BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SAG dihydrochloride | SAG is a potent and cell-permeable Smoothened (Smo) receptor agonist that regulates hedgehog signaling. SAG inhibits hedgehog signaling at high concentrations. Synonyms: 3-Chloro-N-[trans-4- (methylamino) cyclohexyl]-N-[[3- (4-pyridinyl) phenyl]methyl]benzo[b]thiophene-2-carboxamide dihydrochloride. Grades: ≥99% by HPLC. Molecular formula: C28H28ClN3OS.2HCl. Mole weight: 562.98. |  |
| SAH-EZH2 | SAH-EZH2 is an EZH2/EED interaction inhibitor (Kd = 320 nM). It selectively inhibits H3 Lys27 trimethylation by dose-responsively disrupting the EZH2/EED complex and reducing EZH2 protein levels. CAS No. 1453222-26-8. Molecular formula: C155H256N48O40. Mole weight: 3432.05. | |
| SAHM1 | SAHM1 is a cell-permeable, stabilized hydrocarbon-stapled alpha helical peptide acting as a Notch pathway inhibitor. CAS No. 2050906-89-1. Molecular formula: C94H162N36O23S. Mole weight: 2196.58. | |
| SAK 3 | SAK 3 is a potent CaV3.1 and CaV3.3 activator. It enhances ACh release in hippocampus. It rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Synonyms: SAK-3; SAK3; Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate. Grades: ≥98% by HPLC. CAS No. 1256269-87-0. Molecular formula: C20H23N3O4. Mole weight: 369.41. | |
| Salermide | Salermide is a SIRT1 and SIRT2 inhibitor displaying a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. The sirtuins (SIRTs) are a family of NAD+-dependent histone deacetylases. Salermide induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours. Synonyms: N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide. Grades: ≥98% by HPLC. CAS No. 1105698-15-4. Molecular formula: C26H22N2O2. Mole weight: 394.47. | |
| Salifungin | Salifungin is an antifungal agent. Synonyms: Multifungin; Bromosalicylchloranilide; 5-Bromo-4'-chlorosalicylanilide; 5-Bromo-N-(4-chlorophenyl)-2-hydroxybenzamide. CAS No. 3679-64-9. Molecular formula: C13H9BrClNO2. Mole weight: 326.57. | |
| Salmefamol | Salmefamol is a beta2-adrenoceptor agonist which is useful for treatment of respiratory diseases. Synonyms: 4-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]-2-(hydroxymethyl)phenol; 1-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-(4-methoxy-alpha-methylphenethylamino)ethanol; AH 3923; AH3923; AH-3923; salmefamol; salmefamol, sulfate salt. Grades: >98%. CAS No. 18910-65-1. Molecular formula: C19H25NO4. Mole weight: 331.41. | |
| (S)-(+)-α-Methylhistamine dihydrobromide | (S)-(+)-α-Methylhistamine dihydrobromide is the less active enantiomer of histamine H3 receptor agonist R-(-)-α-methylhistamine, with 120-fold less potent than R-(-) at H3. Synonyms: (S)-(+)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide; (S)-a-Methyl-1H-imidazole-4-ethanamine; (aS)-a-Methyl-1H-imidazole-4-ethanamine (9CI); (aS)-a-Methyl-1H-imidazole-5-ethanamine; (S)-a-Methylhistamine; S-(+)-a-Methylhistamine. CAS No. 75614-93-6. Molecular formula: C6H11N3.2HBr. Mole weight: 287. | |
| (±)-Salsolinol hydrochloride | (±)-Salsolinol is a metabolite of ethanol produced by the condensation of dopamine with acetaldehyde in the brain. It is thought to contribute to some aspects of alcohol's addictive properties in part through its ability to stimulate dopamineric neurons in the posterior ventral tegmental area of the brain. Synonyms: (+-)-Salsolinol hydrochloride; Salsolinol hydrochloride, (+/-)-; 1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-6,7-diol chloride. Grades: ≥99%. CAS No. 79923-51-6. Molecular formula: C10H13NO2·HCl. Mole weight: 215.7. | |
| (S)-AMPA | (S)-AMPA is an active enantiomer of AMPA, which has been found to be a definitive agonist of the AMPA glutamatergic ionotropic receptor. Synonyms: (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid. Grades: ≥99% by HPLC. CAS No. 83643-88-3. Molecular formula: C7H10N2O4. Mole weight: 186.17. | |
| Sanguinarine chloride hydrate | Cas No. 5578-73-4. | |
