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Topopyrone B
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone B selectively inhibits topoisomerase I with the IC50 of 0.15 ng/mL. It also has anti-Gram-positive bacteria activity and it has a strong inhibitory effect on herpes virus, especially varicella zoster virus (VZV). Molecular formula: C18H9ClO7. Mole weight: 372.71.
Topopyrone C
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone C selectively inhibits topoisomerase I with the IC50 of 4.88 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H10O7. Mole weight: 338.27.
Topopyrone D
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 19.63 ng/mL. Molecular formula: C18H10O7. Mole weight: 338.27.
Topostatin
Topostatin is originally isolated from Thermomonos pora alba No. 1520. It has inhibitory effects on human tumor cells, and the IC50 of SNB-75 and SNB-78 were 0.4 μmol/L and 7 μmol/L, respectively. Molecular formula: C36H58N4O11S. Mole weight: 754.93.
Tosufloxacin tosylate
Tosufloxacin is a fluoroquinolone antibiotic with activity against Gram-positive and Gram-negative aerobic bacteria, anaerobic bacteria and Chlamydia trachomatis. It acts as an inhibitor of bacterial DNA gyrase and topoisomerase IV. Synonyms: Tosuxacin; Ozex; 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid tosylate. Grades: ≥95%. CAS No. 115964-29-9. Molecular formula: C26H23F3N4O6S. Mole weight: 576.543.
TPU-0031-A is an antibiotic of the novobiocin group produced by Streptomyces sp. TP-A0556. It shows antibiotic activity against Gram-positive and -negative bacteria. Molecular formula: C30H34N2O11. Mole weight: 598.6.
TPU-0031-B
TPU-0031-B is an antibiotic of the novobiocin group produced by Streptomyces sp. TP-A0556. It shows antibiotic activity against Gram-positive and -negative bacteria. Molecular formula: C30H34N2O11. Mole weight: 598.6.
TPU-0037A
TPU-0037A is a neurogenesis agent isolated from Streptomyces. Synonyms: 30-Demethyllydicamycin. Grades: >95% by HPLC. CAS No. 485815-59-6. Molecular formula: C46H72N4O10. Mole weight: 841.08.
TPU-0037B
TPU-0037B is a lydicamycin congener with anti-MRSA activity isolated from a culture broth of an actinomycete strain. It is closely related to BN 4515N which was isolated from a strain of microtetraspora as a neuritogenic agent. Synonyms: TPU-0037 B. Molecular formula: C47H72N4O9. Mole weight: 837.09.
TPU-0037C
A close structural analogue of lydicamycin produced by the marine actinomycete Streptomyces platensis. It has antibacterial activity against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). It is closely related to BU-4514N which is isolated from a strain of microtetraspora as a neuritogenic agent. Synonyms: Antibiotic TPU-0037C; 8-Dehydroxy-30-demethyllydicamycin; (+)?-2-[21-[1-[(2,?5-Dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)?carbonyl]?-1,?2,?4a,?5,?6,?7,?8,?8a-octahydro-5-hydroxy-1,?3-dimethyl-2-naphthalenyl]?-2,?6,?10,?14,?18-pentahydroxy-11,?17,?19-trimethyl-4,?8,?12,?16-heneicosatetraen-1-yl]?-1-pyrrolidinecarboximi?damide. Grades: >95% by HPLC. CAS No. 485815-61-0. Molecular formula: C46H72N4O9. Mole weight: 825.09.
TPU-0037D
TPU-0037D is a lydicamycin congener with anti-MRSA activity isolated from a culture broth of an actinomycete strain. It is closely related to BN 4515N which was isolated from a strain of microtetraspora as a neuritogenic agent. Synonyms: TPU-0037 D. Molecular formula: C47H74N4O9. Mole weight: 839.11.
Trametol is produced from the culture medium of Bjerkandera sp. BOS55. Synonyms: 1,2-Propanediol, 1-(3-chloro-4-methoxyphenyl)-, (1R,2S)-. Grades: ≥98%. CAS No. 169217-47-4. Molecular formula: C10H13ClO3. Mole weight: 216.66.
Transplatin
The less-active isomer of the DNA damanging, platinum antitumor drug cisplatin. Transplatin is used in the treatment of a variety of solid tumors. Transplatin's anti-tumor activity can be activated by light. Synonyms: Trans-Dichlorodiamineplatinum(II); Azane; Cisplatin. CAS No. 14913-33-8. Molecular formula: Cl2H6N2Pt. Mole weight: 300.05.
