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Taspoglutide
Taspoglutide is a long-acting glucagon-like peptide 1 (GLP-1) receptor agonist (EC50 = 0.06 nM) under investigation for treatment of type 2 diabetes. Synonyms: (N-((N-(L-histidyl)-2-aminoisobutyryl)-L-alpha-glutamyl-glycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-valyl-L-seryl-L-seryl-L-tyrosyl-L-leucyl-L-alpha-glutamyl-glycyl-L-glutaminyl-L-alanyl-L-alanyl-L-lysyl-L-alpha-glutamyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-tryptophyl-L-leucyl-L-valyl-L-lysyl)-2-aminoisobutyryl)-L-argininamide; H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Aib-Arg-NH2. CAS No. 275371-94-3. Molecular formula: C152H232N40O45. Mole weight: 3339.71.
TAT 14
TAT 14 is an Nrf2 activator and inhibits Nrf2/Keap1 interaction with neuroprotective activity. TAT 14 has been shown to induce upregulation of Nrf2 pathway downstream gene expression including heme-oxygenase 1 and suppress LPS-induced TNF-α expression in THP-1 cells. Synonyms: TAT14; TAT-14; H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Leu-Gln-Leu-Asp-Glu-Glu-Thr-Gly-Glu-Phe-Leu-Pro-Ile-Gln-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-leucyl-L-glutaminyl-L-leucyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-threonyl-glycyl-L-alpha-glutamyl-L-phenylalanyl-L-leucyl-L-prolyl-L-isoleucyl-L-glutamine; TAT 14 Peptide (Nrf2 Activator III). Grade: ≥95%. CAS No. 1362661-34-4. Molecular formula: C137H230N48O39. Mole weight: 3173.59.
TAT-cyclo-CLLFVY
TAT-cyclo-CLLFVY has been found to be a HIF-1 dimerization inhibitor and could block protein-protein interaction of recombinant HIF-1α. Synonyms: TAT-cyclo-CLLFVY; 1446322-66-2; AKOS027470216; PD079835. Grade: ≥95% by HPLC. CAS No. 1446322-66-2. Molecular formula: C111H188N42O24S2. Mole weight: 2559.10.
TAT-Gap19
TAT-Gap19 is a brain penetrating Cx43 hemichannel blocker (IC50 ~7 μM) with no significant affinity for gap junctions or Panx1 channels. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Gln-Ile-Glu-Ile-Lys-Lys-Phe-Lys-OH; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-lysyl-L-glutaminyl-L-isoleucyl-L-alpha-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-L-lysine. Grade: 97%. CAS No. 1507930-54-2. Molecular formula: C119H212N46O26. Mole weight: 2703.28.
TAT peptide
TAT peptide, derived from the transactivator of transcription (TAT) of human immunodeficiency virus, is a cell penetrating peptide (GRKKRRQRRRPQ). Synonyms: TAT-peptide. Grade: 98%. Molecular formula: C65H124N34O15. Mole weight: 1621.91.
Tazobactam acid is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as the sodium salt. It is derived from the penicillin nucleus and is a penicillinic acid sulfone. It is used with β-lactam antibiotics to enhance their effect. It has antibacterial activity. Uses: Anti-bacterial agents. Synonyms: Tazobactam acid; Tazobactamum; Zosyn; CL-298741; YTR-830H. Grade: >98%. CAS No. 89786-04-9. Molecular formula: C10H12N4O5S. Mole weight: 300.29.
tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu
A 18-carbon fatty acid side chain of semaglutide. The affinity of the semaglutide side chain for albumin was enhanced 5-6 times. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog with significant hypoglycemic efficacy. Synonyms: Semaglutide Side Chain; Fmoc-L-Lys[OctotBu)-Glu-(otBu)-AEEA-AEEA]-OHu; (S)-22-(Tert-butoxycarbonyl)-10,19,24-trioxo-3,6,12,15-tetraoxa-9,18,23-triazahentetracontane-1,41-dioic acid; (S)-22-(tert-butoxycarbonyl)-43,43-dimethyl-10,19,24,41-tetraoxo-3,6,12,15,42-pentaoxa-9,18,23-triazatetratetracontanoic acid. Grade: ≥98%. CAS No. 1118767-16-0. Molecular formula: C43H79N3O13. Mole weight: 846.11.
