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Streptolydigin
Streptolydigin is a nitrogen-containing and oxygen-containing heterocyclic antibiotic produced by Str. lydicus NRRL 2433. It has anti-gram-positive bacteria and mycobacterial activity. Synonyms: Antibiotic D-45; Portamycin. Grades: >98%. CAS No. 7229-50-7. Molecular formula: C32H44N2O9. Mole weight: 600.70.
Streptovaricin U
Streptovaricin U is an acyclic ansamycin produced by Str. spectabilis. CAS No. 74200-47-8. Molecular formula: C36H49NO10. Mole weight: 655.77.
Stresscopin (3-40) (human)
Stresscopin (3-40) (human), a highly selective ligand of the CRF-II receptor, inhibits food intake, delays gastric emptying and reduces heat-induced edema in mammals. Synonyms: Urocortin III (human); H-Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2; L-phenylalanyl-L-threonyl-L-leucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-threonyl-L-asparagyl-L-isoleucyl-L-methionyl-L-asparagyl-L-leucyl-L-leucyl-L-phenylalanyl-L-asparagyl-L-isoleucyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-asparagyl-L-leucyl-L-arginyl-L-alanyl-L-glutaminyl-L-alanyl-L-alanyl-L-alanyl-L-asparagyl-L-alanyl-L-histidyl-L-leucyl-L-methionyl-L-alanyl-L-glutaminyl-L-isoleucinamide; Urocortin-3 (human). Grades: ≥90%. CAS No. 357952-09-1. Molecular formula: C185H307N53O50S2. Mole weight: 4137.93.
Stresscopin (human)
Stresscopin is a specific endogenous ligand of the corticotropin-releasing hormone receptor type 2 (CRHR2) that maintains homeostasis after stress. Intraperitoneal injection of stresscopin can inhibit the formation of heat induced edema in anesthetized rats. It also reduces food intake and inhibits gastric emptying activity. Synonyms: SCP (human); H-Thr-Lys-Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2. Grades: ≥95% by HPLC. CAS No. 352020-03-2. Molecular formula: C195H326N56O53S2. Mole weight: 4367.15.
Strobilurin A
Strobilurin A is a compound produced by Strobilurus tenacellus No. 21602. It has the effect of anti-filamentous fungi and yeast, but not against bacteria. It can inhibit the synthesis of protein, RNA and DNA. Synonyms: Mucidin. CAS No. 52110-55-1. Molecular formula: C16H18O3. Mole weight: 258.31.
Strobilurin B
Strobilurin B is a compound produced by Strobilurus tenacellus No. 21602. It has the effect of anti-filamentous fungi and yeast, but not against bacteria. It can inhibit the synthesis of protein, RNA and DNA. CAS No. 65105-52-4. Molecular formula: C17H19ClO4. Mole weight: 322.78.
Strobilurin C
Strobilurin C is a compound produced by Xerula longipes. It has antifungal and protein inhibitory effects. Synonyms: 3,5-Hexadienoic acid, 2-(methoxymethylene)-3-methyl-6-(3-((3-methyl-2-butenyl)oxy)phenyl)-, methyl ester, (E,E,E)-. CAS No. 87081-57-0. Molecular formula: C21H26O4. Mole weight: 342.43.
Strobilurin G
Strobilurin G is an antibiotic produced by Bolina lutea Sacc. It has strong anti-fungal activity, and its in vitro anti-tumor proliferation IC50 is 0.01 μmol/L. Synonyms: 6-(3,4-DIHYDRO-4,4-DIMETHYL-3-((3-METHYL-2-BUTENYL)OXY)-2H-1,5-BENZODIOXEPIN-7-YL)-2-(METHOXYMETHYLENE)-3-METHYL-, 3,5-HEXADIENOIC ACID METHYL ESTER; STROBILURIN G; 6-(3,4-dihydro-4,4-dimethyl-3-((3-methyl-2-butenyl)oxy)-2H-1,5-benzodioxepin-7-yl)-2-(metho. CAS No. 129145-64-8. Molecular formula: C26H34O6. Mole weight: 442.54.
