BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| A 410099.1 amide-PEG3-amine-Boc | A 410099.1 amide-PEG3-amine-Boc is a functionalized IAP ligand containing an IAP ligand and a PEG linker of 3 O(CH2)2 units with Boc protected terminal amine, can be used to bind to the target protein ligand. CAS No. 2415256-19-6. Molecular formula: C40H64N6O9. Mole weight: 772.97. |  |
| A 410099.1, amine-Boc hydrochloride | A 410099.1, amine-Boc hydrochloride is an IAP ligand that can be used in the synthesis of PROTAC, whose Boc protected terminal amine support to bind a target protein ligand. CAS No. 2374122-37-7. Molecular formula: C32H50ClN5O5. Mole weight: 620.22. | |
| A41030A | A41030A is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Desulfo-A47394. CAS No. 89139-41-3. Molecular formula: C58H44Cl3N7O18. Mole weight: 1233.36. | |
| A41030B | A41030B is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic L 17392; Teicoplanin aglycone; Antibiotic A 41030B. CAS No. 89139-42-4. Molecular formula: C58H45Cl2N7O18. Mole weight: 1198.92. | |
| A41030C | A41030C is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030C; 7-Demethyl-64-O-demethyl-19-deoxy-11-O-galactosyl-22,31,35-trichlororistomycin A aglycone; Ristomycin A aglycone, 7-demethyl-64-O-demethyl-19-deoxy-11-O-galactosyl-22,31,35-trichloro-. CAS No. 89140-21-6. Molecular formula: C64H54Cl3N7O23. Mole weight: 1395.50. | |
| A41030E | A41030E is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030 E. CAS No. 89139-43-5. Molecular formula: C58H46ClN7O18. Mole weight: 1164.47. | |
| A41030F | A41030F is a glycopeptide antibiotic produced by Streptomyces virginiae A41030. Activity against gram-positive bacteria. Synonyms: Antibiotic A 41030 F. CAS No. 89140-20-5. Molecular formula: C70H64Cl3N7O28. Mole weight: 1557.64. | |
| A 412997 dihydrochloride | A 412997 dihydrochloride is a potent and selective agonist for the dopamine D4 receptor (Ki = 7.9 and 12.1 nM for human D4 and rat D4, receptors) with no activity for other dopamine receptors. Synonyms: A-412997 dihydrochloride; A412997 dihydrochloride; A-412997 dihydrochloride; N-(3-Methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide. Grade: ≥98% by HPLC. CAS No. 1347744-96-0. Molecular formula: C19H23N3O.2HCl. Mole weight: 382.33. | |
| A 419259 | A-419259 is a potent inhibitor of Src family kinases. IC50 values for src, lck, blk, csk, fyn and lyn range between 15 and 50 nM. Synonyms: A419259; A-419259; RK 20449; RK20449; RK-20449. Grade: >98%. CAS No. 364042-47-7. Molecular formula: C29H34N6O. Mole weight: 482.62. | |
| A 419259 trihydrochloride | Potent Hck inhibitor (IC50 = 0.43 nM). Also inhibits other Src family kinases (SFKs). Suppresses proliferation and induces apoptosis in CML cell lines including CD34+. Also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo. Synonyms: A419259 trihydrochloride; A-419259 trihydrochloride; RK 20449 trihydrochloride; RK20449 trihydrochloride; RK-20449 trihydrochloride. Grade: >98%. CAS No. 1435934-25-0. Molecular formula: C29H37Cl3N6O. Mole weight: 592.0. | |
| A 425619 | A 425619 is a potent and selective TRPV1 antagonist (IC50 = 3-9 nM) that inhibits TRPV1 activation by anandamide and N-arachidonoyl-dopamine. A 425619 exhibits an inhibitory effect against inflammatory, postoperative and osteoarthritic in vivo pain models. Uses: Analgesic. Synonyms: A-425619; A 425619; A425619; N-5-Isoquinolinyl-N'-[[(4-(trifluoromethyl)phenyl]methyl]urea. Grade: ≥98% by HPLC. CAS No. 581809-67-8. Molecular formula: C18H14F3N3O. Mole weight: 345.32. | |
