BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Ravuconazole | Ravuconazole, also known as BMS-207147 or ER-30346, is a potent, broad spectrum and broad spectrum triazoleantifungle agent and an ergosterol biosynthesis inhibitor. Synonyms: Ravuconazole; BMS-207147; ER-30346 ; BMS207147; ER30346 ; ER30346. 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile; BMS 207147; ER 30346. CAS No. 182760-06-1. Molecular formula: C22H17F2N5OS. Mole weight: 437.47. |  |
| Razupenem | Razupenem is an injectable, 1β-methylcarbapenem antibacterial performed well against a variety of bacterial strains. Uses: Antibacterial. Synonyms: SMP-601; SMP601; SMP 601; PTZ601; PTZ-601; PTZ 601; PZ-601; SM-216601; SM 216601; SM216601; Razupenem.(4R,5S,6S)-3-[[4-[(5S)-2,5-Dihydro-5-methyl-1H-pyrrol-3-yl]-2-thiazolyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid. Grades: ≥95%. CAS No. 426253-04-5. Molecular formula: C18H21N3O4S2. Mole weight: 407.51. | |
| RB394 | RB394 is an orally bioavailable, dual modulator of soluble epoxide hydrolase (sEH) and PPARγ that inhibits sEH with an IC50 of 0.33 μM and activates PPARγ with an EC50 of 0.3 μM. Synonyms: RB-394; RB 394; 2- [ [4- [ [4-Methoxy-2- (trifluoromethyl) phenyl] methylcarbamoyl] phenyl] methyl] butanoic acid. Grades: ≥98%. CAS No. 1830320-32-5. Molecular formula: C21H22F3NO4. Mole weight: 409.4. | |
| R-BC154 | R-BC154, a high affinity fluorescent α4β1/α9β1 integrin antagonist (Kd= 12.7 and 38 nM, respectively), was based on a series of N-phenylsulfonyl proline dipeptides and assembled using the Cu(I)-catalyzed azide alkyne cycloaddition (CuAAC) reaction. R-BC154 represents a useful multi-purpose fluorescent integrin probe that can be used for screening small molecule inhibitors of α9β1 and α4β1 integrins; investigating the biochemical properties of α9β1 and α4β1 integrin binding and investigating integrin expression and activation on defined cell phenotypes in vivo. Synonyms: R-BC154; R BC154; RBC154; (4R)-4-[4-[[[[4-[3,6-Bis(diethylamino)xanthylium-9-yl]-3-sulfophenyl]sulfonyl]amino]methyl]-1H-1,2,3-triazol-1-yl]-1-(phenylsulfonyl)-L-prolyl-O-(1-pyrrolidinyl)-L-tyrosine acetate. Grades: ≥97% by HPLC. Molecular formula: C55H61N9O13S3.CH3CO2H. Mole weight: 1212.37. | |
| RBI 257 maleate | RBI 257 is a potent dopamine D4 receptor antagonist with Ki value of 0.3 nM. Synonyms: (Z)-But-2-enedioic acid; N-[1-[(4-iodophenyl)methyl]piperidin-4-yl]-N-methyl-3-propan-2-yloxypyridin-2-amine. Grades: ≥95%. CAS No. 911378-38-6. Molecular formula: C21H28IN3O·C4H4O4. Mole weight: 581.4. | |
| RBN-2397 | RBN-2397 is a competitive inhibitor of NAD+ PARP7. It has the potential to study advanced or metastatic solid tumors. Synonyms: Atamparib. Grades: ≥98% by HPLC. CAS No. 2381037-82-5. Molecular formula: C20H23F6N7O3. Mole weight: 523.4. | |
| (R)-BPO-27 | (R)-BPO-27, the benzopyrimido-pyrrolo-oxazinedione, is a potent CFTR inhibitor (IC50 = 4 nM) with low-nanomolar potency. Synonyms: (R)-BPO 27; (R)-BPO27. CAS No. 1415390-47-4. Molecular formula: C26H18BrN3O6. Mole weight: 548.34. | |
| (R)-Butaprost | Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Butaprost has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1 methyl ester; TR 4978; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid methyl ester. Grades: ≥98%. CAS No. 69648-38-0. Molecular formula: C24H40O5. Mole weight: 408.6. | |
| (R)-Butaprost (free acid) | Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype. Synonyms: (±)-15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 15-deoxy-16R-hydroxy-17-cyclobutyl PGE1; 9-oxo-11α,16R-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid. Grades: ≥98%. CAS No. 215168-33-5. Molecular formula: C23H38O5. Mole weight: 394.6. | |
| (R)-CPP | (R)-CPP, a piperazine derivative, has been found to be an effective NMDA receptor antagonist. Synonyms: 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid. Grades: ≥95% by HPLC. CAS No. 126453-07-4. Molecular formula: C8H17N2O5P. Mole weight: 252.21. | |
