BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AEM1 | AEM1 is a Nrf2 inhibitor. It decreases the expression of NRF2 controlled genes, sensitizes A549 cells to various chemotherapeutic agents, and inhibits the growth of A549 cells in vitro and in vivo. Synonyms: N-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-amine. Grade: >98%. CAS No. 1030123-90-0. Molecular formula: C20H14FN3O2S. Mole weight: 379.41. |  |
| Aerothionin | Aerothionin is a dimeric spiroisoxazoline derived from marine sponges that demonstrates antimycobacterial activity. Synonyms: (+)-aerothionin. Grade: ≥97%. CAS No. 28714-26-3. Molecular formula: C24H26Br4N4O8. Mole weight: 818.1. | |
| Aeruginosin 865 | Aeruginosin 865 is isolated from terrestrial cyanobacterium Nostoc sp. Lukeová 30/93 with anti-inflammatory effect. It is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation of NF-kB to the nucleus. Grade: >98.0%. CAS No. 1611990-01-2. Molecular formula: C41H64N6O14. Mole weight: 864.98. | |
| AES-135 | AES-135 is a hydroxamic acid-based pan-HDAC inhibitor with IC50s ranging from 190-1100 nM for HDAC3, HDAC6, HDAC8 and HDAC11. It prolongs the survival in an orthotopic mouse model of pancreatic cancer. Synonyms: Benzamide, 4-[[[4-(1,1-dimethylethyl)phenyl]methyl][2-[[(4-fluorophenyl)sulfonyl][(2,3,4,5,6-pentafluorophenyl)methyl]amino]acetyl]amino]-N-hydroxy-; 4-({N-[(4-Fluorophenyl)sulfonyl]-N-(pentafluorobenzyl)glycyl}[4-(2-methyl-2-propanyl)benzyl]amino)-N-hydroxybenzamide. Grade: ≥98%. CAS No. 2361659-61-0. Molecular formula: C33H29F6N3O5S. Mole weight: 693.66. | |
| AES-350 | AES-350 is an effective and orally active HDAC6 inhibitor with IC50 and Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 shows higher HDAC isoform selectivity, higher MV4-11 cell cytotoxicity, improved treatment window and more effective absorption through cells and lipid membranes. Synonyms: Tert-Butylbenzamido Hydroxylbenzamide. Grade: 98%. CAS No. 847249-57-4. Molecular formula: C18H20N2O3. Mole weight: 312.4. | |
| Aescin polysulphate sodium salt | Aescin polysulphate sodium salt is a remarkable biomedical compound with anti-inflammatory and antithrombotic prowess acting as an exquisite derivative of Aescin. Molecular formula: C53H82O36S4. Mole weight: 1423.46. | |
| AEW-541 | AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NVP-AEW541 abrogates IGF-I-mediated survival and colony formation in soft agar at concentrations that are consistent with inhibition of IGF-IR autophosphorylation. NVP-AEW541 represents a class of selective, small molecule IGF-IR kinase inhibitors with proven in vivo antitumor activity and potential therapeutic application. Synonyms: NVP-AEW541; NVP-AEW 541; NVP-AEW-541; AEW-541; AEW 541; AEW541. Grade: 0.98. CAS No. 475489-16-8. Molecular formula: C27H29N5O. Mole weight: 439.563. | |
| AEZS-108 | AEZS-108, also known as AN-152 or zoptarelin doxorubicin, is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). Zoptarelin doxorubicin binds to GnRH-1Rs, which may be highly expressed on endometrial and ovarian tumor cell membrane surfaces, and is internalized. Once inside the cell, the doxorubicin moiety of this agent intercalates into DNA and inhibits the topoisomerase II activity, which may result in the inhibition of tumor cell DNA replication and tumor cell proliferation. Synonyms: AEZS 108; AEZS108; AN 152; AN-152; AN152; Zoptarelin doxorubicin; Zoptrex; Lys(6)-LHRH-doxorubicin. Grade: 98%. CAS No. 139570-93-7. Molecular formula: C91H117N19O26. Mole weight: 1893.01. | |