Strychnospermine
Strychnospermine is an alkaloid that has been found in Strychnos psilosperma. Synonyms: (19R)-1-Acetyl-17,19-epoxy-11-methoxycuran; 1-[(4bR,7S,7aS,8aR,9S,10R,12aR,12bS)-5,6,8,8a,9,10,12a,12b-octahydro-2-methoxy-10-methyl-7aH-7,9-methanopyrano[3,4-a]pyrrolo[2,3-d]carbazol-13(12H)-yl]-ethanone; 1-[(2S,16α,19β,20α)-11-Methoxy-19-methyl-16,17-dihydro-2,16-cycloformosanan-1-yl]ethanone; Ethanone, 1-[(19R)-17,19-epoxy-11-methoxycuran-1-yl]-; 1-((7aS,8aR,9S,10R,12aR,12bS)-2-methoxy-10-methyl-5,6,7a,8,8a,9,12a,12b-octahydro-10H-7,9-methanopyrano[3,4-a]pyrrolo[2,3-d]carbazol-13(12H)-yl)ethan-1-one. Grades: >95% by HPLC. CAS No. 509-45-5. Molecular formula: C22H28N2O3. Mole weight: 368.47.
Subconfluentic acid
Subconfluentic acid is a depside metabolite from the lichen Haematomma pachycarpum. Synonyms: 4-Carboxy-3-methoxy-5-pentylphenyl 2-hydroxy-4-methoxy-6-(2-oxopentyl)benzoate. CAS No. 108548-74-9. Molecular formula: C26H32O8. Mole weight: 472.53.
Subdidymic acid
Subdidymic acid is biosynthesized in the North American lichen Cladonia leporina, a representative of the Cladoniaceae. Synonyms: 2-Dibenzofurancarboxylic acid, 3-hydroxy-7-methoxy-1,9-dipropyl-; 3-hydroxy-7-methoxy-1,9-dipropyldibenzo[b,d]furan-2-carboxylic acid. CAS No. 86820-01-1. Molecular formula: C20H22O5. Mole weight: 342.39.
Subdivaricatic acid
Subdivaricatic acid is a compound from Ramalina americana. CAS No. 132396-93-1. Molecular formula: C19H20O7. Mole weight: 360.36.
Sublobaric acid
Sublobaric acid is isolated from the lichen Anzia hypoleucoides. Synonyms: 8-Hydroxy-3-methoxy-11-oxo-1-(1-oxopropyl)-6-pentyl-11H-dibenzo[b,e][1,4]dioxepin-7-carboxylic acid; 11H-Dibenzo[b,e][1,4]dioxepin-7-carboxylic acid, 8-hydroxy-3-methoxy-11-oxo-1-(1-oxopropyl)-6-pentyl-. CAS No. 197009-25-9. Molecular formula: C23H24O8. Mole weight: 428.43.
Submerochlorophaeic acid
Submerochlorophaeic acid is a substance from the Cladonia chlorophaea. CAS No. 103538-07-4. Molecular formula: C22H26O8. Mole weight: 418.44.
Subpaludosic acid
Cas No. 103538-08-5. Molecular formula: C21H24O8. Mole weight: 404.41.
Subsphaeric acid is a depside from dimelaena lichens. CAS No. 120091-90-9. Molecular formula: C21H24O7. Mole weight: 388.41.
Substance P (1-7) 2TFA
Substance P (1-7) 2TFA is the main bioactive metabolite formed after the proteolytic degradation of tachykinin substance P (SP), which has anti-inflammatory, anti-nociceptive, and anti-hyperalgesic effects. Synonyms: H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH.2TFA; L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanine trifluoroacetic acid; 1-7-Substance P, 2,2,2-trifluoroacetate (1:2). Grades: ≥95%. Molecular formula: C41H65N13O10.2C2HF3O2. Mole weight: 1128.08.