| (R)-CR8 | Molecular glue; brings about ubiquination and degradation of cyclin K. Synonyms: (R)-CR8; (R)-CR-8; (R)-CR 8; CR8; CR-8; CR 8; CR8 CDK inhibitor; CR8 CDK inhibitor HCl; CR8 CDK inhibitor hydrochloride; (R)-CR8 trihydrochloride. Grades: ≥99% (HPLC). CAS No. 1786438-30-9. Molecular formula: C24H29N7O.3HCl. Mole weight: 540.92. | |
| RD 162 | RD 162 is an orally bioactive and second-generation antagonist of androgen receptor (AR). It inhibits 18F-FDHT binding to AR in human prostate cancer cells thus is used for the treatment of advanced prostate cancer. Uses: Advanced prostate cancer therapy. Synonyms: RD 162; RD162; RD-162; 4-[7-[4-cyano-3-(trifluoromethyl)phenyl]-8-oxo-6-sulfanylidene-5,7-diazaspiro[3.4]octan-5-yl]-2-fluoro-N-methylbenzamide. Grades: 98%. CAS No. 915087-27-3. Molecular formula: C22H16F4N4O2S. Mole weight: 476.45. | |
| RD3-0028 | RD3-0028 is a potent and selective inhibitor of RSV replication with EC50 value of 4.5 μM. Synonyms: 1,4-dihydro-2,3-benzodithiine; 1,4-dihydro-2,3-benzodithiin. Grades: ≥98% (HPLC). CAS No. 3886-39-3. Molecular formula: C8H8S2. Mole weight: 168.28. | |
| (R)-DPN | (R)-DPN has been found to be an estrogen receptor (ER) β agonist with higher affinity for estrogen receptor. Synonyms: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile. Grades: ≥98% by HPLC. CAS No. 524047-78-7. Molecular formula: C15H13NO2. Mole weight: 239.27. | |
| (R)-DRF053 dihydrochloride | The hydrochloride salt form of (R)-DRF053, which is a cdk/CK1 inhibitor and could be used in studies in the cancer treatment with combinations of CDK kinase and ERK inhibitors. Synonyms: (R)-DRF053 dihydrochloride; (R)-DRF 053 dihydrochloride; (R)-DRF-053 dihydrochloride; 2-[[9-(1-Methylethyl)-6-[[3-(2-pyridinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1241675-76-2. Molecular formula: C23H27N7O.2HCl. Mole weight: 490.43. | |
| Rec 15/2615 dihydrochloride | Rec 15/2615 dihydrochloride is a selective α1B-adrenoceptor antagonist (Ki = 0.3, 1.9 and 2.6 nM at human α1B, α1A and α1D receptors, respectively) potentially for the treatment of female sexual dysfunction. Synonyms: Ethanone, 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]-, hydrochloride (1:2); 1-[4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]-2-[2-methoxy-6-(1-methylethyl)phenoxy]ethanone hydrochloride (1:2); Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[2-methoxy-6-(1-methylethyl)phenoxy]acetyl]-, dihydrochloride; Rec-15/2615 dihydrochloride; Rec15/2615 dihydrochloride. Grades: ≥95%. CAS No. 1782573-48-1. Molecular formula: C26H33N5O5.2HCl. Mole weight: 568.49. | |
| Recoflavone | Recoflavone, also referred to DA 6034, is a synthetic flavonoid derivative known to possess anti-inflammatory activity in phase ? clinical trials for the treatment of inflammatory bowel disease. With gastroprotective and ulcer healing activity, Recoflavone promotes gastric epithelial cell migration and wound-healing through the mTOR pathway, and induced mucin secretion via Ca2+-dependent pathways through P2Y receptor stimulation. Synonyms: DA-6034; DA 6034; DA6034; Recoflavone; 2-[2-(3,4-dimethoxyphenyl)-5-methoxy-4-oxochromen-7-yl]oxyacetic acid; 7-carboxymethoxyloxy-3',4',5-trimethoxyflavone;recoflavone. Grades: >98%. CAS No. 203191-10-0. Molecular formula: C20H18O8. Mole weight: 386.356. | |
| Refametinib | Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor RDEA119 specifically inhibits mitogen-activated protein kinase kinase 1 (MAP2K1 or MAPK/ERK kinase 1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK, a dual specificity threonine/tyrosine kinase, is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: RDEA119; RDEA-119; RDEA 119; BAY 869766; BAY-69766; BAY869766; BAY 86 9766; BAY 86-9766; BAY86-9766; BAY 869766. Grades: >98%. CAS No. 923032-37-5. Molecular formula: C19H20F3IN2O5S. Mole weight: 572.338. | |
| Refametinib R enantiomer | Refametinib R enantiomer is a potent, selective and allosteric inhibitor of MEK1/2 in enzyme inhibition assays. It has been reported to inhibit MEK activity and inhibit anchorage-dependent growth. Moreover, it has shown a potent tumor growth inhibition (TGI) in the human A375 and colon carcinoma Colo205 tumor xenograft models. Synonyms: BAY 869766 R enantiomer; RDEA119 R enantiomer; BAY869766 R enantiomer; RDEA 119 R enantiomer; BAY-869766 R enantiomer; RDEA-119 R enantiomer. Grades: >98%. CAS No. 923032-38-6. Molecular formula: C19H20F3IN2O5S. Mole weight: 572.34. | |
