MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| ML230 | ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678. |  |
| ML240 | ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 value of 100 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346527-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19795. | |
| ML241 | ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC50 of 0.11 ?M. ML241 can be used for the research of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346528-06-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19797. | |
| ML254 | ML254 is a potent mGlu 5 potentiator, with EC 50 and pEC 50 of 9.3 nM and 8.03 nM for rat mGlu 5 , respectively. ML254 can be used for researching schizophrenia [1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428630-86-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16654. | |
| ML264 | ML264 is an antitumor agent that potently and selectively inhibits Krüppel-like factor five ( KLF5 ) expression. Uses: Scientific research. Group: Signaling pathways. CAS No. 1550008-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19994. | |
| ML277 | ML277 (CID-53347902) is a potent and selective activator of K(V)7.1 (KCNQ1) potassium channel activator (EC50=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-53347902. CAS No. 1401242-74-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12343. | |
| ML-290 | ML-290 is a first-in-class and potent relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 is a biased allosteric agonist at the relaxin receptor RXFP1. Uses: Scientific research. Group: Signaling pathways. CAS No. 1482500-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112606. | |
| ML 297 | ML 297 (VU 0456810) is a potent and selective GIRK 1/2 activator, with an EC 50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110192. | |
| ML 315 hydrochloride | ML 315 is a selective dual inhibitor of CDK and DYRK with IC 50 s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172559-91-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117608A. | |
| ML-323 | ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1572414-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17543. | |
| ML324 | ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 ?M. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222800-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12725. | |
| ML329 | ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 19992-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101464. | |
| ML334 | ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 ?M. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LH601A. CAS No. 1432500-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110258. | |
| ML336 | ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613465-33-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12928. | |
| ML339 | ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes ?-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 ?M and 1.4 ?M, respectively. ML339 shows weaker activity against the recruitment of ?-arrestin in mouse CXCR6 receptors, with an IC50 of 18 ?M. ML339 has no inhibitory effect on CXCR5?CXCR4?CXCR6 and apelin receptor (APJ), with IC50 >79 ?M. ML339 has the potential to promote the development of prostate cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2579689-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122197. | |
| ML346 | ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 ?M for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100872-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18669. | |
| ML347 | ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-?1[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDN 193719. CAS No. 1062368-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12274. | |
| ML348 | ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GNF-Pf-1127. CAS No. 899713-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100736. | |
| ML349 | ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890819-86-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100737. | |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| ML355 | ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 ?M, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. Uses: Scientific research. Group: Signaling pathways. CAS No. 1532593-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12341. | |
| ML364 | ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 ?M) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 ?M), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1991986-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100900. | |
| ML385 | ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 846557-71-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100523. | |
| ML390 | ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2029049-79-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100688. | |
| ML402 | ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 298684-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104027. | |
| ML-60218 | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 ?M for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 577784-91-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122122. | |
| ML-792 | ML-792 is a potent and selective inhibitor of SAE/SUMO1 and SAE/SUMO2 in enzymatic assays (IC50 values of 3 and 11 nM, respectively) compared with NAE/NEDD8 and UAE/ubiquitin (IC50> values of 32 ?M and >100 ?M, respectively)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1644342-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108702. | |
| ML-7 hydrochloride | ML-7 hydrochloride is a naphthalene sulphonamide derivative, potently inhibits MLCK ( IC 50 =300 nM). ML-7 hydrochloride also inhibits YAP/TAZ. Uses: Scientific research. Group: Signaling pathways. CAS No. 110448-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15417. | |
| ML-9 | ML-9 is a selective and potent inhibitor of Akt kinase , inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity [3]. ML-9 inhibits inhibits MLCK, PKA and PKC activity with K i values of 4, 32 and 54 μM, respectively [1]. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 105637-50-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-100932. | |
