BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Thioproperazine | Thioproperazine is a potent neuroleptic with antipsychotic properties, for the treatment of all types of acute and chronic schizophrenia, including those which did not respond to the usual neuroleptics; manic syndromes. Uses: Antipsychotic. Synonyms: Sulfenazin; N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide. Grades: ≥98%. CAS No. 316-81-4. Molecular formula: C22H30N4O2S2. Mole weight: 446.63. |  |
| Thonzonium bromide | Thonzonium Bromide is an inhibitor of ATP-dependent as a monocationic detergent. Uses: Surface active agent and inhibitor of v-atpase proton transport. Synonyms: hexadecyl-[2-[(4-methoxyphenyl)methyl-pyrimidin-2-ylamino]ethyl]-dimethylazanium;bromide. Grades: ≥98%. CAS No. 553-08-2. Molecular formula: C32H55BrN4O. Mole weight: 591.71. | |
| threo Ifenprodil hemitartrate | Threo Ifenprodil hemitartrate is the hemitartrate salt of threo ifenprodil, which is a NR2B subunit-selective NMDA receptor antagonist, as well as a potent σ receptor agonist. It inhibits the hERG potassium channel and shows antiarrhythmic activity in vivo. It also can be used for the treatment of Alzheimer's disease in combination with AMPA inhibitors. Synonyms: (1S*,2S*)-threo-2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol Hemitartrate; (αR,βR)-rel- α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidineethanol (2R,3R)-2,3-Dihydroxybutanedioate (2:1). CAS No. 1312991-83-5. Molecular formula: C23H30NO5. Mole weight: 400.49. | |
| THS-044 | THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings. Uses: Regulating hif2 activity in endogenous and clinical settings. Synonyms: THS-044; THS 044; THS044; N-[2-Nitro-4-(trifluoromethyl)phenyl]-4-morpholinamine;N-Morpholino-2-nitro-4-(trifluoromethyl)aniline. Grades: ≥95%. CAS No. 62054-67-5. Molecular formula: C11H12F3N3O3. Mole weight: 291.23. | |
| THZ1-R | THZ1-R, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor but has instability in vivo. Synonyms: N-[3-[[5-chloro-4- (1H-indol-3-yl) pyrimidin-2-yl]amino]phenyl]-4-[4- (dimethylamino) butanoylamino]benzamideTHZ1-R. CAS No. 1621523-07-6. Molecular formula: C31H30ClN7O2. Mole weight: 568.07. | |
| THZ2 | THZ2, an analog of THZ1, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo. IC50: CDK7= 13.9 nM; TNBC cells= 10 nM. Synonyms: N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamideTHZ2; THZ 2; THZ-2.1604810-84-5. CAS No. 1604810-84-5. Molecular formula: C31H28ClN7O2. Mole weight: 566.05. | |
| THZ531 | THZ531 is an inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. THZ531 inhibits proliferation of Jurkat cells with IC50 value of 50 nM and induces apoptosis in a concentration-dependent manner. THZ531 causes a loss of gene expression with concurrent loss of elongating and hyperphosphorylated RNA polymerase II. Synonyms: (E)-N-[4-[(3R)-3-[[5-Chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidine-1-carbonyl]phenyl]-4-(dimethylamino)but-2-enamide. Grades: ≥95%. CAS No. 1702809-17-3. Molecular formula: C30H32ClN7O2. Mole weight: 558.07. | |
| Tiapride hydrochloride | Tiapride is a D2 and D3 dopamine receptor antagonist used to treat a variety of neurological and psychiatric disorders. Uses: D2 and d3 dopamine receptor antagonist. Synonyms: N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide; hydrochloride; N-[2-(Diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-benzamide Hydrochloride. Grades: ≥98%. CAS No. 51012-33-0. Molecular formula: C15H25ClN2O4S. Mole weight: 364.88. | |
| TIC10 | TIC10 inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improved pharmacokinetics. Synonyms: ONC201; ONC 201; ONC-201; NSC 350625; NSC350625; NSC-350625; TIC10; TIC 10; TIC-10. Grades: >98%. CAS No. 41276-02-2. Molecular formula: C24H26N4O. Mole weight: 386.49. | |
