BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| AM3102 | AM-3102 is an Oleoyl ethanolamide (OEA) analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency. The biological effects of OEA are terminated by N-acylethanolamine-hydrolyzing acid amidase and fatty-acid amide hydrolase. AM3102 demonstrates weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 33 and 26 μM, respectively. Synonyms: KDS-5104; AM-3102; AM 3102; Methyl oleoylethanolamide. Grade: ≥98%. CAS No. 213182-22-0. Molecular formula: C21H41NO2. Mole weight: 339.6. |  |
| AM-36 | AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates with an IC50 of 0.28 microM. As a unique neuroprotective agent with anti-oxidant activity, in neuronal cell cultures, AM-36 inhibited toxicity induced by N-methyl-D-aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis. Synonyms: 2,6-ditert-butyl-4-[[4-[2-(4-chlorophenyl)-2-hydroxyethyl]piperazin-1-yl]methyl]phenol; AM-36; AM 36; AM36; UNII-08OBY024NY; SCHEMBL12311270; CNSB 002; CNSB-002; CNSB002. Grade: >98%. CAS No. 199467-52-2. Molecular formula: C27H39ClN2O2. Mole weight: 459.06. | |
| AM 36 dihydrochloride | AM-36 is a potent blocker of batrachotoxinin (BTX)-sensitive Na+ channel binding in rat brain homogenates. As a unique neuroprotective agent with anti-oxidant activity, in neuronal cell cultures, AM-36 inhibited toxicity induced by N-methyl-D-aspartate (NMDA) and the sodium channel opener veratridine and, in addition, inhibited veratridine-induced apoptosis. Synonyms: CNSB002; 2,6-Di-tert-butyl-4-{4-[2-(4-chloro-phenyl)-2-hydroxy-ethyl]-piperazin-1-ylmethyl}-phenol dihydrochloride. Grade: 98%. CAS No. 1246094-77-8. Molecular formula: C27H39ClN2O2.2HCl. Mole weight: 531.99. | |
| AM404 | AM-404 is a selective inhibitor of the carrier-mediated transport of anandamide without affecting anandamide hydrolysis. AEM is also an analog of arachidonyl ethanolamide (AEA) which potentiates the activity of endogenous AEA by blocking its reuptake into presynaptic neurons. AM404 inhibits endocannabinoid cellular uptake, binds weakly to CB1 and CB2 cannabinoid receptors, and is formed by fatty acid amide hydrolase (FAAH) in vivo. Synonyms: 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (5Z,8Z,11Z,14Z)-; (5Z,8Z,11Z,14Z)-N-(4-Hydroxyphenyl)-5,8,11,14-eicosatetraenamide; 5,8,11,14-Eicosatetraenamide, N-(4-hydroxyphenyl)-, (all-Z)-; AM 404; AM404. Grade: ≥98%. CAS No. 183718-77-6. Molecular formula: C26H37NO2. Mole weight: 395.58. | |
| AM 4113 | AM4113 has been found to be a CB1 antagonist and could be used in studies of some neuronal dendritic abnormalities diseases. Synonyms: AM 4113; AM-4113; AM4113; 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide. Grade: ≥98% by HPLC. CAS No. 614726-85-1. Molecular formula: C17H12Cl3N3O. Mole weight: 380.66. | |
| AM4668 | AM4668 is a potent and selective G-protein coupled receptor 40(GPR40) agonist with EC50 value of 3.6 nM in an IP3 assay in GPR40 transfected A9 cells. It is more potent than AMG 837 and possesses excellent pharmacokinetic properties across species. It could reduce the plasma glucose levels in an OGTT study in human GPR40 knock-in mice. It inhibits insulin secretion from isolated pancreatic islets. Uses: Am4668 could reduce the plasma glucose levels in an ogtt study. it inhibits insulin secretion from isolated pancreatic islets. Synonyms: AM-4668; AM 4668; AM4668 ; (S)-3-(isoxazol-3-yl)-3-(4-((4-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-5-yl)methoxy)phenyl)propanoic acid; (βS)-β-[4-[[4-Methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]phenyl)-3-isoxazolepropanoic acid. Grade: >98 %. CAS No. 1011531-27-3. Molecular formula: C24H19F3N2O4S. Mole weight: 488.48. | |
| AM580 | AM580 is a selective RARα agonist. It was shown to induce differentiation of human induced pluripotent stem cells into intermediate mesoderm. Synonyms: AM-580; 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalene-2-carbonyl)amino]benzoic acid. Grade: >98%. CAS No. 102121-60-8. Molecular formula: C22H25NO3. Mole weight: 351.44. | |
