BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
| Product | Description | |
|---|---|---|
| ABT-089 | ABT-089. CAS No. 161417-13-6. Molecular formula: C10H14N2O. Mole weight: 178.23. |  |
| ABT 089 dihydrochloride | ABT 089 dihydrochloride is a selective α4β2 nicotinic acetylcholine receptor partial agonist (Ki = 16 nM) with >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors, respectively. ABT 089 dihydrochloride is used as a nootropic and neuroprotective agent. Uses: Nootropic and neuroprotective agent. Synonyms: ABT 089 dihydrochloride; ABT089 dihydrochloride; ABT-089 dihydrochloride; 2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride; Pozanicline hydrochloride. Grade: ≥98% by HPLC. CAS No. 161416-61-1. Molecular formula: C11H16N2O.2HCl. Mole weight: 265.18. | |
| ABT-100 | ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity. Synonyms: ABT 100; ABT100; A-367074; A 367074; A367074. Grade: >98%. CAS No. 450839-40-4. Molecular formula: C27H19F3N4O3. Mole weight: 504.47. | |
| ABT-102 | ABT 102 is a selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with IC50 values to be 5-7 nM. No recent reports of development identified for phase-I development in Pain in USA. Uses: Pain. Synonyms: ABT 102; ABT-102; ABT102; CHEMBL398338; 1-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-3-(1H-indazol-4-yl)urea. Grade: 98%. CAS No. 808756-71-0. Molecular formula: C21H24N4O. Mole weight: 348.44. | |
| ABT-102 HCl | ABT-102 is a selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. Synonyms: ABT-102 HCl salt; ABT-102 hydrochloride. CAS No. 808757-00-8. Molecular formula: C22H26ClN3O. Mole weight: 383.9. | |
| ABT-107 | ABT-107 is a potent and selective α7 nAChR agonist with Ki of 0.2-0.6 nM for rat or human cortex α7 nAChRs. Synonyms: ABT-PR1; (R)-3-((6-(1H-Indol-5-yl)pyridazin-3-yl)oxy)quinuclidine. Grade: 98%. CAS No. 855291-54-2. Molecular formula: C19H20N4O. Mole weight: 320.39. | |
| ABT116 | ABT116 is an antagonist of transient receptor potential vanilloid type 1. Synonyms: ABT-116; ABT 116; ABT116; 1-[[2-(3,3-dimethylbutyl)-4-(trifluoromethyl)phenyl]methyl]-3-(1-methylindazol-4-yl)urea. Grade: >98 %. CAS No. 1008529-42-7. Molecular formula: C23H27F3N4O. Mole weight: 432.49. | |
| ABT199 intermediate 1 | ABT199 intermediate 1 (CAS# 1628047-87-9 ) is a useful research chemical. Synonyms: Piperazine, 1-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-, hydrochloride (1:2); 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazine dihydrochloride; 1-((2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-enyl)methyl)piperazine dihydrochloride; 1-{[2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazine dihydrochloride; 1-([2-(4-Chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl)piperazine 2HCl salt. CAS No. 1628047-87-9. Molecular formula: C19H29Cl3N2. Mole weight: 391.80. | |
| ABT199 intermediate 3 | ABT199 intermediate 3 (CAS# 1228780-72-0 ) is a useful research chemical. Synonyms: 1-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methy)piperazine; Venetoclax Intermediate 1; UNII-827EXU9VXN; 827EXU9VXN. CAS No. 1228780-72-0. Molecular formula: C19H27ClN2. Mole weight: 318.88. | |
| ABT-20 | ABT-202, a small molecule, asts as an agonist at neural nicotinic acetylcholine receptors. Uses: An agonist at neural nicotinic acetylcholine receptors and has been researched for use as an analgesic. Synonyms: ABT-202; ABT 202; ABT202; (3R)-1-(Pyridin-3-yl)pyrrolidin-3-amine. Grade: ≥98%. CAS No. 309959-34-0. Molecular formula: C9H13N3. Mole weight: 163.22. | |
