A receptor agonist PSB-0777 could represent the base for the development of innovative pharmacological entities able to act in an event-specific and site-specific manner. Synonyms: PSB 0777 ammonium salt; PSB0777 ammonium salt; PSB-0777 ammonium salt; 4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt. Grades: ≥98% by HPLC. CAS No. 2122196-16-9. Molecular formula: C18H20N5O7S2.NH4. Mole weight: 500.55. | |
| PSB 10 hydrochloride | PSB 10 is a potent and highly selective antagonist for the human adenosine A3 receptor that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). It produces thermal hyperalgesia in mice in vivo. Synonyms: PSB 10 hydrochloride; PSB10 hydrochloride; PSB-10 hydrochloride; 8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride. Grades: ≥98% by HPLC. CAS No. 591771-91-4. Molecular formula: C16H14Cl3N5O.HCl. Mole weight: 435.14. | |
| PSB 1114 | PSB 1114, a β,γ-difluoromethylene derivative of 4-thio-UTP, is a potent, selective P2Y2 agonist (EC50 = 0.134 μM),with >60-fold selectivity versus P2Y4 and P2Y6 receptors. PSB 1114 activated P2Y2, P2Y4 and P2Y6 with EC50 values of 0.134, 9.3 and 7.0 μM respectively. Synonyms: 4-Thiouridine-5'-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt; PSB1114; PSB 1114; PSB-1114. Grades: ≥98% by HPLC. CAS No. 1657025-60-9. Molecular formula: C10H11F2N2Na4O13P3S. Mole weight: 622.14. | |
| PSB-1115 potassium salt | PSB-1115 is a highly selective antagonist of the adenosine A2B receptor with Ki value of 53.4 nM. Uses: Psb 1115 is an adenosine a2b-r antagonist. Synonyms: potassium;4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonate;trihydrate; potassium;4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonate;trihydrate. Grades: ≥ 98 %. CAS No. 409344-71-4. Molecular formula: C14H13N4O5SK. Mole weight: 388.44. | |
| PSB 11 hydrochloride | PSB 11 hydrochloride, an anti-inflammatory imidazopurinone, has displayed potent and highly selective antagonist characteristics towards human Adenosine A3-R, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). It displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Synonyms: 5H-Imidazo[2,1-i]purin-5-one, 8-ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-, hydrochloride (1:1), (8R)-; PSB11 hydrochloride; PSB-11 hydrochloride; (8R)-8-Ethyl-3,4,7,8-tetrahydro-4-methyl-2-phenyl-5H-imidazo[2,1-i]purin-5-one hydrochloride (1:1); 5H-Imidazo[2,1-i]purin-5-one, 8-ethyl-1,4,7,8-tetrahydro-4-methyl-2-phenyl-, monohydrochloride, (8R)-; (R)-8-ethyl-4-methyl-2-phenyl-7,8-dihydro-3H-imidazo[2,1-i]purin-5(4H)-one Hydrochloride. Grades: ≥98% by HPLC. CAS No. 453591-58-7. Molecular formula: C16H17N5O.HCl. Mole weight: 331.80. | |
| PSB-12062 | PSB-12062 is a potent and selective P2X4 antagonist (IC50 = 1.38 μM for human P2X4) which has potential to be used as a therapeutic target for neutopathic pain, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. Synonyms: 10-(4-methylphenyl)sulfonylphenoxazine; N-(p-methylphenylsulfonyl)phenoxazine; PSB-12062; PSB 12062; PSB12062; 10-tosyl-10H-phenoxazine. CAS No. 55476-47-6. Molecular formula: C19H15NO3S. Mole weight: 337.39. | |
| PSB 36 | PSB 36 is a potent and selective A1 adenosine receptor antagonist with binding affinities of 0.12, 187, 552, 6500 and 2300 nM for rA1, hA2B, rA2A, rA3 and hA3 receptors respectively. Synonyms: PSB 36; PSB36; PSB-36; 1-Butyl-8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-3-(3-hydroxypropyl)-1H-purine-2,6-dione. Grades: ≥99% by HPLC. CAS No. 524944-72-7. Molecular formula: C21H30N4O3. Mole weight: 386.49. | |
| PSB-SB1202 | PSB-SB1202 is a benzylcoumarin compound that acts as an agonist of CB1 and CB2 receptors with EC50 values of 56 and 14 nM, respectively. Synonyms: 5-Methoxy-3-[(2-methoxyphenyl)methyl]-7-pentylchromen-2-one. Grades: ≥98%. CAS No. 1399049-60-5. Molecular formula: C23H26O4. Mole weight: 366.5. | |