| Sansalvamide A | Sansalvamide A binds directly to Hsp90 and modulate Hsp90's binding with client proteins. Grades: >98%. CAS No. 227084-43-7. Molecular formula: C32H50N4O6. Mole weight: 586.76. | |
| SANT-2 | SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling and an antagonist of smoothened receptor activity (KD = 12 nM). SANT-2 exhibits smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki = 7.8 nM and 8.4 nM, respectively). Synonyms: SANT-2; SANT 2; SANT2; N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide. Grades: ≥98% by HPLC. CAS No. 329196-48-7. Molecular formula: C26H26ClN3O4. Mole weight: 479.96. | |
| Saquinavir | An HIV protease inhibitor. It is often used in combination with ritonavir or lopinavir/ritonavir for HIV/AIDS infection therapy. Uses: Hiv protease inhibitors. Synonyms: Invirase; Fortovase; saguinavir; Ro 31-8959; Ro 31 8959; Ro318959. Grades: ≥98%. CAS No. 127779-20-8. Molecular formula: C38H50N6O5. Mole weight: 670.8. | |
| SAR-020106 | SAR-020106 is an ATP-competitive, potent, and selective CHK1 inhibitor on the isolated human enzyme. This compound abrogates an etoposide-induced G(2) arrest with an IC(50) of 55 nmol/L in HT29 cells, and significantly enhances the cell killing of gemcitabine and SN38 by 3.0- to 29-fold in several colon tumor lines in vitro and in a p53-dependent fashion. Biomarker studies have shown that SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo. SAR-020106 can enhance antitumor activity with selected anticancer drugs in vivo and may therefore have clinical utility. Synonyms: SAR020106; SAR 020106; SAR-20106; SAR20106; SAR 20106. Grades: 98%. CAS No. 1184843-57-9. Molecular formula: C19H19ClN6O. Mole weight: 382.852. | |
| SAR131675 | SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD, with an IC50 of about 20 nM. Synonyms: (R)-2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide; 1,8-Naphthyridine-3-carboxamide, 2-amino-1-ethyl-1,4-dihydro-7-[(3R)-3-hydroxy-4-methoxy-3-methyl-1-butyn-1-yl]-N-methyl-4-oxo-. Grades: >98%. CAS No. 1433953-83-3. Molecular formula: C18H22N4O4. Mole weight: 358.39. | |
| SAR156497 | SAR156497 is a selective Aurora A, B and C inhibitor with in vitro and in vivo efficacy IC50 value is 0.5 nM for Aurora A; 1.0 nM for Aurora B (incenp) and 3.0 nM for Aurora C (incenp). In vitro, SAR156497 shows very good antiproliferative activity on a large panel of tumor cell lines. Uses: Anti-tumor. Synonyms: SAR156497; SAR156497; SAR 156497. Grades: 98%. CAS No. 1256137-14-0. Molecular formula: C27H24N4O4. Mole weight: 468.5. | |
| SAR191801 | SAR191801 is a hPGDS inhibitor and the IC50 value of which is 12 nM that was determined through fluorescence polarization. Uses: Sar191801 is a hpgds inhibitor. Synonyms: SAR 191801; SAR-191801; SAR191801;HPGDS-IN-1; SCHEMBL2493135; 1234708-04-3; C22H20N6O3; 2-Pyridin-2-yl-pyrimidine-5-carboxylic acid 3-[5-(1-hydroxy-1-methyl-ethyl)-1,2,4-oxadiazol-3-yl]-benzylamide; N-(3-(5-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-3-yl)benzyl)-2-(pyridin-2-yl)pyrimidine-5-c. Grades: 98%. CAS No. 1234708-04-3. Molecular formula: C22H20N6O3. Mole weight: 416.43. | |
| SAR 216471 hydrochloride | SAR 216471 hydrochloride is a potent and reversible P2Y12 antagonist (IC50 = 17 nM), displaying antiplatelet and antithrombotic activity in vivo. Synonyms: SAR 216471 hydrochloride; SAR-216471 hydrochloride; SAR216471 hydrochloride; 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1279829-64-9. Molecular formula: C28H31ClN8O3.HCl. Mole weight: 599.51. | |
| SAR405838 | MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1. Synonyms: SAR-405838; SAR 405838; SAR405838; MI-773; MI773; MI 773. Grades: >98%. CAS No. 1303607-60-4. Molecular formula: C29H34Cl2FN3O3. Mole weight: 562.50. | |
