BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| SU9516 | SU 9516 is a potent, selective cdk2 inhibitor (IC50 values are 0.022, 0.04, >10, >10, 18 and >100 μM for cdk2, cdk1, cdk4, PKC, p38, PDGFR and EGFR respectively). Inhibits pRb phosphorylation causing enhanced pRB/E2F complex formation and induces G1 and G2-M cell cycle arrest. Transcriptionally downregulates Mcl-1 and has antiproliferative, cytostatic and proapoptotic effects in vitro. Synonyms: SU-9516; SU 9516; SU9516. Grades: >98%. CAS No. 377090-84-1. Molecular formula: C13H11N3O2. Mole weight: 241.25. |  |
| Suberohydroxamic acid | SBHA is a histone deacetylase (HDAC) inhibitor (ID50 = 0.25 and 0.3 μM for HDAC1 and HDAC3, respectively). SBHA can be used in combination with cytostatic drugs to enhance their effects against cancer cells. Synonyms: N,N'-dihydroxyoctanediamide. CAS No. 38937-66-5. Molecular formula: C8H16N2O4. Mole weight: 204.22. | |
| Succinylsulfathiazole | Succinylsulfathiazole, a sulfonamide derivative, could restrain the bacteria in the intestine to block the production of folic acid. Uses: Succinylsulfathiazole could restrain the bacteria in the intestine to block the production of folic acid. Synonyms: colistatin; cremosuxidine; kaoxidin; KAOXIDINE; 2-(n(4)-succinylsulfanilamido)thiazole; 2-(N-SUCCINYLSULFANILAMIDO)THIAZOLE. Grades: >97.0%(LC)(T). CAS No. 116-43-8. Molecular formula: C13H13N3O5S2. Mole weight: 355.38. | |
| Sulbentine | Sulbentine is an antifungal. Uses: Sulbentine is an antifungal. Synonyms: Sulbentine; NSC 150555; NSC150555; NSC-150555; 3,5-dibenzyl-1,3,5-thiadiazinane-2-thione;3,5-DIBENZYL-3,4,5,6-TETRAHYDRO-2H-1,3,5-THIADIAZINE-2-THIONE. Grades: ≥98%. CAS No. 350-12-9. Molecular formula: C17H18N2S2. Mole weight: 246.39. | |
| Sulfabrom | Sulfabrom, a long-acting derivative of sulfamezathine, is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle. Synonyms: NSC 5874; SN 3517; NSC5874; SN3517; NSC-5874; SN-3517; 4-amino-N-(5-bromo-4,6-dimethylpyrimidin-2-yl)benzenesulfonamide. CAS No. 116-45-0. Molecular formula: C12H13BrN4O2S. Mole weight: 357.23. | |
| Sulfacetamide Sodium | Sulfacetamide Sodium is an anti-biotic. Uses: Anti-bacterial agents. Grades: >98%. CAS No. 127-56-0. Molecular formula: C8H10N2O3S.Na. Mole weight: 236.22. | |
| Sulfacetamide sodium monohydrate | Sulfacetamide sodium monohydrate is an antibiotic used to treat acne and seborrheic dermatitis. Uses: An antibiotic used for the treatment of skin infections and urinary tract infections. Synonyms: sodium;acetyl-(4-aminophenyl)sulfonylazanide;hydrate; N-[(4-Aminophenyl)sulfonyl]acetamide Monosodium Salt Monohydrate; N-Sulfanilylacetamide Monosodium Salt Monohydrate. Grades: ≥98%. CAS No. 6209-17-2. Molecular formula: C8H9N2NaO3S. Mole weight: 236.22. | |
| Sulfacytine | Sulfacytine, a benzenesulfonamide derivative, could be used as an antibiotic through restraining the formation of folate. Synonyms: CI636; CI-636; CI 636; Sulfacytine; Renoquid; Sulfacitine; Sulfacitinum; 1-Ethyl-N-sulfanilylcytosine; Sulfacitina; 4-amino-N-(1-ethyl-2-oxopyrimidin-4-yl)benzenesulfonamide. Grades: 98%. CAS No. 17784-12-2. Molecular formula: C12H14N4O3S. Mole weight: 294.33. | |
| Sulfameter | Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections. Uses: Leprostatic agents. Synonyms: Sulfamethoxydiazine; SG-75; SG 75; SG75; I-2586; I 2586; I2586; NSC 683528; NSC-683528; NSC683528. Grades: >98%. CAS No. 651-06-9. Molecular formula: C11H12N4O3S. Mole weight: 280.3. | |
| Sulfanilamide | Sulfanilamide is a competitive inhibitor for bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM. Synonyms: F1162; F-1162; F 1162; Sulfanilamide; Gerison; Gombardol. Grades: >98%. CAS No. 63-74-1. Molecular formula: C6H8N2O2S. Mole weight: 172.2. | |
