BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| TAK-960 | TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. Synonyms: TAK 960; TAK960. CAS No. 1137868-52-0. Molecular formula: C27H34F3N7O3. Mole weight: 561.61. |  |
| TAK-960 dihydrochloride | TAK-960 is an orally available, potent and selective PLK1 inhibitor that was in a phase I clinical trial in patients with advanced non-hematologic malignancies. Synonyms: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;dihydrochloride; TAK-960 (dihydrochloride); TAK 960 (dihydrochloride); TAK960 (dihydrochloride). Molecular formula: C27H36Cl2F3N7O3. Mole weight: 634.52. | |
| TAK-960 hydrochloride | The hydrochloride salt form of TAK-960, a newly studied selective PLK1 inhibitor, might have potential effect in inhibiting proliferation of sorts of cancer cell lines in vitro. The Phase-I was already discontinued for Solid tumours in USA. IC50: 1.5 nM. Uses: The hydrochloride salt form of tak-960 is a newly studied selective plk1 inhibitor and might have potential effect in inhibiting proliferation of sorts of cancer cell lines. Synonyms: TAK-960 (hydrochloride); TAK 960 hydrochloride; TAK960 hydrochloride; HY-15160A; AKOS025147360; 1137868-96-2; 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hyd. Grades: 98%. CAS No. 1137868-96-2. Molecular formula: C27H35ClF3N7O3. Mole weight: 598.06. | |
| Talampanel | Talampanel, also known as LY300164 and GYKI-53773, is a glutamate receptor inhibitor with anti-seizure activity. Talampanel is also an orally active, potent and selective AMPA-receptor antagonist, and can noncompetitively bind to the AMPA subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury. Talampanel (GYKI 53405) is being investigated for the treatment of epilepsy, malignant gliomas and amyotrophic lateral sclerosis (ALS). As of May 2010, results from the trial for ALS have been found negative. Synonyms: LY300164; LY 300164; LY-300164; GYKI-53773; Gyki 53405; Gyki53405; Gyki-53405; LY293606; LY-293606; LY 293606. Grades: >98%. CAS No. 161832-65-1. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| TALIPEXOLE | Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor which has better ameliorative rate of symptom than bromocriptine and might be effctive in the treatment of Parkinson's disease. Uses: Talipexole (b-ht920) is a highly selective agonist of d2 receptor and α2-adrenoceptor. Synonyms: TALIPEXOLE;5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine;Domin;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;Talipexol;Talipexol [spanish];Talipexolum. Grades: 95%. CAS No. 101626-70-4. Molecular formula: C10H15N3S. Mole weight: 209.31. | |
| Talmapimod hydrochloride | Talmapimod, also known as SCIO-469, is an orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins. Synonyms: SCIO 469 hydrochloride; SCIO469 hydrochloride; SCIO-469 hydrochloride. Grades: >98%. CAS No. 309913-83-5. Molecular formula: C27H30ClFN4O3. Mole weight: 513.01. | |
| Talnetant hydrochloride | Talnetant is the hydrochloride salt of Talnetant. Talnetant, also called as SB 223412, is a selective, competitive, nonpeptide NK3 receptor antagonist and is in development for the treatment of the positive symptoms of schizophrenia. It exhibits 100-fold. Synonyms: 3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;hydrochloride Talnetant HCl Talnetant (hydrochloride) UNII-C1ZIJ8F59E Talnetant hydrochloride Talnetant hydrochloride (USAN) Talnetant hydrochloride [USAN] 204519-66-4 SCHEMBL5154081 CHEMBL. CAS No. 204519-66-4. Molecular formula: C25H23ClN2O2. Mole weight: 418.92. | |
| Talniflumate | Talniflumate is a calcium-activated chloride channel (CaCC) (hCLCA1/mCLCA3) blocker. It decreases mucin synthesis and release in cell culture and animal models. Talniflumate inhibits cyclooxygenases and Cl-/HCO3- exchanger activity to produce anti-inflammatory actions. Talniflumate also increases survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. Uses: Anti-inflammatory agent. Synonyms: 2-[[3-(Trifluoromethyl)phenyl]amino]-1,3-dihydro-3-oxo-1-isobenzofuranyl 3-pyridinecarboxylic acid ester; Somalgen; Lomucin; (3-oxo-1H-2-benzofuran-1-yl) 2-[3-(trifluoromethyl)anilino]pyridine-3-carboxylate. Grades: ≥99% by HPLC. CAS No. 66898-62-2. Molecular formula: C21H13F3N2O4. Mole weight: 414.34. | |