TC14012
TC 14012 is an antagonist of CXCR4. Synonyms: TC 14012; 368874-34-4; TC 14012 (trifluoroacetate salt); TC14012; H-Arg-Arg-2Nal-Cys(1)-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys(1)-Arg-NH2; DA-67984; G14057; H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DCit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2. Grade: >95%. CAS No. 368874-34-4. Molecular formula: C18H28O5. Mole weight: 324.4.
TCO-PEG4-biotin is a polyethylene glycol (PEG)-based PROTAC linker. TCO-PEG4-biotin can be used in the synthesis of a series of PROTACs. Grade: 95%. CAS No. 2183440-30-2. Molecular formula: C29H50N4O8S. Mole weight: 614.79.
tcY-NH2 TFA
tcY-NH2 TFA is a selective PAR4 antagonist peptide, and it inhibits thrombin- and AY-NH2-induced rat platelet aggregation. Synonyms: N-trans-cinnamoyl-L-tyrosyl-L-prolyl-glycyl-L-lysyl-L-phenylalaninamide trifluoroacetic acid; (trans-Cinnamoyl)-YPGKF-NH2 TFA; L-Phenylalaninamide, N-[(2E)-1-oxo-3-phenyl-2-propenyl]-L-tyrosyl-L-prolylglycyl-L-lysyl-, trifluoroacetate; N-[(2E)-1-Oxo-3-phenyl-2-propen-1-yl]-L-tyrosyl-L-prolylglycyl-L-lysyl-L-phenylalaninamide trifluoroacetate. Grade: 99%. CAS No. 1262750-73-1. Molecular formula: C42H50F3N7O9. Mole weight: 853.88.
TDFA
TDFA is a protein arginine deiminase 4 (PAD4) inhibitor (IC50 = 2.3, 8.5, 26 and 71 μM for PAD4, PAD1, PAD3 and PAD2, respectively) used for the treatment of autoimmune disorders. Synonyms: (3S)-3-[[(2S,3R)-2-acetamido-3-hydroxybutanoyl]amino]-4-[[(2S)-1-amino-5-[(1-amino-2-fluoroethylidene)amino]-1-oxopentan-2-yl]amino]-4-oxobutanoic acid. CAS No. 1345019-64-8. Molecular formula: C17H29FN6O7. Mole weight: 448.45.
Teduglutide
Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue that made of 33 amino acid. Teduglutide differs from GLP-2 by an amino acid (an alanine is replaced with a glycine). Teduglutide is superior to GLP-2 on its longer acting. It was approved by FDA named Gattex® on December 21, 2012 as an orphan drug for the treatment of short bowel syndrome (SBS). Uses: A glucagon-like peptide-2 (glp-2) analogue for the treatment of short bowel syndrome(sbs). Synonyms: Teduglutide; Gattex; (Gly2)GLP-2; ALX-0600; Gly(2)-GLP-2; ALX 0600; ALX0600. Grade: 98%. CAS No. 197922-42-2. Molecular formula: C164H252N44O55S. Mole weight: 3752.07.
Teichomycin A2
Teichomycin A2 is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria. Uses: Anti-bacterial agents. Synonyms: Teicoplanin A2; Teichomycin A2; MDL-507; Targocid; Targosid. Grade: 95%. CAS No. 61036-64-4. Molecular formula: C90H99Cl2N9O34. Mole weight: 1921.70.
Teichomycin A2-5
Teichomycin A2-5 is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria. Synonyms: 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(9-methyl-1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone. Grade: >98% by HPLC. CAS No. 91032-38-1. Molecular formula: C89H99Cl2N9O33. Mole weight: 1893.68.
Teicoplanin
Teichomycin is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria. Uses: Anti-bacterial agents. Synonyms: Targocid; Teichomycin; Teichomycin A2; Teicoplanin. Grade: Assay: 900 IU/mg (anhydrous and sodium-free substance). CAS No. 61036-62-2. Molecular formula: C88H97Cl2N9O33. Mole weight: 1879.65.
Teicoplanin A2-1
Teicoplanin A2-1 is a glycopeptide antibiotic produced by Actinoplanes teichomyceticus nov. sp. (ATTCC 31121). Activity against gram-positive bacteria. Synonyms: 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[[(4Z)-1-oxo-4-decenyl]amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone. Grade: >98% by HPLC. CAS No. 91032-34-7. Molecular formula: C88H95Cl2N9O33. Mole weight: 1877.64.
