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| Product | Description | |
|---|---|---|
| Q94 hydrochloride | Q94 is a PAR1 negative allosteric modulator that suppresses PAR1-Gαq interaction. Synonyms: 1-[(4-Chlorophenyl)methyl]-2-(phenylmethyl)-1H-benzimidazole hydrochloride; 2-benzyl-1-(4-chlorobenzyl)-1H-benzo[d]imidazole hydrochloride. Grades: ≥99% by HPLC. CAS No. 1052076-77-3. Molecular formula: C21H17ClN2·HCl. Mole weight: 369.29. |  |
| QAQ dichloride | QAQ, a photoisomerizable molecule, is a photoswitchable Nav, Cav and Kv channel blocker, blocking channels in the trans form. It switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. QAQ enables reversible optical silencing of mouse nociceptive neuron firing without exogenous gene expression and can serve as a light-sensitive analgesic in rats in vivo. Moreover, because intracellular QAQ accumulation is a consequence of nociceptive ion channel activity, QAQ-mediated photosensitization provides a new platform for understanding signaling mechanisms in acute and chronic pain. Synonyms: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride. Grades: ≥98% by HPLC. Molecular formula: C28H44Cl2N6O2. Mole weight: 567.59. | |
| QF0301B | QF0301B is an α1 adrenergic receptor antagonist and shows noncompetitive low action in 5-HT3, muscarinic and nicotinic receptors, or as Ca2+ antagonist. Synonyms: 3,4-Dihydro-2-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-1(2H)-naphthalenone. CAS No. 149247-12-1. Molecular formula: C23H28N2O2. Mole weight: 364.48. | |
| QL47 | QL47 is a potent and selective BTK inhibitor, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an IC50 of 7 nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475 nM and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC50 of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest which is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations. Synonyms: QL47; QL 47; QL47. QL-XII-47. Grades: 0.98. CAS No. 1469988-75-7. Molecular formula: C27H21N5O2. Mole weight: 447.48794. | |
| QL-IX-55 | The functional target of QL-IX-55 is the ATP-binding site of TOR2 as evidenced by the discovery of resistant alleles of TOR2 through rational design and unbiased selection strategies. QL-IX-55 is capable of potently inhibiting both TOR complex 1 and 2 (TORC1 and TORC2) as demonstrated by biochem. IP kinase assays (IC50 <50 nM) and cellular assays for inhibition of substrate YPK1 phosphorylation. In contrast to rapamycin, QL-IX-55 is capable of inhibiting TORC2-dependent transcription, which suggests that this compd. will be a powerful probe to dissect the Tor2/TORC2-related signaling pathway in yeast. Synonyms: QL-IX-55. Grades:>98%. CAS No. 1223002-54-7. Molecular formula: C24H14F4N4O. Mole weight: 450.39. | |
| QNZ | QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively. Synonyms: CAY10470; CAY-10470; CAY 10470; QNZ; EVP4593; EVP 4593; EVP-4593. Grades: >98%. CAS No. 545380-34-5. Molecular formula: C22H20N4O. Mole weight: 356.42. | |
| QNZ46 | QNZ46, a NMDA receptor antagonist, has been studied to have potential effect in some neurological diseases for it works by influencing some amino acids combinated to corresponding receptors abnormally. IC50: 3 μM (for NR2D), 6 μM (for NR2C) and 229 μM (fo. Uses: Qnz46 is a nmda receptor antagonist that has been studied to have potential effect in some neurological diseases for it works by influencing some amino acids combinated to corresponding receptors abnormally. Synonyms: QNZ46; QNZ-46; QNZ 46; 1237744-13-6; CHEMBL1215292; C24H17N3O6; (E)-4-(6-Methoxy-2-(3-nitrostyryl)-4-oxoquinazolin-3(4H)-yl)benzoic acid. Grades: 98%. CAS No. 1237744-13-6. Molecular formula: C24H17N3O6. Mole weight: 443.41. | |
