MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tetrahydrobiopterin | Tetrahydrobiopterin ((Rac)-Sapropterin) is a cofactor of the aromatic amino acid hydroxylases enzymes and also acts as an essential cofactor for all nitric oxide synthase (NOS) isoforms. Uses: Scientific research. Group: Natural products. Alternative Names: (Rac)-Sapropterin. CAS No. 17528-72-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107383. |  |
| Tetrahydrocortisol | Tetrahydrocortisol is cortisol metabolite. The urinary Tetrahydrocortisol / Tetrahydrocortisone ratio decreases with increasing 11β-hydroxysteroid dehydrogenase (11β-HSD) activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 53-02-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-129630. | |
| Tetrahydrocortisone | Tetrahydrocortisone is a stress-induced hormone. Tetrahydrocortisone is also a urinary metabolite of Cortisone derived from the reduction of Cortisone by 5-reductase [1]. Uses: Scientific research. Group: Natural products. CAS No. 53-05-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-113114. | |
| Tetrahydrocurcumin | Tetrahydrocurcumin is a Curcuminoid found in turmeric ( Curcuma longa ) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. Uses: Scientific research. Group: Natural products. Alternative Names: HZIV 81-2. CAS No. 36062-04-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0893. | |
| Tetrahydrocurcumin (Standard) | Tetrahydrocurcumin (Standard) is the analytical standard of Tetrahydrocurcumin. This product is intended for research and analytical applications. Tetrahydrocurcumin is a Curcuminoid found in turmeric (Curcuma longa) that is produced by the reduction of Curcumin. Tetrahydrocurcumin inhibit CYP2C9 and CYP3A4. Uses: Scientific research. Group: Natural products. CAS No. 36062-04-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0893R. | |
| Tetrahydrodeoxycorticosterone | Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABA A receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Tetrahydro-11-deoxycorticosterone. CAS No. 567-03-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113346. | |
| Tetrahydrofolic acid | Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid [1]. Uses: Scientific research. Group: Natural products. Alternative Names: L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid. CAS No. 135-16-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14520. | |
| Tetrahydroharmine | Tetrahydroharmine (Leptaflorine) is A monoamine oxidase ( MAO ) inhibitor with a IC 50 value of 74 nM for MAO-A. Tetrahydroharmine can be used in the study of neurodegenerative diseases [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Leptaflorine. CAS No. 17019-01-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-125515. | |
| Tetrahydromagnolol | Tetrahydromagnolol (Magnolignan), the main metabolite of Magnolol, is a potent and selective cannabinoid CB2 receptor agonist ( EC 50 =170 nM) and GPR55 antagonist. The K i of Tetrahydromagnolol for CB2 is 416 nM, 20-fold higher than for the CB1 receptor. Magnolol shows antifungal, anti-inflammatory and analgesic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Magnolignan. CAS No. 20601-85-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116637. | |
| Tetrahydropalmatine | Tetrahydropalmatine possesses analgesic effects. Tetrahydropalmatine acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats [1]. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Tetrahydropalmatine. CAS No. 2934-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0300. | |
| Tetrahydropalmatine hydrochloride | Tetrahydropalmatine (DL-Tetrahydropalmatine) hydrochloride possesses analgesic effects. Tetrahydropalmatine hydrochloride acts through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats [1]. Uses: Scientific research. Group: Natural products. Alternative Names: DL-Tetrahydropalmatine hydrochloride. CAS No. 6024-85-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0300A. | |
| Tetrahydrothiopyran-4-one | Tetrahydrothiopyran-4-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1072-72-6. Pack Sizes: 10 mM * 1 mL; 25 g; 100 g. Product ID: HY-W002007. | |
| Tetrahydrouridine | Tetrahydrouridine dihydrate is potent inhibitor of cytidine deaminase ( CDA ), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: THU; NSC-112907. CAS No. 18771-50-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-15345A. | |
| Tetrahydroxydiboron | Tetrahydroxydiboron can be used to optimize the Miyaura borylation process, replacing bis(pinacolato) diboron by hydrolyzing the resulting boronic ester to its corresponding acid [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Hypodiboric acid. CAS No. 13675-18-8. Pack Sizes: 10 mM * 1 mL; 25 g. Product ID: HY-W004761. | |
