BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| Bevantolol Hydrochloride | Bevantolol is a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension. Synonyms: 2-Propanol,1-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-,hydrochloride; 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol Hydrochloride. Grades: ≥95%. CAS No. 42864-78-8. Molecular formula: C20H28ClNO4. Mole weight: 381.89. |  |
| Bexarotene Acyl Glucuronide | Bexarotene Acyl Glucuronide is a glucuronide metabolite of Bexarotene. Synonyms: Bexarotene Acyl-β-D-glucuronide; 1-[4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentaMethyl-2-naphthalenyl)ethenyl]benzoate] β-D-Glucopyranuronic Acid. Grades: > 95%. CAS No. 198700-33-3. Molecular formula: C30H36O8. Mole weight: 524.62. | |
| BF 2649 | Pitolisant hydrochloride is an antagonist of the histamine H3 receptor, which is used for the treatment of narcolepsy with or without cataplexy in adult patients. Uses: The treatment of narcolepsy with or without cataplexy. Synonyms: BF 2649; BF2649; BF-2649; pitolisant hydrochloride; Wakix; 1-[3-[3- (4-chlorophenyl) propoxy]propyl]piperidine hydrochloride. CAS No. 903576-44-3. Molecular formula: C17H27Cl2NO. Mole weight: 332.309. | |
| BI-3406 | BI-3406 is a potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS, and mutants of RAS are major oncogenes and occur in many human cancers. Inhibition of SOS1 in a mutant KRAS cell line can suppress tumor growth. Synonyms: BI 3406; BI3406. CAS No. 2230836-55-0. Molecular formula: C23H25F3N4O3. Mole weight: 462.5. | |
| BI-847325 | BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Synonyms: BI-847325; BI 847325; BI847325. Grades: 98%. CAS No. 1207293-36-4. Molecular formula: C29H28N4O2. Mole weight: 464.56. | |
| Bictegravir | Bictegravir is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM for strand transfer activity. Bictegravir is a drug of the integrase inhibitor class that was copied from Dolutegravir by scientists at Gilead Sciences. Bictegravir also inhibits HIV-1 viral infection in MT-2 and MT-4 cells, CD4+ T cells, and macrophages (EC50s = 1.5, 2.5, 1.5, and 6.6 nM, respectively) without exhibiting cytotoxicity (CC50s = 10.3, 3.7, 13, and 29.8 μM, respectively). In 2016, bictegravir was in a Phase 3 trial as part of a single tablet regimen in combination with tenofovir alafenamide (TAF) and emtricitabine (FTC) for the treatment of HIV-1 infection. Synonyms: GS-9883; GS 9883; GS9883. Grades: ≥98%. CAS No. 1611493-60-7. Molecular formula: C21H18F3N3O5. Mole weight: 449.39. | |
| Bictegravir sodium | Bictegravir sodium is a HIV-1 integrase strand transfer inhibitor that is derived from the drug dolutegravir. Synonyms: Bictegravir sodium|1807988-02-8|Bictegravir (sodium)|UNII-4L5MP1Y7W7|4L5MP1Y7W7|sodium;(1S, 11R, 13R)-3, 6-dioxo-7-[(2, 4, 6-trifluorophenyl)methylcarbamoyl]-12-oxa-2, 9-diazatetracyclo[11.2.1.02, 11.04, 9]hexadeca-4, 7-dien-5-olate|Bictegravir sodium [USAN]|Bictegravir sodium (JAN / USAN) |CHEMBL3989867|SCHEMBL 19991461|CHEBI: 172961|BCP20910|HY-17605A|AC-30681|CS-0380750|D10910|N16970|A904622|Q27259 952|GS-9883; GS 9883; GS9883; GS-9883-01; GS9883-01; GS 9883-01|(2R,5S,13aR)-8-Hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide monosodium salt|2,5-Methanopyrido(1',2':4,5)pyrazino(2,1-b)(1,3)oxazepine-10-carboxamide, 2,3,4,5,7,9,13,13a-octahydro-8-hydroxy-7,9-dioxo-N-((2,4,6-trifluorophenyl)methyl)-, sodium salt (1:1), (2R,5S,13aR)-|Sodium (2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1, 3]oxazepin-8-olate|sodium (2R,5S,13aR)-7,9-dioxo-10-[(2,4,6-trifluorobenzyl)carbamoyl]-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate. Grades: >98%. CAS No. 1807988-02-8. Molecular formula: C21H17F3N3NaO5. Mole weight: 471.4. | |