Substance P (1-9)
Substance P(1-9) is a fragment of Subtance P, which decreases the inactivation of substance P by the guinea-pig ileum and urinary bladder. Synonyms: H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-OH; ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY; substance P fragment 1-9. CAS No. 57468-17-4. Molecular formula: C52H77N15O12. Mole weight: 1104.26.
Substance P (7-11)
Substance P fragment. Increases PGE2 and collagenase production. Involved in pain signal transmission. Anti-inflammatory and immunomodulatory agent. Active in vitro and in vivo. Synonyms: H-Phe-Phe-Gly-Leu-Met-NH2; SP(7-11); Phe1-Phe2-Gly3-Leu4-Met5-NH2. Grades: >95%. CAS No. 51165-05-0. Molecular formula: C31H44N6O5S. Mole weight: 612.78.
SUC-ALA-ALA-ALA-AMC
A sensitive fluorogenic substrate for pancreatic elastase. Synonyms: Suc-Ala-Ala-Ala-7-Amino-4-Methylcoumarin; succinyl-Ala-Ala-Ala-4-methylcoumaryl-7-amide; 4-((S)-1-((S)-1-((S)-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylamino)-4-oxobutanoic acid. CAS No. 73617-90-0. Molecular formula: C23H28N4O8. Mole weight: 488.49.
Suc-Ala-Ala-Pro-Abu-pNA
Suc-Ala-Ala-Pro-Abu-pNA is a colorimetric substrate for pancreatic elastase. Synonyms: Elastase Substrate IV, Colorimetric; Suc-AAP-Abu-pNA; N-(3-Carboxypropanoyl)-L-alanyl-L-alanyl-N-{(2S)-1-[(4-nitrophenyl)amino]-1-oxo-2-butanyl}-L-prolinamide. Grades: ≥95%. CAS No. 108392-27-4. Molecular formula: C25H34N6O9. Mole weight: 562.57.
Suc-Ala-Ala-Pro-Met-pNA
Suc-Ala-Ala-Pro-Met-pNA is a sensitive substrate for human pancreatic elastase. Synonyms: succinyl-Ala-Ala-Pro-Met-p-nitroanilide. CAS No. 72682-73-6. Molecular formula: C26H36N6O9S. Mole weight: 608.66.
Suc-Ala-Phe-Pro-Phe-pNA
Suc-Ala-Phe-Pro-Phe-pNA is a substrate for FK-506 binding proteins and cyclophilins, which belong to the group of peptidyl prolyl cis-trans isomerases (PPIases). Synonyms: Suc-apppa; Succinimidyl-alanyl-phenylalanyl-prolyl-phenylalanine 4-nitroanilide. Grades: >99%. CAS No. 128802-73-3. Molecular formula: C36H40N6O9. Mole weight: 700.75.
Suc-Ala-Pro-Ala-AMC
A sensitive substrate for human neutrophil elastase. Synonyms: succinyl-Ala-Pro-Ala-MCA; 4-((S)-1-((S)-2-((S)-1-(4-methyl-2-oxo-2H-chromen-7-ylamino)-1-oxopropan-2-ylcarbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-ylamino)-4-oxobutanoic acid. CAS No. 88467-44-1. Molecular formula: C25H30N4O8. Mole weight: 514.53.
Suc-Ala-Pro-pNA
Suc-Ala-Pro-pNA is the chromogenic substrate for prolyl endopeptidase. Synonyms: Suc-AP-pNA; succinyl-alanyl-proline-p-nitro-anilide; L-Prolinamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-N-(4-nitrophenyl)-; N-(3-Carboxypropanoyl)-L-alanyl-N-(4-nitrophenyl)-L-prolinamide; 4-(((S)-1-((S)-2-((4-nitrophenyl)carbamoyl)pyrrolidin-1-yl)-1-oxopropan-2-yl)amino)-4-oxobutanoic acid. Grades: ≥95%. CAS No. 95632-46-5. Molecular formula: C18H22N4O7. Mole weight: 406.39.