| A 437203 | A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. Synonyms: 2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; 2-(3-(4-(2-tert-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1-yl)propylsulfanyl)-3H-pyrimidin-4-one fumarate; A 437203; A-437203; A437203; 1160247-85-7; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base). Grade: >98%. CAS No. 220519-06-2. Molecular formula: C20H27F3N6OS. Mole weight: 456.53. | |
| A 438079 hydrochloride | A 438079 hydrochloride is a competitive P2X7 receptor antagonist with pIC50 value of 6.9 for the inhibition of Ca2+ influx in the human recombinant P2X7 cell line. It protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, but not by inflammasome activation. It partially but significantly prevented the 6-OHDA-induced depletion of striatal DA stores. Synonyms: 3-[[5-(2,3-Dichlorophenyl)-1H-tetrazol-1-yl]methyl]pyridine hydrochloride; A-438079 HCl; A-438079 hydrochloride; A438079 hydrochloride; A 438079 hydrochloride. Grade: >98 %. CAS No. 899507-36-9. Molecular formula: C13H10Cl3N5. Mole weight: 342.61. | |
| A47934 | A47934 is a glycopeptide antibiotic produced by Streptomyces toyocaensis NRRL15009. Activity against gram-positive bacteria. Synonyms: A-47934 Antibiotic; Antibiotic A 47934. CAS No. 90039-80-8. Molecular formula: C58H44Cl3N7O21S. Mole weight: 1313.43. | |
| A 484954 | A 484954 is a eukaryotic elongation factor-2 (eEF-2) kinase inhibitor (IC50 = 0.28 μM in enzymatic assay). A 484954 reduces eEF-2 phosphorylation with little effect on cancer cell growth. Synonyms: A-484954; A 484954; A484954; 7-Amino-1-cyclopropyl-3-ethyl-1,2,3,4-tetrahydro-2,4-dioxopyrido[2,3-d]pyrimidine-6-carboxamide. Grade: ≥98% by HPLC. CAS No. 142557-61-7. Molecular formula: C13H15N5O3. Mole weight: 289.29. | |
| A-51493A | A-51493A is an anthraquinone antibiotic produced by Streptomyces humifer. Activity against gram-positive bacteria. Synonyms: 121245-06-5; A51493A; AC1L52A8; A51493A; A-51493A; PL024209. Grade: >98%. CAS No. 121245-06-5. Molecular formula: C30H31NO10. Mole weight: 565.57. | |
| A-54145A | A metabolite of Argatroban, a medication for the prevention and treatment of thrombosis. Synonyms: Antibiotic A 54145A; A-54145 A. Grade: > 95%. CAS No. 153886-68-1. Molecular formula: C10H13NO3S. Mole weight: 227.28. | |
| A 54556A | A 54556A is an unusual depsipeptide antibiotic produced by the strain of streptomyces hawaiiensis. It can inhibit the growth of 786-O, 769-P and ACHN renal carcinoma cells in MTT assay. A 54556A may be a potential chemotherapeutic agent for treatment of renal carcinoma. It has potent activity against gram-positive and gram-negative bacteria, including MRSA. Synonyms: Antibiotic A 54556A; A 54556 factor A; ADEP 1; Acyldepsipeptide 1; Acyldepsipeptide A; N-[[(2E,4E,6E)-1-Oxo-2,4,6-octatrienyl]-L-Phe-]cyclo[L-Ser*-L-Pro-N-methyl-L-Ala-L-Ala-4beta-methyl-L-Pro-]. Grade: >95% by HPLC. CAS No. 95398-45-1. Molecular formula: C38H50N6O8. Mole weight: 718.84. | |
