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| Product | Description | |
|---|---|---|
| Ezetimibe Azetidinone Ring-opened Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L8) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe Azetidinone Ring-opened Sodium Salt Impurity (Technical Grade, >75%). Grade: > 95%. CAS No. 1391053-63-6. Molecular formula: C24H23F2NO4. Mole weight: 427.45. |  |
| Ezetimibe Benzyl Impurity (MBZT-2) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L32) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-3-(3-(benzyloxy)-3-(4-fluorophenyl)propyl)-1-(3-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. CAS No. 851860-29-2. Molecular formula: C31H27F2NO3. Mole weight: 499.56. | |
| Ezetimibe-d4 phenolic glucuronide | One of the isotope labelled impurities of Ezetimibe, which could be used as an antihyperlipoproteinemic agent. Synonyms: 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-D-Glucopyranosiduronic Acid-d4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.58. | |
| Ezetimibe Dehydoxy Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L16) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3-Dehydroxy Ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)propyl]-4-(4-hydroxyphenyl)-2-azetidinone. Grade: > 95%. CAS No. 204589-58-2. Molecular formula: C24H21F2NO2. Mole weight: 393.44. | |
| Ezetimibe Deprotected Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L13) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((2R,5S)-5-(4-fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. Grade: 95%. CAS No. 1185883-40-2. Molecular formula: C33H30F2N2O5. Mole weight: 572.61. | |
| Ezetimibe Desfluoro Chloro Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L29) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: N-Des(4-Fluorophenyl)-N-(3-chlorophenyl)-ezetimibe; (3R,4S)-1-(4-chlorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H21ClFNO3. Mole weight: 425.89. | |
| Ezetimibe Desfluoro Dehydoxy Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L45) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-3-((S)-3-(benzyloxy)-3-(4-fluorophenyl)propyl)-1-(3-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H22FNO2. Mole weight: 375.45. | |
| Ezetimibe Desfluoro Methyl Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L30) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 4"DeFluoro-4"methyl-ezetimibe; (3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-hydroxy-3-(p-tolyl)propyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. CAS No. 1700622-07-6. Molecular formula: C25H24FNO3. Mole weight: 405.47. | |
| Ezetimibe-D-glucuronide-[d4] | Ezetimibe-D-glucuronide-[d4] is an esteemed compound in the biomedical field, aiding in the research of hypercholesterolemia and familial hypercholesterolemia. Manifesting as a remarkable cholesterol absorption inhibitor, it deftly curtails cholesterol levels through the hindrance of intestinal cholesterol assimilation and associated phytosterol uptake. Synonyms: Ezetimibe-d4 β-D-Glucuronide; Ezetimibe-D-glucuronide D4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Diacetate | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L5) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-3-[(3S)-3-(Acetyloxy)-3-(4-fluorophenyl)propyl]-4-[4-(acetyloxy)phenyl]-1-(4-fluorophenyl)-2-azetidinone. Grade: > 95%. CAS No. 163380-20-9. Molecular formula: C28H25F2NO5. Mole weight: 493.51. | |
| Ezetimibe Diacid Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: ((2R,3S)-2-[(4-Benzyloxyphenyl)-4-(4-Fluorophenylamino)methyl]pentanedioic acid). Grade: > 95%. CAS No. 1013025-04-1. Molecular formula: C25H24FNO5. Mole weight: 437.47. | |
