MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| MRTX1133 | MRTX1133 is a noncovalent, potent, and selective alkyne-based KRAS G12D inhibitor. MRTX1133 optimally fills the switch II pocket and extends three substituents to favorably interact with the protein, resulting in an estimated KD against KRAS G12D of 0.2 pM. MRTX1133 prevents SOS1-catalyzed nucleotide exchange and/or formation of the KRAS G12D/GTP/RAF1 complex, thereby inhibiting mutant KRAS-dependent signal transduction. MRTX1133 selectively inhibits KRAS G12D mutant, but not KRAS wild-type, tumor cells. MRTX1133 has single digit nanomolar activity in cellular assays and marked in vivo efficacy in tumor models harboring KRAS G12D mutations[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2621928-55-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-134813. |  |
| MRX-2843 | MRX-2843 (UNC2371) is an orally active, ATP-competitive dual MERTK and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC50s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UNC2371. CAS No. 1429882-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101549. | |
| MS023 | MS023 is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1831110-54-3. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1992047-64-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19615B. | |
| MS15 | MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC 50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035638-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-151613. | |
| MS170 | MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC 50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with K d s of 1.3 nM, 77 nM, and 6.5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376136-61-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145282. | |
| MS177 | MS177 is an effective and fast-acting EZH2 degrader. MS177 is a PROTAC that consists of a CRBN ligand, linker, and a potent enzymatic EZH2 inhibitor C24 (C24 IC50): 12 nM). MS177 effectively depletes both canonical EZH2-PRC2 and noncanonical EZH2-cMyc complexes. MS177 induces leukaemia cell growth inhibition, apoptosis and cell cycle progression arrest[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225938-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148333. | |
| MS1943 | MS1943 is an orally active, PROTAC-based, selective degrader of EZH2 that effectively reduces EZH2 levels in cells. MS1943 has anticancer activity and exhibits cytotoxic effects in a variety of TNBC cells while sparing normal cells. In addition, MS1943 maintains high potency (IC50=120 nM) in inhibiting EZH2 methyltransferase activity and is highly selective for EZH2. (Structure Note: RED, EZH2 ligand (HY-148458); Blue, Hyt (HY-W001578))[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2225938-17-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-133129. | |
| MS21 | MS21, a novel degrader of AKT , selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376137-05-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141807. | |
| MS39 | MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2675490-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157581. | |
| MS4078 | MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19?nM for binding affinity to ALK[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2229036-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112155. | |
| MS41 | MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC 50 s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768610-97-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-169093. | |
| MS432 | MS432 is a first-in-class and highly selective PD0325901-based von Hippel-Lindau-recruiting PROTAC degrader for MEK1 and MEK2. MS432 displays good plasma exposure in mice, exhibiting DC50 values of 31 nM and 17 nM for MEK1, MEK2 in HT29 cells respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2672512-44-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130602. | |
| MS4322 | MS4322 (YS43-22) is a specific PRMT5 PROTAC degrader. MS4322 reduces the PRMT5 protein level with a DC50 of 1.1 ?M in MCF-7 cells. MS4322 inhibits the methyltransferase activity of PRMT5 with an IC50 of 18 nM. MS4322 promotes ubiquitination and degradation of PRMT5. MS4322 can be used for the research of breast cancer, lung cancer, and hepatocellular cancer. (Pink: PRMT5 ligand (HY-173092); Blue: E3 ligase ligand HY-112078); Black: linker (HY-124780); E3+linker (HY-173093 ))[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: YS43-22. CAS No. 2375432-47-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-141877. | |
| MS438 | MS438 is a potent thyrotropin receptor ( TSHR ) agonist with an EC 50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 512840-45-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-114918. | |
| MS-444 | MS-444 inhibits the activity of purified smooth muscle myosin light chain kinase (MLCK) with an IC50 value of 10 ?M. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BE-34776. CAS No. 150045-18-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100685. | |
| MS67 | MS67 is a potent and selective WD40 repeat domain protein 5 (WDR5) degrader with a Kd of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407452-77-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141796. | |