| Pseudo RACK1 | Pseudo RACK1 is an activator of protein kinase C which is a family of protein kinase enzymes involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. Molecular formula: C144H225N43O34S3. Mole weight: 3198.81. | |
| PSN 375963 hydrochloride | PSN 375963 is a potent and selective agonist of GPR119 (EC50= 8.4 and 7.9 μM at human and mouse receptors respectively), which shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human GPR119 receptors. PSN375963 may be useful as a therapeutic agent for the treatment of obesity. Synonyms: PSN375963; PSN 375963; PSN-375963; 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine hydrochloride. Grades: ≥98% by HPLC. CAS No. 388575-52-8. Molecular formula: C17H23N3O.HCl. Mole weight: 321.84. | |
| PSN632408 | PSN632408 is an optimized agonist of GPR119 receptors that shows similar potency to OEA at both recombinant mouse and human GPR119 receptors. It suppresses food intake, reduces weight gain, and white adipose tissue deposition in rats. It may be useful as a therapeutic agent for the treatment of obesity. Synonyms: PSN632408; PSN 632408; PSN-632408. Grades: >98%. CAS No. 857652-30-3. Molecular formula: C18H24N4O4. Mole weight: 360.41. | |
| PSNCBAM-1 | PSNCBAM-1 is an allosteric, non-competitive antagonist of CB-1 (IC50= 45 and 209 nM) with hypophagic effects in vivo, potentially an anti-obesity agents. Synonyms: N-(4-Chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]urea; PSNCBAM-1; PSNCBAM 1; PSNCBAM1. Grades: ≥99% by HPLC. CAS No. 877202-74-9. Molecular formula: C22H21ClN4O. Mole weight: 392.88. | |
| Psora 4 | Psora 4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. Synonyms: 4-(4-Phenylbutoxy)-7H-furo[3,2-g][1]benzopyran-7-one. Grades: ≥99% by HPLC. CAS No. 724709-68-6. Molecular formula: C21H18O4. Mole weight: 334.37. | |
| PT 1 | PT 1 is an AMPK (AMP-activated protein kinase) activator that stimulates AMPK heterotrimer (α1β1γ1) activity (EC50=0.3 μM). PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes. It stimulates AMPK heterotrimer (α1β1γ1) activity (EC50 = 0.3 μM). Selectively increases the activity of γ1- but not γ3-containing complexes. Synonyms: PT 1; PT1; PT-1; 2-Chloro-5-[[5-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-4-oxo-2-thiazolyl]amino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 331002-70-1. Molecular formula: C23H16ClN3O6S. Mole weight: 497.91. | |
| PTACH | PTACH is a SAHA-based novel inhibitor of histone deacetylase (HDAC). It exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1.1 to 9.1 μM. It shows strong activity in cancer cell growth inhibition assay. It inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer. It could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction, more effectively than SAHA. It upregulated anti-oxidant molecules including peroxiredoxin 1 and 2 and glutathione S-transferase at the protein level. It exhibits cytotoxicity by sustaining ROS at the higher level greater than SAHA. Uses: Ptach exerts potent growth inhibition against various human cancer cells. it could inhibit the cell growth of a variety of lymphoid malignant cells through apoptosis induction. Synonyms: NCH-51; NCH 51; NCH51. PTACH;Cpd 51;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)heptyl) 2-methylpropanethioate;S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;2-Methylpropanethioicacid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester. Grades: >98%. CAS No. 848354-66-5. Molecular formula: C20H26N2O2S2. Mole weight: 390.56. | |