| Regrelor | Regrelor is a P2Y12 antagonist. In Dec 2008, Phase-II for Thrombosis in USA was discontinued. Uses: Thrombosis. Synonyms: UNII-Q6C8TY6SW1; CHEMBL1162175; 787548-03-2; Regrelor [INN]; INS50589;[(2S,3aR,4R,6R,6aR)-4-[6-(ethylcarbamoylamino)purin-9-yl]-2-[(E)-2-phenylethenyl]-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methyl dihydrogen phosphate. Grades: 98%. CAS No. 787548-03-2. Molecular formula: C22H25N6O8P. Mole weight: 532.45. | |
| Rehmannioside A | Rehmannioside A is an iridoid glucoside extracted from the roots of Rehmannia glutinosa. Synonyms: [(1aS, 1bα, 5aα, 6aβ)-1a, 1b, 2, 5a, 6, 6a-Hexahydro-6α-hydroxy-1aβ-(hydroxymethyl)oxireno[4, 5]cyclopenta[1, 2-c]pyran-2α-yl]6-O-α-D-galactopyranosyl-β-D-glucopyranoside;(2S, 3R, 4S, 5R, 6R)-2-[[(2R, 3S, 4S, 5R, 6S)-6-[[(1aS, 1bS, 2S, 5aR, 6S, 6aS)-6-hydroxy-1a-(hydroxymethyl)-2, 5a, 6, 6a-tetrahydro-1bH-oxireno[5, 6]cyclopenta[1, 3-c]pyran-2-yl]oxy]-3, 4, 5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3, 4, 5-triol. Grades: >98%. CAS No. 81720-05-0. Molecular formula: C21H32O15. Mole weight: 524.47. | |
| Rehmannioside D | Rehmannioside D is a carotenoid glycoside extracted from the roots of Rehmannia glutinosa. Synonyms: [(1S,7aα)-1α-(β-D-Glucopyranosyloxy)-5,7a-dihydro-5α-hydroxy-7-(hydroxymethyl)cyclopenta[c]pyran-4aα(1H)-yl]2-O-β-D-glucopyranosyl-β-D-glucopyranoside;(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5S,6R)-2-[[(1S,4aS,5R,7aR)-5-hydroxy-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-5,7a-dihydro-1H-cyclopenta[c]pyran-4a-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol. Grades: >98%. CAS No. 81720-08-3. Molecular formula: C27H42O20. Mole weight: 686.61. | |
| Remacemide hydrochloride | Remacemide, also known as PR-934423 and FPL 12924AA, is a non-competitive NMDA receptor antagonist, which blocks ion channel and allosteric modulatory site (IC50 = 8-68 mM). Remacemide Hydrochloride has been used in pharmaceutical studies as a potential treatment to ischemic stroke, epilepsy, Parkinson's disease and Huntington's disease. Synonyms: 2-Amino-N-(1-methyl-1,2-diphenylethyl)acetamide hydrochloride; PR-934423; PR934423 PR 934423; PR 934-423A; FPL 12924AA; Remacemide hydrochloride. Grades: ≥99% by HPLC. CAS No. 111686-79-4. Molecular formula: C17H20N2O.HCl. Mole weight: 304.82. | |
| Remodelin | Remodelin, a 2-thiazolylhydrazone derivative, is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10, which acetylates both histones and microtubules. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. It is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging. It also has cytotoxic effects against some species of the fungus Candida. Synonyms: Remodelin; 949912-58-7; CHEMBL399572; 4-[2-(2-cyclopentylidenehydrazinyl)-1,3-thiazol-4-yl]benzonitrile4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile. Grades: >98%. CAS No. 949912-58-7. Molecular formula: C15H14N4S. Mole weight: 282.36. | |
| Remogliflozin | Remogliflozin is a selective inhibitor of sodium-glucose transporter 2 (SGLT2) that promotes blood glucose to be eliminated through the urine. The prodrug Remoglifozin etabonate (GSK 189075) is converted into remogliflozin in vivo, and is suggested for the treatment of type II diabetes. Uses: The treatment of type ii diabetes. Synonyms: Remogliflozin A; Remogliflozin - GSK189074; GSK-189074; GSK 189074. (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxane-3,4,5-triol. Grades: 99%. CAS No. 329045-45-6. Molecular formula: C23H34N2O7. Mole weight: 450.53. | |
| REMOXIPRIDE HYDROCHLORIDE | Remoxipride is a selective dopamine D2 receptor antagonist. It shows selectivity over D3 and D4 receptors with Ki values are ~ 300nM for D2 receptor, ~ 1600nM for D3 receptor and ~ 2800 nM for D4 receptor. Remoxipride shows antipsychotic activity in vivo with no extrapyramidal side effects. In Jul 1995, treatment for Psychotic disorders in USA was discontinued. Uses: Psychotic disorders. Synonyms: Remoxipride Hydrochloride; Remoxipride HCl; Roxiam; A 33547 hydrochloride; UNII-QS4S72U30K; QS4S72U30K; Remoxipride Hydrochloride Anhydrous ; Remoxipride Monohydrochloride; Remoxipride Monohydrochloride Monohydrate; Remoxipride Monohydrochloride;3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dimethoxybenzamide;hydrochloride. Grades: 98%. CAS No. 73220-03-8. Molecular formula: C16H24BrClN2O3. Mole weight: 407.73. | |