Teicoplanin A2-2
A major analogue of the family of lipoglycopeptide antibiotics produced by actinoplanes teichomyceticus. It possesses potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis. Synonyms: 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone; MDL-507; Targocid; Teichomycin A2 factor 2; Teichomycin A2-2. Grade: >98% by HPLC. CAS No. 91032-26-7. Molecular formula: C88H97Cl2N9O33. Mole weight: 1879.66.
Teicoplanin A2-3
A major analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis. Synonyms: Teichomycin A2 factor 3; N-2-Decanoyl glucosamine teicoplanin; 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone. Grade: >98% by HPLC. CAS No. 91032-36-9. Molecular formula: C88H97Cl2N9O33. Mole weight: 1879.66.
Teicoplanin A2-4
An analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis. Synonyms: Teichomycin A2 factor 4; Teichomycin A2-4; 34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxodecyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone. Grade: >98% by HPLC. CAS No. 91032-37-0. Molecular formula: C89H99Cl2N9O33. Mole weight: 1893.68.
Teicoplanin A3-1
A minor polar analogue of a family of lipoglycopeptides produced by actinoplanes teichomyceticus. It is a glycopeptide antibiotic that possess potent broad spectrum antibacterial activity against gram-positive bacteria, including MRSA and E. Faecalis. It is the common degradation product of teicoplanins A2-1 to 5, resulting from cleavage of the lipoaminoglycoside substituents. Synonyms: Antibiotic L 17054; L 17054; r6-GlcNac, r7-Man pseudo-teicoplanin aglycone; 34-O-(2-(Acetylamino)-2-deoxy-beta-D-glucopyranosyl)-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-42-O-alpha-D-mannopyranosylristomycin A aglycone. Grade: >98% by HPLC. CAS No. 93616-27-4. Molecular formula: C72H68Cl2N8O28. Mole weight: 1564.25.
Telithromycin
Telithromycin is a semi-synthetic erythromycin derivative. It is created by substituting a ketogroup for the cladinose sugar and adding a carbamate ring in the lactone ring. An alkyl-aryl moiety is attached to this carbamate ring. Furthermore, the carbon at position 6 has been methylated, as is the case in clarithromycin, to achieve better acid-stability. It is used to treat community acquired pneumonia of mild to moderate severity. Uses: Antibacterial. Synonyms: HMR-3647; HMR 3647; HMR3647; RU-66647; RU 66647; RU66647; Ketek. Grade: >98%. CAS No. 191114-48-4. Molecular formula: C43H65N5O10. Mole weight: 812.00.
Telomycin
Telomycin is an ester peptide antibiotic produced by Str. canus C-159. It has activity against gram-positive bacteria. Synonyms: A 128-HYP, A 128-OP. Grade: >98%. CAS No. 19246-24-3. Molecular formula: C59H77N13O19. Mole weight: 1272.32.
Temocillin
Temocillin is a β-lactamase-resistant penicillin that effects against gram-negative bacteria. Synonyms: Temocillinum; BRL 17421; Negaban. CAS No. 66148-78-5. Molecular formula: C16H18N2O7S2. Mole weight: 414.45.
Temsirolimus
Temsirolimus is an mTOR inhibitor produced by Streptomyces. Temsirolimus potently inhibits mTOR kinase activity with IC50 of 1.76 μM, similar to that of rapamycin with IC50 of 1.74 μM. Synonyms: CCI779; CCI-779; CCI 779. Grade: >98%. CAS No. 162635-04-3. Molecular formula: C56H87NO16. Mole weight: 1030.29.
Tenuazonic acid
Tenuazonic acid is a nitrogen-containing heterocyclic antibiotic produced by Alternaria tenuis Auct 430 and Asp. sp. 1404. It has inhibitory effect on enterovirus, respiratory virus, vaccinia virus and herpes simplex virus. It can inhibit KB cells and amoeba in dysentery. Synonyms: 3-acetyl-5-(butan-2-yl)-4-hydroxy-2,5-dihydro-1H-pyrrol-2-one. Grade: >98%. CAS No. 610-88-8. Molecular formula: C10H15NO3. Mole weight: 197.23.