| QO 58 | QO 58 is a Kv7 channel opener (EC50= 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). QO-58 showed antinociceptive effects for OA pain in the MIA model after pain development. QO-58 may be an alternative therapeutic treatment for OA. Synonyms: QO-58; QO 58;QO58. 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one. Grades: ≥98% by HPLC. CAS No. 1259536-62-3. Molecular formula: C18H8Cl2F4N4O. Mole weight: 443.18. | |
| QS-1189 | QS-1189 is a reversible, high selective, orally available cyclin-dependent kinase 7 (CDK7) inhibitor developed for cancer therapy. QS-1189 exhibits antitumor activity via modulation of transcription and cell cycle. Uses: Antitumor agent. Synonyms: QS-1189; QS 1189; QS1189. | |
| Quetiapine sulfoxide dihydrochloride | Quetiapine sulfoxide dihydrochloride, a metabolite of Quetiapine, has antipsychotic effect. Synonyms: 2-[2-[4-(11-oxobenzo[b][1,4]benzothiazepin-6-yl)piperazin-1-yl]ethoxy]ethanol;dihydrochloride 329218-11-3 Quetiapine sulfoxide (dihydrochloride) Ethanol, 2-[2-[4-(5-oxidodibenzo[b,f][1,4]thiazepin-11-yl)-1-piperazinyl]ethoxy]- ,dihydrochloride. CAS No. 329218-11-3. Molecular formula: C21H27Cl2N3O3S. Mole weight: 473.44. | |
| Quinagolide hydrochloride | Quinagolide hydrochloride is a selective dopamine D2 receptor agonist, also is a prolactin inhibitor. Synonyms: NORPROLAC, BRN 6074559; BRN6074559; BRN-6074559; CV205-502. Grades: >98%. CAS No. 94424-50-7. Molecular formula: C20H34ClN3O3S. Mole weight: 432.02. | |
| Quinelorane hydrochloride | Quinelorane hydrochloride, 2-aminopyridine analog of quinpirole, is a dopamine D2 and D3 receptor agonist (Ki= 5.7 and 3.4 nM respectively). Synonyms: (5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propyl-pyrido[2,3-g]quinazolin-2-amine Dihydrochloride; (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propyl-pyrido[2,3-g]quinazolin-2-amine Dihydrochloride; LY 163502; LY163502; LY-163502. Grades: ≥99% by HPLC. CAS No. 97548-97-5. Molecular formula: C14H22N4.2HCl. Mole weight: 319.27. | |
| Quinestriol | Cas No. 152-43-2. | |
| (-)-Quinpirole hydrochloride | (-)-Quinpirole hydrochloride is a selective dopamine D2 receptor agonist, with high affinity for the D2 and D3 dopamine receptor subtypes (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively). Synonyms: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride; (-)-Quinpirole hydrochloride; (-)Quinpirole hydrochloride; (-)-Quinpirole HCl; (-)Quinpirole HCl; (-) Quinpirole HCl; LY-171555; LY 171555; LY171555. Grades: ≥98% by HPLC. CAS No. 85798-08-9. Molecular formula: C13H21N3.HCl. Mole weight: 255.79. | |
| Quipazine dimaleate | Quipazine dimaleate is a slective 5-HT3 receptor agonist, and also displays antagonist activity at peripheral 5-HT3 receptors. Quipazine was shown to increase serotonin and decrease 5-hydroxyindoleacetic acid concentrations in whole brain, several brain regions, and the spinal cord of rats 1 hr after its administration (10 mg/kg, i.p.). Synonyms: 2-(1-Piperazinyl)quinoline dimaleate. Grades: ≥99% by HPLC. CAS No. 150323-78-7. Molecular formula: C13H15N3.2C4H4O4. Mole weight: 445.43. | |
| Quisinostat | Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. Synonyms: JNJ-26481585; JNJ26481585; JNJ 26481585. Grades: >98%. CAS No. 875320-29-9. Molecular formula: C21H26N6O2. Mole weight: 394.479. | |
| QX 222 | QX 222, a quaternary ammonium derivative of lidocaine, is a sodium channel blocker. Synonyms: QX 222; QX222; QX-222; 2-[(2,6-Dimethylphenyl)amino]-N,N,N-trimethyl-2-oxoethaniminium Chloride; Trimethyl[(2,6-xylylcarbamoyl)methyl]ammonium Chloride (8CI); 2-[(2,6-dimethylphenyl)amino]-N,N,N-trimethyl-2-oxo-ethanaminium Chloride (9CI); Trimethyl[(2,6-xylylcarbamoyl)methyl]ammonium Chloride (7CI); 2-Dimethylamino-2',6'-dimethylacetanilide Methochloride; QX 222 Chloride. CAS No. 5369-00-6. Molecular formula: C13H21ClN2O. Mole weight: 256.77. | |
