MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (S)-Propafenone | (S)-Propafenone ((S)-SA-79) is the S-enantiomer of Propafenone. (S)-Propafenone ((S)-SA-79) exerts beta-blocking action and the sodium channel-dependent antiarrhythmic class 1 activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (S)-SA-79. CAS No. 107381-32-8. Pack Sizes: 1 mg. Product ID: HY-B0432B. |  |
| S-Propargylcysteine | S-Propargylcysteine (SPRC), a structural analog of S-allyl cysteine (SAC), is a slow H 2 S-releasing compound. S-Propargylcysteine reduces Ca 2+ accumulation and inflammatory cytokines, inhibits STAT3, and elevates p53 and Bax. S-Propargylcysteine has anti-inflammatory activity and protects mice against acute pancreatitis. S-Propargylcysteine also has cardioprotective, neuroprotective acitivties [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SPRC. CAS No. 3262-64-4. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W001538. | |
| (S)-(-)-Propranolol hydrochloride | (S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log K d values of -8.16, -9.08, and -6.93 for β 1 , β 2 , and β 3 , respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4199-10-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0573A. | |
| (S)-p-SCN-Bn-DOTA | (S)-p-SCN-Bn-DOTAis a bifunctional chelator ( Bifunctional Chelator ; BFC ) and a macrocyclic DOTA derivative used for tumor pre-targeting. (S)-p-SCN-Bn-DOTA can be used for conjugation of peptides and radionuclides. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1020407-41-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156038. | |
| SQ109 | SQ109 is a potent inhibitor of the trypomastigote form of the parasite, with IC 50 for cell killing of 50±8 nM. SQ109, targets MmpL3 , is an antitubercular agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 722041. CAS No. 502487-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14989. | |
| SQ22536 | SQ22536 is an effective adenylate cyclase (AC) inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 17318-31-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100396. | |
| SQDG | SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 123036-44-2. Pack Sizes: 1 mg. Product ID: HY-143692. | |
| Squalamine | Squalamine (MSI-1256) is an aminosterol compound with broad-spectrum antiviral activity. Squalamine makes cells less conducive to certain viral replication by altering the electrostatic interactions in the inner membrane of host cells. Squalamine also has antibacterial and antitumor activities. Squalamine has broad-spectrum antibacterial activity against Gram-negative and Gram-positive bacteria, fungi and protozoa. Squalamine inhibits tumor-related angiogenesis and the growth of human breast cancer cells. Squalamine restores the function of enteric nervous system in Parkinson , s disease mouse models [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. Alternative Names: MSI-1256. CAS No. 148717-90-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-16468. | |
| Squalamine lactate | Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration. Uses: Scientific research. Group: Natural products. Alternative Names: MSI-1256F. CAS No. 320725-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-16467. | |
| Squalane | Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities [1]. Uses: Scientific research. Group: Natural products. CAS No. 111-01-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-N7113. | |
| Squalene | Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Super Squalene; trans-Squalene; AddaVax. CAS No. 111-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1214. | |
| Squalene-d6 | Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Super Squalene-d6; trans-Squalene-d6; AddaVax-d6. CAS No. 1875101-86-2. Pack Sizes: 5 mg. Product ID: HY-N1214S. | |
| Squalene (Standard) | Squalene (Standard) is the analytical standard of Squalene. This product is intended for research and analytical applications. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 111-02-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N1214R. | |
| Squarunkin A | Squarunkin A is a potent and selective UNC119-cargo interaction inhibitor, interrupting the UNC119A-myristoylated Src N-terminal peptide interaction (IC50=10 nM). Squarunkin A interferes with the activation of Src kinase in cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2101958-02-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-127002. | |
| (S)-Quinuclidin-3-amine dihydrochloride | (S)-Quinuclidin-3-amine dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: (S)-3-Aminoquinuclidine dihydrochloride. CAS No. 119904-90-4. Pack Sizes: 1 g; 5 g. Product ID: HY-I0034. | |
| SR-0813 | SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC50 and EC50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC50 and EC50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity (Kd=3.5 ?M) than ENL YEATS (Kd=30 nM). SR-0813 can be used for the research of acute leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2597186-19-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145409. | |
| SR1001 | SR1001 is a selective ROR α and ROR γt inverse agonist with K i s 172 and 111 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1335106-03-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13421. | |
| SR1078 | SR1078 is a selective agonist of retinoic acid receptor-related orphan receptor ?/? (ROR?/ROR?). SR1078 directly binds to the ligand binding domain of ROR? and ROR? and increases the transcriptional activity of these receptors, leading to stimulation of ROR?/? target gene transcription[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1246525-60-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14422. | |
| SR 11023 | SR 11023 is an orally active antagonist of PPAR γ, with the IC 50 value of 109 nM that plays an important role in diabetic research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820602-13-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160162. | |
| SR11237 | SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMS-649. CAS No. 146670-40-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107413. | |
| SR 11302 | SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 160162-42-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15870. | |