| A-54556B | A-54556B is a natural acyldepsipeptide (ADEP) antibiotic isolated from the fermentation broth of S. hawaiiensis. It has activity against Gram-positive bacteria and many strains of anaerobic bacteria. Synonyms: A-54556 Factor B; Antibiotic A-54556B; N-[(2E,?4E,?6E)?-1-Oxo-2,?4,?6-octatrien-1-yl]?-L-phenylalanyl-L-seryl-L-prolyl-N-methyl-L-alanyl-L-alanyl-L-proline (6→2)?-lactone. Grade: ≥98%. CAS No. 1629166-56-8. Molecular formula: C37H48N6O8. Mole weight: 704.81. | |
| A549 Transfection Reagent | BOC Sciences offers reagents specifically formulated and optimized for the transfection of A549. Uses: Lung cancer research and drug discovery and gene expression studies. | |
| A 582941 | A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively). Synonyms: A-582941; A 582941; A582941; Octahydro-2-methyl-5-(6-phenyl-3-pyridazinyl)-pyrrolo[3,4-c]pyrrole; (3aR,6aS)-2-methyl-5-(6-phenylpyridazin-3-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole. Grade: ≥98% by HPLC. CAS No. 848591-90-2. Molecular formula: C17H20N4. Mole weight: 280.37. | |
| A 582941 HCl | A 582941 is a selective α7 nAChR partial agonist which is effetive for both rat and human α7 receptors (Ki = 10.8 and 16.7 nM respectively). Synonyms: A-582941 HCl; A582941 HCl. Molecular formula: C17H21ClN4. Mole weight: 316.83. | |
| A 58365 A | A58365 A is an enzyme inhibitor produced by Streptomyces chromofuscus A58365.1. It has the effect of inhibiting angiotensin transferase (ACE). Synonyms: 6-Indolizinepropanoic acid, 3-carboxy-1,2,3,5-tetrahydro-8-hydroxy-5-oxo-, (-)-. Grade: >98%. CAS No. 87896-52-4. Molecular formula: C12H13NO6. Mole weight: 267.23. | |
| A 58365 B | A58365 B is an enzyme inhibitor produced by Streptomyces chromofuscus A58365.1. It has the effect of inhibiting angiotensin transferase (ACE). Synonyms: 2H-Quinolizine-7-propanoic acid, 4-carboxy-1,3,4,6-tetrahydro-9-hydroxy-6-oxo-. Grade: >98%. CAS No. 87896-53-5. Molecular formula: C13H15NO6. Mole weight: 281.26. | |
| A 61603 hydrobromide | A 61603 hydrobromide is a potent and selective α-adrenoceptor agonist with 35-fold selectivity for α1A over α1B or α1D sites. Activation of the α1A-adrenergic receptor by A 61603 induces dose response increases in spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nmol/L). Synonyms: A61603 Hydrobromide; A 61603 Hydrobromide; A-61603 Hydrobromide; N-[5-(4,5-Dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide hydrobromide. CAS No. 107756-30-9. Molecular formula: C14H19N3O3S.HBr. Mole weight: 390.29. | |
| A632668 | A632668. Synonyms: 4-amino-1,1,1-trifluorobutan-2-ol hydrochloride; 4-amino-1,1,1-trifluorobutan-2-ol; hydrochloride; 4-Amino-2-hydroxy-1,1,1-trifluorobutane HCl; 4-amino-1,1,1-trifluorobutan-2-olhydrochloride. CAS No. 1311317-62-0. Molecular formula: C4H8NOF3·HCl. Mole weight: 143.11 + (36.46). | |
| A66 | Inhibition of p110α alone by A66 treatment is sufficient to block insulin signalling to Akt/PKB in certain cell lines that harbor H1047R mutations in PIK3CA and have high levels of p110α and class-Ia PI3K activity. Synonyms: A66; A-66; A 66. Grade: >98%. CAS No. 1166227-08-2. Molecular formula: C17H23N5O2S2. Mole weight: 393.53. | |
| A6770 | A6770, a potentially key metabolite of THI, induces [3H]dhS1P increase and is a potent and orally active inhibitor of sphingosine 1-phosphate lyase (S1PL). A6770 is phosphorylated, and the phosphorylated form directly inhibits S1P lyased. Synonyms: Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-; 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]ethan-1-one. Grade: ≥95%. CAS No. 1331754-16-5. Molecular formula: C6H8N2O2. Mole weight: 140.14. | |