Suc-e8-(Aop)-PLGC(Me)AG-r9-c-NH2, an activated cell-penetrating peptide linked to nanoparticles, acts as a dual probe for in vivo fluorescence and MR imaging of proteases.
Suc-Leu-Leu-Val-Tyr-pNA
Suc-Leu-Leu-Val-Tyr-pNA is a chromogenic substrate analogue to the proteasome substrate Suc-LLVY-AMC. Synonyms: Suc-LLVY-pNA; N-(3-Carboxypropanoyl)-L-leucyl-L-leucyl-L-valyl-N-(4-nitrophenyl)-L-tyrosinamide; L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-nitrophenyl)-. Grades: ≥90%. CAS No. 1926163-44-1. Molecular formula: C36H50N6O10. Mole weight: 726.83.
Suc-Phe-Leu-Phe-4MbNA
Suc-Phe-Leu-Phe-4MbNA is a substrate for chymotrypsin and Lon proteases as E.coli protease La. Synonyms: Suc-FLF-MNA; succinyl-Phe-Leu-Phe-MNA. CAS No. 201982-89-0. Molecular formula: C39H44N4O7. Mole weight: 680.79.
Suc-Phe-Leu-Phe-SBzl
Suc-Phe-Leu-Phe-SBzl is a very sensitive substrate for the determination of cathepsin G activity. Synonyms: N-Succinyl-Phe-Leu thiobenzyl ester; succinyl-Phe-Leu-Phe-thiobenzyl ester; (4S,7S,10S)-4,10-dibenzyl-7-isobutyl-3,6,9,12-tetraoxo-1-phenyl-2-thia-5,8,11-triazapentadecan-15-oic acid. CAS No. 80651-94-1. Molecular formula: C35H41N3O6S. Mole weight: 631.78.
Sulfamethazine is a sulfonamide antibacterial agent that competitively inhibits dihydrospteric acid synthase, blocks the synthesis of folic acid and inhibits growth and proliferation. It can be used to treat pasteurosis, mastitis, urinary tract infections caused by sensitive bacteria in livestock, and can also be used for swine atrophic rhinitis, streptococcal disease, swine toxoplasmosis and coccidiosis. Uses: Anti-infective agents. Synonyms: HSDB 4157; HSDB-4157; HSDB4157; Sulfadimidine; Intradine; Kelametazine; 4-Amino-N-(4,6-Dimethyl-2-pyrimidinyl)benzenesulfonamide; Azolmetazin; Diazil. Grades: >98%. CAS No. 57-68-1. Molecular formula: C12H14N4O2S. Mole weight: 278.33.
Sulfazecin
Sulfazecin is a water-soluble acidic substance produced by Pseudomonas acidophila G 6302. It has anti-Gram-negative bacteria activity and weak anti-Gram-positive bacteria activity. Grades: >98%. CAS No. 77912-79-9. Molecular formula: C12H20N4O9S. Mole weight: 396.38.
Sulfo-N-succinimidyl 4-maleimidobutyrate sodium salt
Sulfo-N-succinimidyl 4-maleimidobutyrate, a water-soluble and heterobifunctional cross-linking reagent, is used to conjugate cysteine-containing peptides to carrier proteins or surfaces. Synonyms: Sulfo-GMBS sodium salt; Sodium 1-((4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate; 1-[4-(N-Maleimideyl)butyryloxy]-2,5-dioxopyrrolidine-3-sulfonic acid sodium salt; 3-Pyrrolidinesulfonic acid, 1-[4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxobutoxy]-2,5-dioxo-, sodium salt (1:1). Grades: ≥90%. CAS No. 185332-92-7. Molecular formula: C12H11N2NaO9S. Mole weight: 382.28.
