BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
H-D-Phe-Phe-Arg-chloromethyl ketone is a potent, specific and irreversible inhibitor of glandular and plasma kallikreins. Uses: Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Synonyms: FFRCK; Phenylalanyl-phenylalanyl-arginine chloromethyl ketone; Phe-phe-arg-CK; 2-Amino-N-[N-(6-carbamimidamido-1-chloro-2-oxohexan-3-yl)phenylalanyl]-3-phenylpropanimidic acid; PPACK II. CAS No. 74392-49-7. Molecular formula: C25H33ClN6O3. Mole weight: 501.02.
H-D-Phe-Pro-Arg-chloromethylketone
H-D-Phe-Pro-Arg-chloromethylketone is a highly effective and irreversible inhibitor of thrombin and gingipain R. Synonyms: PPACK; H-D-Phe-Pro-Arg-CH2Cl; fPR-CMK; D-phenylalanine-proline-arginine methyl chloride; D-Phe-Pro-Age-CMK; (S)-1-((R)-2-amino-3-phenylpropanoyl)-N-((S)-1-chloro-6-guanidino-2-oxohexan-3-yl)pyrrolidine-2-carboxamide; (S)-1-(D-phenylalanyl)-N-((S)-1-chloro-6-guanidino-2-oxohexan-3-yl)pyrrolidine-2-carboxamide; D-Phe-pro-arg-methyl chloride; D-Phenylalanyl-N-{(3S)-1-chloro-6-[(diaminomethylene)amino]-2-oxo-3-hexanyl}-L-prolinamide. Grades: ≥95% by HPLC. CAS No. 71142-71-7. Molecular formula: C21H31ClN6O3. Mole weight: 450.97.
H-D-Pro-Phe-Arg-pNA 2HCl
H-D-Pro-Phe-Arg-pNA 2HCl is a chromogenic substrate for the determination of plasma kallikrein-like activity. Synonyms: H-D-PFR-pNA 2HCl; L-Argininamide, D-prolyl-L-phenylalanyl-N-(4-nitrophenyl)-, dihydrochloride; D-Prolyl-L-phenylalanyl-N-(4-nitrophenyl)-L-argininamide hydrochloride (1:2); pFR-pNA dihydrochloride. Grades: 95%. CAS No. 62354-56-7. Molecular formula: C26H34N8O5.2HCl. Mole weight: 611.52.
The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. Synonyms: Pglu-pro-pro-gly-gly-ser-lys-val-ile-leu-phe; Hydra Peptide; HHAP. CAS No. 79943-68-3. Molecular formula: C54H84N12O14. Mole weight: 1125.33.
Hedamycin
It is produced by the strain of Streptomyces griseoruber. It is a quinone antibiotic. It has anti-gram-positive bacteria, negative bacterium, mycobacterium and yeast fungus activity (MIC is 0.031-3.2 μg/mL). 0.8 μg/mL of Hedamycin can inhibit Tetrahymena pyriformis. It also can inhibit rat duodenum adenocarcinoma, rats Walker 256 tumor (50 μg/kg/day), HeLa cell(IG50 is 0.00013 μg/mL), e. coli lysogenic W1709 (λ) phage (MIC is 0.0125 μg/mL). Synonyms: NSC-70929; Antibiotic B26158; 4H-Anthra(1,2-b)pyran-4,7,12-trione, 2-(3,3'-dimethyl(2,2'-bioxiran)-3-yl)-11-hydroxy-5-methyl-8-(2,3,6-trideoxy-3-(dimethylamino)-beta-D-arabino-hexopyranosyl)-10-(2,3,6-trideoxy-3-(dimethylamino)-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-. Grades: ≥95%. CAS No. 11048-97-8. Molecular formula: C41H50N2O11. Mole weight: 746.85.
Heliantriol B2
Heliantriol B2 is a natural compound which can be isolated from Chuquiraga erinacea and Monteverdia apurimacensis, etc. Synonyms: Lup-20(29)-ene-3,16,28-triol. Grades: 98%. CAS No. 61229-18-3. Molecular formula: C30H50O3. Mole weight: 458.71.
