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Pyracrimycin A
Pyracrimycin A is an antibacterial antibiotic produced by Str. eridani. It has activity against gram-positive bacteria, gram-negative bacteria and mycobacteria. Synonyms: Cyclamidomycin; Desdanine. Grades: >98%. CAS No. 35663-85-5. Molecular formula: C7H10N2O. Mole weight: 138.17.
Pyralomicin 1a
Pyralomicin 1a is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139636-03-6. Molecular formula: C20H19Cl2NO7. Mole weight: 456.27.
Pyralomicin 1b
Pyralomicin 1b is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139636-04-7. Molecular formula: C20H19Cl2NO7. Mole weight: 456.27.
Pyralomicin 1c
Pyralomicin 1c is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139635-99-7. Molecular formula: C19H17Cl2NO7. Mole weight: 442.25.
Pyralomicin 1d
Pyralomicin 1d is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139635-98-6. Molecular formula: C19H16Cl3NO7. Mole weight: 476.69.
Pyralomicin 2a
Pyralomicin 2a is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139636-00-3. Molecular formula: C19H19Cl2NO8. Mole weight: 460.26.
Pyralomicin 2b
Pyralomicin 2b is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139635-97-5. Molecular formula: C19H19Cl2NO8. Mole weight: 460.26.
Pyralomicin 2c
Pyralomicin 2c is an antibiotic produced by Actinomadura spiralis MI 178-34F18. Antibacterial activity. CAS No. 139636-01-4. Molecular formula: C18H17Cl2NO8. Mole weight: 446.23.
Pyrazinamide
Pyrazinamide is a pyrazine that is used therapeutically as an antitubercular agent. It is a prodrug that stops the growth of Mycobacterium tuberculosis. It is thought to inhibit the enzyme fatty acid synthase (FAS) I, which is required by the bacterium to synthesise fatty acids although this has been discounted. It binds to the ribosomal protein S1 (RpsA) and inhibits trans-translation. Synonyms: Pyrazinecarboxamide; Pyrazinoic acid amide; 2-Pyrazinecarboxamide; Zinamide; Aldinamide; Tebrazid; Pirazinamid; Unipyranamide; Farmizina; Eprazin; Novamid. Grades: >98%. CAS No. 98-96-4. Molecular formula: C5H5N3O. Mole weight: 123.11.
Pyrazomycin B
Pyrazomycin B is an antibiotic produced by Str. candidus NRRL 3601. Pyrazomycin is a competitive inhibitor of pyrimidine nucleoside metabolism. Synonyms: 1H-Pyrazole-3-carboxamide, 4-hydroxy-5-alpha-D-ribofuranosyl-; 5-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1H-pyrazole-3-carboxamide. CAS No. 41855-21-4. Molecular formula: C9H13N3O6. Mole weight: 259.22.
Pyrenophorin
Pyrenophorin is a macrocyclic polylactone antibiotic produced by Pyrenophora averae NH7. It has activity against Gram-positive bacteria, mycobacteria, filamentous fungi, yeast-like fungi and Trichomonas. Synonyms: 1,9-Dioxacyclohexadeca-3,11-diene-2,5,10,13-tetrone, 8,16-dimethyl-, (8R-(3E,8R*,11E,16R*))-. CAS No. 5739-85-5. Molecular formula: C16H20O6. Mole weight: 308.33.
Pyrenophorol
A simple macrocyclic dilactone produced by a number of species of pathogenic fungi, including byssochlamys, stenphyllum, alternaria and drechslera. It exhibits antibacterial, herbicidal and anthelmintic properties. It is a weak inhibitor of propyl endopeptidases and can inhibit seed germination. Synonyms: (-)-Pyrenophorol; Helmidiol; (5S,8R,13S,16R)-(-)-pyrenophorol. Grades: >95% by HPLC. CAS No. 22248-41-5. Molecular formula: C16H24O6. Mole weight: 312.36.
Pyridindolol K1
Pyridindolol K1 is an alkaloid antibiotic produced by Str. sp. K93-0711. Synonyms: Pyridoindole K1. Molecular formula: C18H18N2O5. Mole weight: 342.35.
Pyridindolol K2
Pyridindolol K2 is an alkaloid antibiotic produced by Str. sp. K93-0711. Pyridindolol K2 can inhibit the adhesion of HL-60 cells. Synonyms: Pyridoindole K2. Molecular formula: C16H16N2O4. Mole weight: 300.31.
Pyridomycin
Pyridomycin is an ester peptide antibiotic produced by Str. pyridomyceticus. It has strong anti-mycobacterial activity and weak anti-gram-negative bacteria activity. Synonyms: Erizomycin. Grades: >95% by HPLC. CAS No. 18791-21-4. Molecular formula: C27H32N4O8. Mole weight: 540.56.
