MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| XMD8-92 | XMD8-92 is a potent ERK5 (BMK1)/BRD4 inhibitor with K d s of 80 and 190 nM, respectively. XMD8-92 inhibits DCAMKL2, PLK4 and TNK1 with K d s of 190, 600 and 890 nM, respectively. Anti-cancer activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1234480-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14443. |  |
| XMT-1519 conjugate-1 | XMT-1519 conjugate-1 (compound 31) is part of the drug-linker conjugate for ADC and can be conjugated with the HER-2 monoclonal antibody Calotatug (XMT-1519) (HY-P990909) for the synthesis of ADC[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2720500-19-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-148067. | |
| XMU-MP-1 | XMU-MP-1 is a reversible and selective MST1/2 inhibitor with IC50s of 71.1 and 38.1 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2061980-01-4. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100526. | |
| XMU-MP-2 | XMU-MP-2 is a BRK inhibitor with significant inhibitory activity on BRK-positive cells. XMU-MP-2 inhibits oncogenic BRK-driven tumor growth in a mouse xenograft model. XMU-MP-2 also synergizes with HER2 inhibitors or endoplasmic reticulum (ER) blockade to exert antiproliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2031152-10-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-122664. | |
| XMU-MP-9 | XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used for the study of colon, lung and pancreatic cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2251130-41-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-162809. | |
| XO44 | XO44 (PF-6808472) is a broad-spectrum covalent kinase probe. XO44 can bind in CDK 2 and CDK 1. XO44 also labels CDK4 proteins in cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-6808472. CAS No. 2088112-70-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122609. | |
| XP-59 | XP-59 is a potent inhibitor of the SARS-CoV M pro , with a K i of 0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890402-73-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-136284. | |
| XPhos | XPhos (2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl) is a biochemical reagent that can be used as a biological material or organic compound for life science related research [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 2-(Dicyclohexylphosphino)-2',4',6'-triisopropylbiphenyl. CAS No. 564483-18-7. Pack Sizes: 10 g; 25 g. Product ID: HY-Y0006. | |
| XR5944 | XR5944 is an anti-tumor compound with DNA-targeting activity. As a topoisomerase inhibitor, XR5944 can effectively inhibit the activities of topoisomerase I and II. XR5944 shows excellent anti-tumor activity against human and mouse tumor cells in vitro and in vivo. XR5944 exhibits significant potency in multiple cell lines, with IC 50 values of 0.04-0.4 nM. XR5944 is not affected by atypical drug resistance in cells and remains significantly active even in cells overexpressing P-glycoprotein or multidrug resistance-related proteins. XR5944 showed anti-tumor efficacy in human tumor models of H69 small cell lung cancer and HT29 colon cancer, inducing tumor regression in most animals in the HT29 model. XR5944 can be used to study biological processes related to colon and lung cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 343247-32-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-118899. | |
| XRK3F2 | XRK3F2 is an inhibitor of p62 (Sequestosome-1)-ZZ/ domain. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375193-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112904. | |
| XRP44X | XRP44X inhibits Ras-induced transcription activation with the IC50 of 10 nM. XRP44X inhibits activation of the Ras-Erk-1/2 pathway by FGF-2[1]. XRP44X is an inhibitor of Ras/Erk activation of Elk3 that also affects microtubules[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 729605-21-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107753. | |
| XST-14 | XST-14 is a potent, competitive and highly selective ULK1 inhibitor with an IC50 of 26.6 nM. XST-14 induces autophagy inhibition by reducing the phosphorylation of the ULK1 downstream substrate. XST-14 induces apoptosis in hepatocellular carcinoma (HCC) cells and has antitumor effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2607143-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137506. | |
| xStAx-VHLL | xStAx-VHLL is a ?-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of ?-catenin. xStAx-VHLL inhibits the Wnt/?-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5819. | |
| xStAx-VHLL TFA | xStAx-VHLL TFA is a ?-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of ?-catenin. xStAx-VHLL TFA inhibits the Wnt/?-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity[1]. Uses: Scientific research. Group: Peptides. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P5819A. | |
| XT2 | XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase ( NIK ) with an IC 50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases [1]. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 2582816-37-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145801. | |
| XTT sodium | XTT (sodium) is used to assess cell viability as a function of redox potential. Actively respiring cells convert the water-soluble XTT to a water-soluble, orange colored formazan product. Uses: Scientific research. Group: Signaling pathways. CAS No. 111072-31-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122131. | |