Teprotide
Teprotide, a nonapeptide isolated from the snake Bothrops jararaca, is an angiotensin converting enzyme (ACE) inhibitor that inhibits the conversion of angiotensin I to angiotensin II and may potentiate some of the pharmacological actions of bradykinin. It used as an antihypertension agent. Synonyms: SQ20881; H-Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro-OH; L-pyroglutamyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline; Teprotide; Bradykinin Potentiating Peptide 9a; BPP 9a; 5-Oxo-L-prolyl-L-tryptophyl-L-prolyl-L-arginyl-L-prolyl-L-glutaminyl-L-isoleucyl-L-prolyl-L-proline; Angiotensin Converting Enzyme Inhibitor. Grade: ≥95%. CAS No. 35115-60-7. Molecular formula: C53H76N14O12. Mole weight: 1101.26.
Teriparatide acetate hydrate
Teriparatide is a polypeptide and recombinant DNA form of parathyroid hormone consisting of 34 amino acids. It was approved by FDA for the treatment of certain types of osteoporosis. It also has a therapeutic activity for fragility fractures. Uses: The treatment of osteoporosis. Synonyms: L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate, hydrate (1:x:x); L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt), hydrate; Teribone; H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH.CH3CO2H.H2O. Grade: 95%. CAS No. 99294-94-7. Molecular formula: C181H291N55O51S2.C2H4O2.xH2O. Mole weight: 4177.83 (anhydrous basis).
Terlipressin
Terlipressin is an analog of vasopressin and a partial agonist of the vasopressin V1A receptor (Ki = 0.85 μM). It has been used as a vasoactive drug in the management of low blood pressure. Uses: Vasoconstrictor agents. Synonyms: N-(Glycylglycylglycyl)-8-L-lysinevasopressin; N-[N-(N-Glycylglycyl)glycyl]-8-L-lysine-vasopressin; 1-Triglycyl-8-lysine vasopressin; [N-α-Triglycyl-8-lysine]-vasopressin; Glycylpressin; Glypressin; N3-Triglycyl-8-lysine-vasopressin; Nα-Gly-Gly-Gly-8-Lys-vasopressin; Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin; Nα-Glycyl-glycyl-glycyl-lysine-vasopressin; Nα-Glycylglycylglycyl-vasopressin; Remestyp; Terlivaz; Triglycyl-8-lysine-vasopressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bridge: Cys4-Cys9); Glycyl-glycyl-glycyl-L-cysteinyl-L-tyrosyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-cysteinyl-L-prolyl-L-lysyl-glycinamide (4->9)-disulfide. Grade: ≥95%. CAS No. 14636-12-5. Molecular formula: C52H74N16O15S2. Mole weight: 1227.37.
Terpendole C
Terpendole C is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.46 μmol/L, and the CD50 that causes 50% cell damage is greater than 24.1 μmol/L. Synonyms: (3S,4aR,4bR,5aS,5bS,7aS,13bS,13cR,15aS,16aS)-1,1,13b,13c-tetramethyl-3-(2-methylprop-1-en-1-yl)-1,4a,4b,6,7,7a,8,13,13b,13c,14,15,15a,16a-tetradecahydro-5bH-[1,3]dioxino[5'',4'':2',3']oxireno[2'',3'':4',4a']chromeno[5',6':6,7]indeno[1,2-b]indol-5b-ol; (-)-terpendole C. Grade: >98%. CAS No. 156967-65-6. Molecular formula: C32H41NO5. Mole weight: 519.67.
Terrecyclic acid
Terrecyclic acid is an antibiotic produced by Asptrgillus terreus No. 14. It has weak anti-Gram-positive bacteria and fungus activity, and has an inhibitory effect on leukemia cells P388. Synonyms: Terrecyclic acid A; (+)-terrecyclic acid A. Grade: >95% by HPLC. CAS No. 83058-94-0. Molecular formula: C15H20O3. Mole weight: 248.32.
Terreic acid
Terreic acid is an antibiotic produced by Asp.terreus 5378 and Asp. parvulus. It has weak antibacterial and fungal activity. It also acts as an inhibitor of Bruton's tyrosine kinase (BTK). Synonyms: (-)-Terreic Acid. Grade: >98%. CAS No. 121-40-4. Molecular formula: C7H6O4. Mole weight: 154.12.
