MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| (Z)-JQ1-TCO | JQ1-TCO (JQ1- trans -cyclooctene) is a derivative of JQ1 (HY-13030), an inhibitor of BET. JQ1-TCO is suitable for click chemistry and can be used as molecular probes in vitro and in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2087490-43-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-148864A. |  |
| ZK 93423 | ZK 93423 is a potent benzodiazepine GABAA receptor agonist with a certain cooling effect on rodents [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 83910-44-5. Pack Sizes: 1 mg. Product ID: HY-116813. | |
| ZL006 | ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor -mediated NO synthesis. Uses: Scientific research. Group: Signaling pathways. CAS No. 1181226-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100456. | |
| ZL-2201 | ZL-2201 is a potent DNA-PK inhibitor with an IC 50 of 1 nM (WO2021104277A1, compound 5) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2865115-39-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142471A. | |
| ZLD115 | ZLD115 (compound 44) is a FB23-derivated inhibitor of Fat Mass and Obesity-associated Protein (FTO). ZLD115 is an antileukemic agent, exhibiting antiproliferative activity against leukemic cell lines[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2980653-93-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149334. | |
| Z-LEHD-FMK | Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma[1][2][3]. Uses: Scientific research. Group: Peptides. CAS No. 210345-04-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P1010. | |
| Z-Leu-Arg-AMC | Z-Leu-Arg-AMC is a 4-methylcoumarinyl-7-amide (Amc) leucine derivative with carboxybenzoyl (Z). Z-Leu-Arg-AMC is the active site of cysteine proteinase trypanopain-Tb from Trypanosoma brucei brucei [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 156192-32-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-142021. | |
| Z-Leu-Leu-Glu-AMC | Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-LLE-AMC. CAS No. 348086-66-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-123053. | |
| Z-LEVD-FMK | Z-LEVD-FMK is a cell-permeable caspase-4 inhibitor. Z-LEVD-FMK blocks ER stress-induced apoptosis in cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1135688-25-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128707. | |
| (Z)-Ligustilide | (Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort, has antimicrobial and antifungal activity, exhibits an average antifungal score of 5.6 [1]. (Z)-Ligustilide is orally active, it inhibits the expression of FATP5 and DGAT, inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2]. (Z)-Ligustilide is also able to reactivate ERα, has epigenetic regulation, and is used in the study of tamoxifen-resistant breast cancer [3]. Uses: Scientific research. Group: Natural products. CAS No. 81944-09-4. Pack Sizes: 5 mg; 10 mg; 20 mg. Product ID: HY-N0401A. | |
| (Z-LL)2 ketone | (Z-LL)2 ketone is an inhibitor of ketone with an IC 50 value of 50 nM. (Z-LL)2 ketone promotes the release of an N-terminal fragment into the cytosol [1]. Uses: Scientific research. Group: Peptides. CAS No. 313664-40-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P1425. | |
| ZLN005 | ZLN005 is a potent activator of peroxisome proliferator-activated receptor-? coactivator-1? (PGC-1?)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 49671-76-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17538. | |
| ZLN024 hydrochloride | ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC 50 s of 0.42 μM, 0.95 μM, 1.1 μM and 0.13 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883548-91-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16708A. | |
| Z-L-Val-OH | Z-L-Val-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Cbz-L-valine. CAS No. 1149-26-4. Pack Sizes: 25 g. Product ID: HY-W008753. | |
| Z-Lys-OH | Z-Lys-OH is a lysine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 2212-75-1. Pack Sizes: 10 g; 25 g; 100 g; 500 g. Product ID: HY-W009337. | |
| ZM241385 | ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 139180-30-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-19532. | |
| ZM323881 hydrochloride | ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC 50 of less than 2 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 193000-39-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15467A. | |