| A68930 | A68930 is a dopamine D1 receptor agonist that can be used in the study of bronchiectasis. Uses: Dopamine agonists. Synonyms: 5,6-Dihydroxy-3-phenyl-1-aminomethylisochroman; 1H-2-Benzopyran-5,6-diol, 1-(aminomethyl)-3,4-dihydro-3-phenyl-, (1R-cis)-; (1R,3S)-1-Aminomethyl-3-phenyl-isochroman-5,6-diol; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-2-benzopyran-5,6-diol. Grade: 95%. CAS No. 130465-45-1. Molecular formula: C16H17NO3. Mole weight: 271.31. | |
| A 68930 hydrochloride | A 68930 hydrochloride is a potent and selective dopamine D1-like receptor agonist (EC50 = 2.1 and 3910 nM for D1-like and D2-like receptors, respectively). Synonyms: A-68930 hydrochloride; A 68930 hydrochloride; A68930 hydrochloride; cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride; (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol hydrochloride. Grade: ≥98% by HPLC. CAS No. 130465-39-3. Molecular formula: C16H17NO3.HCl. Mole weight: 307.78. | |
| A7132 | A7132 is an antibacterial agent and possesses broad and potent antibacterial activity. Synonyms: 6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. CAS No. 100490-21-9. Molecular formula: C19H16F2N4O3. Mole weight: 386.35. | |
| A 71378 | A 71378 is a high potency, selectivity CCK-A receptors agonist with the IC50 values of 0.4 nM, 300 nM, and 1,200 nM for the pancreatic CCK-A, cortical CCK-B, and gastrin receptor, respectively. Synonyms: A-71378; Desamino-tyr(SO3H)-nle-gly-trp-nle-(N-methyl)asp-phe-NH2. CAS No. 127902-33-4. Molecular formula: C48H62N8O13S. Mole weight: 991.12. | |
| A 71915 | A 71915 is a highly potent and competitive natriuretic peptide receptor A (NPRA) antagonist (pKi = 9.18). Synonyms: (Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat); H-Arg-Cys-β-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13); L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic(2→13)-disulfide. Grade: ≥95%. CAS No. 132956-87-7. Molecular formula: C69H116N26O15S2. Mole weight: 1613.95. | |
| A 77636 hydrochloride | A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 = 8.97 and < 5 for D1-like and D2-like receptors, respectively). A 77636 exhibits anti-Parkinsonian activity following oral administration in vivo. Uses: Potential treatment of neurological disorders. Synonyms: A-77636 hydrochloride; A77636 hydrochloride; A77636 hydrochloride; (1R-cis)-1-(Aminomethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diol hydrochloride. Grade: ≥98% by HPLC. CAS No. 145307-34-2. Molecular formula: C20H27NO3.HCl. Mole weight: 365.9. | |
| A 779 | A 779 is a specific antagonist of G-protein coupled receptor (Mas receptor) (IC50 = 0.3 nM) with no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. Synonyms: A-779; A779; (D-Ala7)-Angiotensin I/II (1-7); Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH; 5-L-isoleucine-7-D-alanine-1-7-angiotensin II; 7-Ala-angiotensin (1-7); A 778; A 779; A-778; A779 peptide; angiotensin (1-7), Ala(7)-; angiotensin (1-7), alanyl(7)-; Asp-Arg-Val-Tyr-Ile-His-Ala; aspartyl-arginyl-valyl-tyrosyl-isoleucyl-histidyl-alanine. Grade: 98%. CAS No. 159432-28-7. Molecular formula: C39H60N12O11. Mole weight: 872.97. | |