| Sulfanitran | Sulfanitran, a sulfonamide derivative, could be commonly used as an anticoccidial drug for animals. Uses: Sulfanitran could be commonly used as an anticoccidial drug for animals. Synonyms: Sulfanitran; NSC 217299; NSC-217299; NSC217299; ACETYL[P-NITROPHENYL]SULFANILAMIDE; N4-ACETYL-N1-(4-NITROPHENYL)SULFANILAMIDE; SULFANITRAN; sulfanitranapprox.85%; 4-(4-nitrophenylsulfamoyl)acetanilide; sulfanitran approx. 85%;SULFANITRAN VETRANAL (N-(4-ACETYLAMINOBE;sulfanitran85+%. Grades: 96%. CAS No. 122-16-7. Molecular formula: C14H13N3O5S. Mole weight: 335.34. | |
| Sulfaphenazole | Sulfaphenazole is an inhibitor of CYP2C9 (Ki = 0.3 μM) acts as an antibacterial and antimicrobial. Uses: An antibacterial and antimicrobial. Synonyms: Sulfafenazol; BRN-0308518; BRN0308518; BRN 0308518; 4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide. Grades: ≥98%. CAS No. 526-08-9. Molecular formula: C15H14N4O2S. Mole weight: 314.36. | |
| Sulfathiazole | Sulfathiazole is an organosulfur compound that has been used as a short-acting sulfa drug. It can be mainly used for the treatment of digestive tract, respiratory tract infections, mastitis, endometritis and other diseases caused by sensitive bacteria in domestic animals, and it can also be used for toxoplasma infection. Uses: Anti-infective agents. Synonyms: HSDB4380; HSDB-4380; HSDB 4380; Sulfathiazole; Planomide; Poliseptil. Grades: >98%. CAS No. 72-14-0. Molecular formula: C9H9N3O2S2. Mole weight: 255.32. | |
| Sulfatinib | Sulfatinib, an oral drug candidate, is a small molecule inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, and the fibroblast growth factor receptor type 1 (FGFR1). Sulfatinib exhibited an acceptable safety profile and encouraging antitumor activity in patients with advanced solid tumors, particularly neuroendocrine tumors. Synonyms: N-(2-(dimethylamino)ethyl)-1-(3-((4-((2-methyl-1H-indol-5-yl)oxy)pyrimidin-2-yl)amino)phenyl)methanesulfonamide; HMPL012; HMPL012; HMPL 012; Sulfatinib. CAS No. 1308672-74-3. Molecular formula: C24H28N6O3S. Mole weight: 480.58. | |
| Sulfisomidin | Sulfisomidin, closely related to sulfadimidine, is a sulfonamide antibacterial. Synonyms: 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide; Aristamid Augensalbe; Aristamid Augentropfen; Augensalbe, Aristamid; Augentropfen, Aristamid; Elkosin; Sodium, Sulfisomidine; Sulfaisodimidine; Sulfisomidine; Sulfisomidine Sodium; Sulphasomidine. CAS No. 515-64-0. Molecular formula: C12H14N4O2S. Mole weight: 278.33. | |
| Sulfisoxazole | Sulfisoxazole is a sulfonamide antibacterial with an oxazole substituent. Synonyms: NU445; NU-445; NU 445; Sulfisoxazole; Neazolin; Neoxazol. Grades: >98%. CAS No. 127-69-5. Molecular formula: C11H13N3O3S. Mole weight: 267.3. | |
| Suloctidil | Suloctidil is a peripheral vascular dilator previously used for the management of peripheral and cerebrovascular diseases. Suloctidil is a weak, non-selective inhibitor of cyclooxygenase, which can inhibit platelet aggregation. Uses: Na+/k+ atpase inhibitor. Synonyms: Bemperil; Cerebro; Circleton; CP556S; CP 556S; CP-556S; Daufan; Dulai; Hemoantin; MJF 12637; Octamet; Polivasal; Ravenil; Sudil; (1S,2R)-2-(octylamino)-1-(4-propan-2-ylsulfanylphenyl)propan-1-ol; (αS)-4-[(1-Methylethyl)thio]-α-[(1R)-1-(octylamino)ethyl]benzenemethanol; Benzenemethanol, 4-[(1-methylethyl)thio]-α-[1-(octylamino)ethyl]-, (R*,S*)-; (±)-Suloctidil; Dulasi; Dulcotil; Euvasal; Fluversin; Fluvisco; Iangene; Loctidon; Locton; Suloctidyl; Sulocton; Sulodene. Grades: ≥95%. CAS No. 54767-75-8. Molecular formula: C20H35NOS. Mole weight: 337.56. | |
| Sulphadimethoxine | Sulphadimethoxine is a non-reducing glucuronide. Synonyms: NSC 683544; NSC 683544; NSC 683544; Sulfadimethoxine; Madriqid; Madroxin. Grades: >98%. CAS No. 122-11-2. Molecular formula: C12H14N4O4S. Mole weight: 310.33. | |
| Sumanirole maleate | Sumanirole maleate, also referred as PNU 95666E or U95666E, is a high affinity D2 receptor full agonist that shows >200-fold selectivity over dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively) with an ED50 of about 46 nM. Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action. Synonyms: 5,6-dihydro-5-(methylamino)-4H-imidazo(4,5,1ij)-quinolin-2(1H)-one (Z)-2-butenedioate; PNU-95666; PNU95666; PNU 95666; Sumanirole; U 95666E; U-95666E; U95666E. CAS No. 179386-44-8. Molecular formula: C15H17N3O5. Mole weight: 319.31. | |
