MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| Tizanidine | Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 51322-75-9. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194. |  |
| Tizanidine-d4 | Tizanidine-d 4 is the deuterium labeled Tizanidine. Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1188331-19-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0194S. | |
| Tizanidine hydrochloride | Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons. Uses: Scientific research. Group: Signaling pathways. CAS No. 64461-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0194A. | |
| Tizoxanide | Tizoxanide (TIZ) is the active metabolite of Nitazoxanide, which is a thiazolide anti-infective compound against anaerobic bacteria, protozoa, and a range of viruses. Tizoxanide (TIZ) has anti-HIV-1 activities and potent inhibition of both HBV and HCV replication with values EC 50 of 0.46μM and 0.15 μM, respectively. Tizoxanide also exerts anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and suppressing of the activation of the NF-κB and the MAPK signaling pathways in LPS-treated macrophage cells [1] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TIZ. CAS No. 173903-47-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12687. | |
| TJ-M2010-5 | TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway[1][2]. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI)[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1357471-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139397. | |
| TK05 | TK05 is a potent and selective inhibitor of leukotriene C 4 synthase (LTC4S) with an IC 50 of 95 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1245734-61-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117143. | |
| TK-129 | TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM). TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3031476-73-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151483. | |
| TK216 | TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1903783-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903. | |
| (-)-TK216 | (-)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor. (-)-TK216 has anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1903783-78-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903A. | |
| (+)-TK216 | (+)-TK216 is an enantiomer of TK216 (HY-122903). TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1903783-77-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122903B. | |
| TKIM | TKIM is a TREK-1 channel inhibitor with an IC 50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326921-25-9. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-134559. | |
| TL02-59 | TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC 50 of 0.03 nM. TL02-59 inhibits Lyn and Hck with IC 50 s of 0.1 nM and 160 nM, respectively. TL02-59 potently suppresses acute myelogenous leukemia (AML) cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1315330-17-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112852. | |
| TL8-506 | TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1268163-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-20457. | |
| TL-895 | TL-895 is a potent, orally active, ATP-competitive, and highly selective irreversible BTK inhibitor with an IC 50 and a K i of 1.5 nM and 11.9 nM, respectively [1]. TL-895 is used be for JAKi-relapsed/refractory myelofibrosis, acute myeloid leukemia, COVID-19 and cancer research [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415823-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139481. | |
| TLCK-treated Chymotrypsin | TLCK-treated Chymotrypsin is a serine protease. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids. TLCK treated to inactivate residual tryspin activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 9004-7-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108910B. | |
| TLR1 | TLR1 (compound 4a) is a low molecular weight, cell-penetrating Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop mimic. TLR1 inhibits IL-1 receptor-mediated responses [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 566914-00-9. Pack Sizes: 500 μg (33 mM * 50 μL in Ethanol); 1 mg (33 mM * 100 μL in Ethanol). Product ID: HY-W011400. | |
| TLR4-IN-C34 | TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40592-88-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107575. | |
| TLR7/8/9-IN-1 | TLR7/8/9-IN-1 is a potent and orally bioavailable small molecule antagonist (IC50 = 43 nM) of Toll-like receptors 7/8/9 (TLR7/8/9). Uses: Scientific research. Group: Signaling pathways. CAS No. 2180127-82-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131952. | |
| TLR7/8 agonist 1 | TLR7/8 agonist 1 is a toll-like receptor ( TLR7 )/ TLR8 dual-agonistic imidazoquinoline. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258457-59-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698. | |
| TLR7/8 agonist 1 dihydrochloride | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620278-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103698A. | |
| TLR7/8 agonist 4 | TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist. TLR7/8 agonist 4 has anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2388520-33-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139017. | |
| TLR7/8 agonist 8 | TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC 50 s of 27 and 12 nM for hTLR7 and hTLR8 , respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2649170-16-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-153543. | |
| TLR7 agonist 1 | TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC 50 of 90 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2178156-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111358. | |
| TLR9-IN-1 | TLR9-IN-1 is a potent and selective TLR9 inhibitor with an IC50 value of 7 nM for human TLR9. TLR9-IN-1 can be used for researching diseases associated with undesirable immune response[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226366-86-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148045. | |
| TM-1 | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase ( PDHK1 ). TM-1 inhibits PDHK1 and PDHK2 with IC 50 s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 921099-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136882. | |
| TM5275 sodium | TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 1103926-82-4. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100447. | |
| TM5441 | TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 ?M and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates N?-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190221-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101761. | |