| AM-643 | AM-643 is an active molecular. In the Biological Tests, it can inhibit FLAP in human whole blood assessed as inhibition of calcium ionophore A23187-induced LTB4 production preincubated for 5 hrs by ELISA and the activity value is 0.081μM. It can also Inhibit COX1-mediated TXB2 production in human whole blood after 30 mins by competitive enzyme immunoassay and the activity value is 25μM. Synonyms: AM-643 Free Acid; AM643 Free Acid; UNII-55668SZQ3E; 3-(3-(tert-butylthio)-1-(4-(5-methoxypyrimidin-2-yl)benzyl)-5-((5-methylpyridin-2-yl)methoxy)-1H-indol-2-yl)-2,2-dimethylpropanoic acid. Grade: 98%. CAS No. 1233114-22-1. Molecular formula: C36H40N4O4S. Mole weight: 642.79. | |
| AM 6545 | AM 6545 has been found to be a CB1 antagonist and could probably be used as an appetite suppressant. Synonyms: AM 6545; AM6545; AM-6545; 5-[4-(4-Cyano-1-butyn-1-yl)phenyl]-1-(2,4-dichlorophenyl)-N-(1,1-dioxido-4-thiomorpholinyl)-4-methyl-1H-pyrazole-3-carboxamide. Grade: ≥98% by HPLC. CAS No. 1245626-05-4. Molecular formula: C26H23Cl2N5O3S. Mole weight: 556.46. | |
| AM679 | AM679 is a drug which acts as a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP). This protein is involved in the production of cysteinyl leukotrienes which are involved in inflammation, and AM679 has anti-inflammatory effects in animal studies. AM679 also showed potent inhibition of leukotrienes in human blood and in a rodent bronchoalvelolar lavage (BAL) challenge model. Research showed AM679 reduces inflammation in the respiratory syncytial virus-infected mouse eye. Synonyms: AM-679; AM 679; AM679; UNII-65KJ8P7M9D; CHEMBL595092; SCHEMBL503239; 65KJ8P7M9D. Grade: >98%. CAS No. 1206880-66-1. Molecular formula: C40H44N4O5S. Mole weight: 692.87. | |
| AM-8508 | AM-8508 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-8508 exhibits good cellular potency (in vitro pAKT IC50 = 4.6 nM ) and excellent HWB potency (HWB (pAKT) IC50 = 2.7 nM). AM-8508 inhibits KLH-specific antibodies in animal models and it may become a drug candidate for the treatment of human inflammatory diseases. Uses: Inflammatory diseases. Synonyms: AM-8508; AM 8508; AM8508. (S)-4-amino-6-((1-(6-fluoro-1-(pyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grade: 98%. CAS No. 1338483-67-2. Molecular formula: C19H15FN8. Mole weight: 374.14. | |
| AM 92016 | AM92016 is a specific blocker of the time dependent delayed rectifier potassium current and may be useful in antiarrhythmic studies. Synonyms: Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, benzoate (1:1); Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, monobenzoate (salt); 1-(4-Methanesulfonamidophenoxy)-3-(N-methyl-3,4-dichlorophenylethylamino)-2-propanol, benzoic acid salt; AM-92016; AM92016; AM 92016 benzoate salt. Grade: ≥95%. CAS No. 178894-81-0. Molecular formula: C19H24Cl2N2O4S.C7H6O2. Mole weight: 569.50. | |
| AM 92016 hydrochloride | The hydrochloride salt form of AM 92016, which has been found to be a specific blocker of the time dependent delayed rectifier potassium current and probably be useful in antiarrhythmic studies. Synonyms: Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, hydrochloride (1:1); Methanesulfonamide, N-[4-[3-[[2-(3,4-dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]-, monohydrochloride; 1-(4-Methanesulfonamidophenoxy)-3-(n-methyl-3,4-dichlorophenylethylamino)-2-propanol hydrochloride. Grade: ≥98% by HPLC. CAS No. 133229-11-5. Molecular formula: C19H24Cl2N2O4S.HCl. Mole weight: 483.84. | |
| AM9405 | AM9405, a peripherally active cannabinoid type 1 (CB1) and serotonin type 3 receptor agonist, inhibits twitch contraction of ileum and colon with IC50s of 45.71 and 0.076 nM, respectively. Synonyms: 2-[2,6-Dihydroxy-4-(2-methyl-2-octanyl)phenyl]-1,3-dimethyl-1H-benzimidazol-3-ium bromide; 1H-Benzimidazolium, 2-[4-(1,1-dimethylheptyl)-2,6-dihydroxyphenyl]-1,3-dimethyl-, bromide (1:1). Grade: ≥95%. Molecular formula: C24H33BrN2O2. Mole weight: 461.44. | |
