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(2R) -2-[[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]methyl]-4-propylidene-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Lincomycin, which is a lincosamide antibiotic from the actinomycete Streptomyces lincolnensis. Synonyms: tert-butyl (R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-propylidenepyrrolidine-1-carboxylate; 2-Methyl-2-propanyl (2R)-2-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-4-propylidene-1-pyrrolidinecarboxylate; 1-Pyrrolidinecarboxylic acid, 2-[[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-4-propylidene-, 1,1-dimethylethyl ester, (2R)-. Molecular formula: C19H37NO3Si. Mole weight: 355.59.
(2R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine is an intermediate in the preparation of Aprepitant, a novel selective neurokinin-1 (NK-1) receptor antagonist. Uses: Intermediate in the preparation of enantiomerically pure aprepitant diastereomers and derivatives. Synonyms: Aprepitant dehydro dealkyl; Desfluro Aprepitant; 2H-1,4-Oxazine, 2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-, (2R)-; (R)-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-5-(4-fluorophenyl)-3,6-dihydro-2H-1,4-oxazine; 2alpha-[(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-5,6-dihydro-2H-1,4-oxazine; Aprepitant Impurity 6. Grades: ≥95%. CAS No. 380499-07-0. Molecular formula: C20H16F7NO2. Mole weight: 435.33.
An impurity of safinamide, which is a selective monoamine oxidase B inhibitor reducing degradation of dopamine. Synonyms: Safinamide Impurity 4; (R)-N2-{4-[(3-fluorobenzyl)oxy]benzyl}alaninamide. Grades: ≥ 98%. CAS No. 174756-44-6. Molecular formula: C17H19FN2O2. Mole weight: 302.349.
Pivmecillinam EP Impurity B is an impurity of Pivmecillinam, which is an orally active prodrug of the broad-spectrum penicillin antibiotic Mecillinam. Synonyms: Pivmecillinam Impurity B; [2R-[2α(S*),4β]]-4-[[(2,2-Dimethyl-1-oxopropoxy)methoxy]carbonyl]-α-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-5,5-dimethyl-2-thiazolidineacetic Acid; 2-Thiazolidineacetic acid, 4-[[(2,2-dimethyl-1-oxopropoxy)methoxy]carbonyl]-α-[[(hexahydro-1H-azepin-1-yl)methylene]amino]-5,5-dimethyl-, [2R-[2α(S*),4β]]-. CAS No. 72584-25-9. Molecular formula: C21H35N3O6S. Mole weight: 457.58.
(2'R)-2'-deoxy-2'-fluoro-2'-C-methyluridine
PSI-6206 is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. Synonyms: RO-2433; RO 2433; RO2433; PSI6206; PSI 6206; PSI-6206; GS331007; GS-331007; GS 331007; 2'-Deoxy-2'-fluoro-2'-C-methyluridine; Sofosbuvir Metabolite GS331007; 1-((2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grades: ≥95%. CAS No. 863329-66-2. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
(2R)-(2R)-2-(4-Hydroxyphenyl)glycyl-(2R)-2-[(2S,4S)-4-carboxy-5,5-dimethyl-2-thiazolidinyl]glycyl-(2R)-2-(4-hydroxyphenyl)glycyl-2-[(2S,4S)-4-carboxy-5,5-dimethyl-2-thiazolidinyl]-glycine is an intermediate in the synthesis of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: (2S,4S)-2-[(1R)-1-{[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino}-2-{[(1R)-2-({(R)-carboxy[(2S,4S)-4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl]methyl}amino)-1-(4-hydroxyphenyl)-2-oxoethyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid; 2-Thiazolidineacetic acid, α-[[(2R)-2-[[(2R)-2-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-2-[(2S,4S)-4-carboxy-5,5-dimethyl-2-thiazolidinyl]acetyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-4-carboxy-5,5-dimethyl-, (αR,2S,4S)-. Grades: 98%. CAS No. 297175-63-4. Molecular formula: C32H40N6O11S2. Mole weight: 748.82.