| ABT-239 | ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist has been investigated as a treatment for ADHD, Alzheimer's disease, and schizophrenia. Uses: H3-receptor inverse agonist. Synonyms: ABT-239; ABT 239; ABT239; 4-(2-{2-[(2R)-2-Methylpyrrolidin-1-yl]ethyl}- benzofuran-5-yl)benzonitrile. Grade: ≥98%. CAS No. 460746-46-7. Molecular formula: C22H22N2O. Mole weight: 330.42. | |
| ABT 239 tartrate | ABT 239 tartrate is a potent and selective histamine H3 receptor antagonist or inverse agonist. Synonyms: ABT 239 tartrate; ABT239 tartrate; ABT-239 tartrate; (2R,3R)-2,3-dihydroxybutanedioic acid; 4-[2-[2-[(2R)-2-methylpyrrolidin-1-yl]ethyl]-1-benzofuran-5-yl]benzonitrile. Grade: 98%. CAS No. 460748-71-4. Molecular formula: C22H22N2O.C4H6O6. Mole weight: 480.51. | |
| ABT-255 | ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative bacterial infections. ABT-255 demonstrated in vitro potency and in vivo efficacy against both drug-susceptible and drug-resistant M. tuberculosis strains. Synonyms: 8-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid; ABT255; ABT 255; ABT-255; 186293-38-9; UNII-IMA7HK8V8X; 181141-52-6 (hydrochloride salt). Grade: >98%. CAS No. 186293-38-9. Molecular formula: C21H24FN3O3. Mole weight: 385.439. | |
| ABT-255 Hcl | ABT-255, a novel 2-pyridone antibacterial agent, is an analog of ABT-719 with improvements in the therapeutic margin against common gram-positive and -negative bacterial infections. ABT-255 demonstrated in vitro potency and in vivo efficacy against both drug-susceptible and drug-resistant M. tuberculosis strains. Synonyms: ABT-255 Hcl; ABT 255 Hcl; ABT255 Hcl; 8-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-7-fluoro-9-methyl-4-oxoquinolizine-3-carboxylic acid; hydrochloride; UNII-YA04O24J4T; 186293-38-9 (ABT-255 free base)SCHEMBL8471955; YA04O24J4T; 181141-52-6; 4H-Quinolizine-3-carboxylic acid, 1-cyclopropyl-7-fluoro-9-methyl-8-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-, monohydrochloride; 4H-Quinolizine-3-carboxylic acid, 1-cyclopropyl-7-fluoro-9-methyl-8-(octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-, monohydrochloride, (4as-cis)-. Grade: >98%. CAS No. 181141-52-6. Molecular formula: C21H25ClFN3O3. Mole weight: 421.89. | |
| ABT 263-[d8] | ABT 263-[d8] is a labelled ABT 263. ABT 263, also named Navitoclax, is an orally active, synthetic small molecule and an antagonist of a subset of the B-cell leukemia 2 (Bcl-2) family of proteins with potential antineoplastic activity. Synonyms: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide-d8. CAS No. 1217620-38-6. Molecular formula: C47H47D8ClF3N5O6S3. Mole weight: 982.66. | |
| ABT279 | ABT279 is a bio-active chemical coumpound. It is used for the treatment of type 2 diabetes. It was developed by Abbvie and was in clinical phase 1 trial, but now it is terminated. Uses: Abt279 is used for the treatment of type 2 diabetes. Synonyms: ABT-279; ABT 279; 4-Pyridinecarboxylic acid, 2-(4-((2-((2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl)-2-oxoethyl)amino)-4-methyl-1-piperidinyl)-. Grade: 98%. CAS No. 676559-83-4. Molecular formula: C21H25N5O3. Mole weight: 395.46. | |
| ABT 29666 | ABT 29666 is a therapeutic agent. Uses: A therapeutic agent. Synonyms: ABT 29666; ABT29666; ABT-29666; Piperidine, 1-(3-((4-((p-chlorophenyl)azo)-5,6,7,8-tetrahydro-1-naphthyl)amino)propyl)-. Grade: ≥98%. CAS No. 3365-99-9. Molecular formula: C24H31ClN4. Mole weight: 410.22. | |
| ABT-325 | ABT-325. | |
| ABT 38396 | ABT 38396 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: ABT 38396; ABT38396; ABT-38396; N-(5,6,7,8-tetrahydro-4-((6-methoxy-3-pyridinyl)azo)-1-naphthalenyl)-1-Piperidinepropanamine. Grade: ≥95%. CAS No. 4853-98-9. Molecular formula: C24H33N5O. Mole weight: 407.55. | |
