BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
Iberiotoxin, a toxin extracted from the venom of the scorpion Buthus tamulus, is a selective blocker of high-conductance Ca2+-activated K+ channel. Synonyms: Pyr-Phe-Thr-Asp-Val-Asp-Cys-Ser-Val-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-Gln-OH (Disulfide bridge: Cys7-Cys28, Cys13-Cys33, Cys17-Cys35); 5-Oxo-L-prolyl-L-phenylalanyl-L-threonyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-cysteinyl-L-seryl-L-valyl-L-seryl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-tryptophyl-L-seryl-L-valyl-L-cysteinyl-L-lysyl-L-α-aspartyl-L-leucyl-L-phenylalanylglycyl-L-valyl-L-α-aspartyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-methionylglycyl-L-lysyl-L-lysyl-L-cysteinyl-L-arginyl-L-cysteinyl-L-tyrosyl-L-glutamine cyclic (7?28),(13?33),(17?35)-tris(disulfide); 4-L-aspartic acid-6-L-aspartic acid-8-L-serine-9-L-valine-18-L-lysine-19-L-aspartic acid-21-L-phenylalanine-22-glycine-23-L-valine-24-L-aspartic acid-30-glycine-37-L-glutamine-charybdotoxin. Grades: ≥96% by HPLC. CAS No. 129203-60-7. Molecular formula: C179H274N50O55S7. Mole weight: 4230.85.
Ibrexafungerp
Ibrexafungerp, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor. Synonyms: Brexafemme; SCY-078; MK3118; 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 15-[(2R)-2-amino-2,3,3-trimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-, (1S, 4aR, 6aS, 7R, 8R, 10aR, 10bR, 12aR, 14R, 15R)-. Grades: ≥95%. CAS No. 1207753-03-4. Molecular formula: C44H67N5O4. Mole weight: 730.03.
Ibrexafungerp Citrate
Ibrexafungerp Citrate, an intravenous and orally bioavailable semisynthetic derivative of enfumafungin, is a triterpene antifungal agent indicated for the treatment of adult and postmenarchal pediatric females with vulvovaginal candidiasis (VVC). It is a glucan synthase inhibitor. Synonyms: Brexafemme Citrate; SCY-078 Citrate; MK-3118 Citrate; 4H-1,4a-Propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid, 15-[(2R)-2-amino-2,3,3-trimethylbutoxy]-8-[(1R)-1,2-dimethylpropyl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-, (1S, 4aR, 6aS, 7R, 8R, 10aR, 10bR, 12aR, 14R, 15R)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt). CAS No. 1965291-08-0. Molecular formula: C50H75N5O11. Mole weight: 922.17.
Ibrutinib
Ibrutinib is a potent and selective BTK inhibitor (IC50=0.5 nM). Synonyms: PCI-32765; PCI 32765; (R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Grades: ≥95%. CAS No. 936563-96-1. Molecular formula: C25H24N6O2. Mole weight: 440.50.
Ibuprofen Carboxylic Acid is the major metabolite of Ibuprofen which may reduce the risk of cataracts by protecting lenticular enzymes. Synonyms: 4-(1-Carboxyethyl)-α-methyl-benzenepropanoic Acid; 2,4'-(2-Carboxypropyl)phenylpropionic Acid; Carboxyibuprofen; 3-[4-(1-Carboxyethyl)phenyl]-2-methylpropionic acid. Grades: > 95%. CAS No. 15935-54-3. Molecular formula: C13H16O4. Mole weight: 236.27.
Ibuprofen Sorbitol Ester is an impurity of ibuprofen. Synonyms: (2S,3R,4R,5R)-2,3,4,5,6-pentahydroxyhexyl 2-[4-(2- methylpropyl)phenyl]propanoate. Grades: > 95%. Molecular formula: C19H30O7. Mole weight: 370.45.
Ibutilide fumarate
Ibutilide Fumarate is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potentia. Uses: Anti-arrhythmia agents. Synonyms: U-70226E; U 70226E; U70226E. Grades: >98%. CAS No. 122647-32-9. Molecular formula: (C20H36N2O3S)2.C4H4O4. Mole weight: 885.23.
