BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AMG232 | AMG232 is an extremely potent MDM2 inhibitor with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model (ED50 = 9.1 mg/kg). AMG232 is currently under clinical development. Synonyms: AMG-232; AMG 232. Grade: 0.98. CAS No. 1352066-68-2. Molecular formula: C28H35Cl2NO5S. Mole weight: 568.55. |  |
| AMG2850 | AMG2850 is a potent, selective and orally bioavailable antagonist of transient receptor potential melastatin 8 (TRPM8). Synonyms: (8R)-8-[4-(Trifluoromethyl)phenyl]-N-[(2S)-1,1,1-trifluoro-2-propanyl]-5,8-dihydro-1,7-naphthyridine-7(6H)-carboxamide; 1,7-Naphthyridine-7(6H)-carboxamide, 5,8-dihydro-N-[(1S)-2,2,2-trifluoro-1-methylethyl]-8-[4-(trifluoromethyl)phenyl]-, (8R)-; (R)-8-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide. Grade: ≥98%. CAS No. 1470018-52-0. Molecular formula: C19H17F6N3O. Mole weight: 417.35. | |
| AMG319 | AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. Synonyms: AMG319; AMG-319; AMG 319; ACP319; ACP-319; ACP 319. Grade: 98%. CAS No. 1608125-21-8. Molecular formula: C21H16FN7. Mole weight: 385.4. | |
| AMG 333 | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM for hTRPM8 and IC50 of 20 nM for rTRPM8, which displays high selectivity over other TRP channels (IC50>20 uM, TRPV1/V3/V4/A1). AMG-333 was well-tolerated in 28 day rat and dog preclinical safety studies and advanced to Phase 1 human clinical trials. Synonyms: 6-[[[(S)-(3-Fluoro-2-pyridinyl)[3-fluoro-4-(trifluoromethoxy)phenyl]methyl]amino]carbonyl]-3-pyridinecarboxylic acid. Grade: ≥98% by HPLC. CAS No. 1416799-28-4. Molecular formula: C20H12F5N3O4. Mole weight: 453.33. | |
| AMG-337 | AMG 337 is an orally bioavailable inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor AMG 337 selectively binds to c-Met, thereby disrupting c-Met signal transduction pathways. Synonyms: AMG337; AMG-337; AMG 337. Grade: 98%. CAS No. 1173699-31-4. Molecular formula: C23H22FN7O3. Mole weight: 463.47. | |
| AMG 369 | This active molecular is a S1P1/S1P5 agonist with limited activity at S1P3. AMG 369 has no activity at S1P2 and S1P4. AMG-369 is shown to reduce blood lymphocyte counts 24 hours postdose with dosed orally at 0.1 mg/kg. Till Jun 2016, no recent reports of development identified for preclinical development in Multiple-sclerosis in USA were published yet. Uses: Multiple sclerosis. Synonyms: AMG-369; AMG 369; AMG369; KB-74649; KB74649; KB 74649. 1-[[3-fluoro-4-[6-(1-phenylcyclopropyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]methyl]azetidine-3-carboxylicacid; ZINC216149127; 1202073-26-4. Grade: 98%. CAS No. 1202073-26-4. Molecular formula: C26H22FN3O2S. Mole weight: 459.54. | |
| AMG-3969 | AMG-3969 is a potent and selective disruptor of glucokinase-glucokinase regulatory protein interaction (GK-GKRP). AMG-3969 can modulate the blood glucose levels in rodent models of diabetes. Synonyms: 2-[4-[(2S)-4-(6-aminopyridin-3-yl)sulfonyl-2-prop-1-ynylpiperazin-1-yl]phenyl]-1,1,1,3,3,3-hexafluoropropan-2-ol. Grade: 98% by HPLC. CAS No. 1361224-53-4. Molecular formula: C21H20F6N4O3S. Mole weight: 522.466. | |
| AMG-458 | AMG 458 is a potent c-Met inhibitor with Ki of 1 nM ~ 2.0 nM. AMG-458 was found to significantly inhibit tumor growth in the NIH3T3/TPR-Met and U-87 MG xenograft models with no adverse effect on body weight. Synonyms: AMG458; AMG 458; 1-(2-Hydroxy-2-methylpropyl)-N-[5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl]-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide; 2,3-Dihydro-1-(2-hydroxy-2-methylpropyl)-N-[5-[(7-methoxy-4-quinolinyl)oxy]-2-pyridinyl]-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide. Grade: ≥98%. CAS No. 913376-83-7. Molecular formula: C30H29N5O5. Mole weight: 539.58. | |