Hemokinin 1 (mouse) acetate
Hemokinin 1 (mouse) acetate is a mammalian endogenous peptide and a homolog of substance P. Hemokinin 1 (mouse) acts as a high affinity and selective agonist at the tachykinin NK1 receptor (Ki = 0.175 and 560 nM for NK1 and NK2 receptors, respectively). It induces the proliferation of B-cells in vitro and exhibits antihypertensive activity in vivo. Synonyms: H-Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2.CH3CO2H; L-arginyl-L-seryl-L-arginyl-L-threonyl-L-arginyl-L-glutaminyl-L-phenylalanyl-L-tyrosyl-glycyl-L-leucyl-L-methioninamide acetic acid; Hemokinin-1 (rat gene PPT-C) acetate. Grades: ≥95%. Molecular formula: C63H104N22O17S. Mole weight: 1473.72.
Hemopressin (human, mouse) acetate
Hemopressin (human, mouse) acetate, derived from the α1-chain of hemoglobin and originally isolated from rat brain homogenates, is a bioactive endogenous peptide substrate for endopeptidase 24.15, neurolysin and ACE (Ki = 27.76, 3.43 and 1.87 μM, respectively). It acts as a selective CB1 receptor inverse agonist with antinociceptive and hypotensive activity. Synonyms: H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH.CH3CO2H; L-prolyl-L-valyl-L-asparagyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-L-histidine acetic acid. Grades: ≥95%. Molecular formula: C52H83N13O14. Mole weight: 1114.29.
Heneicomycin
It is produced by the strain of Streptomyces filipinensis MA-4581 (NRRL 11044). It has anti-gram-positive bacteria, negative bacteria and mycoplasma activities, and has the effect of promoting animal growth. Synonyms: 2H-Pyran-2-acetamide, N-((2E,4E,6S,7R)-7-((2S,3S,4R,5R)-5-((1E,3E,5E)-7-(1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl)tetrahydro-3,4-dihydroxy-2-furanyl)-6-methoxy-5-methyl-2,4-octadienyl)-alpha-ethyltetrahydro-2,4-dihydroxy-5,5-dimethyl-6-((1E,3Z)-1,3-pentadienyl)-, (alphaS,2S,4S,6S)-; 30-Deoxy-1-methylmocimycin; Antibiotic A 21A. CAS No. 66170-37-4. Molecular formula: C44H62N2O11. Mole weight: 794.98.
Hepcidin-1 (mouse)
Two kinds of hepcidin are found in mice. Hepcidin-1, a homolog of human Hepcidin-25 in serum, may be involved in murine brain iron metabolism. Hepcidin-2 is a pentapeptide with different sequences in urine. Synonyms: H-Asp-Thr-Asn-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Lys-Cys-Cys-Asn-Asn-Ser-Gln-Cys-Gly-Ile-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys22, Cys11-Cys19, Cys13-Cys14); L-alpha-aspartyl-L-threonyl-L-asparagyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-cysteinyl-L-cysteinyl-L-asparagyl-L-asparagyl-L-seryl-L-glutaminyl-L-cysteinyl-glycyl-L-isoleucyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (7->23),(10->22),(11->19),(13->14)-tetrakis(disulfide); L-α-Aspartyl-L-threonyl-L-asparaginyl-L-phenylalanyl-L-prolyl-N-[(1R, 4R, 7S, 10S, 13R, 18R, 21R, 24S, 30R, 33S, 36S, 39S, 42S, 45R, 50R, 53S)-53-(4-aminobutyl)-18-{[(2S)-6-amino-1-{[(1S, 2R)-1-carboxy-2-hydroxypropyl]amino}-1-oxo-2-hexanyl]carbamoyl}-39, 42-bis(2-amino-2-oxoethyl)-33-(3-amino-3-oxopropyl)-7-benzyl-10, 24-di[(2S)-2-butanyl]-36-(hydroxymethyl)-3, 6, 9, 12, 20, 23, 26, 29, 32, 35, 38, 41, 44, 52, 55, 60-hexadecaoxo-15, 16, 47, 48, 57, 58, 63, 64-octathia-2, 5, 8, 11, 19, 22, 25, 28, 31, 34, 37, 40, 43, 51, 54, 61-hexadecaazatetracyclo[28.25.4.44, 21.245, 50]pentahexacont-13-yl]-L-isoleucinamide. Grades: ≥95%. CAS No. 1676104-75-8. Molecular formula: C111H169N31O35S8. Mole weight: 2754.28.
