BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Dyrk1A-IN-1 | Dyrk1A-IN-1 is a triple inhibitor of Dyrk1A kinase activity (IC50 = 119 nM) and the aggregation of tau and α-syn oligomers. Synonyms: Dyrk1A-IN-1; CS-0255852. Molecular formula: C23H20N4O3S. Mole weight: 432.49. |  |
| DYRK1-IN-1 | DYRK1-IN-1 is a highly selective and ligand efficient DYRK1A inhibitor that inhibits DYRK1A phosphorylation activity with an IC50 of 220 nM. It can be used to study the central nervous system penetrant DYRK1A chemical probe. Synonyms: N,N-dimethyl-4-(pyrazolo[1,5-b]pyridazin-3-yl)-2-pyrimidinamine. Grade: ≥99%. Molecular formula: C12H12N6. Mole weight: 240.26. | |
| DYRKs-IN-1 | DYRKs-IN-1 is a potent inhibitor of DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. It has antitumor activity. Synonyms: N-{5-[(3-Amino-1-phenylpropyl)carbamoyl]-2-chlorophenyl}-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-1,7-dihydropyrido[2,3-d]pyrimidine-6-carboxamide; Pyrido[2,3-d]pyrimidine-6-carboxamide, N-[5-[[(3-amino-1-phenylpropyl)amino]carbonyl]-2-chlorophenyl]-7,8-dihydro-2-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-7-oxo-. Grade: ≥95%. CAS No. 1387090-01-8. Molecular formula: C30H30ClN7O4. Mole weight: 588.06. | |
| DYRKs-IN-1 hydrochloride | DYRKs-IN-1 hydrochloride is a potent inhibitor of DYRKs (Dual-specificity tyrosine-phosphorylation-regulated kinases) with IC50s of 5 nM and 8 nM for DYRK1A and DYRK1B, respectively. It has antitumor activity. Synonyms: N-(5-((3-amino-1-phenylpropyl)carbamoyl)-2-chlorophenyl)-2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide hydrochloride. Grade: ≥95%. CAS No. 1386980-55-7. Molecular formula: C30H31Cl2N7O4. Mole weight: 624.52. | |
| DYRKs-IN-2 | DYRKs-IN-2 is a potent inhibitor of DYRKs with IC50s of 30.6 nM and 12.8 nM for DYRK1B and DYRK1A, respectively. It has antitumor activity. Synonyms: N-(5-(3-Amino-1-phenylpropylcarbamoyl)-2-chlorophenyl)-2-(3-(4-methylpiperazin-1-yl)propylamino)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide; N-{5-[(3-Amino-1-phenylpropyl)carbamoyl]-2-chlorophenyl}-2-{[3-(4-methyl-1-piperazinyl)propyl]amino}-7-oxo-1,7-dihydropyrido[2,3-d]pyrimidine-6-carboxamide. Grade: ≥95%. CAS No. 1386980-04-6. Molecular formula: C32H38ClN9O3. Mole weight: 632.16. | |
| DZ2002 | DZ2002 is a potent and reversible S-Adenosyl-L-homocysteine Hydrolase(SAHH; AdoHcy Hydrolase) inhibitor with Ki of 17.9 nM. Synonyms: DZ-2002; DZ 2002; DZ2002. Grade: >98%. CAS No. 33231-14-0. Molecular formula: C10H13N5O3. Mole weight: 251.24. | |
| E1231 | E1231 is an orally active activator of Sirtuin 1 (SIRT1) (EC50=0.83 μM). E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Synonyms: 1-{4-[2-(5-methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one. CAS No. 1031195-19-3. Molecular formula: C21H21N3O3. Mole weight: 363.41. | |
| E17110 | E17110 is an LXRβ agonist. E17110 shows a significant activation effect on LXRβ, with an EC50 of 0.72 μmol/L. Synonyms: E-17110; E 17110. Grade: ≥98% by HPLC. Molecular formula: C16H15FN2O5. Mole weight: 334.30. | |
| E 2012 | E 2012, is a potent selective, orally bioavailable γ-secretase modulator without affecting Notch processing that can used to treat Alzheimer's Disease. Synonyms: (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one; 870843-42-8; E 2012; (E)-1-[(1S)-1-(4-FLUOROPHENYL)ETHYL]-3-[3-METHOXY-4-(4-METHYL-1H-IMIDAZOL-1-YL)BENZYLIDENE]PIPERIDIN-2-ONE; UNII-3LSD4Y5F0F; 3LSD4Y5F0F; CHEMBL1224151; E-2012; (e)-1-((1s)-1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1h-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-((1S)-1-(4-Fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene]piperidin-2-one; GTPL7358; SCHEMBL1238634; SCHEMBL1238639; C25H26FN3O2; DTXSID30468614; PUOAETJYKQITMO-LANLRWRYSA-N; (S,E)-1-(1-(4-fluorophenyl)ethyl)-3-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)piperidin-2-one; W-5462; J-501810; I14-15434; (3E)-1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylene]piperidin-2-one; 2-Piperidinone, 1-((1S)-1-(4-fluorophenyl)ethyl)-3-((3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)methylene)-, (3E)-. CAS No. 870843-42-8. Molecular formula: C25H26FN3O2. Mole weight: 419.49. | |
