MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Piromelatine | Piromelatine (Neu-P11) is a melatonin MT 1 /MT 2 receptor agonist, serotonin 5-HT 1A / 5-HT 1D agonist, and serotonin 5-HT 2B antagonist. Piromelatine (Neu-P11) possesses sleep promoting, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potentials. Piromelatine (Neu-P11) also possesses pain-related P2X3, TRPV1, and Nav1.7 channel-inhibition capacities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Neu-P11. CAS No. 946846-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105285. |  |
| Piroxicam | Piroxicam (CP-16171) is a non-steroidal anti-inflammatory drugs, acts as a COX inhibitor, with IC 50 s of 47, 25 μM for human monocyte COX-1 and COX-2, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-16171. CAS No. 36322-90-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g; 10 g. Product ID: HY-B0253. | |
| Pirtobrutinib | Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LOXO-305. CAS No. 2101700-15-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131328. | |
| PIT | PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC 50 value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2,2'-Pyridylisatogen tosylate. CAS No. 56583-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108662. | |
| PIT-1 | PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 53501-41-0. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103224. | |
| Pitavastatin | Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104. CAS No. 147511-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B0144A. | |
| Pitavastatin Calcium | Pitavastatin Calcium (NK-104 hemicalcium) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin Calcium (NK-104 hemicalcium) inhibits cholesterol synthesis from acetic acid with an IC 50 of 5.8 nM in HepG2 cells. Pitavastatin Calcium is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Pitavastatin Calcium also possesses anti-atherosclerotic, anti-asthmatic, anti-osteoarthritis, antineoplastic, neuroprotective, hepatoprotective and reno-protective effects [1] [2] [3] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NK-104 hemicalcium; Pitavastatin hemicalcium. CAS No. 147526-32-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0144. | |
| Pitavastatin lactone | Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 141750-63-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-125643. | |
| Pitofenone hydrochloride | Pitofenone hydrochloride, a spasmolytic compound, inhibits the acetylcholinesterase ( AChE ) activity from bovine erythrocytes and from electric eel with K i s of 36 and 45 μM, respectively [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1248-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110389. | |
| Pitolisant | Pitolisant is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor ( K i =0.16 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tiprolisant. CAS No. 362665-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199. | |
| Pitolisant hydrochloride | Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor ( K i =0.16 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ciproxidine; BF 2649. CAS No. 903576-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12199B. | |
| Pivagabine | Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CXB-722. CAS No. 69542-93-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-108295. | |
| Pivekimab | Pivekimab is a human IgG1 monoclonal antibody that targets interleukin-3 (IL-3) and CD123. Pivekimab is used to synthesize pivekimab sunirine, a CD123-directed antibody-active molecule conjugate ( ADC ). Pivekimab is used in the study of blastic plasmacytoid dendritic cell neoplasm (BPDCN) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2234335-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99234. | |
| Pivmecillinam hydrochloride | Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FL-1039 hydrochloride. CAS No. 32887-03-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0810A. | |
| Pivmecillinam (hydrochloride) (Standard) | Pivmecillinam (hydrochloride) (Standard) is the analytical standard of Pivmecillinam (hydrochloride). This product is intended for research and analytical applications. Pivmecillinam hydrochloride (FL-1039 hydrochloride) is an orally active proagent of mecillinam, an extended-spectrum penicillin antibiotic. Uses: Scientific research. Group: Signaling pathways. CAS No. 32887-03-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0810AR. | |
| Pixantrone | Pixantrone (BBR 2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator, with anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BBR 2778. CAS No. 144675-97-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13727A. | |
| Pizotifen | Pizotifen (Pizotyline) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pizotyline; BC-105. CAS No. 15574-96-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-B0115. | |
| Pizotifen malate | Pizotifen malate (Pizotyline malate) is a potent 5-HT 2 receptor antagonist, with a high affinity for 5-HT 1C binding site. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pizotyline malate; BC-105 malate. CAS No. 5189-11-7. Pack Sizes: 100 mg. Product ID: HY-B0115A. | |
| PK 11195 | PK 11195 (RP 52028) is a ligand of translocator protein (TSPO) , which targets Leishmania chemotherapy, with IC 50 s of 14.2 μM, 8.2 μM, 3.5 μM for L. amazonensis , L. major and L. braziliensis , respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RP 52028. CAS No. 85532-75-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19567. | |