| ABT 418 | ABT 418. CAS No. 147402-53-7. Molecular formula: C9H14N2O. Mole weight: 166.22. | |
| ABT-418 hydrochloride | ABT-418 is a neuronal nicotinic acetylcholine receptor agonist with anxiolytic and cognition enhancing activities. Synonyms: ABT-418 HCl; (S)-3-Methyl-5-(1-methylpyrrolidin-2-yl)-isoxazole HCl. Grade: 99%. CAS No. 147388-83-8. Molecular formula: C9H15ClN2O. Mole weight: 202.68. | |
| ABT-491 | ABT-491, an imidazopyridine derivative, has been found to be a PAF receptor antagonist that was once studied against allergic rhinitis. Synonyms: ABT-491 free base; ABT-491; ABT491; ABT 491; UNII-AYB44L739V; CHEMBL369225; ABT 491; 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide. Grade: 98%. CAS No. 170499-15-7. Molecular formula: C28H22FN5O2. Mole weight: 479.52. | |
| ABT-491 Hydrochloride | ABT-491 Hydrochloride is a potent, selective and orally active platelet-activating factor receptor (PAF-R) antagonist (Ki = 0.6 nM in human platelets). Synonyms: 4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-N,N-dimethylindole-1-carboxamide; hydrochloride; ABT 491 hydrochloride; ABT 491; ABT-491; ABT491. Grade: >98%. CAS No. 189689-94-9. Molecular formula: C28H23ClFN5O2. Mole weight: 515.97. | |
| ABT-510 | ABT-510 is a synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). Synonyms: ABT-510; ABT 510; ABT510. Grade: 98%. CAS No. 251579-55-2. Molecular formula: C46H83N13O11. Mole weight: 994.25. | |
| ABT-515 | ABT-515 is a formidable and discriminative antagonist exhibiting its capability by selectively inhibiting particular enzymes crucial in the advancement of malignant neoplasms. Synonyms: 1-[(2R)-4-[5-[(4-fluorophenyl)-hydroxymethyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea; ABT-515; 189328-52-7; ABT-515; UNII-186W5U73P9; ABT 515; ABT515. Grade: >98%. CAS No. 189328-52-7. Molecular formula: C16H15FN2O3S. Mole weight: 334.37. | |
| ABT-518 | ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis. Synonyms: ABT 518; ABT518; N-((S)-1-((S)-2,2-Dimethyl-1,3-dioxolan-4-yl)-2-((4-(4-(trifluoromethoxy)phenoxy)phenyl)sulfonyl)ethyl)-N-hydroxyformamide. CAS No. 286845-00-9. Molecular formula: C21H22F3NO8S. Mole weight: 505.46. | |
| ABT-546 | ABT-546 is a potent, highly selective and active antagonist of ETA receptor with a Ki of 0.46 nM for [125I]endothelin-1 binding to cloned human ETA. It is >25,000-fold more selectivity for ETA receptor than ETB receptor. It blocks endothelin-1-induced arachidonic acid release and phosphatidylinositol hydrolysis with IC50s of 0.59 and 3 nM, respectively. Synonyms: A-216546 free base; 3-Pyrrolidinecarboxylic acid, 1-(2-(dibutylamino)-2-oxoethyl)-2-(2,2-dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-, (2S,3R,4S)-; (2S,3R,4S)-1-[2-(Dibutylamino)-2-oxoethyl]-2-(2,2-dimethylpentyl)-4-(7-methoxy-1,3-benzodioxol-5-yl)-3-pyrrolidinecarboxylic acid. CAS No. 212481-66-8. Molecular formula: C30H48N2O6. Mole weight: 532.71. | |
| ABT-594 | ABT-594, also called as Tebanicline, the (R)-enantiomer of A-98593, is a potent synthetic non-opioid nicotinic analgesic drug. ABT-594 is a novel nAChR ligan which is shown to exert potent analgesic action in models of nociceptive and persistent pain and to possess substantially reduced activity at peripheral nAChRs. Synonyms: 5-[[(2R)-azetidin-2-yl]methoxy]-2-chloropyridine; Tebanicline; ABT-594; ABT 594; ABT594; Ebanicline. CAS No. 198283-73-7. Molecular formula: C9H11ClN2O. Mole weight: 198.65. | |