| A 779 TFA | A 779 TFA is a potent angiotensin (1-7) receptor antagonist. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH.TFA; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-D-alanine trifluoroacetic acid; A-779 trifluoroacetate salt; (D-Ala7)-Angiotensin I/II (1-7) Trifluoroacetate; 5-L-Isoleucine-7-D-alanine-1-7-angiotensin II trifluoroacetate; A 779 TFA. Grade: ≥95%. Molecular formula: C41H61F3N12O13. Mole weight: 987.01. | |
| A 784168 | A 784168 is a potent and selective TRPV1 antagonist (IC50 = 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin) exhibiting no activity against a range of receptors such as TRPA1, GABA, opioid, and purinergic receptors. Synonyms: A 784168; A784168; A-784168; 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide; 1-[3-(trifluoromethyl)pyridin-2-yl]-N-[4-(trifluoromethylsulfonyl)phenyl]-3,6-dihydro-2H-pyridine-4-carboxamide. Grade: ≥99% by HPLC. CAS No. 824982-41-4. Molecular formula: C19H15F6N3O3S. Mole weight: 479.4. | |
| A 790742 | A 790742. CAS No. 854755-48-9. Molecular formula: C49H65N7O7. Mole weight: 864.1. | |
| A 792611 | A 792611. CAS No. 854758-17-1. Molecular formula: C47H60N6O6. Mole weight: 805. | |
| A 80426 | A 80426 is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity for a panel of structurally homologous GPCRs. Synonyms: A-80426; A80426; (R)-2-(Benzofuran-6-yl)-N-((5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)methyl)-N-methylethanamine. Grade: >98 %. CAS No. 152148-63-5. Molecular formula: C23H27NO2. Mole weight: 349.5. | |
| A 80426 mesylate | A 80426 mesylate is a potent α2-adrenoceptor antagonist and a selective 5-HT uptake inhibitor (Ki = 2.01 and 3.77 nM, respectively). It displays low affinity for a panel of structurally homologous GPCRs. Synonyms: A-80426 mesylate; A 80426 mesylate; A80426 mesylate; N-Methyl-N-[[(1R)-1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl]methyl]-6-benzofuranethanamine mesylate. Grade: ≥98% by HPLC. CAS No. 152148-64-6. Molecular formula: C23H27NO2.CH3SO3H. Mole weight: 445.57. | |
| A 804598 | A 804598 is a potent and competitive P2X7 receptor antagonist (IC50 = 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors, respectively). Synonyms: A-804598; A 804598; A804598. N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine; 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine. Grade: ≥99% by HPLC. CAS No. 1125758-85-1. Molecular formula: C19H17N5. Mole weight: 315.37. | |
| A81988 | A81988 is a potent, orally active angiotensin I1 antagonist with a long duration of action whose pharmacological profile has established it as an important tool for the investigation of a variety of A11 mediated pathological conditions. Uses: Angiotensin ii type 1 receptor blockers. Synonyms: 2-[propyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyridine-3-carboxylic acid; 2-(N-propyl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)amino)pyridine-3-carboxylic acid; A 81988; A-81988; A81988; Abbott 81988; Abbott-81988. CAS No. 141887-34-5. Molecular formula: C23H22N6O2. Mole weight: 414.46. | |
| A83016A | A83016A is a kinamycin antibiotic produced by an unidentified actinomycete 83016. It has activity against gram-positive bacteria such as Staphylococcus, Streptococcus, Streptococcus pneumoniae and Enterococcus. The MIC is between 0.06-4.0 μg/mL, similar to other members of the Kinamycin group. Synonyms: 1-(Acetyloxy)-5-cyano-3,7-dihydroxy-3-methyl-6,11-dioxo-2,3,4,5,6,11-hexahydro-1H-benzo[b]carbazole-2,4-diyl bis(2-methylpropanoate). Grade: >98%. CAS No. 142383-42-4. Molecular formula: C28H28N2O10. Mole weight: 552.53. | |