| QX 314 bromide | QX 314, a membrane impermeable quaternary derivative of lidocaine, selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. Synonyms: QX-314 Br; QX-314Br; QX314 Br; QX 314; QX314. 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide; Triethyl[(2,6-xylylcarbamoyl)methyl]-ammonium Bromide; 2-[(2,6-Dimethylphenyl)amino]-N,N,N-triethyl-2-oxo-ethanaminium Bromide; N- (2, 6-Dimethylphenylcarbamoylmethyl) triethylammonium Bromide. Grades: ≥99% by HPLC. CAS No. 24003-58-5. Molecular formula: C16H27N2OBr. Mole weight: 343.31. | |
| R112 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. | |
| R-121919 | R-121919 is a potent orally active small-molecule Corticotropin-Releasing factor 1 (CRF1) receptor antagonist for the treatment of anxiety and depression, while having little affinity at the CRF2 receptor subtype. Synonyms: R121919; R-121919; R 121919; R121,919; R-121,919; R 121,919; NBI30775; NBI 30775; NBI-30775;3-(6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL)-2,5-DIMETHYL-N,N-DIPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-AMINE; 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine. Grades: >98%. CAS No. 195055-03-9. Molecular formula: C22H32N6. Mole weight: 380.53. | |
| R 121919 hydrochloride | R 121919 hydrochloride is a potent and orally available corticotropin releasing factor receptor1 (CRF1) antagonist. Synonyms: 3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 195055-66-4. Molecular formula: C22H32N6·HCl. Mole weight: 416.99. | |
| R 1485 dihydrochloride | R 1485 dihydrochloride is a selective and high affinity 5-HT6 antagonist (pKi = 8.9), with >100 fold selectivity against a panel of 50 targets including other 5-HT receptor subtypes. Synonyms: R 1485 dihydrochloride; R1485 dihydrochloride; R-1485 dihydrochloride; 4-[(2-Fluorophenyl)sulfonyl]-3,4-dihydro-8-(1-piperazinyl)-2H-1,4-benzoxazine dihydrochloride; R 1485.2HCl. Grades: ≥98% by HPLC. Molecular formula: C18H20FN3O3S.2HCl. Mole weight: 450.35. | |
| R1530 | R1530 is a pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. R1530 is also a mitosis-angiogenesis inhibitor (MAI) that inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis. Synonyms: R-1530; R 1530. Grades: >98%. CAS No. 882531-87-5. Molecular formula: C18H14ClFN4O. Mole weight: 356.78136. | |
| R-1 methanandamide | R-1 methanandamide is a potent cannabinoid (CB) receptor 1 agonist with selectivity for CB1 over CB2 receptors with Ki values ranging from 17.9 to 28.3 and 815 to 868 nM, respectively. Synonyms: (R)-methanandamide; R(+)-Methanandamide; R-(+)-methanandamide; AM-356; AM 356; AM356; (R)-(+)-Arachidonyl-1'-Hydroxy-2'-Propylamide. Grades: ≥98%. CAS No. 157182-49-5. Molecular formula: C23H39NO2. Mole weight: 361.6. | |
| R-268712 | R-268712 is a potent and selective inhibitor of TGF-β type I receptor/ALK5 with an IC50 of 2.5 nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK). It suppresses development of renal fibrosis in a unilateral ureteral obstruction model. It also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Synonyms: R-268712; R 268712; R268712. Grades: >98 %. CAS No. 879487-87-3. Molecular formula: C20H18FN5O. Mole weight: 363.39. | |
| (R)-3,4-DCPG | (R)-3,4-DCPG is an AMPA receptor antagonist with weak activity at NMDA receptors and no activity at kainate receptors. Synonyms: (R)-3,4-Dicarboxyphenylglycine; 4-[(1R)-1-Amino-2-hydroxy-2-oxoethyl]phthalic acid. Grades: ≥96% by HPLC. CAS No. 201730-10-1. Molecular formula: C10H9NO6. Mole weight: 239.18. | |
| (R)-3-Carboxy-4-hydroxyphenylglycine | (R)-3-Carboxy-4-hydroxyphenylglycine has been found to be an antagonist of NMDA and AMPA/kainate receptor. Synonyms: D-(3-Carboxy-4-hydroxyphenyl)glycine; (αR)-α-Amino-3-carboxy-4-hydroxybenzeneacetic Acid. Grades: ≥98% by HPLC. CAS No. 13861-03-5. Molecular formula: C9H9NO5. Mole weight: 211.17. | |
