MedChemExpress MCE - Products
MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use.
| Product | Description | |
|---|---|---|
| BI 2536 | BI 2536 is a dual PLK1 and BRD4 inhibitor with IC50s of 0.83 and 25 nM, respectively[1]. BI-2536 suppresses IFNB (encoding IFN-?) gene transcription[4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 755038-02-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-50698. |  |
| BI-2545 | BI-2545 is a potent autotaxin (ATX) inhibitor that significantly reduces LPA, with IC 50 s of 2.2 nM and 3.4 nM for human ATX and rat ATX, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2162961-71-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124772. | |
| BI-2852 | BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 ?M). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 2375482-51-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126247. | |
| BI-2865 | BI-2865 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2937327-93-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153724. | |
| BI-3406 | BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230836-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-125817. | |
| BI-3802 | BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 of ?3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2166387-65-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108705. | |
| BI-4394 | BI-4394 (MMP13-IN-3) is a potent, selective, and orally active MMP-13 inhibitor ( IC 50=1 nM [1] ) for the potential treatment of osteoarthritis [2]. BI-4394 is >1000 selective over other MMPs [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MMP13-IN-3. CAS No. 1222173-37-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124029. | |
| BI-4464 | BI-4464 is a highly selective, ATP competitive PTK2/FAK protein kinase inhibitor with an IC50 value of 17 nM. BI-4464 can be used as a PTK2 ligand for constructing proteolysis targeting chimeras (PROTAC). Uses: Scientific research. Group: Signaling pathways. CAS No. 1227948-02-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124625. | |
| BI-4916 | BI-4916 is a proagent of BI-4924. BI-4924 is a NADH/NAD+-competitive PHGDH inhibitor. BI-4916 inhibits cancer cell migration. BI-4916 can be used for cancer, inflammation and infection study[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2244451-48-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126253. | |
| BI-6015 | BI-6015 is a hepatocyte nuclear factor 4? (HNF4?) antagonist that can inhibit the expression of known HNF4? target genes. BI6015 represses insulin promoter activity through HNF4? antagonism. BI-6015 can be used for the research of cancer and diabetes[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93987-29-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108469. | |
| BI 639667 | BI 639667 (compound 19n), a third azaindazole series compound, is a CCR1 antagonist, with an IC 50 of 1.8 nM in Ca 2+ flux assay [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCR1 antagonist 8. CAS No. 1295298-26-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-120588. | |
| BI-7273 | BI-7273 is a selective, and cell-permeable BRD9 inhibitor, with an IC50 and a Kd of 19 and 0.75 nM; also shows high effect on BRD7, with an IC50 and a Kd of 117 nM and 0.3 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883429-21-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100351. | |
| BI-749327 | BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC50s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2361241-23-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111925. | |
| BI8622 | BI8622 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 3.1 ?M. BI8622 can decrease the protein expression levels of c-myc and glycolytic markers as well as immune modulatory markers after HUWE1 inhibition in triple-negative breast cancer (TNBC) cell lines. BI8622 significantly protects against cisplatin (HY-17394)-induced acute kidney injury (AKI). BI8622 significantly reduces the growth of multiple myeloma (MM) cell lines and induces cell cycle arrest. BI8622 can prevent HUWE1-dependent TTBK2 ubiquitination. BI8622 can be studied in research for various diseases including medulloblastoma, acute kidney injury, breast cancer and MM[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875036-74-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120929. | |
| BI8626 | BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 ?M[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1875036-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-120204. | |
| BI-9321 trihydrochloride | BI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 ?M in U2OS cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2387510-87-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114208A. | |
| BI-9564 | BI-9564 is a potent, selective and cell-permeable BRD9/BRD7 bromodomains inhibitor, with IC50s of 75 nM and 3.4 ?M and Kds of 14 nM and 239 nM, respectively. BI-9564 has an IC50 of > 100 ?M for BET family[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1883429-22-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100352. | |
| BI-9627 | BI-9627 is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor (IC50 = 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays). BI-9627 displays >30-fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI-9627 decreases autophagy in HTR-8/SVneo cells. BI-9627 can significantly reduce the pHi of human sperm and partially reverse the effect of DMA. BI-9627 prolongs Ca2+ recovery time in KO hiPSC-CMs. BI-9627 shows low DDI (agent-agent interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart model of ischemia-reperfusion injury[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1204329-34-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18071. | |
