MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| SP600125 | SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129-56-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-12041. |  |
| SPA70 | SPA70 is a potent and selective antagonist of human pregnane X receptor (hPXR), with an IC50 of 540 nM (Ki=390 nM). SPA70 can enhance the chemosensitivity of cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 931314-31-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124830. | |
| Spadin | Spadin, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with IC 50 value of 10 nM. Spadin enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin can be used for antidepressant research [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1270083-24-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1422. | |
| Spaglumic Acid | Spaglumic Acid (N-Acetylaspartylglutamic acid) is a neuropeptide found in millimolar concentrations in brain. Uses: Scientific research. Group: Natural products. Alternative Names: N-Acetylaspartylglutamic acid. CAS No. 3106-85-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100921. | |
| Spantide I | Spantide I, a substance P analog, is a selective NK 1 receptor antagonist, with K i values of 230 nM and 8150 nM for NK 1 and NK 2 receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 91224-37-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1194. | |
| Sparfloxacin | Sparfloxacin (CI-978) is a fluoroquinolone antibiotic, shows broad and potent antibacterial activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CI-978; AT-4140. CAS No. 110871-86-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0308. | |
| Sparfosic acid trisodium | Sparfosic acid trisodium is a DNA antimetabolite agent and a potent inhibitor of aspartate transcarbamoyl transferase. Aspartate transcarbamoyl transferase catalyzes the second step of de novo pyrimidine biosynthesis. Sparfosic acid trisodium synergistically enhances the cytotoxicity of a combination of 5-fluorouracil (5-FU) and interferon-alpha (IFN) against human colon cancer cell lines[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70962-66-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112732B. | |
| Sparsentan | Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K i s of 0.8 and 9.3 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RE-021; DARA-a. CAS No. 254740-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17621. | |
| Spartalizumab | Spartalizumab (PDR001) is a humanized immunoglobulin 4 monoclonal antibody that binds PD-1 with subnanomolar activity and blocks interaction with PD-L1 and PD-L2. Spartalizumab can be used for the research of anaplastic thyroid carcinoma (ATC) [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: PDR001. CAS No. 1935694-88-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9972. | |
| (-)-Sparteine | (-)-Sparteine is a natural alkaloid isolated from beans. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Lupinidine. CAS No. 90-39-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W012185. | |
| (+)-Sparteine | (+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons. Uses: Scientific research. Group: Natural products. Alternative Names: Pachycarpine. CAS No. 492-08-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W008350. | |
| Spathulenol | Spathulenol is isolated from Aristolochia yunnanensis , and has antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities. Spathulenol shows a high antioxidant activity with an IC 50 of 85.60 μg/mL in the DPPH system [1]. Uses: Scientific research. Group: Natural products. CAS No. 6750-60-3. Pack Sizes: 1 mg. Product ID: HY-N1205. | |
| Spautin-1 | Spautin-1 is a specific and potent autophagy inhibitor which inhibits ubiquitin-specific peptidases, USP10 and USP13 with IC50s of 0.6-0.7 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1262888-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12990. | |
| SPB | SPB is a agent-linker conjugate for ADC with potent anti-inflammatory activity by using Xanthotoxol, linked via the ADC linker. Uses: Scientific research. Group: Signaling pathways. CAS No. 858128-57-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104025. | |
| SPC5001 sodium | SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5?-TGmCTACAAAACmCmCA-3?[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148687A. | |
| SPC 839 | SPC 839 (compound 10) is an orally active inhibitor of AP-1 and NF-kB mediated transcriptional activation with IC50 of 0.008 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 219773-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10072. | |
| SPD304 | SPD304 is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC 50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 869998-49-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-111255. | |
| SPD304 dihydrochloride | SPD304 dihydrochloride is a selective TNF-α inhibitor, which promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. SPD304 has an IC 50 of 22 μM for inhibiting in vitro TNF receptor 1 (TNFR1) binding to TNF-α [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1049741-03-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111255A. | |
| SPDP | SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SPDP Crosslinker; Py-ds-Prp-OSu. CAS No. 68181-17-9. Pack Sizes: 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-100216. | |
| SPDV | SPDV is a cleavable ADC linker used for diagnosis and treatment of cancer or B cell proliferative diseas. Uses: Scientific research. Group: Signaling pathways. CAS No. 317331-86-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-129371. | |
| Spebrutinib | Spebrutinib (AVL-292; CC-292) is a covalent, orally active, and highly selective with an IC50 of 0.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AVL-292; CC-292. CAS No. 1202757-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18012. | |
