BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SR 12813 | SR 12813 is a pregnane X receptor (PXR) agonist (EC50 = 200 and 700 nM for human and rabbit PXR, respectively) that activates the farnesoid X receptor (FXR) at μM concentrations. SR 12813 exhibits hypocholesterolaemic activity via enhancing the degradation of HMG-CoA reductase. Synonyms: SR 12813; SR12813; SR-12813; [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol. Grades: ≥99% by HPLC. CAS No. 126411-39-0. Molecular formula: C24H42O7P2. Mole weight: 504.53. |  |
| SR 13800 | SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM). SR 13800 was shown to inhibit proliferation of Raji lymphoma cells in vitro and suppress lactate uptake in breast cancer cells in vitro. Synonyms: SR13800; SR-13800; SR 13800; 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one; 5-(3-hydroxypropylsulfanyl)-3-methyl-1-(2-methylpropyl)-6-(naphthalen-1-ylmethyl)pyrrolo[3,4-d]pyridazin-4-one. Grades: ≥98% by HPLC. CAS No. 227321-12-2. Molecular formula: C25H29N3O2S. Mole weight: 435.58. | |
| SR 140333 | SR 140333 is a potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). SR 140333 inhibits substance P-invoked calcium mobilization and outward current (IC50 = 1.3 nM), and suppresses NK1-mediated nitric oxide-dependent vasodilation in vivo. Synonyms: SR 140333; SR 140,333; SR 140333A; 1-[2-[(3S)-3-(3,4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride. Grades: ≥97% by HPLC. CAS No. 153050-21-6. Molecular formula: C37H45Cl3N2O2. Mole weight: 656.12. | |
| SR 144528 | SR 144528 is a cannabinoid (CB) receptor 2 inverse agonist with selectivity for CB2 over CB1 receptors. It antagonizes the inhibitory effects of the cannabinoid receptor agonist CP 55,940 on forskolin-stimulated adenylyl cyclase activity in cell lines permanently expressing the h CB2 receptor. It selectively blocks the mitogen-activated protein kinase activity induced by CP 55,940 in cell lines expressing h CB2. Synonyms: SR144528; SR-144528; 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethyl-2-bicyclo[2.2.1]heptanyl]pyrazole-3-carboxamide. Grades: ≥98%. CAS No. 192703-06-3. Molecular formula: C29H34ClN3O. Mole weight: 476.1. | |
| SR 1555 hydrochloride | SR 1555 is an inverse agonist of RORγ with IC50 value of 1 μM. It inhibits endogenous IL-17A gene expression in mouse splenocytes and suppresses differentiation of TH17 cells when cultured under TH17 polarizing conditions. It is effective against various autoimmune diseases. Synonyms: 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone monohydrochloride. Grades: ≥98%. CAS No. 1386439-51-5. Molecular formula: C22H22F6N2O2·HCl. Mole weight: 496.88. | |
| SR 16584 | SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM) with selectivity for α3β4 over α4β2 and α7 subtypes (Ki = 0.508, >100 and >100 μM, respectively). Synonyms: 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one. Grades: ≥98% by HPLC. CAS No. 1150153-86-8. Molecular formula: C17H22N2O. Mole weight: 270.37. | |
| SR 1664 | SR 1664 is a PPARγ (peroxisome proliferator-activated receptor γ ) inhibitor. SR 1664 can block PPARγ by cyclin-dependent kinase 5 with an IC50 value of 80 nM and it does not exhibit agonist activity at the PPARγ receptor. Recent research shows that SR 1664 has anti-diabetic effects in obese mice. Uses: Antidiabetic activity. Synonyms: SR1664; SR-1664; SR 1664. (S)-4'-((2,3-dimethyl-5-((1-(4-nitrophenyl)ethyl)carbamoyl)-1H-indol-1-yl)methyl)-[1,1'-biphenyl]-2-carboxylic acid. Grades: 98%. CAS No. 1338259-05-4. Molecular formula: C33H29N3O5. Mole weight: 547.61. | |
| SR 16832 | SR 16832 is a dual-site covalent antagonist of PPARγ, acting at orthosteric and allosteric sites in the ligand binding domain. It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. Synonyms: 2-Chloro-N-(6-methoxy-4-quinolinyl)-5-nitrobenzamide. Grades: ≥98%. CAS No. 2088135-12-8. Molecular formula: C17H12ClN3O4. Mole weight: 357.75. | |