| MS8709 | MS8709 (compound 10), a potential anticancer therapeutic, is a first-in-class G9a/GLP PROTAC degrader. MS8709 is based on G9a/GLP inhibitor UNC0642 and recruits the von Hippel Lindau (VHL) E3 ligase (Red: G9a/GLP inhibitor UNC0642; Blue: VHL ligand; Black: linker)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3060730-06-2. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-162362. | |
| MS934 | MS934 is a novel improved VHL-recruiting MEK 1/2 PROTAC degrader. MS934 also degrades CRAF. MS934 can be used for the research of variety of human cancers, such as melanoma, nonsmall cell lung cancer (NSCLC), colorectal cancer, primary brain tumors, and hepatocellular carcinoma (Pink: Target protein ligand (HY-168288); Black: linker (HY-168289); Blue: E3 ligase ligand (HY-112078))[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2756323-15-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153863. | |
| MSA-2 | MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 ?M for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-? secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129425-81-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-136927. | |
| MSAB | MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173436-66-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120697. | |
| MSBN | MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 135980-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119493. | |
| MSC1094308 | MSC1094308 is a non-competitive and reversible VPS4B/p97 (VCP) (I/II type AAA ATPase) allosteric inhibitor, with IC50 values of 0.71 ?M and 7.2 ?M for VPS4B and p97, respectively[1]. MSC1094308 inhibits the D2 ATPase activity by binding to a agentable hotspot of p97. MSC1094308 can be used in study of cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2219320-08-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123872. | |
| MSC2530818 | MSC2530818 is a potent, selective and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883423-59-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101611. | |
| MSC-4381 | MSC-4381 (MCT4-IN-1) is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC 50 of 77 nM and a K i of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research [1]. MSC-4381 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MCT4-IN-1. CAS No. 2445185-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132301. | |
| MSDC 0160 | MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimers disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mitoglitazone; CAY10415. CAS No. 146062-49-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100550. | |
| MSG606 | MSG606 is a selective MC1R (melanocortin 1 receptor) antagonist and can be used for the research of neuroprotective effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1416983-77-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1726. | |
| MSI-1436 | MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B) , with an IC 50 of appr 1 μM, 200-fold preference over TCPTP (IC 50 , 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine; Aminosterol-1436. CAS No. 186139-09-3. Pack Sizes: 500 μg. Product ID: HY-12219. | |
| MSI-1436 lactate | MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B ( PTP1B ), with an IC 50 of 1 μM, 200-fold preference over TCPTP ( IC 50 of 224 μM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: Trodusquemine lactate; Aminosterol-1436 lactate. CAS No. 1309370-86-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12219A. | |
| mSIRK | mSIRK (G-Protein ?? Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 ?M. mSIRK disrupts the interaction between ? and ?? subunits and promotes ? subunit dissociation without stimulating nucleotide exchange[1]. Uses: Scientific research. Group: Peptides. CAS No. 593267-11-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P5985. | |
| MSN-125 | MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 ?M. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1592908-16-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-120079. | |
| MSN-50 | MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1592908-75-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118948. | |
| MSNBA | MSNBA is a specific inhibitor of GLUT5 fructose transport in proteoliposomes. MSNBA competitively inhibits GLUT5 fructose uptake with a K I of 3.2±0.4 μM in MCF7 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 852702-51-3. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W179181. | |
| MSOP | MSOP is a selective group III metabotropic glutamate receptor antagonist with apparent K D of 51 μM for the L-AP4-sensitive presynaptic mGluR. Uses: Scientific research. Group: Signaling pathways. CAS No. 66515-29-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101226. | |
| MSP-3 | MSP-3 is a potent TRPV1 agonist, with an EC 50 of 0.87 μM. MSP-3 exhibits neuroprotective and antinociceptive effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820968-63-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118785. | |
