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Romurtide
Romurtide (Muroctasin) is a non-specific immune stimulant. Synonyms: MDP-Lys (L18); muroctasin. CAS No. 78113-36-7. Molecular formula: C43H78N6O13. Mole weight: 887.11.
Roquefortine C
A potent tremorgenic mycotoxin originally isolated from penicillium roqueforti. It is a penicillium commercially used to ripen blue-veined cheese. Synonyms: Roquefortine; NSC 292134; (3E,5aS,10bR,11aS)-10b-(1,1-Dimethyl-2-propen-1-yl)-6,10b,11,11a-tetrahydro-3-(1H-imidazol-5-ylmethylene)-2H-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4(3H,5aH)-dione; (-)-Roquefortine C; Roquefortin. Grades: >99% by HPLC. CAS No. 58735-64-1. Molecular formula: C22H23N5O2. Mole weight: 389.45.
Roquefortine E
An analogue of roquefortine C, containing an additional isoprenyl unit on the imidazole similar to phenylhistin. Roquefortine E is an antimitotic agent. It is a selective, albeit weakly active, antitumour agent. Grades: >95% by HPLC. CAS No. 871982-52-4. Molecular formula: C27H31N5O2. Mole weight: 457.57.
Roridin A
It has antifungal effect, and it can inhibit 50% of mast cell tumor P815 cells at 0.001 μg/mL in vitro. Synonyms: Roridine A; Roridan A; NSC 200737; Antibiotic 379X; Verrucarin A, 7'-deoxo-7'-(1-hydroxyethyl)-. Grades: ≥98%. CAS No. 14729-29-4. Molecular formula: C29H40O9. Mole weight: 532.62.
Roridin C
Roridin C is a fungal sesquiterpene derived from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: Trichodermol; BRN 1287601; 12,13-Epoxytrichothec-9-en-4-beta-ol; (2S,2'R,4'R,5'S,5a'R,9a'R)-5',5a',8'-trimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-4'-ol. Grades: >98%. CAS No. 2198-93-8. Molecular formula: C15H22O3. Mole weight: 250.33.
Roridin D
Roridin D is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: Roridin-D; 7'-Deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)verrucarin A; Verrucarin A, 7'-deoxo-2'-deoxy-2',3'-epoxy-7'-(1-hydroxyethyl)-; NSC-374338. CAS No. 14682-29-2. Molecular formula: C29H38O9. Mole weight: 530.61.
Roridin E
Roridin E is a macrocyclic trichothecene mycotoxin that has been found in M. verrucaria. It exhibits anticancer activity against various cancer cell lines. Synonyms: Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-((1R)-1-hydroxyethyl)-, (2'E,7'R)-. Grades: ≥95% by HPLC. CAS No. 16891-85-3. Molecular formula: C29H38O8. Mole weight: 514.61.
Roridine H
Roridin E is originally isolated from Myrothecium roridum S-1135 (NRRL 3005). Synonyms: CL-72-VB-s; CL-72-VB-2; NSC 274540; Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7',5'-(ethylideneoxy)-. CAS No. 29953-50-2. Molecular formula: C29H36O8. Mole weight: 512.59.
Roridin J
Roridin J is originally isolated from Myrothecium roridum S-1135 (NRRL 3005) and it has anti-leukemia effect in mice. Synonyms: NSC-319082. CAS No. 74072-83-6. Molecular formula: C29H36O9. Mole weight: 528.59.
Roridin L2
Roridin L2 is originally isolated from M. roridum var. and it has antibacterial and antitumor effects. Synonyms: (2S,2'R,4'R,5'S,5a'R,9a'R)-5a'-(hydroxymethyl)-5',8'-dimethyl-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-4'-yl (2Z,4E)-7-hydroxy-6-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethoxy)octa-2,4-dienoate. Grades: >70%. CAS No. 85124-22-7. Molecular formula: C29H38O9. Mole weight: 530.61.