| TAMOLARIZINE | Tamolarizin is a calcium antagonist originated by Nippon Chemiphar. Tamolarizin can induce the increase of GABA in the cerebellum and medulla oblongata following continuous administration in animal models. It also have a mild behavior-facilitating effect. Treatment for Neurological disorders was discontinued. Uses: Neurological disorders. Synonyms: NC-1100; NC 1100; NC1100; UNII-0PG3PMK9YA;2-(4-benzhydrylpiperazin-1-yl)-1-(3,4-dimethoxyphenyl)ethan-1-ol. Grades: 98%. CAS No. 128229-52-7. Molecular formula: C27H32N2O3. Mole weight: 432.56. | |
| Tanaproget | Tanaproget is a novel nonsteroidal progesterone receptor agonist that is first in its class and has high affinity and selectivity for the progesterone receptor. Preclinical research shows that tanaproget has greater potency than reference steroidal proges. Synonyms: NSP-989, NSP989, NSP 989, Tanaproget; 5-(4,4-dimethyl-2-sulfanylidene-1H-3,1-benzoxazin-6-yl)-1-methylpyrrole-2-carbonitriletanaproget. CAS No. 304853-42-7. Molecular formula: C16H15N3OS. Mole weight: 297.37. | |
| Tandutinib | Tandutinib, also known as MLN 518, is a piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis. Synonyms: MLN0518, MLN 518, MLN-518, MLN518, NSC726292, NSC 726292, NSC-726292, CT53518, CT-53518, CT 53518, D06005, D-06005, D 06005, Tandutinib. Grades: >98%. CAS No. 387867-13-2. Molecular formula: C31H42N6O4. Mole weight: 562.715. | |
| Tanzisertib hydrochloride | The hydrochloride of Tanzisertib. Tanzisertib (CC-930) is a potent and selective JNK inhibitor which is potentially used for prevention and treatment of dermal fibrosis. Tanzisertib exhibits a potent antifibrotic activity thus might to treat fibrosis in SSc. Synonyms: CC-930 hydrochloride; CC 930 hydrochloride; CC930 hydrochloride. Grades: 99.04 %. Molecular formula: C21H23F3N6O2.HCl. Mole weight: 484.9. | |
| TAPI 0 | TAPI 0 is an ADAM-17 (TACE) and matrix metalloprotease (MMP) inhibitor. TAPI 0 can inhibit spontaneous and PMA-induced TNF α release and processing. Synonyms: N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide; KD-IX 73-4; TAPI; TNF-a Protease Inhibitor 0; TAPI 0; TAPI0; TAPI-0. Grades: ≥95% by HPLC. CAS No. 163958-73-4. Molecular formula: C24H32N4O5. Mole weight: 456.54. | |
| TAPI-2 | TAPI-2 is a broad-spectrum inhibitor of TNF-α converting enzyme (TACE; ADAM17), other ADAMs and matrix metalloproteinases (MMPs). It inhibits phorbol-12-myristate-13-acetate-induced (PMA) shedding of various cell surface proteins, such as TGF-α, β amyloid precursor protein, L-selectin, and IL-6 receptor α subunit. Synonyms: TNF Protease Inhibitor 2; N-[(2S)-1-[[(2S)-1-(2-Aminoethylamino)-1-oxopropan-2-yl]amino]-3,3-dimethyl-1-oxobutan-2-yl]-N'-hydroxy-2-(2-methylpropyl)butanediamide. Grades: ≥95%. CAS No. 187034-31-7. Molecular formula: C19H37N5O5. Mole weight: 415.5. | |
| Tarafenacin | Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. Synonyms: SVT-40776, SVT 40776, SVT40776, Tarafenacin. Grades: >98%. CAS No. 385367-47-5. Molecular formula: C21H20F4N2O2. Mole weight: 408.39. | |
| Tarafenacin D-tartrate | Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki=0.19 nM), ~200 fold selectivity over M2 receptor. Synonyms: SVT-40776; SVT 40776; SVT40776; Tarafenacin (D-tartrate); Tarafenacin D-tartrate; Tarafenacin D tartrate; Tarafenacin Dtartrate; Tarafenacin-D-tartrate. Grades: >98%. CAS No. 1159101-48-0. Molecular formula: C25H26F4N2O8. Mole weight: 558.48. | |
| Taranabant | Taranabant is a cannabinoid 1 receptor inverse agonist ( IC50 =0.3 nM). Uses: A cannabinoid 1 receptor inverse agonist. Synonyms: MK-0364, MK 0364, MK0364, Taranabant. N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide;N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide. Grades: ≥95%. CAS No. 701977-09-5. Molecular formula: C27H25ClF3N3O2. Mole weight: 515.95. | |