| XY018 | XY018 is a potent ROR-?-selective antagonist. XY018 inhibits ROR-? constitutive activity in 293T cells with high potency (EC50, 190 nM). XY018 binds to the ROR-? hydrophobic ligand binding domain (LBD)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1873358-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-120210. | |
| XY028-140 | XY028-140 is a PROTAC connected by ligands for Cereblon and CDK. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2229974-83-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-138946. | |
| XY101 | XY101 is a potent, selective, metabolically stable and orally available RORγ inverse agonist with an IC 50 of 30 nM and a K d of 380 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2349368-16-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128604. | |
| Xylan | Xylan represents the main hemicellulose component in the secondary plant cell walls of flowering plants. Xylan is a polysaccharide made from units of xylose and contains predominantly β-D-xylose units linked as in cellulose [1]. Uses: Scientific research. Group: Natural products. CAS No. 9014-63-5. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-107846. | |
| Xylene Cyanol FF | Xylene Cyanol FF is an acid triphenylmethane dye. Xylene Cyanol FF can be used for histochemical staining of hemoglobin peroxidase or as a tracking dye for DNA sequencing in electrophoresis. Xylene Cyanol FF will be catalyzed by Fe and Al to accelerate oxidation under the addition of double oxidant hydrogen peroxide and potassium periodate. Xylene Cyanol FF thus enables the spectrophotometric determination of Fe and Al in the solution to be tested [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 2650-17-1. Pack Sizes: 1 g; 5 g; 10 g. Product ID: HY-D0945. | |
| Xylitol | Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy ( Autophagy ) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: Xylite. CAS No. 87-99-0. Pack Sizes: 10 mM * 1 mL; 1 g. Product ID: HY-N0538. | |
| Xylobiose | Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is a disaccharide of xylose monomers with a β-1, 4 bond between monomers [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 1,4-β-D-Xylobiose; 1,4-D-Xylobiose. CAS No. 6860-47-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N2468. | |
| Xylohexaose | Xylohexaose is a xylooligosaccharide consisting of six xylose residues. Xylohexaose can be used as substrate in the xylan hydrolysis properties assay[1][2]. Uses: Scientific research. Group: Natural products. CAS No. 49694-21-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N6831. | |
| Xylometazoline hydrochloride | Xylometazoline hydrochloride is an α-adrenergic receptor agonist ( K i =0.05-1.7 μM). Xylometazoline hydrochloride can constrict nasal blood vessels and increase nasal airflow. Xylometazoline hydrochloride can be used in nose stuffiness and runny nose research [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1218-35-5. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B0475. | |
| Xylose | Xylose (D-(+)-Xylose) is a natural pentose sugar that is catalyzed by xylose isomerase to form xylulose, which is a key step in the anaerobic ethanol fermentation of Xylose. Xylose can be used by microorganisms to produce fuels, chemicals, and bulk industrial enzymes. Xylose provides the substances and energy for cells, as a carbon source for the biosynthesis of high-value chemicals and biofuel. Xylose can be used to fully explore lignocellulose resources and provide a new direction for microbia fermentation [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: D-(+)-Xylose; (+)-Xylose; Wood sugar. CAS No. 58-86-6. Pack Sizes: 10 mM * 1 mL; 50 g; 100 g. Product ID: HY-N0537. | |
| Xylotriose | Xylotriose is a natural xylooligosaccharide, acts as a bifidogenic factor [1]. Uses: Scientific research. Group: Natural products. CAS No. 47592-59-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N2469. | |
| Y11 | Y11 inhibits FAK1 autophosphorylation by blocking phosphorylation of Y397 and decreases tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1086639-59-9. Pack Sizes: 1 mg. Product ID: HY-103471. | |
| Y15 | Y15 is a potent and specific inhibitor of focal adhesion kinase (FAK) that inhibits its autophosphorylation activity, decreases the viability of cancer cells, and blocks tumor growth. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FAK Inhibitor 14. CAS No. 4506-66-5. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12444. | |
| Y16 | Y16 is a specific inhibitor of Leukemia-associated Rho guanine nucleotide exchange factor (LARG) with a K d value of 76 nM. Y16 is active in blocking the interaction of LARG and related G-protein-coupled Rho GEFs with RhoA. Y16 shows no detectable effect on other diffuse B-cell lymphoma (Dbl) family Rho GEFs, Rho effectors, or a RhoGAP [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 429653-73-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-12649. | |
| Y1 receptor antagonist 1 | Y1 receptor antagonist 1 (H 409-22 isomer) is a neuropeptide Y1 receptor antagonist. Uses: Scientific research. Group: Signaling pathways. Alternative Names: H 409-22 (isomer). CAS No. 221697-09-2. Pack Sizes: 1 mg. Product ID: HY-101704. | |