Roselipin 1A
Roselipin 1A is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L. CAS No. 232258-17-2. Molecular formula: C40H72O14. Mole weight: 776.99.
Roselipin 1B
Roselipin 1B is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L. CAS No. 232258-18-3. Molecular formula: C40H72O14. Mole weight: 776.99.
Roselipin 2A
Roselipin 2A is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L. Synonyms: Roselipin-2A. CAS No. 232258-26-3. Molecular formula: C42H74O15. Mole weight: 819.03.
Roselipin 2B
Roselipin 2B is produced by the strain of Gliocladium roseum KF-1040. It inhibited the DGAT of rat hepatic microcosm with IC50 of 15~22 μmol/L. Synonyms: Roselipin-2B. CAS No. 232258-27-4. Molecular formula: C42H74O15. Mole weight: 819.03.
Roseoferin A1
Roseoferin A1 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity. Molecular formula: C59H108N10O12. Mole weight: 1149.54.
Roseoferin C2
Roseoferin C2 is an aminolipopeptide antibiotic produced by Mycogone rosea DSM 12973. It has strong anti-Gram-positive bacteria, Mycobacterium, Candida albicans, yeast and Penicillium activity, with MIC of 0.36-6.25 μg/mL. Cytotoxicity. Molecular formula: C60H110N10O12. Mole weight: 1163.57.
Roseoflavin
An antibacterial pigment isolated from streptomyces davawensis; an anti-metabolite of riboflavin; mimic riboflavin in flavin biosynthesis; an important regulator of bacterial gene expression by binding to untranslated regions of RNA, so-called ribo-switching sites. Synonyms: 8-demethyl-8-(dimethylamino)riboflavin; 1-Deoxy-1-[8-(Dimethylamino)-7-Methyl-2,4-Dioxo-3,4-Dihydrobenzo[g]pteridin-10(2h)-Yl]-D-Ribitol; Roseoflavine; 8-Dimethylaminoriboflavin. Grades: >98% by HPLC. CAS No. 51093-55-1. Molecular formula: C18H23N5O6. Mole weight: 405.40.
Roseorubicin A
It is produced by the strain of Actinomyces roseoviolaceus A529. It has anti-gram-positive bacteria and mycobacterium effect, and Roseorubicin A has stronger antibacterial effect than B. It also inhibits leukaemia L1210 with IC50 of 0.04 μg/mL. Synonyms: BRN 1419073. CAS No. 70559-00-1. Molecular formula: C54H78N2O18. Mole weight: 1043.20.
Roseorubicin B
It is produced by the strain of Actinomyces roseoviolaceus A529. It has anti-gram-positive bacteria and mycobacterium effect, and Roseorubicin A has stronger antibacterial effect than B. It also inhibits leukaemia L1210 with IC50 of 0.06 μg/mL. Synonyms: BRN 1417572; 2-ethyl-2,5,7,12-tetrahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 2, 3, 6-trideoxy-3- (dimethylamino) -4-O-[2, 3, 6-trideoxy-3- (dimethylamino) hexopyranosyl]hexopyranoside. CAS No. 70559-01-2. Molecular formula: C36H48N2O11. Mole weight: 684.77.
ROSEOTOXIN
Roseotoxin is a cyclic depeptide that can improve allergic contact dermatitis through a unique anti-inflammatory mechanism. Synonyms: CYCLO[2-HYDROXY-4-METHYL-PENTANOIC ACID-3-METHYL-PROLIN-ISOLEUCINE-N-METHYL-VALINE-N-METHYL-ALANINE-BETA-ALANINE]; ROSEOTOXIN; roseotoxin B; Cyclo[2-Hydroxy-4-methyl-pentanoic acid-3-methyl-prolin-Isoleucine-N-methyl-Valine-N-methyl-Alanine-beta-Alanine]; Cy. CAS No. 55466-29-0. Molecular formula: C30H49N5O7. Mole weight: 591.74.