Sulfurmycin D
Sulfurmycin D is an anthracycline antibiotic produced by Str. galilaeus OBB-111. It has anti-Gram-positive bacteria and anti-tumor activity. Synonyms: 1-Naphthacenecarboxylic acid, 1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-2-(2-oxopropyl)-4-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl)oxy)-, methyl ester, (1R-(1alpha,2beta,4beta))-. Grades: 95%. CAS No. 83753-74-6. Molecular formula: C31H35NO11. Mole weight: 597.61.
Supaglutide
Supaglutide is a glucagon-like peptide-1 (GLP-1) analog developed for the treatment of type 2 diabetes mellitus (T2DM). Supaglutide was shown to regulate blood glucose and lipid homeostasis in diabetic rhesus monkeys. Synonyms: YN011-301.
Superconfluentic acid
Superconfluentic acid is a depside metabolite of the lichen. CAS No. 108529-22-2. Molecular formula: C32H44O8. Mole weight: 556.69.
Superplanaic acid
Superplanaic acid is a depside obtained from the lichen lecanora planaica. CAS No. 156372-09-7. Molecular formula: C31H44O7. Mole weight: 528.68.
SV40 T-Ag-derived NLS peptide acetate
SV40 T-Ag-derived NLS peptide, derived from the Large T antigen residues 47 to 56, is the nuclear localization signal DNA tagged to this peptide, which is effectively translocated into the nucleus. Molecular formula: C68H115N19O20S. Mole weight: 1550.82.
Syntide 2 acetate
Syntide-2 acetate, a synthetic peptide, is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) (Ki = 12 μM) and protein kinase C (Km = 11 μM). Synonyms: H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH.CH3CO2H; L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanyl-glycyl-L-leucyl-L-prolyl-glycyl-L-lysyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C70H126N20O20. Mole weight: 1567.85.
T Acetic acid
A nucleobase for PNA synthesis. Synonyms: Thymine-1-acetic acid; 2-(5-Methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetic acid; (5-Methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)acetic acid. Grades: 98%. CAS No. 20924-05-4. Molecular formula: C7H8N2O4. Mole weight: 184.15.
Tacrolimus EP Impurity C is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 12, 18-trimethyl-8-(prop-2-en-1-yl)-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; 10-Desmethyl tacrolimus; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 12, 18-trimethyl-8-(2-propen-1-yl)-, (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; Tacrolimus monohydrate EP impurity C; (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Allyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14, 16-dimethoxy-4, 12, 18-trimethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21-(4H, 23H)-tetrone; Desmethyl tacrolimus. Grades: ≥95%. Molecular formula: C43H67NO12. Mole weight: 789.99.
Tacrolimus EP Impurity D
Tacrolimus EP Impurity D is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8S, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(prop-2-en-1-yl)-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; 8-epi Tacrolimus; 8-Epitacrolimus; Tacrolimus anhydrous 8-epimer; Tacrolimus 8-epimer [USP-RS]; Tacrolimus monohydrate impurity D [EP]; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5R*, 8R*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-; (-)-8-epi-Tacrolimus; (3S, 4R, 5S, 8S, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-8-Allyl-5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-{(E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl}-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-15, 19-epoxy-3H-pyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(4H, 23H)-tetrone. Grades: ≥90% by HPLC. CAS No. 129212-35-7. Molecular formula: C44H69NO12. Mole weight: 804.04.
Tacrolimus EP Impurity E
Tacrolimus EP Impurity E is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-5, 19-dihydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-3, 4, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-octadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; Dihydro Tacrolimus; Dihydro-FK 506; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-propyl-, (3S, 4R, 5S, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5, 6, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-5, 19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-. Grades: ≥90% by HPLC. CAS No. 104987-30-6. Molecular formula: C44H71NO12. Mole weight: 806.06.
Tacrolimus EP Impurity G
Cas No. 144490-63-1.