| ZM 336372 | ZM 336372 is a potent inhibitor of the protein kinase c-Raf. The IC 50 value is 0.07 μM in the standard assay, which contains 0.1 mM ATP. Uses: Scientific research. Group: Signaling pathways. CAS No. 208260-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13343. | |
| ZM-447439 | ZM-447439 is an aurora kinase inhibitor with IC 50 s of 110 and 130 nM for aurora A and B, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 331771-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10128. | |
| ZM 449829 | ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3 , with a pIC 50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4452-6-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13450. | |
| Zn(II) Mesoporphyrin IX | Zn(II) Mesoporphyrin IX (ZnMP) is a specific activator of ABCB10 , significantly increasing its ATPase activity and acting as a substrate for ABCB10 in heme synthesis. Zn(II) Mesoporphyrin IX may promote the transcription of hemoglobinization genes by facilitating the degradation of the Bach1 repressor. Zn(II) Mesoporphyrin IX aids in studying the potential roles of ABCB10 in heme synthesis, oxidative stress protection, hepatitis C, and other areas [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: ZnMP. CAS No. 14354-67-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-W583212. | |
| Zofenopril | Zofenopril is an angiotensin-converting enzyme ( ACE ) inhibitor with an IC 50 of 81 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 81872-10-8. Pack Sizes: 5 mg. Product ID: HY-108321. | |
| Zofenopril calcium | Zofenopril Calcium (SQ26991) is an orally active angiotensin-converting enzyme ( ACE ) inhibitor with antioxidant activity and cardioprotective effects. Zofenopril Calcium reduces ROS production and GSH consumption and helps inhibit foam cell formation, thus slowing the progression of atherosclerosis. Zofenopril Calcium prevents cardiac damage caused by chronic Doxorubicin (HY-15142A). Uses: Scientific research. Group: Signaling pathways. Alternative Names: SQ26991. CAS No. 81938-43-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0655. | |
| Zolbetuximab | Zolbetuximab (IMAB362) is a monoclonal antibody targeting Claudin-18.2. Zolbetuximab mediates specific killing of Claudin-18.2-positive cells through immune effector mechanisms. Zolbetuximab can be used for the research of gastrointestinal adenocarcinomas and pancreatic tumors [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: IMAB362. CAS No. 1496553-00-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99058. | |
| Zoldonrasib | RMC-9805 (KRAS G12D inhibitor 18) is a potent and orally active KRAS G12D inhibitor. RMC-9805 induces apoptosis in KRAS G12D mutant cancer cells. RMC-9805 has the potential for the research of KRAS G12D mutant cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMC-9805; KRAS G12D inhibitor 18. CAS No. 2922732-54-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156819. | |
| Zoledronic Acid | Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zoledronate; CGP 42446; CGP42446A; ZOL 446. CAS No. 118072-93-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-13777. | |
| Zoledronic acid monohydrate | Zoledronic acid monohydrate (Zoledronate monohydrate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic acid monohydrate inhibits the differentiation and apoptosis of osteoclasts. Zoledronic acid monohydrate also has anti-cancer effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate. CAS No. 165800-06-6. Pack Sizes: 50 mg; 100 mg. Product ID: HY-13777A. | |
| Zoliflodacin | Zoliflodacin (ETX0914;AZD0914) is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC 90 of 0.25 μg/mL. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ETX0914; AZD0914. CAS No. 1620458-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17647. | |
| Zolimidine | Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222-57-7. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-108278. | |
| Zolmitriptan | Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with K i s of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: BW-311C90; 311C90. CAS No. 139264-17-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0229. | |
| Zomiradomide | KT-413 (example I-3) is an orally active PROTAC-class IRAK degrader [1]. KT-413 consists of a target protein ligand (red part) PROTAC IRAK4 ligand-5 (HY-168311), an E3 ubiquitin ligase ligand (blue part) Thalidomide-4-Br (HY-W039116), and a PROTAC linker (black part) 2-(2-Azaspiro[3.3]heptan-6-yl)ethanamine (HY-168313). E3 ubiquitin ligase and linker can form Thalidomide-NH-C2-2-azaspiro[3.3]heptane (HY-168312). The active control for the target protein ligand is RSL3-4-Me (HY-169375). Uses: Scientific research. Group: Signaling pathways. Alternative Names: KT-413. CAS No. 2655656-99-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153368. | |