| (R)-Encorafenib | Encorafenib is a Proto oncogene protein b raf inhibitor with potential antineoplastic activity. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of Encorafenib may result in a decrease in proliferation of tumor cells. Now, treatment for Colorectal cancer and Malignant melanoma is in clinical trials Phase III. Treatment for Multiple myeloma and Solid tumours is in clinical trials Phase II. Uses: Colorectal cancer; malignant melanoma;multiple myeloma; solid tumours. Synonyms: LGX818; LGX 818; LGX-818; UNII-8L7891MRB6; methyl N-[(2S)-1-[[4-[3-[5-chloro-2-fluoro-3-(methanesulfonamido)phenyl]-1-propan-2-ylpyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate;1269440-29-0 (R-isomer of LGX-818). Grades: 98%. CAS No. 1269440-29-0. Molecular formula: C22H27ClFN7O4S. Mole weight: 540.01. | |
| Reparixin | Reparixin is an inhibitor of CXCL8 receptor, and also inhibits CXCR1 and CXCR2 activation. Synonyms: (R) -2- (4-isobutylphenyl) propionylmethanesulfonamide; 2- (4-isobutylphenyl) propionylmethanesulfonamide; repertaxin. Grades: 98%. CAS No. 266359-83-5. Molecular formula: C14H21NO3S. Mole weight: 283.39. | |
| Reparixin L-lysine salt | The efficacy of RPX (tested in a wide range of concentrations (1-1000 nM)) was lower in cells expressing Ile43Val CXCR1 mutant (IC50 values of 0.0056 and 0.08 uM for CXCR1 weight and CXCR1 Ile43Val, respectively). Treatment with reparixin significantly counteracts secondary degeneration by reducing oligodendrocyte apoptosis, migration to the injury site of neutrophils and ED-1-positive cells. The best beneficial outcome of reparixin treatment required 7-day administration either by i.p. route (15 mg/kg) or subcutaneous infusion via osmotic pumps (10 mg/kg), reaching a steady blood level of 8 microg/ml. Reparixin effectively decreased systolic blood pressure and increased the blood flow. The thoracic aorta wall thickness was significantly decreased in SHR-R compared to SHR-N. Pre-treatment with reparixin reduced the motor deficits observed in this model of ischemia and reperfusion. Myeloperoxidase activity and IL-iβ were reduced in the reparixin-treated group. Histological analysis revealed that ischemic injury was also attenuated by reparixin pre-treatment. Synonyms: Repertaxin L-lysine salt. Grades: >98%. CAS No. 266359-93-7. Molecular formula: C20H35N3O5S. Mole weight: 429.57. | |
| (R)-Equol | Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora. Synonyms: (+)-Equol; Isoequol; (3R)-3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-ol. Grades: ≥98%. CAS No. 221054-79-1. Molecular formula: C15H14O3. Mole weight: 242.3. | |
| Reserpine hydrochloride | Reserpine hydrochloride is the hydrochloride salt of Reserpine. Reserpine, an indole alkaloid, was used to high blood pressure by irreversibly blocking the vesicular monoamine transporter (VMAT), but it has numerous side-effects. Synonyms: methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride Reserpine hydrochloride Reserpine (hydrochloride) 16994-56-2 Reserpine HCl UNII-GWN3C4FTI8 GW. CAS No. 16994-56-2. Molecular formula: C33H41ClN2O9. Mole weight: 645.14. | |
| reslizumab | Reslizumab is a humanized monoclonal antibody resistant to interleukin-5 (IL-5). It is approved for additional maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype. Uses: The treatment of severe asthma. Synonyms: Cinqair. CAS No. 241473-69-8. | |
| Resminostat | Resminostat is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity. Resminostat binds to and inhibits HDACs leading to an accumulation of highly acetylated histones. This may result in an induction of chromatin remodeling, inhibition of the transcription of tumor suppressor genes, inhibition of tumor cell division and the induction of tumor cell apoptosis. HDACs, upregulated in many tumor types, are a class of enzymes that deacetylate chromatin histone proteins. Synonyms: 4SC201; 4SC-201; 4SC 201; RAS-2410; RAS2410; RAS 2410; Resminostat. CAS No. 864814-88-0. Molecular formula: C16H19N3O4S. Mole weight: 349.405. | |