| Binimetinib | Binimetinib is an oral, highly selective MEK inhibitor. Synonyms: MEK162; MEK-162; MEK 162; ARRY162; ARRY-162; ARRY 162; ARRY438162, Binimetinib; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide. Grades: >98%. CAS No. 606143-89-9. Molecular formula: C17H15BrF2N4O3. Mole weight: 441.233. | |
| Birinapant | Birinapant, also known as TL32711, is a synthetic small molecule and peptido mimetic of second mitochondrial-derived activator of caspases (SMAC) and inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins, with potential antineoplastic activity. As a SMAC mimetic and IAP antagonist, TL32711 binds to and inhibits the activity of IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TL-32711; TL32711; TL 32711. Birinapant. Grades: >99.50%. CAS No. 1260251-31-7. Molecular formula: C42H56F2N8O6. Mole weight: 806.957. | |
| bis(2-(7-methoxynaphthalen-1-yl)ethyl)amine | bis(2-(7-methoxynaphthalen-1-yl)ethyl)amine is an impurity of agomelatine, an atypical antidepressant used to treat major depressive disorder. Synonyms: 2-(7-Methoxy-1-naphthyl)-N-[2-(7-methoxy-1-naphthyl)ethyl]ethanamine; 7-Methoxy-N-[2-(7-methoxy-1-naphthalenyl)ethyl]-1-naphthaleneethanamine. CAS No. 1385018-57-4. Molecular formula: C26H27NO2. Mole weight: 385.5. | |
| bis(2-cyanoethyl)4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate | bis(2-cyanoethyl)4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate is an impurity of clevidipine, a dihydropyridine calcium channel blocker used as an oral antihypertensive drug. Synonyms: Bis(2-cyanoethyl)4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate. CAS No. 175688-79-6. Molecular formula: C21H19Cl2N3O4. Mole weight: 448.30. | |
| Bis(2-?(dimethylamino)?ethyl) Succinate | Cas No. 19249-04-8. | |
| Bis(4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)methanone | Bis(4-(8-chloro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(6H)-ylidene)piperidin-1-yl)methanone is an impurity of Desloratadine, which is a tricyclic H1 inverse agonist used to treat allergies. Synonyms: Bis[4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]methanone; Methanone, bis[4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinyl]-. Molecular formula: C39H36Cl2N4O. Mole weight: 647.63. | |
| Bis(4-nitrobenzyl) Oxacillin Penillic Acid | Bis(4-nitrobenzyl) Oxacillin Penillic Acid is an intermediate in the synthesis of Oxacillin, which is used as an antibiotic related to Penicillin. Molecular formula: C33H29N5O9S. Mole weight: 671.68. | |
| Bis-5,6'-[N-(HABA-CBz)] Kanamycin A | Bis-5,6'-[N-(HABA-CBz)] Kanamycin A is an intermediate of Amikacin. Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Molecular formula: C42H62N6O19. Mole weight: 954.97. | |
| bis(6-(((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methoxy)benzo[d][1,3]dioxol-5-yl)methane | An impurity of Paroxetine which is a selective serotonin reuptake inhibitor. Synonyms: Paroxetine Impurity 30; 3,3'-(Methylenebis(1,3-benzodioxole-6,5-diyloxymethylene))bis((3S,4R)-4-(4-fluorophenyl)piperidine). Grades: >95%. CAS No. 2105932-71-4. Molecular formula: C39H40F2N2O6. Mole weight: 670.74. | |
| Bis-clindamycinyl-(2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran) Phosphate | Bis-clindamycinyl-(2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran) Phosphate is an impurity of Clindamycin, which is a semi-synthetic antibiotic with high bioavailability prepared from Lincomycin. Synonyms: Bis[(3aS,4R,6R,7R,7aS)-4-[(1S,2S)-2-chloro-1-({[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl}amino)propyl]-2,2-dimethyl-6-(methylsulfanyl)tetrahydro-4H-[1,3]dioxolo[4,5-c]pyran-7-yl] hydrogen phosphate. Molecular formula: C42H73Cl2N4O12PS2. Mole weight: 992.06. | |
