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Verucopeptin
It is an antibiotic produced by the strain of Actinomadura verrucosospora Q886-2. It has weak antimicrobial effect and can prolong the survival time of mice transplanted with melanoma. Verucopeptin strongly inhibits v-ATPase activity by directly targeting the v-ATPase ATP6V1G subunit but not ATP1V1B2 or ATP6V1D. Synonyms: 2-hydroxy-N-(17-hydroxy-8,14-dimethyl-2,6,9,12,15,18-hexaoxo-4-propan-2-yl-5-oxa-1,8,11,14,17,23-hexazabicyclo[17.4.0]tricosan-3-yl)-2-[2-hydroxy-5-methoxy-6-[(E)-4,6,8-trimethyldec-2-en-2-yl]oxan-2-yl]propanamide. Grades: 98%. CAS No. 138067-14-8. Molecular formula: C43H73N7O13. Mole weight: 896.08.
Vesicular Stomatitis Virus Nucleoprotein (52-59)
Vesicular Stomatitis Virus Nucleoprotein (52-59) (VSV-8), corresponding to positions 52 to 59 of the vesicular stomatitis virus (VSV) nuclear protein, is expressed in the cytosol of VSV-infected cells. CTL response to VSV in H-2Kb mice is directed against this immunodominant peptide. VSV-8 forms a complex with the mouse MHC Class I molecule H-2Kb, similar to the human HLA Class I. Synonyms: VSV-8; H-Arg-Gly-Tyr-Val-Tyr-Gln-Gly-Leu-OH; L-Leucine, L-arginylglycyl-L-tyrosyl-L-valyl-L-tyrosyl-L-glutaminylglycyl-; N5-(Diaminomethylene)-L-ornithylglycyl-L-tyrosyl-L-valyl-L-tyrosyl-L-glutaminylglycyl-L-leucine. Grades: ≥95%. CAS No. 132326-74-0. Molecular formula: C44H66N12O12. Mole weight: 955.08.
Viburgenin
Viburgenin, an extract isolated from Rudgea viburnioides, is a triterpenes that shows an antifungal and anticancer activity. Synonyms: (+)-Viburgenin. CAS No. 211506-71-7. Molecular formula: C30H50O5. Mole weight: 490.73.
Vicanicin
Vicanicin is a depsidone isolated from the lichen Teloschistesflavicans (Sw.) Norm. Vicanicin can induce apoptosis of DU-145 and LNCaP cells. Synonyms: 2,7-Dichloro-3-hydroxy-8-methoxy-1,4,6,9-tetramethyl-11H-dibenzo[b,e][1,4]dioxepin-11-one. CAS No. 33211-22-2. Molecular formula: C18H16Cl2O5. Mole weight: 383.22.
Vicenistatin M
It is produced by the strain of Streptomyces sp. HC-34. It is a homologue of Mycarose replacing amino sugars in the Vicenstatin molecule, and it loses the cytotoxicity of Vicenstatin. Synonyms: (6S,7S,18S)-20-aza-6,10,12,18-tetramethyl-7-O-(2',6'-dideoxy-3'-C-methyl-β-D-ribo-hexopyranosyl)-cycloicosa-2,4,9,12,14-pentaen-1-one; (3E,5E,10E,13E,15E)-(7S,8S,19S)-8-((2R,4S,5R,6R)-4,5-Dihydroxy-4,6-dimethyl-tetrahydro-pyran-2-yloxy)-7,11,13,19-tetramethyl-azacycloicosa-3,5,10,13,15-pentaen-2-one; Vicenistatine M. CAS No. 312532-50-6. Molecular formula: C30H47NO5. Mole weight: 501.70.
Vinetorin
Vinetorin is a xanthone compound. Synonyms: Xanthen-9-one, 4-chloro-3,8-dihydroxy-6-methoxy-1-methyl- (8CI); 4-Chloro-3,8-dihydroxy-6-methoxy-1-methyl-9H-xanthen-9-one. CAS No. 23460-01-7. Molecular formula: C15H11ClO5. Mole weight: 306.7.