| SR12343 | SR12343, an IKK/NF-?B inhibitor, is a NF-?B essential modulator (NEMO)-binding domain (NBD) mimetic. SR12343 inhibits TNF-?- and LPS-induced NF-?B activation by blocking the interaction between IKK? and NEMO, with an IC50 of 37.02 ?M for TNF-?-mediated NF-?B activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055101-86-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123936. | |
| SR12813 | SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase , with an IC 50 value of 0.85 μM [1] [2]. SR12813 is also an efficient agonist of human pregnane X receptor ( hPXR ). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GW 485801. CAS No. 126411-39-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100793. | |
| SR 142948 | SR 142948 is an orally active and selective non-peptide neurotensin receptor ( NT ) antagonist with IC 50 s of 1.19 nM, 0.32 nM, 3.96 nM in h-NTR1-CHO cells, HT-29 cells, and adult rat brain, respectively. SR 142948 antagonizes NT-induced inositol monophosphate formation in HT-29 cells with an IC50 of 3.9 nM. SR 142948 blocks hypothermia, analgesia and steering behavior induced by NT in vivo. SR 142948 shows blood-brain permeability and can be used in study of psychiatric disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-64-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107664. | |
| SR 142948A | SR 142948A is a non-peptide neuropeptide neuropeptin ( NT ) receptor antagonist. SR 142948A is able to bind to neuropeptin receptors, especially with high affinity for NT1 and NT2 receptors. SR 142948A is mainly used to study the role of neuropeptide in the neurotransmitter system, especially the dopamine system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 184162-21-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-124767. | |
| SR144528 | SR144528 is a potent and selective CB2 receptor antagonist with a Ki of 0.6 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 192703-06-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13439. | |
| SR 16832 | SR 16832 is a dual site covalent PPARγ inhibitor that acts at orthosteric and allosteric sites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2088135-12-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112247. | |
| SR17018 | SR17018 is an mu-opioid-receptor (MOR) agonist, binding with GTPγS, with an EC 50 of 97 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2134602-45-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111454. | |
| SR-18292 | SR-18292 is a PPAR gamma coactivator-1? (PGC-1?) inhibitor, which increases PGC-1? acetylation, suppresses gluconeogenic gene expression and reduces glucose production in hepatocytes. Uses: Scientific research. Group: Signaling pathways. CAS No. 2095432-55-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101491. | |
| SR18662 | SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2505001-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-136530. | |
| SR2211 | SR2211 is a potent, selective synthetic ROR? modulator and functions as an inverse agonist, with a Ki of 105 nM and an IC50 of ~320 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359164-11-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16998. | |
| SR-3029 | SR-3029 is a potent and ATP competitive CK1? and CK1? inhibitor, with IC50s of 44 nM and 260 nM, respectively, and Kis of 97 nM for both kinases. Uses: Scientific research. Group: Signaling pathways. CAS No. 1454585-06-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100011. | |
| SR-31747 | SR-31747 is a sigma ligand with immunosuppressive and anti-inflammatory properties. SR-31747 blocks cell proliferation by inhibiting sterol isomerase [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132173-07-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13751. | |
| SR-318 | SR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 ?M for p38?, p38? and p38?/?, respectively. SR-318 potently inhibits the TNF-? release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413286-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135674. | |
| SR3335 | SR3335 (ML 176) is a selective ROR? inverse agonist that directly binds to ROR? with a Ki of 220 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML 176. CAS No. 293753-05-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14413. | |
| SR33805 | SR33805 is a potent Ca 2+ channel antagonist, with EC 50 s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively. SR33805 blocks L-type but not T-type Ca 2+ channels. SR33805 can be used for the research of acute or chronic failing hearts [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 121345-64-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136909. | |
| SR-3677 | SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1072959-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13300. | |
| SR-4370 | SR-4370 is an inhibitor of HDAC, with IC50s of 0.13 ?M, 0.58 ?M, 0.006 ?M, 2.3 ?M, and 3.4 ?M for HDAC1, HDAC2, HDAC3, HDAC8, and HDAC6, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1816294-67-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111400. | |
| SR-4835 | SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387704-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-130250. | |
| SR 49059 | SR 49059 (SR-49059) is a potent, orally active, selective vasopressin V1a antagonist with a K i vaule of 1.4 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150375-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18345. | |
| SR 57227A | SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC 50 ) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 77145-61-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-102064. | |
| SR-717 | SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 ?M and 2.2 ?M in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375421-09-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131454. | |
| SR8278 | SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC 50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254944-66-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14415. | |
| SR9009 | SR9009 is a REV-ERBα/β agonist with IC 50 s of 670 nM and 800 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-30-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16989. | |
| SR9011 | SR9011 is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1379686-29-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988. | |
| SR9011 hydrochloride | SR9011 hydrochloride is a REV-ERBα / β agonist with IC 50 s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-94-5. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16988A. | |