| AMG-47a | AMG-47a is a potent inhibitor of Lck and T cell proliferation. It has anti-inflammatory activity (ED50 = 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. It displays subnanomolar inhibition against Lck, and low inhibition against other hard to inhibit kinases in several other in vitro assays. It effectively inhibits the JNK family of kinases including TYK2 at ~ 1.2 μM but well under 10 μM. It selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells. Uses: Amg-47a has anti-inflammatory activity. Synonyms: AMG-47a; AMG 47a; AMG47a; AMG-47; AMG 47; AMG47. 4-Methyl-3-[2-[[2-(4-morpholinyl)ethyl]amino]-6-quinazolinyl]-N-[3-(trifluoromethyl)phenyl]benzamide. Grade: 95%. CAS No. 882663-88-9. Molecular formula: C29H28F3N5O2. Mole weight: 535.56. | |
| AMG 487 | AMG 487 is a CXCR3 antagonist that inhibits cell migration and metastasis. Synonyms: AMG-487; AMG 487; AMG487. Benzeneacetamide, N-((1R)-1-(3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-; N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(pyridin-3-ylmethyl)-2-[4-(trifluorome. CAS No. 473719-41-4. Molecular formula: C32H28F3N5O4. Mole weight: 603.59. | |
| AMG 487 (S-enantiomer) | AMG 487 (S-enantiomer), the S-enantiomer of AMG 487, is an antagonist of the chemokine receptor CXCR3. Synonyms: N-{(1S)-1-[3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-N-(3-pyridinylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide; Benzeneacetamide, N-[(1S)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-. Grade: ≥98%. CAS No. 473720-30-8. Molecular formula: C32H28F3N5O4. Mole weight: 603.59. | |
| AMG510 | AMG-510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG 510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG 510. Synonyms: AMG 510; AMG-510; Sotorasib. Grade: ≥98%. CAS No. 2252403-56-6. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
| AMG510 racemate | AMG510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. At the 2019 World Conference on Lung Cancer (WCLC), Amgen declared the efficacy of AMG510 for treating non-small cell lung cancer (NSCLC) with KRAS G12 C-mutated solid tumors. Amgen also announced prospective directions for AMG510 through academic scholars and reports the few limitations on official drug release as evidence for potential investors to consider the value of AMG510. Uses: Immune checkpoint inhibitors. Synonyms: AMG-510 racemate; AMG 510 racemate; Sotorasib racemate. CAS No. 2296729-00-3. Molecular formula: C30H30F2N6O3. Mole weight: 560.59. | |
| AMG-517 | AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM. Synonyms: AMG-517; AMG 517; AMG517; BD-0082; BD 0082; BD0082; BAY E 9736. Grade: >98%. CAS No. 659730-32-2. Molecular formula: C20H13F3N4O2S. Mole weight: 430.4. | |
| AMG 548 | AMG-548 is a selective p38α inhibitor with Ki value of 0.5nM. It displays >1000-fold selectivity against 36 other kinases, and it can inhibit whole blood LPS-stimulated TNFα. In Sep 2008, Preclinical for Rheumatoid arthritis in USA was discontinued. Uses: Inflammation; rheumatoid arthritis. Synonyms: AMG 548; AMG-548; AMG548; UNII-PGR0H531I4; 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone. Grade: 98%. CAS No. 864249-60-5. Molecular formula: C29H27N5O. Mole weight: 461.56. | |
| AMG-548 dihydrochloride | AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki = 0.5 nM). It shows slightly selective over p38β (Ki = 36 nM) and >1000 fold selective against p38γ and p38δ. Grade: 99%. Molecular formula: C29H29Cl2N5O. Mole weight: 534.48. | |
| AMG-628 | AMG-628 is a highly selective, ATP-competitive inhibitor of Raf kinases. It can inhibit activation of tyrosine protein kinases. AMG-628 can also inhibit growth, and induce cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation. Synonyms: AMG-628; AMG 628; AMG628; UNII-28J966TN3X; CHEMBL226574; N-(4-((6-(4-(1-(4-fluorophenyl)ethyl)-1-piperazinyl)-4-pyrimidinyl)oxy)-2-benzothiazolyl)-Acetamide. Grade: 98%. CAS No. 862269-73-6. Molecular formula: C25H25FN6O2S. Mole weight: 492.57. | |