| Tifenazoxide | Tifenazoxide is a potent selective KATP channels opener with preference for Kir6.2/SUR1. Studies show that it inhibits glucose stimulated insulin release in vitro and in vivo, and has beneficial effect on glucose homeostasis. Synonyms: Tifenazoxide; NN 414; NN-414; NN414; 6-chloro-N-(1-methylcyclopropyl)-1,1-dioxo-4H-thieno[3,2-e][1,2,4]thiadiazin-3-amine. Grades: 99%. CAS No. 279215-43-9. Molecular formula: C9H10ClN3O2S2. Mole weight: 291.78. | |
| Tigecycline hydrochloride | Tigecycline is active against a broad range of gram-negative and gram-positive bacterial species including clinically important multidrug-resistant nosocomial and community-acquired bacterial pathogens. Tigecycline has been shown to inhibit the translation elongation step by binding to the ribosome 30S subunit and preventing aminoacylated tRNAs to accommodate in the ribosomal A site. Tigecycline has also been found to be effective for the treatment of community- as well as hospital-acquired and ventilator-associated pneumonia and bacteremia, sepsis with shock and urinary tract infections. Tigecycline appears to be a valuable treatment option for the management of superbugs, especially where conventional therapy has failed. Synonyms: GAR-936; GAR 936; GAR936; Tygacil. Grades: >98%. CAS No. 197654-04-9. Molecular formula: C29H40ClN5O8. Mole weight: 622.11. | |
| Tigecycline mesylate | Tigecycline mesylate a first-in-class, broad spectrum antibiotic with activity against antibiotic-resistant organisms. Synonyms: Tigecycline mesylate; 1135871-27-0; Tigecycline (mesylate); (4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide; methanesulfonic acid; GAR-936 mesylate; HY-B0117B; AKOS030526271; CS-1878. Grades: >98%. CAS No. 1135871-27-0. Molecular formula: C30H43N5O11S. Mole weight: 681.75. | |
| Tigemonam | Tigemonam, also known as SQ 30836, a monobactam, inhibited 90% of strains tested of Escherichia coli, Klebsiella spp., Proteus spp., Salmonella spp., Haemophilus influenzae and Branhamella catarrhalis at concentrations of 0.25 mg/l or below. Synonyms: 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(3S)-2,2-dimethyl-4-oxo-1-sulfooxyazetidin-3-yl]amino]-2-oxoethylidene]amino]oxyacetic acid; SQ 30836; SQ-30836; tigemonam. CAS No. 102507-71-1. Molecular formula: C12H15N5O9S2. Mole weight: 437.41. | |
| Tilbroquinol | Tilbroquinol is an antiprotozoal agent effective against amoebiasis. It has been used against Vibrio cholerae. Grades: >98%. CAS No. 7175-9-9. Molecular formula: C10H8BrNO. Mole weight: 238.08. | |
| Tilfrinib | Tilfrinib, a pyridoindol derivative, has been found to be a breast tumor kinase (Brk) inhibitor that could probably restrain the proliferation of breast cancer cells. IC50: 3.15 nM. Synonyms: CHEMBL3133821; MolPort-042-624-535; BDBM50001733; AKOS027470214; 3-(1H-Pyrido[2,3-b]indole-4-ylamino)phenol; Tilfrinib|3-(9H-Pyrido[2,3-b]indol-4-ylamino)phenol. Grades: 98%. CAS No. 1600515-49-8. Molecular formula: C17H13N3O. Mole weight: 275.31. | |
| Timcodar | Timcodar, a pyridine derivative, has been found to be a p-glycoprotein inhibitor as well as nerve growth factor stimulant and was once studied in the treatment of bacterial infection and some sorts of cancers. Synonyms: Timcodar; UNII-U141W322WZ; VX853; VX853; VX 853; (2S) -N-benzyl-3- (4-chlorophenyl) -N- (1, 5-dipyridin-4-ylpentan-3-yl) -2-[methyl-[2-oxo-2- (3, 4, 5-trimethoxyphenyl) acetyl]amino]propanamide. Grades: 98%. CAS No. 179033-51-3. Molecular formula: C43H45ClN4O6. Mole weight: 749.29. | |
| Timtraxanib | Timtraxanib is an angiogenesis inhibitor. Synonyms: timtraxanibum. Grades: >98%. CAS No. 2412172-33-7. Molecular formula: C28H43N7O9. Mole weight: 621.31. | |