(2R,3R,11bR)-Dihydrotetrabenazine D-Val
(2R,3R,11bR)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2R,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. CAS No. 1025504-59-9. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2R,3R,11bS)-Dihydrotetrabenazine
(2R,3R,11bS)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: Tetrabenazine Related Impurity 8 (2R,3R,11bS); (2R,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bhexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol. Grades: 98%. CAS No. 862377-29-5. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2R,3R,11bS)-Dihydrotetrabenazine D-Val
(2R,3R,11bS)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2R,3R,11bS)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2R,3R,11bS)-Dihydrotetrabenazine L-Val
(2R,3R,11bS)-Dihydrotetrabenazine L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2R,3R,11bS)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2R,3R)-2-benzhydryl-N-benzylquinuclidin-3-amine-(D)-10-camphorsulfonate is an impurity of Maropitant. Maropitant is a neurokinin (NK1) receptor antagonist. Synonyms: Maropitant Impurity 1. Grades: 99% by HPLC. CAS No. 2243127-08-2. Molecular formula: C37H46N2O4S. Mole weight: 614.85.
(2R,3R,4R,5R)-2-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-5-(hydroxyl methyl)tetrahydrofuran-3,4-diyl diacetate is an impurity of 5-Azacytidine, an antiproliferative/cytotoxic agent for leukemia therapy. Synonyms: (2R,3R,4R,5R)-2-(4-Amino-2-oxo-1,3,5-triazin-1(2H)-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl diacetate; 1415316-72-1. CAS No. 1415316-72-1. Molecular formula: C12H16N4O7. Mole weight: 328.28.
(2R,3R,4R,5R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 2271248-78-1. Molecular formula: C21H25ClO6. Mole weight: 408.88.
(2R,3R,4R,5S,6R)-2-(4-chloro-3-(4-(((R)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. CAS No. 2452301-42-5. Molecular formula: C23H27ClO7. Mole weight: 450.91.
(2R,3R,4R,5S,6R)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate is an impurity of Empagliflozin, a medication indicated for type 2 diabetes treatment. CAS No. 1620758-27-1. Molecular formula: C31H35ClO11. Mole weight: 619.06.
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(2-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). CAS No. 2040305-09-5. Molecular formula: C29H33ClO10. Mole weight: 577.02.
2R,3R-Docetaxel
2R,3R-Docetaxel is an impurity of Docetaxel, which is a semisynthetic derivative of Paclitaxel used to treat a variety of cancers, including breast, head and neck, stomach, prostate, and non-small cell lung cancer. Synonyms: 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete Benzenepropanoic Acid Derivative; R-Erythro-taxotere; 3'-epi-docetaxel; 3'(S)-Docetaxel; Paclitaxel Impurity 62; Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βR)-; Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα, 4β, 4aβ, 6β, 9α(αR*, βR*), 11α, 12α, 12aα, 12bα]]-. Grades: ≥90%. CAS No. 133577-32-9. Molecular formula: C43H53NO14. Mole weight: 807.88.
(2R,3S,11bR)-Dihydrotetrabenazine
(2R,3S,11bR)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3S,11bR)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol; Tetrabenazine Related Impurity 11 (2R,3S,11bR); (2R,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bhexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol. Grades: 98%. CAS No. 862377-31-9. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2R,3S,11bR)-Dihydrotetrabenazine D-Val
(2R,3S,11bR)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. CAS No. 2470279-15-1. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2R,3S,11bR)-Dihydrotetrabenazine-L-Val
(2R,3S,11bR)-Dihydrotetrabenazine-L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2R,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2R,3S,11bS)-Dihydrotetrabenazine
(2R,3S,11bS)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3S,11bS)-1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-ol; (2R,3S,11bS)-DHTBZ; (2R,3S,11bS)-3-Isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol; cis(2,3)-Dihydro Tetrabenazine; Tetrabenazine Related Impurity 7 (2R,3S,11bS). Grades: 98%. CAS No. 924854-62-6. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2R,3S,11bS)-Dihydrotetrabenazine L-Val
(2R,3S,11bS)-Dihydrotetrabenazine L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2R,3S,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2R,3S,11bS)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
((2R,3S,5S)-5-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl 4-chlorobenzoate is an impurity of Decitabine, which is a potent inhibitor of DNA methylation. Molecular formula: C15H15ClN4O5. Mole weight: 366.76.