| SAR-407899 | SAR-407899 is a potent, ATP-competitive ROCK inhibitor. It is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. It is highly selective in panel of 117 receptor and enzyme targets in vitro. It demonstrated concentration-dependent inhibition of Rho-kinase-mediated phosphorylation of myosin phosphatase, platelet-derived growth factor-induced proliferation, thrombin-induced stress fiber formation, and monocyte chemotactic protein-1-stimulated chemotaxis in vitro. It potently inhibits endothelin-1-induced constriction of renal resistance arteries. It has good antihypertensive activity and lowered blood pressure in a variety of rodent models. Uses: Sar-407899 has good antihypertensive activity. Synonyms: SAR407899; SAR 407899; SAR-407899; 6-Piperidin-4-yloxy-2H-isoquinolin-1-one;6-(Piperidin-4-yloxy)isoquinolin-1(2H)-one. Grades: >98 %. CAS No. 923359-38-0. Molecular formula: C14H16N2O2. Mole weight: 244.29. | |
| SAR-407899 hydrochloride | SAR-407899 hydrochloride is the hydrochloride form of SAR-407899, which is a potent, ATP-competitive ROCK inhibitor. It has good antihypertensive activity. Uses: Sar-407899 hydrochloride has good antihypertensive activity. Synonyms: 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one hydrochloride; SAR407899; SAR 407899; SAR-407899; SAR407899 HCl. Grades: >98%. CAS No. 923262-96-8. Molecular formula: C14H17ClN2O2. Mole weight: 280.75. | |
| SAR7334 hydrochloride | The hydrochloride salt form of SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC. Uses: The hydrochloride salt form of sar7334 is a trpc6 inhibitor that could be valuable in studying sorts of diseases related to trpc. Synonyms: SAR7334 hydrochloride; CPA1588 hydrochloride; SAR 7334 hydrochloride; CPA 1588 hydrochloride; SAR-7334 hydrochloride; CPA-1588 hydrochloride; 4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile; 1333207-63-8; 1333210-07-3; C21H22ClN3O. Grades: 97%. CAS No. 1333207-63-8. Molecular formula: C21H24Cl3N3O. Mole weight: 440.79. | |
| Saracatinib Difumarate | Saracatinib Difumarate is a tyrosine kinase inhibitor selectively targeting Src and Abl, which are commonly overexpressed in chronic myeloid leukema cells. Synonyms: AZD 0530 difumarate; AZD0530 difumarate; AZD-0530 difumarate; (E)-but-2-enedioic acid;N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(oxan-4-yloxy)quinazolin-4-amine. Grades: 99%. CAS No. 893428-72-3. Molecular formula: C27H32ClN5O5.2C4H4O4. Mole weight: 774.17. | |
| Sarafotoxin S6a | Sarafotoxin S6a is an endothelin receptor agonist (EC50 = 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta, respectively). CAS No. 126738-34-9. Molecular formula: C105H156N28O34S5. Mole weight: 2514.85. | |
| Sarafotoxin S6b | Sarafotoxin S6b is a non-selective endothelin receptor agonist with vasoconstrictor activity. CAS No. 116303-65-2. Molecular formula: C110H159N27O34S5. Mole weight: 2564. | |
| Sar-[D-Phe8]-des-Arg9-Bradykinin | Sar-[D-Phe8]-des-Arg9-Bradykinin is a potent and selective bradykinin B1 receptor agonist (EC50 = 9.02 nM in rabbit aorta) that is resistant to aminopeptidase, kininase I and II (ACE) and neutral endopeptidase cleavage. It shows hypotensive and angiogenic activity in vivo. Uses: Hypotensive agent. Synonyms: Sar[DPhe8][des-Arg9]BK; [N-methylglycine,D-Phe8,des-Arg9]bradykinin. CAS No. 126959-88-4. Molecular formula: C47H66N12O11. Mole weight: 975.11. | |
| Sarizotan HCl | Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa-induced dyskinesia. Synonyms: 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]-N-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]methanamine;hydrochloride; EMD128130; sarizotan; 177976-12-4 (Sarizotan 2 HCl salt); 351862-32-3 (Sarizotan free base); sarizotan hydrochloride. Grades: >98%. CAS No. 195068-07-6. Molecular formula: C22H22ClFN2O. Mole weight: 384.88. | |
| Saroglitazar | Saroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity as a drug for the treatment of diabetic dyslipidemia and hypertriglyceridemia with Type 2 diabetes mellitus not controlled by statin therapy. Synonyms: Lipaglyn; ZY-H1; (αS)-α-Ethoxy-4-[2-[2-methyl-5-[4-(methylthio)phenyl]-1H-pyrrol-1-yl]ethoxy]benzenepropanoic Acid. Grades: ≥98%. CAS No. 495399-09-2. Molecular formula: C25H29NO4S. Mole weight: 439.57. | |