| SUN-B 8155 | SUN-B 8155 is a non-peptide calcitonin (CT) receptor agonist increasing cAMP production in CHO/hCTR cells (EC50 = 21 μM). SUN-B 8155 has been shown to reduce serum calcium concentrations in vivo following i.p. administration. Synonyms: SUN-B 8155; SUN B 8155; SUNB 8155; SUNB8155; 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone; (3Z)-3-[1-(2-aminoanilino)ethylidene]-1-hydroxy-4-methylpyridine-2,6-dione. CAS No. 345893-91-6. Molecular formula: C14H15N3O3. Mole weight: 273.29. | |
| Sunepitron hydrochloride | Sunepitron hydrochloride is a potent and selective serotonin 5-HT1A autoreceptor agonist, α2-adrenergic antagonist, and dopamine D2 agonist. The phase III clinical trial for the treatment of depression is discontinued. Synonyms: CP-93393-1; 1-[[(7S,9aS)-2-pyrimidin-2-yl-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-7-yl]methyl]pyrrolidine-2,5-dione hydrochloride. Grades: 99%. CAS No. 148408-65-5. Molecular formula: C17H23N5O2.HCl. Mole weight: 365.86. | |
| Supercinnamaldehyde | Supercinnamaldehyde is an activator of the transient receptor potential ankyrin 1 (TRPA1) channel. Uses: Antimutagenic agents. Synonyms: 1-methyl-3-(2-oxopropylidene)indolin-2-one; (3Z)-1-methyl-3-(2-oxopropylidene)indol-2-one. Grades: ≥95%. CAS No. 70351-51-8. Molecular formula: C12H11NO2. Mole weight: 201.2. | |
| Suramin | Suramin, also called as Germanin, has been demonstrated to inhibit a large variety of enzymes including urease, hexokinase, succinic dehydrogenase, p-glucuronidase, acid phosphatase, lysozyme, thrombin, plasma kallikrein, (Na'-K')-activated ATPase, plasmi. Uses: Antineoplastic agents. Synonyms: suramin; Germanin; Naganol; Naphuride; Belganyl; Suramine. Grades: 95%. CAS No. 145-63-1. Molecular formula: C51H40N6O23S6. Mole weight: 1297.29. | |
| Suramin Sodium | The sodium salt of Suramin which is a P2 purinergic antagonist and has been also found to have the effect in blocking the G protein binds to GPCRs so that it was studied the activity against sorts of cancer cell lines. Synonyms: Suramin hexasodium; Suramin sodium salt; Suramine sodium salt; Suramin hexasodium salt. Grades: 98%. CAS No. 129-46-4. Molecular formula: C51H34N6Na6O23S6. Mole weight: 1429.17. | |
| SUVN-502 | SUVN-502 is a 5-HT6 receptor antagonist originated by Suven Life Sciences. It has >1200-fold selectivity over 5-HT2A receptor with a superior profile that differentiates from competitor 5-HT6 antagonists. Phase II clinical trials for the treatment of Alzheimer's disease and Schizophrenia are on-going. Uses: Alzheimer's disease; schizophrenia. Synonyms: SUVN-502; SUVN 502; SUVN502; 1-((2-bromophenyl)sulfonyl)-5-methoxy-3-((4-methylpiperazin-1-yl)methyl)-1H-indole. Grades: 98%. CAS No. 701205-60-9. Molecular formula: C21H24BrN3O3S. Mole weight: 478.41. | |
| SUVN-D4010 | SUVN-D4010 is a selective Serotonin 4 receptor partial agonist originated by Suven Life Sciences. Phase I clinical trials for the treatment of Alzheimer's disease and Schizophrenia are on-going. Uses: Alzheimer's disease; schizophrenia. Synonyms: SUVN-D4010; SUVN-D 4010; SUVN D4010; SUVN-1004028; SUVN-D-1208045; SUVN-D1003019; SUVN-D1104010; SUVN-D1108121;2-(1-isopropyl-1H-indazol-3-yl)-5-(1-(3-methoxypropyl)piperidin-4-yl)-1,3,4-oxadiazole. Grades: 98%. CAS No. 1428862-32-1. Molecular formula: C21H29N5O2. Mole weight: 383.49. | |
| SUVN-G3031 hydrochloride | SUVN-G3031 is a Histamine H3 receptor antagonist originated by Suven Life Sciences. Blockade of Histamine H3 receptor can augment the pre-synaptic release of both histamine and other neurotransmitters including acetylcholine from cholinergic neurons. In Aug 2016, Suven Life Sciences initiated a phase I pharmacokinetics trial for treatment of Cognition disorders in Healthy volunteers in USA. Uses: Cognition disorders. Synonyms: N-[4-(1-cyclobutyl piperidin-4-yloxy)-phenyl]-2-(morpholin-4-yl) acet amide dihydrochloride;1394808-82-2 (free base). Grades: 98%. CAS No. 1394808-20-8. Molecular formula: C21H33Cl2N3O3. Mole weight: 446,41. | |