| PTAC oxalate | PTAC oxalate is a muscarinic receptor ligand, which shows partial agonist activity at the M2 and M4 receptors, with minor antagonistic activity at m1, m3, m5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Synonyms: (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate. Grades: ≥98% by HPLC. CAS No. 201939-40-4. Molecular formula: C12H19N3S2.C2H2O4. Mole weight: 359.46. | |
| PTIQ | PTIQ inhibits the expression of MMP-3 (IC50 = 60 nM) and suppresses proinflammatory responses in mouse model with Parkinson's disease. It also suppresses proinflammatory responses and inhibits NO production in activated microglia. Synonyms: 1-(3,4-Dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolinyl)-1-propanone. Grades: ≥98% by HPLC. CAS No. 1032822-42-6. Molecular formula: C13H17NO3. Mole weight: 235.28. | |
| PT-S58 | PT-S58 is a full peroxisome proliferator-activated receptor (PPAR) β/δ antagonist as a derivative of GSK0660. But PT-S58 has a three-fold higher affinity for the receptor than GSK0660. PT-S58 can inhibit agonist-induced target gene expression. Unlike GSK0660, PT-S58 can block the recruitment co-repressor molecules such as SMRT. Synonyms: PT-S58; PT-S-58; PT-S 58. methyl 3-(N-(4-(tert-butylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate. Grades: 98%. CAS No. 1356497-92-1. Molecular formula: C17H22N2O5S2. Mole weight: 398.49. | |
| PU 02 | PU 02 is a potent and selective 5-HT3 receptor antagonist (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively). It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. Synonyms: PU-02; PU 02; PU02. 6-[(1-Naphthalenylmethyl)thio]-9H-purine. Grades: ≥97% by HPLC. CAS No. 313984-77-9. Molecular formula: C16H12N4S. Mole weight: 292.36. | |
| Purvalanol A | Purvalanol A is a potent CDK inhibitor, which effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. indicating that the activation of CDKs contributes to the c-Src transformation. Purvalanol A suppressed the c-Src activity as effectively as the Src-selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced a strong G2-M arrest, whereas PP2 weakly acted on the G1-S transition. Furthermore, when compared with PP2, purvalanol A more effectively suppressed the growth of human colon cancer HT29 and SW480 cells, in which Src family kinases and CDKs are activated. These findings demonstrate that the coordinated inhibition of cell cycle progression and tyrosine kinase signaling by the multi-selective purvalanol A is effective in suppressing cancer progression associated with c-Src up-regulation. Synonyms: Purvalanol A, Purv; NG60; NG-60; NG 60. Grades: 0.98. CAS No. 212844-53-6. Molecular formula: C19H25ClN6O. Mole weight: 388.89. | |
| Purvalanol B | Purvalanol B is a potent, selective, reversible and ATP-competitive inhibitor of CDK with IC50 values of 6, 6, 9, > 10,000, and 6 nM for cdc2/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK4/cyclin D1 and CDK5-p35, respectively. Synonyms: NG 95; NG95; NG-95. Grades: >98%. CAS No. 212844-54-7. Molecular formula: C20H25ClN6O3. Mole weight: 432.91. | |
| PWZ-029 | PWZ-029, a benzodiazepine derivative, has been found to be a GABAA receptors inverse agonist that could probably improve memory and exhibit sedative effects at some extent at higher doses. Synonyms: PWZ-029; PWZ 029; PWZ029; SCHEMBL6847260; BDBM50034820; 3-Methoxymethyl-5-methyl-8-chloro-4,5-dihydro-6H-imidazo[1,5-a][1,4]benzodiazepin-6-one; 8-Chloro-3-methoxymethyl-5-methyl-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one. Grades: 98%. CAS No. 164025-33-6. Molecular formula: C14H14ClN3O2. Mole weight: 291.74. | |