| AEZS-112 | AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase inhibition and is therefore a good candidate for in vivo studies in these tumors. Synonyms: ZEN012; ZEN 012; ZEN-012; AEZS 112; AEZS112. Grade: 98%. CAS No. 1214741-69-1. Molecular formula: C25H23N3O2. Mole weight: 397.47. | |
| AF3485 | AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 μM, respectively). Synonyms: CAY10686; N-[9-(2-hydroxyethyl)carbazol-3-yl]-2-(trifluoromethyl)benzamide. Grade: ≥95%. CAS No. 1195786-61-8. Molecular formula: C22H17F3N2O2. Mole weight: 398.4. | |
| AF 353 | AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. It is a highly potent inhibitor of α,β-meATP-evoked intracellular calcium flux in cell lines expressing recombinant rat and human P2X3 and human P2X2/3 channels. It also blocks human P2X2/3 channel function with marginally reduced potency (pIC50 = 7.3). It significantly reduces this parameter in both groups. It also reduces the inter-contractile interval in control but not in SCI rats. Synonyms: AF353; AF-353; 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-; Ro 4; 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyrimidinediamine. Grade: >98%. CAS No. 865305-30-2. Molecular formula: C14H17IN4O2. Mole weight: 400.21. | |
| AF38469 | AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor and shows no activity against the NTR1 receptor. Synonyms: AF 38469; AF-384694. CAS No. 1531634-31-7. Molecular formula: C15H11F3N2O3. Mole weight: 324.25. | |
| AF64394 | AF64394 is a potent and selective GPR3 inverse agonist. Synonyms: AF 64394; AF-64394; N-(4-chloro-2-isopropoxybenzyl)-5-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine. Grade: >98%. CAS No. 1637300-25-4. Molecular formula: C21H20ClN5O. Mole weight: 393.87. | |
| Afabicin | Afabicin is the prodrug of Debio1452 and an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Synonyms: Debio 1450; AFN-1720. CAS No. 1518800-35-5. Molecular formula: C23H24N3O7P. Mole weight: 485.43. | |
| Afacifenacin | Afacifenacin acts as a sodium/calcium exchanger inhibitor used in the prevention of reperfusion injury associated with restoration of coronary blood flow via surgery. Synonyms: (S)-(+)-3-[1-[3-(Trifluoromethoxy)benzyl]piperidin-4-yl]-4-phenyl-3,4-dihydro-1H-quinazolin-2-one. Grade: > 95%. CAS No. 877606-63-8. Molecular formula: C27H26F3N3O2. Mole weight: 481.52. | |
| Afatinib | Afatinib irreversibly inhibits EGFR/HER2 including EGFR, EGFR(L858R), EGFR(L858R/T790M) and HER2. It is 100-fold more active against Gefitinib-resistant L858R-T790M EGFR mutant. Uses: Antineoplastic agents. Synonyms: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-; (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; BIBW 2992; Gilotrif; Giotrif; Tovok; (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grade: >98%. CAS No. 850140-72-6. Molecular formula: C24H25ClFN5O3. Mole weight: 485.94. | |
| Afatinib impurity 11 | Afatinib impurity 11 is an impurity of Afatinib, which is an irreversible EGFR family inhibitor used to treat non-small cell lung cancer (NSCLC). Synonyms: 2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-; (S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)acrylamide; N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydro-3-furanyloxy]-6-quinazolinyl}acrylamide. Grade: ≥95%. CAS No. 1402086-20-7. Molecular formula: C21H18ClFN4O3. Mole weight: 428.84. | |
| Afatinib Impurity 2 | An analogue of Afatinib. Synonyms: 7-Quinazolinol, 4-[(3-chloro-4-fluorophenyl)?amino]?-6-nitro-. Grade: > 95%. CAS No. 1449430-45-8. Molecular formula: C14H8ClFN4O3. Mole weight: 334.7. | |
| Afatinib Impurity 2F3Cl-1 | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: 4-Quinazolinamine, N-(3-chloro-2-fluorophenyl)-7-fluoro-6-nitro-. Grade: ≥95%. CAS No. 936558-43-9. Molecular formula: C14H7ClF2N4O2. Mole weight: 336.68. | |