| (R)-4-Carboxyphenylglycine | (R)-4-Carboxyphenylglycine has been found to be a moderately potent NMDA receptor antagonist. Synonyms: (R)-4-(Amino(Carboxy)Methyl)Benzoic Acid. Grades: ≥98% by HPLC. CAS No. 134052-68-9. Molecular formula: C9H9NO4. Mole weight: 195.17. | |
| R547 | R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity. CDKI R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells. Synonyms: RO-4584820; RO4584820; RO 4584820. R 547; R547; R-547. Grades: >98%. CAS No. 741713-40-6. Molecular formula: C18H21F2N5O4S. Mole weight: 441.45. | |
| R 568 hydrochloride | R 568 is positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR), increasing the sensitivity to activation by extracellular Ca2+. It dose-dependently decreases circulating levels of PTH in both normal individuals and patients with primary hyperparathyroidism in clinical trials. R-568 is used in research to explore novel actions of CaSR. Synonyms: R 568 hydrochloride; R568 hydrochloride; R-568 hydrochloride; 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine hydrochloride; 2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine Hydrochloride (9CI); (R)-2-Chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine Hydrochloride; KRN 568; NPS-R 568; Norcalcin; R 568; R 568 (Pharmaceutical); Tecalcet Hydrochloride. Grades: ≥99% by HPLC. CAS No. 177172-49-5. Molecular formula: C18H22ClNO.HCl. Mole weight: 340.29. | |
| (R)-5-Hydroxy-DPAT hydrobromide | A weak dopamine D2 receptor antagonist. Synonyms: Hydroxy-DPAT hydrobromide, (R)-5-; (R)-5-OH-DPAT HBr. Grades: 98%. CAS No. 182210-73-7. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (R)-5-Hydroxymethyl tolterodine | 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. Synonyms: Desfesoterodine. Grades: >98%. CAS No. 207679-81-0. Molecular formula: C22H31NO2. Mole weight: 341.49. | |
| (R)-(+)-5-Methoxy-2-aminotetraline hydrochloride | (R)-(+)-5-Methoxy-2-Aminotetraline hydrochloride is a dopamine receptor agonist. Synonyms: (R)-5-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; Aminotetraline hydrochloride, (R)-(+)-5-Methoxy-2-. Grades: 95%. CAS No. 58349-15-8. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| (R)-5-Methoxy-N-propyl-2-aminotetraline hydrochloride | (R)-5-Methoxy-N-propyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist and an intermediate in the production of antipsychotic agents and antiparkinson drugs. Synonyms: (R)-1,2,3,4-Tetrahydro-5-methoxy-N-propyl-2-naphthalenamine Hydrochloride; (R)-5-methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine Hydrochloride; Aminotetraline hydrochloride, (R)-5-Methoxy-N-propyl-2-. Grades: 98%. CAS No. 93601-85-5. Molecular formula: C14H21NO.HCl. Mole weight: 255.78. | |
| R66905 | R66905, also known as saperconazole, is a broad-spectrum antifungal triazole. Synonyms: Saperconazole; SPZ; R66905; R-66905; R 66905; 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one; saperconazole. CAS No. 110588-57-3. Molecular formula: C35H38F2N8O4. Mole weight: 672.72. | |
| (R)-6-Hydroxybuspirone | (R)-6-Hydroxybuspirone is a major active metabolite of Buspirone. (R)-Enantiomer showed higher affinity and selectivity for the 5HT1A receptor compared to the (S)-enantiomer; while (S)-Enantiomer has advantage of being cleared more slowly from blood compared to the (R)-enantiomer. Uses: 5-ht1a partial agonist. Synonyms: BMS-442608; BMS 442608; BMS442608; UNII-93881477KV. 6-hydroxy-8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, (6R)-8-Azaspiro(4.5)decane-7,9-dione. Grades: ≥98%. CAS No. 477930-30-6. Molecular formula: C21H31N5O3. Mole weight: 401.5. | |