(2R,3'S)-Glycopyrrolate Bromide
(2R,3'S)-Glycopyrrolate Bromide is an impurity of Glycopyrrolate, which is an anticholinergic agent with antispasmodic activity used to treat gastrointestinal conditions associated. Synonyms: (3S)-3-[[(2R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl]oxy]-1,1-dimethylpyrrolidinium Bromide (1:1); Pyrrolidinium, 3-[ (cyclopentylhydroxyphenylacetyl)oxy]-1, 1-dimethyl-, Bromide (1:1); (S)-3-((R)-2-Cyclopentyl-2-hydroxy-2-phenylacetoxy)-1,1-dimethylpyrrolidin-1-ium bromide; Glycopyrronium Bromide EP Impurity N; Glycopyrrolate Erythro Isomer (RS-Isomer). CAS No. 129784-12-9. Molecular formula: C19H28NO3.Br. Mole weight: 398.33.
(2R,3S)-N-Benzoyl-3-phenyl Isoserine Methyl Ester
Methyl (2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoate is an intermediate in the preparation of potent anticancer drug Paclitaxel. Synonyms: (2R,3S)-Methyl 3-Benzoylamino-2-hydroxy-3-phenylpropanoate; LKT-T 0104; Methyl(-)-(2R,3S)-3-Benzoylamino-2-hydroxy-3-phenylpropionate; Methyl (2R,3S)-N-Benzoylphenylisoserinate; [R-(R*,S*)]-β-(benzoylamino)-α-hydroxybenzenepropanoic Acid Methyl Ester; (αR,βS)-β-(Benzoylamino)-α-hydroxybenzenepropanoic Acid Methyl Ester; Bz-RS-iSer(3-Ph)-OMe; (2R,3S)-N-tert-butoxycarbony-3-phenylisoserine methyl ester. Grades: 97%. CAS No. 32981-85-4. Molecular formula: C17H17NO4. Mole weight: 299.32.
(2R, 4R) -2-[[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]methyl]-4-hydroxy-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Lincomycin, which is a lincosamide antibiotic from the actinomycete Streptomyces lincolnensis. Synonyms: 2-Methyl-2-propanyl (2R,4R)-2-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-4-hydroxy-1-pyrrolidinecarboxylate; 1-Pyrrolidinecarboxylic acid, 2-[[[ (1, 1-dimethylethyl) dimethylsilyl]oxy]methyl]-4-hydroxy-, 1,1-dimethylethyl ester, (2R,4R)-. Grades: ≥95%. CAS No. 216062-16-7. Molecular formula: C16H33NO4Si. Mole weight: 331.52.
(2R,4R)-2-(Hydroxymethyl)-4-propyl-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in the synthesis of Lincomycin, which is a lincosamide antibiotic from the actinomycete Streptomyces lincolnensis. Synonyms: 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-propyl-, 1,1-dimethylethyl ester, (2R,4R)-; 2-Methyl-2-propanyl (2R,4R)-2-(hydroxymethyl)-4-propyl-1-pyrrolidinecarboxylate. CAS No. 1432589-42-8. Molecular formula: C13H25NO3. Mole weight: 243.34.
(2R,4R)-4-methyl-1-(N2-((3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonyl)-Nw-nitro-L-arginyl)piperidine-2-carboxylic acid is an impurity of Argatroban, a synthetic thrombin inhibitor and antithrombotic agent. Synonyms: Argatroban Impurity F. CAS No. 1448301-07-2. Molecular formula: C23H35N7O7S. Mole weight: 553.63.
(2R,4R)-4-Propyl-1,2-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester is an intermediate in the synthesis of Lincomycin, which is a lincosamide antibiotic from the actinomycete Streptomyces lincolnensis. Synonyms: (2R,4R)-1-(tert-butoxycarbonyl)-4-propylpyrrolidine-2-carboxylic acid; 1,2-Pyrrolidinedicarboxylic acid, 4-propyl-, 1-(1,1-dimethylethyl) ester, (2R,4R)-; (4R)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-4-propyl-D-proline. Molecular formula: C13H23NO4. Mole weight: 257.33.
(2R,4'R,8'S)-α-Tocopherol
(2R,4'R,8'S)-α-Tocopherol is one of the 8 stereoisomers contained in the racemic mixture of synthetic α-Tocopherol, a vitamin E substitute. Synonyms: (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol; (R,R,S)-alpha-Tocopherol; (2R)-2,5,7,8-Tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-6-chromanol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8S)-4,8,12-trimethyltridecyl]-, (2R)-. Grades: >98%. CAS No. 78656-12-9. Molecular formula: C29H50O2. Mole weight: 430.70.