Hepcidin-22 (human)
Hepcidin-22 (human) is an inactive degradation product of Hepcidin-25 found in human urine. Synonyms: H-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys4-Cys10, Cys7-Cys20, Cys8-Cys19, Cys11-Cys16, air oxidized); L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-glycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinyl-glycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (4->10),(7->20),(8->19),(11->16)-tetrakis(disulfide). Grades: ≥95%. CAS No. 342790-22-1. Molecular formula: C99H151N29O25S9. Mole weight: 2436.06.
Hepcidin-24 (human)
Hepcidin-24, an excellent substitute for biotinylated or heavy isotope-labeled hepcidin-25, is used as an internal reference in the determination of Hep-25 by mass spectrometry-based methods, for example in human serum or urine. Synonyms: H-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys6-Cys22, Cys9-Cys12, Cys10-Cys18, Cys13-Cys21, air oxidized); des-Asp1-Hepcidin-24. Grades: ≥95%. Molecular formula: C109H165N33O28S9. Mole weight: 2674.31.
Hepcidin-25 (human)
Hepcidin-25 (hepatic bactericidal protein), also known as LEAP-1 (liver-expressed antimicrobial peptide), is found independently in human blood ultrafiltration and urine. It is mainly expressed in liver and belongs to a new family of small vertebrate antimicrobial peptides that contain 8 cysteine residues and has obvious antibacterial and antifungal activities. Hepcidin is the main human iron regulatory hormone, which can bind to iron exporter ferroportin and induce its internalization and degradation, thus blocking iron efflux from cells. Uses: Anti-infective agents. Synonyms: LEAP-1 (human); H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH (Disulfide bridge: Cys7-Cys23, Cys10-Cys13, Cys11-Cys19, Cys14-Cys22); L-alpha-aspartyl-L-threonyl-L-histidyl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-cysteinyl-L-isoleucyl-L-phenylalanyl-L-cysteinyl-L-cysteinyl-glycyl-L-cysteinyl-L-cysteinyl-L-histidyl-L-arginyl-L-seryl-L-lysyl-L-cysteinyl-glycyl-L-methionyl-L-cysteinyl-L-cysteinyl-L-lysyl-L-threonine (7->23),(10->13),(11->19),(14->22)-tetrakis(disulfide); Hepcidin Hepc25 (human); Hepcidin-25. Grades: ≥95% by HPLC. CAS No. 1356390-47-0. Molecular formula: C113H170N34O31S9. Mole weight: 2789.35.
Herbarin
It is produced by the strain of Torula herbarum. It is a quinone antibiotic. Herbarin complex has anti-gram-positive bacteria, negative bacteria, citrus canker xanthomonas, potato early blight, aspergillus Niger, Decaprous and other fungal activities. Synonyms: dehydroherbarin; Ambotz; 1H-Naphtho(2,3-c)pyran-5,10-dione,3,4-dihydro-3-hydroxy-7,9-dimethoxy-3-methyl-; 3-Hydroxy-7,9-dimethoxy-3-methyl-3,4-dihydro-1H-naphtho[2,3-c]pyran-5,10-dione. Grades: 97%. CAS No. 36379-67-6. Molecular formula: C16H16O6. Mole weight: 304.30.