| E260 | E260 is a Fer/FerT kinase inhibitor with Kd of 0.85 uM, which selectively evokes metabolic stress and necrotic death in cancer cells. Synonyms: E260; E 260; E-260; 2-[4-[(4-methylpiperazin-1-yl)methyl]piperidin-1-yl]-6-(4-propan-2-ylphenyl)imidazo[2,1-b][1,3,4]thiadiazole. CAS No. 1241537-79-0. Molecular formula: C24H34N6S. Mole weight: 438.638. | |
| E3330 | E3330 is a potent and selective APE1 (Ref-1) inhibitor, which inhibits NF-κB DNA-binding activity. It blocks TNF-α-induced activation of IL-8 production in liver cancer cell lines and has anticancer properties such as inhibiting the growth and migration of cancer cells. Synonyms: APX-3330; E-3330; E 3330; (2E)-2-[(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene]-undecanoic acid; (E)-2-((4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)methylene)undecanoic acid; Undecanoic acid, 2-((4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)methylene)-, (E)-. Grade: 98%. CAS No. 136164-66-4. Molecular formula: C21H30O6. Mole weight: 378.46. | |
| E 3810 dihydrochloride | E 3810 dihydrochloride is a dual VEGFR/FGFR tyrosine kinase inhibitor. It suppresses the tumor angiogenesis and tumor cell proliferation via inhibiting VEGFR1, -2, and -3 and FGFR-1 and -2 kinases in the nanomolar range. Uses: Antitumor agent. Synonyms: E 3810 dihydrochloride; E3810 dihydrochloride; E-3810 dihydrochloride; Lucitanib dihydrochloride; 6-[7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolin-4-yl]oxy-N-methylnaphthalene-1-carboxamide dihydrochloride. Grade: 99%. CAS No. 2108875-91-6. Molecular formula: C26H25N3O4.2HCl. Mole weight: 516.42. | |
| E-4031 | E-4031, a benzenesulfonamide derivative, could be used as a Class III antiarrhythmic agent due to its effect of blocking the ERG potassium channels. Uses: E-4031 could be used as a class iii antiarrhythmic agent due to its effect of blocking the erg potassium channels. Synonyms: E-4031; E 4031; E4031; 113559-13-0; CHEMBL536480; E-4031dihydrochloride; E-4031; 1-(2-(6-Methyl-2-pyridyl)ethyl)-4-(4-methylsulfonylaminobenzoyl)piperidinedihydrochloride; N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamidedihydrochloride. Grade: 95%. CAS No. 113559-13-0. Molecular formula: C21H29Cl2N3O3S. Mole weight: 474.44. | |
| E4CPG | E4CPG is a group I/group II metabotropic glutamate receptor antagonist with higher potency than (RS)-MCPG. Synonyms: (RS)-α-Ethyl-4-carboxyphenylglycine; 4-(1-amino-1-carboxypropyl)benzoic acid. Grade: ≥99% by HPLC. CAS No. 170846-89-6. Molecular formula: C11H13NO4. Mole weight: 223.23. | |
| E 5555 hydrobromide | E 5555 hydrobromide is a potent and orally bioactive thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50 = 19 nM). It inhibits human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively. Synonyms: Atopaxar hydrobromide; ER 172594-06 HBr; E 5555 hydrobromide; E-5555 hydrobromide; E5555 hydrobromide. Grade: 99%. CAS No. 474550-69-1. Molecular formula: C29H38FN3O5.HBr. Mole weight: 608.54. | |
| E6201 | E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers. Synonyms: E6201; E 6201; E-6201; ER 806201; ER806201; ER-806201; LL-Z1640-2. CAS No. 603987-35-5. Molecular formula: C21H27NO6. Mole weight: 389.45. | |
| E6446 | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E6446; E 6446; E-6446; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazoleBMS-790052; EBP 883; BMS 790052; EBP883; BMS790052; EBP-883; BMS-790052. CAS No. 1219925-73-1. Molecular formula: C27H35N3O3. Mole weight: 449.59. | |