| Tin protoporphyrin IX dichloride | Tin protoporphyrin IX dichloride is a potent heme oxygenase inhibitor with selectivity for HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 μM). Tin protoporphyrin IX dichloride is used for the prevention of hyperbilirubinemia in neonates. Synonyms: (OC-6-13)-Dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-N21,N22,N23,N24]-stannate(2-) Dihydrogen. CAS No. 14325-05-4. Molecular formula: C34H32Cl2N4O4Sn. Mole weight: 750.25. | |
| Tioconazole | Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast, with an average IC50 of 1.7 μM. Synonyms: UK20,349; UK-20,349; UK 20,349; STS 557; STS557; STS-557. Grades: >98%. CAS No. 65899-73-2. Molecular formula: C16H13Cl3N2OS. Mole weight: 387.71. | |
| Tiotidine | Tiotidine is a potent histamine H2 receptor antagonist with negligible activity against H1- and H3- receptors. Synonyms: 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine. Grades: ≥99% by HPLC. CAS No. 69014-14-8. Molecular formula: C10H16N8S2. Mole weight: 312.41. | |
| Tipifarnib | Tipifarnib is a nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction. By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. Uses: Antineoplastic agents. Synonyms: R115777; R 115777; R-115777; LX81; NSC702818; D03720; Tipifarnib; trade name Zarnestra. Grades: 0.97. CAS No. 192185-72-1. Molecular formula: C27H22Cl2N4O. Mole weight: 489.4. | |
| Tipifarnib S enantiomer | Tipifarnib S enantiomer is the S enantiomer of Tipifarnib. Tipifarnib, also called as Zarnestra or R115777, is a farnesyltransferase inhibitor (IC50= 0.6 nM) with antitumor activity. Synonyms: 6-[(S)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one Tipifarnib (S enantiomer) CHEMBL243659 tipifarnib zarnestra (S)-TIPIFARNIB tipifarnib(r115777) SCHEMBL4429738 (r)-(+)-r 115777 FT-0675247 tipifarnib(zar. CAS No. 192185-71-0. Molecular formula: C27H22Cl2N4O. Mole weight: 489.40. | |
| Tiprolisant | Tiprolisant is potent and selective nonimidazole inverse agonist at the histamine H3 receptor. (Ki=0.16 nM). Uses: The histamine h3 receptor. Synonyms: Pitolisant; 1-[3-[3- (4-chlorophenyl) propoxy]propyl]piperidine. Grades: ≥95%. CAS No. 362665-56-3. Molecular formula: C17H26ClNO. Mole weight: 295.85. | |
| TIQ-A | TIQ-A is a PARP1 inhibitor with IC50 value of 450 nM. It exhibits neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 μM). Uses: Poly(adp-ribose) polymerase inhibitors. Synonyms: 4H-Thieno[2,3-c]isoquinolin-5-one; Thieno[2,3-c]isoquinolin-5(4H)-one; 4H,5H-thieno[2,3-c]isoquinolin-5-one. Grades: ≥98%. CAS No. 420849-22-5. Molecular formula: C11H7NOS. Mole weight: 201.2. | |
| tislelizumab | Tislelizumab is a humanized monoclonal antibody (MAb) that targets PD-1 to prevent it binding to PD-L1 and PD-L2. Tislelizumab is developed for the treatment of solid tumor. Uses: Potential treatment of solid tumor. Synonyms: BGB-A317; BGB A317; BGBA317. CAS No. 1858168-59-8. | |
| Tivantinib | Tivantinib (ARQ-197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing consitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. Synonyms: ARQ-197; ARQ 197; ARQ197; Tivantinib. CAS No. 905854-02-6. Molecular formula: C23H19N3O2. Mole weight: 369.424. | |
| Tivozanib hydrate | Tivozanib is an orally available VEGFR inhibitor with IC50 values of 0.21, 0.16, and 0.24 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. It has been improved for the treatment of renal cell carcinoma. It also displays activity against other cancers. Synonyms: VEGFR Tyrosine Kinase Inhibitor IV; AV-951; KRN 951; 1-[2-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxyphenyl]-3-(5-methyl-1,2-oxazol-3-yl)urea hydrate. Grades: ≥95%. CAS No. 682745-40-0. Molecular formula: C22H19ClN4O5·H2O. Mole weight: 472.9. | |