Herboxidiene
Herboxidiene is a substance with herbicidal activity produced by Streptomyces chromofuscus. It has selective and powerful weeding effect on a variety of monocot and dicot weeds. Synonyms: Herboxidiene. Grades: 98%. CAS No. 142861-00-5. Molecular formula: C25H42O6. Mole weight: 438.60.
Herical
Herical is a diterpene xyloside produced by Hericium clathroides. Synonyms: Erinacine P. CAS No. 291532-17-7. Molecular formula: C27H40O8. Mole weight: 492.60.
HEX3 acetate is a fragment of the adenoviral hexon which is the major capsid protein found in Adenoviruses and is comprised of three identical polypeptide chains. Synonyms: L-Isoleucine, L-lysyl-L-tyrosyl-L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-valyl-L-lysyl-, acetate salt (1:1); L-Lysyl-L-tyrosyl-L-seryl-L-prolyl-L-seryl-L-asparaginyl-L-valyl-L-lysyl-L-isoleucine acetate salt; Lys-Tyr-Ser-Pro-Ser-Asn-Val-Lys-Ile acetate salt. Grades: ≥95%. Molecular formula: C47H78N12O14.C2H4O2. Mole weight: 1095.26.
Hexacyclinol
Hexacycline is a natural metabolite of the fungus Panus rudis HKI 0254. It has moderate anti-Gram-positive bacteria activity, 4-40μg/mL can inhibit the production of oxidants by polymorphonuclear neutrophils (PMNL) stimulated by zymosan. It inhibits the growth of L-930 and K 562 cells with IC50 of 1.4μg/mL and 0.4μg/mL, respectively, and the IC50 of HeLa cells is 10μg/mL. It also has an anti-Plasmodium effect, and its IC50 for Plasmodium falciparum is 2.4μg/mL. Synonyms: (+)-Hexacyclinol. Molecular formula: C23H28O7. Mole weight: 416.47.
Hexapeptide-10 Acetate is a synthetic peptide. It increases the synthesis of laminin V and α6-integrin to promote cell binding, with extraordinary visible skin restructuring and firming abilities. Molecular formula: C30H57N7O10. Mole weight: 675.81.
Hexapeptide-9 Acetate
Hexapeptide-9 is an anti-aging hexapeptide that helps strengthening structural tissues by naturally interacting with skin cells thereby promoting the rejuvenation process. Molecular formula: C26H42N8O11. Mole weight: 642.66.
Hexoprenaline
Hexoprenaline is a selective β2 adrenergic receptor agonist used in the treatment of asthma. It is also used in some countries as a tocolytic agent and a vasoactive agent. Uses: Bronchodilator agents. Synonyms: 4,4'-[1,6-Hexanediylbis[imino(1-hydroxy-2,1-ethanediyl)]]bis-1,2-benzenediol; α , α '-[hexamethylenebis (iminomethylene)]bis[3, 4-dihydroxybenzyl Alcohol; Broncholysin; Byk 1512; Ipradol; N,N'-Bis[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]hexamethylenediamine; ST 1512. Grades: > 95%. CAS No. 3215-70-1. Molecular formula: C22H32N2O6. Mole weight: 420.51.
Hexylitaconic acid is a plant growth regulator produced by Aspergillus niger K-88. It has the effect of stimulating plant growth. Synonyms: (-)-Hexylitaconic acid. Molecular formula: C11H18O4. Mole weight: 214.26.
H-γ-GLU-GLN-OH
H-γ-GLU-GLN-OH is an intestinal metabolite which may be related to myocardial infarction in rats. Synonyms: gamma-Glutamylglutamine; (5-L-Glutamyl)-L-glutamine; H-Glu(Gln-OH)-OH; N2-gamma-Glutamylglutamine; N2-L-γ-Glutamyl-L-glutamine. CAS No. 10148-81-9. Molecular formula: C10H17N3O6. Mole weight: 275.26.
H-Gln-Gln-OH
It is a substrate for glutaminyl cyclase. Synonyms: Gln-Gln; Glutaminyl-Glutamine; QQ dipeptide; L-Gln-L-Gln; Glutamine Glutamine dipeptide. CAS No. 54419-93-1. Molecular formula: C10H18N4O5. Mole weight: 274.27.