| BI 99179 | BI 99179 is a potent and selective type I fatty acid synthase ( FAS ) inhibitor with an IC 50 of 79 nM. BI 99179 is a tool compound suitable for the in vivo validation of FAS as a target for lipid metabolism related diseases. BI 99179 exhibits significant exposure (both peripheral and central) upon oral administration in rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1291779-76-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16100. | |
| BIA 10-2474 | BIA 10-2474 is an inhibitor of fatty acid amide hydrolase ( FAAH ) with IC 50 values of 50 to 70mg/kg in various rat brain regions. Uses: Scientific research. Group: Signaling pathways. CAS No. 1233855-46-3. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19740. | |
| Bialaphos sodium | Bialaphos (SF-1293) sodium, an antibiotic , is an effective herbicide is a metabolite of Streptomyces hygroscopicus [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SF-1293 sodium. CAS No. 71048-99-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-122494A. | |
| Biapenem | Biapenem (CLI 86815; L 627; LJC 10627) a parenteral carbapenem antibacterial agent with a broad spectrum. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CLI 86815; L 627; LJC 10627. CAS No. 120410-24-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13573. | |
| BIBP3226 TFA | BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with K i s of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1068148-47-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107726. | |
| BIBR 1532 | BIBR 1532 is a potent, selective and non-competitive telomerase inhibitor with IC 50 of 100 nM in a cell-free assay. Uses: Scientific research. Group: Signaling pathways. CAS No. 321674-73-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17353. | |
| BIBS 39 | BIBS 39 is a new nonpeptide angiotensin II (AII) receptor antagonist. Uses: Scientific research. Group: Signaling pathways. CAS No. 133085-33-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-19732. | |
| Bicalutamide | Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 90357-06-5. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-14249. | |
| Bicarbonate-13C sodium | Bicarbonate- 13 C (sodium) is the 13 C labeled Bicarbonate sodium[1]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 87081-58-1. Pack Sizes: 50 mg; 100 mg. Product ID: HY-W251598S. | |
| Bicine | Bicine is a buffer used in physiological research. Bicine is a derivative of the simple amino acid glycine that increases the sensitivity of guanosine enzyme histochemical detection [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 150-25-4. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-D0868. | |
| Bictegravir | Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC 50 of 7.5 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9883. CAS No. 1611493-60-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17605. | |
| Bictegravir sodium | Bictegravir sodium is a potent inhibitor of HIV-1 integrase , with an IC 50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GS-9883 sodium. CAS No. 1807988-02-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17605A. | |
| Bicuculline | Bicuculline ((+)-Bicuculline) is A competing neurotransmitter GABA A receptor antagonist ( IC 50 =2 μM). Bicuculline also blocks Ca 2+ activating potassium (SK) channels and subsequently blocks slow post-hyperpolarization (slow AHP). Bicuculline has anticonvulsant activity. Bicuculline can be used to induce seizures in mice [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: (+)-Bicuculline; d-Bicuculline. CAS No. 485-49-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-N0219. | |
| Bicuculline methiodide | Bicuculline methiodide is a potent GABA(A) receptors blocker. Bicuculline methiodide alters membrane properties and firing pattern. Bicuculline methiodide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca 2+ -activated K + channels. Bicuculline methiodide facilitates burst firing via blocking apamin-sensitive Ca 2+ -activated K + current [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Bicuculline methiodide; l-Bicuculline methiodide. CAS No. 40709-69-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103474. | |
| (-)-Bicuculline methobromide | (-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABA A receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca 2+ -activated K + channels in various types of neurons [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: l-Bicuculline methobromide. CAS No. 73604-30-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-100783. | |
| Bicuculline methochloride | Bicuculline ((+)-Bicuculline; d-Bicuculline) methochloride is a selective GABAA receptor antagonist with an IC 50 value of 3 μM. Bicuculline methochloride induces clonic tonic convulsions in mammals and can also be used to block Ca 2+ activated potassium channels. Bicuculline methochloride can be used in studies of epilepsy and other related psychiatric disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (-)-Bicuculline methochloride; l-Bicuculline methochloride. CAS No. 38641-83-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137790. | |
| Bicyclol | Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti- apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1 , GSH/GST and Bcl-2 , increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SY801. CAS No. 118159-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-B0766. | |