| Resminostat hydrochloride | Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6. As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study. Synonyms: RAS2410 hydrochloride; 4SC-201 hydrochloride; 4SC 201 hydrochloride; 4SC201 hydrochloride; RAS 2410 hydrochloride; RAS-2410 hydrochloride. Grades: >98%. CAS No. 1187075-34-8. Molecular formula: C16H20ClN3O4S. Mole weight: 385.87. | |
| Resorcinolnaphthalein | Resorcinolnaphthalein is an angiotensin-converting enzyme 2 (ACE2) activator that exerts cardioprotective and renoprotective properties. ACE2 is involved in AMPK/mTOR signaling pathway. Synonyms: NSC 354317. Grades: ≥98%. CAS No. 41307-63-5. Molecular formula: C24H14O5. Mole weight: 382.4. | |
| Retaspimycin | Retaspimycin (IPI 504) is a small-molecule inhibitor of heat shock protein 90 (Hsp90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of Hsp90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of Hsp90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis. Synonyms: IPI-504; IPI 504; IPI504. Grades: >98%. CAS No. 857402-23-4. Molecular formula: C31H45N3O8. Mole weight: 587.70. | |
| Retaspimycin Hydrochloride | Retaspimycin HCl is the hydrochloride salt of a small-molecule inhibitor of Hsp90 with antineoplastic and antiproliferative activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of Hsp90, which maintains the stability and functional shape of many oncogenic signaling proteins and has the possibililty to be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of Hsp90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may lead to the induction of apoptosis. Synonyms: retaspimycin hydrochloride; Retaspimycin HCl; IPI-504; 857402-63-2; IPI-504 HYDROCHLORIDE; CHEBI:71956; IPI 504; Retaspimycin hydrochloride [USAN]; Retaspimycin (Hydrochloride); 928Q33Q049; 857402-63-2 (HCl); [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6,20,22-trihydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16-oxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(22),8,12,14,18,20-hexaen-10-yl] carbamate; hydrochloride; Retaspimycin hydrochloride (USAN); 17-Allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride. Grades: >95%. CAS No. 857402-63-2. Molecular formula: C31H48ClN3O8. Mole weight: 626.17. | |
| Retrobradykinin | Retrobradykinin, a bradykinin analog nonapeptide, shows no significant kinin activity. Synonyms: RFPSFGPPR. CAS No. 5991-13-9. Molecular formula: C50H73N15O11. Mole weight: 1060.22. | |
| REV 5901 | REV 5901 is an antagonist of CysLT1 receptor with Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with IC50 value of 0.12 μM. Uses: Platelet aggregation inhibitors. Synonyms: REV-5901; REV5901; 1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol. Grades: ≥98%. CAS No. 101910-24-1. Molecular formula: C22H25NO2. Mole weight: 335.4. | |
| Reversine | Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Synonyms: Reversine; 656820-32-5; 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine; CHEMBL188343; CHEBI:70723; C21H27N7O; N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine; N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine; Z499CLJ023; MFCD07784513; N~6~-Cyclohexyl-N~2~-(4-Morpholin-4-Ylphenyl)-9h-Purine-2,6-Diamine; N(6)-cyclohexyl-N(2)-[4-(morpholin-4-yl)phenyl]-9H-purine-2,6-diamine; 2vgo. CAS No. 656820-32-5. Molecular formula: C21H27N7O. Mole weight: 393.49. | |
| Revexepride | Revexepride, also referred as SSP-002358, is a very selective and potent 5-HT4 receptor agonist and a novel prokinetic that stimulates gastrointestinal motility, and could be a good candidate drug for the gastroparesis treatment. Synonyms: 4-amino-5-chloro-N-[[(3S,4S)-3-hydroxy-1-(3-methoxypropyl)piperidin-4-yl]methyl]-2,2-dimethyl-3H-1-benzofuran-7-carboxamide; revexepride; SSP-002358; SSP 002358; SSP002358; Revexepride. Grades: >98%. CAS No. 219984-49-3. Molecular formula: C21H32ClN3O4. Mole weight: 425.95. | |
