MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tafasitamab | Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigen CD19 [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: XmAb5574; MOR00208; Tafasitamab-cxix. CAS No. 1422527-84-1. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9981. |  |
| Tafenoquine | Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WR 238605. CAS No. 106635-80-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111529. | |
| Tafenoquine Succinate | Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WR 238605 Succinate. CAS No. 106635-81-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111529A. | |
| Tafetinib | Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibits stem cell factor receptor (Kit) , vascular endothelial growth factor receptor-2 (VEGFR-2) , platelet-derived growth factor receptor-β (PDGFR-β) , glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET) , and Fms-like tyrosine kinase-3 (FLT3) with IC 50 values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation of PDGFR-β and VEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SIM010603. CAS No. 1032265-57-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-116116. | |
| Tafluprost | Tafluprost (AFP-168) is an anti-glaucoma prostaglandin (PG) analog. Tafluprost can inhibit the apoptosis of retinal ganglion cells (RGCs) and rat RGCs cells. Tafluprost promotes axon regeneration by regulating Zn 2+ - mTOR pathway, inhibits intracellular lipid accumulation in human preorbital adipocytes. Tafluprost can be used in the study of optic nerve injury in glaucoma [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AFP-168; MK2452. CAS No. 209860-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0600. | |
| Tafluprost acid | Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with K i and EC 50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor ( IC 50 =67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AFP-172. CAS No. 209860-88-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0601. | |
| Tafolecimab | Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IBI-306. CAS No. 2225109-03-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99552. | |
| Tagarafdeg | Tagarafdeg (CFT1946) is an orally active, CRBN-based and mutant-selective bifunctional degradation activating compound (BiDAC) degrader of BRAFV600E with a DC50 of 14 nM in A375 cells. Tagarafdeg is capable of degrading BRAF V600E (Class I), G469A (Class II), G466V (Class III) mutations, and the p61-BRAFV600E splice variant. Tagarafdeg can be used in tumor research[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CFT1946. CAS No. 2882165-79-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-153341. | |
| Tagitanlimab | Tagitanlimab (HBM-9167) is a humanized anti-PD-L1 antibody (IgG1κ type). Tagitanlimab selectively blocks the interaction of PD-L1 and PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC) [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: HBM-9167; KL-A167. CAS No. 2417649-97-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99544. | |
| Tagtociclib hydrate | PF-07104091 hydrate is a potent and selective CDK2/cyclin E1 and GSK3? inhibitor, with Kis of 1.16 and 537.81 nM, respectively. PF-07104091 hydrate has anti-tumor activity for cyclin E1-amplified cancers. (patent WO2020157652A2). Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-07104091 hydrate. CAS No. 2733575-91-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137894A. | |
| TAK-071 | TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC 50 of TAK-071 M1R agonist activities is 520 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820812-16-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122190. | |
| TAK1-IN-2 | TAK1-IN-2 is a potent and selective TAK1 inhibitor, with an IC50> of 2 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2763213-98-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132172. | |
| TAK1-IN-3 | TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 494772-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115743. | |
| TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor ( IC 50 =1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN7243. CAS No. 1450833-55-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100487. | |
| TAK-418 | TAK-418 is a selective, orally active LSD1 (KDM1A) enzyme inhibitor with an IC50 of 2.9 nM. TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1818252-53-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-138830. | |
| TAK-441 | TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC 50 value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186231-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16475. | |
| TAK-632 | TAK-632 is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAFV600E, BRAFWT, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228591-30-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15767. | |
| TAK-715 | TAK-715 is an orally active and potent p38 MAPK inhibitor with IC50s of 7.1 nM, 200 nM for p38? and p38?, respectively. TAK-715 inhibits casein kinase I (CK1?/?) to regulate activation of Wnt/?-catenin signaling. TAK-715 shows good significant efficacy in a rat arthritis model[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 303162-79-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10456. | |
| TAK-733 | TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1035555-63-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13449. | |
| TAK-779 | TAK-779 is a potent and selective nonpeptide antagonist of CCR5 and CXCR3, with a Ki of 1.1 nM for CCR5, and effectively and selectively inhibits R5 HIV-1, with EC50 and EC90 of 1.2 nM and 5.7 nM, respectively, in MAGI-CCR5 cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Takeda 779. CAS No. 229005-80-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13406. | |