| Saroglitazar (Magnesium) | Saroglitazar magnesium is a dual PPAR agonist with potent predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. The first glitazar to be granted marketing authorization in India. CAS No. 1639792-20-3. Molecular formula: C50H56MgN2O8S2. Mole weight: 901.43. | |
| Sarpogrelate | Sarpogrelate is a drug under the development of Mitsubishi Chemical as 5HT2A and 5-HT2B receptor. antagonists. It is used as an antiplatelet agent and has been applicated for the treatment of many diseases including coronary artery disease, diabetes mellitus, Buerger's disease, angina pectoris, Raynaud's disease, and atherosclerosis. Uses: Used as an antiplatelet agent. Synonyms: (-)-4-[1-dimethylamino-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid;135159-51-2 (HCl). Grades: 95%. CAS No. 125926-17-2. Molecular formula: C24H31NO6. Mole weight: 429.51. | |
| (S)-(-)-Atenolol | (S)-(-)-Atenolol is the active enantiomer of (RS)-atenolol, which is a cardioselective β-adrenergic blocker. It has antihypertensive, antianginal, antiarrhythmic (class II) effects. Synonyms: (S)-Atenolol; 4-[ (2S) -2-Hydroxy-3-[ (1-methylethyl) amino]propoxy]benzeneacetamide; (-)-Atenolol; Esatenolol; (S) - (-) -4-[2-Hydroxy-3-[ (1-methylethyl) amino]propoxy]benzeneacetamide; (-) -4-[2-Hydroxy-3-[ (1-methylethyl) amino]propoxy]benzeneacetamide. Grades: ≥97% by HPLC. CAS No. 93379-54-5. Molecular formula: C14H22N2O3. Mole weight: 266.34. | |
| Sauvagine | Sauvagine is a corticotropin-releasing factor (CRF) receptor agonist (Ki = 9.4, 9.9, and 3.8 nM for inhibition of 125I-[D-Tyr1]astressin binding to hCRF-R1, rCRF-R2a and mCRF-R2b, respectively). Synonyms: H-Pyr-Gly-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Ser-Leu-Glu-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2. Grades: >96%. CAS No. 74434-59-6. Molecular formula: C202H346N56O63S. Mole weight: 4599.35. | |
| Saxagliptin | Saxagliptin is a drug which was developed for the treatment of respiratory disorders such as asthma and Chronic Obstructive Pulmonary Disease (COPD). It is orally active and acts as a selective Phosphodiesterase-4 inhibitor. Uses: Dipeptidyl-peptidase iv inhibitors. Synonyms: BMS-477118; BMS 477118; BMS477118; Onglyza. Grades: 0.98. CAS No. 361442-04-8. Molecular formula: C18H25N3O2. Mole weight: 315.417. | |
| Saxagliptin hydrochloride | Saxagliptin is a potent and selective inhibitor of dipeptidyl peptidase 4 (DPP-4). It has been approved for the treatment of type 2 diabetes. It was shown to prevent the inactivation of the incretin hormones GLP-1 and glucose-dependent insulinotropic polypeptide, thus promoting insulin secretion. Synonyms: Saxagliptin HCl; BMS-477118; (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-1-adamantyl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrochloride. Grades: ≥98%. CAS No. 709031-78-7. Molecular formula: C18H25N3O2·HCl. Mole weight: 351.9. | |
| Sazetidine A hydrochloride | Sazetidine A hydrochloride is an α4β2 nicotinic acetylcholine receptor ligand (Ki = 0.26 and 54 nM at α4β2 and α3β4 receptors, respectively), displaying analgesic activity in vivo. Sazetidine A hydrochloride may act as a silent desensitizer or an agonist. Synonyms: 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1197329-42-2. Molecular formula: C15H20N2O2.HCl. Mole weight: 296.797. | |
| SB 200646 hydrochloride | SB 200646 hydrochloride is an orally bioactive 5-HT2C/2B receptor antagonist displaying selectivity over 5-HT1A. Synonyms: SB 200646 hydrochloride; SB200646 hydrochloride; SB-200646 hydrochloride; N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea; 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea hydrochloride. Grades: ≥98% by HPLC. CAS No. 143797-62-0. Molecular formula: C15H14N4O.HCl. Mole weight: 302.76. | |