| Tetrahydroxymethoxychalcone | Tetrahydroxymethoxychalcone is a phenolic and flavonoid compound. Tetrahydroxymethoxychalcone is found to enhance myoblast proliferation and differentiation. Tetrahydroxymethoxychalcone plays important roles in myogenesis and muscle regeneration [1]. Uses: Scientific research. Group: Natural products. CAS No. 197227-39-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N9334. | |
| Tetrahydrozoline | Tetrahydrozoline (Tetryzoline), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline is widely used for the research of nasal congestion and conjunctival congestion [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tetryzoline. CAS No. 84-22-0. Pack Sizes: 25 mg. Product ID: HY-B0556. | |
| Tetrahydrozoline hydrochloride | Tetrahydrozoline hydrochloride (Tetryzoline hydrochloride), a derivative of imidazoline, is an α-adrenergic agonist that causes vasoconstriction. Tetrahydrozoline hydrochloride is widely used for the research of nasal congestion and conjunctival congestion [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tetryzoline hydrochloride. CAS No. 522-48-5. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0556A. | |
| Tetrakis(acetonitrile)palladium(II) tetrafluoroborate | Tetrakis(acetonitrile)palladium(II) tetrafluoroborate (NSC 307191) acts as a potent Lewis acid and facilitates the formation of the 2:1 complex [Pd(1,2-bis(2-pyridylethynyl)benzene)2](BF4)2 through the Sonogashira cross-coupling reaction. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 307191; Palladium(II) tetrafluoroborate tetraacetonitrile complex. CAS No. 21797-13-7. Pack Sizes: 100 mg. Product ID: HY-W033277. | |
| Tetrakis (triphenylphosphine) palladium | Tetrakis (triphenylphosphine) palladium is a catalyst. Tetrakis (triphenylphosphine) palladium catalyzes the highly regioselective addition of phenyl thiocyanate (PhSCN) to terminal alkynes [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Tetrakis (triphenylphosphine)palladium (0). CAS No. 14221-01-3. Pack Sizes: 5 g; 10 g. Product ID: HY-Y1738. | |
| Tetramethrin | Tetramethrin is a synthetic pyrethroid insecticide for use on a broad spectrum of insect pests [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 7696-12-0. Pack Sizes: 25 mg. Product ID: HY-W040149. | |
| Tetramethylammonium-d12 chloride | Tetramethylammonium-d12 (chloride) is the deuterium labeled Tetramethylammonium chloride[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 23789-03-9. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W012954S. | |
| Tetramethylammonium tetrafluoroborate | Tetramethylammonium Tetrafluoroborate is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 661-36-9. Pack Sizes: 5 g; 25 g. Product ID: HY-W127672. | |
| Tetramethylkaempferol | Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicans Candida albicans with an IC 50 value of 17.63 μg/mL [1]. Uses: Scientific research. Group: Natural products. CAS No. 16692-52-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-137794. | |
| Tetramisole hydrochloride | Tetramisole hydrochloride inhibits alkaline phosphatase and is a highly pure antiparasitic agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (±)-Tetramisole hydrochloride; DL-Tetramisole hydrochloride; R-829. CAS No. 5086-74-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 2 g. Product ID: HY-B1194. | |
| Tetrandrine | Tetrandrine (NSC-77037; d-Tetrandrine) is a bis-benzyl-isoquinoline alkaloid, which inhibits voltage-gated Ca 2+ current (ICa) and Ca 2+ -activated K + current. Uses: Scientific research. Group: Natural products. Alternative Names: NSC-77037; d-Tetrandrine. CAS No. 518-34-3. Pack Sizes: 100 mg; 250 mg. Product ID: HY-13764. | |
| Tetraoctylammonium bromide | Tetraoctylammonium bromide (TOAB) is a quaternary ammonium salt consisting of a positively charged tetraoctylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic chemical reactions, facilitating the transfer of reactants between immiscible phases. It is also used as a surfactant and dispersant in various industrial applications, for example in the production of coatings, adhesives and polymers. Additionally, Tetraoctylammonium bromide has been investigated for potential applications in energy storage devices and as an antimicrobial agent. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 14866-33-2. Pack Sizes: 500 g. Product ID: HY-W018574. | |