Rotigaptide
Rotigaptide is a peptide drug used to treat arrhythmia. Synonyms: CHEMBL450656; GAP-486; ZP-123; ZP 123; ZP123 peptide; ZP-123 (ZEALAND); acetyl-tyrosyl-prolyl-hydroxyprolyl-glycyl-alanyl-glycinamide. Grades: >98%. CAS No. 355151-12-1. Molecular formula: C28H39N7O9. Mole weight: 617.65.
Roxithromycin Impurity C
An impurity found in the macrolide antibiotic, Clarithromycin. It exhibits antibacterial properties. Synonyms: 9-Erythromycin 9-Oxime; 9-Erythromycin A Oxime; Erythromycin Oxime; Roxithromycin Impurity C; Clarithromycin EP Impurity J. Grades: >95%. CAS No. 13127-18-9. Molecular formula: C37H68N2O13. Mole weight: 748.94.
Roxithromycin Impurity F
A metabolite of the macrolide antibiotic, Roxithromycin. Synonyms: (9E)-9-[O-[(2-Methoxyethoxy)methyl]oxime]-N-demethyl Erythromycin; (E)-N-Demethylroxithromycin; N-Demethylroxithromycin; RU 44981; Roxithromycin Impurity 6; Roxithromycin EP Impurity F. Grades: >95%. CAS No. 118267-18-8. Molecular formula: C40H74N2O15. Mole weight: 823.02.
RP-1551-1
RP-1551-1 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor potentially via reacting with amino groups on the alpha-receptor extracellular domain. Molecular formula: C25H29ClO6. Mole weight: 460.9.
RP-1551-2
RP-1551-2 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C24H31ClO5. Mole weight: 435.
RP-1551-3
RP-1551-3 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H27ClO5. Mole weight: 442.9.
RP-1551-4
RP-1551-4 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H29ClO6. Mole weight: 460.9.
RP-1551-5
RP-1551-5 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H33ClO5. Mole weight: 449.
RP-1551-6
RP-1551-6 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C25H29ClO6. Mole weight: 460.9.
RP-1551-7
RP-1551-7 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C19H23ClO4. Mole weight: 350.8.
RP-1551-8
RP-1551-8 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C26H31ClO6. Mole weight: 474.97.
RP-1551-9
RP-1551-9 is a compound in the class of azaphilone produced by Penicillium sp. SPC-21609. It inhibits the binding of PDGF AA to the extracellular domain of PDGF alpha-receptor. Molecular formula: C19H25ClO4. Mole weight: 352.85.
RP-1776
RP-1776 is a cyclic peptide isolated from the culture broth of Streptomyces sp. KY11784. It selectively inhibits the binding of PDGF BB to the extracellular domain of the PDGF beta-receptor with an IC50 value of 11 ± 6 μmol/L. Synonyms: RP 1776; RP1776. Molecular formula: C75H94N12O20. Mole weight: 1483.61.
RP-66453
RP-66453 is a secondary peptide metabolite produced by Streptomyces sp. A 9738. It can selectively bind to neurotensin receptor. Synonyms: RP 66453; RP66453. Molecular formula: C33H36N4O8. Mole weight: 616.7.
RP-71955
RP-71955 is a tricyclic 21 amino acid peptide produced by Streptomyces sp. SP9400. It is active against HIV-1. Synonyms: RP 71955; RP71955. CAS No. 152835-17-1. Molecular formula: C97H131N23O26S4. Mole weight: 2163.5.
RPI856 A
RPI856 A is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856A; RPI-856 A. Molecular formula: C43H61N7O13. Mole weight: 884.
RPI856 B
RPI856 B is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856B; RPI-856 B. Molecular formula: C43H61N7O13. Mole weight: 884.
RPI856 C
RPI856 C is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856Cl RPI-856 C. Molecular formula: C39H56N6O10. Mole weight: 768.9.