| Tizanidine | Tizanidine, a short-acting drug, is an agonist at a2-adrenergic receptor reducing spasticity by increasing presynaptic inhibition of motor neurons. Uses: An agonist at a2-adrenergic receptor. Synonyms: 4-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-8-thia-7,9-diazabicyclo(4.3.0)nona-2,4,6,9-tetraen-5-amine; 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine. Grades: ≥98%. CAS No. 51322-75-9. Molecular formula: C9H8ClN5S. Mole weight: 253.71. | |
| TJN-331 | TJN-331 is a TGF-β1 inhibitor, which can inhibit the expression of TGF-β1 and improve anti-glomerular basement membrane nephritis. Synonyms: TJN331; TJN 331. CAS No. 219964-53-1. Molecular formula: C19H22N2O3. Mole weight: 326.4. | |
| TL 102 hydrobromide | TL 102 hydrobromide is a dopamine receptor agonist. Synonyms: 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalene-1,2-diol hydrobromide; TL 102 HBr; TL102 HBr; TL-102 HBr. Grades: 98%. CAS No. 62421-54-9. Molecular formula: C16H25NO2.HBr. Mole weight: 344.29. | |
| TL 13-110 | TL 13-110 is an ALK inhibitor with IC50 value of 0.34 nM. It acts as a negative control for TL 13-112. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -5-isopropoxy-2-methylphenyl) piperidin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229037-09-4. Molecular formula: C49H62ClN9O9S. Mole weight: 988.59. | |
| TL 13-22 | TL 13-22 is an ALK inhibitor with IC50 value of 0.54 nM. It acts as a negative control for TL 13-22. Synonyms: N- (2- (2- (2- (4- (4- ( (5-Chloro-4- ( (2- (isopropylsulfonyl) phenyl) amino) pyrimidin-2-yl) amino) -3-methoxyphenyl) piperazin-1-yl) ethoxy) ethoxy) ethyl) -2- ( (1, 3-dioxo-2- (2-oxopiperidin-3-yl) isoindolin-4-yl) amino) acetamide. Grades: ≥98% by HPLC. CAS No. 2229036-65-9. Molecular formula: C45H55ClN10O9S. Mole weight: 947.5. | |
| TL 232 hydrobromide | TL 232 hydrobromide is a dopamine receptor agonist. Synonyms: 6-(dipropylamino)-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide; TL 232 hydrobromide; TL-232 hydrobromide; TL232 hydrobromide; Dipropyl-6,7-ADTN HBr. Grades: 98%. CAS No. 62421-17-4. Molecular formula: C16H25NO2.HBr. Mole weight: 344.29. | |
| TL4-12 | TL4-12 is a potent MAP4K2 (GCK) inhibitor with IC50 value of 37 nM, suppressing IL-1 and TGFβ-induced p38 MAPK phosphorylation in vitro. Synonyms: 4-Methyl-3-[[6-(methylamino)-4-pyrimidinyl]oxy]-N-[3-(4-methyl-1-piperazinyl)-5-(trifluoromethyl)phenyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1620820-12-3. Molecular formula: C25H27F3N6O2. Mole weight: 500.53. | |
| TL8-506 | TL8-506 is a benzoazepine compound as an agonist of TLR8 agonist. Synonyms: Ethyl 2-amino-8-(3-cyanophenyl)-3H-benzo[b]azepine-4-carboxylate; 3H-1-Benzazepine-4-carboxylic acid, 2-amino-8-(3-cyanophenyl)-, ethyl ester; TL 8-506; TLR 8-506. Grades: ≥95%. CAS No. 1268163-15-0. Molecular formula: C20H17N3O2. Mole weight: 331.37. | |
| TL 99 hydrobromide | TL 99 hydrobromide is a putative dopamine autoreceptor agonist. Synonyms: TL 99 hydrobromide; TL99 hydrobromide; TL-99 hydrobromide; 6-(dimethylamino)-5,6,7,8-tetrahydronaphthalene-2,3-diol hydrobromide; TL 99 HBr. Grades: 98%. CAS No. 62421-56-1. Molecular formula: C12H17NO2.HBr. Mole weight: 288.18. | |
| TM-38837 | TM-38837 is a peripheral selective cannabinoid receptor 1 (CB1) receptor antagonist. Synonyms: TM38837; TM 38837; 1- (2, 4-Dichlorophenyl) -4-ethyl-N- (piperidin-1-yl) -5- (5- ( (4- (trifluoromethyl) phenyl) ethynyl) thiophen-2-yl) -1H-pyrazole-3-carboxamide; N-Piperidino-1-(2,4-dichlorophenyl)-4-ethyl-5-[5-[4-(trifluoromethyl)phenylethynyl]-2-thienyl]-1H-pyrazole-3-carboxamide. Grades: ≥ 95 %. CAS No. 1253641-65-4. Molecular formula: C30H25Cl2F3N4OS. Mole weight: 617.51. | |
| TMB 8 hydrochloride | TMB 8 is a PKC inhibitor and intracellular calcium antagonist. It also acts as a noncompetitive, functional antagonist at diverse nicotinic acetylcholine receptor (nAChR) subtypes. Synonyms: 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate;hydrochloride. Grades: ≥ 98 %. CAS No. 53464-72-5. Molecular formula: C22H38ClNO5. Mole weight: 431.99. | |