| TAK-960 | TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) , with an IC 50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC 50 s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137868-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15160. | |
| Takinib | Takinib (EDHS-206) is an orally active and selective TAK1 inhibitor (IC50=9.5 nM), more than 1.5 log more potent than the second and third ranked targets, IRAK4 (120 nM) and IRAK1 (390 nM), respectively. Takinib is an inhibitor of autophosphorylated TAK1 that non-competitively binds within the ATP binding pocket. Takinib induces apoptosis following TNF? stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Takinib is also a P. falciparum protein kinase 9 (PfPK9) inhibitor (KD(app) of 0.46 ?M)[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EDHS-206. CAS No. 1111556-37-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103490. | |
| Talabostat mesylate | Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor ( IC 50 < 4 nM; K i = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) ( IC 50 = 560 nM), inhibits DPP8/9 ( IC 50 = 4/11 nM; K i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) ( IC 50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Val-boroPro mesylate; PT100 mesylate. CAS No. 150080-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13233A. | |
| Talacotuzumab | Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123 -neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K D s of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ 56022473; CSL 362. CAS No. 1826831-79-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99395. | |
| Taladegib | Taladegib (LY2940680) is an antagonist of the smoothened receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2940680. CAS No. 1258861-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13242. | |
| Talampanel | Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity [1]. Talampanel (IVAX) has neuroprotective effects in rodent stroke models [2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GYKI-53773; LY-300164. CAS No. 161832-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15079. | |
| Talaporfin sodium | Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ME2906; Mono-L-aspartyl chlorin e6; NPe6. CAS No. 220201-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16477. | |
| Talarozole | Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC 50 s of 5.4 and 0.46 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R115866. CAS No. 201410-53-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14531. | |
| (-)-Talarozole | (-)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 201410-67-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14802D. | |
| (+)-Talarozole | (+)-Talarozole is a potent inhibitor of retinoic acid metabolism extracted from patent WO 1997049704 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 201410-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-14802C. | |
| Talatisamine | Talatisamine, a aconitum alkaloid, is specific K + channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons [1]. Uses: Scientific research. Group: Natural products. CAS No. 20501-56-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0663. | |
| Talazoparib | Talazoparib (BMN-673) is a highly potent, orally active PARP1/2 inhibitor.Talazoparib inhibits PARP1 and PARP2 enzyme activity with K i s of 1.2 nM and 0.87 nM, respectively. Talazoparib has antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN-673; LT-673. CAS No. 1207456-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16106. | |
| Talazoparib tosylate | Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC 50 of 0.57 nM for PARP1. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BMN 673ts. CAS No. 1373431-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-108413. | |
| Taldefgrobep alfa | Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a potent inhibitory antibody targeting to human myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BMS 986089; RG 6206; RO 7239361; BHV2000. CAS No. 1580555-26-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99518. | |
| Taletrectinib | Taletrectinib (DS-6051b) is a potent, orally active, and next-generation selective ROS1/NTRK inhibitor. Taletrectinib potently inhibits recombinant ROS1, NTRK1, NTRK2, and NTRK3 with IC 50 s of 0.207, 0.622, 2.28, and 0.98 nM, respectively. Taletrectinib also inhibits ROS1 G2032R and other Crizotinib-resistant ROS1 mutants [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DS-6051b; AB-106; IBI-344. CAS No. 1505515-69-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131003. | |
| Talfirastide | Angiotensin 1-7 (Ang-(1-7)) is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity ( IC 50 =0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: TXA127; Angiotensin (1-7); Ang-(1-7). CAS No. 51833-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12403. | |
| Talfirastide acetate | Angiotensin 1-7 (Ang-(1-7)) acetate is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 acetate inhibits purified canine ACE activity ( IC 50 =0.65 μM). Angiotensin 1-7 acetate acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 acetate blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: TXA127 acetate; Angiotensin (1-7) acetate; Ang-(1-7) acetate. CAS No. 2855063-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12403A. | |
| Talinolol | Talinolol (Cordanum) is a long-acting, cardioselective β1-adrenergic receptor blocker. Talinolol exhibits cardioprotective and antihypertensive activities. Talinolol is also a well-known and frequently used probe substrate for P-glycoprotein (P-gp) activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Cordanum. CAS No. 57460-41-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108286. | |