| (R)-6-Hydroxybuspirone hydrochloride | The salt form of (R)-6-hydroxybuspirone, which is an active metabolite of Buspirone. It is a 5-HT1A partial agonist with higher affinity for 5HT1A receptor compared to the (S)-enantiomer. Synonyms: Hydroxybuspirone hydrochloride, (R)-6-; BMS-442608 hydrochloride; (10R)-10-hydroxy-8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride. Grades: 99%. CAS No. 2108486-86-6. Molecular formula: C21H31N5O3.HCl. Mole weight: 437.96. | |
| (R)-6-Hydroxy-DPAT hydrobromide | A dopamine receptor agonist. Synonyms: Hydroxy-DPAT hydrobromide, (R)-6-; (R)-6-OH-DPAT HBr. Grades: 99%. CAS No. 1246094-81-4. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| R-7128 | R-7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes. It is a nucleoside polymerase inhibitor (NPI) and is able to inhibit the RNA synthesis of HCV in vitro. Synonyms: Mericitabine; PSI 6130 diisobutyrate; RG7128; RG-7128; RG 7128; R-7128; R7128; R 7128; PSI 6130 diisobutyrate; 3',5'-Diisobutyryl PSI 6130; Mericitabine. Grades: >98%. CAS No. 940908-79-2. Molecular formula: C18H26FN3O6. Mole weight: 399.41. | |
| (R)-(+)-7-Hydroxy-DPAT hydrobromide | A dopamine D3 receptor agonist with more potent activity in comparison with (S)-(-)-7-OH-DPAT. Synonyms: Hydroxy-DPAT hydrobromide, (R)-(+)-7-; (R)-(+)-7-OH-DPAT HBr. Grades: 98%. CAS No. 1021878-34-1. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (R)-7-Methoxy-2-aminotetraline hydrochloride | (R)-7-Methoxy-2-Aminotetraline hydrochloride is a dopamine receptor agonist. Synonyms: 7-Methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthaleneamine hydrochloride; (2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride; Aminotetraline hydrochloride, (R)-7-Methoxy-2-. Grades: 99%. CAS No. 170638-05-8. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| (R)-(+)-8-Hydroxy-DPAT hydrobromide | (R)-(+)-8-Hydroxy-DPAT hydrobromide is a full 5-HT1A serotonin receptor agonist. It decreases hippocampal 5-HT levels following systemic administration in rats in vivo. Synonyms: 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide (1:1), (7R)-; (R)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, monohydrobromide, (7R)-; 1-Naphthalenol, 7-(dipropylamino)-5,6,7,8-tetrahydro-, hydrobromide, (R)-; (+)-8-OH-DPAT hydrobromide; (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide; R(+)-8-Hydroxy DPAT HBr. Grades: ≥99% by HPLC. CAS No. 78095-19-9. Molecular formula: C16H25NO.HBr. Mole weight: 328.29. | |
| (R)-(+)-8-Methoxy-2-aminotetraline hydrochloride | (R)-(+)-8-Methoxy-2-Aminotetraline hydrochloride is a 5-HT1A agonist. Synonyms: Aminotetraline hydrochloride, (R)-(+)-8-Methoxy-2-; (2R)-8-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride. Grades: 98%. CAS No. 119363-61-0. Molecular formula: C11H15NO.HCl. Mole weight: 213.7. | |
| R916562 | R916562, a diaminotriazole compound, is a potential and selective Axl/VEGF-R2 dual inhibitor with IC50s of 136 and 24 nM, respectively. R916562 showed activity comparable to the clinically approved tyrosine kinase inhibitor Sunitinib in mouse tumor xenograft models and the corneal micropocket angiogenesis model. Synonyms: R916562; R 916562; R-916562. CAS No. 1037798-41-6. Molecular formula: C26H30ClN9S. Mole weight: 536.09. | |
| R-932348 | A dual JAK/SYK inhibitor that can be used to treat diseases and disorders of the eye. Synonyms: R-932348; R 932348; R932348; Propanamide, N-[[5-[[5-fluoro-4-[[4-(2-propyn-1-yloxy)phenyl]amino]-2-pyrimidinyl]amino]-2-methylphenyl]sulfonyl]-. CAS No. 916742-11-5. Molecular formula: C23H22FN5O4S. Mole weight: 483.52. | |
| R-96544 hydrochloride | Cas No. 167144-80-1. | |
| RA190 | RA190, a bis-benzylidine piperidon, is a novel potent and selective inhibitor of proteasome ubiquitin receptor RPN13/ADRM1. RA190 stabilized targets of human papillomavirus (HPV) E6 oncoprotein, and preferentially killed HPV-transformed cells. Synonyms: (3Z,5Z)-1-[(2S)-2-amino-3-phenylpropanoyl]-3,5-bis[(3,4-dichlorophenyl)methylidene]piperidin-4-one;hydrochloride; 3,5-bis(3,4-dichlorobenzylidene)-1-(S-2-amino-3-phenyl)-piperidin-4-one, HCl; RA190. CAS No. 1617495-03-0. Molecular formula: C28H23Cl5N2O2. Mole weight: 596.76. | |