Vinyl Lactone Analogue of Mycophenolic Acid
An impurity of Mycophenolic which is a potent IMPDH inhibitor and the active metabolite of an immunosuppressive drug. Grades: > 95%. Molecular formula: C17H18O6. Mole weight: 318.33.
Vinyl resin
Vinyl resin is a polymer based on the polymerization of vinyl chloride and is widely used in surface coatings. Vinyl resin is also used in caulking and casting compounds, sealants, paints, and other industrial applications to prevent corrosion.
Viomycin sulfate
It is a peptide antibiotic produced by the strain of Str. puniceus 1314-5 and Str. floridae A5014. It has broad-spectrum antibacterial and strong anti-mycobacterium effect. 1-10 μg/mL of Viomycin can inhibit the growth of most tuberculosis bacilli, the main effect is to inhibit the protein synthesis of bacteria, but bacteria are prone to develop drug resistance. In clinical application, it is only used as a second-line drug to treat tuberculosis. Synonyms: Tuberactinomycin B sulfate salt; celicomycin-sulfate; florimycin sulfate; Vinacetin A sulfate; hexanamide, 3,6-diamino-N-[(3S,6Z,9S,12S,15S)-6-[[(aminocarbonyl)amino]methylene]-3-[(4R,6S)-2-amino-3,4,5,6-tetrahydro-6-hydroxy-4-pyrimidinyl]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadec-15-yl]-, (3S)-, sulfate (1:1) (salt). CAS No. 37883-00-4. Molecular formula: C25H43N13O10.H2O4S. Mole weight: 783.77.
VIP Antagonist
VIP antagonist, a hybrid of neurotensin (6-11) and VIP (7-28), is a competitive antagonist of VIP-binding to glial cells. In rats with reduced masculine potency, it significantly inhibits VIP-stimulated sexual behavior. It antagonizes VIP receptors on non-small cell lung cancer cells, thereby inhibiting tumor growth in vivo and in vitro. Synonyms: [Lys1,Pro2,5,Arg3,4,Tyr6]VIP, human, porcine, rat, ovine; H-Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2; L-lysyl-L-prolyl-L-arginyl-L-arginyl-L-prolyl-L-tyrosyl-L-threonyl-L-alpha-aspartyl-L-asparagyl-L-tyrosyl-L-threonyl-L-arginyl-L-leucyl-L-arginyl-L-lysyl-L-glutaminyl-L-methionyl-L-alanyl-L-valyl-L-lysyl-L-lysyl-L-tyrosyl-L-leucyl-L-asparagyl-L-seryl-L-isoleucyl-L-leucyl-L-asparaginamide; [Lys1,Pro2,5,Arg3,4,Tyr6]-Vasoactive Intestinal Peptide human, porcine, rat. Grades: 95%. CAS No. 125093-93-8. Molecular formula: C154H257N49O40S. Mole weight: 3467.06.
Virantmycin
It is produced by the strain of Str. nitrosporeus AM-2722. It has antiviral effect. It inhibits four RNA viruses and four DNA viruses with MIC (μg/mL) of 0.008-0.04 and 0.005-0.03, respectively. It has weak antifungal effect. Synonyms: 6-Quinolinecarboxylic acid, 3-chloro-2-(3,4-dimethyl-3-penten-1-yl)-1,2,3,4-tetrahydro-2-(methoxymethyl)-, (2R,3R)-; NSC 374127; 6-Quinolinecarboxylic acid, 3-chloro-2-(3,4-dimethyl-3-pentenyl)-1,2,3,4-tetrahydro-2-(methoxymethyl)-, (2R-cis)-; (-)-Virantmycin. Grades: 99%. CAS No. 76417-04-4. Molecular formula: C19H26C1NO3. Mole weight: 351.87.
(?)-Viriditoxin
(-)-Viriditoxin is a mycotoxin originally isolated from A. viridinutans. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2μg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50 = 7.0 μg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria. Synonyms: UNII-6TAK972FMC; 6TAK972FMC. Grades: ≥98%. CAS No. 1381782-08-6. Molecular formula: C34H30O14. Mole weight: 662.59.