| Bisdemethoxycurcumin | Bisdemethoxycurcumin is one of the three major forms of curcuminoids found in the rhizomes of turmeric. Bisdemethoxycurcumin displays antioxidant, anti-inflammatory as well as chemotherapeutic activity. Bisdemethoxycurcumin acts as an inhibitor of human pancreatic α-amylase, a target for type-2 diabetes. Synonyms: Curcumin III; Didemethoxycurcumin; 1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxyphenyl)-, (1E,6E)-; (1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; 1,6-Heptadiene-3,5-dione, 1,7-bis(p-hydroxyphenyl)-, (E,E)-; (1E,6E)-Bis(demethoxy)curcumin; Bisdesmethoxycurcumin; (E,E)-Bisdemethoxycurcumin. Grades: ≥95%. CAS No. 33171-05-0. Molecular formula: C19H16O4. Mole weight: 308.33. | |
| Bis(L-Valine) Ester Ganciclovir Trifluoroacetic Acid Salt | Bis(L-Valine) Ester Ganciclovir Trifluoroacetic Acid Salt is an impurity of Ganciclovir. Ganciclovir is a nucleoside analog structurally related to Acyclovir. Ganciclovir is an antiviral. Synonyms: L-Valine, 2-[(2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-1,3-propanediyl Ester Trifluoroacetic Acid Salt; Ganciclovir Impurity F Trifluoroacetic Acid Salt. Grades: 98%. Molecular formula: C19H31N7O6.x(C2HF3O2). Mole weight: 453.49 + x(114.02). | |
| BIS THF HNS Derivative 1 | 1-[[[[(3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione is an impurity of TMC114, a bis-THF-derived compound that acts as an HIV-aspartyl protease inhibitor. Synonyms: 1-[[[[(3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione. Grades: > 95%. CAS No. 253265-98-4. Molecular formula: C11H13NO7. Mole weight: 271.22. | |
| BIS THF HNS Derivative 2 | 1-[[[[(3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione is an impurity of TMC114, a bis-THF-derived compound that acts as an HIV-aspartyl protease inhibitor. Synonyms: 1-[[[[(3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl]oxy]carbonyl]oxy]-2,5-pyrrolidinedione. Grades: > 95%. CAS No. 799241-85-3. Molecular formula: C11H13NO7. Mole weight: 271.22. | |
| BIS THF HNS Derivative 3 | Grades: > 95%. CAS No. 799241-86-4. Molecular formula: C11H13NO7. Mole weight: 271.22. | |
| BIS THF Nitro Derivative 1 | (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl ester carbonic acid is an impurity of bis-THF-derived compounds (such as [1-benzyl-2-hydroxy-3-(arylsulfonamido)propyl]carbamates) that act as HIV-aspartyl protease inhibitors. Synonyms: (3S,3aR,6aS)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid. Grades: > 95%. CAS No. 288296-64-0. Molecular formula: C13H13NO7. Mole weight: 295.24. | |
| BIS THF Nitro Derivative 2 | (3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl 4-nitrophenyl ester carbonic acid is an impurity of bis-THF-derived compounds (such as [1-benzyl-2-hydroxy-3-(arylsulfonamido)propyl]carbamates) that act as HIV-aspartyl protease inhibitors. Synonyms: (3S,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl 4-Nitrophenyl Ester Carbonic Acid. Grades: > 95%. CAS No. 252873-01-1. Molecular formula: C13H13NO7. Mole weight: 295.24. | |
| Bis(tributylammonium) pyrophosphate | Synonyms: Diphosphoric acid, compd. with N,N-dibutyl-1-butanamine (1:2); Tributylamine, pyrophosphate (2:1); Tributylamine, pyrophosphate; Pyrophosphoric acid, compd. with tributylamine (1:2); 1-Butanamine, N,N-dibutyl-, (diphosphate) (2:1); Bis(tri-n-butylammonium) pyrophosphate. CAS No. 5975-18-8. Molecular formula: C24H58N2O7P2. Mole weight: 548.67. | |
| Bis Valacyclovir | An impurity of Valacyclovir. Synonyms: Valacyclovir Impurity P (EP), Bis-valaciclovir in USP monograph (impurity K). Grades: > 95%. CAS No. 1356019-51-6. Molecular formula: C14H18N10O4. Mole weight: 390.36. | |