| E6446 dihydrochloride | E6446 is a novel synthetic antagonist for nucleic acid-sensing TLRs. Synonyms: E-6446 dihydrochloride; E 6446 dihydrochloride; E6446 dihydrochloride; 6-(3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl)benzo[d]oxazole dihydrochloride. CAS No. 1345675-25-3. Molecular formula: C27H37Cl2N3O3. Mole weight: 522.51. | |
| E 64c | E-64c is a cysteine protease inhibitor used for detecting autophagy in plants. Synonyms: Loxistatin acid. Grade: 98%. CAS No. 76684-89-4. Molecular formula: C15H26N2O5. Mole weight: 314.38. | |
| E64FC26 | E64FC26 is a highly potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6, respectively. E64FC26 has anti-myeloma activity. Synonyms: (E)-1-Nonylidene-3-(trifluoromethyl)-1H-indene-5,6-diol. Grade: 99%. CAS No. 2285446-62-8. Molecular formula: C19H23F3O2. Mole weight: 340.38. | |
| E67-2 | E67-2, a derivative of E67, is a selective and low-toxicity KIAA1718 Jumonji domain inhibitor with an IC50 of 3.4 μM. E67-2 selectively inhibits histone H3 lysine 9 (H3K9) Jumonji demethylase and histone H3 lysine 4 (H3K4) demethylase. Synonyms: 2,4-Quinazolinediamine, 7-[(5-aminopentyl)oxy]-N2-[3-(dimethylamino)propyl]-6-methoxy-N4,N4-dimethyl-; 7-((5-Aminopentyl)oxy)-N2-(3-(dimethylamino)propyl)-6-methoxy-N4,N4-dimethylquinazoline-2,4-diamine; N-[3-(Dimethylamino)propyl]-N',N'-dimethyl-6-methoxy-7-(5-aminopentyloxy)quinazoline-2,4-diamine. Grade: ≥95%. CAS No. 1364914-62-4. Molecular formula: C21H36N6O2. Mole weight: 404.55. | |
| E6 Berbamine | E6 Berbamine is a calmodulin inhibitor, which is also reported to inhibit P-glycoprotein activity in purified primary cultured rat brain microvessel endothelial cells at 10 μM. Calmodulin is the ubiquitous and multifunctional Ca2+-binding protein, which can mediate various regulatory effects of Ca2+. Synonyms: Berbamine p-nitrobenzoate; O-(4-Nitrobenzoyl)berbamine. Grade: ≥98%. CAS No. 114784-59-7. Molecular formula: C44H43N3O9. Mole weight: 757.8. | |
| E7016 | E7016 is an inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks. Synonyms: E 7016; E-7016; 10-((4-Hydroxypiperidin-1-yl)methyl)chromeno[4,3,2-de]phthalazin-3(2H)-one. Grade: ≥98%. CAS No. 902128-92-1. Molecular formula: C20H19N3O3. Mole weight: 349.39. | |
| E7046 | E7046 is an orally bioavailable and specific type 4 prostaglandin E2 (PGE2) receptor EP antagonist (IC50= 13.5 nM) (Ki= 23.14 nM), with anti-tumor activities. Synonyms: E7046; E-7046; E 7046. 4-[(1S)-1-[[3-(difluoromethyl)-1-methyl-5-[3-(trifluoromethyl)phenoxy]pyrazole-4-carbonyl]amino]ethyl]benzoic acid. CAS No. 1369489-71-3. Molecular formula: C22H18F5N3O4. Mole weight: 483.39. | |
| E-7050 (2S,3S)-2,3-dihydroxysuccinic acid | E-7050 (2S,3S)-2,3-dihydroxysuccinic acid is the salt form of Golvatinib, which is an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. Synonyms: 1,1-Cyclopropanedicarboxamide, N-[2-fluoro-4-[[2-[[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]amino]-4-pyridinyl]oxy]phenyl]-N'-(4-fluorophenyl)-, (2S,3S)-2,3-dihydroxybutanedioate (1:1); N-[2-Fluoro-4-[[2-[[[4-(4-methylpiperazin-1-yl)piperidin-1-yl]carbonyl]amino]pyridin-4-yl]oxy]phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (2S,3S)-tartrate; Golvatinib D-Tartaric acid; Golvatinib (2S,3S)-2,3-dihydroxysuccinic acid. Grade: 95%. CAS No. 1007601-97-9. Molecular formula: C33H37F2N7O4.C4H6O6. Mole weight: 783.78. | |
| E7090 succinate | E7090 succinate is a potent, selective and orally available inhibitor of FGFR1, FGFR2 and FGFR3 tyrosine kinase activities, with IC50s of 0.71, 0.50, 1.2 and 120 nM for FGFR1/2/3/4, respectively. Synonyms: 5-((2-(((4-(1-(2-Hydroxyethyl)piperidin-4-yl)phenyl)carbonyl)amino)pyridin-4-yl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide succinate (1:1.5); Butanedioic acid, compd. with 5-((2-((4-(1-(2-hydroxyethyl)-4-piperidinyl)benzoyl)amino)-4-pyridinyl)oxy)-6-(2-methoxyethoxy)-N-methyl-1H-indole-1-carboxamide (3:2). CAS No. 1879965-80-6. Molecular formula: C32H37N5O6.1.5(C4H6O4). Mole weight: 764.82. | |