| SR 17018 | SR 17018 is an orally bioavailable and brain-penetrant agonist of μ-opioid receptors (MOR). Synonyms: 5,6-Dichloro-3-[1-[(4-chlorophenyl)methyl]piperidin-4-yl]-1H-benzimidazol-2-one. Grades: ≥98%. CAS No. 2134602-45-0. Molecular formula: C19H18Cl3N3O. Mole weight: 410.72. | |
| SR 1903 | SR 1903 is an inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and an agonist of liver X receptor (LXR). It also binds to PPARγ without activity. It reduces blood glucose levels in a glucose tolerance test, serum levels of total cholesterol and LDL, body weight, and fat mass in a mouse model of high-fat diet-induced obesity. Synonyms: 1-[2'-Methyl-4'-[[4-(4-pyridylmethyl)-1-piperazinyl]methyl]-4-biphenylyl]-1-(trifluoromethyl)-2,2,2-trifluoroethanol. Grades: ≥98%. CAS No. 1414248-06-8. Molecular formula: C27H27F6N3O. Mole weight: 523.51. | |
| SR 202 | SR 202 is a selective PPARγ antagonist used as an antidiabetic and antiobesity agent. SR 202 inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo, improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. Synonyms: Mifobate; SR 202; SR-202; SR202; (4-Chlorophenyl) (dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester; Mifobate; Clenicor. Grades: ≥99% by HPLC. CAS No. 76541-72-5. Molecular formula: C11H17ClO7P2. Mole weight: 358.65. | |
| SR 2211 | SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). SR 2211 exhibits weak activity at liver X receptor α (LXRα) and has no effect on transcriptional activity of farnesoid X receptors (FXR) or transcriptional activity of ROR&alpha. Synonyms: SR-2211; SR2211;SR 2211; 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol; 1,1,1,3,3,3-hexafluoro-2-[3-fluoro-4-[4-[[4-(pyridin-4-ylmethyl)piperazin-1-yl]methyl]phenyl]phenyl]propan-2-ol. Grades: ≥98% by HPLC. CAS No. 1359164-11-6. Molecular formula: C26H24F7N3O. Mole weight: 527.48. | |
| SR 2595 | SR 2595 is an inverse agonist of PPARγ (IC50 = 30 nM) that represses both transactivation in a promoter:reporter assay and expression of the adipogenic marker fatty acid-binding protein 4 in differentiating murine preadipocytes. Synonyms: 2-[4-[[5-[[(1S)-1-(4-Tert-butylphenyl)ethyl]carbamoyl]-2,3-dimethylindol-1-yl]methyl]phenyl]benzoic acid. Grades: ≥98%. CAS No. 1415252-61-7. Molecular formula: C37H38N2O3. Mole weight: 558.7. | |
| SR 2640 hydrochloride | SR 2640 hydrochloride is a potent and selective competitive leukotriene D4 and E4 receptor antagonist. SR 2640 has been shown to inhibit LTD4- but not histamine-induced guinea pig ileum and trachea contraction (pA2 = 8.7). It also inhibits LTD4-attenuation of human PMN chemotaxis. Synonyms: SR 2640 hydrochloride; SR2640 hydrochloride; SR-2640 hydrochloride; 2-[[3- (2-Quinolinylmethoxy) phenyl]amino]benzoic acid hydrochloride. Grades: ≥99% by HPLC. CAS No. 146662-42-2. Molecular formula: C23H18N2O3.HCl. Mole weight: 406.87. | |
| SR-3306 | SR-3306, an aminopyrimidine derivative, is a JNK Inhibitor and could be mainly active in Phosphorylation & Dephosphorylation actions. Uses: Sr-3306 is a jnk inhibitor and could be mainly active in phosphorylation & dephosphorylation actions. Synonyms: SR-3306; SR-3306; SR-3306. Grades: 98%. CAS No. 1128096-91-2. Molecular formula: C28H26N8O. Mole weight: 490.56. | |
| SR 33805 oxalate | SR 33805 oxalate is a potent Ca2+ channel antagonist that binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM). SR 33805 displays selectivity for vascular smooth muscle, inducing vasorelaxation with no inotropic or chronotropic effects. It exhibits an inhibitory effect on PDGF-stimulated smooth muscle cell proliferation. Synonyms: SR 33805 oxalate; SR33805 oxalate; SR-33805 oxalate; 3, 4-Dimethoxy-N-methyl-N- [3- [4- [ [1-methyl-3- (1-methylethyl) -1H-indol-2-yl] sulfonyl] phenoxy] propyl] benzeneethanamine. Grades: ≥99% by HPLC. CAS No. 121346-33-6. Molecular formula: C32H40N2O5S.C2H2O4. Mole weight: 654.77. | |
| SR 3576 | SR 3576 is a potent and selective JNK3 inhibitor (IC50 = 7 nM) with > 2800-fold selectivity over p38. Synonyms: SR-3576; SR 3576; SR3576; 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)benzamide; JNK3 Inhibitor XII; SR-3576; Aminopyrazole inhibitor, 3576. Grades: ≥97% by HPLC. CAS No. 1164153-22-3. Molecular formula: C27H27N5O5. Mole weight: 501.53. | |