| TMA-DPH | TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 115534-33-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-D0986. | |
| TMB | TMB is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB can function as a photoacoustic probe for reactive oxygen and nitrogen species ( ROS/RNS ), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue; Sure Blue TMB. CAS No. 54827-17-7. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930. | |
| TMB dihydrochloride | TMB dihydrochloride is the dihydrochloride form of TMB (HY-15930). TMB dihydrochloride is a non-toxic, non-mutagenic, colorless dye that is also used as a chromogenic agent in enzyme detection systems based on horseradish peroxidase (HRP). TMB dihydrochloride can function as a photoacoustic probe for reactive oxygen and nitrogen species (ROS/RNS), reacting with hypochlorite, hydrogen peroxide, singlet oxygen, and nitrogen dioxide to produce blue oxidation products. TMB dihydrochloride can detect the singlet oxygen produced by the outer membrane of Escherichia coli ATCC 25922 [1] [2]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: BM blue dihydrochloride; Sure Blue TMB dihydrochloride. CAS No. 64285-73-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15930A. | |
| TMC310911 | TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC 50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASC-09. CAS No. 1000287-05-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107123. | |
| TMI-1 | TMI-1 (WAY-171318) inhibits TNF converting enzyme (TACE) ( IC 50 of 8.4 nM), ADAM-TS-4 , ADAM-17 and various MMPs with oral activity. TMI-1 significantly suppresses the secretion of TNF-α , alleviating collagen-induced arthritis in mice. TMI-1 inhibits cancer cell proliferation, induces apoptosis through a caspase-dependent pathway. TMI-1 also reverses TRPV1 upregulation and lowers the levels of inflammatory factors ( TNF-α , IL-1β , IL-6 ) in nerve cells, protecting against paclitaxel-induced neurotoxicity. TMI-1 leads to changes in pro-atherogenic lipoprotein profiles, but does not affect the progression of early lesions [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: WAY-171318. CAS No. 287403-39-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-101448. | |
| TM-N1324 | TM-N1324 is an agonist of G-Protein-Coupled Receptor 39 (GPR39) with EC50s of 9 nM/5 nM in the presence of Zn2+, and 280 nM/180 nM in the absence of Zn2+ for human/murine GPR39. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144477-35-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108699. | |
| TMP195 | TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with Kis of 59, 60, 26, 15 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314891-22-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-18361. | |
| TMP269 | TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC50s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1314890-29-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-18360. | |
| TMPA | TMPA is a high-affinity Nur77 antagonist that binds to Nur77 leading to the release and shuttling of LKB1 in the cytoplasm to activate AMPK&alpha. TMPA effectively lowers blood glucose and attenuates insulin resistance in type II db/db, high-fat diet and streptozotocin-induced diabetic mice. TMPA reduces RICD (restimulation-induced cell death) in human T cells, can also be used in studies of cancer and T-cell apoptosis dysregulation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1258275-73-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18555. | |
| TMPD dihydrochloride | TMPD dihydrochloride, a readily oxidizable compound, is an enzymatically convert redox active substrate molecule. TMPD dihydrochloride is also an electron donor and serves as a reducing cosubstrate for heme peroxidases [1] [2]. TMPD dihydrochloride is also a complex IV substrate [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-01-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W012145. | |
| TMPyP4 tosylate | TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand. TMPyP4 tosylate inhibits the interaction between G-quadruplexes and IGF-1. TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. TMPyP4 tosylate is also a stabilizer of nucleic acid secondary structure and an acetylcholinesterase inhibitor. Besides, TMPyP4 tosylate has antiviral activity against SARS-CoV-2[1][2][3][6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMP 1363. CAS No. 36951-72-1. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108477. | |
| TMRE | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms[1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Tetramethylrhodamine ethyl ester perchlorate. CAS No. 115532-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-D0985A. | |
| TMRM Perchlorate | Rhodamine dyes are membrane-permeable cationic fluorescent probes that specifically recognize mitochondrial membrane potentials, thereby attaching to mitochondria and producing bright fluorescence, and at certain concentrations, rhodamine dyes have low toxicity to cells, so they are commonly used to detect mitochondria in animal cells, plant cells, and microorganisms [1]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: T668. CAS No. 115532-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-D0984A. | |
| TMS | TMS ((E)-2,3',4,5'-tetramethoxystilbene) is a selective and competitive CYP1B1 inhibitor with an IC 50 of 6 nM and a K i value of 3 nM. TMS shows a lesser extent inhibitory effect on CYP1A1 (IC 50 =300 nM) and CYP1A2 (IC 50 =3.1 μM). TMS is a methylated derivative of resveratrol and has anti-cancer activity [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (E)-2,3',4,5'-tetramethoxystilbene. CAS No. 24144-92-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19340. | |
| TN1 | TN1 is a potent fetal hemoglobin ( HbF ) inducer. Uses: Scientific research. Group: Signaling pathways. CAS No. 289479-94-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-100826. | |
| Tn5 Transposase | Tn5 Transposase is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 308064-67-7. Pack Sizes: 25 U. Product ID: HY-E70347. | |
| TNF-α-IN-1 | TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7. Uses: Scientific research. Group: Signaling pathways. CAS No. 444287-49-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-112275. | |
| TNF-α-IN-18 | TNF-α-IN-18 (Compound 61) is an inhibitor for TNF-α ( IC 50 of 1.8 μM), that inhibits TNF signaling pathway through block of NF-kB migration from cytoplasm to nucleus. TNF-α-IN-18 exhibits slight cytotoxicity to mouse fibroblast LM cell, with a CC 50 >50 μM. TNF-α-IN-18 ameliorates the TNF- or Lipopolysaccharide (HY-D1056)-induced sepsis in mouse models. TNF-α-IN-18 protects mice from rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1272322-42-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164102. | |