| A83016F | A83016F is an Aurodox antibiotic produced by an unidentified actinomycete 83016F. It has weak antibacterial activity. Synonyms: A-83016F; A 83016F. Grade: >98%. CAS No. 142435-72-1. Molecular formula: C37H55NO10. Mole weight: 673.83. | |
| A 83-01 sodium | A-83-01 is a small molecule inhibitor, which was found to be more potent in the inhibition of ALK5. Synonyms: A 83-01 (sodium salt). Grade: 95%. Molecular formula: C25H19N5NaS+. Mole weight: 444.51. | |
| A83586C | A83586C is an ester peptide antibiotic produced by Streptomyces karnatakensis. It has strong anti-Gram-positive bacteria activity, and the MIC of Staphylococcus aureus and Streptococcus is 0.008-0.06 μg/mL. The IC50 for human T-cell leukemia CCRF-CEM cells is 0.0135 μg/mL. Synonyms: Antibiotic A 83586C. Grade: >98%. CAS No. 116364-81-9. Molecular formula: C47H76N8O14. Mole weight: 977.15. | |
| A 839977 | A-839977 is a novel and selective P2X7 antagonist. It blocks BzATP-evoked calcium influx at recombinant human, rat and mouse P2X7 receptors with IC50 values 20, 42 and 150 nM respectively. It also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells. It also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice. It has been exhibited to reduce CFA-induced thermal hyperalgesia in a dose-dependent fashion with the ED50 value of 100μmol/kg. Synonyms: 1-(2,3-Dichlorophenyl)-N-[[2-[(pyridin-2-yl)oxy]phenyl]methyl]-1H-tetrazol-5-amine. Grade: >98 %. CAS No. 870061-27-1. Molecular formula: C19H14Cl2N6O. Mole weight: 413.26. | |
| A 841720 | A 841720 is a potent non-competitive mGlu1 receptor antagonist (IC50 = 10 nM) exhibiting 34-fold selectivity over mGluR5 and inactive to other mGluR receptors, neurotransmitter receptors, ion channels, and transporters. It inhibits complete Freund's adjuvant-induced inflammatory pain (ED50 = 23 μmol/kg) and decreases mechanical allodynia (ED50 = 28 μmol/kg) in mouse models. Synonyms: A-841720; A 841720; A841720; 3-(azepan-1-yl)-9-(dimethylamino)pyrido[1,2]thieno[3,4-d]pyrimidin-4-one. Grade: 99%. CAS No. 869802-58-4. Molecular formula: C17H21N5OS. Mole weight: 343.45. | |
| A 844606 | A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) partial agonist (EC50 = 1.4 and 2.2 μM at human and rat receptors, respectively). It has no measurable effect on α4β2 nAChRs. Synonyms: A 844606; A844606; A-844606; 2-(Hexahydro-5-methylpyrrolo[3,4-c]pyrrol-2(1H)-yl)-9H-xanthen-9-one. Grade: ≥99% by HPLC. CAS No. 861119-08-6. Molecular formula: C20H20N2O2. Mole weight: 320.38. | |
| A 848837 | A 848837. CAS No. 847442-91-5. Molecular formula: C25H29N3O6S2. Mole weight: 531.6. | |
| A 85380 dihydrochloride | A 85380 dihydrochloride is a selective α4β2 nACh receptor agonist (Ki = 0.05, 148 and 314 nM for α4β2, α7 and α1β1δγ receptors, respectively). Synonyms: A 85380 dihydrochloride; A85380 dihydrochloride; A-85380 dihydrochloride; 3-[(2S)-2-Azetidinylmethoxy]-pyridine dihydrochloride. Grade: ≥98% by HPLC. CAS No. 174740-86-4. Molecular formula: C9H12N2O.2HCl. Mole weight: 237.13. | |
| A 876828 | A 876828. CAS No. 909106-60-1. Molecular formula: C30H32N4O6S2. Mole weight: 608.7. | |