| Bicyclomycin benzoate | Bicyclomycin benzoate is an antibiotic exhibiting activity against a broad spectrum of Gram-negative bacteria and against the Gram-positive bacterium. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FR2054. CAS No. 37134-40-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101128. | |
| BI-D1870 | BI-D1870 is an ATP-competitive, cell permeable and brain penetrated inhibitor of RSK isoforms, with IC50s of 31 nM/24 nM/18 nM/15 nM for RSK1/RSK2/RSK3/RSK4, respectively[1][2][3][4][5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 501437-28-1. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10510. | |
| Bidisomide | Bidisomide (SC40230) is a class I antiarrhythmic agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SC40230. CAS No. 116078-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-U00232. | |
| Bifemelane hydrochloride | Bifemelane hydrochloride (MCI-2016) is a potent, selective and competitive inhibitor of monoamine oxidase A (MAO-A) , with a K i of 4.20 μM. Bifemelane hydrochloride also inhibits MAO-B noncompetitively with a K i of 46.0 μM. Bifemelane hydrochloride has a potent antidepressant activity and can be used for the research of cognitive and emotional disturbances related to cerebrovascular disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MCI-2016. CAS No. 62232-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B1558A. | |
| Bifenazate | Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm [1]. Bifenazate is a positive allosteric modulator of GABA receptor [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 149877-41-8. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-119687. | |
| Bifendate | Bifendate (DDB), extracted from Schisandrae chinensis , is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins ( CYPs ) and reverse P-gp -mediated multi-drug resistance (MDR) [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DDB. CAS No. 73536-69-3. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-W018791. | |
| Bifenthrin | Bifenthrin is a synthetic pyrethroid insecticide. Bifenthrin prolongs the opening time of Nav1.8 sodium channels , leading to membrane depolarization and conductance block in the insect nervous system, thereby disrupting neural function. Bifenthrin was effective in inhibiting A. gambiae ( LD 50 =0.15 ng/mg) and C. quinquefasciatus ( LD 50 =0.16 ng/mg). Bifenthrin has good lethality against susceptible and resistant mosquitoes and is very effective in inhibiting blood sucking and can be developed as a mosquito-removal netting material [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 82657-04-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0824. | |
| Bifeprunox mesylate | Bifeprunox mesylate is a potent dopamine D2 -like and 5-HT1A receptor partial agonist with pK i s of 7.19 and 8.83 for cortex 5-HT1A and striatum D2, and a pEC 50 of 6.37 for hippocampus 5-HT1A, respectively. Bifeprunox mesylate is an antipsychotic for the research of schizophrenia [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 350992-13-1. Pack Sizes: 5 mg. Product ID: HY-14547A. | |
| Bifonazole | Bifonazole (Bay H-4502) is an imidazole antifungal agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Bay H-4502. CAS No. 60628-96-8. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-B0301. | |
| Bigelovin | Bigelovin, a sesquiterpene lactone isolated from Inula hupehensis, is a selective retinoid X receptor ? agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation[1]. Uses: Scientific research. Group: Natural products. CAS No. 3668-14-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-116506. | |
| Biguanide | Biguanide is an orally active antihyperglycemic agent. Biguanide inhibits mitochondrial ATP production, activates the LKB1-AMPK signaling pathway, and damages the energy homeostasis. Biguanide exhibits potential in ameliorating the type 2 diabetes and the insulin-associated cancers [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 56-03-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121006. | |
| BIIB021 | BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a K i and an EC 50 of 1.7 nM and 38 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CNF2024. CAS No. 848695-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10212. | |
| BIIB091 | BIIB091 is a potent, selective, orally active and reversible BTK inhibitor, with an IC 50 of <0.5 nM. BIIB091 binds the BTK protein to sequester TYR-551 into an inactive conformation with excellent affinity. BIIB091 can be used for the research of multiple sclerosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2247614-80-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139984. | |
| BIIE-0246 | BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC 50 value of 15 nM for rat [ 125 I]PYY 3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AR-H 053591. CAS No. 246146-55-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101986. | |
| BIIL-260 hydrochloride | BIIL-260 hydrochloride is a potent and long-acting orally active leukotriene B(4) receptor LTB 4 antagonist, with anti-inflammatory activity. BIIL-260 hydrochloride interacts with the LTB 4 receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB 4 receptor on isolated human neutrophil cell membranes with K i values of 1.7 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192581-24-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-114641A. | |
| Bikaverin | Bikaverin (Lycopersin) is a reddish pigment produced by different fungal species. Bikaverin shows antibiotic properties against certain protozoa and fungi [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Lycopersin. CAS No. 33390-21-5. Pack Sizes: 500 μg; 1 mg. Product ID: HY-121004. | |