| ABT-639 | ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found to have potential effect against neuropathic and nociceptive pain in studies. It has already been discontinued in the treatment of diabetic neuropathies. Uses: Abt-639 is a new blocker of selective t-type ca2+ channel blocker that has been found to have potential effect against neuropathic and nociceptive pain in studies. Synonyms: ABT-639; ABT 639; ABT-639 free base; UNII-0G7D0CQ88I; SCHEMBL400073; 0G7D0CQ88I. Grade: 98%. CAS No. 1235560-28-7. Molecular formula: C20H20ClF2N3O3S. Mole weight: 455.91. | |
| ABT-639 hydrochloride | ABT-639 hydrochloride is a peripherally acting and selective T-type calcium channel blocker. Synonyms: 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide hydrochloride (1:1); Benzenesulfonamide, 4-chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]-, hydrochloride (1:1). Grade: ≥95%. CAS No. 1235560-31-2. Molecular formula: C20H21Cl2F2N3O3S. Mole weight: 492.37. | |
| ABT670 | ABT670 is a drug which acts as a potent, superior orally bioavailable dopamine agonist selective for the D4 subtype. It was used as a possible treatment for erectile dysfunction. Uses: Abt670 was used as a possible treatment for erectile dysfunction. Synonyms: ABT-670; ABT 670; Benzamide, 3-methyl-N-[[4-(1-oxido-2-pyridinyl)-1-piperidinyl]methyl]-; 3-Methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-(2,4'-bipyridine)-1'-ylmethyl)benzamide. Grade: 98%. CAS No. 630119-43-6. Molecular formula: C19H23N3O2. Mole weight: 325.41. | |
| ABT 702 | ABT 702 is a non-nucleoside adenosine kinase (ADK) inhibitor (IC50 = 2 nM and 50 nM in cytosolic and intact cell assays, respectively). Study conformed that ABT702 could reduce pain and inflammation in animal models, yet be clastogenic in an in vitro Chinese Hamster micronucleus assay. Synonyms: ABT 702; ABT702; ABT-702; 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-amine. Grade: 99%. CAS No. 214697-26-4. Molecular formula: C22H19BrN6O. Mole weight: 463.33. | |
| ABT 702 Dihydrochloride | ABT 702 Dihydrochloride is a potent and selective non-nucleoside adenosine kinase inhibitor with IC50 value of 1.7 nM. ABT 702 displays oral activity in animal models of pain and inflammation. In Mar 2005, ABT 702 was discontinued preclinical for Pain and Rheumatoid arthritis in USA. Uses: Anti-inflammation. Synonyms: ABT702 Dihydrochloride; ABT-702 Dihydrochloride. Grade: 98%. CAS No. 1188890-28-9. Molecular formula: C22H21BrCl2N6O. Mole weight: 536.26. | |
| ABT-719 | ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719; ABT719; ABT 719; ABT-719; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid. Grade: 98%. CAS No. 162829-90-5. Molecular formula: C18H20FN3O3. Mole weight: 345.23. | |
| ABT-719 HCl | The hydrochloride salt form of ABT-719, a fluoroquinolone derivative, has been found to be a DNA topoisomerase inhibitor that was once developed in antibacterial studies. Synonyms: ABT-719 HCl; ABT719 HCl; ABT 719 HCl; ABT-719 hydrochloride; A-816719.1; A 816719.1; A816719.1; (R)-8-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-7-fluoro-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid hydrochloride. Grade: 98%. CAS No. 162763-53-3. Molecular formula: C18H21ClFN3O3. Mole weight: 381.83. | |
| ABT724 | ABT-724 is a dopamine D4 agonist originated by Abbott Laboratories with EC50 value of 12.4 nM. In Dec 2007, Phase-II for Erectile dysfunction was discontinued in USA. Now ABT-724 continues to be used in scientific research into the function of the D4 receptor. Uses: Erectile dysfunction. Synonyms: ABT724; ABT 724; ABT-724; 2-((4-Pyridin-2-ylpiperazine-1-yl)methyl)-1H-benzimidazole; 587870-77-7(ABT 724 trihydrochloride). Grade: 98%. CAS No. 70006-24-5. Molecular formula: C17H19N5. Mole weight: 293.37. | |