| Tetraoctylammonium iodide | Tetraoctylammonium iodideIt is an organic compound and belongs to the category of quaternary ammonium salts. It is often used as a phase transfer catalyst, meaning it facilitates a reaction between two immiscible phases, such as an aqueous phase and an organic phase. Tetraoctylammonium iodideIt has a variety of applications in organic synthesis, especially in reactions involving nucleophilic substitution, oxidation, and reduction. Additionally, it is used as a surfactant and emulsifier in industrial and laboratory settings. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Tetra-n-octylammonium iodide. CAS No. 16829-91-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-W099640. | |
| Tetrapentylammonium bromide | Tetrapentylammonium bromide is a quaternary ammonium salt consisting of a positively charged tetrapentylammonium cation and a negatively charged bromide anion. This compound is commonly used as a phase transfer catalyst in organic synthesis reactions to facilitate the transfer of reactants between immiscible phases. It is also used in the production of surfactants, detergents and the synthesis of pharmaceuticals. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 866-97-7. Pack Sizes: 5 g; 10 g. Product ID: HY-W011052. | |
| Tetrapeptide-21 | Tetrapeptide-21 is a bioactive peptide with anti-wrinkle and and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient [1]. Uses: Scientific research. Group: Peptides. CAS No. 960608-17-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5232. | |
| Tetraphenylporphyrin | Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin. CAS No. 917-23-7. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-103656. | |
| Tetrapropylammonium perruthenate | Tetrapropylammonium perruthenate (TPAP) is an organic compound commonly used as a catalyst and oxidizing agent. It can play an oxidation role in some organic synthesis reactions, and can catalyze the oxidation reactions of olefins and aromatic compounds. In addition, the compound is widely used in some industrial production areas, such as in the application of plastics, rubber and textile manufacturing processes. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: TPAP. CAS No. 114615-82-6. Pack Sizes: 250 mg; 500 mg; 1 g. Product ID: HY-W007801. | |
| Tetrasodium pyrophosphate | Tetrasodium pyrophosphate is a kind of biological materials or organic compounds that are widely used in life science research [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 7722-88-5. Pack Sizes: 5 g. Product ID: HY-Y1885. | |
| Tetraxetan | Tetraxetan (DOTA) is a macrocyclic chelating agent. Tetraxetan can form stable coordination complexes with a variety of metal ions (e.g., 68Ga, 111In, 177Lu). Tetraxetan can be conjugated with targeting molecules (e.g., RGD peptide, folic acid) to enable the complex to target specific biomolecules or cells. Tetraxetan can be used for imaging studies of tumors, including melanoma and folate receptor-positive tumors (e.g., cervical cancer) [1][2][3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: DOTA. CAS No. 60239-18-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg; 1 g. Product ID: HY-W053583. | |
| Tetrazine-Amine monohydrochloride | Tetrazine-Amine monohydrochloride is the monohydrochloride form of Tetrazine-Amine (HY-W053709). Tetrazine-amine is a Tetrazine linker that can be used to covalently label living cells by cycloaddition[1][2]. Tetrazine-Amine (monohydrochloride) is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (4-(1,2,4,5-Tetrazin-3-yl)phenyl)methanamine monohydrochloride; Tetrazine-NH2 monohydrochloride. CAS No. 1416711-59-5. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W053709A. | |
| Tetrazine-Ph-acid | Tetrazine-Ph-acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tetrazine-Ph-acid is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1380500-92-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-124480. | |
| Tetrazine-Ph-PEG5-NHS ester | Tetrazine-Ph-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Tetrazine-Ph-PEG5-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1682653-80-0. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-130551. | |
| Tetrazolium Red | Tetrazolium Red (2,3,5-Triphenyltetrazolium chloride; TTC) is a not brain-penetrant, colorless, water-soluble dye that is reduced by mitochondrial enzymes to a deep red, water-insoluble compound (formazan) mainly in the mitochondria of living cells. Tetrazolium Red is used to observe the activity of dehydrogenase, and it turns colorless to red when exposed to hydrogen. Tetrazolium Red distinguishes between surviving and infarcted brain tissue after stroke. Tetrazolium Red has been used to stain heart tissue to measure the extent of acute lesions and also used to stain brain tissue to detect the size of the infarcted area. The absorption wavelength of Tetrazolium Red is 570 nm[1][2][3][4]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 2,3,5-Triphenyltetrazolium chloride; TPTZ; TTC. CAS No. 298-96-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-D0714. | |
