BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Camylofine | Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscle spasm. Synonyms: Camylofine; Acamylophenine; Adopon; Avacan; Novospasmin; 3-methylbutyl 2-[2-(diethylamino)ethylamino]-2-phenylacetate. CAS No. 54-30-8. Molecular formula: C19H32N2O2. Mole weight: 320.477. |  |
| Camylofine dihydrochloride | Camylofine dihydrochloride is the salt form of Camylofine. Camylofine is an antimuscarinic with both anticholinergic action as well as direct smooth muscle action. It can be used to treat the pain caused by smooth muscle spasm. Synonyms: 3-Methylbutyl {[2- (diethylamino)ethyl]amino} (phenyl)acetate dihydrochloride. CAS No. 5892-41-1. Molecular formula: C19H34Cl2N2O2. Mole weight: 393.393. | |
| Canertinib dihydrochloride | Canertinib dihydrochloride is the hydrochloride salt of an orally bio-available quinazoline with potential antineoplastic and radiosensitizing activities. Canertinib binds to the intracellular domains of epidermal growth factor receptor tyrosine kinases (ErbB family), irreversibly inhibiting their signal transduction functions and resulting in tumor cell apoptosis and suppression of tumor cell proliferation. This agent also acts as a radiosensitizing agent and displays synergistic activity with other chemotherapeutic agents. Uses: Antineoplastic agents. Synonyms: N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; CI1033PD183805. Grades: ≥98% (HPLC). CAS No. 289499-45-2. Molecular formula: C24H27Cl3FN5O3. Mole weight: 558.86. | |
| Cangrelor | Cangrelor, an adenylic acid derivative, has been found to be a P2Y12 inhibitor that could be effective in some coronary artery diseases. It is approved by FDA as an antiplatelet drug. It has been used to reduce the risk of heart attack during cardiology procedures. Synonyms: Kengreal; UNII-6AQ1Y404U7; AR-C69931XX; AR-C69931MX; [dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid. Grades: ≥98%. CAS No. 163706-06-7. Molecular formula: C17H25Cl2F3N5O12P3S2. Mole weight: 776.37. | |
| CAP 3 | CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increases the fluidity of model Gram-negative bacterial membranes and binds to LPS in vitro. It reduces the biomass and number of colony-forming units in E. coli biofilms in a concentration-dependent manner. CAP 3 inhibits E. coli biofilm formation on catheters implanted in mice infected with E. coli at the incision site when applied as a coating on the catheters. CAP 3 (40 mg/kg) also reduces bacterial load in E. coli-infected wounds in mice. It is cytotoxic to A459 cells (IC50 = 56.4 μM) and has hemolytic activity against human red blood cells with a 50% lysis (HC50) value of 48 μM. Synonyms: CAP 3; CHEMBL5173640; benzyl (4R)-4-[(3R, 5S, 7R, 8R, 9S, 10S, 12S, 13R, 14S, 17R)-3, 7, 12-tris[[2-[(2-amino-3-methylbutanoyl)amino]acetyl]oxy]-10, 13-dimethyl-2, 3, 4, 5, 6, 7, 8, 9, 11, 12, 14, 15, 16, 17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate. Grades: ≥98%. Molecular formula: C52H82N6O11. Mole weight: 967.3. | |
| Capadenoson | Capadenoson is a potent and selective adenosine A1 receptor agonist, which is a powerful protective mechanism in cerebral. Uses: Adenosine a1 receptor agonist. Synonyms: BAY 68-4986; BAY-68-4986; BAY68-4986; Capadenoson2-Amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-3,5-pyridinedicarbonitrile;2-Amino-6-[[[2-(4-chlorophenyl)-4-thiazolyl]methyl]thio]-4-[4-(2-hydroxyethoxy)phenyl]-3,5-pyridinedicarbonitrile. Grades: ≥95%. CAS No. 544417-40-5. Molecular formula: C25H18ClN5O2S2. Mole weight: 520.03. | |
| Capmatinib | Capmatinib, also known as INCB28060 and INC280, is an orally bioavailable inhibitor of the proto-oncogene c-Met (hepatocyte growth factor receptor [HGFR]) with potential antineoplastic activity. It selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis. It has been granted Breakthrough Therapy Designation by FDA as a first-line treatment for patients with metastatic MET exon14 skipping-mutated non-small cell lung cancer (NSCLC). Synonyms: INCB28060; INC-280; INC280. CAS No. 1029712-80-8. Molecular formula: C23H17FN6O. Mole weight: 412.43. | |