| Y-27632 | Y-27632 is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II , with K i s of 220 and 300 nM, respectively. Y-27632 attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 146986-50-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10071. | |
| Y-27632 dihydrochloride | Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK ( Rho-kinase ) inhibitor (ROCK-I K i =220 nM; ROCK-II K i =300 nM). Y-27632 dihydrochloride shows antiepileptic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10583. | |
| Y-27632 dihydrochloride (GMP) | Y-27632 dihydrochloride (GMP) is the GMP level of Y-27632 dihydrochloride (HY-10583). GMP guidelines are used to produce Y-27632 dihydrochloride (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK (Rho-kinase) inhibitor with antiepileptic effect[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 10 mg; 50 mg; 100 mg. Product ID: HY-10583G. | |
| Y-27632 (dihydrochloride) (Standard) | Y-27632 (dihydrochloride) (Standard) is the analytical standard of Y-27632 (dihydrochloride). Y-27632 dihydrochloride is an orally active and ATP-competitive ROCK ( Rho-kinase ) inhibitor (ROCK-I K i =220 nM; ROCK-II K i =300 nM). Y-27632 dihydrochloride shows antiepileptic effects [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 129830-38-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10583R. | |
| Y-33075 | Y-33075 is a selective ROCK inhibitor derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Y-39983 free base. CAS No. 199433-58-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-10067. | |
| Yaddle1 | Yaddle1 is an agonist of the mechano-activated ion channel (Piezo1) with a half-maximal effective concentration (MEC50) of 0.40 ?M. Yaddle1 can significantly trigger Ca2+ inflow in T cells and induce T cell activation response. Yaddle1 can be used in the study of vaccine adjuvants[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-162501. | |
| Yamogenin | Yamogenin (Neodiosgenin) is a diastereomer of diosgenin. Yamogenin (Neodiosgenin) antagonizes the activation of the liver X receptor (LXR) in luciferase ligand assay. Yamogenin (Neodiosgenin) inhibits triacylglyceride (TG) accumulation through the suppression of gene expression of fatty acid synthesis in HepG2 hepatocytes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Neodiosgenin. CAS No. 512-06-1. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2078. | |
| Yangonin | Yangonin exhibits affinity for the human recombinant cannabinoid CB1 receptor with an IC 50 and a K i of 1.79 μM and 0.72 μM, respectively. Uses: Scientific research. Group: Natural products. CAS No. 500-62-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-N0919. | |
| YAP/TAZ inhibitor-1 | YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor extracted from patent WO2017058716A1, Compound 1, has an IC50 of <0.100 ?? in firefly luciferase assay[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2093565-23-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111429. | |
| YC-001 | YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1]. Uses: Scientific research. Group: Natural products. CAS No. 748778-73-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124717. | |
| YCT529 | YCT529 is a potent, selective and orally active RAR-α inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2863670-67-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153122A. | |
| YD23 | YD23 is a SMARCA2 PROTAC. YD23 induces degradation of SMARCA2, which is synthetic lethal to SMARCA4. Moreover, YD23 decreases chromatin accessibility at enhancers of a number of genes including cell cycle and cell growth regulatory genes. YD23 reduces chromatin accessibility only in SMARCA4 deficient cells mechanistically[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2951015-29-3. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153361. | |
| YE6144 | YE6144 is a prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-150095. | |
| Yeast extract | Yeast extract is a concentrate of the soluble part of yeast, especially Saccharomyces cerevisiae. The main nutritional components of yeast extract include partly hydrolyzed protein with 35-40% of free amino acid, and it also contain B vitamins and some trace elements. Yeast extract can be used as nutrients for bacterial culture media [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 8013-1-2. Pack Sizes: 50 g; 100 g. Product ID: HY-153126. | |
| YF-2 | YF-2 is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1311423-89-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16531. | |
| YF-2 hydrochloride | YF-2 hydrochloride is a highly selective, blood-brain-barrier permeable histone acetyltransferase activator, acetylates H3 in the hippocampus, with EC 50 s of 2.75 μM, 29.04 μM and 49.31 μM for CBP, PCAF, and GCN5, respectively, shows no effect on HDAC. Anti-cancer and anti-Alzheimer's disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1312005-62-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-16531A. | |
| YG1702 | YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 724737-08-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156443. | |