| Spectinomycin dihydrochloride | Spectinomycin dihydrochloride is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride is also a noncompetitive inhibitor of td intron RNA with an K i value of 7.2 mM [1] - [5]. Uses: Scientific research. Group: Natural products. CAS No. 21736-83-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 25 g. Product ID: HY-B0438. | |
| Spectinomycin dihydrochloride pentahydrate | Spectinomycin dihydrochloride pentahydrate is a broad-spectrum antibiotic and inhibits the growth of a variety of gram-positive and gram-negative organisms. Spectinomycin dihydrochloride pentahydrate acts by selectively targeting to the bacterial ribosome and interrupting protein synthesis. Spectinomycin dihydrochloride pentahydrate is also a noncompetitive inhibitor of td intron RNA with an K i value of 7.2 mM [1] - [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Spectinomycin hydrochloride hydrate. CAS No. 22189-32-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B1828A. | |
| Spermidine | Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H 2 O 2 and O 2.- contents [1]. Uses: Scientific research. Group: Natural products. CAS No. 124-20-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1776. | |
| Spermidine hydrochloride | Spermidine hydrochloride maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine hydrochloride significantly decreases the H 2 O 2 and O 2.- contents [1]. Uses: Scientific research. Group: Natural products. CAS No. 334-50-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1776A. | |
| Spermine | Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 268508; Neuridine. CAS No. 71-44-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B1777. | |
| Spermine NONOate | Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 136587-13-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-101394. | |
| Spermine (Standard) | Spermine (Standard) is the analytical standard of Spermine. This product is intended for research and analytical applications. Spermine (NSC 268508) functions directly as a free radical scabenger to protect DNA from free radical attack. Spermine has antiviral effects. Uses: Scientific research. Group: Natural products. CAS No. 71-44-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-B1777R. | |
| Spermine tetrahydrochloride | Spermine tetrahydrochloride is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 306-67-2. Pack Sizes: 100 mg. Product ID: HY-B1777A. | |
| Spesolimab | Spesolimab (BI 655130) is a mouse-derived humanized IgG1k antibody against IL-36R. IL-36 plays an important role in the immune system and Spesolimab is being investigated in palmoplantar pustulosis (PPP). Spesolimab was associated with a reduction in biomarkers associated with the innate, Th1/Th17 and neutrophil pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BI 655130. CAS No. 2097104-58-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99396. | |
| Spexin | Spexin is a conserved peptide plays roles of neurotransmitter/neuromodulator and endocrine factor. Spexin peptide contains numerous aromatic amino acids and is probably amidated [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Neuropeptide Q. CAS No. 1370290-58-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1723. | |
| SPH3127 | SPH3127 (DRI 18) is a novel, highly potent, and orally active direct renin inhibitor (recombinant human-renin IC 50 =0.4 nM, human plasma renin activity IC 50 =0.45 nM). SPH3127 shows antihypertensive effect and can be used in essential hypertension research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1399849-02-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151111. | |
| SPH5030 | SPH5030 is a selective and irreversible HER2 inhibitor. SPH5030 inhibits HER2 WT and EGFR WT with IC 50 s of 3.51 and 8.13 nM, respectively. SPH5030 shows excellent activities against HER2 mutants. SPH5030 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2364326-23-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143319. | |
| S-Phenylmercapturic acid | S-Phenylmercapturic acid, a metabolite of benzene, can be used as a biomarker, identified by GC, HPLC (UV or fluorescence detection), GC-MS, LC-MS/MS or immunoassay [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4775-80-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130189. | |
| Sphinganine 1-phosphate | Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-erythro-Dihydrosphingosine 1-phosphate. CAS No. 19794-97-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113116. | |
| Sphingomyelin | Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann - Pick disease [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 85187-10-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113498. | |
| Sphingomyelins, milk | Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SMs (buttermilk). CAS No. 475662-40-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-165136. | |
| Sphingosine-1-phosphate | Sphingosine-1-phosphate (S1P) is an agonist of S1P 1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca 2+ as an extracellular ligand for G protein-coupled receptors [1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids [2]. Sphingosine-1-phosphate stimulates the DNA synthesis, cell proliferation and migration [4]. Uses: Scientific research. Group: Natural products. Alternative Names: S1P. CAS No. 26993-30-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108496. | |
| Sphingosine-1-phosphate (d17:1) | Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-erythro-Sphingosine-C17-1-phosphate. CAS No. 474923-27-8. Pack Sizes: 1 mg. Product ID: HY-141630. | |