| SB 202190 hydrochloride | SB 202190 is a potent, selective, and cell-permeable inhibitor of p38 MAP kinases, effective against p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC50 values of 50 and 100 nM, respectively. It inhibits p38 MAP kinases, resulting in blockade of tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) production in monocytes. Synonyms: SB 202190 HCl; 4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1H-imidazol-2-yl]phenol hydrochloride. Grades: ≥98%. CAS No. 350228-36-3. Molecular formula: C20H14FN3O·HCl. Mole weight: 367.8. | |
| SB 202474 | SB 202474 is an analog of SB 202190 and SB 203580, which are inhibitors of the MAP kinases p38α and p38&beta. SB 202474 has been used as a negative control in studies of p38 inhibition. Synonyms: SB-202474; SB202474; 4-[5-ethyl-2-(4-methoxyphenyl)-1H-imidazol-4-yl]pyridine. Grades: ≥97%. CAS No. 172747-50-1. Molecular formula: C17H17N3O. Mole weight: 279.3. | |
| SB 203186 hydrochloride | SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors. Synonyms: SB 203186 HCl; SB 203186 HCl; SB203186; SB-203186. 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride. Grades: ≥99% by HPLC. CAS No. 207572-69-8. Molecular formula: C16H20N2O2.HCl. Mole weight: 308.81. | |
| SB 204070 | SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1), displaying >5000-fold selectivity over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors. SB 204070 exhibits anxiolytic activity upon systemic administration in vivo. Uses: Serotonin antagonists. Synonyms: 1,4-Benzodioxin-5-carboxylic acid, 8-amino-7-chloro-2,3-dihydro-, (1-butyl-4-piperidinyl)methyl ester; (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-2,3-dihydro-1,4-benzodioxin-5-carboxylate; (1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate; SB204070; SB-204070; (1-Butylpiperidin-4-yl)methyl 8-amino-7-chloro-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylate. Grades: ≥95%. CAS No. 148702-58-3. Molecular formula: C19H27ClN2O4. Mole weight: 382.88. | |
| SB 204741 | SB 204741 is a potent and selective 5-HT2B receptor antagonist (pA2 = 7.95) with ≥ 135-fold selectivity over 5-HT2C (pKi = 5.82), 5-HT2A (pKi < 5.2), 5-HT1A, 1D, 1E, 5-HT3 and 5-HT4 receptors. Synonyms: SB 204741; SB204741; SB-204741. N-(1-Methyl-1H-indolyl-5-yl)-N''-(3-methyl-5-isothiazolyl)urea; 1-(1-methyl-1H-indol-5-yl)-3-(3-methylisothiazol-5-yl)urea. Grades: ≥99% by HPLC. CAS No. 152239-46-8. Molecular formula: C14H14N4OS. Mole weight: 286.35. | |
| SB 205384 | SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibits little effect on receptors which contains α1 or α2 subunits. Synonyms: SB 205384; SB-205384; SB205384. 4-Amino-5,6,7,8-tetrahydro-7-hydroxy-2-methyl-[1H]benzothieno[2,3-b]pyridine-3-carboxylic acid 2-butynyl ester. Grades: ≥98% by HPLC. CAS No. 160296-13-9. Molecular formula: C17H18N2O3S. Mole weight: 330.4. | |
| SB 205607 dihydrobromide | SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with high affinity and selectivity for the δ1 subtype (Ki = 1.12, 2320 and 1790 nM at δ1, μ and κ receptors, respectively). Synonyms: TAN67; TAN-67; TAN 67; SB-205607 dihydrobromide; SB 205607 dihydrobromide; SB205607 dihydrobromide; SB 205607 2HBr; SB205607 2HBr; SB-205607 2HBr; (R*,S*)-(±)-2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12aa-octahydroquinolino[2,3,3-g]isoquinoline dihydrobromide. Grades: ≥97% by HPLC. CAS No. 1217628-73-3. Molecular formula: C23H24N2O.2HBr. Mole weight: 506.28. | |
| SB 206553 hydrochloride | SB 206553 hydrochloride is a potent and selective 5-HT2B/5-HT2C receptor antagonist (rat 5-HT2B pA2=8.89, human 5-HT2C pKi=7.92) with > 80-fold selectivity over all other 5-HT receptor subtypes and a variety of other receptors (pKi < 6). Synonyms: SB 206553 HCl; SB 206553; SB206553; SB-206553; 3,5-Dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']dipyrrole-1(2H)-carboxamide hydrochloride; 1-methyl-N-pyridin-3-yl-6,7-dihydropyrrolo[2,3-f]indole-5-carboxamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1197334-04-5. Molecular formula: C17H16N4O.HCl. Mole weight: 328.8. | |