RPI856 D
RPI856 D is a retrovirus protease inhibitor produced by Streptomyces sp. AL-322. It strongly inhibits in vitro HIV-1 protease and HTLV-I protease both derived from recombinant Escherichia coli. Synonyms: RPI856D; RPI-856 D. Molecular formula: C39H56N6O10. Mole weight: 768.9.
RPR113228
RPR113228 is a farnesyl-protein transferase inhibitor produced by Chrysosporium lobatum. It has no inhibitory effect on squalene synthase. Synonyms: RPR-113228; RPR113228. Molecular formula: C30H49O9P. Mole weight: 584.7.
RS-22A
RS-22A is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 A. Molecular formula: C54H91N3O17. Mole weight: 1054.3.
RS-22B
RS-22B is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 B. Molecular formula: C55H93N3O17. Mole weight: 1068.3.
RS-22C
RS-22C is a macrolide antibiotic produced by Streptomyces violaceusniger. It is active against gram-positive, gram-negative bacteria, yeast and filamentous fungi. Synonyms: RS-22 C. Molecular formula: C56H95N3O17. Mole weight: 1082.4.
It is originally isolated from Actinomadura soseoviolacea var. biwakoensis. Rubeomycin A has the effect of anti-gram-positive bacteria, but not anti-gram-negative bacteria and fungi. It has also been shown to inhibit Yoshida sarcoma cells and leukemia P388 cells. Molecular formula: C33H41NO13. Mole weight: 659.68.
Rubeomycin A1
It is originally isolated from Actinomadura soseoviolacea var. biwakoensis. Rubeomycin A has the effect of anti-gram-positive bacteria, but not anti-gram-negative bacteria and fungi. The inhibition of A1 of Yoshida sarcoma cells was 10 times higher than that of other components. Molecular formula: C33H41NO13. Mole weight: 659.68.
Rubiginone D2
Rubiginone D2 is an antibiotic originally isolated from Streptomyces sp. Go N1/5. It has the activity of inhibiting tumor cells. CAS No. 274913-71-2. Molecular formula: C20H16O6. Mole weight: 352.34.
Rubradirin B
Rubradirin B is produced by the strain of Str. achromogenes var. rubradiris. It has the effect of anti-gram-positive bacteria. Grades: >98%. CAS No. 68833-11-4. Molecular formula: C40H33N3O15. Mole weight: 795.70.
(-)-Rugulosin
It is the less common optical isomer of the mycotoxin, (+)-rugulosin. It is first isolated from myrothecium verrucaria. It is a mycotoxin with antiviral activity. Synonyms: Radicalisin; (5aR, 6S, 13aR, 14S, 17R, 18S, 19S, 20R)-1, 8, 9, 16, 17, 20-hexahydroxy-3, 11-dimethyl-14-hydro-5H, 6H-6, 13a, 5a, 14-(epibutane[1, 2, 3, 4]tetrayl)cycloocta[1, 2-b:5, 6-b']dinaphthalene-5, 7, 13, 15-tetraone; (1S,1'S,2R,2'R,3S,3'S,9aR,9'aR)-Rugulosin; [5aR-(5aR*, 6S*, 13aR*, 14S*, 17R*, 18S*, 19S*, 20R*)]-1, 7, 9, 15, 17, 20-hexahydroxy-3, 11-dimethyl-5H, 6H-6, 13a, 5a, 14-[1, 2, 3, 4]butanetetraylcycloocta[1, 2-b:5, 6-b']dinaphthalene-5, 8, 13, 16(14H)-tetrone. Grades: >98% by HPLC. CAS No. 21884-45-7. Molecular formula: C30H22O10. Mole weight: 542.49.
Rugulosin ((+) form)
An intense yellow pigment produced by some species of penicillium, aspergillus and the fungal symbiotants of some lichens; shows antibacterial and insecticidal activity; an inhibitor of RNA Polymerase and Rnase. Synonyms: (+)-Rugulosin; Radicalisin; NSC 160880; 5H,13a,5a,14-[1,2,3,4]Butanetetraylcycloocta[1,2-b:5,6-b']dinaphthalene-5,8,13,16(14H)-tetrone, 1,7,9,15,17,20-hexahydroxy-3,11-dimethyl-. Grades: >98% by HPLC. CAS No. 23537-16-8. Molecular formula: C30H22O10. Mole weight: 542.49.