| SW044248 | SW044248 is a potent and selective Topoisomerase I inhibitor. SW044248 killed approximately 15% of a panel of 74 NSCLC cell lines and was nontoxic to immortalized human bronchial cell lines. Synonyms: SW044248; SW-044248; SW 044248. Grades: 98%. CAS No. 522650-83-5. Molecular formula: C22H23N5O2S. Mole weight: 421.52. | |
| SW203668 trifluoroacetate salt | SW203668 is an irreversible inhibitor of stearoyl-CoA desaturase (IC50 = 54 nM). It is selectively cytotoxic to H2122, H460, HCC44, and HCC95 cell lines. Synonyms: SW203668 TFA; 4-(aminophenylmethyl)-N-(6-methoxy-2-benzothiazolyl)-benzamide trifluoroacetate salt. Grades: ≥98%. CAS No. 2117405-48-6. Molecular formula: C22H19N3O2S·CF3COOH. Mole weight: 503.49. | |
| (S)-WAY 100135 dihydrochloride | (S)-WAY 100135 dihydrochloride is a potent and selective 5-HT1A receptor antagonist (IC50 = 15 nM). Uses: Serotonin antagonists. Synonyms: (S)-WAY 100135 dihydrochloride; (S)-WAY100135 dihydrochloride; (S)-WAY-100135 dihydrochloride; (S)-N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl)-2-phenylpropanamide dihydrochloride. Grades: ≥99% by HPLC. CAS No. 149007-54-5. Molecular formula: C24H33N3O2.2HCl. Mole weight: 468.47. | |
| (S)-Willardiine | The (S)- but not (R)-isomers of willardiine and 5-bromowillardiine were potent agonists, producing rapidly but incompletely desensitizing responses. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50%. In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists. Synonyms: (-)-Willardiine. Grades: >98%. CAS No. 21416-43-3. Molecular formula: C7H9N3O4. Mole weight: 199.16. | |
| SX 011 | SX 011 is a potent p38α inhibitor (IC50 = 9 nM). It also acts as a p38β and JNK-2 inhibitor (IC50 = 90 nM and 100 nM, respectively). SX 011 exhibits no significant activity at p38γ, p38δ, ERK-2 and JNK-1. Synonyms: SX 011; SX011; SX-011; 6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide. Grades: ≥98% by HPLC. CAS No. 309913-42-6. Molecular formula: C26H27ClFN3O3. Mole weight: 483.96. | |
| Syk Inhibitor II | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; 2- ( (2-Aminoethyl) amino) -4- ( (3- (trifluoromethyl) phenyl) amino) pyrimidine-5-carboxamide. Grades: ≥98%. CAS No. 726695-51-8. Molecular formula: C14H15F3N6O. Mole weight: 340.3. | |
| Syk Inhibitor II hydrochloride | Syk inhibitor II is a cell-permeable, ATP-competitive inhibitor of Syk (IC50 = 41 nM). It also exhibits less potent inhibitory effects against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively). Synonyms: Spleen Tyrosine Kinase Inhibitor II; Syk Inhibitor II 2HCl; Syk Inhibitor II dihydrochloride; 2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide dihydrochloride. Grades: ≥98%. CAS No. 227449-73-2. Molecular formula: C14H15F3N6O·2HCl. Mole weight: 413.2. | |
| SYM 2206 | SYM 2206 is a potent and noncompetitive AMPA receptor antagonist (IC50 = 2.8 μM) that exhibits anticonvulsant activity in vivo. SYM 2206 acts allosterically at the same regulatory site as GYKI 52466 and 53655 but does not bind to the central diazepine binding site. Synonyms: SYM2206; SYM 2206; SYM-2206; (±)-4-(4-Aminophenyl)-1,2-dihydro-1-methyl-2-propylcarbamoyl-6,7-methylenedioxyphthalazine; 8-(4-aminophenyl)-5-methyl-N-propyl-5H-[1,3]dioxolo[4,5-g]phthalazine-6-carboxamide. Grades: ≥99% by HPLC. CAS No. 173952-44-8. Molecular formula: C20H22N4O3. Mole weight: 366.42. | |
| Synephrine Hydrochloride | SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist. Synonyms: Synephrine hydrochloride; 5985-28-4; Synephrine HCl; 4-[1-hydroxy-2-(methylamino)ethyl]phenol hydrochloride; 4-(1-Hydroxy-2-(methylamino)ethyl)phenol hydrochloride; Oxedrine hydrochloride; rac-Synephrine Hydrochloride; Synephrine (hydrochloride); MFCD00050566; EN5D1IH09S; 4-[1-hydroxy-2-(methylamino)ethyl]phenol 2,3-dihydroxysuccinate (salt); oxedrine HCl; Synephrine, HCl. Grades: >98%. CAS No. 5985-28-4. Molecular formula: C9H13NO2. Mole weight: 167.21. | |
