MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| VU0486321 | VU0486321 is a compound in a class of mGlu1 positive allosteric modulators (PAMs). VU0486321 maintains acceptable mGlu1 PAM potency, DMPK profile, CNS permeability, and mGluR selectivity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1816301-67-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-118179. |  |
| VU0486846 | VU0486846 is an orally active and selective muscarinic acetylcholine receptor M1 positive allosteric modulator (PAM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1788055-11-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-121806. | |
| VU0529331 | VU0529331 is a modestly selective non-GIRK1-containing G protein-gated, inwardly-rectifying, potassium channel (non-GIRK1/X) activator, with EC50s of 5.1 μM and 5.2 μM for GIRK2 and GIRK1/2 in HEK293 cells, respectively, also effective on GIRK4 homomeric channel[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1286725-49-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112705. | |
| VU0650786 | VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1809085-30-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-108710. | |
| VU-29 | VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor ( EC 50 =9 nM and K i =244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC 50 : rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890764-36-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107508. | |
| VU590 | VU590 is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC 50 of 290 nM. VU590 also inhibits Kir7.1 , with an IC 50 of 8 μM. VU590 is not a good probe of ROMK function in the kidney [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 313505-85-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108595. | |
| VU6005649 | VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 ?M and 2.6 ?M for mGlu7 receptor and mGlu8 receptor, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 2137047-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107982. | |
| VU6036720 | VU6036720 is a potent and specific in vitro inhibitor of Kir4.1/5.1. VU6036720 can inhibit Kir4.1/5.1 channels with an IC 50 value of 0.24 μM. VU6036720 can be used for the research of brain and kidney [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026597-12-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-148304. | |
| Vudalimab | Vudalimab is a potent dual PD-1 and CTLA-4 inhibitor as a fully humanized bispecific monoclonal antibody. Vudalimab targets immune checkpoint receptors PD-1 and CTLA-4 and promotes tumor-selective T-cell activation [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2329669-72-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99166. | |
| VUF10166 | VUF10166 is a potent and high-affinity 5-HT 3 receptor antagonist, with K i values of 0.04 nM (5-HT 3 A) and 22 nM (5-HT 3 AB). VUF10166 inhibits 5-HT-induced responses at 5-HT 3 A and 5-HT 3 AB receptors at nanomolar concentrations. At 5-HT 3 receptor , VUF10166 at higher concentrations also acts as a partial agonist, with an EC 50 of 5.2 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 155584-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100552. | |
| VUF11207 fumarate | VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1785665-61-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110318. | |
| VUF 8430 dihydrobromide | VUF 8430 (dihydrobromide) is a potent and selective histamine H4 receptor agonist with a K i of 31.6 nM and an EC 50 of 50 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100130-32-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-107555. | |
| Vunakizumab | Vunakizumab (Anti-Human IL17A Recombinant Antibody) is a recombinant human IgGκ monoclonal antibody that targets IL-17A and inhibits its interaction with the IL-17 receptor. Vunakizumab can be used to study autoimmune diseases such as psoriatic arthritis, ankylosing spondylitis, multiple sclerosis and inflammatory arthritis [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL17A Recombinant Antibody. CAS No. 1792181-33-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99335. | |
| VUT-MK142 | VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1313491-22-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122610. | |
| VVD-130037 | VVD-130037 (BAY-3605349) is an orally active covalent activator of KEAP 1 (Kelch-like ECH-associated protein 1) with anti-tumor activity. VVD-130037 degrades NRF2 (nuclear factor-erythroid 2 p45-related factor 2), resulting in significant inhibition of tumor growth in advanced solid tumors[1][2][3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY-3605349. CAS No. 3034880-93-5. Pack Sizes: 10 mM * 1 mL; 5 mg. Product ID: HY-159641. | |
| VVD-214 | VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC50 of 0.1316 μM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RO7589831; VVD-133214. CAS No. 3026500-20-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158116. | |
| VX-11e | VX-11e is a potent, selective, and orally bioavailable inhibitor of ERK with Ki < 2 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 896720-20-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14178. | |