| Yhhu-3792 | Yhhu-3792 enhances the self-renewal capability of neural stem cells (NSCs). Yhhu-3792 activates Notch signaling pathway and promotes the expression of Hes3 and Hes5. Yhhu-3792 expands the NSCs pool and promotes endogenous neurogenesis in the hippocampal dentate gyrus (DG) in mouse. Yhhu-3792 increases the spatial and episodic memory abilities of mice. Yhhu-3792 has the potential for the research of impairment of learning and memory associated DG dysfunction[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2097826-24-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120782. | |
| YIGSR | YIGSR is a peptide that can inhibit the tumour growth and metastasis of leukaemic cells [1]. YIGSR blocks the cellular binding to laminin I via a 67-kDa laminin-binding protein, and inhibits shear-induced increase in eNOS expression of laminin cells [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Laminin Fragment 929-933. CAS No. 110590-64-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P0132. | |
| YIL781 | YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875258-85-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-13964. | |
| YIL781 hydrochloride | YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC 50 values of 7.90 and 8.27, respectively [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1640226-17-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13964A. | |
| YK11 | YK11 is a partial agonist of androgen receptor , with osteogenic activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1370003-76-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107480. | |
| YK-2168 | YK-2168 is a differentiated selective inhibitor of CDK9 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2571068-74-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-162919. | |
| YK-4-279 | YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1037184-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14507. | |
| YKL-05-099 | YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1936529-65-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-101147. | |
| YKL-06-061 | YKL-06-061 is a potent, selective, second-generation salt-inducible kinase (SIK) inhibitor with IC50 values of 6.56 nM/1.77 nM/20.5 nM for SIK1/2/3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172617-15-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-120056. | |
| YKL-06-062 | YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172617-16-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-129141. | |
| YKL-5-124 | YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1957203-01-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-101257. | |
| YL-365 | YL-365 is a angonist of GPR34. YL-365 is used for pain and cancer research[1]. Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-156815. | |
| YL-5092 | YL-5092 is an inhibitor for YT521-B homology (YTH) domain-containing protein 1 (YTHDC1). YL-5092 inhibits acute myeloid leukemia cell with IC50 of 0.28-2.87 ?M. YL-5092 exhibits antitumor efficacy in MOLM-13 or U937 xenograft mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3056857-07-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164607. | |
| YM-201636 | YM-201636 is a potent and selective PIKfyve inhibitor with an IC50 of 33 nM. YM-201636 also inhibits p110? with an IC50 of 3.3 ?M. YM-201636 inhibits retroviral replication. Uses: Scientific research. Group: Signaling pathways. CAS No. 371942-69-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13228. | |
| YM-298198 hydrochloride | YM-298198 hydrochloride is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216398-09-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103568. | |
| YM-341619 | YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation[1]. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma[2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS1617612. CAS No. 643082-52-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134771. | |
| YM-53601 | YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo[1]. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent[2]. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 182959-33-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100313A. | |
| YM-58483 | YM-58483 (BTP2) is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals. YM-584832 is a blocker of store-operated Ca2+ entry (SOCE)[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BTP2. CAS No. 223499-30-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100831. | |
| YM-90709 | YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 163769-88-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19969. | |
| YM976 | YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 191219-80-4. Pack Sizes: 5 mg; 10 mg. Product ID: HY-108617. | |
| YO-01027 | YO-01027 (Dibenzazepine;DBZ) is a potent ?-secretase inhibitor with IC50 values of 2.92 and 2.64 nM for Notch and APPL cleavage, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dibenzazepine; DBZ. CAS No. 209984-56-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13526. | |
| Yoda 1 | Yoda 1 is a potent and selective Piezo1 agonist. Yoda 1 activates purified Piezo1 channels. Yoda 1 potently inhibits macropinocytosis induced by epidermal growth factor (EGF). Yoda 1 enhances Ca 2+ influx followed by activation of the calcium-activated potassium channel KCa3.1 and inhibition of Rac1 activation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 448947-81-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18723. | |
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