BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AGN 196996 | AGN 196996 is a potent and selective antagonist of RARα. It has been reported to selectively bind to RARs (retinoic acid receptors) for RARα, RARβ and RARγ. It can inhibit the gene transcription activity which induced by ATRA and other RAR agonists. It shows no activity in transactivation assays, but instead block the gene transcriptional activity induced by ATRA and other RAR agonists. Grade: >98%. CAS No. 958295-17-5. Molecular formula: C24H20BrNO5. Mole weight: 482.32. |  |
| AGN 203818 | AGN 203818 is an α2-adrenergic receptor antagonist that can be used to treat fibromyalgia-associated pain. Synonyms: 2H-Imidazole-2-thione, 4-[1-(2,3-dimethylphenyl)ethyl]-1,3-dihydro-, hydrochloride (1:1); 4-[1-(2,3-Dimethylphenyl)ethyl]-1,3-dihydro-2H-imidazole-2-thione hydrochloride (1:1); AGN203818; AGN-203818; AGN 203818 hydrochloride. Grade: ≥95%. CAS No. 1021954-16-4. Molecular formula: C13H16N2S.HCl. Mole weight: 268.81. | |
| AGN 205327 | AGN 205327 is a potent synthetic RARs agonist with EC50 of 3766, 734, 32 nM for RARα, β, γ respectively. Synonyms: AGN205327; AGN-205327. Molecular formula: C24H26N2O3. Mole weight: 390.47. | |
| AGN 205728 | AGN 205728 is a potent and selective RARγ antagonist and has no inhibiton on RARα and RARβ. Synonyms: AGN 205728; AGN205728; AGN-205728. Grade: >98%. CAS No. 859498-05-8. Molecular formula: C29H27NO3. Mole weight: 437.53. | |
| AGN 210676 | AGN 210676 is a small molecule prostaglandin E2 receptor agonist under development for the treatment of glaucoma and ocular hypertension. Synonyms: Simenepag; AGN-210676; AGN210676; 5-((((r)-1-(4-((s)-1-hydroxyhexyl)phenyl)-5-oxopyrrolidin-2-yl)methoxy)methyl)thiophene-2-carboxylic acid. Grade: 95%. CAS No. 910562-15-1. Molecular formula: C23H29NO5S. Mole weight: 431.55. | |
| Agomelatine Impurity 2 | An analogue of Agomelatine. Synonyms: (E)-1-[2-(acetylamino)ethylidene]; (E)-N-(2-(7-methoxy-3,4-dihydronaphthalen-1(2H)-ylidene. Grade: > 95%. CAS No. 178677-39-9. Molecular formula: C15H19NO2. Mole weight: 245.32. | |
| Agomelatine Impurity A | Agomelatine Impurity A is an impurity originating from the renowned Agomelatine, a notable depression-alleviating medication. CAS No. 32820-10-3. Molecular formula: C11H14O2. | |
| Agomelatine Impurity B | An analogue of Agomelatine. Synonyms: 2-(7-Methoxynaphthalen-1-yl)acetamide. Grade: > 95%. CAS No. 138113-07-2. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
| Agomelatine Impurity D | An analogue of Agomelatine. Synonyms: N-Acetyl-N-[2-(7-methoxy-1-naphthalenyl)ethyl]acetamide. Grade: > 95%. CAS No. 1379005-34-1. Molecular formula: C17H19NO3. Mole weight: 285.35. | |
| Agomelatine Impurity II | An analogue of Agomelatine. Synonyms: Agomelatine Dimer Urea. Grade: > 95%. CAS No. 185421-27-6. Molecular formula: C27H28N2O3. Mole weight: 428.54. | |
| Agonodepside B | Agonodepside B is a fungal metabolite produced by the strain of the endophytic fungus F7524. Synonyms: benzoic acid, 4-[[2,4-dihydroxy-3-methyl-6-[(1E)-1-methyl-1-propenyl]benzoyl]oxy]-2-hydroxy-3-methyl-6-[(1E)-1-methyl-1-propenyl]-. Grade: >95%. CAS No. 445298-41-9. Molecular formula: C24H26O7. Mole weight: 426.46. | |
| AH 001 | AH 001 is a potent melatonin agonist. Synonyms: AH 001; AH001; AH-001; 8-Methoxy-2-acetamidotetralin; N-(8-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide. Grade: 98%. CAS No. 80270-68-4. Molecular formula: C13H17NO2. Mole weight: 219.28. | |
| AH 11110 hydrochloride | The hydrochloride salt form of AH 11110, which is an α1B-adrenoceptor ligand and has been found to exhibit interaction with α1-adrenoceptors as well as α2-adrenoceptors. Synonyms: AH 11110 hydrochloride; AH11110 hydrochloride; AH-11110 hydrochloride; 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride. Grade: ≥98% by HPLC. CAS No. 179388-65-9. Molecular formula: C21H26N2O2.HCl. Mole weight: 374.91. | |