H-Gln-Glu-OH
H-Gln-Glu-OH can be used to study the metal binding affinity between Nickel (II) and oligopeptides containing aspartyl and glutamyl residues. Synonyms: Gln-Glu; L-glutaminyl-L-glutamic acid; QE dipeptide; L-Gln-L-Glu; Glutamine Glutamate dipeptide. CAS No. 88830-90-4. Molecular formula: C10H17N3O6. Mole weight: 275.26.
H-Glu[cyclo(-Arg-Gly-Asp-D-Phe-Lys)]-cyclo(-Arg-Gly-Asp-D-Phe-Lys) is the dimeric form of c(RGDfK), which has better tumor-targeting properties than the monomer. It binds readily to dyes, drug molecules, or chelators. The 68Ga complex of DOTA-E(c(RGDfK))2 has been evaluated as a therapeutic radiopharmaceutical. Synonyms: Cyclo[D-Phe-N6-[N5-[3-[[cyclo(L-Ala-L-Arg-Gly-L-Asp-D-Phe-)]-3-yl]propyl]-L-Gln-]-L-Lys-L-Arg-Gly-L-Asp-]; E(c(RGDfK))2; SU 016. Grades: ≥95%. CAS No. 250612-47-6. Molecular formula: C59H87N19O16. Mole weight: 1318.44.
H-Glu(EDANS)-Pro-Leu-Phe-Ala-Glu-Arg-Lys(DABCYL)-OH is an internally quenched substrate for calpain-1 (μ-calpain) with optimal cleavage motifs flanking the scissile bond. The turnover rate of the enzyme to hydrolysis of this FRET substrate based on the PLFAER amino acid sequence is more than 18 times higher than that of EVYGMM derived from the natural substrate α-spectrin cleavage site. Synonyms: N- ({5-[ (2-Aminoethyl) amino]-1-naphthyl}sulfonyl) -L-α -glutamyl-L-prolyl-L-leucyl-L-phenylalanyl-L-alanyl-L-α -glutamyl-L-arginyl-N6- (4-{[4- (dimethylamino) phenyl]diazenyl}benzoyl) -L-lysine. Grades: ≥95%. CAS No. 1914987-47-5. Molecular formula: C72H97N17O16S. Mole weight: 1488.71.
H-Gly-Arg-Gly-Asp-Ser-NH2 can be coupled to the carrier via its free N-terminal. Synonyms: GRGDS-amide; H-GRGDS-NH2; (3S)-3-{[2-({(2S)-2-[(2-Amino-1-hydroxyethylidene)amino]-5-carbamimidamido-1-hydroxypentylidene}amino)-1-hydroxyethylidene]amino}-4-{[(2S)-1,3-dihydroxy-1-imino-2-propanyl]imino}-4-hydroxybutanoic acid; glycyl-L-arginyl-glycyl-L-alpha-aspartyl-L-serinamide. Grades: ≥95%. CAS No. 143648-02-6. Molecular formula: C17H31N9O8. Mole weight: 489.48.
H-Gly-Arg-Gly-Glu-Ser-OH
H-Gly-Arg-Gly-Glu-Ser-OH is an active peptide fragment of fibronectin, a glycoprotein that interacts with integrins. Synonyms: H-GRGES-OH; glycyl-L-arginyl-glycyl-L-alpha-glutamyl-L-serine; L-Serine, glycyl-L-arginylglycyl-L-α-glutamyl-; Glycyl-N5-(diaminomethylene)-L-ornithylglycyl-L-α-glutamyl-L-serine; (6S,12S,15S)-1-amino-6-(2-aminoacetamido)-12-(2-carboxyethyl)-15-(hydroxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oic acid; Fibronectin Active Fragment Control. Grades: ≥90%. CAS No. 97461-84-2. Molecular formula: C18H32N8O9. Mole weight: 504.49.