| Zongertinib | Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC 50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BI 1810631. CAS No. 2728667-27-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-148810. | |
| Zoniporide | Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22 Na + uptake by human NHE-1 -expressing fibroblasts in a concentration-dependent manner ( IC 50 =14 nM). Zoniporide inhibits platelet swelling in vitro with an IC 50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-597396. CAS No. 241800-98-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-105064. | |
| Zoniporide hydrochloride hydrate | Zoniporide (CP-597396) hydrochloride hydrate is a potent and selective inhibitor of sodium-hydrogen exchanger type 1 (NHE-1). Zoniporide hydrochloride hydrate inhibits human NHE-1 ( IC 50=14 nM), and has >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride hydrate potently inhibits ex vivo NHE-1-dependent swelling of human platelets (IC 50 =59 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-597396 hydrochloride hydrate. CAS No. 863406-85-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-105064D. | |
| Zonisamide | Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor, with K i s of 35.2 and 20.6 nM for hCA II and hCA V , respectively. Zonisamide exerts neuroprotective effects through anti- apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1 , thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure, parkinsons disease and cardiac hypertrophy [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AD 810; CI 912. CAS No. 68291-97-4. Pack Sizes: 10 mM * 1 mL; 200 mg; 500 mg. Product ID: HY-B0124. | |
| Zorevunersen sodium | Zorevunersen sodium is an antisense oligonucleotide that is intended to increase the level of productive SCN1A mRNA and consequently increase the expression of the sodium channel Nav1.1 protein. Zorevunersen sodium is used for the study of Dravet syndrome. Uses: Scientific research. Group: Signaling pathways. Alternative Names: STK-001 sodium. CAS No. 2415330-05-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148410A. | |
| Zorifertinib | Zorifertinib (AZD3759) is a potent, orally active, central nervous system-penetrant, EGFR inhibitor. At K m ATP concentrations, the IC 50 s are 0.3, 0.2, and 0.2 nM for EGFR wt , EGFR L858R , and EGFR exon 19Del , respectively. Zorifertinib induces cancer cell apoptosis. Zorifertinib has antitumor activity, and can be used for NSCLC, HCC etc. research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD3759. CAS No. 1626387-80-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18750. | |
| Zosuquidar | Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor ( K i =59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RS 33295-198; LY-335979. CAS No. 167354-41-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-15255. | |
| Zosuquidar trihydrochloride | Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RS 33295-198 trihydrochloride; LY-335979 trihydrochloride. CAS No. 167465-36-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50671. | |
| Zosurabalpin | Zosurabalpin is a polypeptide antibiotic targeting LPS transporter (LptB 2 FGC complex), which can block the transport of LPS and lead to endotoxin accumulation in cells, and has shown excellent antibacterial activity against Carbapenem-resistant Acinetobacter baumanni (CRAB) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Abx MCP; RG6006. CAS No. 2379336-76-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147429. | |
| Zotarolimus | Zotarolimus (ABT-578) is a derivative of Rapamycin (HY-10219), with anti-proliferative activity. Zotarolimus is an immunosuppressant. Zotarolimus is developed specifically for local delivery from stents for the prevention of coronary artery restenosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABT-578; A 179578. CAS No. 221877-54-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-12424. | |