| Tarloxotinib bromide | Tarloxotinib bromide, a pyridopyrimidine derivative, has been found to be a EGFR tyrosine kinase inhibitor precursor and could probably be effective in antineoplastic researches. Synonyms: Tarloxotinib bromide; Tarloxotinib bromide [INN]; SCHEMBL11902818; SCHEMBL17873943; [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium;bromide. Grades: 98%. CAS No. 1636180-98-7. Molecular formula: C24H24Br2ClN9O3. Mole weight: 681.77. | |
| TAS-103 | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. TAS-103 may be useful in the chemotherapy of colorectal cancer. Uses: Topoisomerase i inhibitors. Synonyms: BMS-247615; TAS103; TAS 103; BMS247615; BMS 247615. Grades:>98%. CAS No. 174634-08-3. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| TAS-103 dihydrochloride | TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. Synonyms: 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride; TAS103; TAS-103; TAS 103; BMS247615; BMS 247615; BMS-247615. Grades:>98%. CAS No. 174634-09-4. Molecular formula: C20H21Cl2N3O2. Mole weight: 406.31. | |
| TAS-115 | This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. Uses: Solid tumours. Synonyms: TAS-115; TAS 115; TAS115; 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide. Grades: 98%. CAS No. 1190836-34-0. Molecular formula: C27H23FN4O4S. Mole weight: 518.56. | |
| TAS-116 | TAS-116 is a inhibitor of Hsp90. It induces significant cytotoxicity in MM cells even in the presence of BMSCs, associates with downregulation of phospho-Akt and phospho-ERK. In addition, neither exogenous IL-6 nor IGF-1 was able to protect against TAS-116. Importantly, TAS-116 did not induce cytotoxicity in BMSCs. TAS-116 enhanced bortezomib-induced cytotoxicity in MM.1S and RPMI-8226 cells, associated with decreased phospho-Akt, phospho-RelA (p65), phospho-IkBa, and phospho-IKKα/β; as well as increased CHOP and PARP cleavage. These results suggest that TAS-116 blocks bortezomib-induced canonical NF-κB pathway and augments bortezomib-induced endoplasmic reticulum (ER) stress. Synonyms: TAS116; TAS 116; TAS-116; 3-Ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide. Grades: >98%. CAS No. 1260533-36-5. Molecular formula: C25H26N8O. Mole weight: 454.54. | |
| TAS-301 | TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits smooth muscle cell migration and proliferation. Synonyms: TAS-301; TAS301; TAS301. Grades: 98%. CAS No. 193620-69-8. Molecular formula: C23H19NO3. Mole weight: 357.41. | |
| TAS6417 | TAS6417 is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. TAS6417 inhibited EGFR phosphorylation and downstream molecules in NSCLC cell lines expressing EGFR exon 20 insertions, resulting in caspase activation. Synonyms: CLN-081; TPC-064; TAS 6417; TAS-6417; Zipalertinib. CAS No. 1661854-97-2. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
| Taselisib | Taselisib, also known as GDC0032 or RG7606, is a selective, potent, orally bioavailable inhibitor of PI3Ka with a Ki = 0.2nM, and with reduced inhibitory activity against PI3K. This selectivity profile, and excellent pharmacokinetic and pharmaceutical properties, allowed for greater efficacy in vivo at the maximum tolerated dose relative to a pan Class I PI3K inhibitor in PIK3CA mutant xenografts. Notably, GDC-0032 preferentially inhibited PIK3CA mutant cells relative to cells with wild-type PI3K. GDC-0032 potently inhibits signal transduction downstream of PI3K and induces apoptosis at low concentrations in breast cancer cell lines and xenograft models that harbor PIK3CA mutations. Synonyms: GDC-0032; GDC0032; GDC 0032; RG7604; RG-7604; RG 7604; Taselisib. CAS No. 1282512-48-4. Molecular formula: C24H28N8O2. Mole weight: 460.542. | |
| Tasosartan | Tasosartan, a pyrido-pyrimidin derivative, has been found to be an angiotensin II receptor antagonist that could have probable effect against hypertension. It has been discontinued for some security problems by Wyeth. Synonyms: TASOSARTAN;2,4-Dimethyl-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[6,5-d]pyrimidin-7-one. Grades: 98%. CAS No. 145733-36-4. Molecular formula: C23H21N7O. Mole weight: 411.46. | |