| AM-9514 | AM-9514 is a glucokinase (GK) activator. It shows a favorable combination of in vitro potency, enzyme kinetic properties, acceptable pharmacokinetic profiles in preclinical species, and robust efficacy in a rodent PD model. Glucokinase is very important in regulating glucose homeostasis. AM-9514 may become a drug candidate for the treatment of type 2 diabetes. Uses: Type 2 diabetes. Synonyms: AM-9514; AM9514; AM 9514; 1-(3-((1-ethyl-1H-pyrazol-5-yl)oxy)-5-(((1r,3s)-3-hydroxy-3-methylcyclobutyl)methyl)pyridin-2-yl)-3-methylurea. Grade: 98%. CAS No. 1442677-18-0. Molecular formula: C18H25N5O3. Mole weight: 359.43. | |
| AM-9635 | AM-9635 is a selective Phosphatidylinositol-3-kinase delta (PI3Kδ) inhibitor. AM-9635 exhibits good cellular potency (in vitro pAKT IC50 = 4.2 nM ). AM-9635 can inhibit KLH-specific IgG and IgM in a dosedependent manner and it is well tolerated at all doses. AM-96352 shows significantly reduced IgG and IgM specific antibodies. Synonyms: AM-9635; AM 9635; AM9635. (S)-4-amino-6-((1-(6-fluoro-1-(5-fluoropyridin-3-yl)-1H-benzo[d]imidazol-2-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grade: 98%. CAS No. 1338483-10-5. Molecular formula: C19H14F2N8. Mole weight: 392.36. | |
| AM 966 | AM966, a LPA1 receptor antagonist, has been found to restrain lung fibrosis in mouse model. IC50: 17 nM. Uses: Am966 is a lpa1 receptor antagonist that has been found to restrain lung fibrosis in mouse model. Synonyms: AM-966; AM 966; AM966; 2-[4-[4-[4-[[(1R)-1-(2-chlorophenyl)ethoxy]carbonylamino]-3-methyl-1,2-oxazol-5-yl]phenyl]phenyl]aceticacid; AM966; AM-966; UNII-CEO54NH393; 1228690-19-4; (R)-2-(4'-(4-(((1-(2-Chlorophenyl)ethoxy)carbonyl)amino)-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)acet. Grade: 95%. CAS No. 1228690-19-4. Molecular formula: C27H23ClN2O5. Mole weight: 490.93. | |
| a-Maltotetraosyl-a,a-trehalose | a-Maltotetraosyl-a,a-trehalose is an intricate and cutting-edge compound breakthrough, holding immense potential in the realm of studying an array of diseases such as neurodegenerative disorders and metabolic anomalies. CAS No. 171609-69-1. Molecular formula: C36H62O31. Mole weight: 990.86. | |
| Amantadine | Amantadine can be used as an antiviral and an antiparkinsonian drug. It is a NMDA receptor antagonist. Amantadine is also a useful building block in organic synthesis, allowing the insertion of an adamantyl group. Uses: Antiparkinson agents; antiviral agents; dopamine agents. Synonyms: adamantan-1-amine. Grade: > 95 %. CAS No. 768-94-5. Molecular formula: C10H17N. Mole weight: 151.25. | |
| Amantadine D6 | One of the isotopic labelled form of Amantadine, which is a NMDA-receptor antagonist. Synonyms: Tricyclo[3.3.1.13,7]decan-1-amine D6. Grade: 95% by HPLC; 98% atom D. Molecular formula: C10H11ND6. Mole weight: 157.29. | |
| Amantadine Hydrochloride | Amantadine Hydrochloride is a NMDA-receptor antagonist acts as an antiviral and an antiparkinsonian drug. Uses: Dopaminergic agent. antiviral. Synonyms: 1-Adamantanamine hydrochloride; adamantan-1-amine; hydrochloride. Grade: 95%. CAS No. 665-66-7. Molecular formula: C10H18ClN. Mole weight: 187.71. | |
| Amaranth | Amaranth is a food pigment additive, which can cause DNA damage difference in colon of rats and mice. Uses: Indicators and reagents. Synonyms: Bordeaux S; 1-(4-Sulfo-1-naphthylazo)-2-naphthol-3,6-disulfonic Acid Trisodium Salt; 1302 Red; 1508 Red; 2-Hydroxy-1,1'-azonaphthalene-3,6,4'-trisulfonic Acid Trisodium Salt; Acid Amaranth; Acid Amaranth I; Acid Amaranth J; Acid Amaranth N; Acid Leather Rubine S; Acid Red 27; Aizen Amaranth; Amaranth A; Amaranth B; Amaranth BPC; Amaranth Extra; Amaranth Lake; Amaranth R; Amaranth S; Amaranth red; Amaranthe; Azo Red R; Azo Rubine SF; Azo Ruby S; Azorubin S. Grade: >95%. CAS No. 915-67-3. Molecular formula: C20H11N2Na3O10S3. Mole weight: 604.47. | |