Tacrolimus EP Impurity H
Tacrolimus EP Impurity H is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (1E,3S,4R,5S,8R,9E,12S,14S)-5-hydroxy-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-14-methoxy-14-[(2R,3S,5R)-3-methoxy-5-methyl-6-oxooxan-2-yl]-2,4,10,12-tetramethyl-7-oxo-8-(prop-2-en-1-yl)tetradeca-1,9-dien-3-yl (2S)-1-formylpiperidine-2-carboxylate; Tacrolimus monohydrate impurity H [EP]; 2-Piperidinecarboxylic acid, 1-formyl-, (1S,2R,3S,6R,7E,10S,12S)-3-hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propen-1-yl)-12-[(2R,3S,5R)-tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl]-7-dodecen-1-yl ester, (2S)-; (1S,2R,3S,6R,7E,10S,12S)-3-Hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trimethyl-5-oxo-6-(2-propen-1-yl)-12-[(2R,3S,5R)-tetrahydro-3-methoxy-5-methyl-6-oxo-2H-pyran-2-yl]-7-dodecen-1-yl (2S)-1-formyl-2-piperidinecarboxylate; 2-Piperidinecarboxylic acid, 1-formyl-, (1S,2R,3S,6R,7E,10S,12S)-3-hydroxy-1-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-12-methoxy-2,8,10-trim. Grades: ≥95%. CAS No. 143210-33-7. Molecular formula: C43H69NO11. Mole weight: 776.01.
Tacrolimus EP Impurity I
Tacrolimus EP Impurity I is an impurity of Tacrolimus, which is a calcineurin inhibitor used as an immunosuppressant after organ transplantation to reduce the activity of the patient's immune system, thereby reducing the risk of organ rejection. Synonyms: (3S, 4R, 5E, 8R, 9E, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-19-hydroxy-3-[(1E)-1-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(prop-2-en-1-yl)-3, 4, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-hexadecahydro-7H-15, 19-epoxypyrido[2, 1-c][1, 4]oxaazacyclotricosine-1, 7, 20, 21(23H)-tetrone; Tacrolimus diene; 23,24-Anhydro Tacrolimus; Δ23-FK-506; Tacrolimus Impurity I; Tacrolimus monohydrate impurity I [EP]; 15,19-Epoxy(5E,9E)-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-tetradecahydro-19-hydroxy-3-[(1E)-2-[(1R, 3R, 4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propen-1-yl)-, (3S, 4R, 8R, 12S, 14S, 15R, 16S, 18R, 19R, 26aS)-; 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8, 11, 12, 13, 14, 15, 16, 17, 18, 19, 24, 25, 26, 26a-tetradecahydro-19-hydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14, 16-dimethoxy-4, 10, 12, 18-tetramethyl-8-(2-propenyl)-, [3S-[3R*[E(1S*, 3S*, 4S*)], 4S*, 5E, 8S*, 9E, 12R*, 14R*, 15S*, 16R*, 18S*, 19S*, 26aR*]]-. Grades: ≥90% by HPLC. CAS No. 104987-16-8. Molecular formula: C44H67NO11. Mole weight: 786.02.
Tafluprost ethyl ester is an analog of prostaglandin F2α (PGF2α), which has been approved for the treatment of glaucoma. Synonyms: AFP 175; Ethyl (Z)-7-[(1R,2R,3R,5S)-2-[(E)-3,3-difluoro-4-phenoxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoate. Grades: ≥98%. CAS No. 209860-89-9. Molecular formula: C24H32F2O5. Mole weight: 438.5.
TAT-GluA2 3Y acetate
TAT-GluA2 3Y acetate is a cell-penetrating peptide containing tyrosine residues. It inhibits the phosphorylation of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor endocytosis. Synonyms: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Tyr-Lys-Glu-Gly-Tyr-Asn-Val-Tyr-Gly-OH.CH3CO2H; L-tyrosyl-glycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-tyrosyl-L-lysyl-L-alpha-glutamyl-glycyl-L-tyrosyl-L-asparagyl-L-valyl-L-tyrosyl-glycine acetic acid. Grades: ≥95%. Molecular formula: C117H189N43O31. Mole weight: 2694.07.