| AMG-747 | AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2. Uses: Amg-747 was used as an antipsychotic drug. Synonyms: 1-Piperazineacetic acid, 4-((R)-phenyl(3-(trifluoromethyl)phenyl)methyl)-; 2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid; Tilapertin; AMG747; AMG-747; AMG 747. Grade: >98 %. CAS No. 1000690-85-6. Molecular formula: C20H21F3N2O2. Mole weight: 378.39. | |
| AMG 837 | AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837, AMG837, AMG 837. Grade: >98%. CAS No. 865231-46-5. Molecular formula: C26H21F3O3. Mole weight: 438.44. | |
| AMG 837 calcium hydrate | AMG 837 calcium hydrate is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. Synonyms: AMG-837; AMG837; AMG 837. Grade: 0.98. CAS No. 1259389-38-2. Molecular formula: C52H42CaF6O7. Mole weight: 455.45. | |
| AMG 837 hemicalcium salt | The calcuim salt form of AMG 837, which has been found to be a GPR40 partial agonist and could probably be used as an antidiabetic agent. Synonyms: AMG 837 hemicalcium salt; AMG837 hemicalcium salt; AMG-837 hemicalcium salt; (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt. Grade: ≥98% by HPLC. CAS No. 1291087-14-3. Molecular formula: C26H20F3O3.½Ca. Mole weight: 457.47. | |
| AMG 837 sodium salt | AMG 837 sodium salt is a potent GPR40 agonist with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. It displayed the expected two-fold increase in potency on GPR4 compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40. It is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. It was a potent partial agonist in the calcium flux assay on the GPR40 receptor and potentiated glucose stimulated insulin secretion in vitro and in vivo. Synonyms: AMG-837 sodium; AMG837 sodium; AMG 837 sodium; AMG-837 sodium salt. Grade: >98%. CAS No. 865231-45-4. Molecular formula: C26H20F3NaO3. Mole weight: 460.42. | |
| AMG8380 | AMG8380 is a potent and selective of the Voltage-Gated Sodium Channel Na V 1.7. Synonyms: AMG8379; (Rac)-AMG8380. CAS No. 1642112-32-0. Molecular formula: C25H16ClF2N3O5S. Mole weight: 543.93. | |
| AMG8562 | AMG8562 is a novel vanilloid receptor TRPV1 modulator. Synonyms: AMG-8562; AMG8562; AMG 8562; (E)-N-[(2R)-2-hydroxy-2,3-dihydro-1H-inden-4-yl]-3-[2-piperidin-1-yl-4-(trifluoromethyl)phenyl]prop-2-enamide; AMG-8562; 2-Propenamide, N-((2R)-2,3-dihydro-2-hydroxy-1H-inden-4-yl)-3-(2-(1-piperidinyl)-4-(trifluoromethyl)phenyl)-, (2E)-. Grade: >98 %. CAS No. 1041478-78-7. Molecular formula: C24H25F3N2O2. Mole weight: 430.47. | |
| AMG-8718 | This active molecular is a potent BACE1 inhibitor that is a potential target for the treatment of Alzheimer's disease. AMG-8718 produced significantly reductions of CSF and brain Aβ levels in animal models. It also exhibited reduced potential for QTc elongation in a cardiovascular safety model. BACE1 inhibition has direct efficacy in the Alzheimer's disease pathology but it does not affect viability largely. Uses: The treatment of alzheimer's disease. Synonyms: AMG8718; AMG 8718; AMG-8718. (4S)-7'-(2-fluoropyridin-3-yl)-3'-[2-(3-methyloxetan-3-yl)ethynyl]spiro[5H-1,3-oxazole-4,5'-chromeno[2,3-b]pyridine]-2-amine. Grade: 98%. CAS No. 1215868-94-2. Molecular formula: C25H19FN4O3. Mole weight: 442.45. | |
| AMG-900 | AMG 900 is a small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Synonyms: AMG900; AMG-900; AMG 900. Grade: 0.98. CAS No. 945595-80-2. Molecular formula: C28H21N7OS. Mole weight: 503.57764. | |