Terrein
Terrein is an antibiotic produced by Asp. terreus 45 and AC 100. Activity against Gram-positive bacteria. Synonyms: 4S,5R-dihydroxy-3-(1E)-1-propen-1-yl-2-cyclopenten-1-one. Grade: >98%. CAS No. 582-46-7. Molecular formula: C8H10O3. Mole weight: 154.16.
Tertiapin is a 21-amino acid peptide isolated from the venom of the honey bee (Apis mellifera). It was shown to block inward rectifier potassium channels (Kir) and calcium activated large conductance potassium channels (BK). Synonyms: H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2; L-Alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-methionyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-L-lysinamide; Tertiapin (reduced). Grade: ≥95% by HPLC. CAS No. 58694-52-3. Molecular formula: C106H180N34O23S5. Mole weight: 2459.14.
Tertiapin-Q
Tertiapin-Q, a derivative of the bee venom toxin tertiapin, is a high affinity blocker of inward-rectifier K+ channels. Tertiapin-Q binds to ROMK1 (Kir1.1) and GIRK1/4 (Kir3.1/3.4) channels (Ki = 1.3 and 13.3 nM, respectively) with selectivity over Kir2.1 channels. Synonyms: L-Lysinamide, L-alanyl-L-leucyl-L-cysteinyl-L-asparaginyl-L-cysteinyl-L-asparaginyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinylglycyl-L-lysyl-, cyclic (3→14),(5→18)-bis(disulfide); Tertiapin Q; L-alanyl-L-leucyl-L-cysteinyl-L-asparagyl-L-cysteinyl-L-asparagyl-L-arginyl-L-isoleucyl-L-isoleucyl-L-isoleucyl-L-prolyl-L-histidyl-L-glutaminyl-L-cysteinyl-L-tryptophyl-L-lysyl-L-lysyl-L-cysteinyl-glycyl-L-lysyl-L-lysinamide (3->14),(5->18)-bis(disulfide); H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Gln-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2 (Disulfide bridge: Cys3-Cys14, Cys5-Cys18). Grade: ≥95%. CAS No. 910044-56-3. Molecular formula: C106H175N35O24S4. Mole weight: 2452.01.
TetraBromoBisphenol A (2,3-Dibromopropyl)ether is a chemical compound extensively employed in the biomedical field and showcases remarkable flame-retardant characteristics. Its principal application lies in serving as a reactive flame retardant, thereby enhancing the fire safety of manifold materials. This invaluable product proficiently restrains fire propagation and finds widespread usage in diverse domains, encompassing plastics, textiles, and electronics, thereby fortifying their resistance towards fire hazards. Synonyms: 2,2-BIS[4-(2,3-DIBROMOPROPOXY)- 3,5-DIBROMOPHENYL]PROPANE; 2,2-BIS[3,5-DIBROMO-4-(2,3-DIBROMOPROPOXY)PHENYL]PROPANE; 1,1'-(Isopropylidene)bis[3,5-dibromo-4-(2,3-dibromopropoxy)benzene]; CHEMPACIFIC 34721; BISDIBROMODIBROMOPROPOXYPHENYLPROPANE; TETRABROMOBISPH. Grade: 95%. CAS No. 21850-44-2. Molecular formula: C21H20Br8O2. Mole weight: 943.62.
Tetrabromobisphenol A bismethyl ether-[13C12]
Tetrabromobisphenol A bismethyl ether-[13C12]. Synonyms: dimethyl tetrabromobisphenol A (ring-13C12). Grade: 98% by CP; 99% atom 13C. Molecular formula: C5[13C]12H16Br4O2. Mole weight: 583.84.
Tetrabromobisphenol A diallyl ether
Tetrabromobisphenol A diallyl ether is a frequently employed flame retardant within the biomedical sector and stands as a pivotal chemical compound. Its utilization predominantly revolves around augmenting the fire resistance attributes of thermoplastic materials and resins. In a myriad of applications encompassing electronics, textiles, and construction materials, this product assumes paramount importance, effectively mitigating fire hazards and bolstering safety precautions. Synonyms: 1,1'-Isopropylidenebis[4-(allyloxy)-3,5-dibromobenzene]; 2,2-BIS(4-ALLYLOXY-3,5-DIBROMOPHENYL)PROPANE; 2,2',6,6'-TETRABROMOBISPHENOL A DIALLYL ETHER; TETRABROMOBISPHENOL A DIALLYL ETHER; 1,1'-(1-methylethylidene)bis(3,5-dibromo-4-(2-propenyloxy)-benzen; 1,1'-. Grade: 98%. CAS No. 25327-89-3. Molecular formula: C21H20Br4O2. Mole weight: 624.