| BKM120 | BKM120, also called as buparlisib or NVP-BKM120, activity in a range of preclinical cancer models, specifically inhibits class I PI3K isoforms, which blocks p110α (IC50 = 52 nM), p110β (IC50 = 166 nM), p110δ (IC50 = 116 nM) and p110γ (IC50 = 262 nM). BKM120 displays little sensitive to Class III and Class IV PI3K's or PI4K. Synonyms: 5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; BKM120; buparlisib; NVP-BKM120; 944396-07-0; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; 944396-07-0; NVP-BKM120; Buparlisib; 5-(2,6-dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine; NVP-BKM-120; BKM120; BKM 120; BKM-120; UNII-0ZM2Z182GD; 1202777-78-3; CHEMBL2017974; CHEBI:71954; 5-[2,6-Di(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; 5-[2,6-Di(Morpholin-4-Yl)pyrimidin-4-Yl]-4-(Trifluoromethyl)pyridin-2-Amine; C18H21F3N6O2; BKM120, BKM-120|; 2-Pyridinamine,5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-; 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-Pyridinamine. CAS No. 944396-07-0. Molecular formula: C18H21F3N6O2. Mole weight: 410.39. | |
| BL-918 | BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1). It induces cytoprotective autophagy for Parkinson's disease treatment. It protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD. Synonyms: BL 918; BL918; (R)-2- (3- (3, 5-bis (trifluoromethyl)phenyl)thioureido)-N- (2, 4-difluorophenyl)-2-phenylacetamide. Grades: ≥98%. CAS No. 2101517-69-3. Molecular formula: C23H15F8N3OS. Mole weight: 533.4. | |
| BLU-667 | BLU-667 (Pralsetinib) is a highly effective and selective RET inhibitor. It has an IC50 of 0.3-0.4 nM for the fusion of WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET. Synonyms: Pralsetinib. Grades: ≥98% by HPLC. CAS No. 2097132-94-8. Molecular formula: C27H32FN9O2. Mole weight: 533.6. | |
| BLZ945 | BLZ945 is an orally active, potent and selective CSF-1R inhibitor, which inhibits CSF-1R activity with an IC50 of 1nM and is more than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and Platelet-derived Growth Factor Receptor beta (PDGFRb). Synonyms: sotuletinib; BLZ 945; BLZ-945. Grades: >98%. CAS No. 953769-46-5. Molecular formula: C20H22N4O3S. Mole weight: 398.48. | |
| BML-277 | BML-277 is a selective APT-competitive inhibitor of the DNA damage response signaling enzyme CHK2 ( IC50 =15 nM). Uses: A selective apt-competitive inhibitor. Synonyms: BML-277; BML 277; BML277; Chk2 Inhibitor II;2-[4-(4-chlorophenoxy)phenyl]-3H-benzimidazole-5-carboxamide. Grades: ≥98%. CAS No. 516480-79-8. Molecular formula: C20H14ClN3O2. Mole weight: 363.80. | |
| BMS 195614 | BMS 195614 is a neutral RARα selective antagonist (Ki = 2.5 nM) and exhibits no significant effect on nuclear receptor corepressor (NCoR) binding. BMS 195614 moderately decreases SMRT binding to RAR and agonist-induced coactivator (CoA) recruitment. Synonyms: 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid; 4-({[5,5-Dimethyl-8-(3-quinolinyl)-5,6-dihydro-2-naphthalenyl]carbonyl}amino)benzoic acid; Benzoic acid, 4-[[[5,6-dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]-; BMS 614. Grades: ≥98% by HPLC. CAS No. 253310-42-8. Molecular formula: C29H24N2O3. Mole weight: 448.51. | |
| BMS 493 | BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist. Synonyms: 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(phenylethynyl)-2-naphthalenyl]ethenyl]-benzoic Acid; BMS-493; BMS493; (E)-4-[2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)naphthalen-2-yl]ethen-1-yl]benzoic acid; Benzoic acid, 4-[(1E)-2-[5,6-dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]-. Grades: 97%. CAS No. 215030-90-3. Molecular formula: C29H24O2. Mole weight: 404.50. | |
| BMS-663068 | BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. Synonyms: Fostemsavir; BMS-663068; BMS 663068; BMS663068. Grades: >98%. CAS No. 864953-29-7. Molecular formula: C25H26N7O8P. Mole weight: 583.49. | |