| AH 23848 calcium salt | AH-23848 is a dual antagonist of TP1 and EP4 receptors. Uses: Anti-arrhythmia agents. Synonyms: AH23848; (Z)-7-[(1R,2R,5S)-2-morpholin-4-yl-3-oxo-5-[(4-phenylphenyl)methoxy]cyclopentyl]hept-4-enoic acid; 81496-19-7; AH 23848; AH-23848; AH-23848B; (-)AH23848; (-)-AH23848; GTPL1949; SCHEMBL3488581; CHEBI:90389; 81443-73-4; (1R,2R,5S)-AH23848; (-)-AH 23848; Q27074357; (4Z)-7-[(1R,2R,5S)-5-[([1,1'-biphenyl]-4-yl)methoxy]-2-(morpholin-4-yl)-3-oxocyclopentyl]hept-4-enoic acid; Rel-(Z)-7-((1R,2R,5S)-5-([1,1'-biphenyl]-4-ylmethoxy)-2-morpholino-3-oxocyclopentyl)hept-4-enoic acid. Grade: ≥90%. CAS No. 81496-19-7. Molecular formula: C29H34NO5·1/2Ca. Mole weight: 993.2. | |
| AH3960 | AH3960 is an agonist of parathyroid hormone receptor-1 (PTHR1). Synonyms: Trione; AH 3960; AH-3960; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-5-(diaminomethylene)-; 1,3-Dibutyl-5-(diaminomethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione; 1,3-dibutyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide. Grade: >98%. CAS No. 862907-48-0. Molecular formula: C13H22N4O3. Mole weight: 282.34. | |
| AH 6809 | AH 6809 is an EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptor antagonist. Uses: An ep and dp receptor antagonist with nearly equal affinity for the cloned human ep1, ep2, ep3-iii, and dp1 receptors. Synonyms: AH 6809; AH6809; AH-6809; 6-isopropoxy-9-oxoxanthene-2-carboxylic acid. Grade: ≥95.0%. CAS No. 33458-93-4. Molecular formula: C17H14O5. Mole weight: 298.29. | |
| AH 7614 | AH 7614 is a FFA4/GPR120 antagonist and has been found to exhibit effects in restraining intracellular calcium accumulation induced by either linoleic acid or a FFAR4 agonist. Synonyms: AH 7614; AH7614; AH-7614; 4-Methyl-N-9H-xanthen-9-yl-benzenesulfonamide. Grade: ≥98% by HPLC. CAS No. 6326-6-3. Molecular formula: C20H17NO3S. Mole weight: 351.42. | |
| a-Homonojirimycin | a-Homonojirimycin is a inhibitor of the enzymatic compound called glucosidase used for studying lysosomal storage diseases like Gaucher disease and Pompe disease. Synonyms: α-HNJ; (2R,3R,4R,5S,6R)-2,6-β(dihydroxymethyl)piperidine-3,4,5-triol; α-Homonojirimycin; 3,4,5-Piperidinetriol, 2,6-bis(hydroxymethyl)-, [2R-(2α,3α,4β,5α,6β)]-; (2R,3R,4R,5S,6R)-2,6-Bis(hydroxymethyl)-3,4,5-piperidinetriol; 2,6-Dideoxy-2,6-imino-D-glycero-L-gulo-heptitol; Homonojirimycin; 3,4,5-Piperidinetriol, 2,6-bis(hydroxymethyl)-, (2α,3α,4β,5α,6β)-. Grade: ≥98%. CAS No. 119557-99-2. Molecular formula: C7H15NO5. Mole weight: 193.20. | |
| AHR antagonist 2 | AHR antagonist 2 is a potent aryl hydrocarbon receptor (AHR) antagonist, extracted from patent WO2019101641A1, compound example 1. Synonyms: AHR antagonist 2; 2338747-54-7; SCHEMBL21001701; CSSGBPKFVJOAIZ-LBPRGKRZSA-N; AKOS040732400; MS-27306; HY-135831; CS-0114332; N-[(2S)-1-hydroxypropan-2-yl]-2-pyridin-3-yl-6-[4-(trifluoromethoxy)phenyl]pyrimidine-4-carboxamide. Grade: 99%. CAS No. 2338747-54-7. Molecular formula: C20H17F3N4O3. Mole weight: 418.37. | |
| AHR antagonist 4 | AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 293; IC50 = 82.2 nM). It has anti-cancer effects. CAS No. 2242465-58-1. Molecular formula: C20H14F6N4O4. Mole weight: 488.34. | |
| AHR Antagonist 5 | AHR Antagonist 5, an effective and orally active aromatic hydrocarbon receptor (AHR) antagonist with IC50 of less than 0.5 μM. It can significantly inhibit tumor growth in combination with the checkpoint inhibitor anti-PD-1. Synonyms: BCP33104; HY-136220; CS-0120848; (R)-N-(2-(5-Fluoropyridin-3-Yl)-8-Isopropylpyrazolo[1,5-A][1,3,5]Triazin-4-Yl)-2,3,4,9-Tetrahydro-1H-Carbazol-3-Amine Trihydrochloride. Grade: ≥98% by HPLC. CAS No. 2247953-39-3. Molecular formula: C25H27Cl3FN7. Mole weight: 550.9. | |