| SR 4370 | SR 4370 is an inhibitor of HDAC. Synonyms: N'-butyl-4-(2,3-difluorophenyl)benzohydrazide. CAS No. 1816294-67-3. Molecular formula: C17H18F2N2O. Mole weight: 304.33. | |
| SR 57227A hydrochloride | SR 57227 hydrochloride is a selective and high affinity 5-HT3 receptor agonist. SR 57227 exhibits anti-depressant like effects and decreases isolation-induced aggressive behavior in rat model. Synonyms: SR 57227A hydrochloride; SR57227A hydrochloride; SR-57227A hydrochloride; 1-(6-Chloro-2-pyridinyl)-4-piperidinamine hydrochloride; 4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride. Grades: ≥99% by HPLC. CAS No. 77145-61-0. Molecular formula: C10H14ClN3.HCl. Mole weight: 248.15. | |
| SR 58611A hydrochloride | SR 58611A hydrochloride is a selective and brain penetrating β3-adrenergic receptor agonist that exhibits anxiolytic and antidepressant effects in rodent models. Uses: Adrenergic beta-3 receptor agonists. Synonyms: SR 58611A hydrochloride; SR58611A hydrochloride; SR-58611A hydrochloride; [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride; Amibegron hydrochloride; Amibegron HCl. Grades: ≥98% by HPLC. CAS No. 121524-09-2. Molecular formula: C22H26ClNO4.HCl. Mole weight: 440.36. | |
| SR 59230A hydrochloride | SR 59230A hydrochloride is a potent, selective and orally available β3 adrenoceptor antagonist (IC50 = 40, 408 and 648 nM for β3, β1 and β2 receptors, respectively). SR 59230A blocks MDMA-induced hyperthermia at low concentrations, while it blocks hyperthermia and also increases heat loss through an α1-AR antagonistic mechanism at high concentrations. Synonyms: SR 59230A hydrochloride; SR59230A hydrochloride; SR-59230A hydrochloride; 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride; (2S)-1-(2-ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino]propan-2-ol hydrochloride. Grades: ≥98% by HPLC. CAS No. 1135278-41-9. Molecular formula: C21H27NO2.HCl. Mole weight: 361.91. | |
| SR-717 lithium | SR-717 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: SR 717 lithium; SR717 lithium. Grades: >98%. CAS No. 2375421-09-1. Molecular formula: C15H8F2LiN5O3. Mole weight: 351.2. | |
| SR 9238 | SR 9238 is a potent and selective LXR inverse agonist (IC50 = 43 and 214 nM for LXRβ and LXRα, respectively) with selectivity over a panel of 20 other nuclear receptors, including FXR. SR 9238 exhibits little activity at peripheral LXR. SR 9238 has been shown to reduce hepatic steatosis in obese mice. Synonyms: SR9238; SR 9238; SR-9238; Ethyl 5-[[[[3'- (Methylsulfonyl) [1, 1'-biphenyl]-4-yl]methyl][ (2, 4, 6-trimethylphenyl) sulfonyl]amino]methyl]-2-furancarboxylate. Grades: ≥98% by HPLC. CAS No. 1416153-62-2. Molecular formula: C31H33NO7S2. Mole weight: 595.73. | |
| SR9243 | SR9243 is a potent and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. Synonyms: SR9243; SR-9243; SR 9243. Grades: 98%. CAS No. 1613028-81-1. Molecular formula: C31H32BrNO4S2. Mole weight: 626.62. | |
| SR 95531 hydrobromide | SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents but exhibits little action on pentobarbitone-induced currents. SR 95531 also acts as a low affinity glycine receptor antagonist. Uses: Gaba antagonists. Synonyms: SR 95531 hydrobromide; SR95531 hydrobromide; SR-95531 hydrobromide; 4-[6-imino-3-(4-methoxyphenyl)pyridazin-1-yl]butanoic acid hydrobromide; 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide; Gabazine hydrobromide. Grades: ≥98% by HPLC. CAS No. 104104-50-9. Molecular formula: C15H17N3O3.HBr. Mole weight: 368.23. | |
| Src I1 | Src I1 is a dual site inhibitor that competes at both the ATP and peptide binding sites of Src tyrosine kinase (IC50 = 44 and 88 nM for Src and Lck, respectively). Src I1 was reported to inhibit VEGFR2 and c-fms at higher concentrations (IC50 = 0.32 and 30 μM, respectively). Synonyms: Src I1; Src I-1; SrcI1. 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; Src Kinase Inhibitor I; Src Inhibitor 1; Src Inhibitor-1. Grades: ≥99% by HPLC. CAS No. 179248-59-0. Molecular formula: C22H19N3O3. Mole weight: 373.4. | |