| RA 839 | RA 839 is a selective inhibitor of the Keap1/Nrf2 interaction (Kd=6 uM) and a useful tool compound to study the biology of Nrf2. It binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM. RA 839 suppresses LPS-induced iNOS and nitric oxide expression in macrophages. Synonyms: (3S)-1-[4-[[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-3-pyrrolidinecarboxylic acid; RA-839; RA 839; RA839. Grades: ≥98% by HPLC. CAS No. 1832713-02-6. Molecular formula: C25H28N2O4S. Mole weight: 452.57. | |
| rac-3-Hexadecanamido-2-methoxypropan-1-ol Phosphocholine Monohydrate | The Pharmacological activity of this molecular is Growth Inhibition of Malignant Cells in vivo and in vitro and cytotoxic properties may result inhibition of protein kinase C activity. Uses: Cancer treatment. Synonyms: 4-Hydroxy-7-methoxy-N,N,N-trimethyl-10-oxo-3,5-dioxa-9-aza-4-phosphapentacosan-1-aminium Inner Salt 4-Oxide Hydrate; (+/-)-4-Hydroxy-7-methoxy-N,N,N-trimethyl- 10-oxo-3,5-dioxa-9-aza-4-phosphapentacosan-1-aminium Inner Salt 4-Oxide Hydrate,cas 112989-00-1. Grades: 95%. CAS No. 163751-35-7. Molecular formula: C25H55N2O7P. Mole weight: 526.69. | |
| rac BHFF | BHFF is a positive allosteric modulator of GABAB receptor that increases the potency and efficacy of GABA. BHFF displays anxiolytic activity in vivo. Synonyms: rac-BHFF; rac BHFF; racBHFF; 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone. Grades: ≥98% by HPLC. CAS No. 123557-91-5. Molecular formula: C17H21F3O3. Mole weight: 330.34. | |
| (Rac)-JBJ-04-125-02 | (Rac)-JBJ-04-125-02 is the racemate of JBJ-04-125-02. JBJ-04-125-02 is a mutation-selective EGFR allosteric inhibitor with potential anti-cancer activity. Grades: 98%. CAS No. 2140807-05-0. Molecular formula: C29H26FN5O3S. Mole weight: 543.6. | |
| Raclopride | Raclopride, also known as FLA 870, is a selective and potent dopamine D2/D3 receptor antagonist. It has high affinity (Kd = 1.2 nM) and high selectivity for D2 receptors in vitro and in vivo (IC50 = 32 nM). Uses: Antipsychotic agents. Synonyms: 3,5-Dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide; (-)-Raclopride; FLA 870; FLA870; FLA-870; Benzamide, 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxy-; Benzamide, 3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-6-methoxy-, (S)-; (S)-3,5-Dichloro-N-((1-ethylpyrrolidin-2-yl)methyl)-2-hydroxy-6-methoxybenzamide. Grades: ≥99% by HPLC. CAS No. 84225-95-6. Molecular formula: C15H20Cl2N2O3. Mole weight: 347.24. | |
| Ractopamine hydrochloride | Ractopamine hydrochloride, a phenethanolamine with beta-adrenergic agonist properties, has the effects of increasing muscle mass and decreasing body fat in rodents and lifestock. Synonyms: 4-Hydroxy-α-[[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]methyl]phenol hydrochloride; EL 737; LY 031537; EL-737; LY-031537; EL737; LY O31537; Optaflexx; Paylean; Topmax 9. Grades: ≥97% by HPLC. CAS No. 90274-24-1. Molecular formula: C18H23NO3.HCl. Mole weight: 337.84. | |
| Radafaxine Hydrochloride | The hydrochloride salt form of Radafaxine which is also an active metabolism of Bupropion and has been found to be an inhibitor of dopamine and norepinephrine transporter and a regulator of nAChR family. The Phase II trail has already been discontinued fo. Uses: The hydrochloride salt form of radafaxine which is also an active metabolism of bupropion and has been found to be an inhibitor of dopamine and norepinephrine transporter and a regulator of nachr family. Synonyms: Radafaxine hydrochloride; Radafaxine (hydrochloride); UNII-SYD411HZ3S; (2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride; SS-hydroxybupropion hydrochloride. Grades: 95%. CAS No. 106083-71-0. Molecular formula: C13H19Cl2NO2. Mole weight: 292.20. | |