| ABT 724 trihydrochloride | ABT 724 trihydrochloride is a potent dopamine D4 receptor partial agonist (EC50 = 12.4 nM; 61% efficacy vs. dopamine) for treatment of sexual dysfunction. Synonyms: 2-[[4-(2-Pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole trihydrochloride; ABT-724 trihydrochloride; ABT724 trihydrochloride; ABT 724 trihydrochloride. Grade: ≥99% by HPLC. CAS No. 587870-77-7. Molecular formula: C17H19N5.3HCl. Mole weight: 402.75. | |
| ABT-737 | ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: ABT 737; ABT737; (R)-4-(4-((4'-chloro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-nitrophenyl)sulfonyl)benzamide. Grade: 98%. CAS No. 852808-04-9. Molecular formula: C42H45ClN6O5S2. Mole weight: 813.43. | |
| ABT 737-[d8] | Labelled ABT-737. ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interaction of these proteins with pro-death proteins, leading to apoptosis. Synonyms: 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide-d8. CAS No. 1217686-68-4. Molecular formula: C42H37D8ClN6O5S2. Mole weight: 821.48. | |
| ABT 751 | ABT 751, also called E7010, is a novel bioavailable tubulin-binding and antimitotic agent that inhibits microtubule polymerization (in neuroblastoma: IC50 = 0.6-2.6 μM; in non-neuroblastoma cell lines: IC50 = 0.7-4.6 μM). Synonyms: N-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide; E 7010; E-7010; E7010; N-(2-((4-hydroxyphenyl)amino)-3-pyridinyl)-4-methoxybenzenesulfonamide; ABT-751; 141430-65-1; ABT 751; E-7010; ABT751; UNII-WDT5V5OB9F; E 7010; WDT5V5OB9F; CHEMBL20684. CAS No. 141430-65-1. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| ABT-770 | ABT-770 is a selective and orally bioavailable MMP inhibitor. Synonyms: ABT-770; ABT 770; ABT770; UNII-I8NWP25THF; N-[(2S)-1-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-3-[4-[4-(trifluoromethoxy)phenyl]phenoxy]propan-2-yl]-N-hydroxyformamide; UNII-I8NWP25THF; CHEMBL40143. Grade: >98%. CAS No. 220614-50-6. Molecular formula: C22H22F3N3O6. Mole weight: 481.42. | |
| ABT-866 | ABT-866 is a novel alpha-adrenoceptor agent that demonstrates intrinsic activity at the α1A-adrenoceptor subtype present in the rabbit urethra (pD2=6.22, with 80% of the phenylephrine response). Synonyms: N-[3-(1H-imidazol-5-ylmethyl)phenyl]ethanesulfonamide; ABT-866; ABT 866; ABT866; A 286666; A286666; A-286666. Grade: >98%. CAS No. 258526-74-8. Molecular formula: C12H15N3O2S. Mole weight: 265.33. | |
| ABT-888 | Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. Synonyms: ABT-888; ABT 888; ABT888. CAS No. 912445-05-7. Molecular formula: C13H18Cl2N4O. Mole weight: 317.21. | |
| ABT 925 Fumerate | A 437203 is a selective dopamine (DA) D3 receptor antagonist suited to evaluate the physiological role(s) of D3 receptors. A 437203 shows an approximately 100-fold higher in vitro affinity for dopamine D3 versus D2 receptors. Synonyms: (E)-but-2-enedioic acid; 2-[3-[4-[2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl]piperazin-1-yl]propylsulfanyl]-1H-pyrimidin-6-one; UNII-DMH23OL273; 220519-07-3 (anhydrous); 220519-06-2 (anhydrous free base); ABT-925 anhydrous; ABT 925 Fumerate; ABT925 Fumerate; ABT-925 Fumerate. Grade: >98%. CAS No. 220519-07-3. Molecular formula: C24H31F3N6O5S. Mole weight: 572.604. | |
| ABTL-0812 | ABTL-0812 is an orally bioavailable, lipid analogue and inhibitor of raptor-mammalian target of rapamycin (mTOR), rictor-mTOR and dihydrofolate reductase with potential antineoplastic activity. It binds to and inhibits both mTORC1 and mTORC2, which may result in apoptosis and a decrease in proliferation in mTORC1/2-expressing tumor cells upon oral administration. It was developed by Ability Pharmaceuticals and is in phase I/II clinical trials for the treatment of solid tumors. It received orphan drug designation in the E.U. and in the U.S. for the treatment of neuroblastoma in 2015. Uses: Abtl-0812 has potential antineoplastic activity. it is used for the treatment of solid tumors. Synonyms: ABTL0812; ABTL 0812; ABTL-0812; (9Z,12Z)-2-hydroxyoctadeca-9,12-dienoate. Grade: 98%. CAS No. 57818-44-7. Molecular formula: C18H31O3. Mole weight: 294.93. | |