| Ezetimibe diastereomers | An impurity of Ezetimibe. Ezetimibe is a selective cholesterol absorption inhibitor that targets the Niemann-Pick C1-Like 1 (NPC1L1) protein in the small intestine, blocking dietary and biliary cholesterol uptake. Synonyms: Ezetimibe R,R,R- and S,S,S-isomer; R,R,R-Ezetimibe and S,S,S-Ezetimibe; (3S,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one and (3R,4R)-1-(4-Fluorophenyl)-3-[(R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; S,S,S-Ezetimibe and R,R,R-Ezetimibe. Grade: ≥95%. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe Diol | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L22) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (1S,4R)-1-(4-Fluorophenyl)-4-[(S)-[(4-fluorophenyl)amino](4-hydroxyphenyl)methyl]-1,5-pentanediol. Grade: > 95%. CAS No. 1374250-08-4. Molecular formula: C24H25F2NO3. Mole weight: 413.47. | |
| Ezetimibe Fluoro Isomer | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L9) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-1-(4-Fluorophenyl)-3-[(S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one; 2-Azetidinone, 1-(4-fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-, (3R,4S)-; (3R,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(2-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone; Ezetimibe o-Fluorobenzene isomer; O-Fluorobenzene ezetimibe; Ezetimibe ortho-Fluorobenzene Isomer; 3'-(2-Fluorophenyl) Ezetimibe. Grade: ≥95%. CAS No. 2743547-96-6. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe hydroxy-D-glucuronide-[d4] | Ezetimibe hydroxy-D-glucuronide-[d4] is a metabolite of stable isotope-labeled Ezetimibe, playing a profound role in illuminating the intricate mechanisms of Ezetimibe metabolism, pharmacokinetics and elimination pathways. Synonyms: Ezetimibe hydroxy-D-glucuronide D4. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Hydroxy Glucuronide | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe Hydroxy β-D-Glucuronide; (1S)-1-(4-Fluorophenyl)-3-[(2S,3R)-1-(4-fluorophenyl)-2-(4-hydroxyphenyl)-4-oxo-3-azetidinyl]propyl β-D-Glucopyranosiduronic Acid. Grade: > 95%. CAS No. 536709-33-8. Molecular formula: C30H29F2NO9. Mole weight: 585.55. | |
| Ezetimibe Impurity 10 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L44) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C18H18FNO3. Mole weight: 315.35. | |
| Ezetimibe Impurity 2 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L17) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-oxo-3-phenylpropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H26FNO3. Mole weight: 479.56. | |
| Ezetimibe Impurity 3 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L18) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-4-(4-(benzyloxy)phenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-1-phenylazetidin-2-one. Grade: > 95%. Molecular formula: C31H26FNO3. Mole weight: 479.56. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(R)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L38) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4R)-4-Phenyl-3-[(5R)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(R)-hydroxy-pentanoyl]-4-(S)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L36) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((R)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one. Grade: > 95%. CAS No. 528565-93-7. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(R)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L37) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4R)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. CAS No. 189028-95-3. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe impurity (3-[5-(4-Fluoro-phenyl)-5-(S)-hydroxy-pentanoyl]-4-(S)-phenyl-oxazolidin-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L39) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (4S)-4-Phenyl-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-1,3-oxazolidin-2-one. Grade: > 95%. Molecular formula: C20H20FNO4. Mole weight: 357.39. | |