| TASP 0390325 | TASP 0390325 is a potent and selective vasopressin V1B receptor antagonist (IC50 = 2.22 nM for rat pituitary receptor) with no significant affinity for 85 other receptors, ion channels and transporters at 10 μM, including V1A and V2. TASP 0390325 increases ACTH levels in rats. TASP 0390325 has the potential use as antidepressant and anxiolytic. Synonyms: TASP0390325, TASP 0390325, TASP-0390325; 2-(3-Chloro-4-fluorophenyl)-N-(1-methylethyl)-6-[3-(4-morpholinyl)propoxy]-4-oxo-pyrido[2,3-d]pyrimidine-3(4H)-acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1642187-96-9. Molecular formula: C25H29ClFN5O4.HCl. Mole weight: 554.44. | |
| TASP 0433864 | TASP 0433864 is a selective and positive allosteric modulator of mGlu2 receptor (EC50 = 199 and 206 nM for human and rat receptors, respectively) with no agonist activity at rat mGlu2 receptors. It displays weak activity against a range of neurotransmitter targets except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Synonyms: TASP0433864, TASP0433864, TASP0433864; (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide. Grades: ≥98% by HPLC. CAS No. 1431980-60-7. Molecular formula: C18H23N3O3. Mole weight: 329.39. | |
| Tasquinimod | Tasquinimod is a quinoline-3-carboxamide linomide analogue with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blood vessel density but the exact mechanism of action is not known. This agent has also been shown to augment the antineoplastic effects of docetaxel and androgen ablation in a murine model of prostate cancer involving human prostate cancer xenografts. Uses: For research used only. Synonyms: ABR215050, ABR-215050, ABR 215050, Tasquinimod. Grades: 0.98. CAS No. 254964-60-8. Molecular formula: C20H17F3N2O4. Mole weight: 406.361. | |
| Tauro-α-muricholic acid sodium salt | Tauro-α-muricholic acid is an antagonist of the farnesoid X receptor (FXR) with IC50 value of 28 μM. Synonyms: 5β-cholanic acid-3α,6β,7α-triol N-(2-sulphoethyl)-amide, sodium salt; Taro-α-muricholate; TαMCA; 2-[[(3α, 5β, 6β, 7α)-3, 6, 7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. Grades: ≥95%. CAS No. 2260905-08-4. Molecular formula: C26H44NNaO7S. Mole weight: 537.69. | |
| Tauro-β-muricholic acid sodium salt | Tauro-β-muricholic acid is a competitive and reversible antagonist of the farnesoid X receptor (FXR) with IC50 value of 40 μM. Synonyms: 5beta-cholanic acid-3alpha,6beta,7beta-triol N-(2-sulphoethyl)-amide, sodium salt; 2-[[(3alpha,5beta,6beta,7beta)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt. Grades: ≥95%. CAS No. 145022-92-0. Molecular formula: C26H44NNaO7S. Mole weight: 537.69. | |
| Tavilermide | Tavilermide is a selective, small-molecule partial agonist of TrkA, or a nerve growth factor (NGF) mimetic. Synonyms: 3-[(5S,8S,11S)-8-(4-aminobutyl)-5-(carboxymethylcarbamoyl)-16-nitro-7,10,13-trioxo-2-oxa-6,9,12-triazabicyclo[12.4.0]octadeca-1(14),15,17-trien-11-yl]propanoic acid. Grades: >98%. CAS No. 263251-78-1. Molecular formula: C24H32N6O11. Mole weight: 580.55. | |
| TB 21007 | TB 21007, as a nootropic drug, is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Synonyms: 3-(2-hydroxyethylsulfanyl)-6,6-dimethyl-1-(1,3-thiazol-2-yl)-5,7-dihydro-2-benzothiophen-4-one; CHEMBL17603207306-50-1; TB-21007, TB 21007, TB21007. Grades: >98%. CAS No. 207306-50-1. Molecular formula: C15H17NO2S3. Mole weight: 339.5. | |
| TBPB | TBPB is an allosteric M1 mAChR agonist that regulates amyloid processing and produces antipsychotic-like activity in rats. Synonyms: TBPB; 634616-95-8; 1-(1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; CHEMBL522460; 3-[1-[1-[(2-methylphenyl)methyl]piperidin-4-yl]piperidin-4-yl]-1H-benzimidazol-2-one; 2-Pyrrolo-1,3,2-dioxa-phospholan; GTPL3258; SCHEMBL5473311; CWPKTBMRVATCBL-UHFFFAOYSA-N; BCP13406; TBPB, >=98% (HPLC); BDBM50263887; AKOS026750197; 2-pyrrol-1-yl-1,3,2-dioxaphospholan; CS-3517; NCGC00390669-01; HY-14562; MS-26922; FT-0746315; F85081; A918055; BRD-K86989957-001-01-7; Q27088942; 1,3-Dihydro-1-[1'-[(2-methylphenyl)methyl][1,4'-bipiperidin]-4-yl]-2H-benzimidazol-2-one; 1-(1''-(2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1''-2-methylbenzyl)-1,4''-bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-(1a?(2-Methylbenzyl)-1,4a?bipiperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-[1-[1-(2-Methylbenzyl)piperidin-4-yl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one. Grades: >98%. CAS No. 634616-95-8. Molecular formula: C25H32N4O. Mole weight: 404.55. | |