H-Gly-Arg-Gly-Glu-Ser-Pro-OH
H-Gly-Arg-Gly-Glu-Ser-Pro-OH is an inactive fibronectin fragment analog used as a control for tests with GRGDSP. Synonyms: H-GRGESP-OH; glycyl-L-arginyl-glycyl-L-alpha-glutamyl-L-seryl-L-proline; L-Proline, 1-(N-(N-(N-(N2-glycyl-L-arginyl)glycyl)-L-alpha-glutamyl)-L-seryl)-; Glycyl-N5-(diaminomethylene)-L-ornithylglycyl-L-α-glutamyl-L-seryl-L-proline; (S)-1-((6S,12S,15S)-1-amino-6-(2-aminoacetamido)-12-(2-carboxyethyl)-15-(hydroxymethyl)-1-imino-7,10,13-trioxo-2,8,11,14-tetraazahexadecan-16-oyl)pyrrolidine-2-carboxylic acid. Grades: ≥95%. CAS No. 99896-88-5. Molecular formula: C23H39N9O10. Mole weight: 601.61.
H-Gly-D-Gln-OH is a potential impurity of glycyl-L-glutamine used in parenteral nutrition. Synonyms: glycyl-d-glutamine. CAS No. 115588-13-1. Molecular formula: C7H13N3O4. Mole weight: 203.20.
H-Gly-D-Tyr-OH
H-Gly-D-Tyr-OH is a potential impurity of glycyl-L-tyrosine for parenteral nutrition and is used in the synthesis of solid phase peptides. Synonyms: glycyl-D-tyrosine; N-Glycyl-D-tyrosine; Gly-(D-Tyr). CAS No. 133706-65-7. Molecular formula: C11H14N2O4. Mole weight: 238.24.
H-Gly-Gly-Cys-OH inhibits carboxypeptidase U (thrombin activatable fibrinolysis inhibitor, TAFI), though less efficiently than the dipeptide GC; Ki 0.99 μm. Synonyms: Glycyl-glycyl-cysteine; Gly-gly-cys; glycyl-glycyl-l-cysteine; L-Cysteine, N-(N-glycylglycyl)-. CAS No. 95416-30-1. Molecular formula: C7H13N3O4S. Mole weight: 235.26.
H-Gly-Gly-His-OH
Diglycyl-histidine has been used in biosensors for the electrochemical detection of Cu(II) ions. Synonyms: Diglycyl-histidine; Glycylglycyl-L-histidine; Gly-gly-his; (S)-2-(2-(2-Aminoacetamido)acetamido)-3-(1H-imidazol-4-yl)propanoic acid. CAS No. 7451-76-5. Molecular formula: C10H15N5O4. Mole weight: 269.26.
The fibrin central E region contains two sets of polymeric knobs A and B, which are hidden in fibrinogen but are exposed after thrombin cleavage of fibrinopeptide A (FpA) and fibrinopeptide B (FpB) from the N-terminus of the Aα- and Bβ-chains, respectively. The location of the binding holes and possible models for knob-hole interactions can be known by X-ray crystallographic studies using synthetic peptide analogs of knobs A and B. When fibrinogen fragment D and dual D are crystallized in the presence of two peptide analogs, the knob A peptide mimic H-Gly-Pro-Arg-Pro-NH2 (GPRP-amide) interacts with residues γ364Asp, γ330Asp, γ329Gln, and γ340His found in hole a to form H bonds, the knob B peptide mimic H-Gly-His-Arg-Pro-NH2 (GHRP-amide) interacts with Bβ397Glu, Bβ398Asp, and Bβ432Asp in hole b. Synonyms: GHRP amide; H-GHRP-NH2; glycyl-L-histidyl-L-arginyl-L-prolinamide; Glycyl-L-histidyl-N5-(diaminomethylene)-L-ornithyl-L-prolinamide; (S)-1-((S)-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)-5-guanidinopentanoyl)pyrrolidine-2-carboxamide. Grades: ≥95%. CAS No. 209623-54-1. Molecular formula: C19H32N10O4. Mole weight: 464.53.