| Capsazepine | Capsazepine, a benzazepine derivative, has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. IC50: 562 nM (Rat TRPV1). Uses: Capsazepine has been found to be a sensory neurone excitotoxin that could be used against hyperalgesic responses. Synonyms: N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide. Grades: > 95%. CAS No. 138977-28-3. Molecular formula: C19H21ClN2O2S. Mole weight: 376.91. | |
| Capsiconiate | Capsiconiate is a coniferyl ester that has been isolated from certain plants in the Solanaceae family, including plants in the genus Capsicum. It is a TRPV1 agonist, non-selective cation and calcium permeable channel. Like capsaicin, capsiconiate is an agonist of the transient receptor potential vanilloid receptor TRPV1 (EC50 = 3.2 μM). But the maximum response induced by capsiconiate through TRPV1 is only 20% of that of capsaicin. Synonyms: Coniferyl (E)-8-methyl-6-nonenoate. Grades: ≥98%. CAS No. 946572-73-2. Molecular formula: C20H28O4. Mole weight: 332.4. | |
| Carabersat | Carabersat, also called as SB 204269, an orally-effective anticonvulsant agent, is an ATP-sensitive potassium channel (K-ATP) opener with potential effect to treat epilepsy. Synonyms: N-[(3R,4S)-6-acetyl-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-4-fluorobenzamide; Carabersat; Sb 204269-eo; SB-204269; SB 204269; SB204269. Grades: 95%. CAS No. 184653-84-7. Molecular formula: C20H20FNO4. Mole weight: 357.38. | |
| Carazolol | Carazolol is a β-adrenergic receptor antagonist. Uses: Adrenergic beta-antagonists. Synonyms: Carazolol; BM 51052; CCRIS 1047; BM51052; CCRIS1047; BM-51052; CCRIS-1047; 1-(9H-Carbazol-4-yloxy)-3-isopropylaminopropan-2-ol. CAS No. 57775-29-8. Molecular formula: C18H22N2O2. Mole weight: 298.386. | |
| Carbazeran citrate | The citrate salt form of Carbazeran, which has been found to be an aldehyde oxidase (AO) substrate as well as a non-specific PDE inhibitor. Synonyms: Ethyl 1-(6,7-dimethoxy-1-phthalazinyl)-4-piperidinyl carbamate citrate. Grades: ≥98% by HPLC. CAS No. 153473-94-0. Molecular formula: C18H24N4O4.C6H8O7. Mole weight: 552.53. | |
| Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome | Carbobenzoxy-Pro-Lys-Phe-Y(Po2)-Ala-Pro-Ome is an intricate biomedical substance, finding utility in studying cancer and autoimmune ailments. It actively operates as a potent inhibitor, selectively targeting enzymes or pathways implicated in the advancement of such afflictions. Synonyms: Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate. Molecular formula: C36H52N6O9P. Mole weight: 743.81. | |
| Carboprost | Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties. It is a potent uterine stimulant and abortifacient which can be given intramuscularly to induce labor. It can also induce luteolysis and reduces serum progesterone concentrations. Uses: Oxytocics. Synonyms: CARBOPROST; 35700-23-3; Carboprostum; Prostin 15M; 15-ME-PGF2-alpha; UNII-7B5032XT6O; (15S)-15-Methylprostaglandin F2alpha; 15-Methylprostaglandin F2-alpha; (15S)-15-Methyl-PGF2alpha; 7B5032XT6O; 15-methyl-pgf2.alpha.; 15(S)-Methylprostaglandin F2-alpha; Carboprostum [INN-Latin]; U 32921; BRN 2949991; U-32,921; 15-methyl-15S-PGF2alpha; CHEBI:3403; (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxy-3-methyloct-1-enyl]cyclopentyl]hept-5-enoic acid; DTXSID4022739; (15S)-15-Methylprostaglandin F(sub 2alpha); 15-methylprostaglandin f2.alpha.; (15s)-15-methyl-pgf2.alpha.; U-32921; 15-methyl-15S-Prostaglandin F2alpha. CAS No. 35700-23-3. Molecular formula: C21H36O5. Mole weight: 368.51. | |
| Carboxypeptidase G2 (CPG2) Inhibitor | A novel Carboxypeptidase G2 (CPG2) Inhibitor, Antitumor agents. Synonyms: CPG2 Inhibitor; L-Glutamic acid, N-[[(4-methoxyphenyl)thio]carbonyl]-. Grades: >98%. CAS No. 192203-60-4. Molecular formula: C13H15NO6S. Mole weight: 313.33. | |