| TC 1 | TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), serotonin (SERT), noradrenalin (NET) transporters (Ki > 10 μM) and dopamine D2 receptors (Ki = 1226 nM). Synonyms: TC 1; TC1; TC-1; (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02, 6.03, 10.05, 9.08, 11]dodecan-3-ol. Grades: ≥99% by HPLC. CAS No. 362512-81-0. Molecular formula: C19H20FNO. Mole weight: 297.37. | |
| TC 1698 dihydrochloride | TC 1698 dihydrochloride is a selective nicotinic α7 receptor agonist (EC50 = 440 nM) displaying neuroprotective activity. TC 1698 dihydrochloride also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Synonyms: TC 1698 dihydrochloride; TC1698 dihydrochloride; TC-1698 dihydrochloride; 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]nonane dihydrochloride. Grades: ≥98% by HPLC. CAS No. 787587-06-8. Molecular formula: C13H18N2.2HCl. Mole weight: 275.22. | |
| TC 2559 difumarate | TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 = 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes, respectively). TC 2559 difumarate has the selectivity for (α4)2(β2)3 receptor stoichiometry and can enhance CNS-PNS selectivity ratio. Synonyms: TC 2559 difumarate; TC2559 difumarate; TC-2559 difumarate; 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate. Grades: ≥98% by HPLC. CAS No. 212332-35-9. Molecular formula: C12H18N2O.2C4H4O4. Mole weight: 438.43. | |
| TC-A 2317 hydrochloride | TC-A 2317 hydrochloride is a selective and potent Aurora kinase A (ARK-1) inhibitor (Ki = 1.2 nM and 101 nM for inhibition of Aurora kinase A and Aurora kinase B, respectively) with selectivity over 60 other kinases (IC50 > 1000 nM). TC-A 2317 exhibits great cell permeability and antitumor activity. Synonyms: TC-A2317 HCl; TC-A2317 Hydrochloride; TCA2317 HCl; TC A2317 HCl; TC A2317 Hydrochloride; TCA2317 Hydrochloride; TC-A-2317 hydrochloride; 2-[(5-Hydroxy-1,5-dimethylhexyl)amino]-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile hydrochloride. Grades: ≥98% by HPLC. CAS No. 1245907-03-2. Molecular formula: C19H28N6O.HCl. Mole weight: 392.93. | |
| TC AC 28 | TC AC 28 is a high affinity BET bromodomain ligand (Kd = 40 and 800 nM for Brd2(2) and Brd2(1), respectively) with 20-fold selectively for the second over the first bromodomain. Synonyms: TC-AC28, TC AC28, TCAC28; 6-(1H-Indol-4-yl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetic acid methyl ester. Grades: ≥98% by HPLC. CAS No. 1809296-92-1. Molecular formula: C23H21N5O3. Mole weight: 415.44. | |
| TC AQP1 1 | TC AQP1 1 is an aquaporin 1 (AQP1) channel blocker (IC50 = 8 μM). TC AQP1 1 was shown to suppress water flux in Xenopus oocytes. Synonyms: TC-AQP1-1; 3,3'-(1,3-Phenylene)bis(2-propenoic acid); CBMicro_016818; M-phenylenediacrylic acid; M-phenylene diacrylic acid. Grades: ≥98% by HPLC. CAS No. 37710-81-9. Molecular formula: C12H10O4. Mole weight: 218.211. | |
| TCB-2 | TCB-2 is a high affinity 5-HT2A receptor agonist (Ki = 0.73 and 0.75 nM for rat and human receptors, respectively). TCB-2 stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors (EC50 = 36 nM). It also induces head twitches and hypothermia in mice following i.p. adminitration. Synonyms: TCB 2; TCB2; (4-Bromo-3,6-dimethoxybenzocyclobuten-1-yl)methylamine hydrobromide; Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, 3-bromo-2,5-dimethoxy-, hydrobromide (1:1); Bicyclo[4.2.0]octa-1,3,5-triene-7-methanamine, 3-bromo-2,5-dimethoxy-, monohydrobromide; (3-bromo-2,5-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methanamine hydrobromide. Grades: ≥99% by HPLC. CAS No. 912342-28-0. Molecular formula: C11H14BrNO2.HBr. Mole weight: 353.05. | |
| TC-C 14G | TC-C 14G is a potent and high affinity cannabinoid-1 (CB1) receptor inverse agonist (EC50 = 11 nM in cAMP assay; Ki = 4 nM). Synonyms: [2-(2,4-Dichlorophenyl)-6-fluoro-2-(4-fluorophenyl)-1,3-benzodioxol-5-yl]-4-morpholinyl-methanone. Grades: ≥98% by HPLC. CAS No. 656804-72-7. Molecular formula: C24H17Cl2F2NO4. Mole weight: 492.3. | |