Pyridomycin Hydrochloride
Pyridomycin Hydrochloride is an ester peptide antibiotic produced by Str. pyridomyceticus. It has strong anti-mycobacterial activity and weak anti-gram-negative bacteria activity. CAS No. 1402-18-2. Molecular formula: C27H33ClN4O8. Mole weight: 577.02.
Pyripyropene A
Pyripyropene A is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 58 nmol/L. Synonyms: (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate; (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(Acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,11,12,12a,12b-dodecahydrobenzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate. Grades: ≥95%. CAS No. 147444-03-9. Molecular formula: C31H37NO10. Mole weight: 583.62.
Pyripyropene B
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nmol/L. Synonyms: 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one,3,6-bis(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-4-[(1-oxopropoxy)methyl]-9-(3-pyridinyl)-,(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-. CAS No. 151519-44-7. Molecular formula: C32H39NO10. Mole weight: 597.65.
Pyrisulfoxin A
Pyrisulfoxin A is an antibiotic produced by Streptomyces callfornicus BS-75. CAS No. 187337-07-1. Molecular formula: C13H13N3O3S. Mole weight: 291.33.
Pyrisulfoxin B
Pyrisulfoxin B is an antibiotic produced by Streptomyces callfornicus BS-75. Molecular formula: C13H11N3O2S. Mole weight: 273.31.
Pyrocoll
Pyrocoll is a compound produced by Streptomyces sp. AK409 with antiparasitic and antitumor effects. It has activity against Arthrobacter bacteria, with an MIC of 1-10 μg/mL. It has a moderate anti-plasmodium effect, and its IC50 for Plasmodium facipaum is 1.19 μg/mL (standard chloroquine is 0.078 μg/mL). It also inhibits the growth of tumor cells. The IC50 pairs of HM02, HepG2 and MCF 7 cells are 0.23, 0.42 and 2.2 μg/mL, respectively. Grades: ≥95%. CAS No. 484-73-1. Molecular formula: C10H6N2O2. Mole weight: 186.17.
Pyrrolomycin A
Pyrrolomycin A is a pyrrole antibiotic produced by Adinosporangium vitaminophilum SF-2080. It has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity. Synonyms: 2,3-Dichloro-4-nitropyrrole. CAS No. 79763-01-2. Molecular formula: C4H2Cl2N2O2. Mole weight: 180.97.
Pyrrolomycin E
Pyrrolomycin E is a pyrrole antibiotic produced by Adinosporangium vitaminophilum SF-2080. It has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity. CAS No. 87376-16-7. Molecular formula: C10H5Cl3N2O3. Mole weight: 307.52.
Pyrrolosporin A
Pyrrolosporin A is an antibiotic produced by Micromonospora sp. C39217-R1097. It has weak anti-Gram-negative bacteria activity. Molecular formula: C44H54Cl2N2O10. Mole weight: 841.81.
Pyrromycin
It is an antibiotic against gram-positive bacteria originally isolated from Str. sp. DOA 1205. Synonyms: NSC-267229; Antibiotic MA-144T2; (1R-(1alpha,2beta,4beta))-2-Ethyl-1,2,3,4,6,11-hexahydro-2,5,7,10-tetrahydroxy-6,11-dioxo-4-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-1-naphthacenecarboxylic acid, methyl ester. CAS No. 668-17-7. Molecular formula: C30H35NO11. Mole weight: 585.60.
Pyrronamycin A
Pyrronamycin A is produced by the strain of Streptomyces sp. KY11768. It has antibacterial activity against gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella. Molecular formula: C23H29N11O5. Mole weight: 539.55.
Pyrronamycin B
Pyrronamycin B is produced by the strain of Streptomyces sp. KY11768. It has antibacterial activity against gram-positive and negative bacteria such as Staphylococcus aureus, enterococcus, Escherichia coli, Klebsiella pneumoniae, Proteus, Shigella and Salmonella. It also has anti-tumor activity. Molecular formula: C23H29N11O6. Mole weight: 555.55.
Quadrilineatin
It is originally isolated from Asp. quadrilineatus NRRL 521, NRRL 201, SM 200, SM-297, GA317. Quadrilineatin has antifungal and bacterial effects. Synonyms: 5-Hydroxy-3-methoxy-4-methylbenzene-1,2-dicarbaldehyde; 3-Methoxy-4-methyl-5-hydroxyphthalaldehyde. CAS No. 642-27-3. Molecular formula: C10H10O4. Mole weight: 194.18.