(2R,4S)-2-[(2S,5S)-5-(4-Hydroxyphenyl)-3,6-dioxo-2-piperazinyl]-5,5-dimethyl-4-thiazolidinecarboxylic Acid is an impurity of Amoxicillin, which is an antibiotic used to treat a number of bacterial infections including middle ear infections, strep throat, pneumonia, skin infections, and urinary tract infections. Synonyms: (2R,4S)-2-[(2S,5S)-5-(4-hydroxyphenyl)-3,6-dioxopiperazin-2-yl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid; 4-Thiazolidinecarboxylic acid, 2-[(2S,5S)-5-(4-hydroxyphenyl)-3,6-dioxo-2-piperazinyl]-5,5-dimethyl-, (2R,4S)-. Molecular formula: C16H19N3O5S. Mole weight: 365.40.
(2R,4S)-2-(Hydroxymethyl)-4-propyl-1-pyrrolidinecarboxylic Acid 1,1-dimethylethyl Ester is an impurity in the synthesis of Lincomycin, which is a lincosamide antibiotic from the actinomycete Streptomyces lincolnensis. Synonyms: 1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-4-propyl-, 1,1-dimethylethyl ester, (2S,4S)-; 2-Methyl-2-propanyl (2R,4S)-2-(hydroxymethyl)-4-propyl-1-pyrrolidinecarboxylate. Molecular formula: C13H25NO3. Mole weight: 243.34.
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: (2R,4S)-5-(4-Biphenylyl)-4-(2,5-dioxo-1-pyrrolidinyl)-2-methylpentanoic acid. CAS No. 1639970-62-9. Molecular formula: C22H23NO4. Mole weight: 365.422.
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: Sacubitril impurity 16; Valsartan Impurity; (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid. CAS No. 149709-49-9. Molecular formula: C24H29NO5. Mole weight: 411.49.
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: Ethyl (2R,4S)-4-amino-5-(4-biphenylyl)-2-methylpentanoate hydrochloride; (αR,γS)-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride. CAS No. 149690-12-0. Molecular formula: C20H26ClNO2. Mole weight: 347.88.
An impurity of Sacubitril, a neprilysin inhibitor that is used in combination with valsartan to treat high blood pressure. Synonyms: 1038924-71-8; (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride(2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid;hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride; SCHEMBL597864. CAS No. 1038924-71-8. Molecular formula: C18H22ClNO2. Mole weight: 319.8.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Synonyms: 1012341-50-2; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid(2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid; FJ7AWX8DMFUNII-FJ7AWX8DMF. CAS No. 1012341-50-2. Molecular formula: C23H29NO4. Mole weight: 383.488.
(2R,4'S,8'R)-α-Tocopherol
(2R,4'S,8'R)-α-Tocopherol is one of the 8 stereoisomers contained in the racemic mixture of synthetic α-Tocopherol, a vitamin E substitute. Synonyms: (2R)-2,5,7,8-tetramethyl-2-[(4S,8R)-4,8,12-trimethyltridecyl]-6-chromanol; (R,S,R)-Alpha-Tocopherol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4S,8R)-4,8,12-trimethyltridecyl]-, (2R)-; (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4S,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol. CAS No. 78656-13-0. Molecular formula: C29H50O2. Mole weight: 430.70.
(2R,4'S,8'S)-α-Tocopherol
(2R,4'S,8'S)-α-Tocopherol is one of the 8 stereoisomers contained in the racemic mixture of synthetic α-Tocopherol, a vitamin E substitute. Synonyms: (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol; (2R)-2,5,7,8-Tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-6-chromanol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4S,8S)-4,8,12-trimethyltridecyl]-, (2R)-; (R,S,S)-Alpha-Tocopherol. CAS No. 77171-98-3. Molecular formula: C29H50O2. Mole weight: 430.70.
(2R)-5-Methoxy-1,3-oxathiolane-2-methanol
(2R)-5-Methoxy-1,3-oxathiolane-2-methanol is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: 1,3-Oxathiolane-2-methanol, 5-methoxy-, (2R)-. Grades: ≥95%. CAS No. 528567-32-0. Molecular formula: C5H10O3S. Mole weight: 150.20.