| MLCK inhibitor peptide 18 | MLCK inhibitor peptide 18 is a myosin light chain kinase ( MLCK ) inhibitor with an IC 50 of 50 nM, and inhibits CaM kinase II only at 4000-fold higher concentrations. Uses: Scientific research. Group: Peptides. CAS No. 224579-74-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1029. | |
| MLi-2 | MLi-2 is an orally active and highly selective LRRK2 inhibitor with an IC50 of 0.76 nM. MLi-2 has the potential for Parkinsons disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1627091-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100411. | |
| MLN0905 | MLN0905 is a potent, orally active Polo-like kinase 1 (PLK1) inhibitor. MLN0905 has inhibitory potency against PLK1 with an IC50 value of 2 nM. MLN0905 can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228960-69-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15155. | |
| MLN120B | MLN120B (ML120B) is a potent, ATP competitive, and orally active inhibitor of IKK? with an IC50 of 60 nM. MLN120B inhibits multiple myeloma cell growth in vitro and in vivo and also can be used for the research of rheumatoid arthritis[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML120B. CAS No. 783348-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15473. | |
| MLN-4760 | MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 ?M) and bovine carboxypeptidase A (CPDA; IC50, 27 ?M). Uses: Scientific research. Group: Signaling pathways. CAS No. 305335-31-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19414. | |
| MLN8054 | MLN8054 is a potent, selective and orally available aurora A kinase inhibitor with an IC 50 of 4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 869363-13-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10180. | |
| MLS0315771 | MLS0315771 is a potent and biologically active competitive phosphomannose isomerase (MPI) inhibitor, with an IC50 ~1 ?M and a Ki of 1.4 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 727664-91-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112945. | |
| ML-SA1 | ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 ?M and 52.99 ?M, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 332382-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108462. | |
| ML-SA5 | ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2418670-70-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152182. | |
| ML-SI1 | ML-SI1, a racemic mixture of diastereomers, is a TRPML inhibitor with an IC50 value of 15 ?M for TRPML1[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134818. | |
| ML-SI3 | ML-SI3 is a mixture of cis/trans ML-SI3 (HY-139426A), which is a TRPML1/2 channel inhibitor with IC50s of 4.7 ?M and 1.7 ?M, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 (HY-139426A) components of ML-SI3 are TRPML2 activators with EC50s of 3.3 ?M and 9.4 ?M, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-SI3 (cis/trans mix). CAS No. 891016-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139426. | |
| MM0299 | MM0299 is an inhibitor for lanosterol synthase (LSS) with an IC50 of 2.2 ?M. MM0299 inhibits cell proliferation of Mut6 with an IC50 of 0.0182 ?M, through generation of 24(S),25-epoxycholesterol (EPC) and the depletion of cellular cholesterol[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 474255-10-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160972. | |
| MM 07 | MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart. Uses: Scientific research. Group: Peptides. CAS No. 1876450-21-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-108003. | |
| MM-102 | MM-102 (HMTase Inhibitor IX) is a cell-permeable and tightly binding inhibitor of MLL1-WDR5 interaction (IC50=2.4 nM). MM-102 can specifically inhibit the growth and induce apoptosis of leukemia cells containing MLL1 fusion protein, and reduce renal fibrosis and inflammation in mice with ischemia-reperfusion injury. In addition, MM-102 also acts as an H3K4 histone methyltransferase inhibitor to improve the development of porcine somatic cell nuclear transfer (SCNT) embryos[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HMTase Inhibitor IX. CAS No. 1417329-24-8. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12220. | |
| MM11253 | MM11253 is a potent and selective RAR? antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RAR?, RAR? and RXR?. MM11253 blocks the growth inhibitory effects of RAR?-selective agonists[1][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 345952-44-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108530. | |
| MM-401 TFA | MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity ( IC 50 = 0.32 μM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1442106-11-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-19554A. | |
| MM 54 | MM 54 (compound 5) is a competitive antagonist at APJ , with an IC 50 of 93 nM. MM 54 behaves as a potent and selective inhibitor of apelin binding and APLNR activation [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 1313027-43-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2271. | |
| MMAE-d8 | MMAE-d 8 is a deuterated labeled MMAE, a potent mitotic inhibitor and a tubulin inhibitor. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Monomethyl auristatin E-d8; Deuterated labeled MMAE. CAS No. 2070009-72-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-15162A. | |
| MMAF | MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Monomethylauristatin F. CAS No. 745017-94-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15579. | |
| MMAI | MMAI is a selective serotonin releaser that can be used in the research of mental illnesses [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-Methoxy-6-methyl-2-aminoindan. CAS No. 136468-19-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W100249. | |
| MMG-11 | MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7?μM for Pam3CSK4-induced hTLR2/1 and 5.7?μM for Pam2CSK4-induced hTLR2/6 responses[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313254-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112146. | |
| MMP2-IN-3 | MMP2-IN-3 (compound 2) is a potent MMP-2 (matrix metalloproteinases) inhibitor, with an IC 50 of 31 μM. MMP2-IN-3 also shows inhibitory activity against MMP-9 and MMP-8 , with IC 50 values of 26.6, and 32 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 897799-81-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-147746. | |