Ibutilide Related Compound A
Ibutilide Related Compound A is an intermediate for preparing optically pure Ibutilide fumarate. Synonyms: N-Ethyl-N-heptyl-4-[(methylsulfonyl)amino]-gamma-oxo-benzenebutanamide; 1,4-Diketo Ibutilide; N-Ethyl-N-heptyl-4-(4-(MethylsulfonaMido)phenyl)-4-oxobutanaMide; N-Ethyl-N-heptyl-4-[(methylsulfonyl)amino]-gamma-oxo-benzenebutanamide. Grades: > 95%. CAS No. 100632-58-4. Molecular formula: C20H32N2O4S. Mole weight: 396.55.
Ibutilide Related Compound B
Ibutilide Related Compound B is an intermediate for preparing optically pure Ibutilide fumarate. Synonyms: 4-Keto Ibutilide; (±) -N-Ethyl-N-heptyl-γ -hydroxy-4-[ (Methylsulfonyl) aMino]benzenebutanaMide; N-Ethyl-N-heptyl-γ -hydroxy-4-[ (methylsulfonyl) amino]benzenebutanamide. Grades: > 95%. CAS No. 160087-98-9. Molecular formula: C20H34N2O4S. Mole weight: 398.57.
Icaritin
Icaritin is unable to promote proliferation, migration and tube-like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis. Icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression. In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner. Synonyms: Anhydroicaritin; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3-hydroxy-7-o-beta-glucose-8-prenyl-4''-methoxy Chrysin. Grades: >98%. CAS No. 118525-40-9. Molecular formula: C21H20O6. Mole weight: 368.38.
Idarubicinol is the alcohol analog of Idarubicin, which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor. It is also an analog of Daunorubicin. Synonyms: 5,12-Naphthacenedione, 7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-[(1S)-1-hydroxyethyl]-, (7S,9S)-; (7S,9S)-7-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-[(1S)-1-hydroxyethyl]-5,12-naphthacenedione; 5,12-Naphthacenedione, 7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(1-hydroxyethyl)-, [7S-[7α,9α,9(R*)]]-; 13-Dihydroidarubicin; 4-Demethoxydaunorubicinol; Antibiotic FCE 22723. Grades: > 95%. CAS No. 86189-66-4. Molecular formula: C26H29NO9. Mole weight: 499.52.
IFN-γ Antagonist, derived from the ligand binding site of human γ-interferon (IFN-γ) receptor, is an antagonist of human IFN-γ, and inhibits human IFN-γ-induced expression of HLR/DR antigen on Colo 205 cells with an IC50 of about 35 μM. Synonyms: (Tyr121,Cys(Acm)122)-IFN-γ Receptor (120-141) (human); L-Isoleucine, L-alanyl-L-tyrosyl-S-[(acetylamino)methyl]-L-cysteinyl-L-arginyl-L-α-aspartylglycyl-L-lysyl-L-isoleucylglycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-arginyl-L-lysyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-glutaminyl-; L-alanyl-L-tyrosyl-S-acetamidomethyl-L-cysteinyl-L-arginyl-L-alpha-aspartyl-glycyl-L-lysyl-L-isoleucyl-glycyl-L-prolyl-L-prolyl-L-lysyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-arginyl-L-lysyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-glutaminyl-L-isoleucine; H-Ala-Tyr-Cys(Acm)-Arg-Asp-Gly-Lys-Ile-Gly-Pro-Pro-Lys-Leu-Asp-Ile-Arg-Lys-Glu-Glu-Lys-Gln-Ile-OH. Grades: ≥95%. CAS No. 158040-83-6. Molecular formula: C115H194N34O34S. Mole weight: 2629.04.
Ilaprazole Impurity HCl is pyridine derivative used in the preparation of anti-ulcerative agents and other pharmaceutical compounds. Synonyms: 2-(Chloromethyl)-4-methoxy-3-methylpyridine HCl; Pyridine, 2-(chloromethyl)-4-methoxy-3-methyl-, hydrochloride. Grades: > 95%. CAS No. 86604-74-2. Molecular formula: C8H11Cl2NO. Mole weight: 208.09.