| Sphingosine-1-phosphate-d7 | Sphingosine-1-phosphate-d 7 is the deuterium labeled Sphingosine-1-phosphate. Sphingosine-1-phosphate (S1P) is an agonist of S1P1-5 receptors and a ligand of GPR3, GPR6 and GPR12. Sphingosine-1-phosphate is an intracellular second messenger and mobilizes Ca2+ as an extracellular ligand for G protein-coupled receptors[1]. Sphingosine-1-phosphate is an important lipid mediator generated from Sphingomyelin (HY-113498) or other membrane phospholipids[2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: S1P-d7. CAS No. 2260670-15-1. Pack Sizes: 1 mg; 5 mg; 500 μg. Product ID: HY-108496S. | |
| Sphingosine (d17:1) | Sphingosine (d17:1) is a 17-carbon sphingosine found in human skin [1]. Uses: Scientific research. Group: Natural products. CAS No. 6918-48-5. Pack Sizes: 5 mg. Product ID: HY-141579. | |
| Sphingosylphosphorylcholine | Sphingosylphosphorylcholine is a bioactive sphingolipid. Sphingosylphosphorylcholine has anti-tumor activity [1]. Uses: Scientific research. Group: Natural products. CAS No. 1670-26-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-132187. | |
| SPHINX | SPHINX is a selective SRPK1 inhibitor with an IC 50 value of 0.58 μM. SPHINX effectively reduces Choroidal Neovascularization (CNV) in vivo. SPHINX can be used for the research of (age-related macular degenaration) AMD [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 848057-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132126. | |
| SPHINX31 | SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF-A165a isoform. SPHINX31 can be used to research neovascular eye disease[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1818389-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-117661. | |
| Spiclomazine | Spiclomazine (Clospirazine) is a potent mutant KRAS (G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Clospirazine. CAS No. 24527-27-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154313. | |
| Spinacine | Spinacine is an endogenous metabolite. Uses: Scientific research. Group: Natural products. Alternative Names: (S)-Spinacine. CAS No. 59981-63-4. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W067716. | |
| Spinorphin TFA | Spinorphin TFA is an inhibitor of enkephalin-degrading enzymes. Spinorphin inhibits aminopeptidase, dipeptidyl aminopeptidase III, angiotensin-converting enzyme and enkephalinase. Spinorphin possesses an antinociceptive effect [1]. Uses: Scientific research. Group: Peptides. Alternative Names: LVV-hemorphin-4 TFA. CAS No. 2828433-21-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1044A. | |
| Spinosad | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete ( Saccharopolyspora spinosa ), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. Spinosad has an excellent environmental and mammalian toxicological profile. Larvicidal activity [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 168316-95-8. Pack Sizes: 100 mg; 500 mg. Product ID: HY-138800. | |
| Spinosin | Spinosyn is a kind of effective C-saccharide, which has a protective effect. Spinosyn is active through Nrf2/HO-1 pathway inhibition Aβ 1-42 's production and combination [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 72063-39-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0651. | |
| Spinosyn D | Spinosyn D is one of the major components of Spinosad (HY-138800). Spinosad is a natural pesticide that shows biological activity against a range of insects including Lepidoptera [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131929-63-0. Pack Sizes: 1 mg. Product ID: HY-125326. | |
| Spiperone | Spiperone (Spiroperidol) is a potent dopamine D2 , serotonin 5-HT 1A , and serotonin 5-HT 2A antagonist. Spiperone is also a labelled ligand for neuroleptic receptors. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. Spiperone has the potential for the research of neurology diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Spiroperidol. CAS No. 749-02-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1371. | |
| Spiperone hydrochloride | Spiperone hydrochloride (Spiroperidol hydrochloride) is a selective dopamine D 2 receptor ( K i values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D 2 , D 3 , D 4 , D 1 and D 5 receptors, respectively) and 5-HT 2A /5-HT 1A receptor ( K i s of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Spiroperidol hydrochloride. CAS No. 2022-29-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B1371A. | |
| Spiradoline mesylate | Spiradoline mesylate (U-62066 mesylate), an arylacetamide, is a selective kappa opioid receptor (KOR) agonist with a K i of 8.6 nM in guinea pig. The K i values of Spiradoline mesylate for μ and δ receptors are 252 nM and 9400 nM, respectively. Spiradoline mesylate has potent diuretic, analgesic, antiarrythmic, antitussive, neuroprotective properties and easily penetrates the blood-brain barrier [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: U-62066 mesylate. CAS No. 87173-97-5. Pack Sizes: 1 mg. Product ID: HY-124959. | |
| Spiramycin | Spiramycin (Rovamycin) is a macrolide antibiotic produced by Streptomyces ambofaciens with against bacteria and Toxoplasma gondii activities, and also has antiparasitic effect. Spiramycin is composed of a 16-member lactone ring, on which three sugars (mycaminose, forosamine, and mycarose) are attached [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Rovamycin. CAS No. 8025-81-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-100593. | |
| Spiramycin I | Spiramycin I is a macrolide antibiotic and antiparasitic [1]. Uses: Scientific research. Group: Natural products. CAS No. 24916-50-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7141. | |