Tau Peptide (1-16) (human)
Tau peptide (1-16) (human) corresponds to the N-terminus of the nascent Tau protein. Posttranslational modifications include removal of N-terminal Met and acetylation of Ala2. Synonyms: H-Met-Ala-Glu-Pro-Arg-Gln-Glu-Phe-Glu-Val-Met-Glu-Asp-Met-Ala-Gly-OH. Grades: ≥95%. CAS No. 2022956-53-0. Molecular formula: C77H120N20O28S3. Mole weight: 1870.12.
Tau Peptide (244-274) (Repeat 1 Domain)
During heparin-induced self-aggregation of the four repeat domain peptides (R1-R4) excised from tau, R1, which is similar to the Tau peptide (244-274), shows the strongest resistance to filament formation. Its conformation remains the same. It maintains the same random structure under acidic and neutral conditions. Synonyms: H-Gln-Thr-Ala-Pro-Val-Pro-Met-Pro-Asp-Leu-Lys-Asn-Val-Lys-Ser-Lys-Ile-Gly-Ser-Thr-Glu-Asn-Leu-Lys-His-Gln-Pro-Gly-Gly-Gly-Lys-OH; L-Glutaminyl-L-threonyl-L-alanyl-L-prolyl-L-valyl-L-prolyl-L-methionyl-L-prolyl-L-alpha-aspartyl-L-leucyl-L-lysyl-L-asparaginyl-L-valyl-L-lysyl-L-seryl-L-lysyl-L-isoleucylglycyl-L-seryl-L-threonyl-L-alpha-glutamyl-L-asparaginyl-L-leucyl-L-lysyl-L-histidyl-L-glutaminyl-L-prolylglycylglycylglycyl-L-lysine. Grades: ≥95%. CAS No. 330456-24-1. Molecular formula: C141H238N42O44S. Mole weight: 3257.63.
Tau Peptide (273-284), a Tau fragment containing the PHF6 region, plays a central role in Tau aggregation. Synonyms: H-Gly-Lys-Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-OH; glycyl-L-lysyl-L-valyl-L-glutaminyl-L-isoleucyl-L-isoleucyl-L-asparagyl-L-lysyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-leucine. Grades: ≥95%. CAS No. 1663490-91-2. Molecular formula: C62H113N17O17. Mole weight: 1368.68.
Tau 294-305, an anti-tau vaccine, conjugates to KLH via an N-terminal cysteine. Tau Peptide (294-305) (human) may prevent the formation of beta/beta-helix structure of protofilaments, including residues 306-378. Synonyms: Microtubule-Associated Protein Tau (610-621) (human); H-Lys-Asp-Asn-Ile-Lys-His-Val-Pro-Gly-Gly-Gly-Ser-OH; L-Lysyl-L-α-aspartyl-L-asparaginyl-L-isoleucyl-L-lysyl-L-histidyl-L-valyl-L-prolylglycylglycylglycyl-L-serine. Grades: ≥95%. CAS No. 1428135-29-8. Molecular formula: C51H85N17O17. Mole weight: 1208.32.