| SRT1720 | SRT1720 is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body to the known SIRT1 activator resveratrol, but is 1000x more potent. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function. Although SRT1720 is not currently undergoing clinical development, a related compound, SRT2104, is currently in clinical development for metabolic diseases. Synonyms: 2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-; N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide; SRT 1720; SRT-1720. Grades: ≥95%. CAS No. 925434-55-5. Molecular formula: C25H23N7OS. Mole weight: 469.56. | |
| SRT3025 HCl | SRT3025 HCl is the hydrochloride form of SRT3025, an agonist of Sirt1. In Fanconi anemia mice, SRT3025 expands hematopoietic stem and progenitor cells as well as improves hematopoiesis; In Apoe-/- mice, SRT3025 decreases plasma cholesterol, inflammation, atherosclerosis, and also increases hepatic Ldlr expression and Pcsk9 accumulation; SRT3025 suppresses the growth of Panc-1 xenografts. Synonyms: SRT3025 HCl; SRT 3025 HCl; SRT-3025 HCl. Grades: 99.62 %. CAS No. 2070015-26-6. Molecular formula: C31H31N5O2S2.HCl. Mole weight: 606.2. | |
| SRT3109 | SRT3109 is a CXCR2 ligand. Synonyms: SRT3109; SRT-3109; SRT 3109. N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R,2R)-2,3-dihydroxy-1-methylpropyl]amino]-4-pyrimidinyl]-1-azetidinesulfonamide; SCHEMBL3180319; ABP000357; ZINC68197865; CS-0977; RL-00854; HY-15462; DB-061750; KB-298382; CS 0977; RL 00854; HY 15462; DB 061750; KB 298382; CS0977; RL00854; HY15462; DB061750; KB298382. CAS No. 1204707-71-0. Molecular formula: C18H23F2N5O4S2. Mole weight: 475.53. | |
| SRT3190 | SRT3190 is a CXCR2 ligand. Synonyms: SRT3190; SRT-3190; SRT 3190. SCHEMBL3171248; QVKPEMXUBULFBM-FZMZJTMJSA-N ; 4065AH; ZINC95641942; CS-0265; HY-13021; KB-80727; W-5813; CS 0265; HY 13021; KB 80727; W 5813; CS0265; HY13021; KB80727; W5813; N-(2-((2,3-Difluorobenzyl)thio)-6-(((2S,3R)-3,4-dihydroxybutan-2-yl)amino)pyrimidin-4-yl)azetidine-1-sulfonamide. CAS No. 1204707-73-2. Molecular formula: C18H23F2N5O4S2. Mole weight: 475.53. | |
| SSE15206 | SSE15206 is a tubulin polymerization inhibitor that overcomes multidrug resistance. It exhibits potent antiproliferative activities in cancer cell lines. Synonyms: HY-111425; SSE-15206; SSE 15206; 5-Phenyl-3-(3,4,5-trimethoxyphenyl)-3,4-dihydropyrazole-2-carbothioamide. CAS No. 1370046-40-4. Molecular formula: C19H21N3O3S. Mole weight: 371.45. | |
| (S)-SNAP 5114 | (S)-SNAP 5114 is a GABA transport inhibitor, displaying selectivity for GAT-3 and GAT-2 (IC50 = 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1, respectively). (S)-SNAP 5114 was shown to increase thalamic GABA levels, and acts as an anticonvulsant following systemic administration in vivo. Uses: Anticonvulsant. Synonyms: SNAP-5114; SNAP 5114; SNAP5114; (S)-SNAP 5114; 1-[2-[tris(4-methoxyphenyl)methoxy]ethyl]-(S)-3-piperidinecarboxylic acid; (3S) -1-[2-[tris (4-methoxyphenyl) methoxy]ethyl]piperidine-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 157604-55-2. Molecular formula: C30H35NO6. Mole weight: 505.61. | |
| SSR125543 | SSR125543 is a selective corticotropin-releasing factor 1 receptor (CRF1) antagonist with pKi value of 9.08 for native CRF1 receptor. It can prevent stress-induced cognitive deficit associated with hippocampal dysfunction. In Apr 2011, Phase-II for Major depressive disorder was discontinued. Uses: Major depressive disorder. Synonyms: SSR125543; SSR 125543; SSR-125543; SSR 125543A;321839-75-2(hydrochloride);(S)-4-(2-chloro-4-methoxy-5-methylphenyl)-N-(2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl)-5-methyl-N-(prop-2-yn-1-yl)thiazol-2-amine. Grades: 98%. CAS No. 752253-39-7. Molecular formula: C27H28ClFN2OS. Mole weight: 483.04. | |
| SSR 125543A | SSR 125543A is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein. SSR 125543A exhibited antidepressant and anxiolytic properties in the Flinders Sensitive Line rats. Synonyms: SR-125543A; SR125543A; LS-150601; LS150601; LS 150601; 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine hydrochloride. Grades: 98%. CAS No. 321839-75-2. Molecular formula: C27H28ClFN2OS.HCl. Mole weight: 519.5. | |