Quadrone
It is an unusual sesquiterpene metabolite isolated from aspergillus terreus. It exhibits antitumor activity. Synonyms: (-)-Quadrone; [3aS-(3aα, 5aβ, 6α, 8aα, 8bα)]-Octahydro-10, 10-dimethyl-6, 8b-ethano-8bH-cyclopenta[de]-2-benzopyran-1, 4-dione; (3aS,5aR,6R,8aR,8bR)-octahydro-10,10-dimethyl-6,8b-ethano-8bH-cyclopenta[de]-2-benzopyran-1,4-dione. Grades: >98% by HPLC. CAS No. 66550-08-1. Molecular formula: C15H20O3. Mole weight: 248.32.
Queenslandon
Queenslandon is produced by the strain of Chrysosporium queenslandicum IFM 51121. It has moderate anti-streptomyces, penicillium, Penicillium, Aspergillus fumigatus, aspergillus flavus and other fungal activities. And it has no effect on bacteria. Molecular formula: C20H26O8. Mole weight: 394.41.
Questinol
Questinol is obtained from the cultures of the fungus Talaromyces stipitatus KUFA 0207. It can inhibit the production of NO, PGE2 and pro-inflammatory cytokines, including TNF-α, IL-1β and IL-6. It displays anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. It also shows remarkable anti-obesity activity. Synonyms: 1,6-Dihydroxy-3-(hydroxymethyl)-8-methoxy-9,10-anthracenedione; 9,10-Anthracenedione, 1,6-dihydroxy-3-(hydroxymethyl)-8-methoxy-; Omega-Hydroxymethylemodin. Grades: 98.0%. CAS No. 35688-09-6. Molecular formula: C16H12O6. Mole weight: 300.26.
Quinaldopeptin
It is a symmetrical, cyclic decapeptide from an amycolatopsis sp. This is a bis-intercalator of DNA. It exhibits strong in vitro antimicrobial and cytotoxic activity. It significantly prolongs the survival time of mice inoculated with a murine tumour, and also shows weak nematocidal activity. It is related to the luzopeptins and sandramycin. Synonyms: Antibiotic BMY 28662; Antibiotic BU 3845T; BMY 28662; BU 3845T. Grades: >95% by HPLC. CAS No. 130743-07-6. Molecular formula: C62H78N14O14. Mole weight: 1243.37.
Quinocarcin
Quinocarcin is originally isolated from Streptomyces melanovinaceus. It has anti-gram-positive bacteria and Klebsiella pneumoniae activity, and also has anti-mouse leukemia P388 effect. Synonyms: Antibiotic DC 52; DC 52; 11-Methoxy-12-methyl-2a,3,4,5,6,6a,7,11b-octahydro-1H-3,6-epimino-2-oxa-11c-azanaphtho[1,2,3-cd]azulene-5-carboxylic acid; (2aR,3S,5R,6R,6aS,11bR)-2a,3,4,5,6,6a,7,11b-Octahydro-11-methoxy-12-methyl-3,6-imino-1H-2-oxa-11c-azanaphth[1,2,3-cd]azulene-5-carboxylic Acid. CAS No. 84573-33-1. Molecular formula: C18H22N2O4. Mole weight: 330.38.
Quinocitrinine B
Quinocitrinine B is produced by the strain of Penicillum citrinum Thom 1910. It has moderate anti-gram positive and negative bacterial and fungal activity. And it also shows moderate antiproliferative activity to L-929, K-562 and HeLa cells. Synonyms: (3R)-3-[(1S)-1-Methylpropyl]-4-methyl-6-hydroxy-4-azonia-2,3-dihydro-1H-pyrrolo[3,4-b]quinoline-1-one. Molecular formula: C16H19N2O2. Mole weight: 271.33.
Quinolactacin A
Quinolactactin A is a quinolone fungal metabolite that inhibits TNF production induced by LPS in murine peritoneal macrophages. Synonyms: (3S)-2,3-dihydro-4-methyl-3-(1-methylpropyl)-1H-pyrrolo[3,4-b]quinoline-1,9(4H)-dione. Grades: >95%. CAS No. 319917-25-4. Molecular formula: C16H18N2O2. Mole weight: 270.33.
Quinolactacin A1
The dominant analogue of a family of quinolone metabolites produced by penicillium citrinum; inhibit acetylcholinesterase and TNF production. Synonyms: (+)-Quinolactacin A1; (3R)-2,3-dihydro-4-methyl-3-[(1S)-1-methylpropyl]-1H-pyrrolo[3,4-b]quinoline-1,9(4H)-dione. Grades: >95% by HPLC. CAS No. 815576-68-2. Molecular formula: C16H18N2O2. Mole weight: 270.33.
Quinolactacin A2
Quinolactacin A2 is the dominant analogue of a family of quinolone metabolites produced by penicillium citrinum, inhibits acetylcholinesterase and TNF production. Synonyms: ZINC14684865. Molecular formula: C16H18N2O2. Mole weight: 270.33.