Tau Peptide (306-336) (Repeat 3 Domain)
Tau Peptide (306-336) (Repeat 3 Domain), the amphipathic helical structure of the third fragment (306-336) of the four-repeat microtubule-binding domain of water-soluble Tau protein, may be involved in the formation of neuropathological filament. Synonyms: H-Val-Gln-Ile-Val-Tyr-Lys-Pro-Val-Asp-Leu-Ser-Lys-Val-Thr-Ser-Lys-Cys-Gly-Ser-Leu-Gly-Asn-Ile-His-His-Lys-Pro-Gly-Gly-Gly-Gln-OH; L-Glutamine, L-valyl-L-glutaminyl-L-isoleucyl-L-valyl-L-tyrosyl-L-lysyl-L-prolyl-L-valyl-L-α-aspartyl-L-leucyl-L-seryl-L-lysyl-L-valyl-L-threonyl-L-seryl-L-lysyl-L-cysteinylglycyl-L-seryl-L-leucylglycyl-L-asparaginyl-L-isoleucyl-L-histidyl-L-histidyl-L-lysyl-L-prolylglycylglycylglycyl-. Grades: ≥95%. CAS No. 330456-26-3. Molecular formula: C143H236N42O42S. Mole weight: 3247.77.
The non-phosphorylated analogue of Tau fragment 379-408 phosphorylated at Ser396 and Ser404 partially blocks antibody binding to the tau region 396/404. Synonyms: L-Arginyl-L-alpha-glutamyl-L-asparaginyl-L-alanyl-L-lysyl-L-alanyl-L-lysyl-L-threonyl-L-alpha-aspartyl-L-histidylglycyl-L-alanyl-L-alpha-glutamyl-L-isoleucyl-L-valyl-L-tyrosyl-L-lysyl-L-seryl-L-prolyl-L-valyl-L-valyl-L-serylglycyl-L-alpha-aspartyl-L-threonyl-L-seryl-L-prolyl-L-arginyl-L-histidyl-L-leucine; H-Arg-Glu-Asn-Ala-Lys-Ala-Lys-Thr-Asp-His-Gly-Ala-Glu-Ile-Val-Tyr-Lys-Ser-Pro-Val-Val-Ser-Gly-Asp-Thr-Ser-Pro-Arg-His-Leu-OH. Grades: ≥95%. CAS No. 1246357-53-8. Molecular formula: C140H228N44O46. Mole weight: 3263.62.
Tau Peptide (401-411)-Lys-Lys
Tau epitope was used to improve the anti-Tau antibody BR135 directed against the microtubule-binding repeat region. Synonyms: Tau Peptide Isoform F (401-411)-Lys-Lys; H-Gly-Asp-Thr-Ser-Pro-Arg-His-Leu-Ser-Asn-Val-Lys-Lys-OH; Tau Peptide (323-335); Glycyl-L-α-aspartyl-L-threonyl-L-seryl-L-prolyl-L-arginyl-L-histidyl-L-leucyl-L-seryl-L-asparaginyl-L-valyl-L-lysyl-L-lysine. Grades: ≥95%. CAS No. 2022956-59-6. Molecular formula: C60H103N21O20. Mole weight: 1438.61.
Tau Peptide (45-73) (Exon 2/Insert 1 Domain)
Tau Peptide (45-73) (Exon 2/Insert 1 Domain) is Tau's so-called ''projection domain'' sequence. Its phosphorylated residues at sites 68, 69 and 71 have been identified on transformed PHF-Tau (paired helical filament-tau). Synonyms: H-Glu-Ser-Pro-Leu-Gln-Thr-Pro-Thr-Glu-Asp-Gly-Ser-Glu-Glu-Pro-Gly-Ser-Glu-Thr-Ser-Asp-Ala-Lys-Ser-Thr-Pro-Thr-Ala-Glu-OH; L-α-Glutamyl-L-seryl-L-prolyl-L-leucyl-L-glutaminyl-L-threonyl-L-prolyl-L-threonyl-L-α-glutamyl-L-α-aspartylglycyl-L-seryl-L-α-glutamyl-L-α-glutamyl-L-prolylglycyl-L-seryl-L-α-glutamyl-L-threonyl-L-seryl-L-α-aspartyl-L-alanyl-L-lysyl-L-seryl-L-threonyl-L-prolyl-L-threonyl-L-alanyl-L-glutamic acid. Grades: ≥95%. CAS No. 2022956-54-1. Molecular formula: C120H189N31O57. Mole weight: 2977.95.