TRAP-6 (2-6)
PAR peptides (TRAP peptides and thrombin receptor-like peptides) activate the proteinase-activated receptors PAR-1 to PAR-4. Synonyms: THROMBIN RECEPTOR AGONIST; THROMBIN RECEPTOR (43-47), HUMAN; PHE-LEU-LEU-ARG-ASN; TR (43-47), HUMAN; H-PHE-LEU-LEU-ARG-ASN-OH; FLLRN; phenylalanyl-leucyl-leucyl-arginyl-asparagine; TRAP-6 (2-6). CAS No. 141136-84-7. Molecular formula: C31H51 N9 O7. Mole weight: 661.79.
TRAP-6 amide
TRAP-6 amide is a peptide agonist of the PAR-1 thrombin receptor. Synonyms: SFLLRN-NH2; TRAP6; Ser-Phe-Leu-Leu-Arg-Asn-NH2. CAS No. 141923-40-2. Molecular formula: C34H57N11O8. Mole weight: 747.89.
Trehalosamine
Trehalosamine is a carbohydrate antibiotic originally isolated from Str. sp. It has anti-gram-positive bacteria and Pseudomonas aeruginosa and mycobacterium action. Synonyms: 2-Trehalosamine; 2-amino-2-deoxy-alpha-D-glucopyranosyl alpha-D-glucopyranoside; alpha-D-Glucopyranosyl 2-amino-2-deoxy-alpha-D-glucopyranoside. CAS No. 27208-79-3. Molecular formula: C12H23NO10. Mole weight: 341.31.
Trestatin A
It is produced by the strain of Str. dimorphogenes NR-320-OM7HB. Trestatin A has a strong inhibitory effect on pancreatic α-amylase, and also inhibits the α-amylase of Bacillus subtilis and Aspergillus oryzae. Synonyms: Ro 09-0183. CAS No. 71884-70-3. Molecular formula: C56H94N2O40. Mole weight: 1435.33.
Trestatin B
It is produced by the strain of Str. dimorphogenes NR-320-OM7HB. Trestatin B has a strong inhibitory effect on pancreatic α-amylase, and also inhibits the α-amylase of Bacillus subtilis and Aspergillus oryzae. Synonyms: Ro 09-0184; alpha-D-Glucopyranoside, alpha-D-glucopyranosyl O-4,6-dideoxy-4-((4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl)amino)-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-, (1S-(1-alpha,4-alpha,5-beta,6-alpha))-. CAS No. 71869-92-6. Molecular formula: C37H63NO28. Mole weight: 969.88.
Trestatin C
It is produced by the strain of Str. dimorphogenes NR-320-OM7HB. Trestatin C has a strong inhibitory effect on pancreatic α-amylase, and also inhibits the α-amylase of Bacillus subtilis and Aspergillus oryzae. Synonyms: Ro 09-0185. CAS No. 71892-68-7. Molecular formula: C75H125N3O52. Mole weight: 1900.78.
Triacetylphloroglucinol
It is the most hydrophobic of a small molecular weight phenolic metabolite belonging to the phloroglucinol (1,3,5 trihydroxybenzene) family. It is produced by pseudomonas fluoresces and exhibits a broad range of biological activities. It is important for dereplication to eliminate leads due to high amounts of weakly potent actives. Synonyms: Phloroglucinol 2,4,6-Triacetate; 2,4,6-Triacetyl-1,3,5-trihydroxybenzene; 2,4,6-Triacetylphloroglucinol; 1,1',1''-(2,4,6-Trihydroxybenzene-1,3,5-triyl)triethanone. Grades: >98% by HPLC. CAS No. 2161-87-7. Molecular formula: C12H12O6. Mole weight: 252.22.
Triacsin C
Triacsin C, originally isolated from Streptomyces sp., is a polyunsaturated fatty acid derivative. It has been found to be an acyl-CoA synthetase inhibitor as well as an effective vasodilator. It selectively inhibits arachidonoyl-CoA synthetase in intact cells and the nonspecific acyl-CoA synthetase in cell sonicates, as well as inhibits neutrophil functions. Synonyms: 2E,4E,7E-Undecatriene-1-triazene; WS 1228A; 1-Hydroxy-3-(2',4',7'-undecatrienylidine)triazene. Grades: ≥95%. CAS No. 76896-80-5. Molecular formula: C11H17N3O. Mole weight: 207.30.