Tetrabromobisphenol A diglycidyl ether
Tetrabromobisphenol A diglycidyl ether (CAS# 3072-84-2 ) is a useful research chemical. Synonyms: 2,2',6,6'-Tetrabromobisphenol A diglycidyl ether; Glycidyl tetrabromodian ether. Grade: 95 %. CAS No. 3072-84-2. Molecular formula: C21H20Br4O4. Mole weight: 656.
Tetrabromobisphenol-S-[13C12]
Tetrabromobisphenol-S-[13C12].
Tetrabromobisphenol S Bis-(2,3-Dibromopropyl Ether)(TBBP-DBPE)
4-Aminobenzoic acid, also known as PABA, is a B vitamin derivative with UV absorption and antifibrotic properties. 4-Aminobenzoic acid can be generated by some intestinal bacteria, and acts as an intermediate in the synthesis of folate (vitamin B9). It is used in the treatment of fibrotic skin disorder, also can be used as a supplement for fatigue, irritability, depression, etc. Nutritional supplement in health care products. Synonyms: Benzocaine EP Impurity G; p-Aminobenzoic Acid; Bacterial Vitamin H1; p-Carboxyaniline; p-Carboxyphenylamine; Actipol; Amben; PABA; Pabacyd; Pabafilm; Trichochromogenic Factor; Vitamin BX; Vitamin H'. Grade: ≥98.5% by assay. CAS No. 150-13-0. Molecular formula: C7H7NO2. Mole weight: 137.14.
Tetracalcium diphosphorus nonaoxide
Tetracalcium diphosphorus nonaoxide, a paramount compound in biomedical industry, serves as an efficacious treatment for various bone diseases and defects including osteoporosis. Extensive research has proven its potential to induce bone regeneration and growth with considerable therapeutic implications. Its inherent structure and properties can be accessed through several chemical databases and reputable research publications, empowering the scientific community with elucidative insights. Synonyms: Tetracalcium phosphate; tetracalcium oxygen(-2) anion diphosphate; Thomas phosphate; Calcium oxide phosphate (4:1:2). Grade: 95%. CAS No. 1306-01-0. Molecular formula: Ca4O(PO4)?2. Mole weight: 366.25.
Tetrachlorobisphenol A-[ring-13C12]
A labelled analogue of Tetrachlorobisphenol A. Tetrachlorobisphenol A is classified under the family of bisphenols, which are extensively utilized in food and beverages as well as in the processing and packaging industries. Grade: 98%. Molecular formula: C3[13C]12H12Cl4O2. Mole weight: 377.98.
Tetracycline
Tetracycline is an antibiotic produced by various Streptomyces such as Str. viridifaciens BL-567201 and Str. aureofacies NRRL 2209. It has antibacterial and mycobacterial activity, and has cross-resistance with oxytetracycline and chlortetracycline. Human serum does not affect its antibacterial activity. It has the effect of inhibiting large viruses and the main gram. It is widely used in clinics to treat chlamydia, rickettsia, mycoplasma and bacterial infections. Uses: Antibiotics, tetracycline; protein synthesis inhibitors. Synonyms: Oxytetracycline EP Impurity B; (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide; Abramycin; Achromycin; (-)-Tetracycline; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-; 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, [4S-(4α,4aα,5aα,6β,12aα)]-; NSC 108579; Dispatetrin; Economycin; Biocycline; Cytome; Limecycline; Medocycline; Veracin; Oxytetracycline Dihydrate EP Impurity B; Oxytetracycline Hydrochloride EP Impurity B. Grade: >98% by HPLC. CAS No. 60-54-8. Molecular formula: C22H24N2O8. Mole weight: 444.43.
Tetracycline hydrochloride
Tetracycline hydrochloride is the hydrochloride form of tetracycline, a broad-spectrum polyketide antibiotic. It inhibits protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to bacterial ribosomes. It can be used to treat infectious diseases caused by certain Gram-positive and -negative bacteria, Rickettsia, Mycoplasma, etc. Uses: Anti-bacterial agents. Synonyms: HLS 831; HLS831; HLS-831; [4S-(4α,4aα,5aα,6β,12aα]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-Naphthacenecarboxamide Hydrochloride; (-)-Tetracycline Hydrochloride; Achromycin; Imex; Tetracyn. Grade: >98%. CAS No. 64-75-5. Molecular formula: C22H24N2O8.HCl. Mole weight: 480.90.