| Zotatifin | Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5-UTRs ( IC 50 =2 nM) and interferes with the assembly of the eIF4F initiation complex [1]. Zotatifin shows robust antiviral effects, it effectively reduces viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis ( IC 90 =37 nM) [2]. Zotatifin induces cell apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: eFT226. CAS No. 2098191-53-6. Pack Sizes: 1 mg; 2 mg; 5 mg; 10 mg. Product ID: HY-112163. | |
| Zotepine | Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT 2A , 5-HT 2C , Histamine H 1 , α 1 -adrenergic and Dopamine D 2 receptors , with K d s of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM and 8 nM, respectively. Zotepine exhibits antidepressive and anxiolytic effects in vivo [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 26615-21-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-103093. | |
| Zotizalkib | Zotizalkib (TPX-0131) is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK ( IC 50 of 1.4 nM) and ALK-resistant mutation , e.g. G1202R ( IC 50 of 0.3 nM), L1196M ( IC 50 of 0.3 nM). Zotizalkib has strong antitumor activities [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TPX-0131. CAS No. 2648641-36-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-139279. | |
| Zoxazolamine | Zoxazolamine is widely used for a pharmacologic test that serves as a convenient indicator of changes in cytochrome P-450 activity in rodents. Uses: Scientific research. Group: Signaling pathways. CAS No. 61-80-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B1307. | |
| Z-Phe-Leu-Glu-pNA | Z-Phe-Leu-Glu-pNA is a chromogenic substrate for glutamyl endopeptidases. Z-Phe-Leu-Glu-pNA has been used as a synthetic substrate in the study of proteolytic enzymes, including trypsin treatment, subtilisin and chymotrypsin. Z-Phe-Leu-Glu-pNA plays an important role in hormone disorders such as prostate cancer and breast cancer [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 104634-10-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P4516. | |
| (Z)-PUGNAc | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 132489-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-108241. | |
| Z-Pyr-OH | Z-Pyr-OH (Cbz-L-pyroglutamic acid) can be used as a biochemical assay reagent [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Cbz-L-pyroglutamic acid. CAS No. 32159-21-0. Pack Sizes: 25 g; 50 g; 100 g. Product ID: HY-W011750. | |
| ZQ-16 | ZQ-16 is a potent and selective GPR84 agonist with an EC50 value of 0.213 ?M. ZQ-16 has no activity on the other free fatty acid receptors (FFARs), including GPR40, GPR41, GPR119 and GPR120[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 376616-73-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124571. | |
| ZSTK474 | ZSTK474 is an ATP-competitive pan-class I PI3K inhibitor with IC 50 s of 16 nM, 44 nM, 4.6 nM and 49 nM for P&Lota;3Κα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 475110-96-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-50847. | |
| ZT-1a | ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 ?M at ATP concentrations of 0.01, 0.1 and 1 mM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 212135-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-136532. | |
| ZT55 | ZT55 is an orally active and highly-selective JAK2 inhibitor with an IC 50 value of 0.031 μM. ZT55 inhibits the proliferation of JAK2 V617F -expressing HEL cell lines and induces apoptosis and cycle arrest. ZT-55 also effectively inhibits the growth of HEL xenograft tumours in a mice model. ZT-55 can be used in studies of myeloproliferative neoplasms, polycythemia vera and primary thrombocythemia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2138488-38-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-124727. | |
| (Z)-Thiothixene | (Z)-Thiothixene is an antagonist of serotonergic receptor extracted from patent US 20150141345 A1. Uses: Scientific research. Group: Signaling pathways. CAS No. 3313-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108324. | |
| Z-Tyr-OH | Z-Tyr-OH is a tyrosine derivative [1]. Uses: Scientific research. Group: Peptides. CAS No. 1164-16-5. Pack Sizes: 25 g; 100 g. Product ID: HY-W007931. | |
| Zuclomiphene citrate | Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 7619-53-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1617A. | |
| Zuclopenthixol | Zuclopenthixol ((Z)-Clopenthixol) is a thioxanthene derivative which acts as a mixed dopamine D1/D2 receptor antagonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (Z)-Clopenthixol. CAS No. 53772-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-A0163. | |