| TNF-α-IN-8 | TNF-α-IN-8 (compound I-42) is a TNF-α inhibitor. TNF-α-IN-8 is an isoindole-imide compound. TNF-α-IN-8 can be used for the research of cancer, heart disease, osteoporosis, inflammatory, allergic and autoimmune diseases [1]. TNF-α-IN-8 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 444287-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148908. | |
| TNG260 | TNG260 is a CoREST-selective deacetylase ( CoreDAC ) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2935964-98-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153358. | |
| TNG348 | TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2839740-79-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160700. | |
| TNKS-2-IN-2 | TNKS-2-IN-2 is a potent and selective inhibitor of TNKS2 with an IC 50 of 22 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2719726-91-5. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-156332. | |
| TNP | TNP is a cell-permeable inhibitor of IP6K1 and IP3K , with IC 50 values of 0.55 μM and 10.2 μM for IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 519178-28-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110079. | |
| TNP-470 | TNP-470 is a methionine aminopeptidase-2 inhibitor and also an angiogenesis inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGM-1470. CAS No. 129298-91-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-101932. | |
| TNS sodium | TNS (sodium) (6-(p-Tolylamino)naphthalene-2-sulfonate (sodium)) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 6-(p-Tolylamino)naphthalene-2-sulfonate sodium. CAS No. 53313-85-2. Pack Sizes: 100 mg; 250 mg. Product ID: HY-W250727. | |
| Tobevibart | Tobevibart is an IgG1-lambda, anti- HBV (hepatitis B virus) surface envelope protein human monoclonal antibody. Tobevibart shows antiviral activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2645440-65-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P990015. | |
| Tobramycin | Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms [1].Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Nebramycin Factor 6; Deoxykanamycin B. CAS No. 32986-56-4. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-B0441. | |
| Tobramycin sulfate | Tobramycin sulfate (Nebramycin Factor 6 sulfate) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Nebramycin Factor 6 sulfate; Deoxykanamycin B sulfate. CAS No. 49842-07-1. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B0441A. | |
| Tocainide | Tocainide hydrochloride is an orally active sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 41708-72-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1798. | |
| Tocainide hydrochloride | Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71395-14-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B1798A. | |
| Toceranib | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR , VEGFR , and Kit with K i s of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU11654; PHA 291639E. CAS No. 356068-94-5. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-10330. | |
| Toceranib phosphate | Toceranib phosphate (SU11654 phosphate) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibits PDGFR , VEGFR , and Kit with K i s of 5 and 6 nM for PDGFRβ and Flk-1/KDR, respectively. Toceranib phosphate (SU11654 phosphate) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU11654 phosphate; PHA 291639E phosphate. CAS No. 874819-74-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10330A. | |
| Tocilizumab | Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor ( IL-6R ) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis [1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL6R, Humanized Antibody. CAS No. 375823-41-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9917. | |
| Tocofersolan | Tocofersolan is synthetic polyethylene glycol derivative of ?-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TPGS; D-?-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS. CAS No. 9002-96-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g; 25 g. Product ID: HY-B0717. | |
| Tocopherols | Tocopherols are an important class of fat-soluble vitamins, the most common form of which is gamma-tocopherol, followed by beta-tocopherol and alpha-tocopherol [1]. Uses: Scientific research. Group: Natural products. CAS No. 1406-66-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-126400. | |
| Todralazine hydrochloride | Todralazine hydrochloride (Ecarazine hydrochloride) is an anti-hypertensive agent, acts as a β 2 AR blocker, with antioxidant and free radical scavenging activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ecarazine hydrochloride. CAS No. 3778-76-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B1001A. | |
| TOFA | TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α ( ACCA ). Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMI14514; MDL14514. CAS No. 54857-86-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101068. | |
| Tofacitinib | Tofacitinib is an orally available JAK3/2/1 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib; CP-690550. CAS No. 477600-75-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354. | |
| Tofacitinib citrate | Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC 50 s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tasocitinib citrate; CP-690550 citrate. CAS No. 540737-29-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-40354A. | |
| Tofersen | Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIIB067; ISIS-SOD1Rx. CAS No. 2088232-70-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132580. | |
| Tofersen sodium | Tofersen sodium is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen sodium can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIIB067 sodium; ISIS-SOD1Rx sodium. CAS No. 1898254-60-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-132580A. | |
| Tofisopam | Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent. Tofisopam can inhibit phosphodiesterase PDE isoenzyme activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 22345-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0165. | |
| Tofogliflozin hydrate | Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC 50 of 2.9 nM and K i values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2 [1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CSG-452 hydrate. CAS No. 1201913-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13413. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.