| Rezatomidine | Rezatomidine is a selective α2-adrenoreceptor antagonist under the development of Allergan. No recent development was reported for the treatment of Diabetic neuropathies and Fibromyalgia. Synonyms: 2H-Imidazole-2-thione, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1,3-dihydro-; (S)-4-(1-(2,3-dimethylphenyl)ethyl)-1,3-dihydro-2H-imidazole-2-thione; 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1,3-dihydro-2H-imidazole-2-thione; (+)-(S)-4-[1-(2,3-Dimethylphenyl)ethyl]-1,3-dihydroimidazole-2-thione. Grades: 98%. CAS No. 847829-38-3. Molecular formula: C13H16N2S. Mole weight: 232.35. | |
| (R)-(-)-Flindokalner | (R)-(-)-BMS 204352 is the less active R-(-)-enantiomer of BMS-204352, which is a positive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in HEK293 cells used as an anxiolytic agant. Uses: Anxiolytic agent. Synonyms: (R)-(-)-BMS 204352; (R)-(-)-BMS204352; (R)-(-)-BMS-204352; (3R)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)-1H-indol-2-one. Grades: 98%. CAS No. 187523-36-0. Molecular formula: C16H10ClF4NO2. Mole weight: 359.7. | |
| RG13022 | RG13022, a non-phenolic tyrphostin analog, is an epidermal growth factor (EGF) receptor tyrosine kinase inhibitor with potential antiproliferative effect. Synonyms: RG13022; RG 13022; RG-13022; 3-(3,4-dimethoxyphenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 13022; RG-13022. CAS No. 136831-48-6. Molecular formula: C16H14N2O2. Mole weight: 266.29. | |
| RG14620 | RG14620 is a non-phenolic tyrphostin-class epidermal growth factor receptor (EGFR) inhibitor (IC50= 3 μM for HER 14 colony formation, and IC50= 1 pM for HER 14 DNA synthesis), with anti-proliferative effects on renal and bladder carcinoma cell lines. Synonyms: (E)-3-(3,5-dichlorophenyl)-2-pyridin-3-ylprop-2-enenitrile; RG 14620; RG14620; RG-14620; TYRPHOSTIN RG 14620. CAS No. 136831-49-7. Molecular formula: C14H8Cl2N2. Mole weight: 275.13. | |
| RG2833 | RGFP 109 is a histone deacetylase (HDAC) inhibitor that has shown to reverse FXN gene silencing in short-term studies of Friedreich ataxia (FRDA) patient cells. Synonyms: RG-2833; RG 2833; RG2833; RGFP-109; RGFP 109; RGFP109.; N-[6-(2-Aminophenylamino)-6-oxohexyl]-4-methylbenzamide. Grades: >98%. CAS No. 1215493-56-3. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| RG7090 | RG7090 is a negative modulator of metabotropic glutamate receptor subtype 5 (mGluR5; GRM5). Synonyms: Basimglurant; CTEP Derivative; RG7090; RG 7090; RG-7090. Grades: >98%. CAS No. 802906-73-6. Molecular formula: C18H13ClFN3. Mole weight: 325.77. | |
| RG7129 | Cas No. 1628077-06-4. | |
| RG7834 | RG7834 is a highly selective and orally bioavailable HBV inhibitor, suppressing HBV antigens (both HBsAg and HBeAg) and virion production. Synonyms: RO 7020322; (6S)-6-Isopropyl-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6,7-dihydro-2h-pyrido[2,1-a]isoquinoline-3-carboxylic acid. Grades: ≥98% (HPLC). CAS No. 2072057-17-9. Molecular formula: C22H27NO6. Mole weight: 401.45. | |
| RGB-286638 | RGB-286638 is a novel CDK inhibitor. It inhibited several tyrosine and serine/threonine non-CDK enzymes, i.e. GSK-3β, TAK1, AMPK, Jak2, MEK1. It demonstrated equimolar (50nM) activity in freshly isolated tumor cells from MM patients, while manifesting less cytotoxicity in healthy donor PBMCs. It reduced the phosphorylation of Rb at S807/811 in MM.1S and MM.1R cells, but had no effects on p-Rb S780. Synonyms: RGB-286638; RGB286638; RGB286638. Grades: >98%. CAS No. 784210-87-3. Molecular formula: C29H37Cl2N7O4. Mole weight: 618.55. | |
| RGFP966 | RGFP966 is a selective HDAC3 inhibitor. Systemic treatment with RGFP966 facilitates extinction in mice in a manner resistant to reinstatement. A single treatment of RGFP966 enhances extinction of a previously established cocaine-conditioned place preference, while simultaneously enhancing long-term object-location memory within subjects. During extinction consolidation, HDAC3 inhibition promotes a distinct pattern of histone acetylation linked to gene expression within the infralimbic cortex, hippocampus, and nucleus accumbens. Thus, the facilitated extinction of drug-seeking cannot be explained by adverse effects on performance. These results demonstrate that HDAC3 inhibition enhances the memory processes involved in extinction of drug-seeking behavior. Synonyms: RGFP966; RGFP 966; RGFP-966. Grades: 0.98. CAS No. 1357389-11-7. Molecular formula: C21H19FN4O. Mole weight: 362.4. | |