| Synthalin sulfate | Synthalin sulfate is a noncompetitive NMDA receptor antagonist in vivo and in vitro. Synonyms: Guanidine, N,N'''-1,10-decanediylbis-, sulfate (1:1); N,N'-1,10-Decanediylbisguanidine sulfate; 1,1'-Decamethylenediguanidine sulfate; 1,1'-(decane-1,10-diyl)diguanidine sulfate; 1,10-Diguanidinodecane sulfate. Grades: ≥95%. CAS No. 182285-12-7. Molecular formula: C12H28N6.H2SO4. Mole weight: 354.47. | |
| T0070907 | T0070907 was identified as a potent and selective PPARgamma antagonist. T0070907 blocked PPARgamma function in both cell-based reporter gene and adipocyte differentiation assays. T0070907 is a novel tool for the study of PPARgamma/RXRalpha heterodimer function. Synonyms: T-0070907; T 0070907. Grades: 0.98. CAS No. 313516-66-4. Molecular formula: C12H8ClN3O3. Mole weight: 277.66. | |
| T 0156 hydrochloride | T 0156 hydrochloride is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). T 0156 exhibits higher selectivity than sildenafil (IC50 = 0.23, 56 and > 63000 nM for T 0156 and 3.6, 29 and > 270 nM for sildenafil at PDE5, PDE6 and PDEs 1 - 4 respectively). Synonyms: 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, hydrochloride (1:1); 2,7-Naphthyridine-3-carboxylic acid, 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-, methyl ester, monohydrochloride; Methyl 1,2-dihydro-2-[(2-methyl-4-pyridinyl)methyl]-1-oxo-8-(2-pyrimidinylmethoxy)-4-(3,4,5-trimethoxyphenyl)-2,7-naphthyridine-3-carboxylate hydrochloride (1:1); T0156; T-0156. Grades: ≥99% by HPLC. CAS No. 324572-93-2. Molecular formula: C31H29N5O7.HCl. Mole weight: 620.06. | |
| T-0201 | T-0201 has been found to be an Endothelin A receptor antagonist that could be used as as anti-ischaemic agent and was once studied in heart failure and pulmonary hypertension. Synonyms: T-0201, T0201, T 0201, TA 0201, TA0201, TA-0201; N-(6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-5-(p-tolyl)pyrimidin-4-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide. Grades: 98%. CAS No. 169679-53-2. Molecular formula: C27H28BrN5O5S. Mole weight: 614.52. | |
| T-0201 Sodium | The sodium salt form of T-0201 which has been found to be an Endothelin A receptor antagonist that could be used as as anti-ischaemic agent and was once studied in heart failure and pulmonary hypertension. Synonyms: T-0201 Sodium; T0201 Sodium; T 0201 Sodium; N-(6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-5-(p-tolyl)pyrimidin-4-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide sodium salt. Grades: 98%. CAS No. 188307-16-6. Molecular formula: C27H28BrN5NaO5S+. Mole weight: 637.51. | |
| T-1095 | T-1095, with potential antidiabetic effect, is an inhibitor of renal Na+-glucose cotransporters that may provide a novel way to treating diabetes. Synonyms: [(2R,3S,4S,5R,6S)-6-[2-[3-(1-benzofuran-5-yl)propanoyl]-3-hydroxy-5-methylphenoxy]-3,4,5-trihydroxyoxan-2-yl]methyl methyl carbonate; T 1095; T-1095. Grades: >98%. CAS No. 209746-59-8. Molecular formula: C26H28O11. Mole weight: 516.49. | |
| T16Ainh-A01 | T16Ainh-A01 is a selective inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). T16Ainh-A01 inhibits EGF-induced increases in CaCC currents, and blocks proliferation of pancreatic cancer and squamous carcinoma cells in culture. Synonyms: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide. Grades: ≥98% by HPLC. CAS No. 552309-42-9. Molecular formula: C19H20N4O3S2. Mole weight: 416.52. | |
| T-26c | T-26c is a selective matrix metalloproteinase-13 (MMP-13) inhibitor with IC50 value of 0.0069 nM. It inhibits IL-1β- and oncostatin M-induced collagen degradation in bovine nasal septum cartilage explants by 87.4% when used at a concentration of 0.1 μM. T-26c is used for the treatment of osteroarthritis and rhuematoid arthritis. Synonyms: 4-[[2-[(3-methoxyphenyl)methylcarbamoyl]-4-oxo-3H-thieno[2,3-d]pyrimidin-5-yl]methoxymethyl]benzoic acid. Grades: ≥98%. CAS No. 869296-13-9. Molecular formula: C24H21N3O6S. Mole weight: 479.5. | |