Vitamin D3
Cholecalciferol is a naturally occurring form of vitamin D which is obtained from dietary sources, such as fish, or through the conversion of 7-dehydrocholesterol by ultraviolet light. It is subsequently metabolized to 25-hydroxyvitamin D3 and the active form 1,25-dihydroxyvitamin D3 by cytochrome P450 isoforms in the liver. It could prevent proliferation of cancer cells. Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol; Cholecalciferol; Duphafral D3 1000; Delsterol; Deparal; Ebivit; Oleovitamin D3; Provitina; Ricketon; Vi-De3; Videkhol; Vigorsan; Vitinc Dan-Dee-3; Colecalciferol. Grades: >98%. CAS No. 67-97-0. Molecular formula: C27H44O. Mole weight: 384.64.
Vitamin K1
Vitamin K1 is a fat-soluble vitamin that occurs widely in green plants, algae, photosynthetic bacteria. Vitamin K1 serves as a precursor to vitamin K2 and is essential for the synthesis of proteins required for blood-clotting, bone metabolism, and cell growth. It is commonly used in dietary supplement for the treatment of bleeding disorders. Vitamin supplement in health care products. Uses: Ingredient of health care products. Synonyms: Phytonadione; Phytomenadione; Phylloquinone; 3-Phytylmenadione; E-Phytonadione; 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl]-1,4-naphthalenedione; Konakion; Mephyton; Phytylmenadione; Phytylmenaquinone; Synthex P; Veda K1; Veta K1; trans-Phylloquinone; α-Phylloquinone; 2',3'-trans-Vitamin K1; [R-[R*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione; Antihemorrhagic Vitamin; Haemokion; Kativ N; Kaywan; Kenadion; Kephton; Kinadion; Konakion; Mono-Kay; Monodion; NSC 270681; Orakay; Pediatrico; Phylloquinone K1; Reconval. Grades: 97.0-103.0%. CAS No. 84-80-0. Molecular formula: C31H46O2. Mole weight: 450.71.
VKGILS-NH2 acetate
VKGILS-NH2 acetate is a reversed control peptide for SLIGKV-NH2, which is a protease-activated receptor 2 (PAR2) agonist. Synonyms: H-Val-Lys-Gly-Ile-Leu-Ser-NH2.CH3CO2H; L-valyl-L-lysyl-glycyl-L-isoleucyl-L-leucyl-L-serinamide acetic acid. Grades: ≥95%. CAS No. 2763585-10-8. Molecular formula: C28H54N8O7.C2H4O2. Mole weight: 674.83.
Volkensin
Volkensin is an insect antifeedant isolated from the leaves of the East African tree Melia volkensii. Grades: >98%. CAS No. 91933-11-8.
Voriconazole Impurity 10 (UK-115191)
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Molecular formula: C10H7F2N3O. Mole weight: 223.18.
Voriconazole Impurity 2
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Molecular formula: C6H4Br2ClFN2. Mole weight: 318.37.
Voriconazole Impurity 3
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine; 4-chloro-5-fluoro-6-(1-bromoethyl)-pyrimidine. Grades: > 98 %. CAS No. 188416-28-6. Molecular formula: C6H5BrClFN2. Mole weight: 239.47.
Voriconazole Impurity 4
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Molecular formula: C16H13ClF3N5O. HCl. Mole weight: 420.22.
Voriconazole Impurity 5
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Molecular formula: C16H13ClF3N5O. HCl. Mole weight: 420.22.
Voriconazole Impurity 6
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: rel-(αR,βR)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol. CAS No. 137330-52-0. Molecular formula: C16H14F3N5O. Mole weight: 349.32.
Voriconazole Impurity 7
Voriconazole Impurity 7 is an impurity of Voriconazole, which is an antifungal medication used to treat a number of fungal infections. Synonyms: 4-Pyrimidineethanol, α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-, (αS,βS)-; (αS,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; (2S,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol. Grades: ≥95%. CAS No. 239807-04-6. Molecular formula: C16H14F3N5O. Mole weight: 349.32.