| AHR antagonist 5 free base | AHR antagonist 5 free base, a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor, effectively blocks AHR from translocating from the cytoplasm to the nucleus. AHR antagonist 5 free base is highly selective for AHR over other receptors, transporters, and kinases. CAS No. 2247950-42-9. Molecular formula: C25H24FN7. Mole weight: 441.50. | |
| AHR antagonist 5 hemimaleate | AHR antagonist 5 hemimaleate is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist with an IC50 of < 0.5 μΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. Molecular formula: C29H28FN7O4. Mole weight: 499.55. | |
| AhR modulator-1 | AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator with anti-estrogenic properties in rat uterus. It inhibits metastasis in part by inhibiting prostatic VEGF production prior to tumor formation. Synonyms: 6-Methyl-1,3,8-trichlorodibenzofuran; MCDF; 6-MCDF; Dibenzofuran, 6-methyl-1,3,8-trichloro-; 1,3,8-Trichloro-6-methyldibenzo[b,d]furan. Grade: ≥90%. CAS No. 118174-38-2. Molecular formula: C13H7Cl3O. Mole weight: 285.55. | |
| AHU-377 hemicalcium salt | LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms. Synonyms: calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; AHU337; AHU-337; AHU 337; LCZ696; LCZ 696; LCZ696; Sacubitril. Grade: >98%. CAS No. 1369773-39-6. Molecular formula: C24H28NO5-. Mole weight: 410.48. | |
| AI-10-49 | AI-10-49 is a protein-protein interaction inhibitor that selectively binds to CBFβ-SMMHC and disrupts its binding to RUNX1 with a FRET IC50 of 0.26 uM. Synonyms: AI-10-49; AI 10-49; AI10-49; AI-1049; AI 1049; AI1049. Grade: >98%. CAS No. 1256094-72-0. Molecular formula: C30H22F6N6O5. Mole weight: 660.52. | |
| AI-3 | AI-3 is an antioxidant response element activator and could probably be useful in studies of oxidative stress related diseases. Synonyms: AI-3; AI 3; AI3; 1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one. Grade: ≥98% by HPLC. CAS No. 882288-28-0. Molecular formula: C11H13ClO3S2. Mole weight: 292.80. | |
| AICAR 3',5'-Cyclic Phosphate | A cyclic nucleotide with protein kinase and phosphodiesterase activity. Synonyms: 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 3':5'-cyclic-monophosphate; 5-Amino-1-(3,5-O-phosphinico-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; NSC 371796. Grade: 94%. CAS No. 35908-14-6. Molecular formula: C9H13N4O7P. Mole weight: 320.2. | |
| AICAR-5'-MP / ZMP | AICAR-5'-MP is an analogue of AICA-riboside, an alternative of 5'-AMP. AICAR-5'-MP is a purine precursor with antineoplastic activity and can be used in the study of type 2 diabetes. It can activate AMP-activated protein kinase. Synonyms: 1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-β-D-ribofuranosyl)-; 5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5'-(dihydrogen phosphate); Imidazole-4-carboxamide, 5-amino-1-β-D-ribofuranosyl-, 5'-phosphate; 5-Amino-1-(5'-phosphofuranoribosyl)-4-imidazolecarboxamide; 5-Amino-1β-D-ribofuranosylimidazole-4-carboxamide 5'-phosphate; 5-Amino-4-imidazolecarboxamide ribonucleoside 5'-monophosphate; 5-Amino-4-imidazolecarboxamide ribonucleotide; 5-Amino-4-imidazolecarboxamide riboside 5'-monophosphate; 5-Amino-4-imidazolecarboxamide ribotide; 5-Aminoimidazole-4-carboxamide ribonucleotide; 5'-Phospho-β-D-ribosyl-5-amino-4-imidazolecarboxamide; 5'-Phosphoribosyl-5-amino-4-imidazolecarboxamide; Acadesine 5'-monophosphate; AICA Ribotide; AICA-Ribonucleotide; AICAR; AICAR monophosphate; AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5'-monophosphate); Aminoimidazolecarboxamide ribonucleotide; NSC 283955; NSC 292227; ZMP; ZMP (alarmone). Grade: ≥95%. CAS No. 3031-94-5. Molecular formula: C9H15N4O8P. Mole weight: 338.21. | |