| PX 102 | PX102 is a Farnesoid X-activated Receptor (FXR) agonist originated by Phenex Pharmaceuticals. PX102 demonstrated potent plasma cholesterol-lowering activity that affected all lipoprotein species. But treatment for Metabolic syndrome and Non-alcoholic steatohepatitis were discontinued. Uses: Metabolic syndrome; non-alcoholic steatohepatitis. Synonyms: PX 102; PX102; PX-102; UNII-378SU5NO8S; 378SU5NO8S; SCHEMBL17087854; Px-102; PX20606; 4- [ (1S, 2S) -2- [2-chloro-4- [ [5-cyclopropyl-3- (2, 6-dichlorophenyl) -1, 2-oxazol-4-yl] methoxy] phenyl] cyclopropyl] benzoic acid. Grades: 98%. CAS No. 1268245-19-7. Molecular formula: C29H22Cl3NO4. Mole weight: 554.85. | |
| PX-13-17OH | PX-13-17OH is a PI3K inhibitor with selectivity for PI3Kα, PI3Kβ, PI3K?, and PI3Kδ (IC50s = 6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50 = 2.9 μM). It inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 μg/ml. Synonyms: WAY-266176; (1E, 4S, 4aR, 5R, 6aS, 7S, 9aR) -5- (acetyloxy) -1-[[[3- (dimethylamino) propyl]methylamino]methylene]-4a, 5, 6, 6a, 7, 8, 9, 9a-octahydro-cyclopenta[5, 6]naphtho[1, 2-c]pyran-2, 10 (1H, 4H) -dione. Grades: ≥98%. CAS No. 884539-95-1. Molecular formula: C29H42N2O8. Mole weight: 546.7. | |
| PX 20350 | PX 20350 is a farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FXR direct reporter (DR) assay (6 nM vs 30 nM for GW 4064). It exhibits a linear dose-dependent reduction in total plasma triglycerides and total plasma cholesterol. Synonyms: PX 20350; PX20350; PX-20350; PX 20350 - FXR agonist Cpd 22; 4-[[[6-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]-2-(trifluoromethyl)pyridin-3-yl]-methylamino]methyl]benzoic acid. Grades: 99%. CAS No. 1198085-23-2. Molecular formula: C28H22Cl2F3N3O4. Mole weight: 592.39. | |
| PX20606 (Trans racemate) | Cas No. 1268244-85-4. | |
| PX-866-17OH | PX-866-17OH is an active metabolite of PX-866 that acts as an inhibitor of PI3K with selectivity for PI3Kα, PI3Kβ, PI3K?, and PI3Kδ (IC50s = 14, 57, 131, and 148 nM, respectively). Synonyms: [(1S,3aR,6E,9S,9aR,10R,11aS)-6-[[bis(prop-2-enyl)amino]methylidene]-1,5-dihydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-10-yl] acetate. Grades: ≥98%. CAS No. 1012327-63-7. Molecular formula: C29H37NO8. Mole weight: 527.6. | |
| Pyr10 | Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-ROCE and SOCE respectively. Uses: Pyr10 is a trpc3-selective inhibitor that could be effective in the study of cellular functions. Synonyms: Pyr10; Pyr-10; Pyr 10; N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methyl-benzenesulfonamide. Grades: 98%. CAS No. 1315323-00-2. Molecular formula: C18H13F6N3O2S. Mole weight: 449.37. | |
| Pyr3 | Pyr3, a pyrazole derivative, is a selective antagonist of the TRP canonical 3 channel (TRPC3) which can function as a receptor-operated channel. It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM. Synonyms: Pyr3; Pyr-3; Pyr 3; 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1160514-60-2. Molecular formula: C16H11Cl3F3N3O3. Mole weight: 456.63. | |
| Pyr6 | Pyr6, a pyrazole derivative, is a selective inhibitor of ransient receptor potential cation 3 (TRPC3) channels that inhibited Orai1- and TRPC3-mediated Ca(2+) entry. IC50= 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells). Synonyms: N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamidePyr6; Pyr-6; Pyr 6C17H9F7N4OCHEMBL101896SCHEMBL732572 9N- (4- (3, 5-Bis (tri fluoro methyl ) -1H-pyrazol-1-yl ) phenyl ) -3-fluoro isonicotinamide N- [4- [3, 5-Bis (tri fluoro methyl ) -1H-pyrazole-1-yl ] ph. CAS No. 245747-08-4. Molecular formula: C17H9F7N4O. Mole weight: 418.27. | |