Trichodion
Trichodion is originally isolated from Trichosporiella sp. It inhibits the expression of secretion alkaline phosphatase (SEAP) Reporter gene mediated by IFN-V with IC50 of 5-10 μg/mL, and it also inhibits the expression of human IFN-α promoter-driven Luciferase Reporter gene with IC50 of 2.5-5μg/mL. Molecular formula: C12H14O5. Mole weight: 238.24.
Trichostatin C
Trichostatin C can protect the more unstable N-OH group of trichostatin A. It has anti-fungal, protozoan and anti-tumor activity. Synonyms: 145-A. Grades: >95% by HPLC. CAS No. 68676-88-0. Molecular formula: C23H32N2O8. Mole weight: 464.51.
Trichostatin RK
Trichostatin RK is a trigustatine derivative produced by the strain of Streptomyces sp. RK98-A74. It can induce luciferase, but its activity is lower than that of trigustatin. Molecular formula: C18H24N2O2. Mole weight: 300.39.
Trichothecin
Trichothecin has anti-fungal and protozoal effects and it's produced by the strain of Trichothecium roseum. Synonyms: NSC 92492; 12,13-Epoxy-4-hydroxytrichothec-9-en-8-one crotonate. CAS No. 6379-69-7. Molecular formula: C19H24O5. Mole weight: 332.39.
Tridecaptin A
It is an antibiotic with antimicrobial properties produced by the strain of Bacillus polymyxa AR-110. Synonyms: D-2,4-diaminobutanoylglycyl-Dseryl-D-tryptophyl-L-seryl-L-2,4-diaminobutanoyl-D-2,4-diaminobutanoyl-L-phenylalanyl-L-r-glutamyl-L-valyl-Dalloisoleucyl. CAS No. 67922-28-5. Molecular formula: C73H115N17O20. Mole weight: 1550.79.
Tridecaptin C
It is an antibiotic with antimicrobial properties produced by the strain of Bacillus polymyxa B-2. CAS No. 67922-31-0. Molecular formula: C74H117N17O21. Mole weight: 1580.82.
Trifluoromethane sulfonic acid
Strong acid catalyst for the industry; Intermediate for liquid crystals; used to prepare trifluoromesulfonic anhydride and various derivatives of trifluoromesulfonic acid. Grades: ≥ 99% (Titration). CAS No. 1493-13-6. Molecular formula: CF3SO3H. Mole weight: 150.07.
Triiodobenzoic Acid
Used as a plant growth regulator and controller. It suppresses somatic embryo formation and postembryonic shoot/root development in eleutherococcus senticosus. Synonyms: 2,3,5-TIBA; A 20812; Floraltone; Johnkolor; NSC 2582; TIB; TIBA. Grades: ≥ 98 %. CAS No. 88-82-4. Molecular formula: C7H3I3O2. Mole weight: 499.81.
Triisopropylsilane
Protective agent of peptide synthesis. Synonyms: TIPS. Grades: ≥ 99% (GC). CAS No. 6485-79-6. Molecular formula: C9H22Si. Mole weight: 158.36.
Trimethoprim
Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections. It caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. It binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). Uses: Anti-infective agents, urinary; antimalarials; antimetabolites; folic acid antagonists. Synonyms: Trimpex; Proloprim. Grades: >98%. CAS No. 738-70-5. Molecular formula: C14H18N4O3. Mole weight: 290.32.
Trimethoprim lactate
Trimethoprim lactate salt is used as an antibacterial agent, primarily active against most gram-negative and gram-positive aerobic bacteria. It inhibits dihydrofolate reductase. Synonyms: Trimethoprim lactic Acid. Grades: ≥98%. CAS No. 23256-42-0. Molecular formula: C17H24N4O6. Mole weight: 380.39.
Trinactin
Trinactin is a tetracyclic lactone compound produced by Streptomyces. It is a monovalent cation ionophore with high selectivity to ammonium and potassium. It can inhibit the proliferation of T cells induced by IL-2, and inhibit the production of cytokines at nanomolar levels of IL-2, IL-4, IL-5 and interferon-&gamma. Synonyms: AKD-1D; S 3466B. Grades: >95% by HPLC. CAS No. 7561-71-9. Molecular formula: C43H70O12. Mole weight: 779.0.