| AICAR phosphate | AICAR phosphate, is an AMP-activated protein kinase activator, which is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. It stimulates glucose uptake and increases the activity of p38 mitogen-activated protein kinases α and β in skeletal muscle tissue, as well as suppressing apoptosis by reducing production of reactive oxygen compounds inside the cell. Synonyms: Acadesine phosphate; AICA Riboside phosphate. Grade: >98%. CAS No. 681006-28-0. Molecular formula: C9H17N4O9P. Mole weight: 356.23. | |
| AIDA | AIDA is a selective group I mGluR agonist and could show centrally active following systemic administration in vivo. Uses: Excitatory amino acid antagonists. Synonyms: (RS)-1-Aminoindan-1,5-dicarboxylic acid. Grade: ≥98% by HPLC. CAS No. 168560-79-0. Molecular formula: C11H11NO4. Mole weight: 221.21. | |
| AIM-100 | AIM-100 is a small molecule inhibitor of Ack1. It not only inhibited Ack1 activation but also suppressed AKT tyrosine phosphorylation, leading to cell cycle arrest in the G1 phase. It could suppress AR Tyr(267) phosphorylation and its recruitment to the ATM enhancer and suppress pTyr267-AR phosphorylation, binding of AR to PSA, NKX3.1, and TMPRSS2 promoters, and inhibit AR transcription activity. Synonyms: AIM-100; AIM 100; AIM100. Grade: >98%. CAS No. 873305-35-2. Molecular formula: C23H21N3O2. Mole weight: 371.43. | |
| Ajoene | Ajoene is a disulfide that has been found in A. sativum and has antitumor and antiplatelet activities. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Uses: Antiviral agents. Synonyms: (E)-Ajoene; 2-Propenyl-3-(2-propenylsulfinyl)-1-propenyl disulfide. CAS No. 92285-01-3. Molecular formula: C9H14OS3. Mole weight: 234.4. | |
| AK-1 | AK-1 is a potent, specific and cell-permeable SIRT2 inhibitor (IC50 = 12.5 μM) with excellent selectivity against SIRT1 and SIRT3 (IC50 >50 μM, and >50 μM for SIRT1 and SIRT3 respectively). Synonyms: AK-1; AK 1; AK1; DA-42784; KB-120200; Y1899; J-018989; DA42784; KB120200; J018989; DA 42784; KB 120200; J 018989; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide; SIRT2 Inhibitor II, AK-1; SIRT2 Inhibitor II; CHEMBL1797749; 3-(azepan-1-ylsulfonyl)-N-(3-nitrophenyl)benzamide. CAS No. 330461-64-8. Molecular formula: C19H21N3O5S. Mole weight: 403.45. | |
| AK-7 | AK-7 is a selective and brain-permeable SIRT2 inhibitor, which displays no effect on SIRT1 or SIRT3. It could decrease neuronal cholesterol levels and improve motor function and ameliorates brain atrophy in a mouse model of Huntington's disease. Synonyms: AK-7; CS-3223; GL-8955; AK7; CS3223; GL8955; AK 7; CS 3223; GL 8955. Grade: >98%. CAS No. 420831-40-9. Molecular formula: C19H21BrN2O3S. Mole weight: 437.35. | |
| AKI-001 | AKI-001 is a potent Aurora kinase inhibitor, which exhibits low nanomolar potency against both Aurora A and Aurora B enzymes, excellent cellular potency (IC50 < 100 nM), and good oral bioavailability. Synonyms: AKI-001; AKI 001; AKI001. Grade:>98%. CAS No. 925218-37-7. Molecular formula: C21H24N4O. Mole weight: 348.45. | |
| AKI603 | AKI603 is an inhibitor of Aurora kinase A (AurA) with IC50 of 12.3 nM. It can induce senescence in chronic myeloid leukemia cells carrying the T315I mutation. AKI603 shows strong anti-proliferative activity in leukemia cells. Synonyms: AKI-603. Grade: 98%. CAS No. 1432515-73-5. Molecular formula: C19H23N9O2. Mole weight: 409.4. | |