| BMS-777607 | BMS-777607 is a novel prodrug of the dual Met/VEGFR-2 inhibitor. It shows antitumor activity, inducing apoptosis and decreasing proliferation and migration. Synonyms: BMS817378; BMS 817378; BMS-817378; BMS 777607; BMS777607; ASLAN 002; ASLAN-002; ASLAN002. CAS No. 1025720-94-8. Molecular formula: C25H19ClF2N4O4. Mole weight: 512.893. | |
| BMS-779788 | BMS-779788 is a LXR partial agonist with IC50 values of 68 nM and 14 nM for LXRα and LXRβ respectively. BMS-779788 induces LXR target genes in blood in vivo with EC50 value of 610 nM, and significantly increases plasma triglyceride and LDL cholesterol. Synonyms: BMS-779788; BMS 779788; BMS779788; BMS-788; BMS 788; BMS788; XL-652; XL652; XL652; EXEL 04286652; EXEL04286652; EXEL-04286652;; 2-[2-[2-(2-chlorophenyl)propan-2-yl]-1-[4-(3-methylsulfonylphenyl)phenyl]imidazol-4-yl]propan-2-ol. CAS No. 918348-67-1. Molecular formula: C28H29ClN2O3S. Mole weight: 509.061. | |
| BMS-791325 HCl | BMS-791325 HCl is an allosteric inhibitor that binds to thumb site 1 of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase. BMS-791325 inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 at 50% inhibitory concentrations (IC50 < 28 nM). In cell culture, BMS-791325 inhibited replication of HCV subgenomic replicons representing genotypes 1a and 1b at 50% effective concentrations (EC50s) of 3 nM and 6 nM, respectively, with similar (3 to 18 nM) values for genotypes 3a, 4a, and 5a. BMS-791325 was found to have distinguishing antiviral, safety, and pharmacokinetic properties that resulted in its selection for clinical evaluation. BMS-791325 is currently under Phase III trials. Synonyms: Beclabuvir hydrochloride; BMS-791325 HCl; BMS 791325 HCl; BMS791325 HCl. Grades:> 98%. CAS No. 958002-36-3. Molecular formula: C36H46ClN5O5S. Mole weight: 696.304. | |
| BMS-794833 | BMS-794833 is a potent ATP competitive inhibitor of Met/VEGFR2 with IC50 of 1.7 nM/15 nM. Synonyms: BMS794833; BMS 794833. Grades: 0.98. CAS No. 1174046-72-0. Molecular formula: C23H15ClF2N4O3. Mole weight: 468.845. | |
| BMS 961 | BMS 961 is a potent and selective retinoic acid receptor gamma (RARγ) agonist with an IC50 value of 30 nM. Synonyms: BMS961; BMS-961; 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid; Benzoic acid, 3-fluoro-4-[[2-hydroxy-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)acetyl]amino]-. Grades: ≥97% by HPLC. CAS No. 185629-22-5. Molecular formula: C23H26FNO4. Mole weight: 399.45. | |
| BMS 986020 | BMS 986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist with an IC50 value less than 300 nM for human LPA1 expressing CHO cells. It inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS 986020 is used for the treatment of idiopathic pulmonary fibrosis (IPF). Synonyms: BMS-986020; BMS986020. Grades: ≥98%. CAS No. 1257213-50-5. Molecular formula: C29H26N2O5. Mole weight: 482.5. | |
| BMS-986120 | BMS-986120, an imidazoles derivative, has been found to be a PAR4 antagonist that could probably be effective against thrombus propagation and pathological vascular occlusion. It was just completed a Phase I trail in in Thrombosis. Synonyms: BMS-986120; BMS 986120; BMS986120; 4-(4-(((6-methoxy-2-(2-methoxyimidazo[2,1-b][1,3,4]thiadiazol-6-yl)benzofuran-4-yl)oxy)methyl)-5-methylthiazol-2-yl)morpholine. Grades: 98%. CAS No. 1478712-37-6. Molecular formula: C23H23N5O5S2. Mole weight: 513.59. | |
| BMS-986141 | BMS-986141 is a potential medication under the clinical trial that evaluates the pharmacokinetics of BMS-986141 in participants with hepatic impairment compared to healthy participants. Synonyms: Unii-W530irz40G. CAS No. 1478711-48-6. Molecular formula: C27H23N5O5S2. Mole weight: 561.6. | |