| Carcinine ditrifluoroacetate | The ditrifluoroacetate salt form of Carcinine, which is a highly selective histamine H3 receptor antagonist and could act as a natural antioxidant. Synonyms: 3-Amino-N-[2-(1H-imidazol-4-yl)ethyl]propanamide ditrifluoroacetate. Grades: ≥98% by HPLC. CAS No. 56897-53-1. Molecular formula: C8H14N4O.2CF3CO2H. Mole weight: 410.27. | |
| Carebastine | Carebastine is the active first-pass metabolite of Ebastine. Carebastine acts as a selective histamine H1 receptor antagonist that has the potential for allergy therapy. Uses: Histamine h1 antagonists. Synonyms: 2-[4-[4-(4-benzhydryloxypiperidin-1-yl)butanoyl]phenyl]-2-methylpropanoic acid. CAS No. 90729-42-3. Molecular formula: C32H37NO4. Mole weight: 499.651. | |
| Carfilzomib Impurity 13 hydrochloride | Carfilzomib is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. It is a second-generation and peptide epoxyketone class proteasome inhibitor that targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome with IC50 of 5.2 nM. Carfilzomib impurity 13 hydrochloride is a potential impurity found in commercial carfilzomib preparations. Grades: ≥95%. CAS No. 2319881-95-1. Molecular formula: C16H22N2O4·HCl. Mole weight: 342.8. | |
| Cariporide | Cariporide, also known as HOE-642, is a selectiveNa+/H+exchange inhibitor, also known as the Na+/H+ antiporter, which functions to improve cellular integrity following events of cardiac ischemia and reperfusion. It plays an important role in the myocardial response to ischemia-reperfusion. Synonyms: N-(diaminomethylidene)-3-methylsulfonyl-4-propan-2-ylbenzamide; 4-isopropyl-3-(methylsulfonyl)benzoyl-guanidine methanesulfonate; cariporide; HOE 642; HOE-642; HOE642. CAS No. 159138-80-4. Molecular formula: C12H17N3O3S. Mole weight: 283.35. | |
| CARM1-IN-1 | CARM1-IN-1 is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 μM and shows very low activity against PRMT1 and SET7(IC50>600 μM). Synonyms: CARM1-IN-7G; CARM1IN7G; CARM1 IN 7G; CARM1-inhibitor-7G; CARM1 inhibitor 7G. Grades: >98%. CAS No. 1020399-49-8. Molecular formula: C26H21Br2NO3. Mole weight: 555.26. | |
| Carmofur | Carmofur or HCFU is a pyrimidine analogue used as an antineoplastic agent. It is a derivative of fluorouracil. Uses: Antineoplastic agents. Synonyms: HCFU. Grades: >98%. CAS No. 61422-45-5. Molecular formula: C11H16FN3O3. Mole weight: 257.26. | |
| Carmoterol | Carmoterol, a quinolin derivative, has been found to a β2-adrenoceptor agonist that could be an effective bronchodilating agent. Synonyms: Carmoterol;8-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone. Grades: 98%. CAS No. 147568-66-9. Molecular formula: C21H24N2O4. Mole weight: 368.43. | |
| Carmoxirole hydrochloride | The hydrochloride salt form of Carmoxirole , which is a selective, peripherally acting dopamine D2 receptor agonist and exhibits antihypertensive activities in vivo. Synonyms: 1H-Indole-5-carboxylic acid, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-, hydrochloride (1:1); 1H-Indole-5-carboxylic acid, 3-[4-(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-, monohydrochloride; Carmoxirole monohydrochloride; EMD 45609; 3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indole-5-carboxylic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 115092-85-8. Molecular formula: C24H26N2O2.HCl. Mole weight: 410.94. | |
| Carvedilol EP impurity E | Carvedilol is a beta-blocker. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Carvedilol is used to treat heart failure and hypertension (high blood pressure). It is also used after a heart attack that has caused your heart not to pump as well. Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). Carvedilol EP impurity E is an impurity of Carvedilol. Synonyms: Carvedilol Impurity E; Carvedilol USP E. Grades: ≥95%. CAS No. 64464-07-9. Molecular formula: C9H14ClNO2. Mole weight: 203.67. | |