| Amastatin | Amastatin is a naturally occurring, competitive and reversible aminopeptidase inhibitor. Amastatin has originally been isolated from the culture filtrate of Streptomyces sp. Amastatin has been shown to slightly decrease the conversion of angiontensin II to angiotensin III, but significantly increases the potency of angiotensin III and des(Asp1)angiotensin I. Uses: Protease inhibitors. Synonyms: (2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl-val-val-asp-OH; [(2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-L-aspartic acid; (amino-2-hydroxy-5-methyl-hexanoyl)-L-valyl-L-valyl-L-aspartic acid. Grade: 95%. CAS No. 67655-94-1. Molecular formula: C21H38N4O8. Mole weight: 474.55. | |
| Amatuximab | Amatuximab is a humanized monoclonal antibody directed to mesothelin that kills mesothelin-expressing tumor cells by antibody-dependent cell-mediated cytotoxicity. Amatuximab blocks the binding of mesothelin to CA 125 and thus could be used also as a strategy to prevent tumor metastasis. Synonyms: MORab-009. CAS No. 931402-35-6. | |
| Amauromine | Amauromine is a potent and selective cannabinoid receptor CB1 (Ki = 178 nM; Kb = 66.6 nM) with antibiotic properties. It is a neutral antagonist with no activity at CB2 receptors at concentrations up to 10 μM. It is also an antagonist of GPR18 (IC50 = 3.74 μM). Amauromine has vasodilatory activity. Synonyms: FR 900220; WF 6237; Antibiotic FR 900220. Grade: ≥98%. CAS No. 88360-87-6. Molecular formula: C32H36N4O2. Mole weight: 508.7. | |
| Ambazone | Ambazone is an orally available antiseptic that is active against a variety of transplantable tumors in mice and rats. Synonyms: Hydrazinecarbothioamide, 2-[4-[2-(aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]-; 2-[4-[2-(Aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]hydrazinecarbothioamide; Guanidine, [(4-oxo-2,5-cyclohexadien-1-ylidene)amino]-, thiosemicarbazone; Hydrazinecarbothioamide, 2-[4-[(aminoiminomethyl)hydrazono]-2,5-cyclohexadien-1-ylidene]-; (4-Oxo-2,5-cyclohexadien-1-ylideneamino)guanidine thiosemicarbazone; 1,4-Benzoquinone amidinohydrazone thiosemicarbazone; 2-(4-(2-Carbamimidoylhydrazono)cyclohexa-2,5-dien-1-ylidene)hydrazinecarbothioamide; [(4-[[(Diaminomethylidene)amino]imino]cyclohexa-2,5-dien-1-ylidene)amino]thiourea; Ambazon; Anginon; Benzoquinone guanylhydrazone thiosemicarbazone; DC 0572; Faringosept; Guanothiazon; Inversal; Iversal; Ivertol; N-Guanidino-N'-thioureido-p-benzoquinonediimide; p-Benzoquinone amidinohydrazone thiosemicarbazone; Primal. Grade: 95%. CAS No. 539-21-9. Molecular formula: C8H11N7S. Mole weight: 237.28. | |
| Ambenonium | Ambenonium is a long-acting cholinesterase inhibitor used as a treatment of myasthenia gravis. The mechanism of Ambenonium is similar to neostigmine. Synonyms: Win-8077; N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium]. CAS No. 7648-98-8. Molecular formula: C28H42Cl2N4O2. Mole weight: 537.57. | |
| Ambenonium dichloride | Ambenonium dichloride is an extremely selective, potent and rapidly reversible inhibitor of acetylcholinesterase (AChE) with IC50 value of 0.000698 μM. It is used in the discovery and design of ApoE4 (apolipoprotein E4) inhibitors. It has biological activity showing against Alzheimer's disease. Uses: Parasympathomimetics. Synonyms: Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, chloride (1:2); [Oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethylammonium chloride]; Ammonium, [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethyl-, dichloride; Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, dichloride; Ambenonium chloride; Ambestigmin chloride; Misuran; Mysuran; Mysuran chloride; Mytelase; Mytelase chloride; N,N'-Bis-(2-diethylaminoethyl)oxamide bis-2-chlorobenzylchloride; N,N'-Bis-2-[(2-chlorobenzyl)diethylammonium chloride]-ethyloxamide; Oxamizil; Oxazil; Oxazyl; Win 8077. Grade: ≥99%. CAS No. 115-79-7. Molecular formula: C28H42Cl4N4O2. Mole weight: 608.48. | |