| Aklomide | Aklomide is antiprotozoal agent against coccidiosis. Synonyms: 2-chloro-4-nitrobenzamide 2-Chloro-4-nitrobenzamide aklomide 3011-89-0 Aklomix Clomide Alkomide Benzamide, 2-chloro-4-nitro- component of Aklomix component of Novastat-W. CAS No. 3011-89-0. Molecular formula: C7H5ClN2O3. Mole weight: 200.58. | |
| AKN-028 | AKN-028, the FLT3/KIT kinase inhibitor, is an orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases. Synonyms: AKN 028; AKN028; N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine; 2,3-Pyrazinediamine, N3-1H-indol-5-yl-5-(4-pyridinyl)-; N3-(1H-Indol-5-yl)-5-(4-pyridinyl)-2,3-pyrazinediamine. Grade: ≥95%. CAS No. 1175017-90-9. Molecular formula: C17H14N6. Mole weight: 302.33. | |
| AKOS B018304 | AKOS B018304 is a potent inhibitor of chikungunya virus with low micromolar activity. Synonyms: (E)-2-Mercapto-5-(2-Nitrobenzylidene)Thiazol-4(5H)-One; O-Nitrobenzalrhodanin. Grade: 98%. CAS No. 6308-22-1. Molecular formula: C10H6N2O3S2. Mole weight: 266.3. | |
| Akt1 and Akt2-IN-1 | Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 and Akt2 with the IC50 of 3.5 nM and 42 nM respectively. It has potent and balanced activity. It is dependent on the PH-domain for Akt inhibition. It is selective for Akt1/2 over Akt3 and is highly selective over other members of the AGC family of kinases in vitro. It has potent inhibitory activity against Akt1 and Akt 2 in vivo in a mouse lung and efficacy in a tumor xenograft model. It has moderate activity in an hERG binding assay and is a substrate for human P-glycoprotein. It also shows good physical properties with a human plasma protein binding. Uses: Akt1 and akt2-in-1 has potent inhibitory activity against akt1 and akt 2 and efficacy in a tumor xenograft model. Synonyms: Akt Inhibitor 17; Akti_2008; Akti 2008; Akti2008; Akti-2008; Akt Inhibitor 17; Akt-Inhibitor-17; AktInhibitor17; 3-Phenyl-2-[4-[[4-[5-(2-pyridinyl)-1H-1,2,4-triazol-3-yl]-1-piperidinyl]methyl]phenyl]-1,6-Naphthyridin-5(6H)-one; Akti_2008; 3-phenyl-2-[4-[[4-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)piperidin-1-yl]methyl]phenyl]-6H-1,6-naphthyridin-5-one. Grade: >98%. CAS No. 893422-47-4. Molecular formula: C33H29N7O. Mole weight: 539.63. | |
| Akt-I-1 | AKT-I-1 is a selective and reversible inhibitor of Akt1. Synonyms: Akt-I-1 compound; AktI 1; N3-(7-Cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-N1,N1,2,2-tetramethyl-1,3-propanediamine. CAS No. 473382-39-7. Molecular formula: C22H30N6. Mole weight: 378.51. | |
| Akt-I-1,2 HCl | Akt-I-1,2 is a selective, non-ATP-competitive Akt1 and Akt2 inhibitor. Synonyms: Akt I 1,2 HCl; AktI1,2 HCl; Benzenemethanamine, alpha,alpha-dimethyl-4-(3-phenyl-2-quinoxalinyl)-, hydrochloride (1:1). CAS No. 473382-50-2. Molecular formula: C23H22ClN3. Mole weight: 375.90. | |
| AKTide-2T | AKTide-2T, a peptide substrate for Akt/PKB, has been found to act as an inhibitor and mimics the optimal phosphorylation sequence of Akt. Synonyms: AKTide-2T; 324029-01-8; ARKRERTYSFGHHA; AKOS024457090; PD079315. Grade: ≥95% by HPLC. CAS No. 324029-01-8. Molecular formula: C74H114N28O20. Mole weight: 1715.89. | |
| AKTide-2T TFA | AKTide-2T is a peptide substrate for Akt/PKB. It acts as an inhibitor and mimics the optimal phosphorylation sequence of Akt. Molecular formula: C76H115F3N28O22. Mole weight: 1829.89. | |
| AKT-IN-11 | AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC50 of 1.15 μM. Synonyms: (7R)-5-chloro-3-((1E,3E)-3,5-dimethylhepta-1,3-dien-1-yl)-7-hydroxy-7-methyl-2-(4-(trifluoromethoxy)benzyl)isoquinoline-6,8(2H,7H)-dione. Molecular formula: C27H27ClF3NO4. Mole weight: 521.96. | |