| SB-209670 | SB-209670 has been found to be an endothelin receptor antagonist that was once studied against arrhythmias and hypertension. Synonyms: SCHEMBL4197810; L001486; (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid; SB-209670; SB 209670; SB209670. Grades: 98%. CAS No. 157659-79-5. Molecular formula: C29H28O9. Mole weight: 520.53. | |
| SB 215505 | SB 215505 is a potent and orally bioactive 5-HT2B/2C receptor antagonist (pKi = 8.3, 7.66 and 6.77 for 5-HT2B, 5-HT2C and 5-HT2A, respectively). SB 215505 increases wakefulness and motor activity in rats. Synonyms: SB215505; SB 215505; SB-215505. 6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide. Grades: ≥98% by HPLC. CAS No. 162100-15-4. Molecular formula: C19H16ClN3O. Mole weight: 337.81. | |
| SB 216641 hydrochloride | SB 216641 hydrochloride is a selective h5-HT1B antagonist with ~ 25-fold selectivity over h5-HT1D and little or no affinity for a range of other receptor types. Synonyms: SB216641 hydrochloride; SB-216641 hydrochloride; N-[3-[2-(Dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-carboxamide Monohydrochloride; [1,1'-Biphenyl]-4-carboxamide, N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, hydrochloride (1:1); [1,1'-Biphenyl]-4-carboxamide, N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-, monohydrochloride; SB 216641A; SB216641A; SB-216641A. Grades: ≥98% by HPLC. CAS No. 193611-67-5. Molecular formula: C28H30N4O4.HCl. Mole weight: 523.03. | |
| SB 218795 | SB 218795 is a potent and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3) displaying 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. SB 218795 inhibits agonist-induced pupillary constriction. Synonyms: SB-218795; SB218795; SB 218795; (R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid; methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate. Grades: ≥99% by HPLC. CAS No. 174635-53-1. Molecular formula: C25H20N2O3. Mole weight: 396.44. | |
| SB 221284 | SB 221284 is a potent and selective 5-HT2C/2B receptor antagonist (pKi = 6.4, 7.9 and 8.6 for 5-HT2A, 2B and 2C receptors, respectively). Synonyms: SB 221284; SB221284; SB-221284. 2,3-Dihydro-5-(methylthio)-N-3-pyridinyl-6-(trifluoromethyl)-1H-indole-1-carboxamide. Grades: ≥99% by HPLC. CAS No. 196965-14-7. Molecular formula: C16H14F3N3OS. Mole weight: 353.36. | |
| SB 222200 | SB 222200 is a brain penetrating and non-peptide NK3 receptor antagonist (Ki = 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors, respectively) that exhibits antihypertensive activity in vivo. Synonyms: SB-222200; SB222200; SB 222200; 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 174635-69-9. Molecular formula: C26H24N2O. Mole weight: 380.48. | |
| SB 223412 | SB 223412 is a brain penetrating and orally bioactive non-peptide NK3 receptor antagonist (Ki = 1, 144 and >100000 nM for human NK3, NK2 and NK1 receptors, respectively). SB 223412 was shown to inhibit NKB-induced Ca2+ mobilization in vitro (IC50 = 16.6 nM) and NK3-agonist-induced behavioral responses in vivo. SB 223412 can be used as an antispychotic. Synonyms: SB 223412; SB223412; SB-223412; 3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide; 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 174636-32-9. Molecular formula: C25H22N2O2. Mole weight: 382.45. | |
| SB 224289 hydrochloride | SB 224289 hydrochloride is a selective 5-HT1B receptor antagonist (pKi = 8.2) displaying > 60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. SB 224289 exhibits anxiolytic activity. Synonyms: SB224289 hydrochloride; SB-224289 hydrochloride; 1'-Methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperidine hydrochloride; [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone hydrochloride; Methanone, [2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)-, hydrochloride (1:1); Spiro[2H-furo[2,3-f]indole-3(5H),4'-piperidine], 6,7-dihydro-1'-methyl-5-[[2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]carbonyl]-, monohydrochloride; SB 224289A; SB224289A; SB-224289A. Grades: ≥95% by HPLC. CAS No. 180084-26-8. Molecular formula: C32H32N4O3.HCl. Mole weight: 557.09. | |