| E7449 | E7449 is an orally bioavailable, potent, small molecule inhibitor of PARP1 and PARP2, which enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Synonyms: E7449; E 7449; E-7449; 2X-121; 2X 121; 2X121. Grade: >98%. CAS No. 1140964-99-3. Molecular formula: C18H15N5O. Mole weight: 317.34. | |
| E7449 mesylate | E7449 mesylate is a dual inhibitor of PARP1/2 and tankyrase1/2. E7449 inhibits PARP enzymatic activity and additionally traps PARP1 onto damaged DNA. E7449 inhibited Wnt/β-catenin signaling in colon cancer cell lines, likely through TNKS inhibition. Synonyms: 2X-121; 8-(Isoindolin-2-ylmethyl)-2H-pyridazino[3,4,5-de]quinazolin-3(9H)-one methanesulfonate. Grade: 98%. CAS No. 1140965-47-4. Molecular formula: C18H15N5O.CH4O3S. Mole weight: 413.45. | |
| E7766 diammonium salt | E7766 diammonium salt is one of macrocycle-bridged stimulator of interferon genes (STING) agonist with potent pan-genotypic activity. Grade: 98%. CAS No. 2242635-03-4. Molecular formula: C24H32F2N12O8P2S2. Mole weight: 780.66. | |
| E7766 disodium | E7766 disodium is one of macrocycle-bridged stimulator of interferon genes (STING) agonist with potent pan-genotypic activity. Synonyms: E7766 (disodium). CAS No. 2242636-28-6. Molecular formula: C24H26F2N10Na2O8P2S2. Mole weight: 792.58. | |
| E 7820 | E7820 is an orally active unique angiogenesis inhibitor that inhibits the expression of integrin α2 subunit on endothelial cells and has antiangiogenic and antitumor activities. E7820 regulates the expression of α-1, α-2, α-3 and α-5 integrin mRNA, and inhibits rat aortic angiogenesis with an IC50 of 0.11 μg/mL. Synonyms: ER68203-00; N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzene-sulfonamide; NSC-719239; 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide; Benzenesulfonamide, 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)-. Grade: ≥95%. CAS No. 289483-69-8. Molecular formula: C17H12N4O2S. Mole weight: 336.37. | |
| E7974 | E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. Synonyms: E 7974; E-7974; (S,E)-4-((S)-2-((R)-1-isopropylpiperidine-2-carboxamido)-N,3,3-trimethylbutanamido)-2,5-dimethylhex-2-enoic acid. CAS No. 610787-07-0. Molecular formula: C24H43N3O4. Mole weight: 437.62. | |
| E-982 | E-982 is a potent and selective inhibitor designed for the research of prostate cancer. This product exhibits high binding specificity to the androgen receptor, preventing its activation and subsequent tumor growth. Synonyms: E982; E 982; E-982. Grade: >98 %. CAS No. 858102-78-0. Molecular formula: C25H31NO6S. Mole weight: 473.58. | |
| EA4 | EA4 is a rPLA2 inhibitor, and it is a quinone derivative. rPLA2, a calcium-dependent cytosolic phospholipase A2 (cPLA2), was initially isolated and characterized from bovine and human red blood cells (RBCs). EA4 inhibits the ionophore-induced arachidonic acid release from human and bovine red blood cells (RBCs), indicating that rPLA2 is responsible for the Ca2+-dependent release of arachidonic acid from mammalian RBCs. Synonyms: 7-chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione. Grade: ≥95%. CAS No. 389614-94-2. Molecular formula: C19H17ClN2O2. Mole weight: 340.8. | |
| EAAT2 activator 1 | EAAT2 activator 1 is a potent activator of the excitatory amino acid transporter 2 (EAAT2) and dose-dependently increases EAAT2 protein levels. EAAT2 is a major glutamate transporter whose function is to remove glutamate from synapses. Synonyms: 3-[(2-chloro-6-fluorophenyl)methylsulfanyl]-6-pyridin-2-ylpyridazine; Pyridazine, 3-[[(2-chloro-6-fluorophenyl)methyl]thio]-6-(2-pyridinyl)-; 3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-6-(2-pyridinyl)pyridazine. Grade: ≥98%. CAS No. 892415-28-0. Molecular formula: C16H11ClFN3S. Mole weight: 331.80. | |