| Talizumab | Talizumab (TNX 901) is an anti-IgE humanized IgG1 monoclonal antibody [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: TNX 901; Anti-Human IgE Fc Recombinant Antibody. CAS No. 380610-22-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99319. | |
| Talmapimod | Talmapimod (SCIO-469) is an orally active, selective, and ATP-competitive p38α inhibitor with an IC 50 of 9 nM. Talmapimod shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SCIO-469. CAS No. 309913-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10406. | |
| Talniflumate | Talniflumate (BA 7602-06) is the proagent of Niflumic acid (HY-B0493), exerting its activity in the body through conversion to niflumic acid by esterase [1]. Talniflumate is an orally active Ca 2+ -activated Cl - channel (CaCC) blocker. Talniflumate can be used as an analgesic and anti-inflammatory agent in cystic fibrosis mouse model of distal intestinal obstructive syndrome [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BA 7602-06. CAS No. 66898-62-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103370. | |
| Talquetamab | Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ-64407564. CAS No. 2226212-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99394. | |
| Talsaclidine | Talsaclidine is a muscarinic agonist with preferential neuron-stimulating properties. Talsaclidine is a full agonist at the M1 subtype, and as a partial agonist at the M2 and M3 subtypes [1] [2] [3] [4]. Talsaclidine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 147025-53-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-128855. | |
| Taltirelin | Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910. CAS No. 103300-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596. | |
| Taltirelin acetate | Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist ( IC 50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC 50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TA-0910 acetate. CAS No. 1549593-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0596A. | |
| Tamarixetin | Tamarixetin (4'-O-Methyl Quercetin) is an orally active natural flavonoid derivative of quercetin and caseinolytic protease p ( ClpP ) inhibitor with anti-inflammatory, antioxidant and antitumor effects. Tamarixetin inhibits the hydrolytic activity of ClpP to the fluorescent substrate Suc-LY-AMC with an IC 50 of 49.73 μM, which can be used for the study of Staphylococcus aureus infection. Tamarixetin inhibits tumor cell growth, induces apoptosis , and cell cycle arrest. Tamarixetin prevents cardiac hypertrophy by inhibiting the NFAT and AKT pathways [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 4'-O-Methyl Quercetin. CAS No. 603-61-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N1181. | |
| Tambiciclib | Tambiciclib is a novel, highly selective CDK9 inhibitor critical for regulating transcription elongation. Tambiciclib demonstrated significant in vitro and in vivo efficacy against acute myeloid leukemia (AML)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GFH009; JSH-009. CAS No. 2247481-08-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-X0009. | |
| TAME | TAME is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 901-47-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255. | |
| TAME hydrochloride | TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC) , which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1784-03-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13255A. | |
| Tamibarotene | Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RAR&gamma. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Am 80. CAS No. 94497-51-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14652. | |
| Tamnorzatinib | Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC). Uses: Scientific research. Group: Signaling pathways. Alternative Names: ONO-7475. CAS No. 1646839-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114358. | |
| Tamoxifen | Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699; (Z)-Tamoxifen; trans-Tamoxifen. CAS No. 10540-29-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-13757A. | |
| Tamoxifen Citrate | Tamoxifen Citrate (ICI 46474) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3].Tamoxifen Citrate is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen Citrate also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen Citrate activates autophagy and induces apoptosis [4]. Tamoxifen Citrate also can induce gene knockout of CreER transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 46474; (Z)-Tamoxifen Citrate; trans-Tamoxifen Citrate. CAS No. 54965-24-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-13757. | |
| Tamoxifen (Standard) | Tamoxifen (Standard) is the analytical standard of Tamoxifen (HY-13757A). This product is intended for research and analytical applications. Tamoxifen (ICI 47699) is an orally active, selective estrogen receptor modulator ( SERM ) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells [1] [2] [3]. Tamoxifen is a potent Hsp90 activator and enhances the Hsp90 molecular chaperone ATPase activity. Tamoxifen also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC 50 of 0.1 μM and 1.8 μM, respectively [5]. Tamoxifen activates autophagy and induces apoptosis [4]. Tamoxifen also can induce gene knockout of CreER(T2) transgenic mouse [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ICI 47699(Standard); (Z)-Tamoxifen(Standard); trans-Tamoxifen (Standard). CAS No. 10540-29-1. Pack Sizes: 10 mg; 25 mg; 50 mg. Product ID: HY-13757AR. | |
| TAMRA azide, 5-isomer | TAMRA azide, 5-isomer is a click chemical containing azide groups that can be used as a linker for the orange dye TAMRA. The azide group of TAMRA Azide, 5-isomer enables copper-catalyzed click chemical reactions with alkynes, DBCO, and BCN [1] [2]. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 825651-66-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151857. | |