| T 26c disodium salt | T 26c disodium salt is a potent, selective and orally available MMP13 inhibitor (IC50 = 6.9 pM) with >2600-fold selectivity for MMP13 over related MMPs. T 26c inhibits degradation of bovine nasal septum cartilage explants in vitro. Synonyms: Disodium 4-[[[[2-[[[[3- (Methyloxy) phenyl]methyl]amino]carbonyl]-4-oxo-3, 4-dihydrothieno[2, 3-d]pyrimidin-5-yl]methyl]oxy]methyl]benzoate. Grades: ≥98% by HPLC. CAS No. 869298-22-6. Molecular formula: C24H19N3Na2O6S. Mole weight: 523.47. | |
| T338C Src-IN-1 | T338C Src-IN-1, a pyrazolopyrimidine detivative, has been found effective T338C inhibition and could be significant for determing the effect of kinases by Chemical genetics. Uses: T338c src-in-1 has been found effective t338c inhibition and could be significant for determing the effect of kinases by chemical genetics. Synonyms: T338C Src-IN-1; CHEMBL2216823; SCHEMBL7509503; BDBM50403061; HY-16905; HY 16905; HY16905. Grades: 98%. CAS No. 1351926-90-3. Molecular formula: C17H20N6O2S. Mole weight: 372.44. | |
| T338C Src-IN-2 | T338C Src-IN-2, a pyrazolopyrimidine detivative, has been found to be a c-Src T338C kinase inhibitor and could be significant for determing the effect of kinases by Chemical genetics. IC50: 57 nM and 19 nM for T338C and V323S respectively. Uses: T338c src-in-2 has been found to be a c-src t338c kinase inhibitor and could be significant for determing the effect of kinases by chemical genetics. ic50: 57 nm and 19 nm for t338c and v323s respectively. Synonyms: T338C Src-IN-2; SCHEMBL7515000; HY-16906; HY 16906; HY16906. Grades: 98%. CAS No. 1351927-00-8. Molecular formula: C17H18FN5O. Mole weight: 327.36. | |
| TA-02 | TA-02 is a p38 MAPK inhibitor (IC50 = 20 nM). Synonyms: TA-02, TA 02, TA02; SCHEMBL17002317; EX-A933; EX A933; EXA933; MolPort-039-101-302; 4-[2-(2-fluorophenyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyridine. Grades: ≥98%. CAS No. 1784751-19-4. Molecular formula: C20H13F2N3. Mole weight: 333.342. | |
| TACA | TACA, the trans-isomer of CACA, is a potent GABAA and GABAC agonist, GABA uptake inhibitor and substrate for GABA-T. It also acts as a GABAA-ρ agonist. Synonyms: trans-4-Aminocrotonic acid; (E)-4-Amino-2-butenoic acid. CAS No. 38090-53-8. Molecular formula: C4H7NO2. Mole weight: 101.1. | |
| Tacrine hydrochloride | Tacrine hydrochloride is a potent cholinesterase inhibitor used for the treatment of memory deficits in patients with Alzheimers's disease. Tacrine hydrochloride has been shown to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (IC50s = 31 and 26.5 nM, respectively). Tacrine also inhibits the uptake of serotonin and norepinephrine in rat cerebral cortex and reduces depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells. Uses: The treatment of alzheimers's disease. Synonyms: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride; Tacrine HCl; Hydroaminacrine; NSC72108; NSC-72108; NSC72108; Tenakrin. Grades: ≥99% by HPLC. CAS No. 1684-40-8. Molecular formula: C13H14N2.HCl. Mole weight: 234.73. | |
| Tacrine hydrochloride hydrate | Tacrine is a centerally active acetylcholinesterase inhibitor. It has been approved for the treatment of Alzheimer's disease and other central nervous system disorders. Synonyms: Tacrine hydrochloride monohydrate. CAS No. 206658-92-6. Molecular formula: C13H14N2·xHCl·xH2O. Mole weight: 198.26. | |
| TAE-1 | TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation, suggesting its potential for the treatment of Alzheimer's disease. Synonyms: 2-[4-[[4, 6-bis[4-[2- (trimethylazaniumyl) ethoxycarbonyl]phenoxy]-1, 3, 5-triazin-2-yl]oxy]benzoyl]oxyethyl-trimethylazanium triiodide. CAS No. 1414469-59-2. Molecular formula: C39H51N6O9·3I. Mole weight: 1128.6. | |
| TAE226 | TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix. Synonyms: NVPTAE226, NVP TAE226, NVP-TAE226, TAE226, TAE226, TAE 226. Grades: 0.98. CAS No. 761437-28-9. Molecular formula: C23H25ClN6O3. Mole weight: 468.942. | |