| Tetroxoprim | Tetroxoprim is an antimicrobial DHFR inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HE 781. CAS No. 53808-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107033. | |
| Texasin | Texasin is a natural product that can be isolated from Baptisia australis [1]. Uses: Scientific research. Group: Natural products. CAS No. 897-46-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119822. | |
| Texas Red | Texas Red (Sulforhodamine 101) is an amphoteric rhodamine red fluorescent dye (excitation/emission: 586/605 nm). Texas Red is used extensively for investigating neuronal morphology and acts as acell type-selective fluorescent marker of astrocytes bothin vivoand in slice preparations [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Sulforhodamine 101; SR101. CAS No. 60311-02-6. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-101878. | |
| Tezacaftor | Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-661. CAS No. 1152311-62-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15448. | |
| Tezacitabine | Tezacitabine is a cytostatic and cytotoxic antimetabolite and a nucleoside analogue. Tezacitabine irreversibly inhibits the ribonucleotide reductase and interferes with DNA replication and repair. Tezacitabine effectively induces cells apoptotic. Tezacitabine has the potential for leukemias and solid tumors (carcinomas) treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130306-02-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106014. | |
| Tezepelumab (anti-TSLP) | Tezepelumab (anti-TSLP) is human monoclonal antibody (IgG2λ) that binds specifically to TSLP , blocking it from interacting with its heterodimeric receptor. Tezepelumab can be used for the research of severe, uncontrolled asthma [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG 157 (anti-TSLP); MEDI 19929 (anti-TSLP); Tezepelumab-ekko (anti-TSLP). CAS No. 1572943-04-4. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99366A. | |
| Tezosentan | Tezosentan (RO 610612) is an endothelin (ET) receptor antagonist, with pA 2 s of 9.5, 7.7 for ET A and ET B receptors, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RO 610612. CAS No. 180384-57-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17351. | |
| TFAP | TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC 50 of 0.8 μM. Uses: Scientific research. Group: Natural products. Alternative Names: N-(5-Aminopyridin-2-yl)-4-(trifluoromethyl)benzamide. CAS No. 1011244-68-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112731. | |
| TFEB activator 1 | TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 39777-61-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135825. | |
| TFM-4AS-1 | TFM-4AS-1 is a selective androgen receptor modulator (SARM) , and a potent androgen receptor (AR) ligand with an IC 50 of 38 nM. TFM-4AS-1 is a gene-selective agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 188589-61-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-103246. | |
| TFMB-(R)-2-HG | TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML). TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445700-01-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079. | |
| TFMB-(S)-2-HG | TFMB-(S)-2-HG is a potent TET2 inhibitor. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG downregulates Wnt3a, ?-catenin (intranuclear) protein expression. TFMB-(S)-2-HG inhibits osteogenic differentiation of cells. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1445703-64-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-129079A. | |
| TG003 | TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 719277-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15338. | |
| TG 100801 | TG 100801 is a proagent that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases ; has IC 50 s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1 , VEGFR2 , FGFR1 , FGFR2 , PDGFRβ , Fgr , Fyn , Hck , Lck , Lyn , Src , Yes , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 867331-82-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10186. | |
| TG101209 | TG101209 is a selective JAK2 inhibitor with IC 50 of 6 nM, less potent to Flt3 and RET with IC 50 of 25 nM and 17 nM, appr 30-fold selective for JAK2 than JAK3, and sensitive to JAK2V617F and MPLW515L/K mutations. Uses: Scientific research. Group: Signaling pathways. CAS No. 936091-14-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10410. | |