| Eact | Eact is a TMEM16A (ANO1) calcium-activated chloride channel (CaCC) activator (EC50 = 3 μM). Eact also stimulates transient receptor potential vanilloid 1 (TRPV1) channel activator (EC50 = 11.6 μM). Stimulates submucosal gland secretion in human bronchi. Synonyms: 3,4,5-Trimethoxy-N-(2-methoxyethyl)-N-(4-phenyl-2-thiazolyl)benzamide. Grade: ≥99% by HPLC. CAS No. 461000-66-8. Molecular formula: C22H24N2O5S. Mole weight: 428.5. | |
| EAD-1 | EAD-1, a chloroquinoline derivative, has been found to be an autophagy inhibitor that exhibit antiproliferative effct in lung and pancreatic cancer cells so that could be significant in anticancer studies. Synonyms: EAD1; EAD-1; EAD 1; N1-((1-(4-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine. Grade: 98%. CAS No. 1644388-26-0. Molecular formula: C24H27Cl2N7. Mole weight: 484.43. | |
| EAD1 HCl | EAD1 HCl is an effective autophagy inhibitor with IC50 of 5.8 μM. It has antiproliferative activity in lung and pancreatic cancer cells. Grade: >95.0%. Molecular formula: C24H28Cl3N7. Mole weight: 520.89. | |
| EAD-1 TFA | EAD-1 is a potent and selective inhibitor of autophagy (IC50 = 5.8 μM in the BxPC3 cells) with antiproliferative activity in lung and pancreatic cancer cells. Synonyms: N-[[1-[(4-chlorophenyl)methyl]triazol-4-yl]methyl]-N'-[2-[(7-chloroquinolin-4-yl)amino]ethyl]-N'-methylethane-1,2-diamine; 2,2,2-trifluoroacetic acid. Grade: ≥98%. Molecular formula: C26H28Cl2F3N7O2. Mole weight: 598.45. | |
| EAI045 | EAI045 is an allosteric, non-ATP competitive inhibitor of mutant EGFR. In vitro studies proved that EAI045 is active and selective for T790M- harboring EGFR mutants that are in a monomer state. In vivo the combination of EAI045 and cetuximab caused a marked tumor shrinkage in a mouse model carrying the EGFR mutant with L858R/T790M/C797S. Therefore, EAI045 is the first allosteric inhibitor that targets T790M and C797S EGFR mutants but it is effective only in combination with cetuximab. Synonyms: 2-(5-fluoro-2-hydroxyphenyl)-2-(3-oxo-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; 2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; EAI045; EAI 045; EAI-045. CAS No. 1942114-09-1. Molecular formula: C19H14FN3O3S. Mole weight: 383.397. | |
| EB-3D | EB-3D is a potent and selective inhibitor of choline kinase α (ChoKα). EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. Synonyms: 1,1'-(((Ethane-1,2-diylbis(oxy))bis(4,1-phenylene))bis(methylene))bis(4-(dimethylamino)pyridin-1-ium) bromide. CAS No. 1839150-63-8. Molecular formula: C30H36Br2N4O2. Mole weight: 644.44. | |
| EB-42486 | EB-42486 is a potent and highly selective inhibitor of G2019S-LRRK2 with an IC50 of <0.2 nM. Synonyms: Tetrazolo[1,5-a]pyrimidine-6-carboxamide, 4,7-dihydro-4,5,7,7-tetramethyl-N-(3-phenyl-1H-indazol-5-yl)-. CAS No. 2390475-81-5. Molecular formula: C22H22N8O. Mole weight: 414.46. | |
| EB 47 | EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide. CAS No. 366454-36-6. Molecular formula: C24H27N9O6. Mole weight: 537.53. | |
| EB 47-d8 | Isotope labelled EB 47 is a potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1). Poly(ADP-ribose) polymerases (PARPs) play a major role in cellular survival and maintenance of energy stores after genotoxic insult. Synonyms: 5'-Deoxy-5'-[4-[2-[(2,3-dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine-d8; 4-[1-(6-Amino-9H-purin-9-yl)-1-deoxy-β-D-ribofuranuronoyl]-N-(2,3-dihydro-1-oxo-1H-isoindol-4-yl)-1-piperazineacetamide-d8. Molecular formula: C24H19D8N9O6. Mole weight: 545.58. | |
| EB 47 dihydrochloride | EB 47 dihydrochloride is a PARP-1 inhibitor (IC50 = 45 nM) that reduces infarct volume in both a rat transient middle cerebral arterial occlusion model and a cardiac reperfusion model. Synonyms: EB 47 dihydrochloride; EB47 dihydrochloride; EB-47 dihydrochloride; 5'-Deoxy-5'-[4-[2-[(2,3-Dihydro-1-oxo-1H-isoindol-4-yl)amino]-2-oxoethyl]-1-piperazinyl]-5'-oxoadenosine dihydrochloride. Grade: ≥99% by HPLC. CAS No. 1190332-25-2. Molecular formula: C24H27N9O6.2HCl. Mole weight: 610.45. | |