(2R)-5-Methoxy-1,3-oxathiolane-2-methanol 2-Benzoate is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (2R)-5-Methoxy-1,3-oxathiolane-2-methanol Benzoate; 1,3-Oxathiolane-2-methanol, 5-methoxy-, 2-benzoate, (2R)-. Grades: ≥95%. CAS No. 528567-33-1. Molecular formula: C12H14O4S. Mole weight: 254.30.
(2R,5R)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-((3-Fluoro-6-hydroxypyridin-2-yl)amino)-1,3-oxathiolane-2-carboxylate is an impurity of Emtricitabine, which is a nucleoside reverse transcriptase inhibitor for the treatment of HIV infection in adults and children. Molecular formula: C19H27FN2O4S. Mole weight: 398.49.
An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: Avibactam Impurity 39. Grades: ≥95%. CAS No. 2089462-91-7. Molecular formula: C15H22N2O3. Mole weight: 278.35.
(2R,5S)-5-(3,4-Dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic Acid (1R,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl Ester is an intermediate in the synthesis of Lamivudine, which is a potent nucleoside analog reverse transcriptase inhibitor, used for the treatment of chronic HBV and HIV/AIDS. Synonyms: Lamivudine Impurity 27; 1,3-Oxathiolane-2-carboxylic acid, 5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5S)-. Grades: ≥95%. CAS No. 389128-28-3. Molecular formula: C18H26N2O5S. Mole weight: 382.47.
An impurity of Avibactam, a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases. Synonyms: (1S,2R,5S)-6-Benzyloxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide; Avibactam Impurity 19. Grades: ≥95%. CAS No. 1383814-72-9. Molecular formula: C14H17N3O3. Mole weight: 275.30.
(2R)-N-(2-Benzoyl-4-chlorophenyl)-1-(phenylmethyl)-2-pyrrolidinecarboxamide Hydrochloride is one of Diazepam metabolites. Diazepam is a benzodiazepine used as an anti-anxiety and muscle relaxant, as well as to treat epilepsy. Synonyms: 2-Pyrrolidinecarboxamide, N-(2-benzoyl-4-chlorophenyl)-1-(phenylmethyl)-, hydrochloride (1:1), (2R)-; (R)-N-(2-benzoyl-4-chlorophenyl)-1-benzylpyrrolidine-2-carboxamide hydrochloride; N-(2-Benzoyl-4-chlorophenyl)-1-benzyl-D-prolinamide hydrochloride (1:1). CAS No. 1021462-91-8. Molecular formula: C25H24Cl2N2O2. Mole weight: 455.38.
(2R-trans)-5,5-Dimethyl-2-[[(phenylacetyl)amino]methyl]-4-thiazolidinecarboxylic acid is a degradation product of Penicillin, which is a β-lactam antibiotic used as an antibacterial agent. Synonyms: D-α-Benzylpenilloic Acid; (2R,4S)-5,5-Dimethyl-2-[[(2-phenylacetyl)amino]methyl]-4-thiazolidinecarboxylic Acid; 4-Thiazolidinecarboxylic acid, 5,5-dimethyl-2-[[(2-phenylacetyl)amino]methyl]-, (2R,4S)-; Benzylpenilloic acid; Penilloic G acid; (5R,3S)-Benzyl-D-penilloic acid. Grades: 98%. CAS No. 73184-06-2. Molecular formula: C15H20N2O3S. Mole weight: 308.40.
One of the impurities of Glutathione. Glutathione (GSH) is an endogenous antioxidant which plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Synonyms: Glutathione Impurity 06. CAS No. 17297-99-3. Molecular formula: C10H17N3O8S. Mole weight: 339.32.
(2S,3R,11bR)-Dihydrotetrabenazine D-Val
(2S,3R,11bR)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2S,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2S,3R,11bR)-Dihydrotetrabenazine L-Val
(2S,3R,11bR)-Dihydrotetrabenazine L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2S,3R,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2S,3R,11bS)-Dihydrotetrabenazine
(2S,3R,11bS)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: Tetrabenazine Related Impurity 10 (2S,3R,11bS); (2S,3R,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol; (2S,3R,11bS)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol; RU 346. Grades: ≥95%. CAS No. 862377-33-1. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2S,3R,11bS)-Dihydrotetrabenazine-L-Val
(2S,3R,11bS)-Dihydrotetrabenazine-L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3R,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2S,3R,11bS)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2S,3R)-2-Amino-3-(3-(benzoyloxy)-4-hydroxyphenyl)-3-hydroxypropanoic Acid is an impurity of Droxidopa, which is a synthetic amino acid precursor used as a prodrug to the neurotransmitter norepinephrine (noradrenaline). Molecular formula: C16H15NO6. Mole weight: 317.29.
