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A metabolite from the culture medium of Leuconostoc mesenteroides. Synonyms: (S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid. Grades: 95%. CAS No. 23508-35-2. Molecular formula: C9H10O4. Mole weight: 182.17.
S-4-Methoxybenzyl-L-penicillamine is a derivative of D-Penicillamine, which is a penicillin metabolite used in the treatment of Wilson's disease, Cystinuria, Scleroderma and arsenic poisoning. Synonyms: L-Pen(pMeOBzl)-OH; H-β,β-Dimethyl-L-Cys(pMeOBzl)-OH; H-Pen(Mob)-OH; 3-[[(4-Methoxyphenyl)methyl]thio]-L-valine; (R)-2-Amino-3-((4-methoxybenzyl)thio)-3-methylbutanoic acid; 3-[(4-Methoxybenzyl)sulfanyl]-L-valine; L-Valine, 3-[[(4-methoxyphenyl)methyl]thio]-. Grades: ≥95%. CAS No. 387868-34-0. Molecular formula: C13H19NO3S. Mole weight: 269.34.
S-4-Methylbenzyl-L-penicillamine is a methylbenzyl L analogue of D-Penicillamine, which is Penicillin metabolite used in the treatment of Wilson's disease, Cystinuria, Scleroderma and arsenic poisoning. Synonyms: 3-[[(4-Methylphenyl)methyl]thio]-L-valine; (R)-2-Amino-3-methyl-3-((4-methylbenzyl)thio)butanoic acid; L-Valine, 3-[[(4-methylphenyl)methyl]thio]-; 3-[(4-Methylbenzyl)sulfanyl]-L-valine; H-β,β-Dimethyl-L-cys(pmebzl)-OH. Grades: 98%. CAS No. 1039102-11-8. Molecular formula: C13H19NO2S. Mole weight: 253.36.
S-632-B1
S-632-B1 is an antitumor and antifungal antibiotic produced by Streptomyces hygroscopicus S-632. It inhibits Saccharomyces cerevisiae with MIC of 0.78 μg/mL. Synonyms: Antibiotic S 632-B1; S 632B(sub 1); Antibiotic S 632B(sub 1). CAS No. 121995-32-2. Molecular formula: C17H25NO5. Mole weight: 323.4.
S-632-B2
S-632-B2 is an antitumor and antifungal antibiotic produced by Streptomyces hygroscopicus S-632. It inhibits Saccharomyces cerevisiae with MIC of 0.78 μg/mL. It activity is weaker than that of S-632-B1. Synonyms: Antibiotic S 632-B2; S 632B(sub 2); Antibiotic S 632B(sub 2). Molecular formula: C17H25NO5. Mole weight: 323.4.
An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin; has pronounced activity against gram positive bacteria and chlamydia trachomatis; inhibits transcription from the promoter of GRP78; appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 10-[[4-(acetylamino)-2,4,6-trideoxy-3-C-methylhexopyranosyl]oxy]-4-[[O-2,6-dideoxyhexopyranosyl-(1?4)-O-2,6-dideoxy-3-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)hexopyranosyl-(1?4)-2,6-dideoxyhexopyranosyl]oxy]-15-ethyl-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,3,7,9,11,20a-hexamethyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione. Grades: >95% by HPLC. CAS No. 158475-32-2. Molecular formula: C67H101NO20. Mole weight: 1240.51.
Saccharocarcin B
An unusual tetronic acid structurally related to kijanimicin, chlorothricin, tetrocarcin and versipelostatin; has pronounced activity against gram positive bacteria and chlamydia trachomatis; inhibits transcription from the promoter of GRP78; appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: 10-[[4-(acetylamino)-2,4,6-trideoxy-3-C-methylhexopyranosyl]oxy]-4-[[O-2,6-dideoxyhexopyranosyl-(1?4)-O-2,6-dideoxy-3-O-(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)hexopyranosyl-(1?4)-2,6-dideoxyhexopyranosyl]oxy]-2,3,4,4a,6a,9,10,12a,15,16,20a,20b-dodecahydro-21-hydroxy-1,3,7,9,11,20a-hexamethyl-15-propyl-18H-16a,19-metheno-16aH-benzo[b]naphth[2,1-j]oxacyclotetradecin-18,20(1H)-dione. Grades: >99% by HPLC. CAS No. 158475-33-3. Molecular formula: C68H103NO20. Mole weight: 1254.54.
Saccharocin
Saccharocin is produced by the strain of Saccharopolyspora sp. AC-3440. It is effective against gram-positive and negative bacteria, and also against aminoglycoside antibiotic-resistant bacteria. Synonyms: KA-5685. CAS No. 86630-31-1. Molecular formula: C21H40N4O12. Mole weight: 540.56.
Cas No. 35899-53-7. Molecular formula: C13H18N6O5S. Mole weight: 370.38.