| TMC353121 | TMC353121 is a potent RSV fusion inhibitor. Its activity profile was found to be identical to the profile of JNJ-2408068. Synonyms: TMC-353121; TMC 353121; TMC353121. Grades: >98%. CAS No. 857066-90-1. Molecular formula: C32H42N6O3. Mole weight: 558.71. | |
| TMI 005 | TMI 005, also known as Apratastat, is a matrix metalloproteinase/tumour necrosis factor-α convertase (MMP/TACE) inhibitor for the treatment of rheumatoid arthritis. It inhibits secretion of soluble TNF-α and downregulates multiple MMPs, which is involved in cartilage destruction and bone erosions of RA. Uses: The treatment of rheumatoid arthritis. Synonyms: TMI-005; TMI005; TMI 005; XMT-1191; XMT 1191; XMT1191. Apratastat; (3S)-N-hydroxy-4-[4-(4-hydroxybut-2-ynoxy)phenyl]sulfonyl-2,2-dimethylthiomorpholine-3-carboxamide. Grades: 99%. CAS No. 287405-51-0. Molecular formula: C17H22N2O6S2. Mole weight: 414.5. | |
| TMP195 | TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor (IC50s = 59 nM, 60 nM, 26 nM and 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively), and is >100 fold selective over other HDACs (IC50 >10 μM). Synonyms: TMP195; TMP-195; TMP 195; N-[2-methyl-2-(2-phenyl-1,3-oxazol-4-yl)propyl]-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide; N-(2-Methyl-2-(2-phenyloxazol-4-yl)propyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide; N-[2-Methyl-2-(2-phenyloxazol-4-yl)propyl]-3-[5-(trifluoroMethyl)-1,2,4-oxadiazol-3-yl]benzaMide; TFMO 2. CAS No. 1314891-22-9. Molecular formula: C23H19F3N4O3. Mole weight: 456.42. | |
| TMP778 | TMP778 is a selective RORγt inverse agonist. TMP778 can selectively block mouse Th17 cell differentiation in vitro and impair Th17 cell development in vivo upon immunization with the myelin antigen MOG35-55 plus complete Freund's adjuvant. In addition, TMP778 can repress the expression of more than 150 genes, most of which fall outside the canonical Th17 transcriptional signature and are linked to a variety of inflammatory pathologies in humans. Synonyms: TMP778; TMP 778; TMP-778; 2- (2- ( (S)- (3, 5-dimethylisoxazol-4-yl) (hydroxy)methyl)benzofuran-5-yl)-N- ( (S)- (2, 4-dimethylphenyl) (phenyl)methyl)acetamide. Grades: 98%. CAS No. 1422171-08-1. Molecular formula: C31H30N2O4. Mole weight: 494.59. | |
| TMPH hydrochloride | TMPH hydrochloride is a potent and non-competitive antagonist of neuronal nicotinic ACh receptors (nAChRs). It produces long-lasting inhibition of neuronal nAChRs formed by the combination of the most abundant α and β subunits (i.e. α3, α4 and β2, β4 respectively). TMPH hydrochloride has the potential to treat progressive neurodegenerative disease such as globoid cell leukodystrophy (GLD) or Krabbe disease. Synonyms: 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate. Grades: ≥98% by HPLC. CAS No. 849461-91-2. Molecular formula: C16H31NO2.HCl. Mole weight: 305.88. | |
| Toceranib | Toceranib (CAS 356068-94-5) is a potent ATP-competitive PDGFR and VEGFR inhibitor (Ki = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (Ki = 0.5 μM). Effective in vivo. Synonyms: SU 11654; PHA 291639; SU11654; SU-11654; PHA-291639; PHA291639. Grades: >98%. CAS No. 356068-94-5. Molecular formula: C22H25FN4O2. Mole weight: 396.46. | |
| Tocrifluor T1117 | Tocrifluor T1117 is a fluorescent analog of AM 251, which is a GPR55 agonist and CB1 receptor antagonist. AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Synonyms: T1117, T 1117, T-1117; N- (Piperidin-1-yl) -5- (4- (4- (3- (5-carboxamidotetramethylrhodaminyl) propyl) ) phenyl) -1- (2, 4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide. Grades: ≥95% by HPLC. CAS No. 1186195-59-4. Molecular formula: C56H53Cl2N7O5. Mole weight: 974.97. | |