| TC-E 5002 | TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 = 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A, respectively) with antitumor activity. It suppresses growth of HeLa and KYSE-150 cancer cells in vitro. Synonyms: TC-E 5002; TC E 5002; TCE 5002; TCE-5002; TCE5002; TC-E-5002; N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine. Grades: ≥98% by HPLC. CAS No. 1453071-47-0. Molecular formula: C15H27NO4. Mole weight: 285.38. | |
| TC-E 5005 | TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 = 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively, and >5000 nM at PDE1B, 4A, 6, 8A and 9A). TC-E 5005 reverses MK 801-induced hyperactivity and stereotypy in vivo. It also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate. Synonyms: TC-E 5005; TC E-5005; TC E 5005; TC-E-5005; TCE5005; 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine. Grades: ≥99% by HPLC. CAS No. 959705-64-7. Molecular formula: C15H18N4O. Mole weight: 270.33. | |
| TC-E 5006 | TC-E 5006, also called BIIB042, is a potent γ-secretase modulator, which lowered Aβ42, increased Aβ38, but had little to no effect on Aβ40 levels both in vitro and in vivo. In addition, it did not affect Notch signaling in our in vitro assessment. Aβ42: EC50 = 0.17 μM. Synonyms: TC-E 5006; TCE 5006; TC E 5006; TC-E-5006; TCE5006; 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid; BIIB042. CAS No. 1257395-14-4. Molecular formula: C29H29F4NO2. Mole weight: 499.54. | |
| TC-E 5008 | TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
| TC-F 2 | TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively). Synonyms: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥99% by HPLC. CAS No. 1304778-15-1. Molecular formula: C26H25N5O2. Mole weight: 439.51. | |
| TC-G 1000 | TC-G 1000 is a potent and orally bioactive α2D-adrenoceptor agonist (Ki = 8.6 pM and 110 nM for rat α2D and α1 receptors respectively, and 25, 26 and 100 nM for human α2A, α2C and α2B receptors respectively). TC-G 1000 displays analgesic activity in a mouse model of abdominal irritation. Synonyms: TC-G 1000; TC G 1000; TCG 1000; TCG1000; 4-(6,7-Dihydro-1,3-dimethylbenzo[c]thien-4-yl)-1H-imidazole maleate. Grades: ≥98% by HPLC. CAS No. 245744-18-7. Molecular formula: C13H14N2S.C4H4O4. Mole weight: 346.4. | |
| TC-G 1003 | TC-G 1003 is a potent and high affinity somatostatin sst2 receptor agonist (Ki = 0.025 nM). TC-G 1003 exhibits an inhibitory effect on growth hormone secretion and attenuates laser-induced ocular neovascular lesion size in rats. Synonyms: TC-G1003; TC G1003; TCG1003; 3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]phenol. Grades: ≥98% by HPLC. CAS No. 1021912-42-4. Molecular formula: C26H25ClN2O2. Mole weight: 432.94. | |
| TC-G 1004 | TC-G 1004 is a potent and selective A2A antagonist. Synonyms: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide. CAS No. 1061747-72-5. Molecular formula: C22H27N7O2. Mole weight: 421.5. | |
| TC-G 24 | TC-G 24 is a potent and brain penetrating GSK-3β inhibitor (IC50 = 17 nM) with selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). TC-G 24 has been shown to increase liver glycogen reserves in rodents. Synonyms: TC-G 24; TC G 24; TCG 24; TCG-24; TCG24; N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine. Grades: ≥98% by HPLC. CAS No. 1257256-44-2. Molecular formula: C15H11ClN4O3. Mole weight: 330.73. | |
| TC-H 106 | TC-H 106 is a slow, tight-binding inhibitor of class I HDAC, including HDAC 1, 2, and 3 with IC50 values of 150 nM , 760nM, and 370 nM, respectively. It demonstrats no activity against class II HDACs. It inhibits these enzymes through different mechanisms. It also has preference toward HDAC3 with K(I) of approximately 14 nm, 15 times lower than the K(I) for HDAC1. It exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM. It progressively binds HDACs and remains bound after wash-out. It may have therapeutic value in Friedrich's ataxia and Huntington's disease due to their low animal toxicity. Uses: Tc-h 106 may have therapeutic value in friedrich's ataxia and huntington's disease. Synonyms: TC-H 106, TC-H106, TC-H-106, TCH-106, TCH 106, TCH106, Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106;N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide;N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide;RGFA-8;Histone Deacetylase Inhibitor VII. Grades: >99 %. CAS No. 937039-45-7. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| TC-I 15 | TC-I 15 is a potent α2β1 integrin inhibitor (IC50 = 12 and 715 nM for the inhibition of human platelet adhesion to type I collagen and for platelets under static conditions and under flow, respectively), displaying selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 was shown to reduce collagen IV production in mesangial cells. Synonyms: TC-I 15; TCI 15; TC I 15; TCI15; N-[[ (4R)-5, 5-Dimethyl-3- (phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[ (phenylmethyl)amino]carbonyl]amino]-L-alanine. Grades: ≥98% by HPLC. CAS No. 916734-43-5. Molecular formula: C23H28N4O6S2. Mole weight: 520.62. | |
| TC-I 2000 | TC-I 2000 is a potent and orally bioactive TRPM8 channel blocker. TC-I 2000 was shown to inhibit icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM). Synonyms: TC-I2000; TC I 2000; TCI 2000; TCI2000; N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide; 2(1H)-Isoquinolinecarboxamide, N-(4-fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethyl-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-fluoro-phenyl)-amide. Grades: ≥99% by HPLC. CAS No. 1159996-20-9. Molecular formula: C23H18F4N2O. Mole weight: 414.40. | |
| TC-I 2014 | TC-I 2014 is a potent TRPM8 antagonist (IC50 = 0.8, 3.0 and 4.4 nM for canine, human and rat channels, respectively) displaying antiallodynic properties in vivo. Synonyms: TC-I 2014; TC I 2014; TCI 2014; 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene. Grades: ≥98% by HPLC. CAS No. 1221349-53-6. Molecular formula: C23H19F6N3O. Mole weight: 467.41. | |
| TC KHNS 11 | TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor with preference for PI 3-Kδ over a panel of lipid and protein kinases. Synonyms: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 1431540-99-6. Molecular formula: C28H24N6O3. Mole weight: 492.53. | |
| TC-N 1752 | TC-N 1752 is a state-dependent human NaV channel inhibitor (IC50 = 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9, respectively). TC-N 1752 inhibits Nav1.7 and exhibits analgesic efficacy in the formalin pain model. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. Synonyms: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide; Nav1.7 blocker 52. Grades: ≥99% by HPLC. CAS No. 1211866-85-1. Molecular formula: C25H27F3N6O3. Mole weight: 516.52. | |
| TCN 201 | TCN 201 is an NMDA receptor antagonist with selectivity for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 = 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays). Synonyms: TCN-201, TCN 201, TCN201; 3-Chloro-4-fluoro-N- [4- [ [2- (phenylcarbonyl) hydrazino] carbonyl] benzyl] benzenesulfonamide; QCR-22. Grades: ≥99% by HPLC. CAS No. 852918-02-6. Molecular formula: C21H17ClFN3O4S. Mole weight: 461.89. | |
| TCN 213 | TCN 213 is an NMDA receptor antagonist with selectivity for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B. Synonyms: TCN 213; TCN213; TCN-213; N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide. Grades: ≥99% by HPLC. CAS No. 556803-08-8. Molecular formula: C18H24N4OS2. Mole weight: 376.54. | |
| TC-N 22A | TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells) with selectivity over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 > 10 μM). TC-N 22A is used for the treatment of Parkinson's disease, anxiety and pain. Uses: The treatment of parkinson's disease, anxiety and pain. Synonyms: 4, 5, 6, 8-Tetrahydro-N-2-pyridinylpyrazolo[3', 4':6, 7]cyclohepta[1, 2]thiazol-2-amine; N-pyridin-2-yl-4, 5, 6, 7-tetrahydropyrazolo[2, 3]cyclohepta[2, 4-b][1, 3]thiazol-2-amine. Grades: ≥98% by HPLC. CAS No. 1314140-00-5. Molecular formula: C14H13N5S. Mole weight: 283.35. | |
| TCN 237 dihydrochloride | TCN 237 dihydrochloride is a potent and NR2B-selective NMDA antagonist (Ki = 0.8 nM), blocks NR2B-mediated calcium influx in Ltk cells (Ki = 9.7 nM). Uses: Highly potent nr2b-selective nmda receptor antagonist. Synonyms: NMDA-IN-1; TCN 237 dihydrochloride; TCN237 dihydrochloride; TCN-237 dihydrochloride; 2-[[4-[(2-Fluorophenyl)methyl]-1-piperidinyl]methyl]-1H-benzimidazol-6-ol dihydrochloride. Grades: ≥98%. CAS No. 700878-19-9. Molecular formula: C20H24Cl2FN3O. Mole weight: 412.33. | |