| Ebastine | Ebastine is a nonsedating type histamine H1-receptor antagonist. Uses: Histamine h1 antagonists. Synonyms: RP64305; RP-64305; RP 64305; LAS W-090; Ebastine; Brand name: Evastin; Kestine; Ebastel; Aleva; Ebatrol; Bactil; Busidril; Ebastel; Evastel; Kestin; Kestine. Grade: >98%. CAS No. 90729-43-4. Molecular formula: C32H39NO2. Mole weight: 469.66. | |
| Ebastine Impurity B (4'-tert-Butylacetophenone) | 4-tert-Butylacetophenone is an impurity arising in the synthesis of Ebastine. Synonyms: 1-[4-(1,1-Dimethylethyl)phenyl]ethanone; 1-(4-tert-Butylphenyl)ethanone; 4-tert-Butylphenyl Methyl Ketone. Grade: > 95%. CAS No. 943-27-1. Molecular formula: C12H16O. Mole weight: 176.25. | |
| EBE-A22 | The brominated anilinoquinazoline derivative PD153035 exhibits a very high affinity and selectivity for the epidermal growth factor receptor tyrosine kinase (EGF-R TK) and shows a remarkable cytotoxicity against several types of tumor cell lines. Uses: Intercalating agents. Synonyms: EBE-A22; EBE A22; EBEA22. Grade: >98%. CAS No. 229476-53-3. Molecular formula: C17H16BrN3O2. Mole weight: 374.23. | |
| Eberconazole | Eberconazole, a dichlorinated imidazole derivative with antifungal activity, is more active than Clotrimazole, Ketoconazole and Miconazole. It has the potential for the study of dermatophytoses with a topical administration. Synonyms: 1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-yl)-1H-imidazole; (±)-1-(2,4-Dichloro-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-yl)imidazole; 1H-Imidazole, 1-(2,4-dichloro-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-. Grade: 95%. CAS No. 128326-82-9. Molecular formula: C18H14Cl2N2. Mole weight: 329.22. | |
| EBI-2511 | EBI-2511 is a highly potent and orally active EZH2 inhibitor (IC50 = 4 nM). Synonyms: EBI2511; N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-ethyl-6-(ethyl(tetrahydro-2H-pyran-4- yl)amino)-2-(1-isopropylpiperidin-4-yl)benzofuran-4-carboxamide. Grade: ≥98%. CAS No. 2098546-05-3. Molecular formula: C34H48N4O4. Mole weight: 576.77. | |
| EBI-907 | EBI-907, an isoquinolin derivative, has been found to be a B-RafV600E inhibitor and exhibit activities against some oncogenic kinases at some extent. The researches of it against breast cancer is still in progress. Synonyms: EBI-907; EBI 907; EBI907; N-(2-chloro-3-(1-cyclopropyl-8-methoxy-3H-pyrazolo[3,4-c]isoquinolin-7-yl)-4-fluorophenyl)-3-fluoropropane-1-sulfonamide. Grade: 98%. CAS No. 1581764-31-9. Molecular formula: C23H21ClF2N4O3S. Mole weight: 506.95. | |
| EBOV/MARV-IN-1 | EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) with EC50s of 0.31 and 0.82 μM, respectively. It has broad-spectrum activity and low cytotoxicity (SI>100) in HeLa cells. Synonyms: VUN65671; VUN-65671; VUN 65671; N-[4-(4-Methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)benzamide; Benzamide, N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)-. Grade: ≥95%. CAS No. 2479465-67-1. Molecular formula: C25H30F3N3O2. Mole weight: 461.52. | |
| EBPC | EBPC is a potent and selective aldose reductase inhibitor. It is used to improve the cytotoxicity of anticancer reagents such as cisplatin and doxorubicin in HeLa cervical carcinoma cells via an increase in ERK activity. Synonyms: Ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate; 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester; MFCD00179167; 1-benzyl-4-[ethoxy(hydroxy)methylidene]pyrrolidine-2,3-dione. Grade: ≥99% by HPLC. CAS No. 4450-98-0. Molecular formula: C14H15NO4. Mole weight: 261.28. | |
| Ebrotidine | Ebrotidine(FI 3542), a competitive H2-receptor antagonist, has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. IC50: 127.5 nM (Ki)[1]; 0.21mg/kg (ED50, histamine- stimulated acid secretion). It also. Uses: Ebrotidine(fi 3542) is a competitive h2-receptor antagonist and has gastroprotective activity under the condition of gastric mucosal damage caused by some stress responses. Synonyms: FI-3542; FI 3542; FI3542; Ebrotidine. Grade: 95%. CAS No. 100981-43-9. Molecular formula: C14H17BrN6O2S3. Mole weight: 477.43. | |