| Ezetimibe Impurity 4 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L19) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3S,4R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H25F2NO3. Mole weight: 497.55. | |
| Ezetimibe Impurity 5 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L20) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-hydroxypropyl)azetidin-2-one. Grade: > 95%. Molecular formula: C31H27F2NO3. Mole weight: 499.56. | |
| Ezetimibe Impurity 8 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L42) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-1-(4-fluorophenyl)-5-(2-oxo-4-phenyloxazolidin-3-yl)pentane-1,5-dione. Grade: > 95%. CAS No. 189028-93-1. Molecular formula: C20H18FNO4. Mole weight: 355.37. | |
| Ezetimibe Impurity 8 Enantiomer | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L46) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3-[5-(1,5-Dioxo-5-(p-fluophenylpentyl]-4R-phenyl-2-oxazolidinone. Grade: > 95%. CAS No. 404874-93-7. Molecular formula: C20H18FNO4. Mole weight: 355.37. | |
| Ezetimibe Impurity 9 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L43) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (S)-3-((2R,5S)-5-(4-Fluorophenyl)-2-((S)-((4-fluorophenyl)amino)(4-((trimethylsilyl)oxy)phenyl)methyl)-5-((trimethylsilyl)oxy)pentanoyl)-4-phenyloxazolidin-2-one; 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone. Grade: > 95%. CAS No. 272778-12-8. Molecular formula: C39H46F2N2O5Si2. Mole weight: 716.98. | |
| Ezetimibe Impurity B | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L14) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: methyl 5-(4-fluorophenyl)-5-hydroxypentanoate. Grade: > 95%. CAS No. 870634-36-9. Molecular formula: C12H15FO3. Mole weight: 226.25. | |
| Ezetimibe Impurity (Tetrahydro-pyran-2-one) | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L35) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,6R)-6-(4-fluorophenyl)-3-((S)-((4-fluorophenyl)amino)(4-hydroxyphenyl)methyl)tetrahydro-2H-pyran-2-one. Grade: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe Ketone | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)azetidin-2-one; (3R,4S)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone; EZM-K; Ezetimibe 3-Oxo Impurity; 2-Azetidinone, 1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-, (3R-trans)-. Grade: >95%. CAS No. 191330-56-0. Molecular formula: C24H19F2NO3. Mole weight: 407.42. | |
| Ezetimibe Lactam Cleaved Alcohol | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L23) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 3'-Anhydro Ezetimibe Alcohol Impurity; (βR,γS)-γ-[(4-Fluorophenyl)amino]-β-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanol. Grade: > 95%. CAS No. 1374250-07-3. Molecular formula: C24H23F2NO2. Mole weight: 395.45. | |
| Ezetimibe phenoxy glucuronide | A metabolite of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 4-[(2S,3R)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-oxo-2-azetidinyl]phenyl β-D-glucopyranosiduronic acid; Ezetimibe glucuronide; Sch 58235 glucuronide; Sch 60663; Ezetimibe β-D-Glucuronide; Ezetimibe phenoxy-β-D-glucuronide. Grade: >95%. CAS No. 190448-57-8. Molecular formula: C30H29F2NO9. Mole weight: 585.55. | |
| Ezetimibe Phenoxy Glucuronide-[d4] | Ezetimibe Phenoxy Glucuronide-[d4] is the labelled analogue of Ezetimibe Phenoxy Glucuronide, which is a metabolite of Ezetimibe. Ezetimibe is a medication used to treat high blood cholesterol and certain other lipid abnormalities. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: Ezetimibe D4 Phenoxy Glucuronide. Grade: 95% by HPLC; 98% atom D. CAS No. 1426174-41-5. Molecular formula: C30H25D4F2NO9. Mole weight: 589.57. | |