| TG4-155 | TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K i of 9.9 nM [1] [2]. TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 [1]. TG4-155 has an EP2 Schild K B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1164462-05-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-18971. | |
| TGFβ-IN-2 | TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC 50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387678-02-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-146434. | |
| TGFβ-IN-5 | TGFβ-IN-5(Compd 12) is a TGFβ inhibitor useful for the study of fibroproliferative diseases associated with TGF-β signaling [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 259870-32-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128437. | |
| TGFBR1-IN-2 | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 733806-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164793. | |
| TGN-020 | TGN-020 is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3].TGN-020 alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 51987-99-6. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-W008574. | |
| TGN-020 sodium | TGN-020 sodium is a selective Aquaporin 4 (AQP4) inhibitor with an IC50 of 3.1 ?M[1][2]. TGN-020 sodium is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[3]. TGN-020 sodium alleviates edema and inhibits glial scar formation after spinal cord compression injury in rats[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313731-99-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-W008574A. | |
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. | |
| TGX-221 | TGX-221 is a potent, selective, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, used for cancer treatment. Uses: Scientific research. Group: Signaling pathways. CAS No. 663619-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10114. | |
| TH1020 | TH1020 is a potent and selective toll-like receptor 5 (TLR5)/flagellin complex antagonist with an IC50 of 0.85 ?M. TH1020 inhbits flagellin-induced TLR5 signaling. TH1020 is inactive against TLR2, TLR3, TLR4, TLR7 and TLR8[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1841460-82-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116961. | |
| TH10785 | TH10785 is a DNA glycosylase 1 (OGG1) activator, TH10785 can interact with the phenylalanine-319 and glycine-42 amino acids of OGG1 and increase the enzyme activity, generates ?, ?-lyase enzymatic function. TH10785 can control the catalytic activity mediated by a nitrogen base within its molecular structure. TH10785 can be used for the research of various diseases and aging connected with DNA oxidative lesions[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1002801-51-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147313. | |
| TH1217 | TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ZINC1775962367. CAS No. 1862212-48-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135909. | |
| TH1834 | TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2108830-08-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-123604. | |
| TH5427 | TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2253744-56-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-125209. | |
| TH5487 | TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304947-71-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-125276. | |
| TH588 | TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1609960-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12814. | |
| TH-6 | TH-6 is a potent HDAC inhibitor with IC 50 s of 0.115, 0.135, 0.242, 0.138, 2.120 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively. TH-6 inhibits cell migration and invasion. TH-6 induces apoptosis and cell cycle arrest at G2/M phase. TH-6 shows anti-tumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031349-25-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149029. | |
| TH9619 | TH9619 is a potent inhibitor of dehydrogenase and cyclohydrolase activities in both MTHFD1 and MTHFD2 with a IC50 value of 47 nM, and selectively kills cancer cells. TH9619 induces apoptosis by blocking the S phase. TH9619 has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2379556-22-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-155950. | |
| Thailanstatin A | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker-less ADC[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1426953-21-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-129589. | |
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