| TAE684 | NVP-TAE684 is a highly potent and selective small-molecule ALK inhibitor, which blocked the growth of ALCL-derived and ALK-dependent cell lines with IC(50) values between 2 and 10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest. In vivo, NVP-TAE684 suppressed lymphomagenesis in two independent models of ALK-positive ALCL and induced regression of established Karpas-299 lymphomas. NVP-TAE684 also induced down-regulation of CD30 expression, suggesting that CD30 may be used as a biomarker of therapeutic NPM-ALK kinase activity inhibition. Synonyms: TAE 684, TAE684, TAE-684, NVP-TAE 684, NVP-TAE684, NVP-TAE-684. CAS No. 761439-42-3. Molecular formula: C30H40ClN7O3S. Mole weight: 614.2017. | |
| TAK-044 | Tak-044 has been found to be an endothelin receptor antagonist that was once studied against some sort of liver disorders and subarachnoid haemorrhage. Synonyms: TAK-044, TAK 044, TAK044; CHEMBL61425; AC1L3XH4; Cyclo(D-alpha-aspartyl-3-((4-phenylpiperazin-1-yl)carbonyl)-L-alanyl-L-alpha-aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl) disodium salt; AM017317. Grades: 98%. CAS No. 157380-72-8. Molecular formula: C45H51N9Na2O11S. Mole weight: 971.99. | |
| TAK-063 | TAK-063 is a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. TAK-063 represents a promising drug for the treatment of schizophrenia with potential for superior safety and tolerability profiles. Synonyms: TAK063, TAK 063, TAK-063, Balipodect. Grades: >98%. CAS No. 1238697-26-1. Molecular formula: C23H17FN6O2. Mole weight: 428.42. | |
| TAK-070 | TAK-070, under the IUPAC name 2-Naphthaleneethanamin?e, 6-([1,?1'-biphenyl]?-4-ylmethoxy)?-1,?2,?3,?4-tetrahydro-N,?N-dimethyl-, hydrochloride, hydrate (1:1:1)?, (2R)?-, a novel noncompetitive BACE1 inhibitor, ameliorated Aβ pathology and behavioral deficits in Tg2576. Phase 1. Synonyms: TAK-070; TAK 070; TAK070; 2-Naphthaleneethanamin?e, 6-([1,?1'-biphenyl]?-4-ylmethoxy)?-1,?2,?3,?4-tetrahydro-N,?N-dimethyl-, hydrochloride, hydrate (1:1:1)?, (2R)?-; 2-Naphthaleneethanamine, 6-([1,1'-biphenyl]-4-ylmethoxy)-1,2,3,4-tetrahydro-N,N-dimethyl-, hydrochloride, monohydrate, (2R)- (9CI); UNII-EAC604ZY07; 365276-12-6. CAS No. 365276-12-6. Molecular formula: C27H31NO.HCl.H2O. Mole weight: 440.02. | |
| TAK-071 | TAK-071 is a positive allosteric modulator of muscarinic acetylcholine receptor 1 (M1R). Uses: Muscarinic agonists. Synonyms: TAK-071; 1820812-16-5; UNII-59XC9G796Y; 59XC9G796Y; 4-Fluoro-2-((3S, 4S)-4-hydroxytetrahydro-2H-pyran-3-yl)-5-methyl-6-(4(1H-pyrazol-1-yl)benzyl)-2, 3-dihydro-1H-isoindol-1-one; L-Threo-pentitol, 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-1,3-dihydro-5-methyl-1-oxo-6-((4-(1H-pyrazol-1-yl)phenyl)methyl)-2H-isoindol-2-yl)-; 4-fluoro-2-[(3S,4S)-4-hydroxyoxan-3-yl]-5-methyl-6-[(4-pyrazol-1-ylphenyl)methyl]-3H-isoindol-1-one; 6-(4-(1H-PYRAZOL-1-YL)BENZYL)-4-FLUORO-2-((3S,4S)-4-HYDROXYTETRAHYDRO-2H-PYRAN-3-YL)-5-METHYLISOINDOLIN-1-ONE; CHEMBL4594351; SCHEMBL17201222; GTPL12302; WFSARWQASFQZMG-VXKWHMMOSA-N; AKOS040739717; AC-31580; MS-27399; HY-122190; CS-0082523; D77973; 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-5-methyl-1-oxo-6-(4-(1H-pyrazol-1-yl)benzyl)-1,3-dihydro-2H-isoindol-2-yl)-L-threo-pentitol; 4-fluoro-2-[(3s,4s)-4-hydroxytetrahydro-2h-pyran-3-yl]-5-methyl-6-[4-(1h-pyrazol-1-yl)benzyl]-2,3-dihydro-1h-isoindol-1-one. Grades: 98%. CAS No. 1820812-16-5. Molecular formula: C24H24FN3O3. Mole weight: 421.5. | |
| TAK 21d | TAK 21d is a potent and brain penetrating FAAH inhibitor (IC50 = 0.28 and 0.72 nM at rat and human FAAH, respectively). TAK 21d exhibits analgesic effects in vivo models of neuropathic and inflammatory pain. Synonyms: TAK-21d; TAK 21d; TAK21d; TAK-21-d; 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1143578-94-2. Molecular formula: C19H17F2N7O. Mole weight: 397.38. | |
| TAK-220 | TAK-220 is an orally bioavailable small-molecule CCR5 antagonist. Synonyms: TAK-220, TAK 220, TAK220; 1-acetyl-N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide. Grades: 99.95%. CAS No. 333994-00-6. Molecular formula: C31H41ClN4O3. Mole weight: 553.14. | |