Safracin A
Safracin A is produced by the strain of Pseudomonas fluorescens A22 (IFO 14128). It has anti-gram-positive bacteria, gram-negative bacteria and anti-tumor effect. Synonyms: Y-16760; 2-Amino-N-[(1-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,7,9,10,13,14,14a,15-octahydro-5H-6,15-epiminoisoquinolino[3,2-b][3]benzazocin-9-yl)methyl]propanimidic acid. Grades: >98%. CAS No. 87578-98-1. Molecular formula: C28H36N4O6. Mole weight: 524.61.
Safracin B
Safracin B is a new antibiotic from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B exhibits broad spectrum antimicrobial and strong antitumor activities. Synonyms: Antibiotic EM 5519; Antibiotic Y 16482&alpha. Grades: ≥85% (HPLC). CAS No. 87578-99-2. Molecular formula: C28H36N4O7. Mole weight: 540.61.
Saframycin A
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. Saframycin A also has weak activity against gram-negative bacteria and mycobacteria. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.0056 μmol/L. Synonyms: (-)-saframycin A; 21-Cyanosaframycin-B; N-[[(6S)-7α-Cyano-1,5,6,7,9,10,13,14,14aα,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6S,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. Grades: 98%. CAS No. 66082-27-7. Molecular formula: C29H30N4O8. Mole weight: 562.57.
Saframycin B
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: Propanamide, N-((1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (6S-(6-alpha,9-beta,14a-alpha,15-alpha))-; N-[[(6S)-1,5,6,7,9,10,13,14,14aα,15-Decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6S,9R,14aS,15R)-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-28-8. Molecular formula: C28H31N3O8. Mole weight: 537.56.
Saframycin C
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. Synonyms: Propanamide, N-((1,5,6,7,9,10,13,14,14a,15-decahydro-2,5,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (5S-(5-alpha,6-alpha,9-beta,14a-alpha,15-alpha))-; N-[[(5S)-1,5,6,7,9,10,13,14,14aα,15-Decahydro-2,5α,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6α,15α-epimino-4H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(5S,6R,9R,14aS,15R)-1,5,6,7,9,10,13,14,14a,15-decahydro-2,5,11-trimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-29-9. Molecular formula: C29H33N3O9. Mole weight: 567.59.
Saframycin D
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: N-[[(6R)-6,7,9,10,13,14,14aα,15-Octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-((6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (6R-(6-alpha,9-beta,14a-alpha,15-alpha))-. CAS No. 66082-30-2. Molecular formula: C28H31N3O9. Mole weight: 553.56.
Saframycin E
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It also has weak activity against mycobacteria. Synonyms: Propanamide, N-[[(5S,6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4,5-trihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-. CAS No. 66082-31-3. Molecular formula: C28H33N3O9. Mole weight: 555.58.
Saframycin F
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.59 μmol/L. Synonyms: 21-Cyanosaframycin D; N-[[(6R)-7α-Cyano-6,7,9,10,13,14,14aα,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin-9β-yl]methyl]-2-oxopropionamide; Propanamide, N-[[(6R,7R,9R,14aS,15R)-7-cyano-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-[(7-cyano-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-5,10,13-trioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-oxo-, [6R-(6a,7a,9b,14aa,15a)]-; (+)-Saframycin F. CAS No. 92569-03-4. Molecular formula: C29H30N4O9. Mole weight: 578.57.
Saframycin G
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.03 μmol/L. Synonyms: 14-Hydroxysaframycin A; Propanamide, N-[[(5S,6R,7R,9R,14aS,15R)-7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxo-; Propanamide, N-[(7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-oxo-, [5S-(5a,6a,7a,9b,14aa,15a)]-; (-)-Saframycin G; Propanamide, N-((7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-5-hydroxy-2,11-dimethoxy-3,12,16-trimethyl-1-4-10,13-tetraoxo-6,15-imino-4H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-2-oxo-, (5S-(5alpha, 6alpha, 7alpha, 9beta, 14aalpha, 15alpha))-. CAS No. 92569-02-3. Molecular formula: C29H30N4O9. Mole weight: 578.57.
Saframycin H
It is produced by the strain of Str. lavendulae No 314. It has the effect of anti-Gram-positive bacteria, and Saframycin A has the strongest antibacterial activity. It has the effect of inhibiting mouse lymphocyte L-1210 with ID50 of 0.033 μmol/L. Synonyms: 25-Dihydro-25-beta-ketopropylsaframycin A; Pentanamide, N-[(7-cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-2-hydroxy-2-methyl-4-oxo-, (1R,2S,10R,13S)-. CAS No. 92569-01-2. Molecular formula: C32H36N4O9. Mole weight: 620.65.