| Afatinib Impurity 5 | An analogue of Afatinib. Synonyms: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)?-7-methoxy-6-nitro-. Grade: > 95%. CAS No. 179552-74-0. Molecular formula: C15H10ClFN4O3. Mole weight: 348.72. | |
| Afatinib Impurity 52 | Afatinib Impurity 52 is an impurity of Afatinib, a drug used to treat non-small cell lung cancer (NSCLC). Synonyms: (S)-diethyl 2-(4-(3-chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-ylamino)-2-oxoethylphosphonate; Diethyl {[4-(3-Chloro-4-Fluoro-Phenylamino)-7-((S)-Tetrahydrofuran-3-Yloxy)-Quinazolin-6-Ylcarbamoyl]-Methyl}-Phosphonate. Grade: 95%. CAS No. 618061-76-0. Molecular formula: C24H27ClFN4O6P. Mole weight: 552.92. | |
| Afatinib Impurity A | An analogue of Afatinib. Synonyms: 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)?-6-nitro-7-[[(3R)?-tetrahydro-3-furanyl]?oxy]?-. Grade: > 95%. CAS No. 402855-07-6. Molecular formula: C18H14ClFN4O4. Mole weight: 404.79. | |
| Afatinib Impurity AFT-8 | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: Afatinib Impurity QJJ; N-[4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutenamide; Butanamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-3-hydroxy-. Grade: ≥95%. CAS No. 2323570-72-3. Molecular formula: C24H27ClFN5O4. Mole weight: 503.95. | |
| Afatinib Impurity B | An analogue of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: Afatinib-des(4-dimethylamino-2-en-1-oxo)butyl; N4-(3-Chloro-4-fluorophenyl)-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4,6-quinazolinediamine; (S)-N4-(3-Chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine. Grade: > 95%. CAS No. 314771-76-1. Molecular formula: C18H16ClFN4O2. Mole weight: 374.81. | |
| Afatinib Impurity C | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)?amino]?-7-[[(3R)?-tetrahydro-3-furanyl]?oxy]?-6-quinazolinyl]?-4-(dimethylamino)?-, (2E)?-. Grade: > 95%. CAS No. 945553-91-3. Molecular formula: C24H25ClFN5O3. Mole weight: 485.95. | |
| Afatinib Impurity CSEJXA | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide (Afatinib Impurity; (S)-N1-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)-N2,N2-DIMETHYLOXALAMIDE; Afatinib Impurity CSEJXA; CS-0164258; E82032; (S)-N1-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-N2,N2-dimethyloxalamide (Afatinib Impurity pound(c). Grade: ≥95%. CAS No. 2223677-66-3. Molecular formula: C22H21ClFN5O4. Mole weight: 473.88. | |
| Afatinib Impurity CSZ | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C22H20ClFN4O5. Mole weight: 474.87. | |
| Afatinib Impurity D | An analogue of Afatinib, a medication indicated for the treatment of non-small cell lung carcinoma (NSCLC). Synonyms: (2Z)-Afatinib; Z-Afatinib; (S,Z)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grade: > 95%. CAS No. 1680184-59-1. Molecular formula: C24H25ClFN5O3. Mole weight: 485.95. | |
| Afatinib Impurity ESS | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C30H34ClFN6O4. Mole weight: 597.09. | |
| Afatinib Impurity I | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: Bromo-Afatinib; (S,E)-4-bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide. Grade: ≥95%. CAS No. 1637254-93-3. Molecular formula: C22H19BrClFN4O3. Mole weight: 521.78. | |
| Afatinib Impurity J | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (2E)-N-[3,4-Dihydro-4-oxo-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; (S,E)-4-(DIMETHYLAMINO)-N-(4-HYDROXY-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)BUT-2-ENAMIDE; (S,e)-4-(dimethylamino)-N-(4-oxo-7-((tetrahydrofuran-3-yl)oxy)-3,4-dihydroquinazolin-6-yl)but-2-enamide; Afatinib Impurity J; SCHEMBL17352060; SCHEMBL17352063; GSUSIQVMAQBROU-PCAWENJQSA-N; CS-0164268; E82037; (S,E)-4-(Dimethylamino)-N-(4-hydroxy-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity). Grade: > 95%. CAS No. 1456696-14-2. Molecular formula: C18H22N4O4. Mole weight: 358.4. | |