Voriconazole Impurity 9 (UK-51060)
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Molecular formula: C10H7F2N3O. Mole weight: 223.18.
Voriconazole Impurity B
Cas No. 182369-73-9.
Voriconazole Impurity C
Cas No. 137234-88-9.
Voriconazole Impurity E
Cas No. 5872-8-2.
Voriconazole N-oxide
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-1-oxide-4-pyrimidineethanol; UK 121265. CAS No. 618109-05-0. Molecular formula: C16H14F3N5O2. Mole weight: 365.32.
Voriconazole Related Compound A
One of the impurities of Voriconazole, which has been found to be an ergosterol biosynthesis inhibitor and could be used as an antifungal agent. Synonyms: (2RS,3RS)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol. CAS No. 182230-43-9. Molecular formula: C16H14F3N5O. Mole weight: 349.32.
Voriconazole Related Compound B
Cas No. 137234-63-0.
VX-150
VX-150 is a NaV1.8 blocker that is currently in phase II clinical trial for the treatment of patients with acute pain. Study shows that VX-150 significantly alleviates postoperative pain. Synonyms: Benzamide, N-[1,2-dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)-; N-[1,2-Dihydro-2-oxo-1-[(phosphonooxy)methyl]-4-pyridinyl]-2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamide; VX 150; VX150; (4-(2-(4-Fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzamido)-2-oxopyridin-1(2H)-yl)methyl dihydrogen phosphate. Grades: ≥95%. CAS No. 1793080-72-4. Molecular formula: C21H17F4N2O7P. Mole weight: 516.33.
WKYMVM 2TFA
WKYMVM 2TFA is a selective agonist of the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM), and FPR3 (EC50 = 3 nM) and is expressed on immune cells. It induces Ca2+ mobilization and superoxide production, as well as chemotactic migration of monocytes and neutrophils. Synonyms: H-Trp-Lys-Tyr-Met-Val-D-Met-NH2.2TFA; L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide trifluoroacetic acid; (2R,5S,8S,11S,14S,17S)-17-Amino-14-(4-aminobutyl)-11-(4-hydroxybenzyl)-18-(1H-indol-3-yl)-5-isopropyl-2,8-bis[2-(methylsulfanyl)ethyl]-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-amide trifluoroacetate; W-Peptide TFA salt; WKYMVm TFA salt. Grades: ≥95%. Molecular formula: C41H61N9O7S2.2C2HF3O2. Mole weight: 1084.16.
Wortmannin
It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Synonyms: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 98%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43.
Wrightiin
Wrightiin is a new chlorinated depside from Erioderma wrightii Tuck (?Ascolichenes). CAS No. 107783-44-8. Molecular formula: C18H17ClO7. Mole weight: 380.78.
WRW4 TFA
WRW4 TFA is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling. WRW4 inhibits WKYMVm binding to FPR2 (IC50 = 0.23 μM) and blocks intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. Synonyms: H-Trp-Arg-Trp-Trp-Trp-Trp-NH2.TFA; L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl-L-tryptophanamide trifluoroacetic acid; WRW4 Trifluoroacetate; WRW4 (trifluoroacetate salt). Grades: ≥95%. Molecular formula: C63H66F3N15O8. Mole weight: 1218.29.
X-206
X-206 is an ionophore antibiotic produced by Streptomyces sp. X 206. It acts as a potent and selective inhibitor of SARS-CoV-2. Synonyms: Antibiotic X-206. CAS No. 36505-48-3. Molecular formula: C47H82O14. Mole weight: 871.1.
Xenin 8 acetate
Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM). Molecular formula: C53H83N15O11. Mole weight: 1106.32.
XR651 is a naphthacene-5,12-dione produced by Amycolatopsis X 16735. Synonyms: XR-651; XR 651. CAS No. 189697-45-8. Molecular formula: C21H16O5. Mole weight: 348.3.