| SB225002 | SB225002 is a potent and selective non-peptide inhibitor of CXCR2 with IC50 of 22 nM. Synonyms: N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea; SB 225002; SB-225002. CAS No. 182498-32-4. Molecular formula: C13H10BrN3O4. Mole weight: 352.14. | |
| SB 228357 | SB 228357 is a 5-HT2C/2B receptor antagonist (pKi = 7.0, 8.1 and 9.1 at 5-HT2A, 2B and 2C receptors, respectively) used in the treatment of irritable bowel syndrome (IBS). SB 228357 shows inverse agonism in a 5-HT-stimulated PI hydrolysis model of 5-HT2C receptor function. Uses: The treatment of irritable bowel syndrome (ibs). Synonyms: SB-228357; SB 228357; SB228357. N-[3-Fluoro-5-(3-pyrindyl)phenyl]-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide. Grades: ≥99% by HPLC. CAS No. 181629-93-6. Molecular formula: C22H17F4N3O2. Mole weight: 431.39. | |
| SB 242084 | SB 242084 is a brain-penetrant antagonist of 5-HT2C receptor which exhibits 158-fold selectivity for 5-HT2C (pKi= 9.0) over 5-HT2A receptor (pKi= 6.1-6.8) and 100-fold selectivity over 5-HT2B receptor (pKi= 6.8-7.0). Synonyms: SB 242084; SB242084; SB-242084; 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride181632-25-76-Chloro-5-methyl-N-(6-((2-methylpyridin-3-yl)oxy)pyridin-3-yl)indoline-1-carboxamide dihydrochlorideSB 242084 (hydrochloride)6-chl. CAS No. 181632-25-7. Molecular formula: C21H19ClN4O2. Mole weight: 394.85. | |
| SB-242084 HCl salt | SB-242084 is a psychoactive drug and research chemical which acts as a selective antagonist for the 5HT2C receptor. It can increase the effectiveness of the selective serotonin reuptake inhibitor (SSRI) class of antidepressants, and may also reduce their side effects. Synonyms: SB-242084; SB 242084; SB242084; SB-242084 HCl. Grades: 98%. CAS No. 1049747-87-6. Molecular formula: C21H21Cl3N4O2. Mole weight: 467.78. | |
| SB 242084 hydrochloride | SB 242084 hydrochloride is a selective and brain penetrant 5-HT2C receptor antagonist with over 100-fold selectivity versus a range of other 5-HT, dopamine and adrenergic receptors. Synonyms: SB 242084 hydrochloride; SB242084 hydrochloride; SB-242084 hydrochloride; 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide hydrochloride. Grades: 99%. CAS No. 1260505-34-7. Molecular formula: C21H19ClN4O2.HCl. Mole weight: 431.32. | |
| SB-242235 | SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 1.0 uM. Synonyms: SB-242235; SB242235. Grades: 0.99. CAS No. 193746-75-7. Molecular formula: C18H17N5O3. Mole weight: 353.401. | |
| SB 243213 dihydrochloride | SB 243213 dihydrochloride is a 5-HT2C inverse agonist (pKb = 9.8) with selectivity over other 5-HT2 subtypes (pKi = 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively). SB 243213 exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. SB 243213 shows anxiolytic activity in rat models. Synonyms: SB 243213 dihydrochloride; SB 243213 dihydrochloride; SB 243213 dihydrochloride; 2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 200940-23-4. Molecular formula: C22H19F3N4O2.2HCl. Mole weight: 501.33. | |
| SB 258585 hydrochloride | SB 258585 hydrochloride is a potent and selective 5-HT6 receptor antagonist (pKi = 8.6) with > 160-fold selectivity over other 5-HT receptor subtypes, dopamine and α-adrenergic receptors. Synonyms: SB 258585 hydrochloride; SB258585 hydrochloride; SB-258585 hydrochloride; 4-Iodo-N-[4-methoxy-3- (4-methyl-1-piperazinyl) phenyl]benzenesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1216468-02-8. Molecular formula: C18H22IN3O3S.HCl. Mole weight: 523.82. | |