| TAK-259 HCl | This active molecular is a selective α1D Adrenergic Receptor antagonist. ( Ki value of 1.1 nM, 200 fold selective over α1A and 800 fold selective over α1B). TAK-259 exhibited a larger MRTpo value and potent antiurinary frequency efficacy. In Jul 2011, Phase-I clinical trials in Overactive bladder in Japan is on going. In Feb 2013, Phase-I for Overactive bladder in Japan was discontinued. Uses: Overactive bladder. Synonyms: TAK-259, TAK259, TAK259; 5-chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride,1192348-73-4 (free base). Grades: 98%. CAS No. 1192347-42-4. Molecular formula: C14H14Cl3N3O3S. Mole weight: 410.69. | |
| TAK-285 | TAK-285 is a novel dual erbB protein kinase inhibitor that specifically targets human epidermal growth factor receptor (EGFR) and HER2. Methods: TAK-285 is currently being developed by Takeda. TAK-285 was found to be well tolerate in Phase I trials. Absorption of TAK-285 was rapid after oral dosing, and plasma exposure at steady-state increased in a dose-proportional fashion for doses ranging from 50 to 300?mg b.i.d. A partial response was observed for one patient with parotid cancer who received 300?mg b.i.d. The toxicity profile and PK properties of oral TAK-285 warrant further evaluation. Synonyms: TAK285; TAK 285. CAS No. 871026-44-7. Molecular formula: C26H25ClF3N5O3. Mole weight: 547.963. | |
| TAK-593 | TAK-593 is an oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. TAK-593 selectively binds to and inhibits VEGFR and PDGFR, which may result in the inhibition of angiogenesis and tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK593; TAK 593. Grades: >98%. CAS No. 1005780-62-0. Molecular formula: C23H23N7O3. Mole weight: 445.483. | |
| TAK-632 | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50 value of 2.4 nM. Synonyms: TAK632, TAK 632, TAK-632. CAS No. 1228591-30-7. Molecular formula: C27H18F4N4O3S. Mole weight: 554.51. | |
| TAK-659 dihydrochloride | TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. TAK-659 may inhibit the activity of syk, which abrogates downstream BCR (B-cell receptor) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Phase I/II for the treatment Acute myeloid leukaemia, phase I for the treatment of Breast cancer, Gastrointestinal cancer, Head and neck cancer, Lymphoma, Non-small cell lung cancer and Solid tumours was on-going. Uses: Acute myeloid leukaemia;breast cancer; gastrointestinal cancer; head and neck cancer; lymphoma; non-small cell lung cancer; solid tumours most recent events. Synonyms: 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one dihydrochloride; TAK659; TAK-659; TAK 659; TAK-659 HCl; TAK659 dihydrochloride. Grades: 98%. CAS No. 1312691-41-0. Molecular formula: C17H23Cl2FN6O. Mole weight: 417.31. | |
| TAK-659 hydrochloride | TAK-659 hydrochloride is a hydrochloride salt of TAK-659 which is a potent spleen tyrosine kinase (syk) inhibitor (IC50 = 3.2 nM) under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Synonyms: TAK-659 hydrochloride; TAK 659 hydrochloride; TAK659 hydrochloride; 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one;hydrochloride; TAK-659 HCl. CAS No. 1952251-28-3. Molecular formula: C17H22ClFN6O. Mole weight: 380.85. | |
| TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Synonyms: TAK715, TA 715, TAK715. Grades: 0.99. CAS No. 303162-79-0. Molecular formula: C24H21N3OS. Mole weight: 399.512. | |
| TAK-733 | TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK 733; TAK733. Grades: >98%. CAS No. 1035555-63-5. Molecular formula: C17H15F2IN4O4. Mole weight: 504.232. | |
| TAK-779 | TAK-779 is a potent, dual antagonist at chemokine receptors CCR2 and CCR5 with IC50=1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and CXCR4. Synonyms: N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride, TAK-799; TAK 779; TAK779; Takeda 779. Grades: >98%. CAS No. 229005-80-5. Molecular formula: C33H39ClN2O2. Mole weight: 531.13. | |
| TAK-901 | TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK901, TAK-901, TAK 901. Grades: >98%. CAS No. 934541-31-8. Molecular formula: C28H32N4O3S. Mole weight: 504.64. | |
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