MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| MitoTEMPO hydrate | Mito-TEMPO is a mitochondria-targeted antioxidant that possesses superoxide and alkyl radical scavenging properties. Mito-TEMPO helps protect against oxidative damage to the mitochondria [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1569257-94-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125944. |  |
| MitoTEMPOL | MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2 - to H2O2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1101113-39-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-115386. | |
| MitoTracker Deep Red FM | MitoTracker Deep Red (MTDR) FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 644/665 nm[1]. MitoTracker Deep Red dyes have an excitation/emission wavelength of 633/650-750 nm[2].The Ex/Em of MitoTracker Deep Red (MTDR) FM is 644/665 nm. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: MTDR FM. CAS No. 873315-86-7. Pack Sizes: 50 ?g; 100 ?g. Product ID: HY-D1783. | |
| MitoTracker Green FM | Mito-Tracker Green is a green fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Green FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 490/523 nm. Uses: Scientific research. Group: Fluorescent dye. CAS No. 201860-17-5. Pack Sizes: 50 ?g. Product ID: HY-135056. | |
| Mitoxantrone | Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity [1] [2] [3] [4]. Mitoxantrone also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Mitozantrone; NSC 301739. CAS No. 65271-80-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13502. | |
| Mitoxantrone dihydrochloride | Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C ( PKC ) activity with an IC 50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity [1] [2] [3] [4]. Mitoxantrone dihydrochloride also has anti- orthopoxvirus activity with EC 50 s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively [5]. Uses: Scientific research. Group: Natural products. Alternative Names: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride. CAS No. 70476-82-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13502A. | |
| Mitraphylline | Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils [1]. Uses: Scientific research. Group: Natural products. CAS No. 509-80-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6946. | |
| Mivacurium dichloride | Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 106861-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1700A. | |
| Mivebresib | Mivebresib (ABBV-075) is a potent and orally active bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a K i of 1.5 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABBV-075. CAS No. 1445993-26-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100015. | |
| Mizacorat | Mizacorat (AZD9567; compound 15) is a potent, oral active, non-steroidal and selective glucocorticoid receptor modulator (SGRM), with an IC50 of 3.8 nM. Exhibits excellent efficacy in the streptococcal cell wall (SCW) reactivation model of joint inflammation[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD9567. CAS No. 1893415-00-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-120012. | |
| Mizagliflozin | Mizagliflozin (DSP-3235 free base) is a potent, orally active and selective SGLT1 inhibitor, with a K i of 27 nM for human SGLT1. Mizagliflozin displays 303-fold selectivity over SGLT2. Mizagliflozin is used as an antidiabetic agent that can modify postprandial blood glucose excursion. Mizagliflozin also exhibits potential in the amelioration of chronic constipation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DSP-3235 free base; KGA-3235 free base; GSK-1614235 free base. CAS No. 666843-10-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17638. | |
| Mizolastine | Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165 , VEGF120 , TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 108612-45-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-B0164. | |
| Mizoribine | Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC 50 of approximately 100 μM for anti-HCV activity. Immunosuppressant [1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC 50 s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively [2]. Uses: Scientific research. Group: Natural products. Alternative Names: NSC 289637; HE 69. CAS No. 50924-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17470. | |
| MJN110 | MJN110 is an orally active and selective monoacylglycerol lipase (MAGL) inhibitor with IC50s of 9.1 nM and 2.1 nM for hMAGL and 2-arachidonoylglycerol (2-AG), respectively[1]. MJN110 produces opioid-sparing effects and displays strong antihyperalgesic activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1438416-21-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117474. | |
| MJN228 | MJN228 is a lipid-binding protein nucleobindin-1 ( NUCB1 ) inhibitor with an IC 50 of 3.3 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 459168-97-9. Pack Sizes: 1 mg. Product ID: HY-118319. | |
| MK-0159 | MK-0159 is an orally active, potent and selective CD38 inhibitor, with IC50 values of 22, 3, and 70 nM for human, mouse and rat CD38, respectively. MK-0159 also shows good microsomal stability for human and rodent liver microsomes. MK-0159 increases NAD+ (nicotinamide adenine dinucleotide) and reduces ADPR (adenosine diphosphate ribose) in whole blood and heart[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641484-61-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150508. | |
| MK-0429 | MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for ?v?1, ?v?3, ?v?5, ?v?6, ?v?8 and ?5?1, respectively[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-000845704. CAS No. 227963-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15102. | |
| MK-0493 | MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R) , demonstrating significant reductions in energy intake [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 455956-93-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118930. | |
| MK-0493 hydrochloride | MK-0493 hydrochloride is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R) , demonstrating significant reductions in energy intake [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 455957-71-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-118930A. | |