| A 887826 | A 887826 is a potent voltage-dependent NaV1.8 channel blocker (IC50 = 11 nM in recombinant human NaV1.8 channels). A 887826 is effective on reducing tactile allodynia in neuropathic rat models. Synonyms: A 887826; A887826; A-887826; 5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide. Grade: ≥97% by HPLC. CAS No. 1266212-81-0. Molecular formula: C26H29ClN4O3. Mole weight: 480.99. | |
| AA 147 | AA 147 is an endoplasmic reticulum (ER) proteostasis regulator. Activates the ATF6 transcriptional program independently of ER stress and/or global UPR activation. Selectively reduces secretion of amyloidogenic transthyretin (TTR) from HepG2 cells. Reduces amyloidogenic immunoglobulin light chain (ALLC) secretion from ALMC-2 cells (EC50 = 1.1 μM). Synonyms: N-(2-Hydroxy-5-methylphenyl)benzenepropanamide; N-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide. Grade: ≥98%. CAS No. 393121-74-9. Molecular formula: C16H17NO2. Mole weight: 255.31. | |
| AA26-9 | AA26-9, synthesized based on a piperazine scaffold, is a potent and broad spectrum serine hydrolase inhibitor. Synonyms: AA 26-9; AA-26-9; AA26-9; AA 269; AA-269; AA269; pyrrolidin-1-yl(triazol-1-yl)methanone; Pyrrolidin-1-yl(1H-1,2,3-triazol-1-yl)methanone. CAS No. 1312782-34-5. Molecular formula: C7H10N4O. Mole weight: 166.18. | |
| AA 29504 | AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes. AA 29504 is potentially used for the treatment of schizophrenia. Uses: Potential treatment of schizophrenia. Synonyms: AA 29504; AA29504; AA-29504; N1-Ethoxycarbonyl-N4-[(2,4,6-trimethylpheny)lmethyl]-1,2,4-triaminobenzene; ethyl N-[2-amino-4-[(2,4,6-trimethylphenyl)methylamino]phenyl]carbamate. Grade: ≥98% by HPLC. CAS No. 945828-50-2. Molecular formula: C19H25N3O2. Mole weight: 327.42. | |
| AA38-3 | AA38-3 is a serine hydrolase (SH) inhibitor that can inhibit three SHs, ABHD6, ABHD11, and FAAH. Synonyms: 4-Nitrophenyl piperidine-1-carboxylate; 1-Piperidinecarboxylic acid, 4-nitrophenyl ester; 4-Nitrophenyl 1-piperidinecarboxylate. Grade: ≥95%. CAS No. 65815-76-1. Molecular formula: C12H14N2O4. Mole weight: 250.25. | |
| AA3-DLin | AA3-Dlin is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA. Synonyms: Piperazine-bis(ethyl octadeca-9,12-dienoate); HY-148830; CS-0642689; Piperazine-1,4-diylbis(ethane-2,1-diyl) (9E,9'E,12E,12'E)-bis(octadeca-9,12-dienoate); 2832061-33-1. CAS No. 2832061-33-1. Molecular formula: C44H78N2O4. Mole weight: 699.1. | |
| AA41612 | AA41612 is a novel antagonist of melanopsin-mediated phototransduction. Synonyms: AA 41612; AA-41612; 1-((2,5-Dichloro-4-methoxyphenyl)sulfonyl)piperidine. Grade: >98%. CAS No. 433690-62-1. Molecular formula: C12H15Cl2NO3S. Mole weight: 324.22. | |
| AA-57 | AA-57 is an acidic lipophilic antibiotic produced by Streptomyces sp. AA-57. It has anti-gram-positive bacteria, negative bacteria and mycobacterial activity. Synonyms: AA-57; Pentaleno(1,6a-c)pyran-5-carboxylic acid, 1-(chloromethyl)-1,2,4,4a,6a,7-hexahydro-1-hydroxy-7,8-dimethyl-2-oxo-, (1S-(1alpha,4aalpha,6abeta,7alpha,9aR*))-; Pentaleno(1,3a-c)pyran-5-carboxylic acid, 1,2,4,4a,6a,7-hexadyro-1-(chloromethyl)-7,8-dimethyl-1-hydroxy-2-oxo-. Grade: >98%. CAS No. 68026-87-9. Molecular formula: C15H17ClO5. Mole weight: 312.74. | |