| Ezetimibe Related Impurity 6 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L40) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((S)-3-(3-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe Related Impurity 7 | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L41) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R)-1-(3-fluorophenyl)-3-((E)-3-(3-fluorophenyl)allyl)-4-(4-hydroxyphenyl)azetidin-2-one. Grade: > 95%. CAS No. 204589-68-4. Molecular formula: C24H19F2NO2. Mole weight: 391.42. | |
| Ezetimibe Ring-Open Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L15) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: 2-(4-Hydroxybenzyl)-N,5-bis-(4-fluorophenyl)-5-hydroxypentanamide. Grade: > 95%. CAS No. 1197811-72-5. Molecular formula: C24H23FNO3. Mole weight: 411.45. | |
| Ezetimibe ring-opening dehydrate impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L31) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (αR,βS)-β-[(4-Fluorophenyl)amino]-α-[3-(4-fluorophenyl)-2-propen-1-yl]-4-hydroxybenzenepropanoic Acid. Grade: > 95%. CAS No. 1292292-63-7. Molecular formula: C24H21F2NO3. Mole weight: 409.44. | |
| Ezetimibe tetrahydropyran analog | An impurity of Ezetimibe. Ezetimibe is a cholesterol absorption inhibitor used to reduce low-density lipoprotein (LDL) cholesterol levels in the blood. It is commonly used alone or in combination with other cholesterol-lowering medications, such as statins, to manage hypercholesterolemia and related conditions. Synonyms: N,6-Bis(4-fluorophenyl)-2-(4-hydroxyphenyl)tetrahydro-2H-pyran-3-carboxamide; Ezetimibe Tetrahydropyran Impurity; Ezetimibe THP analog; Ezetimibe Cyclized Impurity; Ezetimibe Cyclic ether; Ezetimibe Cyclic Ether Impurity; N,6-Bis(4-fluorophenyl)tetrahydro-2-(4-hydroxyphenyl)-2H-pyran-3-carboxamide. Grade: ≥95%. CAS No. 1050631-82-7. Molecular formula: C24H21F2NO3. Mole weight: 409.43. | |
| Ezetimibe Triol Impurity | An impurity of Ezetimibe. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L48) protein, a cholesterol transporter located in the apical membrane of enterocytes. Synonyms: (3R,4R,5R)-3-(4-fluorophenyl)-5-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-((S)-2-hydroxy-1-phenylethyl)-4-(4-hydroxyphenyl)piperidine-2,6-dione. Grade: > 95%. Molecular formula: C33H30F2N2OS. Mole weight: 572.61. | |
| EZH2-IN-5 | EZH2-IN-5 is a potent inhibitor of EZH2 with IC50s of 1.52 and 4.07 nM for wild-type and mutant Tyr641 EZH2, respectively. Synonyms: Benzamide, 5-bromo-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-[[trans-4-(dimethylamino)cyclohexyl]ethylamino]-2-methyl-. CAS No. 1403258-69-4. Molecular formula: C26H37BrN4O2. Mole weight: 517.50. | |
| EZH2-IN-6 | EZH2-IN-6, an inhibitor of EZH2, has enhanced antitumor activity. Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxamide, 1-[(1R)-1-[trans-4-[3-(cyclopropyloxy)-1-azetidinyl]cyclohexyl]ethyl]-N-[[1,2-dihydro-6-methyl-4-(methylthio)-2-oxo-3-pyridinyl]methyl]-2-methyl-. CAS No. 2702269-27-8. Molecular formula: C31H41N5O3S. Mole weight: 563.75. | |
| Ezlopitant | Ezlopitant, also known as CJ-11,974, is a NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Synonyms: CJ 11,974; CJ-11974; CJ11974; (7S,8S)-7-[di(phenyl)methyl]-N-[(2-methoxy-5-propan-2-ylphenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine. CAS No. 147116-64-1. Molecular formula: C31H38N2O. Mole weight: 454.66. | |
| EZM0414 | EZM0414 is a first-in-class and oral SETD2 inhibitor, which is under research for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). Synonyms: EZM0414; 2411748-50-8; KCY37T9RXU; EZM-0414; UNII-KCY37T9RXU; N-[(1R,3S)-3-(4-acetylpiperazin-1-yl)cyclohexyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide; 1H-Indole-2-carboxamide, N-((1R,3S)-3-(4-acetyl-1-piperazinyl)cyclohexyl)-4-fluoro-7-methyl-; N-((1R,3S)-3-(4-Acetylpiperazin-1-yl)cyclohexyl)-4-fluoro-7-methyl-1H-indole-2-carboxamide; CHEMBL5095235; SCHEMBL21739955; GLXC-25885; BDBM50594406; NSC841441; AKOS040760023; AT34570; NSC-841441; MS-26809; CS-0435622; KS6. Molecular formula: C22H29FN4O2. Mole weight: 400.49. | |