(2S,3R,4R,5S,6R)-2-(3-(4-ethoxybenzyl)phenyl)-6-(hydroxyl methyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; 2452300-89-7; Deschloro Dapagliflozin; Dapagliflozin Deschloro Impurity; CS-0011227; (1S)-1,5-Anhydro-1-C-[3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3S,4R,5R,6R)-2-{m-[(p-Ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 2452300-89-7. Molecular formula: C21H26O6. Mole weight: 374.43.
(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl) (hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl) tetrahydro-2H-pyran-3,4,5-triol is an impurity of Canagliflozin which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor and is used in the treatment of type 2 diabetes and obesity. Synonyms: Tetrahydro-2H-pyran-3,4,5-triol, (2S,3R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)(hydroxy)methyl)-4-methylphenyl)-6-(hydroxymethyl); Canagliflozin impurity 08. CAS No. 1951467-29-0. Molecular formula: C24H25FO6S. Mole weight: 460.52.
(2S,3R,4R,5S,6R)-2-(4-Bromo-2-(4-ethoxyphenethyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C22H27BrO6. Mole weight: 467.35.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((4-ethoxyphenyl)(methoxy)methyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Grades: 95%. CAS No. 1318794-28-3. Molecular formula: C22H27ClO7. Mole weight: 438.90.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-isopropoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-[4-chloro-3-(4-isopropoxybenzyl)phenyl]-D-glucitol. CAS No. 946525-39-9. Molecular formula: C22H27ClO6. Mole weight: 422.90.
(2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Synonyms: (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-methoxyphenyl)methyl]phenyl]-D-glucitol; (2S,3R,4R,5S,6R)-2-(4-Chloro-3-(4-methoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. CAS No. 333359-90-3. Molecular formula: C20H23ClO6. Mole weight: 394.85.
(2S,3R,4S,5R)-2-(4-Chloro-3-(4-ethoxybenzyl)phenyl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is an impurity of Dapagliflozin. Dapagliflozin is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2) in development for the treatment of type 2 diabetes mellitus (T2DM). Molecular formula: C20H23ClO5. Mole weight: 378.85.
An impurity of Metoprolol, a β1 selective aryloxypropanolamine andrenergic antagonist. It is used in the treatment of a variety of cardiovascular disorder. Synonyms: Metoprolol Impurity 14; Metoprolol Impurity 25. CAS No. 1809560-22-2. Molecular formula: C27H45NO13. Mole weight: 591.65.
(2S,3S,11bR)-Dihydrotetrabenazine
(2S,3S,11bR)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: RU 350; (2S,3S,11bR)-9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-ol; trans (2,3)-Dihydro Tetrabenazine; (2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11bhexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol; Tetrabenazine Related Impurity 9 (2S,3S,11bR). Grades: 98%. CAS No. 862377-27-3. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2S,3S,11bR)-Dihydrotetrabenazine D-Val
(2S,3S,11bR)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2S,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2S,3S,11bR)-Dihydrotetrabenazine L-Val
(2S,3S,11bR)-Dihydrotetrabenazine L-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3S,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl L-valinate; L-Valine (2S,3S,11bR)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.
(2S,3S,11bS)-Dihydrotetrabenazine
(2S,3S,11bS)-Dihydrotetrabenazine is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3S,11bS)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol; valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester; trans (2,3)-Dihydro Tetrabenazine. Grades: 98%. CAS No. 164104-49-8. Molecular formula: C19H29NO3. Mole weight: 319.44.
(2S,3S,11bS)-Dihydrotetrabenazine D-Val
(2S,3S,11bS)-Dihydrotetrabenazine D-Val is an impurity of Tetrabenazine, which is a VMAT inhibitor used in the treatment of hyperkinetic movement disorder. Synonyms: (2S,3S,11bS)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido(2,1-a)isoquinolin-2-yl D-valinate; D-Valine (2S,3S,11bS)-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester. Molecular formula: C24H38N2O4. Mole weight: 418.57.