| Ebselen | Ebselen, also known as SPI-1005, is an organoselenium compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. Upon oral administration of SPI-1005, this agent mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation. Synonyms: SPI-1005; SPI1005; SPI 1005; Ebselen; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305. Grade: >98%. CAS No. 60940-34-3. Molecular formula: C13H9NOSe. Mole weight: 274.192. | |
| Ebvaciclib | Ebvaciclib is a cyclin-dependent kinase 2 (CDK2) inhibitor with antineoplastic activity. It is active against CDK2, CDK4, and CDK6 with Kis of 0.13, 1.25, and 0.11 nM, respectively. Synonyms: PF-06873600; PF 06873600; PF06873600. CAS No. 2185857-97-8. Molecular formula: C20H27F2N5O4S. Mole weight: 471.52. | |
| EC 144 | EC 114 is a high affinity, potent and selective Hsp90 inhibitor. IC50 1.1 nM. It exhibits selectivity for Hsp90 over Grp94 and TRAP1 (Ki values are 61 and 255 nM respectively) and has no effect (IC50 > 10μM) against a panel of 285 kinases. Degrades Her-2 in MCF-7 breast cancer cells (EC50 = 14 nM). Blocks tumor growth and induces partial tumor regression in an N87 gastric tumor mouse model. Also inhibits LPS-induced TNFα release in an LPS shock mouse model and suppresses disease development in a rat model of collagen-induced arthritis. Exhibits < 20-fold efficacy over BIIB 021 in mice. Orally available and brain penetrant. Synonyms: EC144; EC-144; EC 144; Alkyne 40; Alkyne-40; Alkyne40. Grade:>98%. CAS No. 911397-80-3. Molecular formula: C21H24ClN5O2. Mole weight: 413.90. | |
| EC-17 | EC17, also known as Folate-FITC, is a conjugate consisting of fluorescein isothiocyanate (FITC) conjugated with folate with potential antineoplastic activity. Folate-FITC binds to folate receptors, which are overexpressed on the surfaces of many cancer cells including kidney and ovarian cancer cells. Once bound to the cancer cell through the folate moiety of the conjugate, curculating anti-fluorescein antibodies.may recognize and bind to the FITC moiety, resulting in antibody-dependent cellular cytotoxicity. Synonyms: EC17; EC 17; Folate-FITC; Folate-fluorescein conjugate. CAS No. 583037-91-6. Molecular formula: C42H36N10O10S. Mole weight: 872.87. | |
| EC-17 Disodium salt | EC-17 disodium salt is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. Synonyms: Folate-FTIC Disodium salt; FTIC-Folate Disodium salt. CAS No. 910661-33-5. Molecular formula: C42H34N10Na2O10S. Mole weight: 916.83. | |
| EC2629 | EC2629 is a highly potent folate receptor (FR)-targeted DNA crosslinking agent for the study of FR-positive tumors, including drug-resistant tumors. Synonyms: AKOS040757473; 2245361-43-5. CAS No. 2245361-43-5. Molecular formula: C103H138N24O35S3. Mole weight: 2368.53. | |
| Ec2la | Ec2la is a positive allosteric modulator of CB2 receptor. It enhances CP 55940 and 2-Arachidonylglycerol-stimulated binding of [35S]GTPγS to CB2 receptors, but doesn't have effect in the absence of agonist. Synonyms: N-[5-Bromo-1-[(4-fluorophenyl)methyl]-1,2-dihydro-4-methyl-2-oxo-3-pyridinyl]cycloheptanecarboxamide. Grade: ≥98% by HPLC. CAS No. 2244579-87-9. Molecular formula: C21H24BrFN2O2. Mole weight: 435.33. | |
| EC330 | EC330 is a novel steroidal LIF inhibitor showed cytotoxicity in various cancer cell lines and NCI-60 cell line panel at low nano-molar range, blocked formation of colonies in soft agar and inhibited angiogenesis (tube formation) in HUVEC cells. EC330 as a novel LIF inhibitor has targeted therapeutic perspectives for patients with aggressive primary tumors. Synonyms: EC330; EC 330; EC-330; (8S,11R,13S,14S,17S)-11-(4-cyclopropylphenyl)-17-(1,1-difluoroprop-2-ynyl)-17-hydroxy-13-methyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one. CAS No. 2016795-77-8. Molecular formula: C30H32F2O2. Mole weight: 462.57. | |