| SSR128129E | SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment. Synonyms: SSR128129E; SSR 128129E; SSR-128129E. Grades: 0.98. CAS No. 848318-25-2. Molecular formula: C18H15N2NaO4. Mole weight: 346.318. | |
| SSR128129E free acid | SSR128129E free acid is a multi-FGFR blocker with allosteric properties. It inhibits FGFR signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. Synonyms: SSR free acid. Grades: >98%. CAS No. 848463-13-8. Molecular formula: C18H16N2O4. Mole weight: 324.33. | |
| SSR 146977 hydrochloride | SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki = 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor, respectively). SSR 146977 also exhibits an inhibitory effect on senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM). Synonyms: SSR 146977 hydrochloride; SSR146977 hydrochloride; SSR-146977 hydrochloride; N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride. Grades: ≥98% by HPLC. CAS No. 264618-38-4. Molecular formula: C35H42Cl2N4O2.HCl. Mole weight: 658.11. | |
| SSR 149415 | SSR 149415 is a potent and orally available vasopressin V1B antagonist (Ki = 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively), displaying >70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. SSR 149415 has been shown to inhibit stress-induced ACTH release and exhibit anxiolytic-like effects in anxiety models, therefore it is identified as a drug candidate for the treatment of anxiety and depression. Uses: Potential treatment of anxiety and depression. Synonyms: Nelivaptan; SSR149415; SR-149415; SR 149415;; (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 439687-69-1. Molecular formula: C30H32ClN3O8S. Mole weight: 630.11. | |
| SSR 180711 hydrochloride | SSR 180711 hydrochloride is a partial agonist at α7 nAChR. It enhances episodic memory and reverses MK-801-induced deficits in retention of episodic memory. SSR 180711 leads to an increase of extracellular dopamine levels in rat prefrontal cortex and also exhibits antidepressant-like properties. Synonyms: SSR 180711 hydrochloride; SSR180711 hydrochloride; SSR-180711 hydrochloride; 4-Bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate hydrochloride. Grades: ≥98% by HPLC. CAS No. 446031-79-4. Molecular formula: C14H17BrN2O2.HCl. Mole weight: 361.66. | |
| SSR 240612 hydrochloride | SSR 240612 is a bradykinin B1 receptor inhibitor, displaying selectivity for B1 receptor over B2 receptor with Ki values of 0.48-0.73 and 358-481 nM, respectively. Synonyms: SSR 240612; SSR-240612; SSR240612; SSR 240612 HCl. Grades: ≥95%. CAS No. 464930-42-5. Molecular formula: C42H52N4O7S·HCl. Mole weight: 793.41. | |
| SST0116CL1 | SST0116CL1 is a second-generation small molecule inhibitor of Hsp90, which leads to decreased expression of Hsp90 client proteins and reduced tumor cell proliferation and tumor growth. Grades: >98%. CAS No. 1202920-93-1. Molecular formula: C22H30N4O6. Mole weight: 446.50. | |
| ST 148 | ST 148 is a dopamine D2 receptor antagonist. Synonyms: ST148; ST-148; Cortexolone maleate; ST-148; EU-0101046; EU0101046; EU 0101046; (Z)-but-2-enedioic acid;5-(dimethylamino)-N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]naphthalene-1-sulfonamide. Grades: 99%. CAS No. 390803-40-4. Molecular formula: C27H36N4O3S.C4H4O4. Mole weight: 612.74. | |
| ST 1936 oxalate | ST 1936 oxalate is a selective and high affinity agonist of 5-HT6 receptors (Ki = 13, 168, and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively). It also displays moderate affinity for human α2 adrenergic receptors (Ki = 300 nM). ST 1936 oxalate was shown to increase Ca2+ concentration and phosphorylation of Fyn kinase in cloned cells. Synonyms: ST 1936 oxalate; ST1936 oxalate; ST-1936 oxalate; 5-Chloro-3-[2-(dimethylamino)ethyl]-2-methylindole oxalate. Grades: ≥98% by HPLC. CAS No. 1210-81-7. Molecular formula: C13H17ClN2.C2H2O4. Mole weight: 326.78. | |