Saframycin Mx1
It is produced by the strain of Myxococcus xanthus. It has anti-gram-positive bacteria and gram-negative bacteria effects. Synonyms: Saframycin Mx-1; Propanamide, 2-amino-N-((6,7,9,10,13,14,14a,15-octahydro-1,4,7-trihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino(3,2-b)(3)benzazocin-9-yl)methyl)-, (5S-(5-alpha,6-beta,7-alpha,9-beta(R*),14a-alpha,15-beta))-; 2-Amino-N-[[[(5S)-6,7,9,10,13,14,14aα,15-octahydro-1,4,7α-trihydroxy-2,5α,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin]-9β-yl]methyl]propionamide; Propanamide, 2-amino-N-[[(5S,6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4,7-trihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-. CAS No. 113036-78-5. Molecular formula: C29H38N4O9. Mole weight: 586.63.
Saframycin Mx2
It is produced by the strain of Myxococcus xanthus. It has anti-gram-positive bacteria and gram-negative bacteria effects. Synonyms: (S)-2-Amino-N-[[[(5S)-6,7,9,10,13,14,14aα,15-octahydro-1,4-dihydroxy-2,5α,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6α,15α-epimino-5H-isoquino[3,2-b][3]benzazocin]-9β-yl]methyl]propionamide; Saframycin Mx-2; Propanamide, 2-amino-N-[[(5S,6R,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-; Propanamide, 2-amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,4-dihydroxy-2,5,11-trimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]-, [5S-[5a,6a,9b(R*),14aa,15a]]-. CAS No. 113036-79-6. Molecular formula: C29H38N4O8. Mole weight: 570.63.
Sakyomicin A
It is a benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. In vivo, 10 mg/kg of Sakyomicin A had no effect against sarcoma 180A and leukemia P338 cells. Synonyms: Benz[A]anthracene-1,7,12(2H)-trione, 3,4,4A,12B-tetrahydro-2,3,4A,8-tetrahydroxy-3-methyl-12B-[[2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-, (2S,3R,4as,12br)-; SKM; (2S)-3,4,4a,12b-Tetrahydro-2β,3α,4aβ,8-tetrahydroxy-3-methyl-12bβ-[[(2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]benz[a]anthracene-1,7,12(2H)-trione. CAS No. 86413-75-4. Molecular formula: C25H26O10. Mole weight: 486.47.
Sakyomicin B
It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. Synonyms: (2S)-3, 4, 4a, 12b-Tetrahydro-2β, 3α, 4aβ, 8, 12bβ-pentahydroxy-3-methylbenz[a]anthracene-1, 7, 12(2H)-trione; Benz(a)anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, (2S-(2-alpha,3-beta,4a-alpha,12b-alpha))-; Antibiotic SEN 136A; Antibiotic WP 3688-1; Antibiotic PD 116198; (+)-Sakyomicin B. CAS No. 86470-27-1. Molecular formula: C19H16O8. Mole weight: 372.33.
Sakyomicin C
It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria and mycobacteria. In vivo, 6 mg/kg of Sakyomicin C had no effect against sarcoma 180A and leukemia P338 cells. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-3,4a,8-trihydroxy-3-methyl-12b-[[(2R,5R,6R)-tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl]oxy]-, (3R,4aS,12bR)-; Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,12b-tetrahydro-3,4a,8-trihydroxy-3-methyl-12b-[(tetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)oxy]-, [3R-[3a,4ab,12bb(2R*,5R*,6R*)]]-. CAS No. 86413-76-5. Molecular formula: C25H26O9. Mole weight: 470.47.
Sakyomicin D
It is a Benzoquinone antibiotic produced by the strain of Nocardia sp. M-53. It has activity against gram-positive bacteria. Synonyms: Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,5,6,12b-hexahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, (2S,3R,4aR,12bR)-; Benz[a]anthracene-1,7,12(2H)-trione,3,4,4a,5,6,12b-hexahydro-2,3,4a,8,12b-pentahydroxy-3-methyl-, [2S-(2a,3b,4aa,12ba)]-. CAS No. 86413-77-6. Molecular formula: C19H18O8. Mole weight: 374.34.
Salfredin A3
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-53-3. Molecular formula: C18H19NO9. Mole weight: 393.30.
Salfredin A4
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-54-4. Molecular formula: C15H15NO7. Mole weight: 321.28.
Salfredin A7
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-55-5. Molecular formula: C16H17NO7. Mole weight: 335.31.
Salfredin B11
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. Synonyms: 6H-Furo(3,4-g)-1-benzopyran-6-one, 2,8-dihydro-5-hydroxy-2,2-dimethyl-; 2,8-Dihydro-5-hydroxy-2,2-dimethyl-6H-furo(3,4-g)-1-benzopyran-6-one; 9-Hydroxy-6,6-dimethyl-3,6-dihydro-2,5-dioxa-cyclopenta[b]naphthalen-1-one. Grades: 98% by HPLC. CAS No. 165467-63-0. Molecular formula: C13H12O4. Mole weight: 232.23.
Salfredin C1
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-56-6. Molecular formula: C13H11NO6. Mole weight: 277.23.
Salfredin C2
It is an aldose reductase inhibitor produced by the strain of Crucibulum sp. RF-3817. CAS No. 139542-57-7. Molecular formula: C15H13NO8. Mole weight: 335.26.