| Afatinib Impurity JXH | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]formamide; Des(N,N-Dimethylprop-2-enyl-1-Amine) Afatinib. Grade: ≥95%. CAS No. 2223677-60-7. Molecular formula: C19H16ClFN4O3. Mole weight: 402.81. | |
| Afatinib Impurity N-Oxide | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S,E)-4-((4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide. Grade: ≥95%. CAS No. 2413212-11-8. Molecular formula: C24H25ClFN5O4. Mole weight: 501.94. | |
| Afatinib Impurity O | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S,E)-4-broMo-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enaMide; (E)-4-bromo-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide; Bromo-Afatinib; C22H19BrClFN4O3; AFATINIB IMPURITY O; SCHEMBL16398947; SCHEMBL16398952; IQJWAIKYBNTYPG-YUKKFKLSSA-N; CS-0164267; (2E)-4-Bromo-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-2-butenamide; (S,E)-4-Bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity). Grade: ≥95%. Molecular formula: C18H15FN4O4. Mole weight: 370.34. | |
| Afatinib Impurity Q | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C14H7ClF2N4O2. Mole weight: 336.68. | |
| Afatinib Impurity QA | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C18H16ClFN4O3. Mole weight: 390.80. | |
| Afatinib Impurity SCl | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S,E)-N-(4-((3,4-Dichlorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Grade: ≥95%. CAS No. 2223677-63-0. Molecular formula: C24H25Cl2N5O3. Mole weight: 502.39. | |
| Afatinib Impurity SM2A | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: 2-Butenamide, 4-(dimethylamino)-N,N-dimethyl-. Grade: ≥95%. CAS No. 1862246-17-0. Molecular formula: C8H16N2O. Mole weight: 156.23. | |
| Afatinib Impurity WZYGNH2 | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C18H16ClFN4O2. Mole weight: 370.80. | |
| Afatinib Impurity WZYGNO2 | An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Grade: ≥95%. Molecular formula: C18H14ClFN4O4. Mole weight: 404.78. | |
| AFB-Guanine-13C,15N2 | A labelled guanine adduct of Aflatoxin B1. Synonyms: (6aS,8R,9R,9aR)-8-(2-Amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3,6a,8,9,9a-hexahydro-9-hydroxy-4-methoxy-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione-13C,15N2. Molecular formula: C21[13C]H17N3[15N]2O8. Mole weight: 482.38. | |
| AFB-Guanine Acetic Acid Salt | Acetic acid of a guanine adduct of Aflatoxin B1. Synonyms: (6aS,8R,9R,9aR)-8-(2-Amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3,6a,8,9,9a-hexahydro-9-hydroxy-4-methoxy-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione Acetic Acid. Grade: 95%. Molecular formula: C24H21N5O10. Mole weight: 539.45. | |
| AF-DX 116 | AF-DX 116 has been found to be a selective mAChR M2 antagonist. Synonyms: Otenzepad; AF-DX 116; AF-DX-116; AF-DX116; 11-[[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one. Grade: ≥98% by HPLC. CAS No. 102394-31-0. Molecular formula: C24H31N5O2. Mole weight: 421.54. | |
| AF-DX 384 | AF-DX 384 has been found to be a mAChR M2/M4 selective antagonist. Uses: Parasympatholytics. Synonyms: N-[2-[2-[(Dipropylamino)methyl]-1-piperidinyl]ethyl]-5,6-dihydro-6-oxo-11H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide. Grade: ≥98% by HPLC. CAS No. 118290-26-9. Molecular formula: C27H38N6O2. Mole weight: 478.64. | |