Quinomycin B
Quinomycin B is originally isolated from Str. sp. 732. It has a strong effect on gram-positive bacteria and HeLa cells, and also on some gram-negative bacteria. It also has a protective effect on mice inoculated with poliovirus. Synonyms: BRN 1071167; Quinomycin A,4-(N-methylalloisoleucine)-8-(N-methylalloisoleucine). CAS No. 13602-52-3. Molecular formula: C53H68N12O12S2. Mole weight: 1129.31.
Quinomycin C
Quinomycin C is originally isolated from Str. sp. 732. It has a strong effect on gram-positive bacteria and HeLa cells, and also on some gram-negative bacteria. It also has a protective effect on mice inoculated with poliovirus. Synonyms: Antibiotic U 48160; BRN 1071168. Grades: >98%. CAS No. 11001-74-4. Molecular formula: C55H72N12O12S2. Mole weight: 1157.36.
Quinupristin
Quinupristin is an antibiotic and usually used in combination with dalfopristin (The trade name is Synercid). It is active against Gram-positive bacteria through inhibiting protein synthesis of the cells, but not active against Gram-negative bacteria, so it needs to be given in combination with other antibacterials for mixed infections which also involve Gram-negative organisms. Uses: Semisynthetic depsipeptide type i streptogramin. an antibacterial agent. Synonyms: N-((6R, 9S, 10R, 13S, 15aS, 18R, 22S, 24aS)-22-(4-(dimethylamino)benzyl)-6-ethyl-10, 23-dimethyl-5, 8, 12, 15, 17, 21, 24-heptaoxo-13-phenyl-18-((((S)-quinuclidin-3-yl)thio)methyl)docosahydro-12H-pyrido[2, 1-f]pyrrolo[2, 1-l][1]oxa[4, 7, 10, 13, 16]pentaazacyclononadecin-9-yl)-3-hydroxypicolinamide; RP68888; RP57669; Antibiotic RP 57669; 4-[4-(Dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S,5R)-5-[[[(3S)-1-azabicyclo[2.2.2]oct-3-yl]thio]methyl]-4-oxo-2-piperidine carboxylic acid] Virginiamycin S1. Grades: 95%. CAS No. 120138-50-3. Molecular formula: C53H67N9O10S. Mole weight: 1022.22.
Quinupristin-Dalfopristin complex
Quinupristin-dalfopristin complex is a 70:30 (w/w) complex of two semi-synthetic Streptomycin antibiotic. It is a highly effective antibiotic with activity against resistant strains. Synonyms: Synercid complex; Dalfopristin-Quinupristin complex; RP 59500; 4-[4-(dimethylamino)-N-methyl-L-phenylalanine]-5-[(2S)-5-[(1-azabicyclo[2.2.2]oct-3-ylthio)methyl]-4-oxo-2-piperidinecarboxylic acid]-virginiamycin S1 mixture with (3R, 4R, 5E, 10E, 12E, 14S, 26R, 26aS)-26-[[2-(diethylamino)ethyl]sulfonyl]-8, 9, 14, 15, 24, 25, 26, 26a-octahydro-14-hydroxy-4, 12-dimethyl-3-(1-methylethyl)-3H-21, 18-nitrilo-1H, 22H-pyrrolo[2, 1-c][1, 8, 4, 19]dioxadiazacyclotetracosine-1, 7, 16, 22(4H, 17H)-tetrone. Grades: >98% by HPLC. CAS No. 126602-89-9. Molecular formula: C53H67N9O10S.C34H50N4O9S. Mole weight: 1713.09.
R1128 A
R1128 A is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 A for partially purified rat uterine cytosol receptor was 11 x 10(-7) M. Synonyms: R1128A; R-1128A. CAS No. 135161-96-5. Molecular formula: C17H14O5. Mole weight: 298.29.
R1128 B
R1128 B is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 B for partially purified rat uterine cytosol receptor was 1.2 x 10(-7) M. Synonyms: R1128B; R-1128B. CAS No. 135161-97-6. Molecular formula: C18H16O5. Mole weight: 312.3.
R1128 C
R1128 C is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 C for partially purified rat uterine cytosol receptor was 2.6 x 10(-7) M. Synonyms: R1128C; R-1128C. CAS No. 135161-98-7. Molecular formula: C19H18O5. Mole weight: 326.3.
R176502
R176502 is a bafilolide metabolite with potent antiproliferative activity, which is produced by Micromonospora sp. JS1035. It inhibits proliferation of MCF-7, HT-29, K562/C1000 and Malme-3M cells with IC50 values of 1.29 ± 0.35, 0.61 ± 0.04, 9.29 ± 7.35, 7.96 ± 2.75 nmol/L. Synonyms: R 176502. Molecular formula: C47H67NO13. Mole weight: 854.