| AMG 925 | AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor. AMG 925 inhibited AML xenograft tumor growth by 96% to 99% without significant body weight loss. The antitumor activity of AMG 925 correlated with the inhibition of STAT5 and RB phosphorylation, the pharmacodynamic markers for inhibition of FLT3 and CDK4, respectively. In addition, AMG 925 was also found to inhibit FLT3 mutants (e.g., D835Y) that are resistant to the current FLT3 inhibitors (e.g., AC220 and sorafenib). AMG 925, which combines inhibition of two kinases essential for proliferation and survival of FLT3-mutated AML cells, may improve and prolong clinical responses. Synonyms: AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925. Grade: >98%. CAS No. 1401033-86-0. Molecular formula: C26H29N7O2. Mole weight: 471.55. | |
| AMG 925 HCl | AMG 925 HCl is a potent, selective and orally available dual inhibitor of FLT3/CDK4 with IC50s of 2±1 nM and 3±1 nM, respectively. Synonyms: 2-Hydroxy-1-[2-{[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino}-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]ethanone hydrochloride (1:1); Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-, hydrochloride (1:1). Grade: ≥98%. CAS No. 1401034-19-2. Molecular formula: C26H30ClN7O2. Mole weight: 508.02. | |
| AMG-978 | AMG-978 is an inhibitor of beta-secretase 1 (BACE1) (IC50 = 27 nM) which is in the preclinical study for the treatment of Alzheimer's disease. Uses: The potential treatment of alzheimer's disease. Synonyms: AMG 978; AMG978. | |
| AMG-9810 | AMG-9810 is potent, non-vanilloid and selective TRPV1 receptor antagonist with IC50 value of 17 nM. It inhibits capsaicin-, proton-, heat- and endogenous ligand-induced activation of human and rat recombinant TRPV1 receptors. It displays antihyperalgesic properties in a rat model of inflammatory pain. It was developed by Amgen. Uses: Amg-9810 displays antihyperalgesic properties. Synonyms: AMG-9810; AMG9810; AMG 9810. (2E)-N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-propanamide; 2-PropenaMide, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-diMethylethyl)phenyl]-, (2E)-; (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)prop-2-enami. Grade: 98%. CAS No. 545395-94-6. Molecular formula: C21H23NO3. Mole weight: 337.41. | |
| Amgen-23 | Amgen-23 is a potent sphingosine kinases (SPHK) inhibitor. Grade: 98% by HPLC. CAS No. 1448706-15-7. Molecular formula: C23H25Cl2N3O2S. Mole weight: 478.4. | |
| AMG PERK 44 | AMG PERK 44 is a potent and selective PERK inhibitor with IC50 of 6 nM, which exhibits 160-fold selectivity over B-Raf, GCN2 and a panel of 387 other kinases. Synonyms: 4-[2-Amino-4-methyl-3-(2-methyl-6-quinolinyl)benzoyl]-1,2-dihydro-1-methyl-2,5-diphenyl-3H-pyrazol-3-one hydrochloride. Grade: ≥98%. CAS No. 1883548-84-2. Molecular formula: C34H28N4O2·HCl. Mole weight: 561.07. | |
| AMI-1 | AMI-1 is a cell-permeable inhibitor which inhibits protein arginine N-methyltransferase (PRMT) activity with IC50 of 8.81 μM for PRMT1 and IC50 of 3.04 μM for Hmt1p in vitro. MI-1 does not compete for the AdoMet (S-adenosyl-L-methionine; SAM) binding site and exhibits minimal effects on both SET (Sub39H1, Suv39H2, SET7) and non-SET (DOT1) lysine N-methyltransferases. Furthermore, AMI-1 prevents in vivo arginine methylation of cellular proteins and can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements, thus operating as a brake on certain hormone actions. Synonyms: 7,7'-(Carbonyldiimino)bis[4-hydroxy-2-naphthalenesulfonic acid] disodium salt; 5,5'-Dihydroxy-2,2'-dinaphthylcarbamide-7,7'-disulfonic acid disodium salt; 6,6'-Ureylenebis(1-naphthol-3-sulfonic acid) disodium salt; 7,7'-Ureylenebis(4-hydroxy-2-naphthalenesulfonic acid) disodium salt; Carbonyl J disodium salt; I Acid Urea disodium salt; N,N'-Bis(5-hydroxy-7-sulfo-2-naphthyl)urea disodium salt; N,N'-Bis(7-sulfo-5-hydroxy-2-naphthyl)urea disodium salt; N,N'-Bis[1-hydroxy-3-sulfonaphthyl(6)]urea disodium salt; N,N'-Bis[1-oxy-3-sulfonaphthyl(6)]urea disodium salt; AMI-1 sodium salt; AMI 1; AMI1; J Acid Urea disodium salt. Grade: ≥98%. CAS No. 20324-87-2. Molecular formula: C21H14N2Na2O9S2. Mole weight: 548.45. | |