| Afelimomab | Afelimomab is a mouse monoclonal antibody directed against TNFα. Afelimomab has been used in the research of sepsis treatment. Synonyms: MAK-195F; MAK 195F; MAK195F. Grade: 95%. CAS No. 156227-98-4. | |
| AFG206 | AFG206 is the novel first-generation "type II" FLT3 inhibitor. Synonyms: AFG-206; AFG 206. Grade: >98%. CAS No. 630122-37-1. Molecular formula: C20H19N3O2. Mole weight: 333.38. | |
| AFG210 | AFG210 is a novel first-generation "type II" FLT3 inhibitor. Synonyms: AFG 210; AFG-210; 1-(3-(trifluoromethyl)phenyl)-3-(4-(pyridin-4-yloxy)phenyl)urea. Grade: >98%. CAS No. 228400-22-4. Molecular formula: C19H14F3N3O2. Mole weight: 373.33. | |
| Aficamten | Aficamten is a next-generation cardiac myosin inhibitor with IC50 of 1.4 μM, for the treatment of symptomatic obstructive hypertrophic cardiomyopathy. Synonyms: CK 3773274; CK-3773274; CK3773274; CK-274. CAS No. 2364554-48-1. Molecular formula: C18H19N5O2. Mole weight: 337.38. | |
| Afimetoran | Afimetoran is an orally active toll-like receptor 7 and 8 (TLR7/8) dual antagonist that can be used to study inflammatory and autoimmune diseases. Synonyms: BMS-986256; 1-Piperidineacetamide, 4-[2-(7,8-dimethyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-(1-methylethyl)-1H-indol-5-yl]-; 2-(4-(2-(7,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-isopropyl-1H-indol-5-yl)piperidin-1-yl)acetamide. Grade: ≥98%. CAS No. 2171019-55-7. Molecular formula: C26H32N6O. Mole weight: 444.57. | |
| Afimoxifene | Afimoxifene (4-hydroxytamoxifen) is a selective estrogen receptor modulator which is the active metabolite of tamoxifen. Afimoxifene is a transdermal gel formulation and is being developed by Ascend Therapeutics, Inc. under the trademark TamoGel. Afimoxifene has completed a phase II clinical trial for the treatment of cyclical mastalgia. Uses: Estrogen antagonists. Synonyms: (E/Z)-4-Hydroxytamoxifen; 4-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol; TamoGel; Phenol, 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-. Grade: ≥95%. CAS No. 68392-35-8. Molecular formula: C26H29NO2. Mole weight: 387.51. | |
| Aflatoxin B1-13C-d3 | Aflatoxin B1 labelled standard. Synonyms: (6aR,9aS)-2,3,6a,9a-Tetrahydro-4-(methoxy)-1H,11H-cyclopenta[c]furo[3',2':4,5]furo[2,3-h][1]benzopyran-1,11-dione-13C,d3; (-)-Aflatoxin B1-13C,d3. Grade: > 95%. Molecular formula: C17H9O6D3. Mole weight: 316.29. | |
| Aflatoxin G1-[13C17] | Aflatoxin G1-[13C17] is a labelled Aflatoxin G1, a mycotoxin produced by Aspergillus flavus. Synonyms: Aflatoxin G1-13C17; Fully 13C-labelled Aflatoxin G1. Grade: 95%. CAS No. 1217444-07-9. Molecular formula: [13C]17H12O7. Mole weight: 345.15. | |
| Aflibercept | Aflibercept is a recombinant fusion protein and acts as a VEGF inhibitor. Aflibercept is used for the treatment of wet macular degeneration and metastatic colorectal cancer. Synonyms: Eylea. CAS No. 862111-32-8. Molecular formula: C4318H6788N1164O1304S32. Mole weight: 96898.57. | |
| AFN-1252 | AFN-1252 is an enoyl-(acyl-carrier protein) reductase fabl inhibitor, inhibited all clinical isolates of Staphylococcus aureus and Staphylococcus epidermidis at concentrations of ≤0.12 μg/ml. Uses: Antibacterial. Synonyms: AFN-1252; AFN 1252; AFN1252; AFN-12520000; API-1252; Debio-1452; AFN12520000; API1252; Debio1452. (E)-N-methyl-N-[(3-methyl-1-benzofuran-2-yl)methyl]-3-(7-oxo-6,8-dihydro-5H-1,8-naphthyridin-3-yl)prop-2-enamide. Grade: ≥95%. CAS No. 620175-39-5. Molecular formula: C22H21N3O3. Mole weight: 375.43. | |
| Afobazole | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346; Afobazol; Fabomotizole; CM 346; CM-346. Grade: >98%. CAS No. 173352-21-1. Molecular formula: C15H21N3O2S. Mole weight: 307.41. | |