| VX-702 | VX-702 is a highly selective inhibitor of p38? MAPK, 14-fold higher potency against the p38? versus p38?[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 745833-23-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10401. | |
| VX-984 | VX-984 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium[1][2][3]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: M9831. CAS No. 1476074-39-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19939S. | |
| VY-3-135 | VY-3-135 is a potent, orally active, and stable ACSS2 inhibitor with an IC50 value of 44 nM. VY-3-135 is specific to ACSS2 among the AcCoA synthetase family of enzymes. VY-3-135 does not inhibit ACSS1 or ACSS3 enzymatic activity. VY-3-135 can be used for the research of breast cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1824637-41-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145953. | |
| VZ185 | VZ185 is a potent, fast, and selective von Hippel-Lindau based dual degrader probe of BRD9 and BRD7 with DC50s of 4.5 and 1.8 nM, respectively. VZ185 is cytotoxic in EOL-1 and A-402 cells, with EC50s of 3 nM and 40 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2306193-61-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114322. | |
| W-13 hydrochloride | W-13 hydrochloride is a calmodulin antagonist. W-13 hydrochloride can inhibit Tamoxifen (HY-13757A)-resistant human breast cancer cell growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 88519-57-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100910. | |
| W146 | W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 909725-61-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101395. | |
| W-5 hydrochloride | W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC 50 value of 240 μM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61714-25-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100911. | |
| W-7 hydrochloride | W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca 2+ -calmodulin -dependent phosphodiesterase and myosin light chain kinase with IC 50 values of 28 μM and 51 μM, respectively [1] [2]. W-7 hydrochloride induces apoptosis and has antitumor activity [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 61714-27-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100912. | |
| W-84 dibromide | W-84 (dibromide) is a potent allosteric modulator of M2-cholinoceptors , which retards [ 3 H]N-methylscopolamine dissociation. W-84 dibromide can stabilize cholinergic antagonist-receptor complexes. W-84 (dibromide) is a non-competitive muscarinic acetylcholine receptors antagonist with allosteric effects. W-84 (dibromide) protects over additively against an organophosphate-intoxication when applied in combination with atropine [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HDMPPA. CAS No. 21093-51-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100979. | |
| Water-17O | Water- 17 O is the 17 O labeled Water [1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 13768-40-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108872S1. | |
| Water-18O | Water- 18 O is the 18 O-labeled Water [1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 14314-42-2. Pack Sizes: 100 mg; 250 mg. Product ID: HY-108872S. | |
| Watermelon ketone | Watermelon ketone is fragrance chemical compound with special odorant which has been widely used in the fragrance industry, extracted from patent CN 103058984 A. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Methyl-2H-1,5-benzodioxepin-3(4H)-one. CAS No. 28940-11-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W016622. | |
| WAY-100135 dihydrochloride | WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT 1A receptor, with an IC 50 of 34 nM at the rat hippocampal 5-HT 1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 149055-79-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117575A. | |
| WAY-100635 | WAY-100635 is a potent and selective 5-HT 1A Receptor antagonist with a pIC 50 of 8.87, an apparent pA 2 of 9.71. WAY-100635 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC 50 value of 0.91 nM and K i value of 0.39 nM. WAY-100635 has pIC 50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 is also a potent dopamine D 4 receptor agonist [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162760-96-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10349. | |
| WAY-100635 maleate | WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC 50 value of 0.91 nM and K i value of 0.39 nM. WAY-100635 maleate has pIC 50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D 4 receptor agonist [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092679-51-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10349A. | |
| WAY-181187 | WAY-181187 (SAX-187) is a potent and selective full 5-HT6 receptor agonist with a K i of 2.2 nM and an EC 50 of 6.6 nM [1]. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SAX-187. CAS No. 554403-49-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-14340. | |
| WAY-200070 | WAY-200070 is a selective estrogen receptor β ( ERβ ) agonist with an IC 50 of 2.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 440122-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101271. | |