| EZM2302 | EZM2302 is an inhibitor of CARM1 enzymatic activity in biochemical assays (IC50?=?6?nM) with broad selectivity against other histone methyltransferases. Synonyms: EZM 2302; EZM-2302; methyl (R)-2-(2-(2-chloro-5-(2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate. Grade: >98%. CAS No. 1628830-21-6. Molecular formula: C29H37ClN6O5. Mole weight: 585.1. | |
| Ezurpimtrostat | Ezurpimtrostat is a palmitoyl protein thioesterase 1 (PPT-1) inhibitor. Synonyms: 4-(4-(tert-butylamino)piperidin-1-yl)-N-(4-chlorobenzyl)quinolin-2-amine. CAS No. 1914148-72-3. Molecular formula: C25H31ClN4. Mole weight: 423.00. | |
| Ezutromid | Ezutromid, also known as BMN-195 and SMTC-1100, is an orally bioavailable and non-toxic small molecule that transcriptionally upregulates the utrophin gene (EC50= 0.4 uM), increasing both utrophin mRNA and protein. It significantly reduces dystrophin-deficient muscle pathology in vivo. Synonyms: 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole; BMN-195; BMN 195; BMN195; SMTC-1100; SMTC1100; SMTC 1100; VOX-C1100; Ezutromid. CAS No. 945531-77-1. Molecular formula: C19H15NO3S. Mole weight: 337.39. | |
| F-1 | F-1 is a potent ALK and ROS1 dual inhibitor. It suppresses phospho-ALK and its relative downstream signaling pathways, with IC50s of 2.1 nM, 2.3 nM, 1.3 nM and 3.9 nM for ALKWT, ROS1WT, ALKL1196M and ALKG1202R, respectively. Grade: 98%. CAS No. 2244775-31-1. Molecular formula: C22H27ClN8O3S. Mole weight: 519.02. | |
| F1063-0967 | F1063-0967 is an inhibitor of dual-specificity phosphatase 26 (DUSP26) with IC50 of 11.62 μM. Synonyms: (Z)-2-hydroxy-4-(6-(5-(4-methylbenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)hexanamido)benzoic acid. CAS No. 613225-56-2. Molecular formula: C24H24N2O5S2. Mole weight: 484.59. | |
| FA2BG1 Glycan, 2-AA labelled | FA2BG1 Glycan, 2-AA labelled is a biomedical research compound used in glycomics studies. It's particularly useful in the analysis and detection of diseases such as cancer and autoimmune disorders where abnormal glycosylation patterns are often observed. Synonyms: FA2BG1 N-linked oligosaccharide; FA2G1 with bisecting GlcNAc; G1F with bisecting GlcNAc. | |
| FA2BG1 Glycan, 2-AB labelled | FA2BG1 Glycan, 2-AB labelled, a crucial biomolecule with broad implications in the diagnosis and treatment of myriads of cancer types, beckons attention due to its capability as a diagnostic tool to detect alterations in cell surface glycosylation and track cancer treatment's efficacy. Synonyms: FA2BG1 N-linked oligosaccharide, 2-AB labelled; FA2G1 with bisecting GlcNAc, 2-AB labelled; G1F with bisecting GlcNAc, 2-AB labelled. | |
| FA2B Glycan, 2-AA labelled | FA2B Glycan, 2-AA labelled is a prodigious compound, serving as an indispensable instrument for studying and comprehending intricate glycan structures. Renowned and heavily employed in the realm of glycobiology research, this remarkable product unfailingly facilitates an exhaustive exploration of glycosylation processes, as well as an in-depth analysis of the multifaceted interactions between glycans and proteins. | |
| FA2B Glycan, 2-AB labelled | FA2B Glycan, 2-AB labelled. | |
| FA2B N-Glycan | FA2B N-Glycan is a naturally occurring glycan presenting on N-linked glycoproteins. It exhibits pivotal significance in numerous cellular phenomena such as cell adhesion, signaling and immune response. It can be used to study glycosylation patterns and glycan functionality. Synonyms: Asialo, agalacto, core-fucosylated, bisected, bi-antennary N-linked glycan. Mole weight: 1667. | |