| Bombesin | Bombesin is a neuropeptide with many biological effects such as hormone release, activation of pancreatic enzyme secretion, inhibition of gastric emptying and modulation of gastric acid secretion. It binds to the gastrin-releasing peptide receptor (GRPR) in rat pancreatic acinar cells (Ki = 1.88 nM), and also to frog bombesin receptor subtype 4 (BB4) in CHO cells overexpressing the receptor (Ki = 1.7 nM). Uses: Neurotransmitter agents. Synonyms: H-Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2; L-pyroglutamyl-L-glutaminyl-L-arginyl-L-leucyl-glycyl-L-asparagyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide; Glp-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2. Grades: ≥95%. CAS No. 31362-50-2. Molecular formula: C71H110N24O18S. Mole weight: 1619.85. | |
| Bortezomib Impurity (R,R-Isomer) | Bortezomib Impurity (R,R-Isomer) is a diastereomer of Bortezomib. Synonyms: (1R,2R)-Bortezomib; B-[ (1R) -3-Methyl-1-[[ (2R) -1-oxo-3-phenyl-2-[ (2-pyrazinylcarbonyl) amino]propyl]amino]butyl]boronic Acid; [ (1R) -3-Methyl-1-[[ (2R) -1-oxo-3-phenyl-2-[ (pyrazinylcarbonyl) amino]propyl]amino]butyl]boronic Acid. Grades: 98% by HPLC. CAS No. 1132709-15-9. Molecular formula: C19H25BN4O4. Mole weight: 384.25. | |
| Bortezomib Impurity (R,S-Isomer) | Bortezomib Impurity (R,S-Isomer) is a diastereomer of Bortezomib. Synonyms: (1S,2R)-Bortezomib; B-[ (1S) -3-Methyl-1-[[ (2R) -1-oxo-3-phenyl-2-[ (2-pyrazinylcarbonyl) amino]propyl]amino]butyl]boronic Acid; N-(2-Pyrazinecarbonyl)-D-phenylalanine-D-leucine boronic anhydride. Grades: > 95%. CAS No. 1132709-16-0. Molecular formula: C19H25BN4O4. Mole weight: 384.25. | |
| Bortezomib USP Impurity G | Bortezomib USP Impurity G is an isomer of Bortezomib. It has been demonstrated to inhibit serine proteases shown to lower cellular Aβ concentrations, associated with Alzheimer's or hypertension. Synonyms: (1S,2S)-Bortezomib; ( (S) -3-Methyl-1- ( (S) -3-phenyl-2- (pyrazine-2-carboxamido) propanamido) butyl) boronic acid. Grades: 95%. CAS No. 1132709-14-8. Molecular formula: C19H25BN4O4. Mole weight: 384.243. | |
| Bosentan | Bosentan is an endothelin (ET) receptor antagonist for ET-A and ET-B with Ki of 4.7 nM and 95 nM, respectively. Synonyms: Ro 47-0203. Grades: >98%. CAS No. 147536-97-8. Molecular formula: C27H29N5O6S. Mole weight: 551.61. | |
| Bosentan Impurity D | Bosentan Impurity D is an impurity of Bosentan. Synonyms: O-Deshydroxyethyl Bosentan; N-[1,6-Dihydro-5-(2-methoxyphenoxy)-6-oxo[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide; 4-tert-Butyl-N-[6-hydroxy-5-(2-methoxyphenoxy)-2,2'-bipyrimidin-4-yl]benzenesulfonamide. Grades: > 95%. CAS No. 174227-14-6. Molecular formula: C25H25N5O5S. Mole weight: 507.57. | |
| Bosentan Related Compound 1 | Synonyms: 4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; Bosentan Related Compound D; 4,6-Dichloro-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)pyrimidine; Bosentan Related Compound D USP. Grades: > 95%. CAS No. 150728-13-5. Molecular formula: C15H10Cl2N4O2. Mole weight: 349.18. | |
| Bosentan Related Compound 2 | Bosentan Related Compound 2 is an intermediate as well as a degradation impurity of the endothelin receptor antagonist Bosentan. Synonyms: 4-tert-Butylbenzenesulfonamide; 4-(1,1-Dimethylethyl)benzenesulfonamide; p-tert-butyl-Benzenesulfonamide; NSC 9911. Grades: > 95%. CAS No. 6292-59-7. Molecular formula: C10H15NO2S. Mole weight: 213.30. | |
| Bosentan Related Compound 3 | Bosentan Related Compound 3 is an intermediate of Bosentan. Synonyms: N-[6-Chloro-5-(2-methoxyphenoxy)-(2,2-bipyrimidine)4-4-yl]-(1,1-dimethylethyl)-benzenesulfonamide; 4-tert-Butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzeneSulfonamide. Grades: > 95%. CAS No. 150727-06-3. Molecular formula: C25H24ClN5O4S. Mole weight: 526.02. | |