| AMI-193 | AMI-193 has been found to be a selective 5-HT antagonist and could be also used as a starting reagent in some pharmaceutical synthesis. Synonyms: Spiramide; R 5808; R-5808; R5808; 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone. Grade: ≥99% by HPLC. CAS No. 510-74-7. Molecular formula: C22H26FN3O2. Mole weight: 383.46. | |
| Amicarbazone | The phenotypic responses of sensitive plants exposed to amicarbazone include chlorosis, stunted growth, tissue necrosis, and death. Its efficacy as both a foliar- and root-applied herbicide suggests that absorption and translocation of this compound is very rapid. As a result, its efficacy is susceptible to the most common form of resistance to PSII inhibitors. Nonetheless, amicarbazone has a good selectivity profile and is a more potent herbicide than atrazine, which enables its use at lower rates than those of traditional photosynthetic inhibitors. Synonyms: BAY314666; BAY-MKH 3586; BAY 314666; BAY-MKH3586. Grade: >98%. CAS No. 129909-90-6. Molecular formula: C10H19N5O2. Mole weight: 241.29. | |
| Amicarbazone Impurity 1 | An impurity of Amicarbazone. Synonyms: N-(1,1-Dimethylethyl)-2,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide. Grade: > 95%. CAS No. 889062-05-9. Molecular formula: C10H18N4O2. Mole weight: 226.28. | |
| Amicarbazone Impurity 2 | An impurity of Amicarbazone. Synonyms: N-(1,1-Dimethylethyl)-2,5-dihydro-3-(1-hydroxy-1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide. Grade: > 95%. CAS No. 889062-06-0. Molecular formula: C10H18N4O3. Mole weight: 242.28. | |
| Amidantel | Amidantel is a bio-active chemical compound. It is used as anthelmintics. Uses: Amidantel is used as anthelmintics. Synonyms: Amidantel free base; Amidantelum; 4'-((1-(Dimethylamino)ethylidene)amino)-2-methoxyacetanilide; Bay-d-8815. Grade: 98%. CAS No. 49745-00-8. Molecular formula: C13H19N3O2. Mole weight: 249.31. | |
| Amidantel hydrochloride | Amidantel is a potent anthelminthic agent. Uses: Anthelminthic. Synonyms: BAY-d 8815; N-(4-((1-(Dimethylamino)-aethyliden)amino)phenyl)-2-methoxyacetamid-hydrochlorid; 49745-00-8(free base). Grade: 98%. CAS No. 69884-15-7. Molecular formula: C13H19N3O2.ClH. Mole weight: 285.77. | |
| Amidated Pectin | Amidated pectin is a modified form of pectin, a natural plant-based polysaccharide found in fruits such as apples and citrus fruits. Amidated pectin is created by chemically modifying pectin with ammonia or other alkaline agents to introduce amide groups to the pectin molecule. Uses: Antidiarrheals. Synonyms: Pectin amide; Amid AF 005; INS 440; Pectin Amid AF 025; Pectin Amid AU-L 027/09; Pectin Amid CU 025; Pectin D. CAS No. 56645-02-4. | |
| Amidotrizoic Acid | Diatrizoic acid is a gradient reagent used for blood cell separation and diagnostic aid (radiopaque medium). Diatrizoic acid induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium. Synonyms: Diatrizoic Acid; 3,5-Diacetamido-2,4,6-triiodobenzoic Acid; 3,5-bis(Acetylamino)-2,4,6-triiodobenzoic Acid; Urografin Acid; Odiston (USP). CAS No. 117-96-4. Molecular formula: C11H9I3N2O4. Mole weight: 613.92. | |
| Amifampridine | Amifampridine is a drug, predominantly in the treatment of a number of rare muscle diseases. It is used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Neuromuscular agents. Synonyms: pyridine-3,4-diamine. Grade: > 98 %. CAS No. 54-96-6. Molecular formula: C5H7N3. Mole weight: 109.13. | |
| Amifampridine Phosphate | Amifampridine is a drug, predominantly used to treat many of the congenital myasthenic syndromes, particularly those with defects in choline acetyltransferase, downstream kinase 7, and those where any kind of defect causes "fast channel" behaviour of the acetylcholine receptor. Uses: Predominantly in the treatment of a number of rare muscle diseases. Synonyms: phosphoric acid; pyridine-3,4-diamine. Grade: ≥98%. CAS No. 446254-47-3. Molecular formula: C5H10N3O4P. Mole weight: 207.12. | |