| Todralazine hydrochloride | Todralazine is a β2-adrenergic receptor antagonist used as an antihypertensive agent. It also exhibits some central nervous system depressant effects. Uses: Antihypertensive agents. Synonyms: Apirachol; Binazine; Ecarazine; Ethyl N-(phthalazin-1-ylamino)carbamate hydrochloride. Grades: ≥98%. CAS No. 3778-76-5. Molecular formula: C11H12N4O2·HCl. Mole weight: 268.7. | |
| Tolazoline | Tolazoline is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. Uses: A non-selective competitive α-adrenergic receptor antagonist. Synonyms: 2-benzyl-4,5-dihydro-1H-imidazole. Grades: ≥95%. CAS No. 59-98-3. Molecular formula: C10H12N2. Mole weight: 160.22. | |
| Tolazoline HCl | Cas No. 59-97-2. | |
| Tolbutamide | Tolbutamide is an inhibitor of potassium channel, used for type II diabetes. Uses: Hypoglycemic agents. Synonyms: tolbutamide; 64-77-7; Orinase; Arkozal; Willbutamide; Butamide; Diabetamid; Ipoglicone; Glyconon; Rastinon; Tolbutamid; Aglicid; Artosin; Diaben; Tolumid; 1-Butyl-3-tosylurea; Diasulfon; Artozin; Butamid; Diabetol; Diabuton; Dirastan; Dolipol; Mobenol; Oterben; Pramidex; Tolbusal; Toluina; Toluvan; Tolylsulfonylbutylurea; 1-Butyl-3-(p-tolylsulfonyl)urea; Drabet; Orabet; Oralin; Orezan; Orinaz; Tolbutamidum; Sk-tolbutamide; N-(Butylcarbamoyl)-4-methylbenzenesulfonamide; N-n-Butyl-N'-tosylurea; Tolbutamida; 1-p-Toluenesulfonyl-3-butylurea; 1-Butyl-3-(p-methylphenylsulfonyl)urea; Arcosal; Beglucin; Butamidum; Diabesan; N-Butyl-N'-(p-tolylsulfonyl)urea; Tarasina; Tolbutone; Tolbet; N-Butyl-N'-p-toluenesulfonylurea; 3-(p-Tolyl-4-sulfonyl)-1-butylurea; N-(4-Methylphenylsulfonyl)-N'-butylurea; N-Butyl-N'-(4-methylphenylsulfonyl)urea; HLS 831; N-(4-Methylbenzenesulfonyl)-N'-butylurea. Grades: >98%. CAS No. 64-77-7. Molecular formula: C12H18N2O3S. Mole weight: 270.35. | |
| Tolclofos-Methyl | Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide as an excellent foundation seed fungicide. Uses: An excellent foundation seed fungicide. Synonyms: Tolclofos-methyl; Rizolex; S-3349; S 3349; S3349; 2,6-dichloro-4-methylphenyl o,o-dimethyl phosphorothioate;Dimethyl O-(2,6-dichloro-4-methylphenyl) phosphorothioate;(2,6-dichloro-4-methylphenoxy)-dimethoxy-sulfanylidene-$l^{5}-phosphane. Grades: ≥95%. CAS No. 57018-04-9. Molecular formula: C9H11Cl2O3PS. Mole weight: 301.12. | |
| Toll-Like Receptor 7 Ligand II | Cas No. 226907-52-4. | |
| Toll-like receptor modulator | A TLR modulator. Synonyms: Ethyl 2-amino-8-(perfluoroethyl)-3H-benzo[b]azepine-4-carboxylate. CAS No. 926927-42-6. Molecular formula: C15H13F5N2O2. Mole weight: 348.27. | |
| Tolmetin sodium dihydrate | Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory agent for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. Uses: A non-steroidal anti-inflammatory agent. Synonyms: sodium;2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate;dihydrate. Grades: ≥98%. CAS No. 64490-92-2. Molecular formula: C15H18NNaO5. Mole weight: 315.30. | |
| Toloxatone | Toloxatone is a reversible monoamine oxidase A (MAOA) inhibitor that can be used as an antidepressant. Synonyms: Humoryl; Perenum; 5-(Hydroxymethyl)-3-(M-Tolyl)Oxazolidin-2-One. Grades: 98%. CAS No. 29218-27-7. Molecular formula: C11H13NO3. Mole weight: 207.23. | |
| Tolrestat | Tolrestat is an orally active and potent aldose reductase inhibitor with IC50 value of 35 nM. It was approved for the control of certain diabetic complications. It reduces RBC (red blood cells) sorbitol levels in rats. It decreased, in dose-related manner, the RBC sorbitol levels in normal and in streptozotocin diabetic rats. It failed a Phase III trial in the U.S. due to toxicity. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. Uses: Tolrestat was approved for the control of certain diabetic complications. Synonyms: AY 27773; AY-27773; AY27773; Tolrestat; AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat;2-[[6-methoxy-5-(trifluoromethyl)naphthalene-1-carbothioyl]-methylamino]acetic acid;N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine. Grades: 95%. CAS No. 82964-04-3. Molecular formula: C16H14F3NO3S. Mole weight: 357.35. | |