| RGW2938 | A phosphodiesterase inhibitor. Synonyms: RGW2938; RGW 2938; RGW-2938; 2(1H)?-Quinazolinone, 3,?4-dihydro-3-methyl-6-(1,?4,?5,?6-tetrahydro-6-oxo-3-pyridazinyl)?-. CAS No. 111786-07-3. Molecular formula: C13H14N4O2. Mole weight: 258.28. | |
| RGX-104 hydrochloride | RGX-104 is an orally bioavailable liver X receptor agonist displaying immunomodulating and antineoplastic activity. Synonyms: RGX-104; 2-[3-[ (3R) -3-[[2-Chloro-3- (trifluoromethyl) phenyl]methyl- (2, 2-diphenylethyl) amino]butoxy]phenyl]acetic acid hydrochloride. CAS No. 610318-03-1. Molecular formula: C34H34Cl2F3NO3. Mole weight: 632.54. | |
| (R)-Gyramide A hydrochloride | (R)-Gyramide A is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 μM. Synonyms: (R)-534F6; 5-fluoro-2-methyl-N-[(3R)-1-[[4-(1-methylethoxy)phenyl]methyl]-3-pyrrolidinyl]-benzenesulfonamide monohydrochloride. Grades: ≥95%. CAS No. 1793050-70-0. Molecular formula: C21H27FN2O3S·HCl. Mole weight: 443. | |
| (R)-(+)-HA-966 | (R)-(+)-HA-966 is a cell-permeable antagonist/partial agonist at the glycine site of the NMDA receptor. Synonyms: (R)-(+)-3-Amino-1-hydroxypyrrolidin-2-one. Grades: ≥98% by HPLC. CAS No. 123931-04-4. Molecular formula: C4H8N2O2. Mole weight: 116.12. | |
| R(+)-IAA-94 | R(+)-IAA-94 is a potent indanyloxyacetic acid blocker as an indanyloxyacetic acid (IAA) inhibitor of chloride channels ( Ki =1 μM.). Uses: Inhibitor of chloride channel. Synonyms: Indanyloxyacetic acid; 2-[[(2S)-6,7-dichloro-2-cyclopentyl-2-methyl-1-oxo-3H-inden-5-yl]oxy]acetic acid; (R)-[(6,7-Dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]acetic Acid. Grades: ≥95%. CAS No. 54197-31-8. Molecular formula: C17H18Cl2O4. Mole weight: 357.23. | |
| Ribocil | Ribocil, a newly developed riboswitches chemical modulator, could selectively restrain the expression of GFP and probably influence bacterial cell growth. IC50: 0.3 μM (EC50). Uses: Ribocil is a newly developed riboswitches chemical modulator and could selectively restrain the expression of gfp and probably influence bacterial cell growth. Synonyms: Ribocil; CS-5272; CS 5272; CS5272. Grades: 98%. CAS No. 1381289-58-2. Molecular formula: C19H22N6OS. Mole weight: 382.48. | |
| Ribocil-C | Ribocil-C is a more active analog of ribocil. Ribocil is a potent and highly selective synthetic mimic of FMN and inhibit bacterial growth both in vitro and in vivo. Synonyms: 2-[(3S)-1-[(1-pyrimidin-2-ylimidazol-4-yl)methyl]piperidin-3-yl]-6-thiophen-2-yl-1H-pyrimidin-4-one Ribocil-C. CAS No. 1825355-56-3. Molecular formula: C21H21N7OS. Mole weight: 419.50. | |
| Ribuvaptan | Ribuvaptan is a vasopressin receptor antagonist originated by Bayer HealthCare Pharmaceuticals. Now, Ribuvaptan is still in phase I development for the treatment of Heart failure in Germany. Uses: Heart failure. Synonyms: UNII-6004MB8Y0D; 6004MB8Y0D;[(2R)-2-[[2-[3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1,2,4-triazol-1-yl]acetyl]amino]-2-[3-(trifluoromethyl)phenyl]ethyl] carbamate. Grades: 98%. CAS No. 1245620-47-6. Molecular formula: C23H20ClF6N5O5. Mole weight: 595.88. | |
| Ricinelaidic acid | Ricinelaidic acid is an unsaturated fatty acid that acts as a leukotriene B4 (LTB4) receptor antagonist (Ki = 2 μM in porcine neutrophil membranes). Synonyms: 9-Octadecenoic acid, 12-hydroxy-, (9E,12R)-; 12-D-Hydroxy-9-trans-octadecenoic acid; (E,12R)-12-hydroxyoctadec-9-enoic acid; (9E,12R)-12-Hydroxy-9-octadecenoic acid; 9-Octadecenoic acid, 12-hydroxy-, [R-(E)]-. Grades: ≥98%. CAS No. 540-12-5. Molecular formula: C18H34O3. Mole weight: 298.46. | |