| Amifostine | Amifostine is a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues. Uses: Radiation-protective agents. Synonyms: Ethyol; WR2721; WR 2721; WR-2721. Grade: >98%. CAS No. 20537-88-6. Molecular formula: C5H15N2O3PS. Mole weight: 214.22. | |
| Amifostine hydrate | Amifostine hydrate is a radiation-protective agent. Synonyms: Amifostinum; Amifostine monohydrate; Amifostinum; Amifostina. CAS No. 63717-27-1. Molecular formula: C5H15N2O3PS.H2O. Mole weight: 232.235. | |
| Amikacin B | Amikacin B is an impurity of Amikacin, which is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine; 1-N-[(S)-4-Amino-2-hydroxybutyryl]kanamycin B; BB-K26; Habekacin; Amikacin EP Impurity H; (2S)-4-Amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide; Butanamide, 4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-α-D-glucopyranosyl)oxy]-4-[(2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl]-2-hydroxy-, (2S)-. Grade: 95%. CAS No. 48237-20-3. Molecular formula: C22H44N6O12. Mole weight: 584.62. | |
| Amikacin B Sulfate | Amikacin B Sulfate is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[2,6-diamino-2,6-dideoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Amikacin B Sulfate; 1-N-[(S)-4-Amino-2-hydroxybutyryl]kanamycin B Amikacin B Sulfate; BB-K26 Amikacin B Sulfate; Habekacin Amikacin B Sulfate; Amikacin EP Impurity H Sulfate. Grade: 95%. Molecular formula: C22H44N6O12.xH2SO4. Mole weight: 584.62 (free base). | |
| Amikacin-d5 Sulfate | Labelled Amikacin. Semisynthetic aminoglycoside antibiotic derived from Kanamycin A. Antibacterial. Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine-d5 Sulfate; 1-N-[L-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A-d5 Sulfate; Amiglyde V-d5; Amika-d5; Amikacin-d5 Disulfate; Amikacin-d5 Sulfate; Amikavet-d5; Amikin-d5; Amiklin-d5; Antibiotic BB-K 8-d5 Sulfate; Biklin-d5; Biodacyn-d5; Biodacyna-d5; Fabianol-d5; Grasil-d5; Kaminax-d5; Mikavir-d5; Novamin-d5; Pierami-d5; Selemycin-d5. Molecular formula: C22H42D5N5O21S2. Mole weight: 786.79. | |
| Amikacin EP Impurity A | Amikacin EP Impurity A is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Molecular formula: C22H43N5O13. Mole weight: 585.60. | |
| Amikacin EP Impurity C | Amikacin EP Impurity C is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Molecular formula: C22H43N5O13. Mole weight: 585.60. | |
| Amikacin EP Impurity E | Amikacin EP Impurity E is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: 4-O-(3-amino-3-deoxy-a-D-glucopyranosyl)-6-O-[6-[[(2S)-4-amino-2-hydroxybutanoyl]amino]-6-deoxy-a-D-glucopyranosyl]-2-deoxy-L-streptamine. Molecular formula: C22H43N5O13. Mole weight: 585.60. | |
| Amikacin EP Impurity F | Amikacin EP Impurity F is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Molecular formula: C26H50N6O15. Mole weight: 686.70. | |
| Amikacin EP Impurity F Sulfate | Amikacin EP Impurity F Sulfate is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-[[(2S)-4-amino-2-hydroxy-1-oxobutyl]amino]-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Sulfate; 1,6'-Di-N-(L-4-amino-2-hydroxybutyryl) Kanamycin A Sulfate; Amikacin Impurity B Sulfate; 1,6'-Di-HABA Kanamycin A Sulfate. Grade: 95%. Molecular formula: C26H50N6O15.xH2SO4. Mole weight: 686.70 (free base). | |
| Amikacin EP Impurity G | Amikacin EP Impurity G is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Molecular formula: C22H43N5O13. Mole weight: 585.60. | |
| Amikacin EP Impurity H | Amikacin EP Impurity H is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-{[(2R,3R,5R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4-{[(2S,3R,4R,5R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide. Molecular formula: C22H44N6O12. Mole weight: 584.62. | |