| Zunsemetinib | Zunsemetinib (CDD-450) is an orally active and selective p38? mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. Zunsemetinib can be used for the research of immuno-inflammatory diseases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATI-450; CDD-450. CAS No. 1640282-42-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-139553. | |
| Z-VAD | Z-VAD is a competitive, irreversible pan- caspase inhibitor. Z-VAD inhibits all 10 caspases, except for caspase-2 which is only weakly inhibited. Z-VAD decreases radiation-induced apoptosis. Z-VAD induces both autophagy and necrosis in irradiated MDA-MB-231 and H460 mouse xenografts. Z-VAD with radiation produces a significant tumor growth delay and shows dramatic antiangiogenic effect in cancer xenograft [1]. Uses: Scientific research. Group: Peptides. CAS No. 162852-62-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164388. | |
| Z-VAD-FMK | Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 ?M[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z-VAD(OH)-FMK. CAS No. 161401-82-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16658B. | |
| Z-VAD(OMe)-FMK | Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor[1]. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Z-Val-Ala-Asp(OMe)-FMK. CAS No. 187389-52-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-16658. | |
| Z-Val-Val-Arg-AMC | Z-Val-Val-Arg-AMC is a fluorescent peptide substrate that can be used to test the activity of cathepsins [1]. Uses: Scientific research. Group: Peptides. CAS No. 124485-41-2. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-137367. | |
| Z-VDVAD-FMK | Z-VDVAD-FMK is a special inhibitor of caspase-2. Z-VDVAD-FMK produces a reduction in Lovastatin-induced apoptosis[1][2][3]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-VD(OMe)VAD(OMe)-FMK. CAS No. 210344-92-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-P1008. | |
| Z-VEID-FMK | Z-VEID-FMK (Z-VE(OMe)ID(OMe)-FMK) is a selective and irreversible caspase-6 peptide inhibitor. Z-VEID-FMK alleviates the drug-induced augmentation of caspase-6 activity, DNA fragmentation, and cell apoptosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Z-VE(OMe)ID(OMe)-FMK. CAS No. 210344-96-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1007. | |
| ZW4864 | ZW4864 is an orally active and selective ? catenin/B-Cell lymphoma 9 protein protein interaction (? catenin/BCL9 PPI) inhibitor. ZW4864 inhibits ? catenin/BCL9 PPI with a Ki value of 0.76 ?M and an IC50 value of 0.87 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2632259-93-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132300. | |
| ZXH-3-26 | ZXH-3-26 is a PROTAC connected by ligands for Cereblon and BRD4 with a DC50/5h of 5 nM. The DC50/5h refers to half-maximal degradation after 5 hours of treatment of ~ 5 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2243076-67-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122826. | |
| ZY-444 | ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase. Uses: Scientific research. Group: Signaling pathways. CAS No. 1802650-31-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142870. | |
| Zymosan A | Zymosan A (Zymosan A from Saccharomyces cerevisiae) is a TLR2 agonist, that targeting TLRs can prevent and suppress IR-induced intestinal injury. Zymosan A exhibits a significant radioprotective effect, and protects IR-induced intestinal injury in mice. Zymosan A promotes the regeneration of intestinal stem cells (ISCs), after IR injury [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Zymosan A from Saccharomyces cerevisiae. CAS No. 58856-93-2. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W250113. | |
| Zymostenol | Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol. Zymostenol is a RORγ agonist ( EC 50 : 1 μM) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5a-Cholest-8-en-3b-ol. CAS No. 566-97-2. Pack Sizes: 1 mg. Product ID: HY-113345. | |
| Zymostenol-d7 | Zymostenol-d 7 is deuterium labeled 5a-Cholest-8-en-3b-ol. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 5a-Cholest-8-en-3b-ol-d7. CAS No. 2260669-19-8. Pack Sizes: 1 mg. Product ID: HY-113345S. | |
| Zymosterol | Zymosterol is a Cholesterol (HY-N0322) biosynthesis metabolite. Zymosterol, a precursor of Cholesterol, is found mostly in the plasma membrane. Zymosterol circulates within the cell [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 128-33-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-114297. | |
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