| SR9243 | SR9243 is a liver-X-receptor (LXR) inverse agonist that induces LXR-corepressor interaction. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613028-81-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16972. | |
| (S)-Rasagiline | (S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC 50 s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively [1]. (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TVP1022; S-PAI. CAS No. 185517-74-2. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14200. | |
| SRC-3-IN-2 | SRC-3-IN-2 (SI-12 6c)is an orally active steroid receptor coactivator 3 ( SRC-3 ) inhibitor. SRC-3-IN-2 has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3074959-44-4. Pack Sizes: 1 mg. Product ID: HY-163469. | |
| Src Inhibitor 1 | Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Src Kinase Inhibitor 1; Src-l1. CAS No. 179248-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101053. | |
| (S)-Remoxipride hydrochloride | (S)-Remoxipride ((-)-Remoxipride) hydrochloride is a selective dopamine D 2 -receptor antagonist with an IC 50 value of 1.57 μM. (S)-Remoxipride hydrochloride can be used for the research of psychotic disorder [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Remoxipride hydrochloride. CAS No. 73220-03-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101313A. | |
| SRI-011381 | SRI-011381 is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629138-41-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347. | |
| SRI-011381 hydrochloride | SRI-011381 hydrochloride is an orally active TGF-? signaling agonist, exhibits neuroprotective effects[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070014-88-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100347A. | |
| SRI-37330 | SRI-37330 is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-42-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142114. | |
| SRI-37330 hydrochloride | SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2322245-49-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-141623. | |
| SRI-41315 | SRI-41315 induces a prolonged pause at stop codons and suppresses PTCs (premature termination codons) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells, restoring CFTR (cystic fibrosis transmembrane conductance regulator) expression and function. SRI-41315 suppresses PTCs by reducing the abundance of the termination factor eRF1. SRI-41315 also potentiates aminoglycoside-mediated readthrough, leading to synergistic increases in CFTR activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613509-49-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150090. | |
| SRI-42127 | SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2727872-68-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148853. | |
| (S)-RLY-2608 | (S)-RLY-2608 is an S-enantiomer of of RLY-2608 (HY-153306). RLY-2608 is an orally active first-in-class allosteric mutant-selective inhibitor of PI3Ka with anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2733573-93-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153306A. | |
| (S)-(+)-Rolipram | (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC 50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (+)-Rolipram; (S)-Rolipram. CAS No. 85416-73-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0392. | |
| SRPIN340 | SRPIN340 is an ATP-competitive serine-arginine-rich protein kinase (SRPK) inhibitor, with a Ki of 0.89 ?M for SRPK1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SRPK inhibitor. CAS No. 218156-96-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13949. | |
| SRPKIN-1 | SRPKIN-1 is a covalent and irreversible SRPK1/2 inhibitor with IC50s of 35.6 and 98 nM, respectively. Anti-angiogenesis effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2089226-94-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-116856. | |
| (S,R,S)-AHPC | (S,R,S)-AHPC (VH032-NH2) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC 50 of 1.11 μM in Ba/F3 cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-NH2; VHL ligand 1. CAS No. 1448297-52-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-125845. | |
| (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine | (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of Smad3 but also improve the HIF-? protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2347517-69-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147025. | |
| (S,R,S)-AHPC-C3-NH2 hydrochloride | (S,R,S)-AHPC-C3-NH2 (VH032-C3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-C3-NH2 hydrochloride. CAS No. 2940858-65-9. Pack Sizes: 50 mg; 100 mg. Product ID: HY-130711B. | |
| (S,R,S)-AHPC-C5-COOH | (S,R,S)-AHPC-C5-COOH (VH032-C5-COOH) is a synthesized E3 ligase ligand-linker conjugate , contains the VH032 VHL-based ligand and a linker to form PROTAC s. VH-032 is a selective and potent inhibitor of VHL/HIF-1α interaction with a K d of 185 nM, has the potential for the study of anemia and ischemic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-C5-COOH. CAS No. 2267282-19-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136055. | |
| (S,R,S)-AHPC-Me | (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VHL ligand 2; E3 ligase Ligand 1A. CAS No. 1948273-02-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112078. | |
| (S,R,S)-AHPC monohydrochloride | (S,R,S)-AHPC (VH032-NH2; VHL ligand 1) hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VH032-NH2 monohydrochloride; VHL ligand 1 monohydrochloride. CAS No. 1448189-80-7. Pack Sizes: 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-101763A. | |
| SRT 1720 | SRT 1720 is a selective activator of human SIRT1 with an EC 1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC 1.5 s of 37 μM and > 300 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 925434-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10532. | |
| SRT 1720 dihydrochloride | SRT 1720 dihydrochloride is a selective and orally active activator of SIRT1 with an EC 50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2468639-77-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15145A. | |
| SRT 2104 | SRT 2104 is a first-in-class, highly selective and brain-permeable activator of the NAD+ dependent deacetylase Sirt1, increases Sirt1 protein, but shows no effect on Sirt1 mRNA. Used in the research of diabetes mellitus and Huntingtons disease[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093403-33-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-15262. | |
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