Tetradecaaluminum dodecacalcium tritriacontaoxide
Tetradecaaluminum dodecacalcium tritriacontaoxide. Grade: 95%. CAS No. 12005-57-1.
Tetragastrin
Tetragastrin, also known as Cholecystokinin tetrapeptide or CCK-4, is the C-terminal tetrapeptide of gastrin, consisting of the sequence L-tryptophan, L-methionine, L-aspartic acid, and L-phenylalaninamide (Trp-Met-Asp-Phe amide). It is the smallest peptide fragment of gastrin that retains the same physiological and pharmacological activity as gastrin. Tetragastrin stimulates gastric secretion and acts as a Cholecystokinin (CCK-4) receptor agonist. It is known for its gastric mucosal protective effects and is used to improve symptoms of hypochlorhydria or gastric atony, as well as in the treatment of atrophic gastritis. Tetragastrin is also recognized for its role in anxiety control and gastric acid secretion. Synonyms: Gastrin tetrapeptide; Cholecystokinin tetrapeptide; CCK-4; (S)-4-(((S)-1-Amino-1-oxo-3-phenylpropan-2-yl)amino)-3-((S)-2-((S)-2-amino-3-(1H-indol-3-yl)propanamido)-4-(methylthio)butanamido)-4-oxobutanoic acid; 4-7-Cholecystokinin-7 (swine); L-Tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide; H-Trp-Met-Asp-Phe-NH2; H-WMDF-NH2; Cholecystokinin fragment 30-33 amide; Cholecystokinin C-terminal tetrapeptide; Cholecystokinin (36-39). Grade: ≥95%. CAS No. 1947-37-1. Molecular formula: C29H36N6O6S. Mole weight: 596.71.
Tetramethyl Bisphenol A-[d6]
Tetramethyl Bisphenol A-[d6] is a labelled form of Tetramethyl Bisphenol A which is a methylated congener of Bisphenol A. Synonyms: 2,2-Bis[3,5-(dimethyl-d6)-4-hydroxyphenyl]propane; Bisxylenol A-d6; NSC 73730-d6; 2,2-Bis[4-hydroxy-3,5-(dimethyl-d6)phenyl]propane; Tetramethylbisphenol A-d6; 3,3',5,5'-Tetramethyl-4,4'-dihydroxydiphenyl-2,2-propane-d6; 4,4'-Isopropylidenebis[2,6-(dimethyl-d6)phenol]; 4,4'-Isopropylidenedi-2,6-xylenol-d6. Grade: >98%. CAS No. 203578-30-7. Molecular formula: C19H18D6O2. Mole weight: 290.43.
Tetramycin
Tetramycin is a polyene macrolide tetraene antibiotic produced by Str. noursei var. jenensis JA 3789. It has anti-fungal and protozoan activity, but its antiprotozoal activity is weak. Synonyms: Tetramycin A; 24-Demethyl-24-ethyltetrin A. Grade: >98%. CAS No. 11076-50-9. Molecular formula: C35H53NO13. Mole weight: 695.79.
Tetrazine-biotin
Tetrazine-biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Grade: ≥95%. CAS No. 1714123-51-9. Molecular formula: C19H23N7O2S. Mole weight: 413.50.
Tetrazine-diazo-PEG4-biotin
Tetrazine-diazo-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Grade: > 99%. Molecular formula: C45H57N11O9S. Mole weight: 928.07.
Tetrazine-PEG4-biotin
Tetrazine-PEG4-biotin is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Grade: >90%. Molecular formula: C30H44N8O7S. Mole weight: 660.78.
Tetrazine-SS-Biotin
Tetrazine-SS-Biotin is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Grade: >98.0%. CAS No. 2123482-78-8. Molecular formula: C24H32N8O3S3. Mole weight: 576.76.
An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: [1S-(1R*,4R*,4aR*,6aS*,7E,11E,12aS*,15S*,16aR*,20aR*,20bS*)]-4-(acetyloxy)-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,6,7,11,12a,14,15,20a-octamethyl-18H-16a,19-Metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione; 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide 9-Acetate. Grade: >99% by HPLC. CAS No. 180027-83-2. Molecular formula: C36H48O6. Mole weight: 576.76.