| FA2G1 N-Glycan | FA2G1 N-Glycan is a compound assuming a paramount role in the comprehensive exploration and comprehension of glycoproteins alongside their intricate functionalities. With its widespread employment as a research tool, this N-glycan holds the potential for the profound investigation of diverse maladies encompassing cancer, inflammation and hereditary disorders. Synonyms: Asialo, core fucosylated, bi-antennary N-linked glycan; NA2G1F N-Glycan. CAS No. 721918-59-8. Molecular formula: C62H104N4O45. Mole weight: 1625.49. | |
| FAAH-IN-1 | FAAH-IN-1 is a fatty acid amide hydrolase (FAAH) inhibitor, with IC50s of 145 nM and 650 nM for rat and human FAAH, respectively. Synonyms: FAAH-IN-1; CHEMBL2386560; SCHEMBL2681198; JCDQNWAFZWEYBZ-CVEARBPZSA-N; BDBM50434324; AKOS040733139; HY-111389; CS-0040311; (1S,2S)-2-(4-{5-[(5-Chloropyridin-2-yl)thio]-1H-imidazol-4-yl}phenyl)-N,N-dimethylcyclopropanecarboxamide; 1242441-47-9. CAS No. 1242441-47-9. Molecular formula: C20H19ClN4OS. Mole weight: 398.91. | |
| FAAH inhibitor 1 | Time-dependent preincubation study of FAAH inhibitor 1 was consistent with it being a reversible inhibitor. Activity-based protein-profiling (ABPP) evaluation of FAAH inhibitors 1 in rat tissues revealed that it had exceptional selectivity and no off-target activity with respect to other serine hydrolases. Molecular shape overlay of FAAH inhibitor 1 with a known FAAH inhibitor indicated that these compounds might act as transitionstate analogues, forming putative hydrogen bonds with catalytic residues and mimicking the charge distribution of the tetrahedral transition state. FAAH inhibitors 1 was exclusively specific against FAAH in rat brain and had no missing protein bands in all the other tissues that were tested. Synonyms: FAAH inhibitor 1. Grade: >98%. CAS No. 326866-17-5. Molecular formula: C24H23N3O3S3. Mole weight: 497.65. | |
| Fabesetron | Fabesetron is an orally active 5-HT3 receptor antagonist with 5-HT4 receptor antagonistic activity. Fabesetron can be used in the study for both acute and delayed emesis induced by cancer chemotherapy. Synonyms: (+)-(R)-8,9-Dihydro-10-methyl-7-((5-methylimidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one; Pyrido[1,2-a]indol-6(7H)-one, 8,9-dihydro-10-methyl-7-[(4-methyl-1H-imidazol-5-yl)methyl]-, (7R)-; FK1052; FK-1052. CAS No. 129300-27-2. Molecular formula: C18H19N3O. Mole weight: 293.36. | |
| Fabp4/5-IN-2 | Fabp4/5-IN-2 is a Fabp4/5 inhibitor. Grade: >98%. CAS No. 1227413-92-4. Molecular formula: C19H15ClN4O2. Mole weight: 366.81. | |
| Facinicline | Facinicline is a partial agonist of the nicotinic alpha-7 (α7) receptor. It is used for the oral treatment of Alzheimer's. It was being co-developed by Roche and was in clinic phase 2 trials with no progress. Uses: Facinicline is used for the oral treatment of alzheimer's. Synonyms: Facinicline; RG-3487; MEM-3454; R-3487; RO-5313534; RG3487; MEM3454; R-487; RO5313534; RG 3487; MEM 3454; R 3487; RO 5313534; (S)-N-(quinuclidin-3-yl)-1H-indazole-3-carboxamide; N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-1H-indazole-3-carboxamide. Grade: 98%. CAS No. 677306-35-3. Molecular formula: C15H18N4O. Mole weight: 270.34. | |
| Factor B-IN-1 | Factor B-IN-1 is an inhibitor of Factor B. (Extracted from patent WO2013164802A1, Example 24). Synonyms: 1H-Benzimidazole-6-carbonitrile, 2-[hydroxy(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-; 2-[Hydroxy-(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-1H-benzimidazole-6-carbonitrile; 2-[hydroxy(5-methoxy-7-methyl-1H-indol-4-yl)methyl]-1H-1,3-benzodiazole-6-carbonitrile. Grade: ≥95%. CAS No. 1481631-75-7. Molecular formula: C19H16N4O2. Mole weight: 332.36. | |