| MK-0731 | MK-0731 is a selective, non-competitive and allosteric kinesin spindle protein (KSP) inhibitor with an IC50 of 2.2 nM and a pKa of 7.6. MK-0731 is >20,000 fold selectivity against other kinesins. MK-0731 induces mitotic arrest and induces apoptosis in tumors. MK-0731 provides significant antitumor efficacy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 845256-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-50672. | |
| MK-0752 | MK-0752 is a potent, orally active and specific ?-secretase inhibitor, showing dose-dependent reduction of A?40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS A? in vivo[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 471905-41-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10974. | |
| MK 0893 | MK 0893 is a potent and selective glucagon receptor antagonist with an IC50 of 6.6 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 870823-12-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50663. | |
| MK-1084 | MK-1084 is a selective KRAS G12C inhibitor that is currently in Phase I clinical trial (NCT05067283). MK-1084 exhibits anticancer activity and can be used either alone or in combination with pembrolizumab (HY-P9902) for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2641216-67-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-162431. | |
| MK-2206 | MK-2206 is an orally active, highly potent and selective allosteric Akt inhibitor, with IC 50 s of 8, 12, and 65 nM for Akt1, Akt2, and Akt3, respectively. Many breast cancer cell lines, and PIK3CA-mutant and cell lines with PTEN loss are sensitive to MK-2206. MK-2206 has anticancer activities [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1032349-77-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108232. | |
| MK-2206 dihydrochloride | MK-2206 dihydrochloride (MK-2206 (2HCl)) is an orally active, BBB-penetrated allosteric AKT inhibitor with IC 50 s of 5 nM, 12 nM, and 65 nM for AKT1 , AKT2 , and AKT3 , respectively. MK-2206 dihydrochloride induces autophagy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-2206 (2HCl). CAS No. 1032350-13-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10358. | |
| MK-28 | MK-28 is a potent and selective PERK activator. MK-28 exhibits remarkable pharmacokinetic properties and high BBB penetration in mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 864388-65-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-137207. | |
| MK-3207 | MK-3207 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor : IC 50 =0.12 nM; K i =0.024 nM). MK-3207 can be used for migraine studies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 957118-49-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-10301. | |
| MK-3207 Hydrochloride | MK-3207 (Hydrochloride) is a potent and orally bioavailable CGRP receptor antagonist with IC 50 of 0.12 nM and K i of 0.024 nM, and is highly selective versus human AM1, AM2, CTR, and AMY3. Uses: Scientific research. Group: Signaling pathways. CAS No. 957116-20-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-10302. | |
| MK-4074 | MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC50 values of approximately 3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1039758-22-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107709. | |
| MK-4256 | MK-4256 is a potent and selective SSTR3 antagonist with IC50s of 0.66 nM and 0.36 nM in human and mouse receptor binding assays, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1104599-69-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13466. | |
| MK-5046 | MK-5046 is a potent, selective and orally active Bombesin receptor subtype-3 (BRS-3) allosteric agonist with an IC50 and an EC50 value of 27 and 25 nM for hBRS-3, respectively. MK-5046 inhibits food intake and reduces body weight of diet-induced obese (DIO) mouse models. MK-5046 can be used for the research of obesity[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1022152-70-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14342. | |
| MK-5108 | MK-5108 is a highly potent and specific inhibitor of Aurora A kinase with an IC50 value of 0.064 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-689. CAS No. 1010085-13-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13252. | |
| MK-571 | MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711. CAS No. 115104-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19989. | |
| MK-571 sodium | MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1). MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-660711 sodium. CAS No. 115103-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19989A. | |
| MK-6240 | MK-6240 is a tau positron emission tomography (PET) tracer for neurofibrillary tangles (NFTs) , exhibiting high specificity and selectivity for binding to NFTs [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841078-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101186. | |
| MK6-83 | MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1062271-24-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110238. | |
| MK-6892 | MK-6892 is a potent, selective, and full agonist for the high affinity nicotinic acid (NA) receptor GPR109A. Ki and GTP?S EC50 of MK-6892 on the Human GPR109A is 4 nM and 16 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 917910-45-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10680. | |
| MK-761 free base | MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 65321-41-7. Pack Sizes: 1 mg. Product ID: HY-123449. | |
| MK-8189 | MK-8189 is a potent, orally active and selective PDE10A inhibitor with a K i value of 29 pM. MK-8189 can be used in research of schizophrenia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1424371-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153093. | |
| MK-8245 | MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC 50 s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1030612-90-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13070. | |
| MK-8245 Trifluoroacetate | MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415559-41-9. Pack Sizes: 1 mg. Product ID: HY-13077. | |