| Afobazole hydrochloride | Fabomotizole (brand name Afobazole) is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF- and BDNF-release-promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Clinical trials have shown fabomotizole to be well tolerated and reasonably effective for the treatment of anxiety. Experiments of mice have showed antimutagenic and antiteratogenic properties. Synonyms: CM346 hydrochloride; Afobazol hydrochloride; Fabomotizole hydrochloride; CM 346 hydrochloride; CM-346 hydrochloride. Grade: >98%. CAS No. 173352-39-1. Molecular formula: C15H22ClN3O2S. Mole weight: 343.87. | |
| AFP 07 | AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor. Synonyms: (5Z)-5-[(3aR,4R,5R,6aS)-3,3-difluoro-5-hydroxy-4-[(E,3S,4S)-3-hydroxy-4-methylnon-1-en-6-ynyl]-4,5,6,6a-tetrahydro-3aH-cyclopenta[b]furan-2-ylidene]pentanoic acid. Grade: ≥98%. CAS No. 788799-13-3. Molecular formula: C22H30F2O5. Mole weight: 412.5. | |
| AFP-464 | AFP-464 is a synthetic lysyl prodrug of the amino-substituted flavone derivate aminoflavone with antiproliferative and antineoplastic activities. AFP464 is rapidly converted to aminoflavone in plasma. Aminoflavone activates the aryl hydrocarbon receptor (AhR) signaling pathway leading to an increase in cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1A2 (CYP1A2) expression and, to a lesser extent, an increase in cytochrome P450 1B1 (CYP1B1) expression. Synonyms: AFP464; AFP 464; Hexanamide, 2,6-diamino-N-(4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-1-benzopyran-2-yl)-2-fluorophenyl)-, (2S)-. CAS No. 468719-52-0. Molecular formula: C23H27F3N4O6S. Mole weight: 448.44. | |
| Aftobetin Hydrochloride | Aftobetin, also known as ANCA11 and NCE-11, is a novel amyloid-binding compound applied topically in the form of an ophthalmic ointment. Aftobetin may be of useful as an aid in the diagnosis Alzheimer's disease. Synonyms: Aftobetin Hydrochloride; NCE-11; Aftobetin Hydrochloride [USAN]; UNII-A1FCZ940WA; 1353222-83-9; A1FCZ940WA; 11-HCl; 2-Propenoic acid, 2-cyano-3-(6-(1-piperidinyl)-2-naphthalenyl)-, 2-(2-(2-methoxyethoxy)ethoxy)ethyl ester, hydrochloride (1:1), (2E)-; Aftobetin hydrochloride (USAN); 2-(2-(2-Methoxyethoxy)ethoxy)ethyl (2E)-2-cyano-3-(6-(piperidin-1-yl)naphthalen-2-yl)prop-2-enoate monohydrochloride; Aftobetin HCl; 2-[2-(2-Methoxyethoxy)ethoxy]ethyl (2E)-2-cyano-3-[6-(piperidin-1-yl)naphthalen-2-yl]prop-2-enoate monohydrochloride; aftobetin-hydrochloride; ANCA-11 HYDROCHLORIDE; CHEMBL2364602; DTXSID90159314; AKOS040750170; AFTOBETIN HYDROCHLORIDE [WHO-DD]; D10607; Q27273497. CAS No. 1353222-83-9. Molecular formula: C26H33ClN2O5. Mole weight: 489.009. | |
| Afuresertib | Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2110183 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. Synonyms: GSK-2110183; GSK 2110183; GSK2110183; GSK-2110183B; GSK 2110183B; GSK2110183B. Grade: 98%. CAS No. 1047644-62-1. Molecular formula: C18H17Cl2FN4OS. Mole weight: 427.32. | |
| Afuresertib HCl | Afuresertib HCl is a potent pan-AKT inhibitor. Synonyms: N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride; GSK2110183; GSK 2110183; GSK-2110183; GSK2110183B; GSK 2110183B; GSK2110183B; Afuresertib. Grade: >98%. CAS No. 1047645-82-8. Molecular formula: C18H18Cl3FN4OS. Mole weight: 463.78. | |
| AG-012917 | AG-012917 is a broad spectrum cyclin-dependent kinase inhibitor with potential anticancer activity. Synonyms: AG 012917; AG012917; (S)-4-((4-amino-5-(2,6-difluorobenzoyl)thiazol-2-yl)amino)-N-((1-methylpyrrolidin-2-yl)methyl)benzamide. Grade: >98%. CAS No. 486414-16-8. Molecular formula: C23H23F2N5O2S. Mole weight: 471.52. | |