| SB 258719 hydrochloride | SB 258719 hydrochloride is a selective 5-HT7 receptor antagonist, displaying > 100-fold selectivity over a range of other receptors. SB 258719 shows inverse action on hypothermic effect of 5-CT in mice following i.p. administration. Synonyms: SB 258719 hydrochloride; SB258719 hydrochloride; SB-258719 hydrochloride; 3-Methyl-N-[(1R)-1-methyl-3-(4-methyl-1-piperidinyl)propyl]-N-methylbenzenesulfonamide hydrochloride; N,3-dimethyl-N-[(2R)-4-(4-methylpiperidin-1-yl)butan-2-yl]benzenesulfonamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1217674-10-6. Molecular formula: C18H30N2O2S.HCl. Mole weight: 374.97. | |
| SB 258741 hydrochloride | SB 258741 hydrochloride is a serotonin 5-HT7 antagonist. Synonyms: SB 258741 hydrochloride; SB-258741 hydrochloride; SB258741 hydrochloride. Grades: 99%. CAS No. 201038-58-6. Molecular formula: C19H30N2O2S.HCl. Mole weight: 386.98. | |
| SB 265610 | SB 265610 is a potent CXCR2 antagonist. Synonyms: SB-265610; SB 265610; SB265610. 1-(2-bromophenyl)-3-(7-cyano-2H-benzotriazol-4-yl)urea; N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea. CAS No. 211096-49-0. Molecular formula: C14H9BrN6O. Mole weight: 357.16. | |
| SB269652 | SB269652, an allosteric modulator of D2R, consists of a tetrahydroisoquinoline pharmacophore bound in the OBS and an indole-2-carboxamide moiety bound in a SBP between TM2 and TM7. SB269652 is the first drug-like allosteric modulator of the dopamine D2 re. Uses: Dopamine d2 receptor antagonists. Synonyms: N-[4-[2-(7-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]-1H-indole-2-carboxamide1H-indole-2-carboxylic acid (4-(2-(cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)cyclohexyl)amideSB269652; SB-269652; SB2 69652; SB269,652; SB-269,652; SB 269,652. CAS No. 215802-15-6. Molecular formula: C27H30N4O. Mole weight: 426.55. | |
| SB-269970 | SB-269970 is a selective 5-HT7 receptor antagonist (pKi of 8.3) with >50-fold selectivity against other receptors, on amphetamine and ketamine-induced hyperactivity and prepulse inhibition (PPI) deficits. Synonyms: 3-[(2R)-2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidin-1-yl]sulfonylphenol3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenolSB 269970; SB269970SB-269970. Grades: >98 %. CAS No. 201038-74-6. Molecular formula: C18H28N2O3S. Mole weight: 352.49. | |
| SB-269970 hydrochloride | SB269970 HCl is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with pKi of 8.3, exhibits >50-fold selectivity against other receptors. Synonyms: SB-269970 hydrochloride; SB 269970 hydrochloride; SB269970 hydrochloride. Grades: >98%. CAS No. 261901-57-9. Molecular formula: C18H28N2O3S.HCl. Mole weight: 388.95. | |
| SB 271046 Hydrochloride | SB 271046 Hydrochloride is the hydrochloride salt form of SB 271046. SB 271046 is an orally-available and selective antagonist of the serotonin (5-hydroxytryptamine or 5-HT) receptor 5-HT6 with at least 100-fold selective for 5-HT6 (pKi = 9.02-8.92) over. Synonyms: 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide Hydrochloride; SB 271046A. CAS No. 209481-24-3. Molecular formula: C20H23Cl2N3O3S2. Mole weight: 488.45. | |
| Sb-277011 | Sb-277011 is a novel, high-anity and selective dopamine D3 receptor antagonist that may have potential in treating the negative symptoms of schizophrenia. pKi: 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively. Synonyms: N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide SB 277011 SB 277011-A SB-277011 SB-277011-A trans-N-(4-(2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)cyclohexyl)-4-quinolinecarboxamide. CAS No. 215803-78-4. Molecular formula: C28H30N4O. Mole weight: 438.56. | |
| SB 297006 | SB 297006 is a potent and selective CCR3 antagonist. Synonyms: 2,2',3,3,3',3'-Hexahydroxy-2,2'-biindan-1,1'-dione; Hydrindantin, anhydrous; 5950-69-6; NSC108697; SB 297006; SB297006; SB-297006; EINECS 227-713-1. CAS No. 58816-69-6. Molecular formula: C18H18N2O5. Mole weight: 342.35. | |
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