| AKT-IN-2 | AKT-IN-2 is a selective and orally bioavailable AKT inhibitor (IC50 = 5 nM for AKT1). Synonyms: AKT-IN-2; CHEMBL4129379; SCHEMBL1662401; QRULDXBXPXGMQS-QGZVFWFLSA-N; QRULDXBXPXGMQS-QGZVFWFLSA-O; BDBM50271964; AKOS040732404; HY-112148; CS-0043488; (R)-5-methyl-4-(4-(1-(2-(pyrrolidin-1-yl)ethyl)-4-(3,3,3-trifluoropropyl)-1H-imidazol-2-yl)piperidin-1-yl)-5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-one; 1295514-91-8. CAS No. 1295514-91-8. Molecular formula: C25H34F3N7O. Mole weight: 505.58. | |
| AKT-IN-3 | AKT-IN-3 is a potent and orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 also shows good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. Synonyms: 2-Piperidineacetamide, 5-[[[5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furanyl]carbonyl]amino]-4-(3,4-difluorophenyl)-N-methyl-, (2S,4S,5S)-. CAS No. 2374740-21-1. Molecular formula: C23H23Cl2F2N5O3. Mole weight: 526.36. | |
| AKT-IN-5 | AKT-IN-5 is an inhibitor of Akt1 and Akt2 with IC50s of 450 nM and 400 nM, respectively. CAS No. 1402608-05-2. Molecular formula: C23H20N4O2. Mole weight: 384.43. | |
| Akt Inhibitor IV | Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50 = 625 nM) and reduces phosphorylation of Akt at Ser473 and Thr308 in a dose-dependent manner. Synonyms: 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide. Grade: ≥95%. CAS No. 681281-88-9. Molecular formula: C31H27N4S·I. Mole weight: 614.6. | |
| AKT inhibitor VIII | Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity. It does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. It also prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice. Synonyms: AKT inhibitor VIII; AKT-inhibitor-VIII; AKT inhibitor-8; AKT-inhibitor-8; Akt-I 1,2; Akti-1/2. Sigma-A6730. 2H-Benzimidazol-2-one, 1,3-dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-. Grade: >98%. CAS No. 612847-09-3. Molecular formula: C34H29N7O. Mole weight: 551.64. | |
| AKT Kinase Inhibitor | AKT Kinase Inhibitor is a Akt Kinase Inhibitor. Synonyms: 2-Propyn-1-ol, 3-[2-(4-amino-1,2,5-oxadiazol-3-yl)-7-(3-aminopropoxy)-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-. Grade: >98%. CAS No. 842148-40-7. Molecular formula: C16H19N7O3. Mole weight: 357.37. | |
| Akt/SKG Substrate Peptide | Akt/SKG Substrate Peptide is a synthetic peptide and used as a substrate for Akt/PKB. It could not be phosphorylated by MAP kinase or p70 S6 kinase activated protein kinase-1. Synonyms: N5-(Diaminomethylene)-L-ornithyl-L-prolyl-N5-(diaminomethylene)-L-ornithyl-L-alanyl-L-alanyl-L-threonyl-L-phenylalanine. CAS No. 276680-69-4. Molecular formula: C36H59N13O9. Mole weight: 817.95. | |
| AL-034 | AL-034 is a Toll-like receptor 7 (TLR7) agonist in a phase I clinical trial for the treatment of HBV infections. Uses: The potential treatment of hbv infections. Synonyms: AL-034; AL 034; AL034. | |
| AL 082D06 | AL 082D06, also called as D-06, is a selective nonsteroidal antagonist of glucocorticoid receptor (GR) (Ki= 210 nM) without significant activity on AR, PR, MR and ER(Ki > 10 uM). AL 082D06 binds competitively with steroids, likely occupying a similar site. Synonyms: AL082D06; AL-082D06; AL 082D06; D-06. CAS No. 256925-03-8. Molecular formula: C23H24ClN3O2. Mole weight: 409.91. | |
| AL-3152 | AL-3152 is a aldehyde reductase inhibitors originated by Alcon. But clinical trials was discontinued for the treatment of Diabetic nephropathies, Diabetic neuropathies and Diabetic retinopathy. Uses: Diabetic nephropathies; diabetic neuropathies; diabetic retinopathy. Synonyms: AL-3152; AL 3152; AL3152; 2,7-difluoro-4-methoxy-Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione. Grade: 98%. CAS No. 126048-33-7. Molecular formula: C16H10F2N2O3. Mole weight: 316.62. | |