| Ambenonium dichloride tetrahydrate | Ambenonium dichloride tetrahydrate is an orally active and reversible inhibitor of Acetylcholinesterase (AChE) with high affinity. Synonyms: Ambenonium chloride tetrahydrate; Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-, dichloride, tetrahydrate; 2,2'-(oxalylbis(azanediyl))bis(N-(2-chlorobenzyl)-N,N-diethylethan-1-aminium) chloride tetrahydrate; 2,2'-[(1,2-Dioxo-1,2-ethanediyl)diimino]bis[N-(2-chlorobenzyl)-N,N-diethylethanaminium] chloride hydrate (1:2:4); Benzenemethanaminium, N,N'-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N',N'-diethyl-, chloride, hydrate (1:2:4). Grade: ≥95%. CAS No. 52022-31-8. Molecular formula: C28H42Cl4N4O2.4H2O. Mole weight: 680.53. | |
| AMBMP hydrochloride | The hydrochloride salt form of AMBMP, which has been found to be a Wnt canonical signaling activator and could probably be effective in the treatment of muscle dystrophy. Synonyms: N4-(1,3-Benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)-2,4-pyrimidinediamine hydrochloride. Grade: ≥98% by HPLC. CAS No. 2095432-75-8. Molecular formula: C19H18N4O3.HCl. Mole weight: 386.84. | |
| Ambrisentan Acyl β-D-Glucuronide | A metabolite of Ambrisentan. Synonyms: 1-[(αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoate] β-D-Glucopyranuronic Acid. Grade: > 95%. CAS No. 1106685-58-8. Molecular formula: C28H30N2O10. Mole weight: 554.56. | |
| Ambrisentan Hydroxy Acid Impurity | A metabolite of Ambrisentan. Synonyms: (S)-2-Hydroxy-3-methoxy-3,3-diphenylpropionic Acid. Grade: > 95%. CAS No. 178306-52-0. Molecular formula: C16H16O4. Mole weight: 272.3. | |
| Ambrisentan Impurity E | A metabolite of Ambrisentan. Synonyms: 2-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-3,3-diphenyl-2-propenoic Acid. Grade: > 95%. CAS No. 1312092-82-2. Molecular formula: C21H18N2O3. Mole weight: 346.39. | |
| Ambrisentan Vinyloxy Impurity | A metabolite of Ambrisentan. Synonyms: 2-((2,2-Diphenylvinyl)oxy)-4,6-dimethylpyrimidine. Grade: > 95%. CAS No. 1639429-81-4. Molecular formula: C20H18N2O. Mole weight: 302.38. | |
| Ambroxol Cycloimine | 5-ethyl 3-isopropyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate is an impurity of Ambroxol, a medication used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: (trans)-4-(6,8-dibromoquinazolin-3(4H)-yl)cyclohexanol; N-{[(2S)-1-Ethyl-2-pyrrolidinyl]methyl}-5-(ethylsulfonyl)-2-methoxy-4-(methylamino)benzamide; (1R,4R)-4-(6,8-dibromoquinazolin-3(4H)-yl)cyclohexan-1-ol; Ambroxol Cycloimine Impurity. CAS No. 2088879-81-4. Molecular formula: C18H29N3O4S. Mole weight: 383.51. | |
| Ambroxol Cycloimine Impurity | An impurity of Ambroxol. Synonyms: 4-(6,8-Dibromo-3(4H)-quinazolinyl)-cyclohexanol. Grade: > 95%. CAS No. 1797894-71-3. Molecular formula: C14H16Br2N2O. Mole weight: 388.1. | |
| Ambroxol EP Impurity B | An impurity of Ambroxol, a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: trans-4-(6,8-dibromo-1,4-dihydroquinazolin-3(2H)-yl)-cyclohexanol. Grade: > 95%. CAS No. 18683-95-9. Molecular formula: C14H18Br2N2O. Mole weight: 390.11. | |
| Ambroxol EP Impurity C | An impurity of Ambroxol, a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: trans-4-((2-Amino-3,5-dibromobenzylidene)amino)cyclohexanol; trans-4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]cyclohexanol; Cyclohexanol, 4-[[(2-Amino-3,5-dibromophenyl)methylene]amino]-, trans-. Grade: ≥95%. CAS No. 50910-53-7. Molecular formula: C13H16Br2N2O. Mole weight: 376.09. | |
| Ambroxol EP Impurity D | An impurity of Ambroxol, a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: rac-cis-Ambroxol. CAS No. 107814-37-9. Molecular formula: C13H18Br2N2O. Mole weight: 378.108. | |
| Ambroxol EP Impurity D HCl | An impurity of Ambroxol, a medication used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: cis-Ambroxol Hydrochloride. Grade: > 95%. CAS No. 1384955-66-1. Molecular formula: C13H18Br2N2O. HCl. Mole weight: 414.56. | |
| Ambroxol Monobromine | An impurity of Ambroxol, a medication used in the treatment of respiratory diseases associated with viscid or excessive mucus. Synonyms: trans-4-[[(2-Amino-5-bromophenyl)methyl]amino]-cyclohexanol. Grade: > 95%. CAS No. 101900-43-0. Molecular formula: C13H19BrN2O. Mole weight: 299.21. | |