| Factor D inhibitor 6 | Factor D inhibitor 6 is a potent, highly selective and orally active inhibitor of factor D (FD) with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases. Synonyms: 1-{2-[(1R,3S,5R)-3-{[(1R)-1-(3-Chloro-2-fluorophenyl)ethyl]carbamoyl}-2-azabicyclo[3.1.0]hex-2-yl]-2-oxoethyl}-1H-pyrazolo[3,4-c]pyridine-3-carboxamide; 2-Azabicyclo[3.1.0]hexane-3-carboxamide, 2-[2-[3-(aminocarbonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl]acetyl]-N-[(1R)-1-(3-chloro-2-fluorophenyl)ethyl]-, (1R,3S,5R)-. Grade: ≥95%. CAS No. 1386455-51-1. Molecular formula: C23H22ClFN6O3. Mole weight: 484.91. | |
| FadD32 Inhibitor-1 | FadD32 inhibitor-1 has anti-tuberculosis activity and is an effective FadD32 inhibitor. CAS No. 2081969-24-4. Molecular formula: C24H20ClN3O. Mole weight: 401.89. | |
| FAD disodium salt | FAD disodium salt is the salt form of FAD, which is a coenzyme that facilitates the transfer of electrons by flavoenzymes in oxidation-reduction reactions in cells. Nutritional supplement in health care products. Uses: Ingredient of health care products. Synonyms: Riboflavin 5'-(trihydrogen diphosphate), P'→5'-ester with adenosine, sodium salt (1:2); Riboflavin 5'-(trihydrogen diphosphate), P'→5'-ester with adenosine, disodium salt; FAD sodium salt; Flavin adenine dinucleotide sodium salt. CAS No. 84366-81-4. Molecular formula: C27H31N9Na2O15P2. Mole weight: 829.52. | |
| Fadolmidine HCl | Fadolmidine Hydrochloride, is a novel α2-adrenoceptor (α2-AR) agonist, having antinociception properties. It can be used for the control of inflammatory, postoperative and neuropathic pain. Synonyms: Fadolmidine HCl; MPV-2426; MPV 2426; MPV2426; 3-((1H-imidazol-4-yl)methyl)-2,3-dihydro-1H-inden-5-ol hydrochloride. Grade: 97%. CAS No. 189353-32-0. Molecular formula: C13H15ClN2O. Mole weight: 250.72. | |
| Fadrozole | Fadrozole is a potent and selective inhibitor of aromatase with IC50 of 4.5 nM. Uses: Antineoplastic agents, hormonal. Synonyms: Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-; CGS 16949A (free base); 5-p-cyanophenyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyridine; 4-{5H,6H,7H,8H-imidazo[1,5-a]pyridin-5-yl}benzonitrile. Grade: 95%. CAS No. 102676-47-1. Molecular formula: C14H13N3. Mole weight: 223.27. | |
| Fadrozole Hydrochloride | Fadrozole (INN, marketed as Afema by Novartis) is an aromatase inhibitor that has been introduced in Japan for the treatment of breast cancer. Synonyms: Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, hydrochloride (1:1); Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)-, monohydrochloride; Afema; CGS 16949; CGS 16949A. Grade: 99%. CAS No. 102676-31-3. Molecular formula: C14H14ClN3. Mole weight: 259.73. | |
| Fagomine | Fagomine is a captivating natural alkaloid compound showcasing its exceptional attributes in studying diabetes and viral infections. Synonyms: D-Fagomine. CAS No. 53185-12-9. Molecular formula: C6H13NO3. Mole weight: 147.17. | |
| Faicar | FAICAR is the derivative of AICAR, which is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia. Cardioprotective. Synonyms: 5-Formylamino-4-imidazolecarboxamide Ribonucleotide; 5-(Formylamino)-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 5-Formamido-1-β-D-ribofuranosyl-,5'-(dihydrogen phosphate)-imidazole-4-carboxamide. Grade: 85%. CAS No. 13018-54-7. Molecular formula: C10H15N4O9P. Mole weight: 366.22. | |
| FAK-IN-1 | FAK-IN-1 is an inhibitor of FAK with anticancer activities. (Extracted from patent WO2020231726, Example 27). Synonyms: 10H-Pyrimido[5,4-b]thiazolo[5,4-e][1,4]diazepin-10-one, 4,9-dihydro-2,4,9-trimethyl-6-[(1,2,3,4-tetrahydro-6-methoxy-2-methyl-7-isoquinolinyl)amino]-, 2,2,2-trifluoroacetate (1:1). CAS No. 2553215-22-6. Molecular formula: C24H26F3N7O4S. Mole weight: 565.57. | |
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