| WAY208466 dihydrochloride | WAY 208466 dihydrochloride is a potent and selective 5-HT 6 receptor agonist ( EC 50 =7.3 nM for the human 5-HT 6 receptor). WAY-208466 dihydrochloride elevates cortical GABA levels in rat frontal cortex [1]. WAY 208466 dihydrochloride exhibits antidepressant and anxiolytic-like effects [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1207064-61-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103133. | |
| WAY-262611 | WAY-262611 is a Wnt / β-Catenin agonist that increases bone formation rate with an EC 50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1123231-07-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-11035. | |
| WAY-621089 | WAY-621089 is an active molecule for the study of amyloid diseases and synucleinopathies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 303790-92-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-47595. | |
| WBC100 | WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. WBC100 is a c-Myc degrader and targets ubiquitin E3 ligase CHIP mediated 26S proteasome pathway. WBC100 is used for c-Myc overexpressing tumors research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 14-D-Valine-TPL. CAS No. 2095780-08-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145898. | |
| WD6305 TFA | WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity[1].(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803)). Uses: Scientific research. Group: Signaling pathways. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160415A. | |
| WDR5-IN-4 | WDR5-IN-4 (Compound C6) is a WIN site inhibitor of chromatin-associated WD repeat domain 5 protein (WDR5), Kd The value is 0.1 nM. WDR5-IN-4 is able to displace WDR5 from chromatin and reduce the expression of related genes, causing translation inhibition and nucleolar stress. Has anti-cancer effects [1][1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2407457-36-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-111753. | |
| WDR5-IN-5 | WDR5-IN-5 is an orally active and selective inhibitor of WIN site of WD repeat domain 5 (WDR5). WDR5-IN-5 exhibits anti-proliferative activity towards cancer cells and good pharmacokinetics profile in mice. WDR5-IN-5 shows high affinity to WDR5 and the binding affinity Ki value <0.02 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2417012-26-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-150654. | |
| WDR5-IN-6 | WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 (HY-16993), a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 326901-92-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154949. | |
| Wedelolactone | Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase ( 5-Lox ) with an IC 50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 524-12-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0551. | |
| WEHI-345 | WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC 50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1354825-58-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18937. | |
| WEHI-345 analog | WEHI-345 analog is the analog of WEHI-345. WEHI-345 is a potent and selective RIPK2 kinase inhibitor with an IC 50 of 0.13 μM, which delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1354825-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100112. | |
| WEHI-539 hydrochloride | WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL with an IC50 of 1.1 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070018-33-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15607A. | |
| Werner syndrome RecQ helicase-IN-4 | Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC 50 value of 0.06 μM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2869954-53-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148741. | |
| WH-15 | WH-15 is a fluorogenic PLC reporter with K m value of 49; 30, 86.1 μM for PLC-γ1, PLC-δ1, PLC-β2, respectively. WH-15 can be cleaved in a cascade reaction to generate fluorescent 6-aminoquinoline. WH-15 can be used to respond to imaging PLC activity in live cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1264748-47-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-135799. | |
| WH-4-023 | WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively; little inhibition on p38? and KDR. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dual LCK/SRC inhibitor. CAS No. 837422-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12299. | |
| WHI-P180 | WHI-P180 (Janex 3) is a multi-kinase inhibitor; inhibits RET , KDR and EGFR with IC 50 s of 5 nM, 66 nM and 4 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Janex 3. CAS No. 211555-08-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15769. | |
| White mineral oil | White mineral oil is the highly refined mineral oil, and is composed of saturated aliphatic and alicyclic nonpolar hydrocarbons. White mineral oil is biologically and chemically stable, and doesnt support pathogenic bacterial growth. White mineral oil can resist moisture, extend, soften, smoothen, and lubricate [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Paraffin oil. CAS No. 8042-47-5. Pack Sizes: 5 mL. Product ID: HY-139411. | |