| Ambutonium bromide | Ambutonium bromide, an acetylcholine antagonist, is used as an anticholinergic agent in ulcer therapy. Uses: A new anticholinergic drug. the new drug was superior to 0.6 mg. of atropine sulfate orally in its effects on gastric secretion and on gastric motility. Synonyms: BL700; γ-(Aminocarbonyl)-N-ethyl-N,N-dimethyl-γ-phenylbenzenepropanaminium Bromide; (3-Carbamoyl-3,3-diphenylpropyl)ethyldimethylammonium Bromide; 4-Dimethylamino-2,2-diphenylbutyramide Ethyl Bromide; Aludrox SA; BL 700; BL 700B; R 100; Benzenepropanaminium, gamma-(aminocarbonyl)-N-ethyl-N,N-dimethyl-gamma-phenyl-, bromide (1:1). Grade: 95%. CAS No. 115-51-5. Molecular formula: C20H27BrN2O. Mole weight: 391.35. | |
| AMCA-6-dUTP | AMCA-6-dUTP is a fluorescent probe commonly used in the biomedical industry to label DNA during various molecular biology applications. It can be incorporated into DNA using DNA polymerase and serving as a valuable tool for visualizing and studying DNA replication, repair and recombination. Synonyms: Aminoallyl-dUTP - AMCA; Aminomethylcoumarin-6-dUTP; Aminomethylcoumarin-5-aminoallyl-2'-deoxyuridine-5'-triphosphate, Triethylammonium salt. Grade: ≥ 95% by HPLC. Molecular formula: C30H40N5O18P3 (free acid). Mole weight: 851.58 (free acid). | |
| Amcenestrant | Amcenestrant is an orally available nonsteroidal selective estrogen receptor degrader (SERD). Amcenestrant was developed by Sanofi for the treatment of ER+/HER2- advanced or metastatic breast cancer. Synonyms: SAR439859; SAR-439859; SAR 439859. CAS No. 2114339-57-8. Molecular formula: C31H30Cl2FNO3. Mole weight: 554.48. | |
| Amcinonide | Amcinonide is a corticosteroid (IC50 = 3.38 nM) used as an anti-inflammatory and antipruritic agent. Uses: Anti-inflammatory agent. Synonyms: cl-34699; cyclocort; Amciderm; Amcinonid; Penticort. Grade: ≥98%. CAS No. 51022-69-6. Molecular formula: C28H35FO7. Mole weight: 502.58. | |
| AMD-070 | AMD-070 is a potent and selective antagonist of CXCR4 (with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay). Synonyms: (S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; AMD11070; AMD-11070; AMD 11070; AMD-070; AMD 070; AMD070. Grade: ≥98% (HPLC). CAS No. 558447-26-0. Molecular formula: C21H27N5. Mole weight: 349.47. | |
| AMD 3100 octahydrochloride | AMD 3100 octahydrochloride is a high selective CXCR4 chemokine receptor antagonist (IC50 values are 0.02 - 0.13 and > 25 μM for CXCR4 and all other chemokine receptors respectively). Uses: Anti-hiv agents. Synonyms: Plerixafor Octahydrochloride; Bicyclam; 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane octahydrochloride. Grade: >98%. CAS No. 155148-31-5. Molecular formula: C28H54N8.8HCl. Mole weight: 794.48. | |
| AMD-3451 | AMD-3451 is a dual CCR5/CXCR4 antagonist. It is the first low-molecular-weight anti-HIV drug with selective interaction between HIV co-receptors CCR5 and CXCR4. Synonyms: 1,4,8,11-Tetraazacyclotetradecane, 1-((2,6-Dichloro-4-Pyridinyl)Methyl)-; 935VV663H3; AMD3451. CAS No. 255383-10-9. Molecular formula: C16H27Cl2N5. Mole weight: 360.3. | |
| AMD 3465 | AMD 3465,a N-pyridinylmethylene monocyclam, is a selective antagonist of CXCL12/CXCR4-mediated interactions including ligand binding and receptor activation. With its enhanced potency against the CXCR4 receptor compared with plerixafor, AMD 3465 has been. Synonyms: N-(pyridin-2-ylmethyl)-1-[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methanamine; hexahydrobromideAMD 3465 hexahydrobromide185991-07-5185991-24-6AMD3465 6 HBrC24H38N6.6BrHAMD3465; AMD 3465; AMD-3465GENZ-644494 N-(1,4,8,11- tetraazacyclotetradecanyl-1,4-phenylen. Grade: ≥98%. CAS No. 185991-24-6. Molecular formula: C24H38N6. Mole weight: 410.60. | |
