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Z-Pro-Pro-aldehyde-dimethyl acetal
Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PEP), a cytoplasmic serine endoprotease (IC50= 120 μM). Synonyms: Z-PP-CHO. Grades: >98%. CAS No. 170116-63-9. Molecular formula: C20H28N2O5. Mole weight: 376.45.
(Z)-rac-Luliconazole
(Z)-rac-Luliconazole is a stereoisomer of Luliconazole which is an azole antifungal drug. Synonyms: (Z)-α-[4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile. Grades: > 95%. CAS No. 101529-76-4. Molecular formula: C14H9Cl2N3S2. Mole weight: 354.28.
The presence of halogen substituents on the fluorescent group improves the membrane permeability of YVAD-derived Caspase-1 substrate Z-YVAD-AFC. Synonyms: L-a-Asparagine, N-[(phenylmethoxy)carbonyl]-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-; N-[(Benzyloxy)carbonyl]-L-tyrosyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]-L-α-asparagine; Caspase-1 Substrate (AFC); Z-YVAD-AFC. Grades: ≥90%. CAS No. 201608-13-1. Molecular formula: C39H40F3N5O11. Mole weight: 811.76.
Z-Tyr-Val-Ala-DL-Asp-fluoromethylketone
Z-YVAD-FMK is a cell-permeable potent irreversible inhibitor of caspase-1 and -4. Synonyms: Z-YVAD-FMK. CAS No. 1926163-56-5. Molecular formula: C31H37FN4O10. Mole weight: 616.64.
Z-Val-Ala-Asn-AMC
Z-Val-Ala-Asn-AMC is a substrate for the determination of cysteine endopeptidase required for antigen processing and has been used as a fluorescent substrate for porcine asparaginyl endopeptidase (AEP, legumain). Synonyms: Cbz-Val-Ala-Asn-AMC; L-Aspartamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-alanyl-N1-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-; Z-VAN-AMC; Butanediimidic acid, 2- [ [ (2S) -1-hydroxy-2- [ [ (2S) -1-hydroxy-2- [ [hydroxy (phenylmethoxy) methylene] amino] -3-methylbutylidene] amino] propylidene] amino] -N1- (4-methyl-2-oxo-2H-1-benzopyran-7-yl) -, (2S)-; benzyl ((S)-1-(((S)-1-(((S)-4-amino-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1,4-dioxobutan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate. Grades: ≥95%. CAS No. 245036-58-2. Molecular formula: C30H35N5O8. Mole weight: 593.64.
Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone
Z-VAD-FMK is an irreversible tripeptide inhibitor of all caspases, useful in studies involving enzymes. Synonyms: Z-vad-FMK; N-[(Phenylmethoxy)carbonyl]-L-valyl-N-[3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-alaninamide; benzyloxycarbonyl-Val-Ala-DL-Asp(O-methyl)-fluoromethyl ketone. CAS No. 634911-81-2. Molecular formula: C22H30FN3O7. Mole weight: 467.49.
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone, a cell-permeable and irreversible inhibitor of para-caspase MALT1, is based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9. Synonyms: MALT1 Inhibitor; Z-VRPR-FMK; L-Prolinamide, N-[(phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-; Cbz-Val-Arg-Pro-DL-Arg-CH2F; N-[(Phenylmethoxy)carbonyl]-L-valyl-L-arginyl-N-[4-[(aminoiminomethyl)amino]-1-(2-fluoroacetyl)butyl]-L-prolinamide. Grades: ≥95%. CAS No. 1926163-57-6. Molecular formula: C31H49FN10O6. Mole weight: 676.79.
Z-Val-Asp(OMe)-Val-Ala-DL-Asp(OMe)-fluoromethylketone is a cell-permeable fluoromethylketone that specifically inhibits caspase-2 and, to a lesser extent, caspase-3 and caspase-7. Synonyms: Z-VD(OMe)VAD(OMe)-FMK; Z-VDVA-(DL-Asp)-FMK; Methyl (5S,8S,11S,14S)-17-(fluoroacetyl)-5,11-diisopropyl-8-(2-methoxy-2-oxoethyl)-14-methyl-3,6,9,12,15-pentaoxo-1-phenyl-2-oxa-4,7,10,13,16-pentaazanonadecan-19-oate. Grades: ≥90%. CAS No. 1926163-61-2. Molecular formula: C32H46FN5O11. Mole weight: 695.73.