| Ridaifen-B | Ridaifen-B is a novel tamoxifen analog that induces apoptosis. It acts as an antagonist of estrogen receptor α (ERα) with IC50 value of 52.4 nM, and an inverse agonist of cannabinoid receptor 2 (CB2) with Ki value of 43.7 nM. Synonyms: 1-[2-[4-[2-phenyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]but-1-enyl]phenoxy]ethyl]pyrrolidine. Grades: ≥98%. CAS No. 886465-70-9. Molecular formula: C34H42N2O2. Mole weight: 510.7. | |
| RIG-1 modulator 1 | RIG-1 modulator 1 is an inhibitor of HBV, HCV and HIV. Synonyms: CS-8144; HY-107902; 1-[2-(dimethylamino)ethyl]-3-(7-methyl-[1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)urea. Grades: 99.04%. CAS No. 1428729-63-8. Molecular formula: C14H17N5OS2. Mole weight: 335.45. | |
| Rigosertib | Rigosertib, a synthetic benzyl styryl sulfone, is a non-ATP-competitive inhibitor of PLK1 (IC50=9 nM). Uses: A non-atp-competitive inhibitor of plk1. Synonyms: UNII-67DOW7F9GL; 2- [2-methoxy-5- [ [ (E) -2- (2, 4, 6-trimethoxyphenyl) ethenyl] sulfonylmethyl] anilino] acetic acid;ON-01910; ON 01910; ON01910. Grades: ≥95%. CAS No. 592542-59-1. Molecular formula: C21H25NO8S. Mole weight: 451.49. | |
| Rilmenidine hemifumarate | Rilmenidine hemifumarate, a centrally acting antihypertensive agent, is an I1-imidazoline binding site selective ligand and α2-adrenoceptor agonist. Rilmenidine targets the nonadrenergic imidazoline-binding site I1 receptor with a Ki value of 7.1 nM and demonstrates weaker affinity for the I2 receptor with a Ki value of 5.2 μM. Synonyms: 2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate; Oxaminozoline; S 3341. Grades: ≥99% by HPLC. CAS No. 207572-68-7. Molecular formula: C10H16N2O.1/2C4H4O4. Mole weight: 238.29. | |
| Rilzabrutinib | Rilzabrutinib is a Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 1.3 nM. Synonyms: PRN1008. Grades: >98%. CAS No. 1575596-29-0. Molecular formula: C36H40FN9O3. Mole weight: 665.8. | |
| Rimantadine | Rimantadine, an adamantane derivative, could be an effective antiviral drug and probably prevent influenza virus at some extent. Uses: Rimantadine could be an effective antiviral drug and probably prevent influenza virus at some extent. Synonyms: 1-(1-Adamantyl)ethanamine;1-Adamantanemethylamine, alpha-methyl-; alpha-Methyl-1-adamantanemethylamine; alpha-Methyladamantanemethylamine; Tricyclo(3.3.1.13, 7)decane-1-methanamine, alpha-methyl-;Tricyclo[3,3,1,1(3,7)]decane-1-methanamine, alpha-m. Grades: 95%. CAS No. 13392-28-4. Molecular formula: C12H21N. Mole weight: 179.30. | |
| Rimantadine hydrochloride | Rimantadine hydrochloride, also called as Flumadine, is a nucleic acid synthesis inhibitor and an anti-influenza virus drug. Uses: Used as an antiviral agent. Synonyms: 1-(1-adamantyl)ethanamine;hydrochloride. Grades: > 98.0 % (N). CAS No. 1501-84-4. Molecular formula: C12H21N · HCl. Mole weight: 215.76. | |
| Rimcazole dihydrochloride | Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Uses: Anticonvulsants. Synonyms: 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride; cis-9-[3-(3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole Dihydrochloride; rel-9-[3-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]propyl]-9H-carbazole Dihydrochloride (9CI); BW 234U; Rimcazole Hydrochloride. Grades: ≥98% by HPLC. CAS No. 75859-03-9. Molecular formula: C21H27N3.2HCl. Mole weight: 394.39. | |
| Risperidone hydrochloride | Risperidone is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist. Uses: Dopamine d2 receptor antagonists; serotonin 2a receptor antagonists. Synonyms: R 64 766 hydrochloride; R64 766 hydrochloride; R64766 hydrochloride;3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one hydrochloride. Grades: ≥98%. CAS No. 666179-74-4. Molecular formula: C23H28ClFN4O2. Mole weight: 446.94. | |
| Risperidone mesylate | Risperidone is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist. Uses: Dopamine d2 receptor antagonists; serotonin 2a receptor antagonists. Synonyms: R 64 766 mesylate; R64 766 mesylate; R64766 mesylate;3-{2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)-1-piperidinyl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one methanesulfonate. Grades: ≥98%. CAS No. 666179-96-0. Molecular formula: C24H31FN4O5S. Mole weight: 506.59. | |
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