| AMD3465 hexahydrobromide | AMD 3465 is a potent and selective antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells. AMD 3465 (50 nM) totally blocks CXCL12-induced calcium mobilization, with an IC50 of 17 nM, but shows no effect on the intracellular calcium fluxes elicited by the CCR5 ligands RANTES, LD78β and MIP-1β in U87.CD4.CCR5 cells. MD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5. AMD3465 has the potential to mobilize hematopoietic stem cells. Synonyms: AMD3465; GENZ-644494 hexahydrobromide. Grade: ≥95%. CAS No. 185991-07-5. Molecular formula: C24H38N6·6HBr. Mole weight: 896.07. | |
| AMDE-1 | AMDE-1 is a modulator of autophagy activity. It acts by triggering autophagy in an Atg5-dependent manner, recruiting Atg16 to the pre-autophagosomal site and causing LC3 lipidation. Synonyms: AMDE 1; alpha-(3-Chlorophenyl)-5,7-bis(trifluoromethyl)-1,8-naphthyridine-2-acetonitrile; Autophagy Modulator with Dual Effect-1. CAS No. 478043-30-0. Molecular formula: C18H8ClF6N3. Mole weight: 415.72. | |
| Amdizalisib | Amdizalisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, an immunomodulator and an antineoplastic. Synonyms: (S)-4-amino-6-((1-(3-chloro-6-phenylimidazo[1,2-b]pyridazin-7-yl)ethyl)amino)pyrimidine-5-carbonitrile. Grade: 99% by HPLC. CAS No. 1894229-05-0. Molecular formula: C19H15ClN8. Mole weight: 390.83. | |
| Amdoxovir | Amdoxovir is a guanosine analogue that is active against HIV-1 and HBV. Synonyms: DAPD; beta-D-2,6-Diaminopurine-dioxolane. CAS No. 145514-04-1. Molecular formula: C9H12N6O3. Mole weight: 252.23. | |
| Amedalin Hydrochloride | Amedalin Hydrochloride, with antidepressant effect, is a selective norepinephrine reuptake inhibitor. Synonyms: 3-methyl-3-[3-(methylamino)propyl]-1-phenylindol-2-one; hydrochloride; Amedalin HCl. Grade: >98%. CAS No. 22232-73-1. Molecular formula: C19H23ClN2O. Mole weight: 330.85. | |
| Ameltolide | Ameltolide is an anticonvulsant agent, showing to be effective at inhibiting seizures in animal models. Synonyms: 4-Amino-2',6'-benzoxylidide; LY201116; LY-201116; LY 201116. CAS No. 787-93-9. Molecular formula: C15H16N2O. Mole weight: 240.30. | |
| Amenamevir | Amenamevir is a DNA helicase-primase inhibitor. It has anti-HSV activity against herpes simplex keratitis. In Mar 2016, Mahuro completed a phase III trial in Herpes simplex virus infections in Japan. Uses: Herpes simplex virus infections; herpes zoster. Synonyms: UNII-94X46KW4AE; ASP2151; N-(2,6-dimethylphenyl)-N-[2-[4-(1,2,4-oxadiazol-3-yl)anilino]-2-oxoethyl]-1,1-dioxothiane-4-carboxamide. Grade: 98%. CAS No. 841301-32-4. Molecular formula: C24H26N4O5S. Mole weight: 482.55. | |
| Ametantrone | Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding. Synonyms: CI881; CI 881; CI-881; NSC196473; NSC 287513; NSC-196473; NSC 287513; 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione. CAS No. 64862-96-0. Molecular formula: C22H28N4O4. Mole weight: 412.49. | |
| Ametantrone Acetate | Ametantrone is a topoisomerase II inhibitor of the anthrapyrazole family. It can cause covalent cross-links in DNA, so it can be used as a antineoplastic agent. Uses: Antineoplastic agent. Synonyms: CI-881; CI 881; CI881; NSC 287513; NSC-287513; NSC287513; 1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)anthracene-9,10-dione diacetate. Grade: 98%. CAS No. 70711-40-9. Molecular formula: C26H36N4O8. Mole weight: 532.59. | |
| Ametoctradin | Ametoctradin ist eine chemische Verbindung aus der Gruppe der Triazol-Pyrimidylamine. Synonyms: 5-Ethyl-6-octyl[1,2,4]?triazolo[1,5-a]pyrimidin-7-amin. Grade: > 95%. CAS No. 865318-97-4. Molecular formula: C15H25N5. Mole weight: 275.4. | |
| Amezinium methylsulfate | Amezinium methylsulfate, a sympathomimetic drug used for the treatment of low blood pressure, increases the arterial blood pressure and heart rate of anaesthetized animals and of pithed rats by stimulating vascular alpha- and cardiac beta 1-adrenoceptors. Synonyms: Amezinium Metilsulfate; LU-1631; LU 1631; LU1631; Regulton; Risumic. 6-methoxy-1-phenylpyridazin-1-ium-4-amine methylsulfate; AMEZINIUM METHYL SULFATE; SUPRATONIN (GRUNENTHAL); RISUMIC (DAINIPPON); REGULTON (KNOLL); 4-amino-6-methoxy-1-phenyl-pyridaziniumethylsulfate; 4-amino-6-methoxy-1-phenylpyridazinium-methylsulfat; 4-amino-. CAS No. 30578-37-1. Molecular formula: C11H12N3O.CH3O4S. Mole weight: 313.33. | |