Triostin A
The compound of triosteomycin exhibited anti-gram-positive bacteria and mycobacteria, and had a strong inhibitory effect on Miyono adenocarcinoma, Ridgway osteosarcoma, Mecca lymphoid sarcoma and leukemia. Synonyms: N,N'-[(1R,4S,7R,11S,14R,17S,20R,24S)-11,24-Diisopropyl-2,4,12,15,17,25-hexamethyl-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28,29-dithia-2,5,12,15,18,25-hexaazabicyclo[12.12.4]triacontan-7,20-diyl]di(2-chinoxalincarboxamid). Grades: 99%. CAS No. 13758-27-5. Molecular formula: C50H62N12O12S2. Mole weight: 1087.23.
Triostin C
Triostin C is produced by the strain of Str. triostinicus S-2-210. Triostin C exhibited anti-gram-positive bacteria and mycobacteria activity, and had a strong inhibitory effect on Miyono adenocarcinoma, Ridgway osteosarcoma, Mecca lymphoid sarcoma and leukemia. Synonyms: BRN 1071175; N-[2,4,12,15,17,25-hexamethyl-11,24-bis(3-methylbutan-2-yl)-3,6,10,13,16,19,23,26-octakis(oxidanylidene)-20-(quinoxalin-2-ylcarbonylamino)-9,22-dioxa-28,29-dithia-2,5,12,15,18,25-hexazabicyclo[12.12.4]triacontan-7-yl]quinoxaline-2-carboxamide. CAS No. 10382-35-1. Molecular formula: C54H70N12O12S2. Mole weight: 1143.33.
Triphenylmethylamine
Triphenylmethylamine is structurally related to Clotrimazole, which is an antifungal medication commonly used in the treatment of fungal infections. Synonyms: α,α-Diphenylbenzenemethanamine; Tritylamine; Aminotriphenylmethane; NSC 1154; Triphenylmethanamine. Grades: ≥95%. CAS No. 5824-40-8. Molecular formula: C19H17N. Mole weight: 259.34.
Tripropeptin A
Tripropeptin A is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL. Molecular formula: C49H79N11O19. Mole weight: 1126.21.
Tripropeptin B
Tripropeptin B is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL. Molecular formula: C50H81N11O19. Mole weight: 1140.24.
Tripropeptin C
Tripropeptin C is a cyclic peptide antibiotic originally isolated from Lysobacter sp. BMK333-48F3. It has anti-Gram-positive bacteria activity against Staphylococcus (including MRSA), Streptococcus and Enterococcus, with MIC of 0.78-12.5μg/mL. Molecular formula: C51H83N11O19. Mole weight: 1154.26.
Triptorelin
An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist anal ogue of gonadotropin-releasing hormone. Uses: Antineoplastic agents, hormonal. Synonyms: Triptoreline; Decapeptyl; Arvekap; (D-Trp6)-GnRH; Triptorelina; Triptorelinum; Trelstar; (6-D-Tryptophan)luteinizing hormone-releasing hormone; CL 118532; CL-118532; pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. Grades: >98%. CAS No. 57773-63-4. Molecular formula: C64H82N18O13. Mole weight: 1311.47.
It is an antibiotic with anti-tumor effects originally isolated from Aclacinomycin KE303. Synonyms: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-8-(1-hydroxyethyl)-10-((2,3,6-trideoxy-4-O-(2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl)-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-. CAS No. 80470-08-2. Molecular formula: C40H51NO15. Mole weight: 785.83.
Tritrpticin
Tritrpticin is an antimicrobial peptide isolated from Sus scrofa. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: H-Val-Arg-Arg-Phe-Pro-Trp-Trp-Trp-Pro-Phe-Leu-Arg-Arg-OH. Grades: >95%. CAS No. 179264-81-4. Molecular formula: C96H132N28O14. Mole weight: 1902.3.
Starting material for the alkylation of threonine. Grades: ≥ 98% (HPLC). CAS No. 80514-76-7. Molecular formula: C23H23NO3·C6H15N. Mole weight: 462.60.
Tropodithietic acid
Tropodithietic acid (TDA) is a broad-spectrum antibiotic produced by the marine bacterium Roseobacter gallaeciensis. It is effective against a variety of Gram-negative α-proteobacteria, γ-proteobacteria, and flavobacteria as well as Gram-positive actinobacteria strains in a disc assay. Synonyms: TDA. Grades: ≥98%. CAS No. 750590-18-2. Molecular formula: C8H4O3S2. Mole weight: 212.25.
Tropolone
A bactericidal antibiotic composed of a seven membered aromatic ring. Synonyms: Purpurocatechol. Grades: ≥ 99 %. CAS No. 533-75-5. Molecular formula: C7H6O2. Mole weight: 122.12.
