MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Taurolithocholic acid | Taurolithocholic acid is a bile acid that has the activity of increasing cell viability, inducing the S phase of the cell cycle, and promoting DNA synthesis in a concentration-dependent manner in the intrahepatic cholangiocarcinoma cell line RMCCA-1. It can also increase the phosphorylation of EGFR and ERK 1/2 and the expression of cyclin D1 in RMCCA-1 cells, and its induced RMCCA-1 cell growth can be inhibited by specific antagonists and inhibitors. Uses: Scientific research. Group: Signaling pathways. CAS No. 516-90-5. Pack Sizes: 100 μg (206.74 μM * 1 mL in Methanol). Product ID: HY-113308. |  |
| Taurolithocholic acid 3-sulfate disodium | Taurolithocholic Acid 3-sulfate (disodium) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 3-Sulfotaurolithocholic acid disodium. CAS No. 64936-83-0. Pack Sizes: 1 mg. Product ID: HY-137255. | |
| Tauro-ω-muricholic acid sodium | Tauro-ω-muricholic acid sodium (TωMCA sodium) is a bile acid released by the liver and an analog of tauro-α-muricholic acid. Tauro-ω-muricholic acid sodium is investigated as a potential marker in plasma for early-onset neonatal sepsis (EOS) and cholestasis studies [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TωMCA sodium. CAS No. 2456348-84-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136066. | |
| Tauroursodeoxycholate | Tauroursodeoxycholate (Tauroursodeoxycholic acid) is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Uses: Scientific research. Group: Natural products. Alternative Names: Tauroursodeoxycholic acid; TUDCA; UR 906. CAS No. 14605-22-2. Pack Sizes: 10 mM * 1 mL; 50 mg. Product ID: HY-19696. | |
| Tauroursodeoxycholate sodium | Tauroursodeoxycholate (Tauroursodeoxycholic acid; TUDCA) sodium is an endoplasmic reticulum (ER) stress inhibitor. Tauroursodeoxycholate significantly reduces expression of apoptosis molecules, such as caspase-3 and caspase-12. Tauroursodeoxycholate also inhibits ERK. Uses: Scientific research. Group: Natural products. Alternative Names: Tauroursodeoxycholic acid sodium; TUDCA sodium; UR 906 sodium. CAS No. 35807-85-3. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-19696A. | |
| Tavaborole | Tavaborole (AN-2690) is an antifungal agent with activity against Trichophyton species, in a topical solution formulation for the potential treatment of onychomycosis. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AN-2690. CAS No. 174671-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10980. | |
| Tavapadon | Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06649751; CVL-751. CAS No. 1643489-24-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119486. | |
| Tavilermide | Tavilermide is a selective, partial agonist of TrkA , or a nerve growth factor (NGF) mimetic. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MIM-D3. CAS No. 263251-78-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17622. | |
| TAX2 peptide | TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-P10388. | |
| Taxifolin | Taxifolin ((+)-Dihydroquercetin) exhibits important anti- tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC 50 value of 193.3 μM [1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Dihydroquercetin; (+)-Taxifolin. CAS No. 480-18-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0136. | |
| (-)-Taxifolin | (-)-Taxifolin is the less active enantiomer of Taxifolin. Taxifolin exhibits important anti- tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC 50 value of 193.3 μM [1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Dihydroquercetin. CAS No. 111003-33-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N0136B. | |
| (±)-Taxifolin | (±)-Taxifolin ((±)-Dihydroquercetin) is the racemate of Taxifolin. Taxifolin exhibits important anti- tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC 50 value of 193.3 μM [1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-Dihydroquercetin. CAS No. 24198-97-8. Pack Sizes: 50 mg; 100 mg. Product ID: HY-N0136A. | |
| Tazarotene | Tazarotene (AGN 190168) is a selective retinoic acid receptor ( RAR ) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGN 190168. CAS No. 118292-40-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15388. | |
| Tazarotenic acid | Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGN 190299. CAS No. 118292-41-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101108. | |
| Tazemetostat | Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC 50 s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC 50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC 50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EPZ-6438; E-7438. CAS No. 1403254-99-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13803. | |
| Tazobactam | Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: CL-298741; YTR-830H. CAS No. 89786-04-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-B1418. | |
| Tazobactam sodium | Tazobactam sodium is an antibiotic of the beta-lactamase inhibitor class. Ceftolozane combines with Tazobactam, extends the activity of ceftolozane against many ESBL-producing Enterobacteriaceae and some Bacteroides spp. Uses: Scientific research. Group: Signaling pathways. CAS No. 89785-84-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W009168. | |
| TB5 | TB5 is a potent, selective and reversible inhibitor of hMAO-B with a K i value of 0.11±0.01 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 948841-07-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100975. | |
| TB500 | TB500 is a synthetic version of an active region of thymosin β 4. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation [1]. Uses: Scientific research. Group: Peptides. CAS No. 885340-08-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P0170. | |
| TBAJ-587 | TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 ?g/mL in MABA and LORA assay, respectively. TBAJ-587 inhibits hERG channel minimally, attenuates inhibition of the cardiac potassium channel protein coded by the hERG, which is important for cardiac repolarization[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2252316-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111747. | |
| TBAJ-876 | TBAJ-876 is the inhibitor of mycobacterium tuberculosis. TBAJ-876 is the analogue of the anti-tuberculosis agent Bedaquiline. TBAJ-876 has the potential for the research of tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2332841-25-3. Pack Sizes: 1 mg. Product ID: HY-128866. | |