| Pyrantel pamoate | Pyrantel pamoate is used as a deworming agent in domesticated animals such as horses, hamsters, sheep, pigs, cats, and dogs. It is a combination of pyrantel and pamoic acid. It is used to study mechanisms underlying gut dysfunction in a murine model. It has been used as an anthelmintic treatment of children in Bangladesh and has been studied for it's effect on host physiology, growth, and biochemical status. Synonyms: Pyrantel embonate; Antiminth; Cobantril. Grades: >98%. CAS No. 22204-24-6. Molecular formula: C34H30N2O6S. Mole weight: 594.68. | |
| Pyrantel tartrate | Pyrantel is used to study neuronal nicotinic receptors and has been is used to treat parasiticinfections in livestock. Pyrantel tartrate salt is used to study allosteric modulation of the neuronal nicotinic acetylcholine receptors (nAChRs). Synonyms: Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]-, (2R,3R)-2,3-dihydroxybutanedioate (1:1); Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]-, (E)-, [R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1); Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-[2-(2-thienyl)vinyl]-, (E)-, tartrate (1:1); 1,4,5,6-Tetrahydro-1-methyl-2-[trans-2-(2-thienyl)vinyl]pyrimidine tartrate (1:1); Banminth; CP 10423-18; Pyrequan tartrate; Strongid; Strongid C; trans-1-Methyl-1,4,5,6-tetrahydro-2-[2-(thienyl)vinyl]pyrimidine tartrate; Pyrantel (+)-tartrate salt. Grades: >98%. CAS No. 33401-94-4. Molecular formula: C15H20N2O6S. Mole weight: 356.39. | |
| Pyridoclax | Pyridoclax, a pyridine derivative, has been found to be a Mcl-1 inhibitor that could induce apoptosis of cancer cells. IC50: 25 nM(Kd). Synonyms: Pyridoclax; MR29072; MR 29072; MR29072; SCHEMBL17060301; CS-3777; KB-333747; B4901; 2-(5-methyl-6-pyridin-3-ylpyridin-3-yl)-3-[(E)-2-phenylethenyl]-5-pyridin-3-ylpyridine. Grades: 98%. CAS No. 1651890-44-6. Molecular formula: C29H22N4. Mole weight: 426.52. | |
| Pyridostigmine bromide | Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor used to treat myasthenia gravis and reverse the effects of muscle relaxants. Synonyms: Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide (1:1); Kalimin; Kalymin; Mestinon; Mestinon Bromide; NSC 679759; Piridostigmin; 3-Hydroxy-1-methylpyridinium bromide, dimethylcarbamate; Carbamic acid, dimethyl-, ester with 3-hydroxy-1-methylpyridinium bromide; Pyridinium, 3-[[(dimethylamino)carbonyl]oxy]-1-methyl-, bromide; Pyridinium, 3-hydroxy-1-methyl-, bromide, dimethylcarbamate; 1-Methyl-3-hydroxypyridinium bromide dimethylcarbamate; 3-(Dimethylcarbamoyloxy)-1-methylpyridinium bromide; 3-(Dimethylcarbamyloxy)-1-methylpyridinium bromide; 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide; Regonol; Ro 1-5130. Grades: >98%. CAS No. 101-26-8. Molecular formula: C9H13BrN2O2. Mole weight: 261.12. | |
| Pyridoxatin | Pyridoxatin is a MMP-2 (Gelatinase A) inhibitor and antibiotic isolated from Acremonium. It was shown to inhibit DNA synthesis in PC-3 prostate cancer cells. It is effective against cancer invasion and metastasis. Synonyms: Tolypocin; Pyridoxatine; (-)-Pyridoxatin; 3-[(1S,2R,4S,6R)-2-ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxypyridin-2-one. Grades: ≥98%. CAS No. 135529-30-5. Molecular formula: C15H21NO3. Mole weight: 263.33. | |
| Pyrilamine maleate salt | Pyrilamine maleate salt is a first generation antihistamine and binds with high affinity to G(q/11) protein. It is commonly utilized as a radioligand binding assay for the H1 receptor. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms. It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan. It is also found to be a potent inhibitor of CYP2D6 in hepatocytes. It has been listed. Uses: Pyrilamine maleate salt is commonly utilized as a radioligand binding assay for the h1 receptor. it also has anticholinergic properties. it is used in over-the-counter combination products to treat the common cold and menstrual symptoms. Synonyms: N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine fumarate;Diaminide maleate;(Z)-but-2-enedioic acid;N-[(4-Methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl- 1,2-ethanediamine (2Z)-2-Butenedioate;Paraminyl Maleate. Grades: 95%. CAS No. 59-33-6. Molecular formula: C21H27N3O5. Mole weight: 401.46. | |