| MSPC | MSPC is an asymmetrical phosphatidylcholine containing a myristic acid (14:0) at the sn-1 position and a stearic acid (18:0) at the sn-2 position. It can self assemble in water to form lipid bilayers. Reagent grade, for research purpose. Uses: Scientific research. Group: Natural products. Alternative Names: PC(14:0/18:0); 1-Myristoyl-2-stearoyl-sn-glycero-3-phosphocholine. CAS No. 76343-22-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W019833. | |
| Msr-Ratio | Msr-Ratio (Msr-green) is a ratiometric fluorescent probe of methionine sulfoxide reductase (λex=375 nm, λem=550 nm). Msr-Ratio is used for monitoring the enzyme activity in vitro and in live cells [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Msr-green. CAS No. 2290635-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-D1257. | |
| MST-312 | MST-312 is a telomerase inhibitor. MST-312 is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). MST-312 can be used for the research of cancer, such as multiple myeloma (MM)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Telomerase Inhibitor IX. CAS No. 368449-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120145. | |
| MSU38225 | MSU38225 is an Nrf-2 inhibitor that increases levels of reactive oxygen species (ROS). MSU38225 inhibits the growth of human lung cancer cells and enhances the sensitivity of human lung cancer cells to chemotherapy in vitro and in vivo. MSU38225 can be used in cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1629160-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-153873. | |
| MT1 | MT1 is a bivalent chemical probe of BET bromodomains , with an IC 50 of 0.789 nM for BRD4(1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2060573-82-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111976. | |
| MT-1207 | MT-1207 is an orally active and selective adrenergic α 1 and 5-HT 2A receptor antagonist. MT-1207 shows IC 50 <0.1 nM, 0.15 nM, 1.40 nM and 0.27 nM for α 1A , α 1B , α 1D and 5-HT 2A , respectively. MT-1207 achieves an effective blood pressure (BP) reduction in the 2K2C rat model without damaging renal function. MT-1207 is a potent multitarget inhibitor with the potential for vasodilatation research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1610794-70-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162677. | |
| MT-4 | MT-4 is a derivative of a tissue transglutaminase ( TG2 ) inhibitor. MT-4 targets the complex of TG2 and fibronectin (FN) (TG2/FN) and inhibits the adhesion of tumor cells to the matrix. MT-4 inhibits the adhesion of ovarian cancer (OC) cells to the peritoneum and increases the sensitivity of OC cells to paclitaxel. Uses: Scientific research. Group: Signaling pathways. CAS No. 2327925-35-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128595. | |
| MTBT | MTBT is an anticancer agent and p38 activator with antiproliferative and apoptosis-inducing ( apoptosis ) activities. MTBT increases the phosphorylation of histone H3 serine in cancer cells, thereby arresting the cell cycle in the M phase. SB203580 (HY-10256), a specific inhibitor of p38 MAPK, abolished MTBT-induced cell cycle arrest [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1110905-26-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-118034. | |
| MT-DADMe-ImmA | MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a Ki of 90 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MTDIA; Methylthio-DADMe-Immucillin A. CAS No. 653592-04-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101496. | |
| MTEP hydrochloride | MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC 50 of 5 nM and a K i of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13206. | |
| MTIC | MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3413-72-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119696. | |
| MTK458 | MTK458 is an orally active brain penetrant PINK1 activator. MTK458 binds to PINK1 and stabilizes an active heterocomplex, thereby increasing mitophagy. MTK458 can be used for research on Parkinson's disease[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EP-0035985. CAS No. 2499962-58-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-152943. | |
| m-Tolualdehyde | m-Tolualdehyde (3-Methylbenzaldehyde) is a compound that can be isolated from Ficus carica L. and Myosotis arvensis. m-Tolualdehyde has food protective effects. m-Tolualdehyde shows acaricidal activities for Tyrophagus putrescentiae with a LD 50 of 1.97?μg/cm 3 [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Methylbenzaldehyde. CAS No. 620-23-5. Pack Sizes: 10 mM * 1 mL; 5 g. Product ID: HY-78086. | |
| mTOR inhibitor-1 | mTOR inhibitor-1 (Compound C-4) is an ATP-Competitive mTOR inhibitor which can suppress cells proliferation and inducing autophagy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 468747-17-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112914. | |
| mTOR inhibitor-3 | mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments. Uses: Scientific research. Group: Signaling pathways. CAS No. 1207358-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18353. | |
| MTSEA hydrobromide | MTSEA hydrobromide is a sulfhydryl-reactive compound that modifies free cysteine residues to produce a positively charged side chain approximately the size of lysine [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 16599-33-0. Pack Sizes: 10 mg. Product ID: HY-120128. | |