| AL-321 | AL-321 is a bio-active chemical, but no detailed information has been published yet. Synonyms: AL-321; AL321; AL 321; 5-((4-(2-methyl-2-phenylpropoxy)phenyl)methyl)- 2,4-Thiazolidinedione. Grade: 98%. CAS No. 74772-68-2. Molecular formula: C20H21NO3S. Mole weight: 355.45. | |
| AL 34662 | AL 34662 is a potent 5-HT2 receptor agonist with ocular hypotensive activity. Uses: Serotonin 5-ht2 receptor agonists. Synonyms: AL 34497; 1-((S)-2-aminopropyl)-1H-indazol-6-ol; 1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-. Grade: ≥98%. CAS No. 210580-75-9. Molecular formula: C10H13N3O. Mole weight: 191.2. | |
| AL-3803 | AL-3803, a spiro derivative, has been found to have some extent of biological activity in drug researches. Synonyms: AL-3803; AL 3803; AL3803; (-)-AL03152; AC1MIXPX; (-)-AL03152; Spiro(9H-fluorene-9,4'-imidazolidine)-2',5'-dione, 2,7-difluoro-4-methoxy-, (S)-; (9S)-2,7-difluoro-4-methoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione. Grade: 98%. CAS No. 145555-03-9. Molecular formula: C16H10F2N2O3. Mole weight: 316.26. | |
| AL 6598 | AL 6598 is the isopropyl ester prodrug of AL 6556, a PGD2 receptor agonist that binds to DP receptors with a Ki value of 3.2 μM and demonstrates an EC50 value of 0.80 μM in an in vitro functional assay. Synonyms: propan-2-yl 2-[(Z)-4-[(1R,2R,3R,5R)-5-chloro-2-[(3R)-3-cyclohexyl-3-hydroxypropyl]-3-hydroxycyclopentyl]but-2-enoxy]acetate. Grade: ≥97%. CAS No. 170291-06-2. Molecular formula: C23H39ClO5. Mole weight: 431. | |
| AL 8697 | AL 8697 is an effective and selective p38α inhibitor and has been found to exhibit some antiinflammatory activities. Synonyms: AL 8697; AL8697; AL-8697; N-Cyclopropyl-3-[3-(1,1-dimethylethyl)-6,8-difluoro-1,2,4-triazolo[4,3-a]pyridin-7-yl]-5-fluoro-4-methylbenzamide. Grade: ≥98% by HPLC. CAS No. 1057394-06-5. Molecular formula: C21H21F3N4O. Mole weight: 402.41. | |
| AL 8810 | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL-8810 produced a concentration-dependent shift in the fluprostenol concentration-response curve, without significantly decreasing the maximal response. AL-8810 has weak agonist potency with EC50 of 261 +/- 44 nM (n = 3) and Emax = 19% (relative to the full FP receptor agonist cloprostenol) in A7r5 cells and EC50 of 186 +/- 63 nM (n = 3) and Emax = 23% in 3T3 fibroblasts. Uses: Prostaglandin antagonists. Synonyms: AL-8810; 246246-19-5; AL 8810; AL8810; (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoic acid; 12QE8J6004; 5-Heptenoic acid, 7-((1R,2R,3S,5S)-2-((1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl)-3-fluoro-5-hydroxycyclopentyl)-, (5Z)-; 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, (5Z)-; 5-Heptenoic acid, 7-((1R,2R,3S,5S)-2-((1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propenyl)-3-fluoro-5-hydroxycyclopentyl)-, (5Z)-. Grade: ≥98%. CAS No. 246246-19-5. Molecular formula: C24H31O4F. Mole weight: 402.5. | |
| AL 8810 isopropyl ester | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL 8810 isopropyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost and Travoprost. Synonyms: AL 8810 isopropyl ester; Propan-2-yl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoate; 5-Heptenoic acid, 7-[(1R,2R,3S,5S)-2-[(1E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxy-1-propen-1-yl]-3-fluoro-5-hydroxycyclopentyl]-, 1-methylethyl ester, (5Z)-; HMS3648C21; AKOS025294879; SR-01000946200; SR-01000946200-1; 9alpha, 15R- dihydroxy- 11beta- fluoro- 15- (2, 3- dihydro- 1H- inden- 2- yl)- 16, 17, 18, 19, 20- pentanor- prosta- 5Z, 13E- dien- 1- oic acid, isopropyl ester. Grade: ≥98%. CAS No. 208114-93-6. Molecular formula: C27H37FO4. Mole weight: 444.6. | |