| PKC/PKD-IN-1 | PKC/PKD-IN-1 (Compound 13C) is an orally active dual protein kinase C/D ( PKC/PKD ) inhibitor with an IC 50 value of 0.6 nM for PKD1. PKC/PKD-IN-1 can attenuate high-salt diet-induced cardiac hypertrophy and can be used in the study of heart failure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1071135-06-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128142. | |
| PKCTheta-IN-2 | PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor with an IC 50 of 0.25 nM. PKCTheta-IN-2 shows good selectivity over a wide range of kinases, including the PKC subfamily (30 kinases). PKCTheta-IN-2 inhibits the IL-2 production in a mouse ( IC 50 of 682 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810742-60-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164756. | |
| PKCζ-IN-1 | PKCζ-IN-1 is a compound that inhibits PKCζ and CDK2, showing an IC50 value of 5.18 nM for PKCζ and 1.04 μM for CDK2, with significant selectivity of 200-fold. PKCζ-IN-1 can reduce the activity of CDK2 while inhibiting PKC&zeta. Uses: Scientific research. Group: Signaling pathways. CAS No. 1132609-87-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-120497. | |
| PKD-IN-1 dihydrochloride | PKD-IN-1 dihydrochloride (compound 32), an aminoethylamino-aryl (AEAA) compound, acts as PKD-1 inhibitor. PKD-IN-1 can be used for protein kinase D (PKD)-mediated diseases research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2308510-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131962A. | |
| PKG Substrate | PKG Substrate is a selective substrate for cGMP-dependent protein kinase ( PKG ). Uses: Scientific research. Group: Peptides. CAS No. 81187-14-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1561. | |
| PKR activator 3 | PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628428-01-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19702. | |
| PKSI-527 | PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128837-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123133. | |
| Pladienolide B | Pladienolide B is a potent cancer cell growth inhibitor that targets the SF3B1 subunit of the spliceosome. Pladienolide B exerts antitumor activities mediated through the inhibition of pre-mRNA splicing. Pladienolide B induces apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 445493-23-2. Pack Sizes: 100 μg; 500 μg. Product ID: HY-16399. | |
| Plamotamab | Plamotamab (XmAb-13676) is a human bispecific antibody (bsAb) that binds CD3 and CD20. Plamotamab recruits cytotoxic T cells to kill CD20 + expressing tumor cells. Plamotamab induces a mild hematologic reaction (MR), and results in tumor regression in vivo [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: XmAb-13676. CAS No. 2138442-31-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99776. | |
| Plantaricin A | Plantaricin A is an antimicrobial peptide derived from LactobacifZus plantarum against bacteria [1]. Uses: Scientific research. Group: Peptides. Alternative Names: PlnA. CAS No. 131463-18-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5589. | |
| Plasmin, Human plasma | Plasmin, Human plasma is an important protease present in blood that degrades many plasma proteins, including fibrin clots. Plasmin can also act as a potent regulator of the immune process and can directly interact with various cell types, including monocytes, macrophages, and dendritic cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Fibrinolysins, Human plasma; Serum tryptase, Human plasma; TAL 05-00018, Human plasma. CAS No. 9001-90-5. Pack Sizes: 100 μg; 500 μg. Product ID: HY-108883. | |
| Plasminogen, Human plasma | Plasminogen, Human plasma is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen also is a proinflammatory regulator that accelerates the healing of acute and diabetic wounds. Plasminogen can be used in studies of wound healing, inflammation and hypoplasminogenemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9001-91-6. Pack Sizes: 1 mg. Product ID: HY-P2821. | |
| Platycodin D | Platycodin D is a saponin isolated from Platycodon grandiflorus , acts as an activator of AMPKα , with anti-obesity property. WNT/β-catenin pathway mediates the anti-adipogenic effect of platycodin D [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 58479-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg. Product ID: HY-N1411. | |
| Platyconic acid A | Platyconic Acid A is an active component of changkil saponins from platycodon grandiflorum and can be used for the research of reducing airway inflammation [1]. Uses: Scientific research. Group: Natural products. CAS No. 68051-23-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N9377. | |
| Plecanatide | Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 467426-54-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108741. | |
| Plecanatide acetate | Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC 50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis [1] [2] [3]. Uses: Scientific research. Group: Peptides. CAS No. 1075732-84-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108741A. | |
| Pleconaril | Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. Pleconaril has potential for use in rhinoviruses and enteroviruses research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VP 63843; Win 63843. CAS No. 153168-05-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19952. | |