| MMP-2/MMP-9-IN-1 | MMP-2/MMP-9-IN-1 is a highly selective, orally active and potent type IV collagenase ( MMP-9 and MMP-2 ) inhibitor with IC 50 s of 0.24 and 0.31 μM for MMP-9 and MMP-2, respectively. MMP-2/MMP-9-IN-1 is orally active in animal models of tumor growth and metastasis. MMP-2/MMP-9-IN-1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 193807-58-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116399. | |
| MMP-7-IN-2 | MMP-7-IN-2 is a potent and selective inhibitor of MMP7 with an IC50 value of 16 nM. MMP-7-IN-2 can be used for the research of diseases such as cancer and fibrosis[1]. Uses: Scientific research. Group: Peptides. CAS No. 2848717-49-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153563. | |
| MMP-9-IN-1 | MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 502887-71-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135232. | |
| MMP-9-IN-9 | MMP-9-IN-9 (compound 4f) is a slective MMP-9 inhibitor with an IC 50 of 5 nM. MMP-9-IN-9 shows selective for MMP-9 over MMP-1 and MMP-13. MMP-9-IN-9 shows strong anti-inflammatory and neuroprotective effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 206549-55-5. Pack Sizes: 500 μg. Product ID: HY-116302. | |
| MMP Inhibitor II | MMP Inhibitor II (compound 4e) is a potent, reversible pan- MMP inhibitor with IC 50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203915-59-7. Pack Sizes: 1 mg. Product ID: HY-119423. | |
| MMPIP hydrochloride | MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 ( mGluR7 ) selective antagonist ( K B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1215566-78-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103111. | |
| MMPSI | MMPSI is a potent and selective small molecule caspase 3 and caspase 7 inhibitor with an IC 50 of 1.7 μM for human caspase-3. MMPSI can significantly reduce ischemia-reperfusion-induced infarct size in the isolated rabbit heart, and reduce apoptosis in both the ischemic myocardium and isolated cardiomyocytes. MMPSI can be used for researching cardioprotection [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 220509-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103346. | |
| MMs02943764 | MMs02943764 is a 1,2,4-triazole derivative with anticancer activity. MMs02943764 has significant antiproliferative effects on multiple cancer cell lines. PAC, a structural analog of MMs02943764, has significant cytotoxicity against the leukemia cell line K562 ( IC 50 =35.264 μM), reduces the degradation of p53 by inhibiting Mdm2 and Pirh2 , and induces K562 cell cycle arrest [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 708287-29-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158968. | |
| MMV688533 | MMV688533 is an antimalarial agent with rapid anti-plasmodial activity and effective single-dose activity against Plasmodium falciparum infection in humanized mouse models. MMV688533 can inhibit the activity of asexual blood stage parasites with an IC 50 value of 1.3 nM. MMV688533 exhibits excellent pharmacokinetic properties and safety [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2260904-47-8. Pack Sizes: 1 mg. Product ID: HY-148178. | |
| MN58b | MN58b is a selective choline kinase ? (CHK?) inhibitor, and results in inhibition of phosphocholine synthesis. MN58b reduces cell growth through the induction of apoptosis, and also has antitumoral activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 203192-01-2. Pack Sizes: 1 mg. Product ID: HY-108431. | |
| MNI-caged-L-glutamate | MNI-caged-L-glutamat is a reagent that can release neuroactive amino acids quickly and efficiently [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 295325-62-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-107520. | |
| m-Nifedipine | m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21881-77-6. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-135356. | |
| MNITMT | MNITMT is a more potent immunosuppressive agent without bone marrow toxicity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 177653-76-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110044. | |
| MNS | MNS (NSC 170724), the beta-nitrostyrene derivative, is an orally active tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. MNS inhibits Src, Syk, and FAK with IC 50 of 27.3, 2.8, and 97.6 μM, respectively. MNS inhibits NLRP3 inflammasome and β1 integrin. MNS completely inhibits U46619, ADP-, arachidonic acid-, collagen-, and thrombin-induced platelet aggregation with IC 50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM, respectively. MNS is cytotoxic to a variety of cells [1] [2] [3] [4] [5] [6] [7] [8] [9]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 170724; 5-(2-Nitrovinyl)benzodioxole. CAS No. 1485-00-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg. Product ID: HY-78263. | |
| MnTBAP chloride | MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NF?B signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 55266-18-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126397. | |
| Mobocertinib | Mobocertinib (TAK-788) is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib can be used in NSCLC research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-788; AP32788. CAS No. 1847461-43-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-135815. | |
| Mobocertinib succinate | Mobocertinib (TAK-788) succinate is an orally active and irreversible EGFR/HER2 inhibitor. Mobocertinib succinate potently inhibits oncogenic variants containing activating EGFRex20ins mutations with selectivity over wild-type EGFR. Mobocertinib succinate can be used in NSCLC research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-788 succinate; AP32788 succinate. CAS No. 2389149-74-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-135815A. | |
| MOBS | MOBS is an amphoteric buffer, a butane analogue of the Good buffers MOPS [3-(N-morpholino) propanesulfonic acid] and MES [2-(N-morpholino) ethanesulfonic acid] [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 115724-21-5. Pack Sizes: 5 g; 25 g. Product ID: HY-W127629. | |
| Mocetinostat | Mocetinostat (MGCD0103) is a potent, orally active and isotype-selective HDAC (Class I/IV) inhibitor with IC 50 s of 0.15, 0.29, 1.66 and 0.59 μM for HDAC1 , HDAC2 , HDAC3 and HDAC11 , respectively. Mocetinostat shows no inhibition on HDAC4, HDAC5, HDAC6, HDAC7, or HDAC8. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MGCD0103. CAS No. 726169-73-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12164. | |
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