| TCN238 | TCN238 is an orally available, brain penetrant and positive allosteric mGlu4 receptor modulator (EC50 = 1 μM) with 30-fold selectivity over mGluR5 using human recombinant receptors in CHO-K1 cells. Synonyms: Lu AF32615; Lu AF-32615; Lu AF 32615; Lu-AF32615; LuAF32615; TCN-238; TCN 238; TCN238; 4-[(E)-2-phenylethenyl]pyrimidin-2-amine. CAS No. 125404-04-8. Molecular formula: C12H11N3. Mole weight: 197.24. | |
| TC NTR1 17 | TC NTR1 17 is a non-peptide neurotensin receptor 1 (NTS1) partial agonist (EC50 < 15.6 nM and Emax = 63% of neurotensin response in Ca2+ mobilization assay). TC NTR1 17 displays over 50-fold selectivity for NTS1 over NTS2 and GPR35. Synonyms: N-[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]-L-leucine; (2S)-2-[[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl]amino]-4-methylpentanoic acid. Grades: ≥99% by HPLC. CAS No. 1146757-96-1. Molecular formula: C27H27ClN4O5. Mole weight: 522.98. | |
| TC OT 39 | TC OT 39 is a potent non-peptide oxytocin receptor partial agonist (EC50 = 33 nM and 850 nM for the oxytocin receptor and V2 vasopressin receptor, respectively). TC OT 39 is also a V1a vasopressin receptor antagonist (Ki = 330 nM). Synonyms: TC-OT 39, TC OT 39, TCOT 39; (2S)-N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-2-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)thioxomethyl]-1-pyrrolidinecarboxamide. Grades: ≥97% by HPLC. CAS No. 479232-57-0. Molecular formula: C32H40N8O2S. Mole weight: 600.78. | |
| TC-P 262 | TC-P 262 is a selective P2X3 and P2X2/3 receptor antagonist (pIC50 = 7.39 and 6.68, respectively). TC-P 262 has no detectable activity at P2X1, P2X2, P2X4 and P2X7 receptors (pIC50 < 4.7). Synonyms: 5-[5-Methyl-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine. Grades: ≥99% by HPLC. CAS No. 873398-67-5. Molecular formula: C14H18N4O. Mole weight: 258.32. | |
| TCS 1102 | TCS 1102 is a potent, dual orexin receptor antagonist with Ki values of 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycoprotein, which demonstrates good brain penetration when administered intraperitoneally. It were found to decrease fear and anxiety in rats 14 days after exposure to footshock. It was also found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. Uses: Tcs 1102 was found to have anxiolytic effects. Synonyms: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)-;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide;TCS 1102, TCS1102, TCS-1102;(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide. Grades: >98 %. CAS No. 916141-36-1. Molecular formula: C27H26N4O2S. Mole weight: 470.59. | |
| TCS 1105 | TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand that acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki = 118 and 245 nM, respectively). Synonyms: TCS 1105; TCS1105; TCS-1105; N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide. Grades: ≥99% by HPLC. CAS No. 185391-33-7. Molecular formula: C17H13FN2O2. Mole weight: 296.3. | |
| TCS 1205 | TCS 1205 is a GABAA α2 benzodiazepine receptor agonist and GABAA α1 partial agonist in vitro (Ki = 14 and 121 nM, respectively). It displays non-sedative anxiolytic activity in vivo. Synonyms: TCS 1205; TCS1205; TCS-1205; 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide; 2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide. Grades: ≥99% by HPLC. CAS No. 355022-97-8. Molecular formula: C18H15N3O4. Mole weight: 337.33. | |
| TCS 183 | TCS 183 is a fragment 1-13 of human and mouse GSK-3β sequence. TCS 183 is potentially used as a competitive inhibitor of GSK-3β (Ser9) phosphorylation. Synonyms: TCS 183; TCS183; TCS-183. Molecular formula: C58H96N20O20S. Mole weight: 1425.58. | |
| TCS 184 | TCS 184 is a scrambled control peptide for use with TCS 183. Synonyms: TCS 184; TCS184; TCS-184. CAS No. 1315378-71-2. Molecular formula: C58H96N20O20S. Mole weight: 1425.58. | |
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