| Plerixafor | Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC 50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC 50 of 1-10 nM [1] [2] [3] [4] [7]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AMD 3100; JM3100; SID791. CAS No. 110078-46-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10046. | |
| Pleuromutilin | Pleuromutilin (Drosophilin B) exhibits antibacterial activity through inhibition of protein synthesis [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Drosophilin B; Mutilin 14-glycolate. CAS No. 125-65-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-N2301. | |
| PLGA (50:50) | PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: poly(lactic-co-glycolic acid) (50:50). CAS No. 34346-01-5. Pack Sizes: 500 mg; 1 g. Product ID: HY-B2247. | |
| Plicamycin | Plicamycin (Mithramycin A) is a selective specificity protein 1 ( Sp1 ) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mithramycin A. CAS No. 18378-89-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0122. | |
| Plinabulin | Plinabulin (NPI-2358) is a vascular disrupting agen ( VDA ) against tubulin-depolymerizing with an IC 50 of 9.8 nM against HT-29 cells [1]. Plinabulin binds the colchicine binding site of β-tubulin preventing polymerization and has potent inhibitory to tumor cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NPI-2358. CAS No. 714272-27-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14444. | |
| Plitidepsin | Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 ( K D =80?nM) [1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC 90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Aplidine; PM90001. CAS No. 137219-37-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16050. | |
| Plixorafenib | PLX8394 is a potent and selective BRaf inhibitor, with an IC 50 of appr 5 nM for BRAF V600E. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PLX8394; FORE8394. CAS No. 1393466-87-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18972. | |
| Plozalizumab | Plozalizumab (MLN-1202) is a specific humanized anti- CCR2 antibody. Plozalizumab can be used for malignant melanoma research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MLN-1202. CAS No. 1610761-46-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99781. | |
| PLP (139-151) | PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). Uses: Scientific research. Group: Peptides. CAS No. 131334-43-5. Pack Sizes: 5 mg. Product ID: HY-P0129. | |
| PLpro inhibitor | PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with an IC 50 of 2.6 μM [1]. PLpro inhibitor inhibits SARS-CoV-2 PLpro with an IC 50 of 5.0 μM and an EC 50 of 21.0 μM [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093070-14-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17542. | |
| Plumbagin | Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica , exhibits anticancer and antiproliferative activities [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methyljuglone. CAS No. 481-42-5. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N1497. | |
| Pluripotin | Pluripotin is a dual inhibitor of ERK1 and RasGAP with K D s of 98 nM and 212 nM, respectively. Pluripotin also inhibits RSK1 , RSK2 , RSK3 , and RSK4 with IC 50 s of 0.5, 2.5, 3.3, and 10.0 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC1. CAS No. 839707-37-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10579. | |
| PM-1 | PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1449483-78-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156404. | |
| PMSF | PMSF is an irreversible serine/cysteine protease inhibitor commonly used in the preparation of cell lysates. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride. CAS No. 329-98-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0496. | |
| Pneumocandin B0 | Pneumocandin B0 (L-688786), the precursor of the antifungal agent Caspofungin acetate, is an antifungal agent belonging to the echinocandin family. Pneumocandin B0, derived from the flamentous fungus Glarea lozoyensis , is a synthetic intermediate of Cancidas [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: L-688786. CAS No. 135575-42-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17578. | |
| PNGase F | PNGase F, a glycosidase, catalyzes the cleavage of an internal glycoside bond in an oligosaccharide. PNGase F removes nearly all N-linked oligosaccharides from glycoproteins. PNGase F can release N-glycans from glycoproteins in glycoanalytical workflows [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 83534-39-8. Pack Sizes: 10 KU. Product ID: HY-P2929. | |
| p-Nitrobenzyl mesylate | p-Nitrobenzyl mesylate (4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate) is a reagent used to alkylate phosphorothioates, forming phosphorothioate epitopes that can be recognized by specific antibodies. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Nitrobenzyl mesylate; para-Nitrobenzyl mesylate; PNBM. CAS No. 39628-94-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118380. | |
| p-nitro-Pifithrin-α | p-nitro-Pifithrin-α, a cell-permeable analog of pifithrin-α, is a potent p53 inhibitor. p-nitro-Pifithrin-α suppresses p53-mediated TGF-β1 expression in HK-2 cells. p-nitro-Pifithrin-α inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. p-nitro-Pifithrin-α attenuates steatosis and liver injury in mice fed a high-fat diet [4]. non-alcoholic fatty liver disease [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 389850-21-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130437. | |