Tetromycin B
An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide; [1S-(1R*,4R*,4aR*,6aS*,7E,11E,12aS*,15S*,16aR*,20aR*,20bS*)]-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-Dodecahydro-4,21-trihydroxy-1,6,7,11,12a,14,15,20a-octamethyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione. Grade: >99% by HPLC. CAS No. 180027-84-3. Molecular formula: C34H46O5. Mole weight: 534.73.
TFLLR-NH2
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR amide; (Thr1)-TRAP-5 amide; (Thr1)-PAR-1 (1-5) amide (human); PAR-1-activating peptide; PAR-1-AP; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide. Grade: 98%. CAS No. 197794-83-5. Molecular formula: C31H53N9O6. Mole weight: 647.81.
TFLLR-NH2 2TFA
TFLLR-NH2 2TFA, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: H-Thr-Phe-Leu-Leu-Arg-NH2.2TFA; TFLLR-NH2.2TFA; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid; PAR-1-AP trifluoroacetate; Protease-activated receptor-1-activating peptide trifluoroacetate. Grade: ≥95%. Molecular formula: C31H53N9O6.2C2HF3O2. Mole weight: 875.87.
TFLLR-NH2(TFA)
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM. Synonyms: TFLLR-NH2 trifluoroacetate salt; L-threonyl-L-phenylalanyl-L-leucyl-L-leucyl-L-argininamide trifluoroacetic acid. Grade: 99%. CAS No. 1313730-19-6. Molecular formula: C33H54F3N9O8. Mole weight: 761.83.
TGF α (1-50) (rat) was originally identified as an agent that can reversibly confer a transformed phenotype on normal non-tumor cells, such as normal rat renal fibroblasts. This activity requires the presence of transforming growth factor-β (TGF-β), which enhances the effects of TGF-α through a separate receptor. TGF-α is synthesized by monocytes, keratinocytes and a variety of tissues and tumors. (approx. ED50 = 0.2 ng/mL). Synonyms: H-Val-Val-Ser-His-Phe-Asn-Lys-Cys-Pro-Asp-Ser-His-Thr-Gln-Tyr-Cys-Phe-His-Gly-Thr-Cys-Arg-Phe-Leu-Val-Gln-Glu-Glu-Lys-Pro-Ala-Cys-Val-Cys-His-Ser-Gly-Tyr-Val-Gly-Val-Arg-Cys-Glu-His-Ala-Asp-Leu-Leu-Ala-OH (Disulfide bridge: Cys8-Cys21, Cys16-Cys32, Cys34-Cys43); Transforming Growth Factor-α (1-50) from rat. CAS No. 89899-53-6. Molecular formula: C244H361N71O71S6. Mole weight: 5617.38.
Thailanstatin C
Thailanstatin C is an antiproliferative agent and pre-mRNA splicing inhibitor (IC50 = 6.84 μM) from Burkholderia thailandensis MSMB43. Synonyms: (1S,5R)-1,5-Anhydro-1-(carboxymethyl)-3-C-(chloromethyl)-2-deoxy-5-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-(isobutyryloxy)-2-pentenoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methyl-1,3-pentadien-1-yl}-D-erythro-pentitol; D-arabino-Heptonic acid, 3,7-anhydro-5-C-(chloromethyl)-2,4-dideoxy-7-C-[(1E,3E)-3-methyl-5-[(2S,3S,5R,6R)-tetrahydro-3,6-dimethyl-5-[[(2Z,4S)-4-(2-methyl-1-oxopropoxy)-1-oxo-2-penten-1-yl]amino]-2H-pyran-2-yl]-1,3-pentadien-1-yl]-, (7R)-. Grade: ≥95%. CAS No. 1426953-24-3. Molecular formula: C30H46ClNO9. Mole weight: 600.14.
Thailanstatin D
Thailanstatin D inhibits AR-V7 gene splicing by interfering the interaction between U2AF65 and SAP155 and preventing them from binding to polypyrimidine tract located between the branch point and the 3' splice site. Thailanstatin D exhibits a potent tumor inhibitory effect on human CRPC xenografts leading to cell apoptosis. Synonyms: Spliceostatin C. CAS No. 1609105-89-6. Molecular formula: C28H41NO8. Mole weight: 519.63.