| Amfenac | Amfenac (2-Amino-3-benzoylbenzeneacetic acid) is a non-steroidal anti-inflammatory drug with acetic acid moiety. Synonyms: 2-Amino-3-benzoylphenylacetic acid; 2-Amino-3-benzoylbenzeneacetic acid; 2-(2-amino-3-benzoyl-phenyl)acetic acid. Grade: > 95%. CAS No. 51579-82-9. Molecular formula: C15H13NO3. Mole weight: 255.28. | |
| Amfenac-[d5] Sodium Salt | Amfenac-[d5] Sodium Salt is a labelled sodium compound of Amfenac. Amfenac is a COX inhibitor with IC50 of 0.25 and 0.15 μM for COX-1 and COX-2, respectively. Synonyms: 2-Amino-3-(benzoyl-d5)benzeneacetic Acid Sodium Salt. Grade: 95% by HPLC; 98% atom D. Molecular formula: C15H7D5NNaO3. Mole weight: 282.28. | |
| Amfenac Lactam | A metabolite of Amfenac and Nepafenac. Synonyms: 7-Benzoyl-1,3-dihydro-2H-indol-2-one; 7-Benzoyl-2-indolinone. Grade: > 95%. CAS No. 51135-38-7. Molecular formula: C15H11NO2. Mole weight: 237.26. | |
| Amflutizole | Amflutizole is a xanthine oxidase inhibitor. It inhibits free radical generation in the ischemic/reperfused rat cerebral cortex. Synonyms: 4-Amino-3-(3-(trifluoromethyl)phenyl)isothiazole-5-carboxylic acid. CAS No. 82114-19-0. Molecular formula: C11H7F3N2O2S. Mole weight: 288.25. | |
| AMG-009 | AMG-009 is an orally active, small molecule dual D prostanoid(DP) receptor and chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist. It was in preclinical development for the treatment of asthma and allergic rhinitis. It was developed by Amgen Inc. Uses: Amg-009 was in preclinical development for the treatment of asthma and allergic rhinitis. Synonyms: AMG-009; AMG 009; AMG009; 2-[4-[4-(Butylcarbamoyl)-2-[(2,4-dichlorophenyl)sulfonylamino]phenoxy]-3-methoxyphenyl]acetic acid; AMG009; Benzeneacetic acid, 4-(4-((butylamino)carbonyl)-2-(((2,4-dichlorophenyl)sulfonyl)amino)phenoxy)-3-methoxy-. Grade: >98 %. CAS No. 1027847-67-1. Molecular formula: C26H26Cl2N2O7S. Mole weight: 581.46. | |
| AMG-1 | AMG-1 is a potent inhibitor of human c-Met and RON with IC50 of 4 nM and 9 nM, respectively. Synonyms: c-Met/RON Dual Kinase Inhibitor; RON-IN-1. CAS No. 913376-84-8. Molecular formula: C31H29FN4O5. Mole weight: 556.58. | |
| AMG-126737 | AMG-126737 is a potent inhibitor of human lung mast cell tryptase (Ki = 90 nM), with greater than 10- to 200-fold selectivity versus other serine proteases. Synonyms: 3-[[4-[5-[4-[[(3-carbamimidoylphenyl)sulfonylamino]methyl]phenoxy]pentoxy]phenyl]methylsulfamoyl]benzenecarboximidamide; 1,5-bis-(4-((3-carbamimidoyl-benzenesulfonylamino)-methyl)-phenoxy)-pentane; AMG-126737; AMG 126737; AMG126737. Grade: >98%. CAS No. 224054-76-6. Molecular formula: C33H38N6O6S2. Mole weight: 678.82. | |
| AMG 18 hydrochloride | AMG-18 hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM. AMG-18 is a potent and selective IRE1α inhibitor with IC50 of 13 nM for recombinant and IC50 of 99 nM for cellular IRE1α. Synonyms: 2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride; Kira8 hydrochloride. Grade: ≥98% by HPLC. Molecular formula: C31H29ClN6O3S·HCl. Mole weight: 637.58. | |
| AMG208 | AMG 208 is a selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase, plays an important role in epithelial cell proliferation and has been shown to be overexpressed in a variety of cancers. Synonyms: AMG-208; AMG208; AMG 208. Grade: 0.98. CAS No. 1002304-34-8. Molecular formula: C22H17N5O2. Mole weight: 383.411. | |
| AMG 21629 | AMG 21629 has been found to be an effective and selective TRPV1 antagonist, which could probably be useful in the treatment of pains associated with cancer and inflammatory diseases. Synonyms: AMG21629; AMG-21629; AMG 21629; 3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone. Grade: ≥97% by HPLC. CAS No. 939040-79-6. Molecular formula: C22H19F3N6O3. Mole weight: 472.42. | |
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