It is produced by the strain of Aspergillus fumigatus. Trypacidin has anti-protozoal and spirochete effects, but the effect on the latter is weak. Synonyms: BRN 1299866; Methyl 4,6'-dimethoxy-6-methyl-3,4'-dioxo-3H-spiro[1-benzofuran-2,1'-cyclohexa[2,5]diene]-2'-carboxylate. Grades: ≥98% by HPLC. CAS No. 1900-29-4. Molecular formula: C18H16O7. Mole weight: 344.31.
Tryprostatin B
Tryprostatin B is a natural compound isolated from Aspergillus fumigatus and arrests cell cycle progression at the G2/M phase. Synonyms: triprostatin B; (-)-Tryprostatin B; (3S,8aS)-3-{[2-(3-methylbut-2-en-1-yl)-1H-indol-3-yl]methyl}hexahydropyrrolo[1,2-a]pyrazine-1,4-dione. CAS No. 179936-52-8. Molecular formula: C21H25N3O2. Mole weight: 351.44.
TS 155-2
A macrocyclic lactone related to hygrolidin but produced by a different streptomyces species. TS155-2 is an inhibitor of calcium entry into the cell induced by thrombin stimulation. It has antihypertensive, antiplatelet, antiischemia and anti-inflammatory activities. Synonyms: Antibiotic TS 155-2; 2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H-pyran-4-yl] ester; JBIR 100. Grades: >95% by HPLC. CAS No. 303009-07-6. Molecular formula: C39H60O11. Mole weight: 704.89.
Tuberactinomycin A
Tuberactinomycin A is produced by the strain of Streptoverticillium griseoverticillatus var. tuberacticus B-386. It is effective against mycobacteria, but less effective against gram-positive and gram-negative bacteria. CAS No. 33103-21-8. Molecular formula: C25H43N13O11. Mole weight: 701.69.
Tuberin
Tuberin is produced by the strain of Str.amakusaensis 10-101 and it is resistant to mycobacteria. Synonyms: N-Formyl-T-P-methoxystyrilamine; NSC 7382; N-trans-(p-Methoxystyryl)formamide. CAS No. 53643-53-1. Molecular formula: C10H11NO2. Mole weight: 177.20.
Tubulysin B
Tubulysin B is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates. It also has anti-fungal properties. Synonyms: (2S,4R)-2-Methyl-4-[2-[(1R,3R)-1-acetoxy-3-[[N-[[(2R)-1-methyl-2beta-piperidinyl]carbonyl]-L-isoleucyl](butanoyloxymethyl)amino]-4-methylpentyl]thiazole-4-ylcarbonylamino]-5-(4-hydroxyphenyl)pentanoic acid. Grades: ≥95%. CAS No. 205304-87-6. Molecular formula: C42H63N5O10S. Mole weight: 830.04.
Tubulysin C
Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis. Synonyms: Tubulysin C; 205304-88-7; 072P54KU0L; UNII-072P54KU0L; (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-(propanoyloxymethyl)amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid; Benzenepentanoic acid, gamma-(((2-((1R,3R)-1-(acetyloxy)-4-methyl-3-(((2S,3S)-3-methyl-2-((((2R)-1-methyl-2-piperidinyl)carbonyl)amino)-1-oxopentyl)((1-oxopropoxy)methyl)amino)pentyl)-4-thiazolyl)carbonyl)amino)-4-hydroxy-alpha-methyl-, (alphaS. ga; SCHEMBL24218753; EX-A5466C; HY-N2347; AKOS040740942; CS-0021784; BENZENEPENTANOIC ACID. GAMMA.-(((2-((1R,3R)-1-(ACETYLOXY)-4-METHYL-3-(((2S,3S)-3-METHYL-2-((((2R)-1-METHYL-2-PIPERIDINYL)CARBONYL)AMINO)-1-OXOPENTYL)((1-OXOPROPOXY)METHYL)AMINO)PENTYL)-4-THIAZOLYL)CARBONYL)AMINO)-4-HYDROXY-.ALPHA.-METHYL-, (.ALPHA.S. GAMMA.R)-. Grades: 98%. CAS No. 205304-88-7. Molecular formula: C41H61N5O10S. Mole weight: 816.02.
Tubulysin D
Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. It displays potent antitumor activity and leads to cell cycle arrest and apoptosis by inhibiting tubulin polymerization with an IC50 of 1.7 μM. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range. Synonyms: (+)-Tubulysin D. Grades: ≥98%. CAS No. 309935-57-7. Molecular formula: C43H65N5O9S. Mole weight: 828.07.