| Topterone | A steroidal antiandrogen drug. Synonyms: (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-17-propyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one; 17-propyltestosterone; topterone; Win 17,665. CAS No. 60607-35-4. Molecular formula: C22H34O2. Mole weight: 330.5. | |
| Torin 1 | Torin1 inhibits phosphorylation of mTORC1 and mTORC2 substrates in cells at concentrations of 2 and 10 nM, respectively. Synonyms: Torin-1; Torin1; Torin 1. Grades: >98%. CAS No. 1222998-36-8. Molecular formula: C35H28F3N5O2. Mole weight: 607.62. | |
| Tosylchloramide sodium trihydrate | A disinfectant agent widely used in laboratories, kitchens and hospitals. Synonyms: sodium; chloro-(4-methylphenyl)sulfonylazanide; trihydrate; (N-chloro-p-toluenesulfonamide)sodium; chloramine T; chloramine-T; chloramine-T anhydrous; chloramine-T, 36Cl-labeled; ClorinaL; Euclorina; Hydroclonazone; sodium p-toluenesulfonchloramide. CAS No. 7080-50-4. Molecular formula: C7H8ClNO2S.3H2O.Na. Mole weight: 310.80. | |
| Tozadenant | Tozadenant is an orally administered, potent and selective inhibitor of the adenosine 2a (A2a) receptor. Synonyms: RO-4494351; RO4494351; RO 4494351; SYN115; SYN-115; SYN 115; RO4494351-002; RO4494351-000; Tozadenant; 870070-55-6; 4-Hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide; UNII-D9K857J81I; SYN115. CAS No. 870070-55-6. Molecular formula: C19H26N4O4S. Mole weight: 406.49914. | |
| TP 003 | TP 003 is a selective GABAA receptor (α3 subtype) partial agonist with affinity for the benzodiazepine binding site on human GABAA receptors. TP 003 exhibits anxiolytic-like effects in rodent behavioral models of anxiety. Synonyms: 2',4-Difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]-pyridin-3-yl]-[1,1'-biphenyl]-2-carbonitrile. Grades: ≥98% by HPLC. CAS No. 628690-75-5. Molecular formula: C23H16F3N3O. Mole weight: 407.39. | |
| TP0427736 | TP0427736 is a potent and selective inhibitor of ALK5 kinase activity with IC50 value of 2.72 nM. It was shown to inhibit Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with IC50 value of 8.68 nM. Synonyms: TP 0427736; TP-0427736; 6-[5-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-4-yl]-1,3-benzothiazole. CAS No. 864374-00-5. Molecular formula: C14H10N4S2. Mole weight: 298.4. | |
| TP-472 | TP-472 is an inhibitor of bromodomain BRD9 and BRD7 bromodomain with Kd values of 33 and 340 nM, respectively. Synonyms: 3-(6-Acetylpyrrolo[1,2-a]pyrimidin-8-yl)-N-cyclopropyl-4-methylbenzamide. Grades: ≥98%. CAS No. 2079895-62-6. Molecular formula: C20H19N3O2. Mole weight: 333.4. | |
| TPA023 | TPA023, also called as MK-0777, is a subtype-selective, mixed agonist-antagonist at GABAA receptor with anxiolytic and anticonvulsant effects. Synonyms: 7-tert-butyl-6-[(2-ethyl-1,2,4-triazol-3-yl)methoxy]-3-(2-fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine; TPA023; TPA-023; TPA 023; MK0777; MK 0777; MK-0777; L830982; L-830982; L 830982. Grades: >98%. CAS No. 252977-51-8. Molecular formula: C20H22FN7O. Mole weight: 395.44. | |
| TPMPA | TPMPA is a selective and competitive GABAA-ρ antagonist with 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors. TPMPA exhibits minimal effects on GABAA and GABAB receptors (Kb = 2.1 μM (antagonist), 320 μM (antagonist) and EC50 ~ 500 μM (weak agonist) for GABAA-ρ, GABAA and GABAB receptors, respectively). Synonyms: (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid; methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid. Grades: ≥98% by HPLC. CAS No. 182485-36-5. Molecular formula: C6H12NO2P. Mole weight: 161.14. | |