| MTX115325 | MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2750895-97-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-160019. | |
| MTX-23 | MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PROTAC AR-V7 degrader-2. CAS No. 2488296-74-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148771. | |
| MTX-531 | MTX-531 is an oral drug that inhibits EGFR (with an IC 50 of 14.7 nM) and PI3K (with IC 50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα , PI3Kβ , PI3Kγ , and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ , with an IC 50 of 2.5 μM, helping to alleviate hyperglycemia induced by PI3K inhibitors [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2791417-66-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162713. | |
| m-Tyramine hydrobromide | m-Tyramine hydrobromide is an endogenous trace amine neuromodulator. m-Tyramine hydrobromide has effects on the adrenergic and dopaminergic receptor [1, 2]. Uses: Scientific research. Group: Natural products. CAS No. 38449-59-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-128975. | |
| MU1742 | MU1742 is a probe for CK1? and CK1? protein kinases[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg. Product ID: HY-148251. | |
| Mubritinib | Mubritinib (TAK-165) is a potent and selective EGFR2/HER2 inhibitor with an IC 50 of 6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-165. CAS No. 366017-09-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13501. | |
| MUC1, mucin core | MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 [1]. Uses: Scientific research. Group: Peptides. CAS No. 149205-73-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P2508. | |
| Mucic acid | Mucic acid is an endogenous metabolite. Uses: Scientific research. Group: Natural products. CAS No. 526-99-8. Pack Sizes: 10 mM * 1 mL; 50 g. Product ID: HY-W014410. | |
| Mucicarmine | Mucicarmine is used in the histological visualization of acid mucopolysaccharides in tissue sections. Mucicarmine can identify mucin (deep rose), which is useful in determining the mucin positive cancer (such as liver carcinoma) [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 51395-97-2. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-D1542. | |
| Mufemilast | Mufemilast is a phosphodiesterase 4 (PDE4) inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Hemay005. CAS No. 1255909-03-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-145583. | |
| Mulberroside A | Mulberroside A is one of the main bioactive constituent in mulberry ( Morus alba L.) [1]. Mulberroside A decreases the expressions of TNF-α , IL-1β , and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects [2]. Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC 50 of 53.6 μM [3]. Uses: Scientific research. Group: Natural products. CAS No. 102841-42-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-N0619. | |
| Mumeose K | Mumeose K is the inhibitor for aldose reductase with an IC 50 of 27 μM. Mumeose K exhibits potential anti-diabetic activity, and can be used in research about diabetes-related complication [1]. Uses: Scientific research. Group: Natural products. CAS No. 2132384-01-9. Pack Sizes: 1 mg. Product ID: HY-N13759. | |
| Mupadolimab | Mupadolimab (CPI-006) is an IgG1κ humanized FcγR binding-deficient anti- CD73 monoclonal antibody (mAb) that activates CD73 POS B cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: CPI-006. CAS No. 2451856-97-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99181. | |
| Mupirocin | Mupirocin (BRL-4910A, Pseudomonic acid) is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: BRL-4910A; Pseudomonic acid. CAS No. 12650-69-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0958. | |
| Mupirocin calcium hydrate | Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: BRL-4910A calcium hydrate; Pseudomonic acid calcium hydrate. CAS No. 115074-43-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N7068. | |
| Mupirocin lithium | Mupirocin (BRL-4910A) lithium is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin lithium apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BRL-4910A lithium; Pseudomonic acid lithium. CAS No. 73346-79-9. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W108875. | |
| Muramic acid | Muramic acid is a component in many Gram-positive bacterial cell walls, as marker for Gram-positive bacteria [1]. Uses: Scientific research. Group: Natural products. CAS No. 1114-41-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W011916. | |
| Muramyl dipeptide | Muramyl dipeptide (MDP) is a synthetic immunoreactive peptide , consisting of N-acetyl muramic acid attached to a short amino acid chain of L-Ala-D-isoGln. Muramyl dipeptide is an inducer of bone formation through induction of Runx2. Muramyl dipeptide directly enhances osteoblast differentiation by up-regulating Runx2 gene expression through MAPK pathways. Muramyl dipeptide is a NLRP1 agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MDP. CAS No. 53678-77-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127090. | |
| Murepavadin TFA | Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: POL7080 TFA. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-P1674A. | |
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