| ST 198 | ST 198 is a dopamine D3 receptor antagonist. Synonyms: ST 198; ST198; ST-198; KS-00002WSM; DTXSID10694257; N-(4-[1,2,3,4-tetrahydroisoquinolin-2-yl]-butyl)-3-phenylacryl-amide; N-[4-(3,4-Dihydroisoquinolin-2(1H)-yl)butyl]-3-phenylprop-2-enamide. Grades: 99%. CAS No. 854924-64-4. Molecular formula: C22H26N2O. Mole weight: 334.45. | |
| ST247 | ST247 is a selective and inverse peroxisome proliferator-activated receptor (PPAR)β/δ agonist with IC 50 value of 19 nm, 10-fold more potent than GSK0660 with IC50 value of 210 nM. Synonyms: ST247; ST-247; ST 247. methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate. Grades: 98%. CAS No. 1356497-91-0. Molecular formula: C19H26N2O5S2. Mole weight: 426.55. | |
| ST7612AA1 | ST7612AA1 is a potent Histone deacetylase (HDCA) inhibitor. It showed an in vitro activity in the nanomolar range associated with a remarkable in vivo antitumor activity. Uses: Cancer. Synonyms: ST7612AA1; ST 7612AA1; ST7612AA1; S-((S)-7-oxo-6-((R)-5-oxopyrrolidine-2-carboxamido)-7-(phenylamino)heptyl) ethanethioate. Grades: 98%. CAS No. 1428535-92-5. Molecular formula: C20H27N3O4S. Mole weight: 405.51. | |
| ST-836 | ST-836, a dopamine receptor ligand, might have similar effect with dopamine and probably useful as an antiparkinsonian agent. Uses: St-836 is a dopamine receptor ligand and might have similar effect with dopamine and probably useful as an antiparkinsonian agent. Synonyms: ST-836; ST 836; ST836; N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazol-6-amine;ST-836;1148156-63-1;C23H34N4OS;SCHEMBL1193415;4067AH. Grades: 95%. CAS No. 1148156-63-1. Molecular formula: C23H34N4OS. Mole weight: 414.61. | |
| ST-836 hydrochloride | ST-836 hydrochloride, the hydrochloride salt form of verubulin, a dopamine receptor ligand that antiparkinsonian effect. Synonyms: ST836 hydrochloride; ST 836 hydrochloride; N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazol-6-amine;hydrochlorideST-836 (hydrochloride)1415564-68-9C23H34N4OS. ClHDTXSID107353513876AHHY-15238ACS-0920; CS 0920; CS0920W-5910; W 5910; W5910N-(2-(4-(2-Methoxyphenyl)piperazin-1-yl)eth. CAS No. 1415564-68-9. Molecular formula: C23H35ClN4OS. Mole weight: 451.07. | |
| ST 91 | ST 91 is an α2-adrenoceptor agonist that displays ~ 120-fold selectivity for α2 receptors over α1 receptors. It acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. ST 91 exhibits antinociceptive activity and increases tail-flick latencies in Sasco and Harlan rats. Uses: Adrenergic alpha-agonists. Synonyms: ST 91; ST91; ST-91; N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride. Grades: ≥99% by HPLC. CAS No. 4749-61-5. Molecular formula: C13H19N3.HCl. Mole weight: 253.77. | |
| STA-1474 | STA-1474 is a water-soluble prodrug of ganetespib (formerly STA-9090). STA-1474 will metabolize to Ganetespib, which is a potent Hsp90 inhibitor previously shown to kill canine tumor cell lines in vitro and inhibits tumor growth in the setting of murine xenografts. Synonyms: STA-1474; STA 1474; STA1474. Grades: >98%. CAS No. 1118915-78-8. Molecular formula: C20H21N4O6P. Mole weight: 444.38. | |
| Stavudine sodium | Stavudine sodium is a dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. Stavudine sodium is an analog of thymidine. It is phosphorylated by cellular kinases into active triphosphate. Stavudine sodium triphosphate inhibits the HIV reverse transcriptase by competing with natural substrate, thymidine triphosphate. It also causes termination of DNA synthesis by incorporating into it. Mice were treated for 2 weeks with stavudine d4T (500 mg/kg/day), L-carnitine (200 mg/kg/day) or both drugs concomitantly. Body fatness was assessed by dual energy X-ray absorptiometry, and investigations were performed in plasma, liver, muscle and WAT. D4T reduced the gain of body adiposity, WAT leptin, whole body FAO and plasma ketone bodies, and increased liver triglycerides and plasma aminotransferases with mild ultrastructural abnormalities in hepatocytes. Synonyms: Zerit sodium; d4T sodium. Grades: >98%. CAS No. 134624-73-0. Molecular formula: C10H11N2NaO4. Mole weight: 246.2. | |