| TPOP146 | TPOP146 is a potent and selective CBP/P300 benzoxazepine bromodomain inhibitor with Kd values of 134 nM and 5.02 μM for CBP and BRD4. TPOP146 targets the CBP bromodomain in the nucleus and is capable of competing with acetyl-lysine mediated interactions of the CBP bromodomain in cellular environments. Synonyms: TPOP146; TPOP-146; TPOP 146. 7-(3,5-dimethoxyphenyl)-N-[(3S)-1-methylpiperidin-3-yl]-4-propanoyl-3,5-dihydro-2H-1,4-benzoxazepine-9-carboxamide. CAS No. 2018300-62-2. Molecular formula: C27H35N3O5. Mole weight: 481.58. | |
| TQS | TQS is a type II positive allosteric modulator of α7 nACh receptors (pEC50 = 5.5) with no activity at α7 receptors at concentrations up to 0.1 mM. TQS potentiates agonist-evoked responses and reduces rate of desensitization of α7 nAChRs. Synonyms: 3a,4,5,9b-Tetrahydro-4-(1-naphthalenyl)-3H-cyclopentan[c]quinoline-8-sulfonamide. Grades: ≥98% by HPLC. CAS No. 353483-92-8. Molecular formula: C22H20N2O2S. Mole weight: 376.47. | |
| Trabodenoson | Trabodenoson is a selective adenosine A1 receptor agonist. Trabodenoson can significantly reduce IOP in glaucoma and OHT patients. Phase III clinical trials for Glaucoma and Ocular hypertension are on-going. Uses: Glaucoma; ocular hypertension. Synonyms: INNO-8875; INNO8875; INNO 8875; PJ 875; PJ-875; PJ875; Trabodenoson; ((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate. Grades: 95%. CAS No. 871108-05-3. Molecular formula: C15H20N6O6. Mole weight: 380.36. | |
| Tracazolate hydrochloride | Tracazolate hydrochloride is a subtype-selective GABAA receptor modulator that potentiates or inhibits recombinant GABAA function depending on subunit combination. Tracazolate hydrochloride enhances native GABAA receptor function, and exhibits anxiolytic activity following systemic administration in vivo. Uses: Anxiolytic. Synonyms: 4-(Butylamino)-1-ethyl-6-methyl 1H-pyrazolo[3,4b]pyridine-5-ethylcarboxylate hydrochloride; Ethyl 4-(butylamino)-1-ethyl-6-methylpyrazolo[3,4-b]pyridine-5-carboxylate hydrochloride. Grades: ≥99% by HPLC. CAS No. 1135210-68-2. Molecular formula: C16H24N4O2.HCl. Mole weight: 340.85. | |
| TRAM 39 | TRAM 39 is a potent intermediate conductance Ca2+-activated K+ channel (KCa3.1) blocker (Kd = 60 nM) with no effect on cytochrome p450 activity. TRAM 39 has been shown to inhibit I-EBIO-stimulated increases in rat artery membrane potential ex vivo, and also reduce LPS-induced cryptidin (mammalian α-defensin) release from paneth cells in vitro. Synonyms: TRAM39; TRAM-39; TRAM 39; 2-Chloro-α,α-diphenylbenzeneacetonitrile. Grades: ≥99% by HPLC. CAS No. 197525-99-8. Molecular formula: C20H14ClN. Mole weight: 303.78. | |
| Tranilast | Tranilast, also called Rizaben or Tranilastum, has anti-inflammatory and immunomodulatory effect. It binds to Aβ40 monomers and increases Aβ40 fibrillation. Synonyms: SB-252218; SB 252218; SB252218; MK-341; MK 341; MK341; 2-[[(E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid; tranilast; Rizaben; 53902-12-8; Tranilastum; N-(3,4-Dimethoxycinnamoyl)anthranilic acid; SB-252218; MK 341; C18H17NO5; 3,4-DAA; Tranilastum [INN-Latin]; MK-341; Rizaben (TN); Tranilast [USAN:INN:JAN]; Tranilast (trans-); MLS000028468; S1439_Selleck; AC1NQZP4; UNII-HVF50SMY6E; SBB052710; HVF50SMY6E; Lopac0_001193; NCGC00018185-05; BSPBio_003561; SMR000058373; T0318_SIGMA; SPECTRUM1505333; MLS000759509:N-(3',4'-dimethoxycinnamoyl)anthranilic acid; tranilast; tranilast hydrate; tranilast sodium salt. CAS No. 53902-12-8. Molecular formula: C18H17NO5. Mole weight: 327.34. | |
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