| WIKI4 | WIKI4 is a potent tankyrase inhibitor with an IC50 of 26 nM for TNKS2. WIKI4 potently inhibits Wnt/?-catenin signaling and that its half-maximal response dose is 75 nM. WIKI4 mediates its effects on Wnt/?-catenin signaling by inhibiting the enzymatic activity of TNKS2[1][2]. WIKI4 is cytotoxic to SCLC cells with an IC50 value of 0.02 ?M[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 838818-26-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16910. | |
| Win 18446 | Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC 50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1477-57-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-W011094. | |
| Wiskostatin | Wiskostatin is a potent and selective inhibitor of neuronal Wiskott-Aldrich syndrome protein (N-WASP)-mediated actin polymerization by stabilization of the closed, autoinhibited conformation, thereby preventing Arp2/3 complex activation. Wiskostatin is also a dynamin inhibitor with an IC50 value of 20.7 ?M and a potent inhibitor of clathrin-mediated endocytosis with an IC50 value of 6.9 ?M. Wiskostatin causes a rapid, profound, and irreversible decrease in cellular ATP levels. Wiskostatin also induces disassembly of podosomes in a murine monocyte cell line[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 253449-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12534. | |
| Withaferin A | Withaferin A is a steroidal lactone isolated from Withania somnifera , inhibits NF-kB activation and targets vimentin , with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Uses: Scientific research. Group: Natural products. CAS No. 5119-48-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N2065. | |
| Withanolide A | Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 32911-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7028. | |
| Withanone | Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA) -induced excitotoxicity in Neuron-like cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 27570-38-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129692. | |
| WM-1119 | WM-1119 is a highly potent and selective KAT6A inhibitor, with an IC50 of 0.25 ?M for KAT6A in lymphoma cells, the binding KD values of WM-1119 with KAT6A, KAT5 and KAT7 are 2 nM, 2.2 ?M, 0.5 ?M , respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055397-28-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102058. | |
| WM-3835 | WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2229025-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134901. | |
| WM-662 | WM-662 is a WDR5-MYC interaction inhibitor, with an IC 50 of 18 μM. WM-662 has potential for the research of cancer, aging, and neurodegenerative disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1308257-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-154847. | |
| WM-8014 | WM-8014 is an inhibitor of MOZ, a member of histone acetyltransferases, with an IC50 of 55 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 2055397-18-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-102060. | |
| WNK1-IN-1 | WNK1-IN-1 is a selective inhibitor of WNK1 with an IC50 value of 1.6 ?M. WNK1-IN-1 inhibits OSR1 phosphorylation with an IC50 value of 4.3 ?M. WNK1-IN-1 can be used for the research of blood pressure regulation and cancer[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 324022-39-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-151545. | |
| WNK463 | WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK)-kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2012607-27-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100626. | |
| WNK-IN-11 | WNK-IN-11 is an allosteric With-No-Lysine (WNK) kinase inhibitor, with an IC50 of 4 nM for WNK1. Uses: Scientific research. Group: Signaling pathways. CAS No. 2123489-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112094. | |
| Wnt-C59 | Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC 50 of 74 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C59. CAS No. 1243243-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15659. | |
| WNTinib | WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenic Wnt signaling by inhibiting KIT/MAPK and downstream EZH2 activation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APS-8-100-2. CAS No. 2770091-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160765. | |
| Wnt pathway inhibitor 3 | Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC 50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663213-98-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153750. | |
| Wnt pathway inhibitor 4 | Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663214-57-1. Pack Sizes: 10 mg. Product ID: HY-153753. | |
| Wogonin | Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt , and exhibits anti-inflammatory and anti-tumor effects. Uses: Scientific research. Group: Natural products. CAS No. 632-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0400. | |
| Wogonoside | Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 51059-44-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0399. | |
Would you like to list your products on USA Chemical Suppliers?
Our database is helping our users find suppliers everyday.