| TAMRA azide, 6-isomer | TAMRA azide, 6-isomer is an isomer of TAMRA, a xanthene dye with orange emission. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1192590-89-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D1306. | |
| TAMRA-Azide-PEG-biotin | TAMRA-Azide-PEG-biotin is a dye derivative of TAMRA (HY-135640). TAMRA-Azide-PEG-biotin contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1797415-74-7. Pack Sizes: 1 mg. Product ID: HY-140947. | |
| TAMRA-PEG3-Azide | TAMRA-PEG3-Azide is a dye derivative of TAMRA (HY-135640) containing 3 PEG units. TAMRA-PEG3-Azide contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Fluorescent dye. CAS No. 1228100-59-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-123629. | |
| Tamrintamab | Tamrintamab (SC-003 mAb, SC-Mab003, SC34.28ss1) is an ADC Antibody targeting to dipeptidase 3 ( DPEP3 or MBD3 ). DPEP3 is a glycosyl phosphatidylinositol anchored metallopeptidase that is overexpressed in ovarian tumors. Tamrintamab can specifically bind DPEP3-expressing cells to produce cytotoxicity. Tamrintamab can be used in ovarian cancer research [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: SC-003 mAb; SC-Mab003; SC34.28ss1. CAS No. 2148325-59-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99506. | |
| Tamsulosin | Tamsulosin ((R)-(-)-YM12617 free base) is an orally active antagonist of α 1 -adrenergic receptor. Tamsulosin induces Apoptosis. Tamsulosin is used for the research of prostatic hyperplasia. Tamsulosin attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-(-)-YM12617 free base; LY253351 free base. CAS No. 106133-20-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0661. | |
| Tamsulosin hydrochloride | Tamsulosin hydrochloride ((R)-(-)-YM12617 free base) is an orally active antagonist of α 1 -adrenergic receptor. Tamsulosin hydrochloride induces Apoptosis. Tamsulosin hydrochloride is used for the research of prostatic hyperplasia. Tamsulosin hydrochloride attenuates abdominal aortic aneurysm growth and inhibits inflammation in animal models [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. Alternative Names: (R)-(-)-YM12617; LY253351. CAS No. 106463-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0661A. | |
| Tanaproget | Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC50 of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSP-989. CAS No. 304853-42-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15606. | |
| Tandospirone | Tandospirone (SM-3997) is a potent and selective 5-HT 1A receptor partial agonist, with a K i of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-3997. CAS No. 87760-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14558. | |
| Tandospirone citrate | Tandospirone citrate is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SM-3997 citrate. CAS No. 112457-95-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0061. | |
| Tandutinib | Tandutinib (MLN518) is a potent and selective inhibitor of the FLT3 with an IC 50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC 50 s of 0.17 μM and 0.20 μM, respectively. Tandutinib can be used for acute myelogenous leukemia (AML) [1] [2]. Tandutinib has the ability to cross the blood-brain barrier [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN518; CT53518. CAS No. 387867-13-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10202. | |
| Tandutinib hydrochloride | Tandutinib hydrochloride (MLN518 hydrochloride) is a potent and selective inhibitor of the FLT3 with an IC 50 of 0.22 μM, and also inhibits c-Kit and PDGFR with IC 50 s of 0.17 μM and 0.20 μM, respectively. Tandutinib hydrochloride can be used for acute myelogenous leukemia (AML) [1] [2]. Tandutinib hydrochloride has the ability to cross the blood-brain barrier [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN518 hydrochloride; CT53518 hydrochloride. CAS No. 2438900-70-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10202A. | |
| Tanespimycin | Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC 50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 [1] [5]. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 17-AAG; NSC 330507; CP 127374. CAS No. 75747-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 100 mg; 200 mg. Product ID: HY-10211. | |
| Tanezumab | Tanezumab (RN-624) is a humanized anti- NGF mAb with high affinity and specificity. Tanezumab blocks NGF binding to its receptors, p75 and TrkA , in the peripheral nervous system. Tanezumab can be used in studies of acute and chronic pain such as osteoarthritis, knee and neuralgia, as well as post-herpetic neuralgia [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: RN-624; PF 4383119. CAS No. 880266-57-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99221. | |
| Tangeretin | Tangeretin (Tangeritin), a flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and is a Notch-1 inhibitor. Uses: Scientific research. Group: Natural products. Alternative Names: Tangeritin; NSC53909; NSC618905. CAS No. 481-53-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0133. | |
| Taniborbactam hydrochloride | Taniborbactam hydrochloride (VNRX-5133 hydrochloride) is a reversible and selective boronic acid-containing pan-spectrum β-lactamase inhibitor with IC 50 s of 8-530 nM. Taniborbactam hydrochloride has IC 50 s of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2. Taniborbactam hydrochloride is against Gram-negative bacteria [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VNRX-5133 hydrochloride. CAS No. 2244235-49-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-109124A. | |
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