| AG-012986 | AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 was seen (tumor growth inhibition,>83.1%) in 10 of 11 human xenograft tumor models. AG-012986 also showed dose-dependent retinoblastoma Ser(795) hypophosphorylation, cell cycle arrest, decreased Ki-67 tumor staining, and apoptosis in conjunction with antitumor activity. Synonyms: AG 012986; AG012986; Benzamide, 4-((4-amino-5-(2,6-difluorobenzoyl)-2-thiazolyl)amino)-N-((1R)-2-(dimethylamino)-1-methylethyl)-. Grade: >98%. CAS No. 486414-35-1. Molecular formula: C22H23F2N5O2S. Mole weight: 459.51. | |
| AG-024104 | AG-024104 is a broad spectrum cyclin-dependent kinase inhibitor with potential anticancer activity. Synonyms: AG 024104; AG024104. Grade: >98%. CAS No. 750575-23-6. Molecular formula: C24H28F2N6O4S2. Mole weight: 566.64. | |
| AG-024322 | AG-24322 is a second generation CDK inhibitor. AG-024322 is a potent inhibitor of CDK1, CDK2, and CDK4 that produces cell-cycle arrest and antitumor activity in preclinical models. Synonyms: AG-24322; AG 24322; AG24322. Grade: 98%. CAS No. 837364-57-5. Molecular formula: C23H20F2N6. Mole weight: 418.44. | |
| AG-041R | AG-041R is a potent gastrin/CCK2 receptor antagonist that exhibits selective binding for CCK2 compared to CCK1. Synonyms: 1H-Indole-3-acetamide, 1-(2,2-diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-, (+)-; (+)-1-(2,2-Diethoxyethyl)-2,3-dihydro-N-(4-methylphenyl)-3-[[[(4-methylphenyl)amino]carbonyl]amino]-2-oxo-1H-indole-3-acetamide; (+)-AG 041R; AG 041R; (R)-2-(1-(2,2-diethoxyethyl)-2-oxo-3-(3-(p-tolyl)ureido)indolin-3-yl)-N-(p-tolyl)acetamide. Grade: ≥98%. CAS No. 159883-95-1. Molecular formula: C31H36N4O5. Mole weight: 544.64. | |
| AG 045572 | AG 045572, a nonpeptidic GnRH antagonist, could probably be used in the treatment for sex hormone-dependent diseases and infertility. Synonyms: AG 045572; AG045572; AG-045572; 5-[5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl-methyl]-N-(2,4,6-trimethoxyphenyl)-2-furancarboxamide. Grade: ≥97% by HPLC. CAS No. 263847-55-8. Molecular formula: C30H37NO5. Mole weight: 491.62. | |
| AG-09/1 | AG-09/1. Synonyms: 2-[(6-methoxy-1H-benzimidazol-2-yl)thio]-N-(4-nitrophenyl)-acetamide. CAS No. 356776-32-4. Molecular formula: C16H14N4O4S. Mole weight: 358.37. | |
| AG-1024 | AG-1024 is also called Tyrphostin, is a selective inhibitor of IGF-1R. AG-1024 was used to evaluate effects on proliferation, radiosensitivity, and radiation-induced cell apoptosis in a human breast cancer cell line MCF-7. Exposure to Tyrphostin AG 1024 inhibited proliferation and induced apoptosis in a time-dependent manner, and the degree of growth inhibition for IC20 plus irradiation (4 Gy) was up to 50% compared to the control. Synonyms: AG1024; AG-1024; AG 1024. Tyrphostin. Grade: >98%. CAS No. 65678-07-1. Molecular formula: C21H27N7O. Mole weight: 393.23. | |
| AG 126 | Tyrphostins are protein tyrosine kinase inhibitors developed to inhibit cell growth through blocking the activity of certain GFRK (growth factor receptor kinases). AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also inhibits the production of TNF-α (tumor necrosis factor-α), attenuating signaling through NF-κB, the induced expression of COX-2 and iNOS, and the inflammatory response in animal models. AG 126 is a poor inhibitor of epidermal GFRK with IC50 of 450 μM and platelet-derived GFRK with IC50 > 100 μM. AG 126 may represent a new approach for the therapy of inflammation. Uses: Anti- inflammation. Synonyms: AG126; AG-126; Tyrphostin AG 126; UNII-7YA4AMD1JC; Tyrphostin A 10; alpha-Cyano-(3-hydroxy-4-nitro)cinnamonitrile. Grade: 95%. CAS No. 118409-62-4. Molecular formula: C10H5N3O3. Mole weight: 215.16. | |
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