| Spirapril hydrochloride | Spirapril (SCH 33844) hydrochloride is a potent angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Spirapril competitively binds to ACE and prevents the conversion of angiotensin I to angiotensin II. Spirapril is an orally active proagent of Spiraprilat and can be used for the research of hypertension, congestive heart failure [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH 33844 hydrochloride. CAS No. 94841-17-5. Pack Sizes: 5 mg. Product ID: HY-A0230A. | |
| Spirodiclofen | Spirodiclofen is a broad spectrum acaricide acting via lipid biosynthesis inhibition (LBI) with no cross resistance to currently available acaricides and with additional insecticidal properties. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAJ-2740. CAS No. 148477-71-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0826. | |
| Spiromesifen | Spiromesifen (BSN 2060) is a broad-spectrum tetrachloro acid derivative acaricide. Spiromesifen reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase , and has no cross-resistance to any resistant mite or whitefly populations [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BSN 2060. CAS No. 283594-90-1. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114591. | |
| Spironolactone | Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor ( IC 50 =24 nM) and androgen receptor ( IC 50 =77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang?)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type ? diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects [1] [2] [3] [4] [5] [6] [7] [8] [9] [10]. Uses: Scientific research. Group: Natural products. Alternative Names: SC9420. CAS No. 52-01-7. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g; 5 g. Product ID: HY-B0561. | |
| Spironolactone (Standard) | Spironolactone (Standard) is the analytical standard of Spironolactone. This product is intended for research and analytical applications. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC 50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC 50 of 77 nM. Spironolactone promotes autophagy in podocytes [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC9420 (Standard). CAS No. 52-01-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0561R. | |
| Spirotetramat | Spirotetramat (BY-108330) is a pesticide, that can be used to control aphids on crops, without significant phytotoxicity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BY-108330. CAS No. 203313-25-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-120253. | |
| Spiroxamine | Spiroxamine is a fungicide that can be used to kill grapes with less residue [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 118134-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-121884. | |
| Spliceostatin A | Spliceostatin A, the FR901464 (HY-16212) methylated derivative, is a potent anti-tumor agent. Spliceostatin A inhibits splicing and promotes pre-mRNA accumulation by binding SF3B1. SF3B1 is a subcomplex of U2 small nuclear ribonucleoprotein in the spliceosome. Spliceostatin A induces Apoptosis in chronic lymphocytic leukemia (CLL) cells[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 391611-36-2. Pack Sizes: 1 mg. Product ID: HY-16466. | |
| Splitomicin | Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD + -dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC 50 of 60 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Splitomycin. CAS No. 5690-3-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100585. | |
| SPOP-IN-6b | SPOP-IN-6b is a speckle-type POZ protein (SPOP) inhibitor with an IC50 of 3.58 ?M (patent CN 107141287, SPOP-B-88)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2136270-20-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122615. | |
| SPP | SPP (N-succinimidyl 4-(2-pyridyldithio) pentanoate) is a cleavable disulfide linker, can be used to form cytotoxic compound- linker conjugate [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N-succinimidyl 4-(2-pyridyldithio) pentanoate. CAS No. 341498-08-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128926. | |
| SPQ | SPQ is being used to examine and measure membrane chloride transport mechanisms. Uses: Scientific research. Group: Fluorescent dye. CAS No. 83907-40-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-D0936. | |
| SPR206 acetate | SPR206 acetate is a polymyxin analog with antibiotic activity against Gram-negative pathogens , including multidrug-resistant (MDR) variants. SPR206 acetate has an anti-bacterial infection effect by interacting with the bacteriums outer membrane. The MIC values of SPR206 acetate against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301 are both 0.125 mg/L [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2408422-41-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-128780B. | |
| SPR719 | SPR719 (VXc-486) is an orally active gyrase B inhibitor, with bactericidal activity. SPR719 potently inhibits multiple agent-sensitive isolates and drug-resistant isolates of Mycobacterium tuberculosis , with MICs of 0.03 to 0.30 μg/ml and 0.08 to 5.48 μg/ml, respectively. SPR719 is promising for research of lung disease caused by non-tuberculous mycobacteria (NTM) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VXc-486. CAS No. 1384984-18-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12930. | |
| SPR741 acetate | SPR741 acetate (NAB741 acetate) is a cationic peptide derived from polymyxin B and is a potentiator molecule. SPR741 acetate increases the permeability of the outer membrane of Gram-negative bacteria and is used to treat severe Gram-negative bacteria infections. SPR741 acetate inhibits multidrug-resistant Gram-negative bacteria. The spectrum of activity of the antibiotic can be widened when used in combination with SPR741 acetate[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: NAB741 acetate. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1649B. | |
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