| Carvedilol Phosphate | Carvedilol phosphate hemihydrate is a nonselective beta (β1, β2) blocker and alpha (α1) blocker, inhibits LDL oxidation (IC50 = 3.8 μM). Uses: Nonselective beta (β1, β2) blocker and alpha (α1) blocker. Synonyms: 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;phosphoric acid;hydrate. Grades: ≥98%. CAS No. 610309-89-2. Molecular formula: C24H26N2O4·H2O·H3O4P. Mole weight: 522.488. | |
| Caspase-3/7 Inhibitor I | Caspase-3/7 inhibitor I is a potent, reversible, isatin sulfonamide-based inhibitor of caspase-3 (Ki(app) = 60 nM; IC50 = 120 nM) and caspase-7 (Ki(app) = 170 nM). It is a weaker inhibitor of caspase-9 with Ki(app) of 3.1 μM and caspase-1, caspase-2, caspase-4, caspase-6, and caspase-8 (Ki(app)s ≥25 μM). The basis for the unique selectivity of this compound for caspases 3 and 7 involves the recognition of three distinct hydrophobic residues in the S2 pocket surrounding the catalytic cysteine residue. Grades: ≥98%. CAS No. 1110670-49-9. Molecular formula: C14H16N2O5S. Mole weight: 324.4. | |
| CaSR antagonist 18c | A calcium-sensing receptor (CaSR) antagonist (IC50 = 76 nM) potentially used as an anabolic agent for the treatment of osteoporosis. Uses: Potential anabolic agent for osteoporosis. Grades: 99%. CAS No. 802916-30-9. Molecular formula: C32H35N3O6. Mole weight: 557.64. | |
| Cathepsin G Inhibitor I | Cathepsin G inhibitor I is a potent and selective inhibitor of cathepsin G with IC50 of 53 nM. It weakly inhibits chymotrypsin and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase. Synonyms: Cathepsin G Inhibitor I; 429676-93-7; Cathepsin G Inhibitor; CHEMBL164694; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid; SCHEMBL1613660; DTXSID80431393; BDBM50139754; HY-103351; CS-0027703; A918760; (2-{3-[(1-Benzoyl-piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl}-1-naphthalen-1-yl-2-oxo-ethyl)-phosphonic acid; [2-[3-[(1-benzoylpiperidin-4-yl)-methylcarbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2 oxoethyl]phosphonic acid. Grades: ≥95%. CAS No. 429676-93-7. Molecular formula: C36H33N2O6P. Mole weight: 620.6. | |
| Cathepsin Inhibitor 1 | Osteoarthritis is currently recognized as a chronic degenerative disease, which is caused by the loss of articular cartilage and damage to underlying bone, resulting in joint instability and pain. Cathepsin Inhibitor 1 is an inhibitor of Cathepsin. The IC50s for Cathepsin L, L2, S, K, B are 7.9, 6.7, 6.0, 5.5 and 5.2 nM, respectively. Synonyms: Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1. Grades: ≥98%. CAS No. 225120-65-0. Molecular formula: C20H24ClN5O2. Mole weight: 401.89. | |
| Cathepsin L Inhibitor | Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone. Synonyms: Z-FY-CHO; Z-Phe-Tyr-aldehyde; SB 412515; N-(benzyloxycarbonyl)-phenylalanyl-l-tyrosinal. Grades: ≥95%. CAS No. 167498-29-5. Molecular formula: C26H26N2O5. Mole weight: 446.49. | |
| CAY10398 | CAY10398 is an inhibitor of histone deacetylase (HDAC1) with an IC50 value of 10 μM. It has equivalent selectivity and is much more cost-effective for the inhibition of HDAC. The deacetylation of histones by HDAC is associated with transcriptional silencing. Synonyms: MD 85; PX 089274. Grades: ≥98%. CAS No. 193551-00-7. Molecular formula: C15H23N3O3. Mole weight: 293.4. | |
| CAY10401 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10401 is a selective, potent inhibitor of rat FAAH exhibiting a Ki value of 0.14 nM. It is approximately 580-fold more potent than oleyl trifluoromethyl ketone. Synonyms: CAY 10401; CAY-10401; 1-oxazolo[4,5-b]pyridin-2-yl-9-octadecyn-1-one. Grades: ≥98%. CAS No. 288862-89-5. Molecular formula: C24H34N2O2. Mole weight: 382.5. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grades: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| CAY10435 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10435 is a selective, potent inhibitor of rat FAAH with Ki value of 0.57 nM. It exhibited IC50 values of 0.81 nM, 83 nM, and 50 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Synonyms: CAY 10435; CAY-10435. Grades: ≥98%. CAS No. 288862-73-7. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| CAY10443 | Mitochondrial release of cytochrome c triggers apoptosis including caspase-9, which is called the apoptosome. Apoptotic activators represent therapeutic lead compounds for the development of antitumor drugs. CAY10443 is an apoptotic activators and activated caspase-3 with an EC50 of 5 μM. Synonyms: (S)-Indan-1-yl 3,4-dichlorobenzylcarbamate. Grades: ≥98%. CAS No. 582314-48-5. Molecular formula: C17H15Cl2NO2. Mole weight: 336.2. | |
| CAY10498 | The A1, A2A, A2B, and A3 adenosine receptors (ARs) are ubiquitous G protein-coupled receptors. A3 AR antagonists are of interest as therapeutic agents in glaucoma agents and inflammation. CAY10498 is a potent and selective Adenosine A3-R (A3 AR) antagonist exhibiting a Ki of 37 nM. It is 60 and 200-fold selectivity over A1 and A2A adenosine receptors, respectively. CAY10498 is also a structural analog of reversine, which is a dedifferentiation agent of embryonic progenitor cells. Synonyms: 2-phenyl-amino-N6-endo-norbornyladenine. Grades: ≥95%. CAS No. 863202-33-9. Molecular formula: C18H20N6. Mole weight: 320.4. | |
| CAY10502 | Phospholipases A2 (PLA2s) are enzymes that cleave fatty acid in position two of phospholipids, hydrolyzing the bond between the second fatty acid "tail" and the glycerol molecule. It catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. CAY10502 is a potent Calcium-dependent cytosolic PLA2 (cPLA2α) inhibitor with IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits arachidonic acid mobilization from A23187-stimulated or TPA-stimulated human platelets with IC50 values of 570 and 0.9 nM, respectively. Synonyms: CAY10502; CAY-10502. Grades: ≥98% (mixture of isomers). CAS No. 888320-29-4. Molecular formula: C30H37NO7. Mole weight: 523.6. | |
| CAY10505 | CAY10505 is a phosphatidylinositol 3-kinase-γ inhibitor, was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505, may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3Kγ might be a useful approach in the therapeutics of vascular endothelium dysfunction. Synonyms: CAY10505; CAY 10505; CAY-10505. Grades: 0.98. CAS No. 1218777-13-9. Molecular formula: C14H8FNO3S. Mole weight: 289.28. | |
| CAY10506 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10506 is a PPARγ agonist, which is a nuclear transcription factor that controls lipid homeostasis and glucose metabolism. It is a hybrid lipoic acid (anti-diabetic drugs of the thiazolidinedione) TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM. Synonyms: CAY 10506; CAY-10506. Grades: ≥98%. CAS No. 292615-75-9. Molecular formula: C20H26N2O4S3. Mole weight: 454.6. | |
| CAY10508 | Cannabinoid receptor type 1 (CB1) is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. The human CB1 receptor is expressed in the peripheral nervous system and central nervous system. CAY10508 is a potent and selective central cannabinoid (CB1) receptor inverse agonist with a Ki value of 243 nM and an EC50 of 195 nM. Synonyms: CAY 10508; CAY-10508. Grades: ≥98%. CAS No. 878533-35-8. Molecular formula: C21H14Br2N2O2. Mole weight: 486.2. | |
| CAY10509 | Prostaglandin F2α (PGF2α in prostanoid nomenclature) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. CAY10509 is an analog of PGF2α containing a thio-fluorobenzene substituent in the lower side chain, which has an IC50 of about 30 nM for binding to the recombinant human FP receptor. Synonyms: CAY 10509; CAY-10509. Grades: ≥98%. CAS No. 1245699-47-1. Molecular formula: C23H35FO5S. Mole weight: 442.6. | |
