BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ZIP | ZIP is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: ZIP; FLJ36473; DAPK3, active, GST tagged human; PKC Zeta Pseudosubstrate Inhibitory peptide; Protein kinase Cζ pseudosubstrate, myristoyl trifluoroacetate salt; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine. CAS No. 863987-12-6. Molecular formula: C90H154N30O17. Mole weight: 1928.37. |  |
| ZIP acetate | ZIP acetate is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1-2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH.CH3CO2H; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine acetic acid; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine acetate; Peptide ZIP acetate; z-Pseudosubstrate inhibitory peptide acetate. Grade: ≥94%. Molecular formula: C92H158N30O19. Mole weight: 1988.43. | |
| ZIP, Biotinylated | ZIP, Biotinylated is a ZIP covalently attached with a biotin. It potently binds to avidins (Kd = 4 x 10-14 M), which mediates detection of ZIP in biochemical assays. Synonyms: z-Pseudosubstrate inhibitory peptide, biotinylated. Grade: >98%. Molecular formula: C100H168N32O19S. Mole weight: 2154.69. | |
| ZIP (Scrambled) | ZIP (Scrambled) is a scrambled control peptide for ZIP. Synonyms: z-Pseudosubstrate inhibitory peptide (scrambled); myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine. Grade: >98%. CAS No. 908012-18-0. Molecular formula: C90H154N30O17. Mole weight: 1928.38. | |
| Z-LEED-FMK | Z-LEED-FMK is a cell-permeant and irreversible caspase-13 inhibitor. Synonyms: Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-FMK; Z-Leu-Glu(OMe)-Glu(OMe)-Asp(OMe)-Fluoromethylketone; methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-5-isobutyl-8,11-bis(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grade: ≥95%. Molecular formula: C32H45FN4O12. Mole weight: 696.72. | |
| Z-LEVD-FMK | Z-LEVD-FMK is a cell-permeant and irreversible caspase-4 inhibitor. Synonyms: Z-LE(OMe)VD(OMe)-FMK; Z-Leu-Glu(OMe)-Val-Asp(OMe)-Fluoromethylketone; Cbz-Leu-Glu(OMe)-Val-Asp(OMe)-CH2F; Caspase 4 inhibitor. Grade: ≥95%. CAS No. 1135688-25-3. Molecular formula: C31H45FN4O10. Mole weight: 652.72. | |
| Z-LLY-FMK | Z-LLY-FMK is a cell-permeant and irreversible calpain inhibitor that is selective for calpain II, and also exhibits inhibitory effect against cathepsin L. It was shown to suppress hepatocyte apoptosis after bile duct ligation in rat. Synonyms: Calpain Inhibitor IV; Z-Leu-Leu-Tyr-FMK; Z-Leu-Leu-Tyr-Fluoromethylketone; N-[(benzyloxy)carbonyl]-L-leucyl-N-[(1S)-3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]-L-leucinamide. Grade: ≥95%. CAS No. 133410-84-1. Molecular formula: C30H40FN3O6. Mole weight: 557.66. | |
| Z-LVG-CHN2 | Z-LVG-CHN2 is a tripeptide derivative that mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50 = 190 nM) via inhibition of SARS-COV-2 3CL pro protease. Synonyms: L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(3-diazo-2-oxopropyl)-(9CI); Z-LVG-DMK. Grade: 95%. CAS No. 119670-30-3. Molecular formula: C22H31N5O5. Mole weight: 445.51. | |
| (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate-[d5] | (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate-[d5] is the labelled analogue of (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate, which is an inhibitor of O-GlcNAcase, hexosaminidase A and hexosaminidase B. Synonyms: (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenyl-d5-carbamate; (Z)-PugNAc-d5; (1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenyl-d5-amino)carbonyl]oxy]-D-gluconimidic Acid δ-Lactone; Pugnac-d5. Grade: ≥98%. CAS No. 1331383-16-4. Molecular formula: C15H14D5N3O7. Mole weight: 358.36. | |
| Zotarolimus | Zotarolimus (INN, codenamed ABT-578) is an immunosuppressant. It is a semi-synthetic derivative of rapamycin. It was designed for use in stents with phosphorylcholine as a carrier. Coronary stents reduce early complications and improve late clinical outcomes in patients needing interventional cardiology. Synonyms: A-179578; A 179578; A179578; ABT-578; ABT578; ABT 578. Grade: >98%. CAS No. 221877-54-9. Molecular formula: C52H79N5O12. Mole weight: 966.21. | |
| Z-Phe-Ala-diazomethylketone | ZPAD is a specific inhibitor of thiol proteinases. The diazomethyl ketones Z-FA-CHN2 and Z-LVG-CHN2 inhibited cathepsin L-like cysteine proteinase B from Leishmania mexicana. Synonyms: ZPAD; Z-FA-DMK; benzyl (S)-1-((S)-4-diazo-3-oxobutan-2-ylamino)-1-oxo-3-phenylpropan-2-ylcarbamate. CAS No. 71732-53-1. Molecular formula: C21H22N4O4. Mole weight: 394.42. | |
| Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone | Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone is a very effective in vivo cathepsin B inhibitor in rats. Synonyms: 2,4,6-Trimethylbenzoic acid Z-L-Phe-L-Lys-methyl ester; Z-FK-ck. Grade: 95%. CAS No. 118253-05-7. Molecular formula: C34H41N3O6. Mole weight: 587.70. | |
| Z-Phe-Tyr(tBu)-diazomethylketone | Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L with selectivity for cathepsin L over cathepsin S and cathepsin B. Synonyms: Z-Phe-Tyr(tBu)-diazomethylketone; 114014-15-2; Z-Phe-Tyr(OtertBut)-CHN.2.; Cathepsin L inhibitor III; 86-03-3; benzyl N-[(2S)-1-[[(2S)-4-diazo-1-[4-[(2-methylpropan-2-yl)oxy]phenyl]-3-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate; Cathepsin L inhibitor III?; DTXSID60415510; Z-Phe-Tyr(t-Bu)-diazomethylketone; MFCD00672349; AKOS040754808; DA-51615; HY-138208; CS-0145953; benzyl ((S)-1-(((S)-1-(4-(tert-butoxy)phenyl)-4-diazo-3-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate; Nalpha-[(benzyloxy)carbonyl]-N-[(2S)-1-(4-tert-butoxyphenyl)-4-diazo-3-oxobutan-2-yl]-L-phenylalaninamide. Grade: ≥98%. CAS No. 114014-15-2. Molecular formula: C31H34N4O5. Mole weight: 542.63. | |
| Z-VAD-FMK | Z-VAD-FMK is a broad spectrum pan-caspase inhibitor that inhibits the intracellular activation of caspase-like proteases. Synonyms: Z-VAD (OMe)-FMK; Caspase Inhibitor I. Grade: >98.0%. CAS No. 187389-52-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. | |
| Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone | Z-VAD-FMK is an irreversible tripeptide inhibitor of all caspases, useful in studies involving enzymes. Synonyms: Z-vad-FMK; N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide; benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone. CAS No. 634911-81-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a cell-permeant and irreversible caspase-2 inhibitor and can inhibits apoptosis in various cell lines. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone; L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-|A-aspartyl-L-valyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, methyl ester; Z-Val-Asp(OMe)-Val-Ala-Asp(OMe)-FMK. Grade: ≥95%. CAS No. 210344-92-6. Molecular formula: C32H46FN5O11. Mole weight: 695.74. | |
| Z-VRPR-FMK trifluoroacetate salt | Z-VRPR-FMK trifluoroacetate salt is an irreversible and cell-permeable MALT1 inhibitor. Z-VRPR-FMK dose-dependently inhibits T cell activation-induced cleavage of Bcl-10. Z-VRPR-FMK reduces NF-κB-dependent gene expression in lymphocytes. Synonyms: Z-Val-Arg-Pro-DL-Arg-FMK. Grade: >90%. Molecular formula: C31H49FN10O6.CF3CO2H. Mole weight: 790.81. | |
| Zymosan A | Zymosan A is a useful immune-potentiator adjuvant in chickens, and its co-administration with vaccine antigens enhances humoral immune responses. Zymosan A is a natural product derived from yeast cell walls, primarily composed of β-glucan, mannan, and proteins. It is commonly used in immunological research as an immune stimulant, activating macrophages and other immune cells to induce immune responses. Zymosan A is widely used in immunology research. It binds to receptors on immune cells, such as Dectin-1 and Toll-like receptors, activating macrophages, dendritic cells, and neutrophils, and inducing the release of cytokines and inflammation. It is an essential tool for studying immune system signaling and inflammation mechanisms. Uses: Anti-infective agents, local. Synonyms: Zymosans, A; A zymosans; Zymosan type A. CAS No. 58856-93-2. Molecular formula: (C6H10O5)x. | |
| Z-YVAD-FMK | Z-YVAD-FMK is a cell-permeant and irreversible caspase-1 inhibitor with anti-inflammatory activity. Synonyms: Caspase-1 Inhibitor; Z-YVAD fluoromethylketone; Z-YVAD-FMK; Caspase-1 Inhibitor VI; Z-Tyr-Val-Ala-Asp(OMe)-FMK; Z-Tyr-Val-Ala-Asp(OMe)-fluoromethyl ketone; benzyloxycarbonyl-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone; methyl (5S,8S,11S,14S)-14-(2-fluoroacetyl)-5-(4-hydroxybenzyl)-8-isopropyl-11-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grade: ≥95%. CAS No. 210344-97-1. Molecular formula: C31H39FN4O9. Mole weight: 630.67. | |
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