| Bosentan Related Compound C | Bosentan Related Compound C is an impurity of Bosentan. Synonyms: N,N'-[1,2-Ethanediylbis[oxy[5-(2-methoxyphenoxy)[2,2'-bipyrimidine]-6,4-diyl]]]bis[4-(1,1-dimethylethyl)-benzenesulfonamide; 1,2-Bis({6-[4-(tert-butyl)phenylsulfonamido]-5-(2-methoxyphenoxy)-[2,2'-bipyrimidin]-4-yl}oxy)ethane; Bosentan dimer. Grades: > 95%. CAS No. 1097263-60-9. Molecular formula: C52H52N10O10S2. Mole weight: 1041.18. | |
| BPC 157 | BPC-157 is a synthetic pentadecapeptide. Study shows that BPC-157 is beneficial for the treatment of ulcers in the stomach, intestinal damage such as fistulas and inflammatory disorders, bone and joint healing and growth rates, and organ damage. Synonyms: BPC 157; BPC157; Glycyl-L-α-glutamyl-L-prolyl-L-prolyl-L-prolylglycyl-L-lysyl-L-prolyl-L-alanyl-L-α-aspartyl-L-α-aspartyl-L-alanylglycyl-L-leucyl-L-valine. CAS No. 137525-51-0. Molecular formula: C62H98N16O22. Mole weight: 1419.54. | |
| BQU57 | BQU57, a derivative of RBC8, is a selective GTPase Ral inhibitor relative to the GTPases Ras and RhoA. Synonyms: BQU57; BQU 57; BQU-57. Grades: >98%. CAS No. 1637739-82-2. Molecular formula: C16H13F3N4O. Mole weight: 334.1. | |
| Bretylium Tosylate | Bretylium Tosylate, a class III antiarrhythmic agent, is an inhibitor of the presynaptic release of vasoconstrictive neurotransmitters and a blocker of sympathetic and adrenergic nerves. Synonyms: 2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-Methylbenzenesulfonate; (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate; (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate; ASL 603; Bretylan; Bretylate; Bretylium p-Toluenesulfonate; Bretylium Tosilate; Bretylol; Darenthin; N-Ethyl-N-(o-bromobenzyl)-N,N-dimethylammonium Tosylate; NSC 62164; Ornid. Grades: ≥95%. CAS No. 61-75-6. Molecular formula: C18H24BrNO3S. Mole weight: 414.36. | |
| Brivanib | Brivanib is the hydrolyzed form of Brivanib alaninate, which is a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Synonyms: BMS540215; BMS-540215; BMS 540215. CAS No. 649735-46-6. Molecular formula: C19H19FN4O3. Mole weight: 370.37756. | |
| Brivanib alaninate | Brivanib alaninate is the alaninate ester of a vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with potential antineoplastic activity. Brivanib strongly binds to and inhibits VEGFR2, a tyrosine kinase receptor expressed almost exclusively on vascular endothelial cells; inhibition of VEGFR2 may result in inhibition of tumor angiogenesis, inhibition of tumor cell growth, and tumor regression. Check for active clinical trials or closed clinical trials using this agent. Synonyms: BMS-582664; BMS582664; BMS 582664. CAS No. 649735-63-7. Molecular formula: C22H24FN5O4. Mole weight: 441.45. | |
| BRL 44408 Maleate | BRL 44408 maleate is a selective α2A-adrenoceptor antagonist (Ki = 1.7 nM and 144.5 nM at α2A and α2B-adrenergic receptors, respectively). BRL 44408 increases hippocampal noradrenalin release following systemic administration. Synonyms: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate; 1H-Isoindole, 2-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-, (2Z)-2-butenedioate (1:1). Grades: ≥98% by HPLC. CAS No. 681806-46-2. Molecular formula: C17H21N3O4. Mole weight: 331.37. | |
| Bromodeoxyuridine (BrdU) | 5-Bromo-2'-deoxyuridine (5-BrdU) is a thymidine analog that can be incorporated into newly synthesized DNA to label it. Synonyms: 5-Bromo-2'-deoxyuridine; BrdU; Bromodeoxyuridine; Broxuridine; NSC 38297; 5-Bromo-1-(2-deoxy-beta-D-ribofuranosyl)uracil; 5-bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 5-Bromodeoxyuridine. Grades: ≥98% by HPLC. CAS No. 59-14-3. Molecular formula: C9H11BrN2O5. Mole weight: 307.10. | |
| BS-181 HCl | BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. Synonyms: BS-181 HCl; BS 181 HCl; BS181 HCl. Grades: >98%. CAS No. 1397219-81-6. Molecular formula: C22H32N6.HCl. Mole weight: 416.99. | |