| Stearoyl ethanolamide | Stearoyl ethanolamide is the ethanolamide of octadecanoic acid and an endocannabinoid neurotransmitter. It exhibits anorexic activity in mice. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: N-(2-Hydroxyethyl)octadecanamide; Stearoylethanolamide; N-stearoylethanolamine; N-(2-Hydroxyethyl)stearamide. Grades: 95%. CAS No. 111-57-9. Molecular formula: C20H41NO2. Mole weight: 327.553. | |
| Stearoyl-L-carnitine chloride | Stearoyl-L-carnitine is a naturally-occurring long-chain acylcarnitine. It inhibits lecithin:cholesterol acyltransferase activity in rat plasma when used at a concentration of 500 μM/ml of plasma. It also inhibits PKC. Synonyms: C18 Carnitine chloride; Octadecanoyl-L-carnitine chloride; R-Stearoyl carnitine chloride. Grades: ≥95%. CAS No. 32350-57-5. Molecular formula: C25H50NO4·Cl. Mole weight: 464.12. | |
| STING agonist-1 | STING agonist-1 (G10) is a novel human-specific STING agonist (IC90 = 24.57 μM), exhibits no direct binding affinity for STING. Uses: Activator of sting-dependent signaling; exhibits no direct binding affinity for sting. Synonyms: G10; G10; G-10; G 10; STING agonist G10;4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide. Grades: ≥98%. CAS No. 702662-50-8. Molecular formula: C21H16ClFN2O3S. Mole weight: 430.88. | |
| STING-agonist-3 | STING-agonist-3 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: (E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benzo[d]imidazole-5-carboxamide. Grades: 99%. CAS No. 2138299-29-1. Molecular formula: C37H42N12O6. Mole weight: 750.8. | |
| STING agonist-3-trihydrochloride | STING agonist-3-trihydrochloride is an agonist of stimulator of interferon genes (STING) for treating cancer. Grades: ≥98%. Molecular formula: C37H45Cl3N12O6. Mole weight: 860.19. | |
| STING-agonist-4 | STING-agonist-4 is an agonist of stimulator of interferon genes (STING) for treating cancer. Synonyms: 1,1'-(butane-1,4-diyl)bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1H-benzimidazole-5-carboxamide}. Grades: 99%. CAS No. 213830-40-8. Molecular formula: C34H38N12O4. Mole weight: 678.74. | |
| STING Agonist-4 | STING agonist-4 is a new type of potent and selective STING agonist, which can induce phosphorylation of IRF3 and IFN-β secretion, and promote the production of IFN-γ inducible protein 10 (IP-10), IL-6 and TNF&alpha. Synonyms: 1,1'-(1,4-Butanediyl)Bis[2-[[(1-Ethyl-3-Methyl-1H-Pyrazol-5-Yl)Carbonyl]Amino]-1H-Benzimidazole-5-Carboxamide; diABZI STING agonist-2. Grades: ≥98% by HPLC. CAS No. 2138300-40-8. Molecular formula: C34H38N12O4. Mole weight: 678.7. | |
| STING Agonist C11 | STING agonist C11 is an agonist of the stimulator of interferon genes (STING) pathway. It activates IFN-dependent signaling and induces secretion of IFN from human cells. Synonyms: N-(Methylcarbamoyl)-2-[[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-phenylacetamide. Grades: ≥95%. CAS No. 875863-22-2. Molecular formula: C19H18N4O3S. Mole weight: 382.44. | |
| STING-IN-2 | STING-IN-2 is a covalent STING inhibitor. Synonyms: N-(4-Butylphenyl)-5-Nitro-2-Furancarboxamide; CBMicro_018692; STING Inhibitor C-170. Grades: 98%. CAS No. 346691-38-1. Molecular formula: C15H16N2O4. Mole weight: 288.3. | |
| STING-IN-3 | STING-IN-3 is an inhibitor of interferon gene stimulator (STING). Synonyms: 2-Furancarboxamide, N-(4-hexylphenyl)-5-nitro-; N-(4-Hexylphenyl)-5-Nitro-2-Furancarboxamide. Grades: 98%. CAS No. 2244881-69-2. Molecular formula: C17H20N2O4. Mole weight: 316.35. | |
| STK393606 | STK393606 is a competitive and selective inhibitor of NAD+-dependent type-I 15-hydroxy PGDH, an enzyme activating PGs via converting the oxidation of primary PGs to their 15-keto metabolites. Synonyms: 2-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-ylsulfanylmethyl)-benzonitrile. Grades: ≥98%. CAS No. 355827-05-3. Molecular formula: C14H9BrN4S. Mole weight: 345.2. | |