| CAY10510 | Prostaglandin F2α (PGF2α in prostanoid nomenclature) is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. CAY10510 is an analog of PGF2α containing an acetylenic fluorobenzene substituent in the lower side chain, which has an IC50 of 0.5 nM when tested for binding to the recombinant human FP receptor. Synonyms: CAY 10510; CAY-10510. Grades: ≥98%. CAS No. 291303-34-9. Molecular formula: C24H33FO5. Mole weight: 420.5. | |
| CAY10512 | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. CAY10512 is an analog of Resveratrol that is 100-fold more potent (IC50 = 150 nM) at inhibiting NF-κB activation by TNF-&alpha. Unlike Resveratrol and some other trans-stilbene analogs, CAY10512 does not exhibit antioxidant activity (up to 15 μM) in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays. Synonyms: (E)-2-Fluoro-4?-methoxystilbene. Grades: ≥97%. CAS No. 139141-12-1. Molecular formula: C15H13FO. Mole weight: 228.3. | |
| CAY10514 | 8(S)-HETE is a strong activator of peroxisome proliferator-activated receptors α (PPARα) and a weak activator of peroxisome proliferator-activated receptors γ (PPARγ). CAY10514 is an aromatic analog of 8(S)-HETE, which acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively. Synonyms: Methyl-8-hydroxy-8-(2-pentyl-oxyphenyl)-oct-5-ynoate. Grades: ≥98%. CAS No. 868526-38-9. Molecular formula: C20H28O4. Mole weight: 332.4. | |
| CAY10554 | Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. CAY10554 is a potent inhibitor of Cdk5 and Cdk2, with IC50 values of 64 and 98 nM, respectively. Synonyms: BML-259; BML 259; CAY 10554; CAY-10554. Grades: ≥95%. CAS No. 267654-00-2. Molecular formula: C14H16N2OS. Mole weight: 260.4. | |
| CAY10561 | The extracellular signal-regulated kinases (ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 with Ki of 2 nM. It is highly selective for ERK2 and inhibits proliferation of COLO 205 cells with IC50 of 0.54 μM. Synonyms: Pyrazolylpyrrole ERK Inhibitor; CAY 10561; CAY-10561. Grades: ≥98%. CAS No. 933786-58-4. Molecular formula: C22H17Cl2FN4O2. Mole weight: 459.3. | |
| CAY10567 | AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. CAY10567 is an AKT1 translocation inhibitor. It can prevent the translocation of AKT1 by apparently compromising the function of the PH domain. CAY10567 also inhibits hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) with an IC50 value of 79 μM. Synonyms: BML-257. Grades: ≥98%. CAS No. 32387-96-5. Molecular formula: C21H14N2O2. Mole weight: 326.4. | |
| CAY10570 | Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. CAY10570 is a reversible competitive inhibitor of FAAH activity exhibiting an IC50 value of 1.3 μM. It has no affinity for the human CB1 receptor and acts as a competitive inhibitor of FAAH activity without being hydrolyzed. Synonyms: CAY 10570; CAY-10570. Grades: >98%. CAS No. 875014-22-5. Molecular formula: C25H32N2OS. Mole weight: 408.6. | |
| CAY10571 | CAY10571 is a cell-permeable, reversible, and ATP-competitive sulfone analog of the p38 MAP kinase inhibitor. It is an analog of SB203580, which inhibits IL-1 production in the human monocytic cell line THP with an IC50 value of 0.20 μM and binds CSAID binding protein. Synonyms: CAY 10571; CAY-10571. Grades: ≥95%. CAS No. 152121-46-5. Molecular formula: C21H16FN3O2S. Mole weight: 393.4. | |
| CAY10573 | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/&delta. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It shows stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM). Synonyms: CAY 10573; CAY-10573. Grades: ≥98%. CAS No. 853652-40-1. Molecular formula: C33H31NO5. Mole weight: 521.6. | |
| CAY10574 | Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. They are key regulators of cell cycle progression and are therefore promising therapeutic targets for cancer and neurodegenerative diseases. CAY10574, also known as Cdk9 Inhibitor II, is a potent, selective inhibitor with an IC50 of 0.35 μM. It is also a competitive inhibitor of Cdk2-cyclin E with Ki of 13.3 μM and IC50 values 20 μM. Synonyms: CAY 10574; CAY-10574; Cdk9 Inhibitor II. Grades: ≥95%. CAS No. 140651-18-9. Molecular formula: C9H10N6O. Mole weight: 218.2. | |