| Amikacin impurity A | 3-HABA Kanamycin A is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Synonyms: (S)-4-Amino-N-((1S,2R,3S,4S,5R)-5-amino-4-(((2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-2-(((2R,3R,4S,5R,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide; 3-HABA Kanamycin A; (S)-O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N3-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine Sulfate; 3-N-[L-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N3-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine. Grade: >95%. CAS No. 50725-24-1. Molecular formula: C22H43N5O13. Mole weight: 585.60. | |
| Amikacin impurity B | An impurity of Amikacin. Amikacin is an aminoglycoside antibiotic that is known for its broad-spectrum activity against various Gram-negative bacteria, including some strains that are resistant to other aminoglycosides like gentamicin and tobramycin. Synonyms: 1,3-Di-HABA Kanamycin A; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1,N3-bis[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine; (2S,2'S)-N,N'-((1S,3R,4S,5R,6R)-4-(((2S,3R,4S,5S,6R)-4-Amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-(((2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)-5-hydroxycyclohexane-1,3-diyl)bis(4-amino-2-hydroxybutanamide). Grade: >95%. CAS No. 927821-99-6. Molecular formula: C26H50N6O15. Mole weight: 686.72. | |
| Amikacin impurity D | An impurity of Amikacin. Amikacin is an aminoglycoside antibiotic that is known for its broad-spectrum activity against various Gram-negative bacteria, including some strains that are resistant to other aminoglycosides like gentamicin and tobramycin. Synonyms: O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-streptamine; Inositol, O-3-amino-3-deoxyhexopyranosyl-(1→4)-O-[6-amino-6-deoxyhexopyranosyl-(1→6)]-1,3-diamino-1,2,3-trideoxy-; 4,6-Diamino-3-[(6-amino-6-deoxyhexopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxyhexopyranoside. Grade: >95%. CAS No. 1174286-24-8. Molecular formula: C18H36N4O11. Mole weight: 484.51. | |
| Amikacin Sulfate | Amikacin disulfate is an antibiotic that binds to 16S rRNA (bacterial 30S ribosome), causing misreading of mRNA and supressing protein synthesis. Uses: Anti-bacterial agents. Synonyms: BB-K8; BB K8; BBK8; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptamine Sulfate; 1-N-[L-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A Sulfate; Amiglyde V; Amika; Amikacin Disulfate; Amikacin Sulfate; Amikavet; Amikin; Amiklin; Antibiotic BB-K 8 Sulfate; Biklin; Biodacyn; Biodacyna; Fabianol; Grasil; Kaminax; Mikavir; Novamin; Pierami; Selemycin. Grade: 95%. CAS No. 39831-55-5. Molecular formula: C22H47N5O21S2. Mole weight: 781.76. | |
| Amikacin Sulfate Salt | Amikacin Sulfate Salt is an impurity of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Uses: Anti-bacterial agents. Synonyms: (S)-O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine Sulfate (5:9) (Salt); D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, sulfate (5:9) (salt); D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, sulfate (5:9) (salt). Grade: 95%. CAS No. 149022-22-0. Molecular formula: C22H43N5O13.9/5(H2O4S). Mole weight: 762.14. | |
| Amiloride-15N3 Hydrochloride | Labelled Amiloride. Sodium channel blocker. Diuretic. Synonyms: 3,5-Diamino-N-(aminoiminomethyl)-6-chloro-2-pyrazinecarboxamide-15N3 Hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinamide-15N3 Hydrochloride; Amipramidine-15N3; Amipramizide-15N3; Colectril-15N3; Midamor-15N3; Nilurid-15N3. CAS No. 1216796-18-7. Molecular formula: C6H9Cl2N4[15N]3O. Mole weight: 269.07. | |