| AL 8810 methyl ester | AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL 8810 methyl ester is a lipid soluble, esterified prodrug form of AL 8810 analogous to the commonly used therapeutic intraocular prostaglandin compounds such as Latanoprost and Travoprost. Synonyms: AL 8810 methyl ester; 1176541-11-9; methyl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-fluoro-5-hydroxycyclopentyl]hept-5-enoate; CHEBI:186084; DTXSID001347566; methyl (Z)-7-[(1R,2R,3S,5S)-2-[(E,3R)-3-(2,3-dihydro-1H-inden-2-yl)-3-hydroxyprop-1-enyl]-3-luoro-5-hydroxycyclopentyl]hept-5-enoate. Grade: ≥98%. CAS No. 1176541-11-9. Molecular formula: C25H33FO4. Mole weight: 416.5. | |
| Ala (3-CN)5-Oxytocin | Ala (3-CN)5-Oxytocin is an impurity of Oxytocin, which is a mammalian neurohypophysial hormone used as a vasodilator agent. Synonyms: [5-(3-Cyanoalanine)]oxytocin; [Ala(3-CN)5] Oxytocin; L-Cystyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-β-3-cyano-alanyl-L-cystyl-L-leucyl-L-prolyl-L-glycinamide (disulfide bridge between cysteines); Oxytocin, 5-(3-cyano-L-alanine)-; H-Cys-Tyr-Ile-Gln-Ala(3-CN)-Cys-Pro-Leu-Gly-NH2 (Disulfide bridge: Cys1-Cys6); Oxytocin EP Impurity F; 5-(3-Cyano-L-alanine)oxytocin. Grade: ≥95%. CAS No. 87590-89-4. Molecular formula: C43H64N12O11S2. Mole weight: 989.18. | |
| Alachlor-d13 | A labelled Alachlor. Synonyms: 2-Chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide-d13; 2-Chloro-2',6'- diethyl-N-(methoxymethyl)acetanilide-d13; 2-Chloro-2',6'-diethyl-N-methoxy- methylacetanilide-d13. Grade: > 95%. CAS No. 1015856-63-9. Molecular formula: C14H7ClNO2D13. Mole weight: 282.85. | |
| a-Lactose monohydrate | It is widely used as a carrier, diluent, and flow aid in dry powder inhalation formulations. Synonyms: O-b-D-galactopyranosyl-(1-4)-a-D-glucopyranose monohydrate; α-D-Glucopyranose, 4-O-β-D-galactopyranosyl-, hydrate (1:1); 4-O-β-D-Galactopyranosyl-α-D-glucopyranose monohydrate; Aeroflo 20; GranuLac 200; Inhalac 230; Lactochem; Zeparox; α-D-Lactose monohydrate; α-Lactose monohydrate. Grade: ≥98%. CAS No. 5989-81-1. Molecular formula: C12H22O11.H2O. Mole weight: 360.31. | |
| Aladorian | Aladorianis is a ryanodine receptor calcium release channel modulator. It is an antiarrhythmic agent. Clinical development for Chronic heart failure and Ventricular tachycardia was discontinued. Uses: Chronic heart failure; ventricular tachycardia. Synonyms: 2,3-Dihydro-7-methoxy-α-oxo-1,4-benzothiazepine-4(5H)-acetic Acid; ARM036; ARM-036; ARM 036; S36; S44121-1; Aladorian; Aladorian; S 36; S 44121-1. Grade: 98%. CAS No. 865433-00-7. Molecular formula: C12H13NO4S. Mole weight: 267.30. | |
| Alafosfalin | Alafosfalin is an inhibitor of cell wall biosynthesis. Alaphosphin is used as a selection agent for isolation of Salmonella and as a dipeptide mimetic antibacterial agent. Synonyms: Alaphosphin; n-[(1r)-1-phosphonoethyl]-l-alaninamide; (1R)-1-(L-Alanylamino)ethylphosphonic acid; Alafosfalino; L-Alanyl-L-1-aminoethylphosphonic Acid; Ro 03-7008. CAS No. 60668-24-8. Molecular formula: C5H13N2O4P. Mole weight: 196.14. | |
| Ala-Leu-Ala-Leu Daunorubicin Hydrochloride | Ala-Leu-Ala-Leu Daunorubicin Hydrochloride is an impurity of Daunorubicin, which is an anthracycline antibiotic used in the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. Uses: Daunorubicin linked to proteins. Synonyms: (8S-cis)-8-Acetyl-10-[[3-[[N-[N-(N-L-alanyl-L-leucyl)-L-alanyl]-L-leucyl]amino]-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Monohydrochloride; Ala-Leu-Ala-Leu-DNR; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-[(L-alanyl-L-leucyl-L-alanyl-L-leucyl)amino]-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride (1:1). Grade: ≥95%. CAS No. 76582-70-2. Molecular formula: C45H62ClN5O14. Mole weight: 932.45. | |
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