| STO-609 | STO-609, a naphthoyl fused benzimidazole cell-permeable compound, is a potent and ATP-competitive inhibitor of the Ca2+/Calmodulin-dependent protein kinase kinase (CaM-KK) (CaM-KKα: Ki = 0.21 μM; CaM-KKβ: Ki = 40 nM). It inhibits CaMKK α and CaMKK β activities, and also suppresses AMP-activated protein kinase phosphorylation via binding to the CaMKK catalytic domain. Synonyms: STO-609; STO 609; STO609; 7-Oxo-7h-Benzimidazo[2,1-A]benz[de]isoquinoline-3-Carboxylic Acid; NCGC00025213-01. Grades: 99.90 %. CAS No. 52029-86-4. Molecular formula: C19H10N2O3. Mole weight: 314.29. | |
| Stressin I | Stressin I is a potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki = 1.5 and 224 nM for CRF1 and CRF2 receptors, respectively). Stressin I inhibits ACTH and cortisol secretion. Synonyms: Cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41). Molecular formula: C203H337N57O56. Mole weight: 4472.24. | |
| SU11274 | SU11274 is a selective Met tyrosine kinase inhibitor with IC50 of 10 nM. Synonyms: SU 11274; SU-11274. Grades: 0.98. CAS No. 658084-23-2. Molecular formula: C28H30ClN5O4S. Mole weight: 568.089. | |
| SU11652 | SU11652 is a cell-permeable and sunitinib-like inhibitor of tyrosine kinase receptor (RTK) and angiogenesis with antineoplastic property. It selectively inhibits PDGFR-β, VEGFR2, FGFR1, FLT3 (IC50 values of 3, 27, 170 and 1.5 nM, respectively) and Kit family members (IC50=~10-500 nM). Synonyms: SU11652; SU 11652; SU-11652. 5-[(Z)-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide. Grades: 99%. CAS No. 326914-10-7. Molecular formula: C22H27ClN4O2. Mole weight: 414.93. | |
| SU14813 | SU14813 is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), KIT, and fms-like tyrosine kinase 3 (FLT-3) (1). SU14813 was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. SU14813 demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice. Synonyms: SU 14813; SU-14813; SU014813; SU-014813; SU 014813. Grades: >98%. CAS No. 627908-92-3. Molecular formula: C23H27FN4O4. Mole weight: 442.491. | |
| SU14813 maleate | SU14813 maleate is an oral, multitargeted tyrosine kinase inhibitor (TKI) targeting vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR), Kit, and fms-like tyrosine kinase 3 (FLT-3). It was developed as a next-generation TKI agent following sunitinib (SU11248) designed to demonstrate optimized pharmacokinetic (PK) and tolerability profiles. It demonstrated broad and potent antitumor activity equivalent to that of sunitinib, which resulted in tumor regression, growth arrest, growth delay, and prolonged survival in established xenograft cancer models in mice. Synonyms: SU14813 maleate; SU 14813 maleate; SU-14813 maleate. Grades: >98%. CAS No. 849643-15-8. Molecular formula: C27H31FN4O8. Mole weight: 558.56. | |
| SU1498 | SU1498 is a selective inhibitor of the receptor tyrosine kinase VEGF receptor 2 (VEGFR2, aka FLK1; IC50 = 700 nM), and inhibits Flk-1 with an IC50 of value of 700 nM. Synonyms: (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]-N-(3-phenylpropyl)prop-2-enamide; SU-1498; SU 1498; SU1498; AG-1498; AG 1498; AG1498; Tyrphostin SU 1498. CAS No. 168835-82-3. Molecular formula: C25H30N2O2. Mole weight: 390.52. | |
| SU6656 | SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. SU6656 was initially identified as a Src kinase inhibitor by virtue of its ability to reverse an effect that an activated mutant form of Src (hu SRC Y530F) has on the actin cytoskeleton, namely the formation of podosome rosettes, otherwise known as invadopodia. Subsequent studies have confirmed that SU6656 is relatively selective for Src family kinases but some additional biochemical activities have been identified including: BRSK2, AMPK, Aurora C, Aurora B, CaMKK&beta. The inhibition of these kinases in biochemical reactions in vitro does not necessarily indicate that these kinases are targets of SU6656 in cells. SU6656 has been used primarily as a research tool to investigate the function of Src family kinases in cellular signal transduction processes and biology. Synonyms: SU 6656; SU-6656. Grades: 0.98. CAS No. 330161-87-0. Molecular formula: C19H21N3O3S. Mole weight: 371.45. | |
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