| AA-861 | AA-861. Synonyms: 2-[12-HYDROXYDODECA-5,10-DIYNYL]-3,5,6-TRIMETHYL-P-BENZOQUINONE; AA-861; docebenone; 2-(12-Hydroxy-5,10-dodecadiynyl)-3,5,6-trimethyl-2,5-cyclohexadiene-1,4-dione; 2-(12-Hydroxydodecane-5,10-diynyl)-3,5,6-trimethyl-p-benzoquinone; Decebenone. CAS No. 80809-81-0. Molecular formula: C21H26O3. Mole weight: 326.43. | |
| AA92593 | AA92593 is a selective and competitive OPN4 (melanopsin) antagonist. It blocks melanopsin activity and stimulates α-melanocyte-stimulating hormone (α-MSH) expression and induces melanin distribution in the melanophores, which darkens the embryo. Synonyms: 1-((4-Methoxy-3-methylphenyl)sulfonyl)piperidine. Grade: >98%. CAS No. 457961-34-1. Molecular formula: C13H19NO3S. Mole weight: 269.36. | |
| AAA-10 formic | AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor. Molecular formula: C26H43FO7S. Mole weight: 518.68. | |
| AA-AMPSA | AA/AMPS is the copolymer of acrylic acid and 2-acrylanmido-2-methylpropanesulfonic acid (AMPS). Uses: Aa/amps can be used as scale inhibitor and dispersant in open circulating cooling water system, oilfield refill water system, metallurgy system and iron & steel plants to prevent sediment of ferric oxide. when built with organophosphorines and zinc salt, the suitable ph value is 7.0~9. 5. aa/amps can also be used as dyeing auxiliaries for textile. Synonyms: AA-AMPS; Acrylic Acid-2-Acrylamido-2-Methylpropane Sulfonic Acid Copolymer; Sulfonated Polyacrylic Acid Copolymer. CAS No. 40623-75-4. | |
| AABD-SH (4-Acetamido-7-mercapto-2,1,3-benzoxadiazole | AABD-SH (4-Acetamido-7-mercapto-2,1,3-benzoxadiazole) [for HPLC Labeling] is usefuil for developing an ultrafine atmospheric pressure plasma jet. Synonyms: AABD-SH; N-(4-sulfanyl-2,1,3-benzoxadiazol-7-yl)acetamide; N-(7-SULFANYL-2,1,3-BENZOXADIAZOL-4-YL)ACETAMIDE; 4-Acetamido-7-mercaptobenzofurazan. CAS No. 254973-02-9. Molecular formula: C8H7N3O2S. Mole weight: 209.22. | |
| Aacephate-[Methoxy-d3,Thiomethoxy-d3] | Acephate-[d6] is a labelled Acephate, which is an organophosphate foliar insecticide. Synonyms: Aacephate (methoxy-d3,thiomethoxy-d3). Grade: 98% by CP; 98% atom D. CAS No. 2109699-73-0. Molecular formula: C4H4D6NO3PS. Mole weight: 189.20. | |
| AACOCF | AACOCF, an anlogue of arachidonic acid, is a slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2. It also inhibits fatty acid amide hydrolase (FAAH, anandamide amidase) in vitro. Synonyms: 1,1,1-Trifluoro-6Z,9Z,12Z,15Z-heneicosateraen-2-one; Arachidonyl trifluoromethyl ketone; Arachidonyltrifluoromethane. CAS No. 149301-79-1. Molecular formula: C21H31F3O. Mole weight: 356.47. | |
| AADvac-1 | AADvac-1 is an active vaccine designed to raise antibodies against pathological tau protein (the primary constituent of neurofibrillary pathology in AD). These antibodies are expected to prevent tau protein from aggregating, to facilitate the removal of tau protein aggregates and prevent the spreading of pathology, slowing or halting the progress of the disease. Synonyms: AADvac-1; Alzheimer's disease vaccine - Axon Neuroscience; Axon peptide 108 conjugated to KLH; Axon peptide 108 coupled to KLH. CAS No. 2307465-24-1. | |
| AAE871 | AAE871 is a type I FLT3 inhibitor. Synonyms: AAE-871; AAE 871; 9H-Purine-2,6-diamine, N2-(trans-4-aminocyclohexyl)-9-ethyl-N6-[4-(1-piperidinylsulfonyl)phenyl]-. Grade: >98%. CAS No. 289479-07-8. Molecular formula: C24H34N8O2S. Mole weight: 498.64. | |
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