| Radalbuvir | Radalbuvir is a Hepatitis C virus NS 5 protein inhibitor for the treatment of hepatitis C virus (HCV) infection developed by Gilead Sciences. In 2014, Gilead completed a phase II trial for Hepatitis C in USA. Uses: Hepatitis c. Synonyms: GS-9669; GS 9669; GS9669; Radalbuvir;5-(3,3-dimethyl-1-butyn-1-yl)-3-((cis-4-hydroxy-4-((((3S)-tetrahydro-3-furanyl)oxy)methyl)cyclohexyl)(((1R)-4-methyl-3-cyclohexen-1-yl)carbonyl)amino)- 2-Thiophenecarboxylic acid. Grades: 98%. CAS No. 1314795-11-3. Molecular formula: C30H41NO6S. Mole weight: 543.72. | |
| (R)-((addition))-Etomoxir sodium salt | (R)-((addition))-Etomoxir sodium salt is a potent inhibitor of carnitine palmitoyltransferase I (CPT1), which inhibits β-oxidation in mitochondria. It has shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells. Synonyms: (+)-Etomoxir sodium salt. Grades: >98%. CAS No. 828934-41-4. Molecular formula: C15H18ClNaO4. Mole weight: 320.74. | |
| Radezolid | Radezolid is a novel oxazolidinone antibiotic being developed by Rib-X Pharmaceuticals, Inc. for the treatment of serious multi-drug-resistant infections. It has completed two phase-II clinical trials. Uses: Anti-bacterial agents. Synonyms: RX-1741; RX 1741; RX1741; Radezolid. Grades: >98%. CAS No. 869884-78-6. Molecular formula: C22H23FN6O3. Mole weight: 438.45. | |
| Radiprodil | Radiprodil is an orally active and selective NMDA NR2B antagonist as a potential therapeutic agent in treatment of neuropathic pain and possibly other chronic pain conditions, blocking pain signaling without interacting with other NMDA receptor subtypes thus potentially improving therapeutic index and side effect profile. Uses: Nmda nr2b antagonist. Synonyms: RGH-896; RGH896; RGH 896; 2-(4-((4-Fluorophenyl)methyl)piperidin-1-yl)-2-oxo-N-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)acetamide. Grades: ≥98%. CAS No. 496054-87-6. Molecular formula: C21H20FN3O4. Mole weight: 397.41. | |
| RAF265 | RAF265 is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM. Synonyms: CHIR-265; RAF265; CHIR 265; RAF 265; CHIR265; RAF-265. Grades: >98%. CAS No. 927880-90-8. Molecular formula: C24H16F6N6O. Mole weight: 518.41. | |
| Rafabegron | Rafabegron is a potent and selective beta3-adrenoceptor agonist. Synonyms: 2-[[3-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]propyl]- 1H-indol-7-yl]oxy]acetic acid; TAK 677; TAK-677; TAK677; AD-9677; AD9677; AD 9677; AJ-9677; AJ-9677; AJ-9677; Rafabegron. Grades: >98%. CAS No. 244081-42-3. Molecular formula: C21H23ClN2O4. Mole weight: 402.875. | |
| Ralfinamide mesylate | Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents. It displays analgesic effects in animal models of inflammatory and neuropathic pain. Synonyms: (2S) -2-[[[4-[ (2-Fluorophenyl) methoxy]phenyl]methyl]amino]-propanamide methanesulfonate. Grades: ≥99% by HPLC. CAS No. 202825-45-4. Molecular formula: C17H19FN2O2.CH3SO3H. Mole weight: 398.45. | |
| (R)-(-)-alpha-Methylhistamine dihydrobromide | (R)-(-)-alpha-Methylhistamine dihydrobromide is a potent and high affinity histamine H3 agonist (KD = 50.3 nM) displaying > 200-fold selectivity over H4 receptors. It inhibits H3-mediated histamine synthesis and release in the CNS at nanomolar concentrations, and induces H4-mediated eosinophil shape change (EC50 = 66 nM). Synonyms: (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide. Grades: ≥99% by HPLC. CAS No. 868698-49-1. Molecular formula: C6H11N3.2HBr. Mole weight: 287. | |
| R-(?)-α-Methylhistamine hydrochloride | R-(-)-α-Methylhistamine is a histamine H3 receptor agonist that inhibits the synthesis and release of histamine. Synonyms: (R)-1-(1H-Imidazol-4-yl)propan-2-amine dihydrochloride. Grades: ≥95%. CAS No. 75614-89-0. Molecular formula: C6H11N3·2HCl. Mole weight: 198.1. | |