| Pyrithioxin | Pyrithioxin, a pyridine thiol derivatives, could be used in the treatment of traumatic brain injury sequelae and some sorts of cerebral infarct patients with Hemiplegia. Uses: Pyrithioxin could be used in the treatment of traumatic brain injury sequelae and some sorts of cerebral infarct patients with hemiplegia. Synonyms: PYRITHIOXIN; PYRITHIOXINE; PYRITINOL; 3, 3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethano; 3, 3'-(dithiobis(methylene))bis(5-hydroxy-6-methyl-4-pyridinemethanol); 3, 3'-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethano; biocefalin; bonol. Grades: 98%. CAS No. 1098-97-1. Molecular formula: C16H20N2O4S2. Mole weight: 368.47. | |
| Pyrithioxin dihydrochloride | Pyrithioxin dihydrochloride, a pyridine thiol derivative, is a nootropic which could be used in the treatment of sequelae of brain trauma, encephalitis and meningitis as well as the prevention of some cerebrovascular diseases. Uses: Pyrithioxin dihydrochloride is a nootropic which could be used in the treatment of sequelae of brain trauma, encephalitis and meningitis as well as the prevention of some cerebrovascular diseases. Synonyms: Pyrithioxine hydrochloride; Pyrithioxine HCl; Life; NSC 526973; NSC-526973; NSC526973; Pyriditol; Bonifen; Dinerfene; PYRITHIOXIN DIHYDROCHLORIDE;PYRITINOL DIHYDROCHLORIDE;PYRITINOL HYDROCHLORIDE;3,3'-(dithiodimethylene)bis(5-hydroxy-6-methyl-4-pyridinemethanodihydrochl;3,3'-dithiobis(methylene)bis(5-hydroxy-6-methyl-4-pyridinemethanol)dihydroch;3,3'-dithiodimethylenebi. Grades: 95%. CAS No. 10049-83-9. Molecular formula: C16H20N2O4S2.2HCl. Mole weight: 441.38. | |
| Pyrrolidinedithiocarbamate Ammonium | Pyrrolidinedithiocarbamate ammonium is a selective NF-κB inhibitor, inducing apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells. Uses: Induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia hl-60 cells. Synonyms: 1-Pyrrolidinecarbodithioic Acid, Ammonium Salt; Ammonium 1-Pyrrolidinecarbodithioat. Grades: ≥98%. CAS No. 5108-96-3. Molecular formula: C5H9NS2.NH3. Mole weight: 164.29. | |
| Pyrrophenone | Pyrrophenone is an inhibitor of cytosolic phospholipase A2α (cPLA2α) with an IC50 of 4.2 nM in enzyme assays. It potently inhibited arachidonic acid release in calcium ionophore (A23187)-stimulated human monocytic cells (THP-1 cells) in a dose-dependent manner with IC50 value of 0.024 mM. Synonyms: N-[[(2S,4R)-1-[2-(2,4-Difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide. Grades: ≥95%. CAS No. 341973-06-6. Molecular formula: C49H37F2N3O5S2. Mole weight: 850. | |
| Pz-1 | Pz-1 is a cell-permeable, non-cytotoxic (up to 0.1 μM and 6 days; NIH/3T3 cells), and highly potent RET and VEGFR2 inhibitor with IC50s of less than 1 nM for both wild type kinases. Synonyms: N-(5-(Tert-Butyl)isoxazol-3-yl)-2-(4-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)phenyl)acetamide. CAS No. 1800505-64-9. Molecular formula: C26H26N6O2. Mole weight: 454.52. | |
| PZ-II-029 | PZ-II-029,a pyrazoloquinolinone, was reported as the first postitive modulator of GABAA α6β3γ2 subtype functionally selective ligands to date. Synonyms: 3H-Pyrazolo[4,3-c]quinolin-3-one, 2,5-dihydro-7-methoxy-2-(4-methoxyphenyl)-; 2,5-Dihydro-7-methoxy-2-(4-methoxyphenyl)-3H-pyrazolo[4,3-c]quinolin-3-one; PZII-029; PZ II-029; PZ-II029; PZII029; PZ II029; PZII 029. Grades: ≥98% by HPLC. CAS No. 164025-44-9. Molecular formula: C18H15N3O3. Mole weight: 321.33. | |
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