Y27632 hydrochloride
Cas No. 129830-38-2.
Z-Ala-Pro-Phe-chloromethylketone
Z-Ala-Pro-Phe-chloromethylketone is an inhibitor of the Ca2+- regulated nuclear scaffold proteinase (CRNSP). Synonyms: Z-APF-CMK; N-benzyloxycarbonyl-Ala-Pro-Phe-chloromethyl ketone. Grades: >98%. CAS No. 217658-18-9. Molecular formula: C26H30ClN3O5. Mole weight: 499.99.
Z-D-Arg-Gly-Arg-pNA 2HCl is a chromogenic substrate for determining factor Xa. Synonyms: L-Argininamide, N2-[(Phenylmethoxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-, Dihydrochloride; N2-[(Benzyloxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-L-argininamide hydrochloride (1:2); Z-RGR-pNA; Benzyl-D-Arg-Gly-Arg-pNA dihydrochloride; Benzyl-D-Arg-Gly-Arg-p-nitroanilide dihydrochloride; Factor Xa Chromogenic Substrate dihydrochloride; S-2765 dihydrochloride. Grades: 95%. CAS No. 113711-77-6. Molecular formula: C28H39N11O7.2HCl. Mole weight: 714.61.
(Z)-Desbutyl Lumefantrine
(Z)-Desbutyl Lumefantrine is a metabolite of Lumefantrine. Synonyms: (Z)-Desbutyl-benflumetol; (9Z)-α-[(Butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol. Grades: > 95%. CAS No. 355841-11-1. Molecular formula: C26H24Cl3NO. Mole weight: 472.83.
Zerbaxa (Ceftolozane/tazobactam)
Zerbaxa (Ceftolozane/tazobactam), a combination product consisting of a cephalosporin-class antibacterial drug and a beta-lactamase inhibitor, is a combination antibiotic medication used for the treatment of complicated urinary tract infections and complicated intra-abdominal infections in adults. Synonyms: Ceftolozane-tazobactam mixt.; CXA 201 sulfate-tazobactam mixt.; 1H-Pyrazolium, 5-amino-4-[[[(2-aminoethyl)amino]carbonyl]amino]-2-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-, inner salt, mixt. with (2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide. CAS No. 1613740-46-7. Molecular formula: C23H30N12O8S2.C10H12N4O5S. Mole weight: 966.98.
Zg
Zg is a red quinone piment produced from Streptomyces Thermoviolaceus sub sp. pigens var WR-141. Molecular formula: C22H18O8. Mole weight: 410.4.
Zgg
Zgg is a red quinone piment produced from Streptomyces Thermoviolaceus sub sp. pigens var WR-141. CAS No. 63972-29-2. Molecular formula: C22H16O8. Mole weight: 408.4.
Z-GPR-AMC is a fluorogenic substrate for cathepsin K, granzyme A, and thrombin. Synonyms: Z-Gly-Pro-Arg-AMC HCl; L-Argininamide, N-[(phenylmethoxy)carbonyl]glycyl-L-prolyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-,monohydrochloride(9ci). CAS No. 201928-42-9. Molecular formula: C31H38ClN7O7. Mole weight: 656.13.
Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone
Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone is a cell permeable inhibitor of caspase-8 and granzyme B. The bis-methyl ester of Z-Ile-Glu(OMe)-Thr-DL-Asp(OMe)-fluoromethylketone blocks CD95-induced apoptosis. Synonyms: Z-IETD-FMK; Z-IE(OMe)TD(OMe)-FMK; Methyl (5S,8S,11S)-5-[(2S)-2-butanyl]-14-(fluoroacetyl)-11-[(1R)-1-hydroxyethyl]-8-(3-methoxy-3-oxopropyl)-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazahexadecan-16-oate. Grades: ≥95%. CAS No. 1926163-59-8. Molecular formula: C30H43FN4O11. Mole weight: 654.69.