| Amiloride EP Impurity B | An impurity of Amiloride. Amiloride is a medication typically used with other medications to treat high blood pressure or swelling due to heart failure or cirrhosis of the liver. Synonyms: 3,5-Diamino-6-chloro-pyrazine acid; 3,5-Diamino-6-chloropyrazinecarboxylic acid; 3,5-Diamino-6-chloro-2-pyrazinecarboxylic acid; Amiloride Impurity B; Amiloride Hydrochloride Dihydrate Impurity B; Amiloride Hydrochloride Dihydrate EP Impurity B. Grade: ≥95%. CAS No. 4878-36-8. Molecular formula: C5H5ClN4O2. Mole weight: 188.57. | |
| Amiloride HCl | Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure. Uses: Acid sensing ion channel blockers. Synonyms: Amiloride HCl anhydrous; Amiloride (hydrochloride); Amiloride hydrochloride anhydrous; MK-870 hydrochloride; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride. Grade: ≥ 98%. (HPLC). CAS No. 2016-88-8. Molecular formula: C6H9Cl2N7O. Mole weight: 266.09. | |
| Amiloride Hydrochloride Dihydrate | Amiloride precludes the alkalinization and in parallel inhibit cellular proliferation. Synonyms: Amiloride HCl dihydrate; MK-870 hydrochloride dihydrate; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride dihydrate. Grade: >98%. CAS No. 17440-83-4. Molecular formula: C6H13Cl2N7O3. Mole weight: 302.12. | |
| Amiloride Related Compound A | Amiloride Related Compound. Synonyms: Methyl 3,5-Diamino-6-chloropyrazine-2-carboxylate. Grade: > 95%. CAS No. 1458-01-1. Molecular formula: C6H7ClN4O2. Mole weight: 202.6. | |
| Aminaftone | A Derivative of 4-Aminobenzoic Acid. Uses: Hemostatics. Synonyms: (1,4-dihydroxy-3-methylnaphthalen-2-yl) 4-aminobenzoate. Grade: > 95%. CAS No. 14748-94-8. Molecular formula: C18H15NO4. Mole weight: 309.32. | |
| Aminoacyl tRNA synthetase-IN-1 | Aminoacyl tRNA synthetase-IN-1, is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor. Synonyms: 5'-[[(2S,3S)-2-amino-3-methyl-1-oxopentyl]sulfamate]adenosine. CAS No. 219931-45-0. Molecular formula: C16H25N7O7S. Mole weight: 459.48. | |
| Aminoallyl-CTP | Aminoallyl-CTP is a prominent nucleotide analog harnessed within the field of compound, exhibiting remarkable potential in labeling methodologies encompassing microarray analysand fluorescence in situ hybridization (FISH). Synonyms: 5-Aminoallylcytidine-5'-Triphosphate; 5-AA-CTP; AA-CTP. Grade: ≥90% by AX-HPLC. Molecular formula: C12H21N4O14P3. Mole weight: 538.2. | |
| Aminoallyl-dUTP | Aminoallyl-dUTP is a frequently employed nucleotide analog in the realm of molecular biology exploration, serving as a substrate for DNA polymerases and DNA labeling reactions, specifically the notable fluorescent in situ hybridization (FISH). Upon incorporation into DNA, this peculiar compound expedites the discernment and depiction of distinct DNA sequences within diverse applications, thereby aiding in the visualization and detection processes. Synonyms: Uridine 5'-(tetrahydrogen triphosphate), 5-(3-amino-1-propenyl)-2'-deoxy-; 5-(3-Amino-1-propenyl)-2'-deoxyuridine 5'-(tetrahydrogen triphosphate); 5-(3-Aminoallyl)-2'-deoxyuridine 5'-triphosphate; AA-DUTP; 5-(3-Aminopropyl)-2'-deoxyuridine 5'-(tetrahydrogen triphosphate). Grade: 95%. CAS No. 90015-82-0. Molecular formula: C12H20N3O14P3. Mole weight: 523.22. | |
| Aminoallyl-dUTP - 5/6-TAMRA | Aminoallyl-dUTP - 5/6-TAMRA, a fluorophore-tagged nucleotide, serves as a highly prevalent tool in the fields of biomedical research, specifically in quantitative DNA assays such as microarray analysis and in situ hybridization. Its ubiquity also extends to gene detection probes and DNA labeling for flow cytometry. Intricately designed for detection and quantification, this product is a must-have for scientific endeavors. Synonyms: Tetramethyl-Rhodamine-5-dUTP; 5-(3-Aminoallyl)-2'-deoxyuridine-5'triphosphate, labeled with 5/6-TAMRA, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C37H40N5O18P3 (free acid). Mole weight: 935.66 (free acid). | |
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