| PNPP disodium | PNPP (Para-nitrophenyl phosphate) disodium is a non-proteinaceous chromogenic substrate for alkaline and acid phosphatases used in ELISA and conventional spectrophotometric assays. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Para-nitrophenyl phosphate disodium. CAS No. 4264-83-9. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15928. | |
| PNT6555 | PNT6555 is a fibroblast activation protein-α ( FAP ) inhibitor. PNT6555 has antitumor activity. PNT6555 can be used for imaging of FAP -positive tumors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2715113-34-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-161074. | |
| PNU-120596 | PNU-120596 (NSC 216666) is a potent and selective α7 nAChR positive allosteric modulator (PMA) with an EC 50 of 216 nM. PNU-120596 is inactive against α4β2, α3β4, and α9α10 nAChRs. PNU-120596 has the potential for psychiatric and neurological disorders research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 216666. CAS No. 501925-31-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12152. | |
| PNU-142633 | PNU-142633 is a high affinity, selective and orally active 5-HT 1D receptor agonist with K i s of 6 nM and > 18 000 nM for human 5-HT 1D receptor and human 5-HT 1B receptor, respectively. PNU-142633 has anti-migraine efficacy [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 187665-65-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-103131. | |
| PNU-22394 hydrochloride | PNU-22394 hydrochloride is an agonist for 5-HT , with K i of 6.1 and 10 nM, for 5-HT 2C and 5-HT 2A , respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 15923-42-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103145. | |
| PNU-282987 | PNU-282987 is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC 50 of 154 nM. PNU-282987 is also a functional antagonist of the 5-HT 3 receptor with an IC 50 of 4541 nM. PNU-282987 can be used for the research of central and peripheral nervous systems [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 123464-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12560A. | |
| PNU-74654 | PNU-74654 is an inhibitor of Wnt/β-catenin pathway with an IC 50 of 129.8 μM in NCI-H295 cell. Uses: Scientific research. Group: Signaling pathways. CAS No. 113906-27-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101130. | |
| Pociredir | Pociredir (FTX-6058) is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir can induce HbF protein expression in cell and murine models. Pociredir can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058. CAS No. 2490676-18-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-139400. | |
| Pociredir hydrochloride | Pociredir (FTX-6058) hydrochloride is a potent and orally active inhibitor of Embryonic Ectoderm Development (EED). Pociredir hydrochloride can induce HbF protein expression in cell and murine models. Pociredir hydrochloride can be used for the research of select hemoglobinopathies, including sickle cell disease and β-thalassemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTX-6058 hydrochloride. CAS No. 2490676-19-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139400A. | |
| Podofilox | Podofilox (Podophyllotoxin) is a potent inhibitor of microtubule assembly and DNA topoisomerase II. Uses: Scientific research. Group: Natural products. Alternative Names: Podophyllotoxin. CAS No. 518-28-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-15552. | |
| Podophyllotoxone | Podophyllotoxone is isolated from the roots of Dysosma versipellis and has anti-cancer activities.Podophyllotoxone is able to inhibit the tubulin polymerization [1]. Uses: Scientific research. Group: Natural products. CAS No. 477-49-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2415. | |
| Polaprezinc | Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zinc L-carnosine. CAS No. 107667-60-7. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0729. | |
| Polatuzumab | Polatuzumab is a monoclonal antibody, which targets CD79b that is found on the surface of B cells. Polatuzumab sticks to the CD79b protein and delivers the chemotherapy compound into the cell. Polatuzumab can be used to synthesize Polatuzumab Vedotin, which is an antibody-drug conjugate (ADC) targeting CD79b [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2279068-37-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99042. | |
| Polatuzumab vedotin | Polatuzumab vedotin is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin has the potential for the research of Large B-cell lymphomas (LBCL) [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1313206-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-132253. | |
| Polatuzumab vedotin (solution) | Polatuzumab vedotin solution is an antibody-drug conjugate targeting CD79b. It contains a humanized anti-CD79b IgG1 monoclonal antibody linked to monomethyl auristatin E (MMAE), a potent microtubule inhibitor. Polatuzumab vedotin solution has the potential for the research of Large B-cell lymphomas (LBCL) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313206-42-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132253A. | |
| Policresulen | Policresulen is a potent inhibitor of DENV2 NS2B/NS3 protease ( IC 50 of 0.48 μg/mL). Policresulen inhibits DENV2 replication in BHK-21 cells with IC 50 of 4.99 μg/mL. Policresulen acts as a competitive inhibitor of the protease, and slightly affects the protease stability [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 101418-00-2. Pack Sizes: 1 g; 5 g. Product ID: HY-W129596. | |
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