| TBB | TBB is a cell-permeable and ATP-competitive CK2 inhibitor with an IC 50 of 0.15 μM for rat liver CK2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 231634; Casein Kinase II Inhibitor I. CAS No. 17374-26-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14394. | |
| TBCA | TBCA is a highly selective CK2 (casein kinase II) inhibitor with an IC 50 of 110 nM and a K i of 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934358-00-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110052. | |
| TBHQ | TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 [1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: tert-Butylhydroquinone. CAS No. 1948-33-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-100489. | |
| TBHQ (Standard) | TBHQ (Standard) is the analytical standard of TBHQ. This product is intended for research and analytical applications. TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2 [1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: tert-Butylhydroquinone (Standard). CAS No. 1948-33-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-100489R. | |
| TBI-223 | TBI-223 is an orally bioavailable oxazolidinone antibiotic and an antimicrobial. TBI-223 shows activity against Mycobacterium tuberculosis (Mtb) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2071265-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139398. | |
| tBID | tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 ( HIPK2 ) with an IC 50 of ?0.33 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1639895-85-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-100464. | |
| TBK1-IN-1 | TBK1-IN-1 is a potent and selective TANK binding kinase 1 (TBK1) inhibitor with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits TBK1 downstream target genes cxcl10 and ifn? expression. TBK1-IN-1 has anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-152237. | |
| TBOPP | TBOPP is a selective inhibitor of DOCK1 with an IC50 of 8.4 ?M. TBOPP binds to the DOCK1 DHR-2 domain with high affinity (Kd of 7.1 ?M), has anti-tumor activity for broader types of tumors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1996629-79-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-124711. | |
| TBPB | TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats. Uses: Scientific research. Group: Signaling pathways. CAS No. 634616-95-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-14562. | |
| TbPTR1 inhibitor 2 | TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC 50 s of 34.2 and 32.9 μM for Tb PTR1 and Lm PTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei ( IC 50 : 34.2 μM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17557-67-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W009689. | |
| TC11 | TC11 is a MCL1 degrader and Caspase-9 and CDK1 activator. TC11 functions as a phenylacetylamide derivative and is structurally related to immunomodulatory active molecules. TC11 induces degradation of MCL1 leading to apoptotic death [1] [2] during prolonged mitotic arrest. Uses: Scientific research. Group: Signaling pathways. CAS No. 100823-03-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129478. | |
| TC13172 | TC13172 is a mixed lineage kinase domain-like protein (MLKL) inhibitor with an EC50 value of 2 nM for HT-29 cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2093393-05-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101524. | |
| TCB2 | TCB2 is an agonist of serotonin 5-HT 2A receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 912342-28-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103102. | |
| TC-DAPK 6 | TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 ?M ATP). Uses: Scientific research. Group: Signaling pathways. CAS No. 315694-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15513. | |
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 ( PRMT1 ) inhibitor with an IC 50 of 1.5 μM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17328-16-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-107574. | |
| TCEP hydrochloride | TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tris(2-carboxyethyl)?phosphine hydrochloride. CAS No. 51805-45-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-W011500. | |
| TC-G-1008 | TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GPR39-C3. CAS No. 1621175-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103007. | |
| TCH-165 | TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1446350-60-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-120722. | |
| TC-I 15 | TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin ?2?1 inhibitor, and it also inhibits ?1?1 and ?11?1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 916734-43-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107588. | |
| TCID | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC 50 of 0.6 μM [1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,5,6,7-Tetrachloroindan-1,3-dione. CAS No. 30675-13-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18638. | |
| TCL053 | TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 2361162-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147332. | |
| TC LPA5 4 | TC LPA5 4 is a LPA 5 (GPR92) -specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA 5 -RH7777 cell line) with an IC 50 of 800 nM. TC LPA5 4 displays selectivity for LPA 5 over 80 other screened agent targets [1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1393814-38-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107615. | |
| TCMCB07 | TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Mifomelatide. CAS No. 1456699-27-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5971. | |
| TCMDC-135051 | TCMDC-135051 is a highly selective and potent protein kinase Pf CLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC 50 =320 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413716-15-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126323. | |
| TCMDC-135051 hydrochloride | TCMDC-135051 hydrochloride is a highly selective and potent protein kinase Pf CLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC 50 =320 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2705545-47-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-126323B. | |
| TCMTB | TCMTB is one of the so-called emerging contaminants (EC). TCMTB is also an antifouling agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21564-17-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101425. | |