| EC5026 | EC5026 is an inhibitor of soluble epoxide hydrolase (sEH). Inhibition of sEH increases epoxides of polyunsaturated fatty acids (EpFA) in vivo and confers beneficial effects. Synonyms: EC-5026; EC 5026. Grade: 98% by HPLC. CAS No. 1809885-32-2. Molecular formula: C18H23F4N3O3. Mole weight: 405.4. | |
| Ecabet sodium | Ecabet sodium is a Prostaglandin agonist under the development of Mitsubishi Tanabe Pharma Corporation. Now ecabet sodium is marketed in Japan a for treatment of gastric ulcers and gastritis. Uses: Gastric ulcer; gastritis. Synonyms: 1-Phenanthrenecarboxylic acid, 1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-, (1R-(1-alpha,4a-beta,10a-alpha))-, monosodium salt; Sulfodehydroabietic acid monosodium salt. Grade: 98%. CAS No. 86408-72-2. Molecular formula: C20H27NaO5S. Mole weight: 402.48. | |
| Ecadotril | Ecadotril is a neutral endopeptidase(NEP) inhibitor and determined by the presence of peptidase family M13 as a neutral endopeptidase inhibited by phosphoramidon. lt is the (S)-enantiomer of racecadotril. It acts as an antihypertensive. Uses: Ecadotril acts as an antihypertensive. Synonyms: Ecadotril; BAY y 7432; BAY-y 7432; BP 1.02; S049; S.049; Sinorphan; N-[(S)-2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl]glycine benzyl ester; S-Acetorphan; Sinorphan; Benzyl 2-[[(2S)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate; Glycine, N-(2-((acetylthio)methyl)-1-oxo-3-phenylpropyl)-, phenylmethyl ester, (S)-. Grade: 95%. CAS No. 112573-73-6. Molecular formula: C21H23NO4S. Mole weight: 385.48. | |
| Ecastolol | Ecastolol is a beta adrenergic receptor antagonist. Synonyms: (+-)-4'-(3-((3,4-Dimethoxyphenethyl)amino)-2-hydroxypropoxy)-3'-(5-isoxazolyl)butyranilide. CAS No. 77695-52-4. Molecular formula: C26H33N3O6. Mole weight: 483.56. | |
| E-Ceftizoxime Sodium Salt | an impurity of ceftizoxime. Synonyms: 5-Thia-1-azabicyclo[4.2.0]?oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)?(methoxyimino)?acetyl]?amino]?-8-oxo-, monosodium salt, [6R-[6α,?7β(E)?]?]?- (9CI). Grade: > 95%. CAS No. 97164-53-9. Molecular formula: C13H12N5O5S2. Na. Mole weight: 382.40 22.99. | |
| eCF309 | eCF309 is a potent and cell-permeable inhibitor of mTOR signaling (IC50 value 10 - 15 nM in vitro and in vivo) that exhibits >60-fold selectivity over PI3Ks. It is used as a highly valuable probe for chemical biology and biomedicine for its more potent activity compared to other mTOR inhibitors. Uses: Antitumor agent. Synonyms: 5-[4-amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amine; ECF 309; ECF-309; GTPL9571. Grade: 98%. CAS No. 2001571-40-8. Molecular formula: C18H21N7O3. Mole weight: 383.4. | |
| eCF506 | eCF506 is a potent and highl selective inhibitor towards Src tyrosine kinase with a 1000-fold selectivity over ABL. eCF506 inhibits SRC at subnanomolar concentration (IC50 < 0.5 nM). It is said that eCF506 is the first drug candidate of a second generation of Src inhibitors that will not only help to understand the complexity of some cancers but also the development of safer combination therapies. Synonyms: eCF506; eCF-506; eCF 506.; tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamate; eCF506; Derivative 11a; GTPL9186; derivative 11a [PMID: 27115835]; tert-butyl N-[4-(4-amino-1-{2-[4-(dimethylamino)piperidin-1-yl]ethyl}-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl]carbamate. Grade:>98%. CAS No. 1914078-41-3. Molecular formula: C26H38N8O3. Mole weight: 510.643. | |
| Echimidine N-oxide | (+)-Echimidine N-Oxide is a hepatotoxic pyrrolizidine alkaloid. It has acetylcholinesterase (AChE) inhibitory activity (IC50 = 0.347 mM). Synonyms: (+)-Echimidine N-Oxide; 2-Butenoic acid, 2-methyl-, 7-((2,3-dihydroxy-2-(1-hydroxyethyl)-3-methyl-1-oxobutoxyl)methyl)-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl ester, N-oxide. CAS No. 41093-89-4. Molecular formula: C20H31NO8. Mole weight: 413.46. | |
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