| MK-8353 | MK-8353 (SCH900353) is a potent, selective and orally available ERK1/2 inhibitor, with IC50s of 23.0 nM and 8.8 nM, respectively; MK-8353 has antitumor activity. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCH900353. CAS No. 1184173-73-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111407. | |
| MK-8527 | MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor ( NRTTI ) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810869-23-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158128. | |
| MK-8617 | MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. Uses: Scientific research. Group: Signaling pathways. CAS No. 1187990-87-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101023. | |
| MK8722 | MK8722 is a potent and systemic pan-AMPK activator. Uses: Scientific research. Group: Signaling pathways. CAS No. 1394371-71-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111363. | |
| MK-886 | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP ( IC 50 of 30 nM) and leukotriene biosynthesis ( IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L 663536. CAS No. 118414-82-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14166. | |
| MKC-1 | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro-31-7453. CAS No. 125313-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13691. | |
| MKC3946 | MKC3946 is a potent IRE1? inhibitor, used for cancer research. Uses: Scientific research. Group: Signaling pathways. CAS No. 1093119-54-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19710. | |
| MKC8866 | MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 ?M in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s) expression with an EC50 of 0.52 ?M and unstresses RPMI 8226 cells with an IC50 of 0.14 ?M[1]. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer (PCa) tumor growth[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Orin1001. CAS No. 1338934-59-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104040. | |
| MKI-1 | MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 ?M, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MASTL Kinase Inhibitor-1. CAS No. 1190277-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137552. | |
| MKT-077 | MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity[1]. MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm[2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: FJ-776. CAS No. 147366-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15096. | |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 ( MC4R ) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML095 | ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-25067483. CAS No. 1135318-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128000. | |
| ML-10 | ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18 F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216897-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76573. | |
| ML 10302 | ML 10302 is a potent agonist 5-HT4 receptor with K i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148868-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14441. | |
| ML115 | ML115 is a molecular probe of the signal transducer and activator of transcription ( STAT3 ). ML115 is a STAT3 agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111152. | |
| ML133 hydrochloride | ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML141 | ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 ?M, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-2950007. CAS No. 71203-35-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12755. | |
| ML162 | ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035072-16-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 1 g. Product ID: HY-100002. | |
| ML171 | ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 ?M in HEK293-Nox1 confirmatory assay. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 2-Acetylphenothiazine; 2-APT. CAS No. 6631-94-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-12805. | |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML-193 | ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC50 of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinsons disease (PD) rats[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 1261822. CAS No. 713121-80-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-110125. | |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| (±)-ML 209 | (±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC 50 of 1.1 μM. (±)-ML 209 inhibits RORγt transcriptional activity with an IC 50 of 300 nM in HEK293t cells. (±)-ML 209 inhibits the transcriptional activity of RORγt, but not RORα in cells. (±)-ML 209 selectively inhibits murine Th17 cell differentiation without affecting the differentiation of naïve CD4 + T cells into other lineages, including Th1 and regulatory T cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1334526-14-5. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126037. | |
| ML-210 | ML-210 is a selective and covalent glutathione peroxidase 4 (GPX4) inhibitor with an EC50 of 30 nM. ML-210 binds the GPX4 selenocysteine residue. ML-210 has anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1360705-96-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100003. | |
| ML213 | ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 489402-47-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101843. | |
| ML216 | ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 ?M and 0.97 ?M for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 ?M. Antitumor avtivity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-49852229. CAS No. 1430213-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12342. | |
| ML221 | ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 ?M in the cAMP assay, and 1.75 ?M in the ?-arrestin assay, and EC80 of 10 nM in both assays. Uses: Scientific research. Group: Signaling pathways. CAS No. 877636-42-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103254. | |
| ML228 | ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC50 of 1 ?M. ML228 potently activates HIF in vitro as well as its downstream target VEGF[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-46742353. CAS No. 1357171-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12754. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.