| TC-N 1752 | TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 ?M, 0.3 ?M, 0.4 ?M, 1.1 ?M and 2.2 ?M at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1211866-85-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107405. | |
| TCO-NHS ester | TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs [1]. TCO-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1191901-33-3. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-141165. | |
| TCO-PEG3-Biotin | TCO-PEG3-Biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. TCO-PEG3-Biotin is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg. Product ID: HY-136050. | |
| TCO-PEG3-maleimide | TCO-PEG3-maleimide (TCO-PEG3-NEM) is a click chemistry reagent. TCO-PEG3-maleimide efficiently binds TCO (trans-cyclooctene) moiety to thiol-containing molecules (such as antibodies, cysteine-containing peptides) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1809356-72-6. Pack Sizes: 5 mg. Product ID: HY-151696. | |
| TCO-PEG4-NHS ester | TCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. TCO-PEG4-NHS ester is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1621096-79-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-141167A. | |
| TCO-PEG4-VC-PAB-MMAE | TCO-PEG4-VC-PAB-MMAE is a agent-linker conjugate for ADC. TCO-PEG4-VC-PAB-MMAE contains a cleavable ADC linker (TCO-PEG4-VC-PA) and a potent tubulin inhibitor MMAE (HY-15162)[1]. TCO-PEG4-VC-PAB-MMAE is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2758671-45-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-148057. | |
| TCS 1102 | TCS 1102 is a potent, dual orexin receptor antagonist, with Ki values of 0.2 nM and 3 nM for OX2 and OX1 receptors, respectively. TCS 1102 demonstrates excellent blood-brain barrier penetrability and moderate bioavailability in rats[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 916141-36-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10900. | |
| TCS 21311 | TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKC?, PKC?, and GSK3? with IC50s of 13, 68, and 3 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NIBR3049. CAS No. 1260181-14-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108264. | |
| TCS-OX2-29 | TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX 2 R) antagonist with an IC 50 value of 40 nM and a pK I value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX 2 over OX 1 [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 372523-75-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100452. | |
| TCTDSTNCYKAT | TCTDSTNCYKAT is an engineered-variant peptide of antifreeze protein (AFP) [1]. Uses: Scientific research. Group: Peptides. CAS No. 1621188-94-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3158. | |
| tcY-NH2 TFA | tcY-NH2 ((trans-Cinnamoyl)-YPGKF-NH2) TFA is a potent selective PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH 2 -induced platelet aggregation and endostatin release, and can be used in the research of inflammation, immunology [1] [2] [6]. Uses: Scientific research. Group: Peptides. Alternative Names: (trans-Cinnamoyl)-YPGKF-NH2 TFA. CAS No. 1262750-73-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1263A. | |
| TD-165 | TD-165 is a PROTAC-based cereblon ( CRBN ) degrader. TD-165 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2305936-56-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130714. | |
| TD52 | TD52, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 has less p-EGFR inhibition and has potent anti-cancer activity [1]. TD52 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1798328-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135699. | |
| TDCPP | TDCPP is a chlorinated analog of tris(2,3-dibromopropyl)phosphate (Tris) which is one of the most detected organophosphorus flame retardants (OPFRs) in the environment. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tris(1,3-dichloroisopropyl)phosphate. CAS No. 13674-87-8. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-108712. | |
| TDI-011536 | TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2687970-96-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150042. | |
| TDI-10229 | TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2810887-45-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132298. | |
| TDI-11055 | TDI-11055 is an inhibitor of the epigenetic reader protein 11-19 leukemia (ENL) YEATS, which drives the oncogenic transcriptional program of acute myeloid leukemia (AML), the hematopoietic malignancy AML[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162350. | |
| TDI-11861 | TDI-11861 is an orally active soluble sAC inhibitor optimized and designed based on TDI-10229 (HY-132298), with an IC50 of 3.3 nM and a KD of 1.4 nM. TDI-11861 has advantages such as high affinity, slow dissociation, and good pharmacokinetics. TDI-11861 can be used for research on male contraception and related sAC pharmacology[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2857049-72-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-151798. | |
| TDRL-551 | TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1644626-43-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114842. | |
| TDZD-8 | TDZD-8 is an inhibitor of GSK-3β , with an IC 50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin?B, CK-II, PKA, and PKC, with all IC 50 s of >100 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-3β Inhibitor I; NP 01139. CAS No. 327036-89-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11012. | |
| Tea polyphenol | Tea polyphenol is the floorboard of phenolic compounds in tea. Tea polyphenol exhibits biological activity including antioxidant and anti-cancer activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism [1]. Uses: Scientific research. Group: Natural products. CAS No. 84650-60-2. Pack Sizes: 1 g. Product ID: HY-N1925. | |
| Tebapivat | Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-946; PKR activator 2. CAS No. 2283422-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-135884. | |
| Tebentafusp | Tebentafusp (IMCgp100) is a bispecific fusion protein to target gp100 peptide-HLA-A*02:01 (a melanoma-associated antigen). Tebentafusp guides T cells to kill gp100 -expressing tumor cells via a high affinity T-cell receptor (TCR) binding domain and an anti-CD3 T-cell engaging domain. Tebentafusp leads to inflammatory cytokines and cytolytic proteins production, resulting in the direct lysis of tumour cells [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMCgp100. CAS No. 1874157-95-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99339. | |
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