| (R)-AMPA | (R)-AMPA is an inactive enantiomer of AMPA, which has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor. Synonyms: (R)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. Grades: ≥99% by HPLC. CAS No. 83654-13-1. Molecular formula: C7H10N2O4. Mole weight: 186.17. | |
| Raniestat | Raniestat, a highly potent aldose reductase inhibitor currently under phase III clinical trials in the US and Canada, is used to treat diabetic neuropathies. Uses: Enzyme inhibitors. Synonyms: (3R) -2'-[ (4-bromo-2-fluorophenyl) methyl]spiro[pyrrolidine-3, 4'-pyrrolo[1, 2-a]pyrazine]-1', 2, 3', 5-tetroneRanirestatAS-3201; AS 3201; AS3201CHEMBL334830147254-64-6SX-3202RaniestatSX 3030; SX3030SX-3030Ranirestat (JAN/INN)AC1L4BEUUNII-Z26P56GFTVZ26P56GFTVSCHEMBL498993D. CAS No. 147254-64-6. Molecular formula: C17H11BrFN3O4. Mole weight: 420.19. | |
| Raseglurant | Raseglurant is a negative allosteric modulator of the mGlu5 receptor and derivative of MPEP. It can be used for the treatment of migraine, gastroesophageal reflux disease, and dental anxiety. Phase II clinical trials for all of the aforementioned indications were discontinued due to the observation of possible predictive signs of hepatotoxicity in patients with long-term use. Uses: Migraine, gastroesophageal reflux disease, and dental anxiety. Synonyms: ADX10059; ADX 10059; ADX-10059; 2-[(3-Fluorophenyl)ethynyl]-4,6-dimethyl-3-pyridinamine. Grades: 98%. CAS No. 757950-09-7. Molecular formula: C15H13FN2. Mole weight: 240.28. | |
| (R)-(+)-Atenolol | (R)-(+)-Atenolol is the less active enantiomer of the racemic β1-adrenergic receptor antagonist, (R,S)-atenolol. Synonyms: (+)-Atenolol; R(+)-Atenolol. Grades: ≥98%. CAS No. 56715-13-0. Molecular formula: C14H22N2O3. Mole weight: 266.3. | |
| Ratester | Radester is a hybrid composed of radicicol's resorcinol and geldanamycin's benzoquinone part structures and exhibits good cellular activity against MCF7 breast cancer cells, accompanied by degradation of the Hsp90 clients HER-2 and c-Raf. Synonyms: CHEMBL578372; CHEMBL 578372; CHEMBL-578372; SCHEMBL10186763; SCHEMBL 10186763; SCHEMBL-10186763. Grades: >98%. CAS No. 854485-83-9. Molecular formula: C18H16ClNO8. Mole weight: 409.77. | |
| Rauwolscine hydrochloride | Rauwolscine hydrochloride is the hydrochloride salt of Rauwolscine which is a potent, reversible and specific α2 adrenergic receptor antagonist with a Ki values are 3.5, 4.6, and 0.6 nM at cloned human α2A-AR, α2B-AR, and α2C-AR adrenoceptors, respectively. It also acts as a 5-HT2B receptor antagonist and has the function to modulate mood. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: methyl (1S,15S,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;hydrochloride; alpha-Yohimbine hydrochloride; Fauwolscine, hydrochloride; alpha-Yohimbin hydrochloride; NSC 407307; Rauwolscine (hydrochloride); Methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate hydrochloride. CAS No. 6211-32-1. Molecular formula: C21H27ClN2O3. Mole weight: 390.9. | |
| Ravidasvir HCl | Avidasvir is a second-generation Hepatitis C virus NS 5 protein inhibitor. In Sep 2016, Phase-II/III clinical trials in Hepatitis C in Malaysia was on-going. Uses: Hepatitis c. Synonyms: PPI-668; PPI 668; PPI668; ASC16; ASC-16; ASC 16; BI238630; C5; Ravidasvir dihydrochloride;methyl N-[(2S)-1-{(2S)-2-[5-(6-{2-[(2S)-1-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl]-1H-imidazol-4-yl}naphthalen-2-yl)-1H-benzimidazol-2-yl]pyrrolidin-1-yl}-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride. Grades: 98%. CAS No. 1303533-81-4. Molecular formula: C42H52Cl2N8O6. Mole weight: 835.83. | |
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