Rugulotrosin A
It is a symmetric dimer antibiotic isolated from an uncharacterised species of penicillium. It displays significant antibacterial activity against a wide range of gram-positive bacteria. Synonyms: (4R,4'R,4aR,4'AR,7R)-Rel-2,2',3,3',4,4',9,9'-Octahydro-1,1',4,4',8,8'-Hexahydroxy-6,6'-Dimethyl-9,9'-Dioxo-[7,7'-Bi-4aH-Xanthene]-4a,4'A-Dicarboxylic Acid Dimethyl Ester. Grades: >98% by HPLC. CAS No. 685135-81-3. Molecular formula: C32H30O14. Mole weight: 638.57.
(S)-10,11-Dehydrocurvularin
It is a natural mycotoxin that has cytotoxic activity against select cancer cell lines. It has been shown to activate the heat shock response, block TGF-β signaling, and scavenge superoxide anions. Synonyms: alpha,beta-Dehydrocurvularin; Trans-Dehydrocurvularin; (S)-10,11-dehydrocurvularin; (10E,15S)-10,11-Dehydrocurvularin; (4S,8E)-4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione; (4S,8E)-4beta-Methyl-11,13-dihydroxy-1,4,5,6,7,10-hexahydro-2H-3-benzoxacyclododecin-2,10-dione; α,β-dehydro Curvularin. Grades: ≥98%. CAS No. 21178-57-4. Molecular formula: C16H18O5. Mole weight: 290.31.
S14-95
S14-95 is an inhibitor of the JAK/STAT pathway isolated from Penicillium sp. 14-95. It inhibits the IFN-gamma mediated expression of the reporter gene with IC50 values of 2.5 to approximately 5 mg/ml. It inhibits the expression of the proinflammatory enzymes COX-2 and NOS II at 5 microg/ml (10.8 mM) in LPS/IFN-gamma stimulated J774 mouse macrophages. Molecular formula: C28H34O5. Mole weight: 450.57.
S-15183a
S-15183a is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. It also inhibited endogenous SPH kinase activity in intact platelets. Synonyms: S-15183 a. Molecular formula: C25H36O5. Mole weight: 416.5.
S-15183b
S-15183b is a sphingosine kinase inhibitor produced by Zopfiella inermis SANK 15183. It inhibited sphingosine kinase from rat liver with IC50 value of 2.5 μmol/L. Synonyms: S-15183 b. Molecular formula: C27H40O5. Mole weight: 444.6.
S-19159
S-19159 is a modulator of neurite outgrowth produced by the ascomycete Preussia aemulans. Synonyms: S 19159; S19159. Molecular formula: C30H44O5. Mole weight: 484.7.
It is produced by the strain of Streptomyces sp. It has the activity of resistant gram-positive and negative bacteria, especially the Aeromonas salmonecida. Synonyms: 2,3-Dicarboxyaziridine. CAS No. 57528-68-4. Molecular formula: C4H5NO4. Mole weight: 131.09.
(2S)-2-Amino-2-(1-methylcyclopropyl)acetic acid hydrochloride is an amino acid antibiotic produced by Micromonospora miyakonensis PA-4046. It has activity against Escherichia coli. Synonyms: Antibiotic PA 40461 hydrochloride; L-2-(1-Methylcyclopropyl)glycine hydrochloride; PA-4046-I hydrochloride; (S)-2-(1-methylcyclopropyl)glycine hydrochloride; (alphaS)-alpha-Amino-1-methylcyclopropaneacetic acid hydrochloride. Grades: 97.0%. CAS No. 1523541-83-4. Molecular formula: C6H11NO2.HCl. Mole weight: 165.62.