ZIP acetate is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1-2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH.CH3CO2H; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine acetic acid; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine acetate; Peptide ZIP acetate; z-Pseudosubstrate inhibitory peptide acetate. Grades: ≥94%. Molecular formula: C92H158N30O19. Mole weight: 1988.43.
ZIP (Scrambled) acetate
ZIP (Scrambled) TFA, a scrambled peptide, can be used as a negative control for zeta inhibitory peptide (ZIP). Synonyms: myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH.CH3CO2H; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine acetic acid. Grades: ≥95%. CAS No. 2763584-14-9. Molecular formula: C92H158N30O19. Mole weight: 1988.43.
Z-Leu-Leu-Tyr-α-keto aldehyde, an excellent inhibitor of serine and cysteine proteases, is an excellent inhibitor of chymotryptic-like activity of the proteasome with a Ki of about 3.0 nM. It may be valuable in identifying the role of the proteasome in the normal and abnormal pathways of protein catabolism in cells. Synonyms: L-Leucinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-[(4-hydroxyphenyl)methyl]-2,3-dioxopropyl]-; Z-LLY-α-keto aldehyde; N-[(Benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-(4-hydroxyphenyl)-3,4-dioxo-2-butanyl]-L-leucinamide; benzyl ((S)-1-(((S)-1-(((S)-1-(4-hydroxyphenyl)-3,4-dioxobutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate; Cbz-Leu-Leu-Tyr-α-keto aldehyde. Grades: ≥95%. CAS No. 204649-66-1. Molecular formula: C30H39N3O7. Mole weight: 553.66.
Z-Leu-Tyr-chloromethylketone
Z-Leu-Tyr-chloromethylketone is an E.coli ClpP inhibitor. Synonyms: Carbobenzyloxyleucyl-tyrosine chloromethyl ketone; Z-LY-CMK; 2-{[ (Benzyloxy) (hydroxy)methylidene]amino}-N-[4-chloro-1- (4-hydroxyphenyl)-3-oxobutan-2-yl]-4-methylpentanimidic acid. CAS No. 56979-35-2. Molecular formula: C24H29ClN2O5. Mole weight: 460.95.
Z-LVG-CHN2
Z-LVG-CHN2 is a tripeptide derivative that mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50 = 190 nM) via inhibition of SARS-COV-2 3CL pro protease. Synonyms: L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-leucyl-N-(3-diazo-2-oxopropyl)-(9CI); Z-LVG-DMK. Grades: 95%. CAS No. 119670-30-3. Molecular formula: C22H31N5O5. Mole weight: 445.51.
Z-Lys-Arg-pNA 2HCl
Cas No. 201847-59-8. Molecular formula: C26H38Cl2N8O6. Mole weight: 629.54.
An impurity of Mycophenolic which inhibits an enzyme needed for the growth of T cells and B cells. Synonyms: (4Z)-6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic Acid. Grades: > 95%. CAS No. 483-60-3. Molecular formula: C17H20O6. Mole weight: 320.35.
Z-Phe-Arg-pNA hydrochloride
Z-Phe-Arg-pNA is a sensitive chromogenic substrate for cathepsin L and papain. Grades: >99%. CAS No. 59188-54-4. Molecular formula: C29H34ClN7O6. Mole weight: 612.08.
Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone
Z-Phe-Lys-2,4,6-trimethylbenzoyloxy-methylketone is a very effective in vivo cathepsin B inhibitor in rats. Synonyms: 2,4,6-Trimethylbenzoic acid Z-L-Phe-L-Lys-methyl ester; Z-FK-ck. Grades: 95%. CAS No. 118253-05-7. Molecular formula: C34H41N3O6. Mole weight: 587.70.
Z-Phe-Phe-diazomethylketone
Z-FF-DMK is a cathepsin L-selective inhibitor. Synonyms: (Z-L-Phe-L-Phe-)Diazomethane; Benzyl oxycarbonyl phenyl alanyl phenyl alanine diazomethyl ketone. Grades: >98%. CAS No. 65178-14-5. Molecular formula: C27H26N4O4. Mole weight: 470.53.