| ABTS Chromophore Diammonium Salt | ABTS Chromophore Diammonium Salt can inhibit catalase, a mammalian antioxidant enzyme which degrades hydrogen peroxide into water and oxygen species. Synonyms: 2,2'-(1,2-Hydrazinediylidene)bis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Ammonium Salt (1:2); 2,2'-Azinobis[3-ethyl-2,3-dihydro-6-benzothiazolesulfonic Acid Diammonium Salt; 3-Ethyl-2-oxo-6-Benzothiazolinesulfonic Acid Azine Diammonium Salt; 2,2'-Azino-bis-(3-ethyl-benzthiazoline-6-sulfonate) Diammonium Salt; 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) Diammonium Salt; ABTS Diammonium Salt; Diammonium 2,2'-Azinobis(3-ethyl-6-benzothiazolinesulfonate); Diammonium 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate). Grade: ≥98%. CAS No. 30931-67-0. Molecular formula: C18H24N6O6S4. Mole weight: 548.68. | |
| Abu-Gly-OH | Abu-Gly-OH. Synonyms: 2-Amino-N-butyric acid glycine. Grade: ≥ 98% (HPLC). CAS No. 16305-80-9. Molecular formula: C6H12N2O3. Mole weight: 160.17. | |
| ABX-1431 | ABX-1431 is an inhibitor of monoacylglycerol lipase (MAGL; IC50s = 14 and 27 nM for human and rat enzyme, respectively). Synonyms: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate. Grade: ≥98%. CAS No. 1446817-84-0. Molecular formula: C20H22F9N3O2. Mole weight: 507.3. | |
| ABX464-[13C6] | ABX464-[13C6]. Synonyms: [13C6]-ABX464. Molecular formula: C10[13C]6H10ClF3N2O. Mole weight: 344.67. | |
| ABX (ANTIBODY EXCHANGER) | ABX (ANTIBODY EXCHANGER). Synonyms: BAKERBOND(TM) ABX; BAKERBOND(TM) ABX PLUS; BAKERBOND(TM) WIDE-PORE ABX; ABX (ANTIBODY EXCHANGER); ABX PLUS (ANTIBODY EXCHANGER); XWP 500 POLYABX-35; XWP ABX. Grade: 95%. CAS No. 126850-08-6. Molecular formula: C4H11NO3. | |
| ABX-IL8 | ABX-IL8. | |
| Abyssinone V | Abyssinone V is extracted from the root bark of Erythrina mildbraedii. It is a protein tyrosine phosphatase-1B (PTP1B) inhibitor with IC50 values ranging from 14.8 to 39.7 microM. Synonyms: 77263-11-7; 5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one; NSC618154; 4H-1-Benzopyran-4-one,2,3-dihydro-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methyl-2-buten-1-yl)phenyl]-,(2S)-; NSC 618154; CHEMBL454332; NSC-618154; 5,7,4'-trihydroxy-3',5'-diprenylflavanone; 4H-1-Benzopyran-4-one,3-Dihydro-5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl]-, (S)-; 4H-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-3,5-bis(3-methyl-2-butenyl)phenyl)-, (S)-. CAS No. 77263-11-7. Molecular formula: C28H22O7. Mole weight: 470.5. | |
| Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide | Abz-Ala-Gly-Leu-Ala-p-nitrobenzylamide is a fluorogenic substrate for neutral metalloendopeptidases. Synonyms: XAGLA. CAS No. 100307-95-7. Molecular formula: C28H37N7O7. Mole weight: 583.63. | |
| Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH | Abz-Ala-Phe-Ala-Phe-Asp-Val-Phe-3-nitro-Tyr-Asp-OH is a fluorogenic (FRET) substrate for endoproteinase AspN, Asp-specific proteases from Staphylococcus aureus, Bacillus licheniformis and Streptomyces griseus. Synonyms: Fluorescent Substrate for Asp-Specific Proteases; (2-aminobenzoyl)-L-alanyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-alpha-aspartyl-L-valyl-L-phenylalanyl-3-nitro-L-tyrosyl-L-aspartic acid; Anthranilyl-Ala-Phe-Ala-Phe-Asp-Val-Phe-nitro-Tyr-Asp; N-(2-Aminobenzoyl)-L-alanyl-L-phenylalanyl-L-alanyl-L-phenylalanyl-L-α-aspartyl-L-valyl-L-phenylalanyl-3-nitro-L-tyrosyl-L-aspartic acid. Grade: 95%. CAS No. 143147-74-4. Molecular formula: C62H71N11O18. Mole weight: 1258.29. | |
| Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp | Abz-Ala-Pro-Glu-Glu-Ile-Met-Arg-Arg-Gln-EDDnp is a fluorescence-quenching substrate for Human Neutrophil Elastase. Synonyms: N-(2-aminobenzoyl)-L-alanyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-methionyl-L-arginyl-L-arginyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide. CAS No. 824405-61-0. Molecular formula: C61H93N21O19S. Mole weight: 1456.59. | |
| Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp | Abz-(Asn670,Leu671)-Amyloid β/A4 Protein Precursor770 (669-674)-EDDnp is an intramolecularly quenched fluorescent substrate with the ortho-aminobenzoyl (Abz)/N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor/acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence, which is targeted by β-secretase BACE (β-site APP-cleaving activity). It is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2). Synonyms: JMV2236; L-α-Glutamine, N-(2-aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-[2-[(2,4-dinitrophenyl)amino]ethyl]-; N-(2-Aminobenzoyl)-L-valyl-L-asparaginyl-L-leucyl-L-α-aspartyl-L-alanyl-N-{2-[(2,4-dinitrophenyl)amino]ethyl}-L-α-glutamine. Grade: ≥95%. CAS No. 1007306-20-8. Molecular formula: C42H58N12O16. Mole weight: 986.99. | |
| Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2 | Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2. Synonyms: Abz-Asp-Asp-Ile-Val-Pro-Cys-Ser-Met-Ser-3-nitro-Tyr-Thr-NH2. Grade: 95%. CAS No. 852572-93-1. Molecular formula: C58H84N14O22S2. Mole weight: 1393.51. | |
| ABZ-EIFVKKQ-EDDNP | ABZ-EIFVKKQ-EDDNP. Synonyms: ABZ-GLU-ILE-PHE-VAL-PHE-LYS-GLN-ETHYLENEDIAMINE-DNP; ABZ-EIFVKKQ-EDDNP. CAS No. 848491-08-7. Molecular formula: C60H80N14O15. Mole weight: 1237.38. | |
| Abz-EPFWEDQ-EDDnp | Abz-EPFWEDQ-EDDnp is a peptide used as a research tool for the study of protein interactions. Abz-EPFWEDQ-EDDnp acts as an activator of receptors and ion channels. Synonyms: Abz-Glu-Pro-Phe-Trp-Glu-Asp-Gln-EDDnp; N-(2-Aminobenzoyl)-L-α-glutamyl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-α-glutamyl-L-α-aspartyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide; L-Glutamamide, N-(2-aminobenzoyl)-L-α-glutamyl-L-prolyl-L-phenylalanyl-L-tryptophyl-L-α-glutamyl-L-α-aspartyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-. CAS No. 534615-70-8. Molecular formula: C59H68N14O19. Mole weight: 1277.26. | |
| Abz-FR-K(Dnp)-P-OH | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Synonyms: H-2Abz-Phe-Arg-Lys(Dnp)-Pro-OH; N-(2-Aminobenzoyl)-L-phenylalanyl-L-arginyl-N6-(2,4-dinitrophenyl)-L-lysyl-L-proline; o-Aminobenzoic acid-FRK(Dnp)P-OH; Abz-FR-K (Dnp)-P. Grade: ≥95%. CAS No. 500799-61-1. Molecular formula: C39H49N11O10. Mole weight: 831.87. | |
| Abz-FR-K(Dnp)-P-OH acetate | An angiotensin I-converting enzyme (ACE) substrate and an internally quenched fluorogenic substrate for real time fluorescent assay. Molecular formula: C41H53N11O12. Mole weight: 891.95. | |
| ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP | ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP. Synonyms: H-2-ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP; ABZ-GLN-VAL-VAL-ALA-GLY-ALA-ETHYLENEDIAMINE-DNP. Grade: 95%. CAS No. 152390-52-8. Molecular formula: C38H54N12O12. Mole weight: 870.91. | |
| ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2 | ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2. Synonyms: ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-P-NITRO-PHE-NH2; HUMAN RHINOVIRUS 3C PROTEASE SUBSTRATE; HRV 3C PROTEASE SUBSTRATE; H-2-ABZ-GLU-THR-LEU-PHE-GLN-GLY-PRO-VAL-4-NITRO-PHE-NH2. CAS No. 396096-53-0. Molecular formula: C57H77N13O16. Mole weight: 1200.3. | |
| ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH | ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH. Synonyms: ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH; H-2-ABZ-GLY-ALA-ALA-PRO-PHE-3-NITRO-TYR-ASP-OH; anthranilyl-Gly-Ala-Ala-Pro-Phe-nitro-Tyr-Asp. Grade: 95%. CAS No. 142689-23-4. Molecular formula: C42H49N9O14. Mole weight: 903.89. | |
| Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2 | Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2. Synonyms: Abz-Gly-Ala-Lys(Ac)-Ala-Ala-Dap(Dnp)-NH2. Grade: 95%. CAS No. 761443-02-1. Molecular formula: C37H49F3N12O14. | |
| Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH | Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH is a very efficient and selective FRET substrate for human cathepsin B (Km = 5.9 μM, kcat = 43 s-1, kcat/Km = 7288 mM-1s-1), with kcat/Km values of 133.3, 100, 32, 17, and 75 mM-1s-1 for cathepsin K, L, V, X, and cruzain, respectively. Synonyms: H-2Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH; Abz-GIVRAK(Dnp); L-Lysine, N-(2-aminobenzoyl)glycyl-L-isoleucyl-L-valyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-; N-(2-Aminobenzoyl)glycyl-L-isoleucylvalyl-L-arginyl-L-alanyl-N6-(2,4-dinitrophenyl)-L-lysine. Grade: ≥95%. CAS No. 827044-38-2. Molecular formula: C41H61N13O12. Mole weight: 928.02. | |
| Abz-LFK(Dnp)-OH trifluoroacetate salt | Abz-LFK(Dnp)-OH trifluoroacetate salt is an angiotensin-converting enzyme (ACE) fluorescent peptide substrate that binds specifically to the C domain of ACE. It has been used to investigate the development of novel antibacterial calixarene derivatives, as well as the efficacy and toxicity of antimicrobial peptide M33 as a possible antimicrobial agent for lung infections and sepsis. Synonyms: O-Aminobenzoic acid-Leu-Phe-Lys(DNP)-OH trifluoroacetate salt; Abz-Leu-Phe-Lys-DNP trifluoroacetate salt; (2-aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine trifluoroacetic acid; N-(2-Aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-L-lysine trifluoroacetate (1:1); L-Lysine, N-(2-aminobenzoyl)-L-leucyl-L-phenylalanyl-N6-(2,4-dinitrophenyl)-, compd. with 2,2,2-trifluoroacetic acid (1:1); (2S)-2-[[(2S)-2-([(2S)-2-[(2-Aminobenzoyl)amino]-4-methylpentanoyl]amino)-3-phenylpropanoyl]amino]-6-(2,4-dinitroanilino)hexanoic acid trifluoroacetate. Grade: ≥97% by HPLC. CAS No. 1217437-31-4. Molecular formula: C34H41N7O9.C2HF3O2. Mole weight: 805.76. | |
| ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2 | ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2. Synonyms: H-2-ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2; ABZ-LYS-PRO-LEU-GLY-LEU-DAP(DNP)-ALA-ARG-NH2. CAS No. 290362-09-3. Molecular formula: C50H77N17O13. Mole weight: 1124.25. | |
| Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate | Abz-Nle-Lys-Arg-Arg-Ser-3-(NO2)Tyr acetate. Molecular formula: C30H46O5. Mole weight: 486.68. | |
| Abz-Ser-Pro-3-nitro-Tyr-OH | Abz-Ser-Pro-3-nitro-Tyr-OH, a selective internal quenching fluorescence (FRET) substrate for angiotensin-converting enzyme 2 (ACE2), has potential application in the high-throughput screening of ACE2 inhibitors (Km = 23 μM, kcat/Km = 3.5ยท104 M-1s-1). Synonyms: H-2Abz-Ser-Pro-Tyr(3-NO2)-OH; (2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-L-tyrosine; L-Tyrosine, N-(2-aminobenzoyl)-L-seryl-L-prolyl-3-nitro-. Grade: ≥95%. CAS No. 553644-01-2. Molecular formula: C24H27N5O9. Mole weight: 529.51. | |
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