| Bilastine | Bilastine is an oral histamine H1-receptor antagonist. Bilastine can be used for allergic rhinitis and urticaria studies, and it also improves diabetic nephropathy in mice, showing safety for the central nervous system [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 202189-78-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-14447. | |
| Bile extract | Bile extract is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: Ox bile extract. CAS No. 8008-63-7. Pack Sizes: 5 g. Product ID: HY-N8332. | |
| Biliatresone | Biliatresone is a natural toxin isolated from Dysphania glomulifera and D. littoralis. Biliatresone, a 1,2-diaryl-2-propenone class of isoflavonoid, produces extrahepatic biliary atresia in a zebrafish model [1]. Uses: Scientific research. Group: Natural products. CAS No. 1801433-90-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119412. | |
| Bilirubin | Bilirubin is a yellow breakdown product of heme catabolism [1]. Bilirubin exhibits antioxidant and antimutagenic effects [2]. Uses: Scientific research. Group: Natural products. CAS No. 635-65-4. Pack Sizes: 50 mg. Product ID: HY-N0323. | |
| Bilirubin oxidase | Bilirubin oxidase (BOD) is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BOD. CAS No. 80619-01-8. Pack Sizes: 250 U; 500 U; 1000 U. Product ID: HY-P2888. | |
| Biliverdin | Biliverdin, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant [1]. Uses: Scientific research. Group: Natural products. CAS No. 114-25-0. Pack Sizes: 1 mg. Product ID: HY-135005A. | |
| Biliverdin hydrochloride | Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant [1]. Uses: Scientific research. Group: Natural products. CAS No. 856699-18-8. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-135005. | |
| Bilobalide | Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba , inhibits the NMDA-induced efflux of choline with an IC 50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (-)-Bilobalide. CAS No. 33570-04-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0076. | |
| Bimagrumab | Bimagrumab (Anti-ACVR2B Reference Antibody) is a human monoclonal antibody that blocks activin type II receptor (ActRII) , with K D s of 1.7 pM and 434 pM for human ActRIIB and ActRIIA , respectively. Bimagrumab can be used for the research of pathological muscle loss and weakness [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-ACVR2B Reference Antibody; BYM338. CAS No. 1356922-05-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99355. | |
| Bimatoprost | Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AGN 192024. CAS No. 155206-00-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-B0191. | |
| Bim BH3 | Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.). Uses: Scientific research. Group: Peptides. CAS No. 505070-06-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-P1527. | |
| Bi-Mc-VC-PAB-MMAE | Bi-Mc-VC-PAB-MMAE consists ADCs linker (Bi-Mc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE, HY-15162). Bi-Mc-VC-PAB-MMAE is a drug-linker conjugate for ADC. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620837-70-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141833. | |
| Bimekizumab | Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) is a humanised monoclonal antibody, can selectively neutralises IL-17A and IL-17F. Both of them are pro-osteogenic with respect to human periosteum-derived cell (hPDC) differentiation. Thus Bimekizumab blocks the inflammation-driven osteogenic differentiation [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: Anti-Human IL17A/IL-17F Recombinant Antibody. CAS No. 1418205-77-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99280. | |
| Bim-IN-1 | Bim-IN-1 is a potent Bim expression inhibitor. Bim-IN-1 reduces Bim expression levels and has little inhibitory effect upon protein kinase A activity and minimal toxicity[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2909483-36-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115930. | |
| Bimiralisib | Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for PI3K?, PI3K?, PI3K?, PI3K? and mTOR, respectively. Bimiralisib is an mTORC1 and mTORC2 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PQR309. CAS No. 1225037-39-7. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12868. | |
| Bimoclomol | Bimoclomol is a heat shock protein (HSP) coinducer, used for treatment of cardiovascular diseases. Uses: Scientific research. Group: Signaling pathways. CAS No. 130493-03-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00398. | |
| Bimosiamose | Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 ?M, 20 ?M, and 86 ?M for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose has anti-inflammatory effects[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TBC-1269. CAS No. 187269-40-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106139. | |
| BIMU 8 | BIMU 8 is a potent and selective 5-HT4 agonist with EC 50 s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor , T3.36A , and W6.48A mutant 5-HT4 receptors [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 134296-40-5. Pack Sizes: 1 mg. Product ID: HY-110094. | |
| Bindarit | Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1?/CCL3, MIP-1?/CCL4, MIP-3/CCL23. Bindarit also has anti-inflammatory activity[1]. Uses: Scientific research. Group: Natural products. Alternative Names: AF2838. CAS No. 130641-38-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0498. | |
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