| CAY10575 | NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is activated upon degradation of IκB following IKK-α and IKK-β phosphorylation. IKK-ε, a homolog of IKK-α and IKK-β, can also activate NF-κB. CAY10512 is an analog of Resveratrol that is 100-fold more potent with IC50 of 150 nM at inhibiting NF-κB activation by TNF-&alpha. It does not exhibit antioxidant activity in either the ferric reducing/antioxidant power (FRAP) or total radical antioxidant parameter (TRAP) assays. Synonyms: CAY 10575; CAY-10575. Grades: ≥95%. CAS No. 916985-21-2. Molecular formula: C22H21N3O6S2. Mole weight: 487.6. | |
| CAY10580 | Prostaglandin E2 is a naturally occurring prostaglandin which is used as a medication. As a medication it is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor with Ki of 35 nM. Synonyms: CAY 10580; CAY-10580. Grades: ≥96%. CAS No. 64054-40-6. Molecular formula: C19H35NO4. Mole weight: 341.5. | |
| CAY10583 | Leukotriene B4 (LTB4) is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue. CAY10583 is a selective and synthetic LTB4 agonist with EC50 of 20 nM. Synonyms: CAY 10583; CAY-10583. Grades: ≥98%. CAS No. 862891-27-8. Molecular formula: C25H25NO3. Mole weight: 387.5. | |
| CAY10589 | CAY10589 is a dual inhibitor of mPGES-1 with IC50 of 1.3 μM and 5-LO with IC50 of 1.0 μM. It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively. Synonyms: CAY 10589; CAY-10589. Grades: ≥98%. CAS No. 1077626-52-8. Molecular formula: C25H28ClN3O2S. Mole weight: 470. | |
| CAY10590 | Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, liberating arachidonic acid for subsequent eicosanoid synthesis. There are three primary types of PLA2 exist: secretory (sPLA2), calcium-dependent cytosolic (cPLA2), and calcium-independent cytosolic (iPLA2). CAY10590 is a selective and potent inhibitor of sPLA2. It exhibits 95% inhibition (XI(50) = 0.003) of sPLA2 at 0.091 mole fraction without affecting the activities of cPLA2 or iPLA2. Synonyms: CAY 10590; CAY-10590. Grades: ≥98%. CAS No. 1101136-50-8. Molecular formula: C21H33NO3. Mole weight: 347.5. | |
| CAY10591 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. SIRT1 Activator 3 is a member of the sirtuins (SIRTs), which is a distinctive class of trichostatin A-insensitive lysyl-deacetylases. CAY10591 has been shown to increase fluorescence by 233% in a SIRT1 activity assay, and to suppress TNF-α in a dose-dependent manner. It suppresses TNF-α in a dose-dependent manner. Uses: Enzyme activators. Synonyms: SIRT1 Activator 3; Sirtuin 1 Activator 3; CAY 10591; CAY-10591. Grades: ≥98%. CAS No. 839699-72-8. Molecular formula: C20H25N5O2. Mole weight: 367.5. | |
| CAY10592 | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/&delta. CAY10592 is a full PPARδ agonist with EC50 of 30 nM in a fatty acid oxidation assay of rat L6 muscle cells with desirable oral pharmacokinetic properties. Synonyms: CAY 10592; CAY-10592. Grades: ≥98%. CAS No. 685139-10-0. Molecular formula: C23H17Br2ClO3S. Mole weight: 568.7. | |
| CAY10594 | Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. There are two mammalian isoforms of PLD, which are PLD1 and PLD2. CAY10594 is a potent phospholipase D2 inhibitor (PLD2), which also prevents the invasive migration of breast cancer cells. It ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Synonyms: CAY 10594; CAY-10594. Grades: ≥98%. CAS No. 1130067-34-3. Molecular formula: C26H28N4O2. Mole weight: 428.5. | |
| CAY10599 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at PPARγ with an EC50 of 0.05 μM. It shows high selectivity for the PPARγ receptor over PPARβ (EC50 > 10 μM) or PPARα (EC50 = 3.99 μM). Synonyms: CAY 10599; CAY-10599. Grades: ≥98%. CAS No. 1143573-33-4. Molecular formula: C38H41NO5. Mole weight: 591.7. | |