| Bucillamine | Bucillamine is an antirheumatic agent mainly used in Japan and Korea. Synonyms: N-(2-Mercapto-2-methyl-1-oxopropyl)-L-cysteine; N-(2-Mercaptoisobutyryl)cysteine; Rimatil; SA 96; Thiobutarit; Tiobutarit. Grades: 97%. CAS No. 65002-17-7. Molecular formula: C7H13NO3S2. Mole weight: 223.31. | |
| Buclizine hydrochloride | Buclizine hydrochloride is an antihistamine and anticholinergic of the piperazine derivative family. Synonyms: Buclizine dihydrochloride; 1- (4- (tert-Butyl)benzyl)-4- ( (4-chlorophenyl) (phenyl)methyl)piperazine dihydrochloride. Grades: > 98%. CAS No. 129-74-8. Molecular formula: C28H35Cl3N2. Mole weight: 505.952. | |
| Buparvaquone | Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for the therapy and prophylaxis of all forms of theileriosis. It has been shown to have antileishmanial activity in vitro. It can be used to treat bovine East Coast fever protozoa in vitro, along with the only other substance known - Peganum harmala. It is the only really efficient commercial therapy product in bovine theileriosis, where it has been used since the late 1980s. Synonyms: Butalex. Grades: >98%. CAS No. 88426-33-9. Molecular formula: C21H26O3. Mole weight: 326.43. | |
| Bupropion Impurity E | Bupropion Impurity E is a metabolite of Bupropion. Synonyms: 1-(m-Chlorophenyl)-1,2-propanedione; 1-(3'-Chlorophenyl)propane-1,2-dione; 1,2-Propanedione, 1-(3-chlorophenyl)-. Grades: > 95%. CAS No. 10557-17-2. Molecular formula: C9H7ClO2. Mole weight: 182.61. | |
| Bupropion Morpholinol | Bupropion Morpholinol is a major metabolite of the dopamine transport inhibitor and nicotinic antagonist bupropion. It is formed by hydroxylation of bupropion on the tert-butyl group and cyclizes to an acetal. It is a racemic preparation of the R,R-hydroxy bupropion and S,S-hydroxy bupropion isomers. Synonyms: Hydroxy Bupropion, Mixture of Stereoisomers; 2-(3-Chlorophenyl)-3,5,5-triMethyl-; 2-Hydroxy-2-(3'-chlorophenyl)-3,5,5-trimethylmorpholine. Grades: > 95%. CAS No. 357399-43-0. Molecular formula: C13H18ClNO2. Mole weight: 255.75. | |
| Bupropion Related Compound A | Bupropion Related Compound A is a stereoisomer of Bupropion Hydrochloride, a selective inhibitor of dopamine uptake. Synonyms: 3-Deschloro-4-chloro Bupropion Hydrochloride; 2-(tert-Butylamino)-1-(4-chlorophenyl)-1-propanone hydrochloride. Grades: > 95%. CAS No. 1049718-72-0. Molecular formula: C13H19Cl2NO. Mole weight: 276.20. | |
| Bupropion Related Compound C | Bupropion Related Compound C is Bupropion intermediate. It is Bupropion hydrochloride related impurity C. Synonyms: 1-(3-Chlorophenyl)-2-hydroxy-1-propanone. Grades: > 95%. CAS No. 152943-33-4. Molecular formula: C9H9ClO2. Mole weight: 184.62. | |
| Bupropion Related Compound F | Bupropion Related Compound F is Bupropion intermediate. Synonyms: 1-(3-Chlorophenyl)-1-hydroxy-2-propanone; 1-(M-Chlorophenyl)-1-hydroxy-2-propanone. Grades: > 95%. CAS No. 857233-13-7. Molecular formula: C9H9ClO2. Mole weight: 184.62. | |
| butyl 4-methylbenzenesulfonate | Butyl p-Toluenesulfonate (CAS# 778-28-9) is used in preparation of highly-branched chain Ammonium Dicarboxylate Salt. Synonyms: Butyl 4-Toluenesulfonate. CAS No. 778-28-9. Molecular formula: C11H16O3S. Mole weight: 228.31. | |
| BX-795 | 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX795 is a potent and specific PDK1 inhibitor with IC50 of 6 nM, which is 140- and 1600-fold more selective than PKA and PKC. It is also a potent and relatively specific inhibitor of TBK1 with IC50 of 6 nM and IKK? with IC50 of 41 nM. Synonyms: BX 795; BX795. Grades: ≥98%. CAS No. 702675-74-9. Molecular formula: C23H26IN7O2S. Mole weight: 591.47. | |
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