| CAY10602 | Sirtuins (SIRTs) are a family of proteins that regulate cellular health. Sirtuins play a key role in regulating cellular homeostasis. CAY10602 is a cell-permeable pyrroloquinoxaline compound that acts as a reversible SIRT1 activator and enhances fat mobilization in fully differentiated 3T3L1 fibroblasts. CAY10602 is at least 10 times more potent as a suppressor of TNF-α release than resveratrol. Synonyms: CAY 10602; CAY-10602. Grades: ≥95%. CAS No. 374922-43-7. Molecular formula: C22H15FN4O2S. Mole weight: 418.4. | |
| CAY10603 | CAY10603 is a potent and selective inhibitor of HDAC6 with IC50 of 2 pM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively. Uses: Histone deacetylase inhibitors. Synonyms: CAY10603; CAY-10603; CAY 10603. Grades: >98%. CAS No. 1045792-66-2. Molecular formula: C22H30N4O6. Mole weight: 446.5. | |
| CAY10606 | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM). It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 with IC50 of 1.6 μM. Synonyms: CAY 10606; CAY-10606. Grades: ≥98%. CAS No. 1159576-98-3. Molecular formula: C22H18ClNO3. Mole weight: 379.8. | |
| CAY10608 | The N-methyl-D-aspartate receptor (NMDA) is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. NMDA is Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors with IC50 of 50 nM. Synonyms: CAY 10608; CAY-10608. Grades: ≥98%. CAS No. 457897-92-6. Molecular formula: C18H22Cl2N2O4S. Mole weight: 433.4. | |
| CAY10614 | Lipid A is a lipid component of an endotoxin held responsible for the toxicity of gram-negative bacteria. It is the innermost of the three regions of the lipopolysaccharide (LPS), also called endotoxin molecule, and its hydrophobic nature allows it to anchor the LPS to the outer membrane. A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM. It does not significantly affect HEK cell viability. Synonyms: CAY 10614; CAY-10614. Grades: ≥98%. CAS No. 1202208-36-3. Molecular formula: C42H78INO2. Mole weight: 756. | |
| CAY10622 | Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton. Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions. CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively. Synonyms: CAY 10622; CAY-10622. Grades: ≥98%. CAS No. 1038549-25-5. Molecular formula: C25H25N5O3. Mole weight: 443.5. | |
| CAY10626 | Phosphatidylinositol 3-kinases (PI3K) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. PI3K catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. CAY10626 demonstrates IC50 values of <3 and 13 nM for MDA361 (breast) and PC3 (prostate) cancer cell lines, respectively. Synonyms: CAY 10626; CAY-10626. Grades: ≥98%. CAS No. 1202884-94-3. Molecular formula: C31H35F3N8O3. Mole weight: 624.7. | |
| CAY10638 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with IC50 of 31 nM. Synonyms: CAY 10638; CAY-10638. Grades: ≥98%. CAS No. 1221413-57-5. Molecular formula: C16H13NO3S2. Mole weight: 331.4. | |
| CAY10649 | Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme that in humans is encoded by the ALOX5 gene. 5-LO initiates the synthesis of (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10649 is a thiazolinone compound that demonstrates direct inhibition of 5-lipoxygenase (5-LO) product formation in intact polymorphonuclear leukocytes (PMNL) with IC50 of 0.28 μM. Synonyms: CAY 10649; CAY-10649. Grades: ≥98%. CAS No. 1272519-89-7. Molecular formula: C17H12ClNO2S. Mole weight: 329.8. | |
| CAY10650 | Cytosolic phospholipase A2α (cPLA2α) specifically catalyzes the hydrolysis of arachidonic acid from the sn-2-ester position of membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins and leukotrienes, both important mediators of the inflammatory process. CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor. It demonstrates strong anti-inflammatory effects when applied topically at a dose of 0.1 mg/ear in a mouse model of acute irritant contact dermatitis. Synonyms: CAY 10650; CAY-10650. Grades: >98%. CAS No. 1233706-88-1. Molecular formula: C28H25NO6. Mole weight: 471.5. | |
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